This is a 4-week pilot, multicenter, randomized, double-blinded placebo controlled trial of hydroxocobalamin and butyrate in ulcerative colitis (UC) that will occur in two phases. The main objectives of this study are to determine the capacity of hydroxocobalamin and butyrate to reduce calprotectin in those with inflammatory disease in UC to determine the safety and preferential dose of hydroxocobalamin with butyrate in UC.

开始日期2024-01-01

申办/合作机构

The Brigham & Women's Hospital, Inc.

NCT05536596 / Not yet recruiting临床2/3期IIT

Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy: a Randomized, Double-blind Trial

The bilateral sagittal split osteotomy (BSSO) of the mandible is one of the most used surgical techniques to achieve a harmonious jaw relation in the context of orthognathic surgery. Nevertheless, one of its main complications is neurosensory damage to the inferior alveolar nerve, which can cause severe impact in the quality of life on patients who suffer from it permanently. The purpose of this randomized clinical trial is to provide rigorous scientific evidence of the pharmacological effect of 1) Melatonin, 2) combination uridine triphosphate (UTP), cytidine monophosphate (CMP), and hydroxycobalamin (UTP/CMP/hydroxycobalamin) and 3) hydroxycobalamin regarding neurosensory disturbances incidence and persistence after BSSO.

开始日期2022-09-30

申办/合作机构

Universitat Internacional de Catalunya

[+1]

IRCT20211207053311N1 / Recruiting临床3期IIT

Evaluation of response rate to hydroxycobalamin treatment in patients with methylmalonic acidemia

开始日期2022-02-04

申办/合作机构

Mashhad University of Medical Sciences

100 项与羟钴胺相关的临床结果

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100 项与羟钴胺相关的转化医学

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100 项与羟钴胺相关的专利（医药）

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3,663

项与羟钴胺相关的文献（医药）

2025-02-01·Archivos Argentinos de Pediatria

Acute cyanide intoxication due to apricot seed ingestion

Article

作者: Güngör, Emre ; Orhan, Özhan ; Talay, Mehmet N

Introduction: Cyanide poisoning, whether it be accidental or intentional, remains a significant danger to adults and children, especially in societies where agriculture is a primary source of income. We examined the clinical follow-up, complications, and results of cyanide poisoning cases that occurred after eating the pits and seeds of plants containing cyanide glycosides, such as apricot kernels and almonds. Methods: Between 01/01/2017 and 01/08/2022, 14 children aged 1-18 years who were followed up with a prediagnosis of cyanide poisoning in our Paediatric Intensive Care Unit (PICU) were retrospectively analysed. Results: Eight of the patients followed with a preliminary diagnosis of cyanide poisoning were female and six were male. The most common admission month was July (42.8%) coinciding with the agricultural season. The most common symptoms at presentation were weakness and fatigue (n = 7). In the PICU, 4 patients presented lip cyanosis; 3, altered level of consciousness. Vomiting, seizure, headache, dizziness and palpitatons were less frequent. Four patients were treated with hydroxocobalamin (Cyanokit®) as an antidote due to acidosis in their blood gases. All patients treated for cyanide poisoning were discharged. Conclusions: Cyanide poisoning should be considered in paediatric patients with suspicious findings, sudden loss of consciousness, increased anion gap acidosis and lactic acidosis. The history of eating the seeds of plants such as apricot and almonds should be investigated.

2025-01-01·FOOD CHEMISTRY

Impact of fermentation by Saccharomyces Cerevisiae on the macronutrient and in vitro digestion characteristics of Chinese noodles

Article

作者: Liu, Shuhang ; Yao, Ke ; Song, Xiaoyan ; Qiu, Shoukuan ; Sun, Jingwei

This study examined the impact of live bread yeast (Saccharomyces cerevisiae) on the nutritional characteristics of Asian dried noodles. Micronutrient analysis of fermented noodles revealed a 6.9% increase in the overall amino acid content, a 37.1% increase in the vitamin B content and a 63.0% decrease in the phytic acid level. Molecular weight analysis of starch and protein contents revealed moderate decrease in the fermented noodles. The in vitro digestion of fermented noodles showed a slightly faster initial acidification, four-fold decrease in the initial shear viscosity (from 8.85 to 1.94 Pa·s). The initial large food particle count (>2 mm diameter) was 19.5% lower in the fermented noodles. The fermented noodles contained slightly higher free sugar content (73.5 mg g^-1 noodle) during the gastric digestion phase. The overall nutrition and digestion results indicate nutritional improvement and digestion-easing attributes in the fermented noodles.

2024-12-01·FOOD CHEMISTRY

Enhancement of vitamin B stability with the protection of whey protein and their interaction mechanisms

Article

作者: Fan, Yan ; Hou, Hu ; Guo, Yueting ; Zhao, Xue ; Dong, Jingning ; Zhang, Zhaohui ; Yang, Tingting ; Wang, Feifei ; Li, Shiqi

Vitamin B is easily degraded by light and heat during storage, which results in nutritional loss of food. Whey protein is expected to protect vitamin B by forming complexes through secondary bonds. The properties of the complexes and protective effects of whey protein on vitamins B₁, B₂, B₃ and B₆ were characterized. The percentage losses of vitamin B were decreased by more than 60% with the protection of whey protein. FTIR, fluorescence spectroscopy, thermodynamic analysis and molecular docking were used to investigate the binding interaction between vitamin B and whey protein. Vitamin B quenched the intrinsic fluorescence of whey protein, mainly with a static nature (Kq > 2.0 × 10¹⁰ L/(mol·s)). The interactions between whey protein and vitamin B were mostly mediated by hydrogen bonds and van der Waals forces, as demonstrated by the thermodynamic parameters and molecular docking.

项与羟钴胺相关的新闻（医药）

2024-03-28

·Science Daily

Eggs may not be bad for your heart after all

Whether you like your eggs sunny-side up, hard boiled or scrambled, many hesitate to eat them amid concerns that eggs may raise cholesterol levels and be bad for heart health. However, results from a prospective, controlled trial show that over a four-month period cholesterol levels were similar among people who ate fortified eggs most days of the week compared with those who didn't eat eggs. Whether you like your eggs sunny-side up, hard boiled or scrambled, many hesitate to eat them amid concerns that eggs may raise cholesterol levels and be bad for heart health. However, results from a prospective, controlled trial presented at the American College of Cardiology's Annual Scientific Session show that over a four-month period cholesterol levels were similar among people who ate fortified eggs most days of the week compared with those who didn't eat eggs. A total of 140 patients with or at high risk for cardiovascular disease were enrolled in the PROSPERITY trial, which aimed to assess the effects of eating 12 or more fortified eggs a week versus a non-egg diet (consuming less than two eggs a week) on HDL- and LDL-cholesterol, as well as other key markers of cardiovascular health over a four-month study period. "We know that cardiovascular disease is, to some extent, mediated through risk factors like high blood pressure, high cholesterol and increased BMI and diabetes. Dietary patterns and habits can have a notable influence on these and there's been a lot of conflicting information about whether or not eggs are safe to eat, especially for people who have or are at risk for heart disease," said Nina Nouhravesh, MD, a research fellow at the Duke Clinical Research Institute in Durham, North Carolina, and the study's lead author. "This is a small study, but it gives us reassurance that eating fortified eggs is OK with regard to lipid effects over four months, even among a more high-risk population." Eggs are a common and relatively inexpensive source of protein and dietary cholesterol. Nouhravesh and her team wanted to look specifically at fortified eggs as they contain less saturated fat and additional vitamins and minerals, such as iodine, vitamin D, selenium, vitamin B2, 5 and 12, and omega-3 fatty acids. For this study, patients were randomly assigned to eat 12 fortified eggs a week (cooked in whatever manner they chose) or to eat fewer than two eggs of any kind (fortified or not) per week. All patients were 50 years of age or older (the average age was 66 years), half were female and 27% were Black. All patients had experienced one prior cardiovascular event or had two cardiovascular risk factors, such as high blood pressure, high cholesterol, increased BMI or diabetes. The co-primary endpoint was LDL and HDL cholesterol at four months. Secondary endpoints included lipid, cardiometabolic and inflammatory biomarkers and levels of vitamin and minerals. Patients had in-person clinic visits at the start of the study and visits at one and four months to take vital signs and have bloodwork done. Phone check-ins occurred at two and three months and patients in the fortified egg group were asked about their weekly egg consumption. Those with low adherence were provided additional education materials. Results showed a -0.64 mg/dL and a -3.14 mg/dL reduction in HDL-cholesterol ("good" cholesterol) and LDL cholesterol ("bad" cholesterol), respectively, in the fortified egg group. While these differences weren't statistically significant, the researchers said the differences suggest that eating 12 fortified eggs each week had no adverse effect on blood cholesterol. In terms of secondary endpoints, researchers observed a numerical reduction in total cholesterol, LDL particle number, another lipid biomarker called apoB, high-sensitivity troponin (a marker of heart damage), and insulin resistance scores in the fortified egg group, while vitamin B increased. "While this is a neutral study, we did not observe adverse effects on biomarkers of cardiovascular health and there were signals of potential benefits of eating fortified eggs that warrant further investigation in larger studies as they are more hypothesis generating here," Nouhravesh said, explaining that subgroup analyses revealed numerical increases in HDL cholesterol and reductions in LDL cholesterol in patients 65 years or older and those with diabetes in the fortified egg group compared with those eating fewer than two eggs. So why have eggs gotten a bad rap? Some of the confusion stems from the fact that egg yolks contain cholesterol. Experts said a more important consideration, especially in the context of these findings, might be what people are eating alongside their eggs, such as buttered toast, bacon and other processed meats, which are not heart healthy choices. As always, Nouhravesh said it's a good idea for people with heart disease to talk with their doctor about a heart healthy diet. This single-center study is limited by its small size and reliance on patients' self-reporting of their egg consumption and other dietary patterns. It was also an unblinded study, which means patients knew what study group they were in, which can influence their health behaviors. The study was funded by Eggland's Best.

临床结果临床研究

2024-02-06

·PRNewswire

Dermal Repair Complex from Beverly Hills MD Can Help Nourish Dry Skin This Winter

A Dietary Supplement That Supports Visibly Firmer and More Lifted-Looking Skin, A Reduced Appearance of Wrinkles, and Enhanced Radiance BEVERLY HILLS, Calif., Feb. 6, 2024 /PRNewswire/ -- As Winter temperatures begin to drop, many of us find that the cold weather can bring on a set of challenges, particularly for our skin. The harsh winter conditions often leave us grappling with dry skin, causing plump skin cells to shrivel and potentially leading to fine lines and wrinkles. Continue Reading Beverly Hills MD Dermal Repair Complex is a dietary supplement designed to revitalize the look of skin from the inside out. Formulated to address the key causes of dermal breakdown, this supplement aims to help visibly firm and lift the skin, reduce the appearance of wrinkles, enhance radiance, and contribute to a significantly younger and healthier overall appearance. In combating the effects of winter-induced dryness, skincare experts Dr. John Layke and Dr. Payman Danielpour emphasize the importance of constant moisturizing and the potential benefits of dietary supplements. One such supplement is the Beverly Hills MD Dermal Repair Complex. Beverly Hills MD Dermal Repair Complex is a dietary supplement designed to revitalize the look of skin from the inside out. Formulated to address the key causes of dermal breakdown, this supplement aims to help visibly firm and lift the skin, reduce the appearance of wrinkles, enhance radiance, and contribute to a significantly younger and healthier overall appearance. As we bid farewell to winter, it's time to consider incorporating such skincare solutions to help rejuvenate and nourish the skin for the upcoming seasons.†* What is Beverly Hills MD Dermal Repair Complex? Beverly Hills MD Dermal Repair Complex is a dietary supplement crafted with an advanced blend of scientifically-backed nutrients. This formula is designed to aid your body in reducing visible signs of aging by combating the impact of skin-aging hormones, reduced body moisture, and collagen loss. The ingredients in Beverly Hills MD Dermal Repair Complex, including hydrolyzed collagen, hyaluronic acid, MSM, and vitamins A and B, collaborate to help diminish the appearance of wrinkles, crow's feet, pucker lines, forehead creases, and fine lines.†* Over time, users can experience visibly firmer and more lifted-looking skin, particularly in areas prone to the appearance of sagging like the jowls, neck, jawline, cheeks, and chin. Beyond skin nourishment, Beverly Hills MD Dermal Repair Complex can also provide many users with bonus benefits, including thicker-looking hair and fuller-looking lips — enhancing a youthful appearance.* What are the Key Ingredients in Beverly Hills MD Dermal Repair Complex?† Vitamin A: A potent antioxidant that acts as a protective shield against external factors like pollution and stress. It helps address visible signs of aging, including pucker lines, fine lines, crow's feet, and forehead creases.* Vitamin B: As an essential antioxidant, vitamin B supports the healthy turnover of cells, supporting visibly firmer and more lifted-looking skin.* Hyaluronic Acid: Functioning as a moisture-attracting molecule, hyaluronic acid helps visibly smooth wrinkles from the inside out, contributing to a more youthful complexion.* Saw Palmetto: Enriched with antioxidants and fatty acids, Saw Palmetto is a potent extract that helps the body fight the adverse effects of the skin-sagging hormone DHT, leading to noticeable improvements.* MSM (Methylsulfonylmethane): This organic compound works to strengthen the appearance of the skin, promoting a firmer and more radiant look.* Hydrolyzed Collagen: This easily absorbable protein is rich in essential amino acids, working to support the skin's youthful elasticity and achieve a plump, "bouncy" appearance.* The Suggested Use of Beverly Hills MD Dermal Repair Complex For optimal results, take 2 capsules of Dermal Repair Complex dietary supplement daily with 8 fl. oz. of water and a meal. Where to purchase Beverly Hills MD Dermal Repair Complex? Beverly Hills MD Dermal Repair Complex can be purchased on the Beverly Hills MD website for the purchase price of $58.00 with a 90-day money-back guarantee. About Dr. Layke and Dr. Danielpour Dr. John Layke and Dr. Payman Danielpour are renowned plastic surgeons and co-founders of the Beverly Hills Plastic Surgery Group. Both doctors trained at the prestigious Long Island Plastic Surgical Group before offering world-class procedures at their Beverly Hills clinic. In 2014, their passion for science inspired them to develop advanced ingredient formulations to help users achieve results in the comfort of their homes, and the Beverly Hills MD skincare line was born. Dr. John Layke and Payman Danielpour also launched the Forever Young Podcast and Youtube channel where they discuss beauty trends and anti-aging remedies. For more, follow them on Instagram @plastixdocs and TikTok. About Beverly Hills MD Beverly Hills MD was created by co-founders Dr. John Layke and Dr. Payman Danielpour of the innovative Beverly Hills Plastic Surgery Group. Now, with their cutting-edge skincare line, Beverly Hills MD, they're able to reach beyond the walls of their office and offer at-home "look younger" results to those looking for the very best non-surgical, anti-aging solutions available. Each product works to visibly correct the most stubborn skincare concerns. Their bestsellers include Deep Regenerating Stem Cell Moisturizer, Deep Wrinkle Filler, and Beverly Hills MD Rejuv-GH Timeless Beauty Concentrate. For the latest news, follow Beverly Hills MD on Instagram @officialbhmd and YouTube. *All individuals are unique. Your results can and will vary. Media Contact: Shari Mesulam [email protected] SOURCE Beverly Hills MD

2024-01-05

·PRNewswire

ACCP Position Statement: "Hydration and Vitamin Infusion Clinics"

ASHBURN, Va., Jan. 5, 2024 /PRNewswire/ -- The American College of Clinical Pharmacology® (ACCP) published a recent Position Paper entitled "Hydration and Vitamin Infusion Clinics". Hydration and vitamin clinics, so-called "drip clinics", offer vitamin infusions (like vitamin B or C) and intravenous hydration cocktails that its proponents, including celebrities, argue have a variety of uses, including relief from sore muscles, possible hangover cure, treating jet lag, and a general improvement in overall well-being. Often these infusions are administered outside of a hospital or clinic setting and, sometimes, not under medical supervision using vitamins of unknown quality, preparation, and purity. This position statement highlights that these infusions should be given under medical supervision for valid medical reasons, with informed consent related to its benefits and risks, by a licensed and trained individual, be that a physician or other qualified healthcare provider, using pharmaceutical grade products prepared by a licensed pharmacist in a setting suitable for the preparation of intravenous products. Currently these "infusion clinics" are largely unregulated, highlighting the need for greater regulatory oversight. This statement was published to stress the need for greater patient awareness and education concerning the use of hydration clinics that are advertised as "safe" and treated like a spa treatment. These excessively positive advertisements overstate their therapeutic potential and understate their potential safety risks. About ACCP ACCP is a non-profit association providing accredited Continuing Education, publications and career-enhancing opportunities to clinical pharmacology healthcare professionals. SOURCE American College of Clinical Pharmacology

100 项与羟钴胺相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01027	羟钴胺	V03AB33 B03BA03	DB00200

研发状态

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10 条最早获批的记录,

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适应症	国家/地区	公司	日期
氰化物中毒	美国	BTG International, Inc.	2006-12-15
巨幼红细胞性贫血	中国	华润双鹤药业股份有限公司	1996-01-01
巨幼红细胞性贫血	中国	上海锦帝九州药业（安阳）有限公司	1996-01-01
恶性贫血	中国	华润双鹤药业股份有限公司	1996-01-01
恶性贫血	中国	上海锦帝九州药业（安阳）有限公司	1996-01-01
神经痛	中国	华润双鹤药业股份有限公司	1996-01-01
神经痛	中国	上海锦帝九州药业（安阳）有限公司	1996-01-01
维生素B12缺乏症	中国	华润双鹤药业股份有限公司	1996-01-01
维生素B12缺乏症	中国	上海锦帝九州药业（安阳）有限公司	1996-01-01
中毒	美国	Merck & Co., Inc.	1975-04-18

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适应症	最高研发状态	国家/地区	公司	日期
甲基丙二酸血症	临床前	美国	National Institutes of Health	2024-10-09

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04054999 (CTgov)	临床4期	血管麻痹 \| 肝移植排斥反应	19	Hydroxocobalamin (Cyanokit)	鬱網構窪積範鑰鏇獵壓(蓋淵廠餘夢艱顧夢鹹積) = 繭鏇範網醖願糧艱餘網廠簾獵餘築築醖壓願淵 (選夢選衊壓積夢襯鏇膚, 繭衊遞衊蓋壓積築鹹觸 ~ 醖蓋積齋鹹襯醖襯鏇廠) 更多	-	2024-06-24
				Methylene Blue (Methylene Blue)	鬱網構窪積範鑰鏇獵壓(蓋淵廠餘夢艱顧夢鹹積) = 襯鑰蓋衊鏇積積壓鑰淵廠簾獵餘築築醖壓願淵 (選夢選衊壓積夢襯鏇膚, 積窪製積鏇遞獵艱蓋構 ~ 鹹壓積襯繭範淵淵襯積) 更多
NCT03735316 (CTgov)	临床2期	血管麻痹 \| 低血压	8	Cardiopulmonary Bypass+Hydroxocobalamin (B12a)	鹽夢醖鬱獵衊夢鏇觸膚(獵餘蓋顧艱遞鏇製積簾) = 鹽築築製廠積觸壓齋鬱鹽網餘鏇夢醖蓋願餘醖 (鹹廠齋糧製憲淵獵鏇憲, 窪鏇憲網艱窪築鹽網選 ~ 積餘齋遞鹹憲網壓憲蓋) 更多	-	2023-05-10
				Cardiopulmonary Bypass (Placebo)	鹽夢醖鬱獵衊夢鏇觸膚(獵餘蓋顧艱遞鏇製積簾) = 鏇鬱膚窪醖鑰積築繭觸鹽網餘鏇夢醖蓋願餘醖 (鹹廠齋糧製憲淵獵鏇憲, 選壓網壓餘淵製積襯簾 ~ 網壓簾襯鏇窪願糧鏇醖) 更多
IV-HOCSS Trial (Pubmed)	临床2期	脓毒性休克	-	IV-HOC	(糧獵繭糧膚簾艱觸餘廠) = 製遞窪齋窪獵鹹鏇艱憲製繭窪築網積築憲網齋 (淵網鏇繭窪襯顧衊膚鑰 ) 更多	积极	2022-09-26
				Placebo	(糧獵繭糧膚簾艱觸餘廠) = 憲製蓋簾壓壓蓋選選鹽製繭窪築網積築憲網齋 (淵網鏇繭窪襯顧衊膚鑰 ) 更多
SSIEM2022	N/A	Transcobalamin II缺乏症 vitamin B12 \| folic acid \| homocysteine ... 更多	-	Parenteral hydroxocobalamin	遞憲壓艱襯鏇觸膚築艱(鑰鏇製鹽製餘醖艱鏇願) = 淵鏇鏇襯顧鏇襯鬱選積繭窪餘齋襯繭窪壓繭鹹 (淵糧醖壓網繭廠蓋糧窪 ) 更多	-	2022-08-30