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更新于：2025-07-19
Doxylamine Succinate
琥珀酸多西拉敏
更新于：2025-07-19
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式C21H28N2O5 |
InChIKeyKBAUFVUYFNWQFM-UHFFFAOYSA-N |
CAS号562-10-7 |
关联
12
项与 琥珀酸多西拉敏 相关的临床试验CTRI/2025/03/082874
A Comparative Clinical Study on the Effect of Dhanyaka Kalka with Anupana of Sharkara mixed Tandulodaka and doxylamine in Garbhini Chardi - Nil
CTRI/2024/08/072939
A Randomized Comparative Study of Sharbat Tamarhindi Versus Doxylamine Succinate in Emesis Gravidarum (Qay-al-haml) - NIL
CTIS2023-505144-19-00
A prospective, multicentre open-label clinical trial to evaluate the efficacy of the fixed-dose combination of Doxylamine and Pyridoxine 10/10 mg modified-release capsules on the quality of life of pregnant women presenting with nausea and vomiting of pregnancy (NVP). - RES-6131-C1
100 项与 琥珀酸多西拉敏 相关的临床结果
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100 项与 琥珀酸多西拉敏 相关的转化医学
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100 项与 琥珀酸多西拉敏 相关的专利（医药）
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1,111
项与 琥珀酸多西拉敏 相关的文献（医药）2025-07-01Drug Testing and Analysis
Multianalyte Approach—Including Automated Preparation of Calibrators—for Validated Quantification of 82 Drugs in Whole Blood by Liquid Chromatography–Tandem Mass Spectrometry
Article
作者: Keller, Maja ; Poetzsch, Sandra N. ; Steuer, Andrea E. ; Kraemer, Thomas
ABSTRACT:
Bioanalysis, such as the quantification of drugs in different matrices, is of great importance in forensic toxicology. Nowadays, mainly so‐called multianalyte approaches are used given their increased speed and effectiveness. However, such multianalyte procedures can be difficult to develop and maintain with sufficient robustness in the laboratory. One aspect of this is the tedious, manual preparation of spiking solutions containing such a great number of analytes. Therefore, the current study aimed to develop and validate a fast, simple, and robust liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the quantification of 82 classic drugs and to evaluate an alternative autosampler‐assisted automated approach for the preparation of spiking solutions. Simple protein precipitation of 200‐μL whole blood was used followed by analysis by reversed‐phase LC–MS/MS in advanced scheduled multiple reaction monitoring (MRM) mode. The method was fully validated according to international guidelines, including selectivity, recovery, matrix effects, linearity, bias/imprecision, processed‐sample stability, and limits. Validation criteria were fulfilled for all analytes except for buprenorphine and five benzodiazepines. In the context of a multianalyte procedure, a (multipurpose) autosampler‐assisted automatic preparation of calibrator spiking solutions proved comparable to manual preparation. Thus, automated preparation can overcome the frequently performed manual, time‐consuming, and error‐prone steps of multianalyte approaches and still allow for customized calibration ranges. Since its introduction, more than 8000 cases have been measured with the presented method, and 35 proficiency tests have been passed.
2025-03-17CHEMICAL RESEARCH IN TOXICOLOGY
(Q)SAR Approaches to Predict the Extent of Nitrosation in Pharmaceutical Compounds
Article
作者: Chakravarti, Suman ; Saiakhov, Roustem ; Reiss, Krystle
Since their discovery as impurities in numerous pharmaceuticals beginning in 2018, there has been a strong push to predict and prevent the formation of mutagenic nitrosamines. Several experimental methods, particularly the Nitrosation Assay Procedure, have been developed to predict a molecule's susceptibility to nitrosation. Here, we have compiled the results of hundreds of these experiments from the literature to construct two structure-activity relationship models: a statistical model and an expert rule-based model. The statistical model has been built with graph neural networks and was trained on a dataset of 207 nitrogen-containing molecules. This model makes a binary call for each nitrogen center, predicting if it is likely to be nitrosated or not. Conversely, the rule-based model labels each possible nitrosamine product as one of four categories, ranging from "unlikely" to "very likely". It makes this determination based on 15 rules, which cover 12 deactivating (inhibit nitrosation) and 3 activating (favor nitrosation) features that have been drawn from the literature. Both models perform remarkably well, with accuracies of ∼80%. The rule-based model is generally biased toward favoring nitrosation while the statistical model is more likely to classify an amine as un-nitrosatable due to the makeup of the dataset. Using the models together can balance these biases and further improve the reliability of both.
2025-03-01SCIENCE OF THE TOTAL ENVIRONMENT
Assessing pharmaceutical and illicit drugs abuse in a university environment through wastewater analysis
Article
作者: Mateo-Paredes, N M ; Piñaga-Solé, M ; Muñoz-Bartual, M ; Arjona-Mudarra, P ; Garrigues, S ; Esteve-Turrillas, F A
Monitoring the presence of illicit and pharmaceutical drugs in wastewater has emerged as a powerful tool for determining drug consumption patterns and trends within a specific population group. In this study, an analytical method has been developed to determine the presence of forty psychoactive substances, including stimulants, benzodiazepines, antidepressants, and opioids, in wastewater. The proposed approach combines in-situ wastewater single sampling, solid-phase extraction, and ultra-high performance liquid chromatography coupled with tandem mass spectrometry determination. Extraction conditions were evaluated to obtain the best extraction efficiencies and sensitivity. The developed method provided limits of quantification ranging from 1.7 (LSD) to 73.1 (5-EAPB) ng L-1, recoveries from 81 (butylone) to 118 % (diphenhydramine), and relative standard deviations lower than 17 %. More than one hundred wastewater samples were collected at different locations from Campus of Valencia University between 2023 and 2024 for estimating substance consumption by the university community and evaluation of ongoing awareness actions. The results showed the presence of 21 substances in at least one site. Venlafaxine and its main metabolite, escitalopram, and clorazepate were the pharmaceuticals found with the highest occurrence, with concentrations ranging from 15 (clorazepate) to 11,309 ng L-1 (O-desmethylvenlafaxine). Regarding the illicit drugs, cocaine and benzoylecgonine were found in the greatest proportion, with concentrations ranging from 6 to 980 ng L-1 and from 19 to 5699 ng L-1, respectively. From these concentrations the population consumption was calculated, providing the highest mean consumption for venlafaxine and O-desmethylvenlafaxine (489.0 and 37.2 mg day-1 1000 people-1), followed by cocaine, tramadol, MDMA and amphetamine with consumption values of 40.8, 30.9, 30.8 and 17.0 mg day-1 1000 people-1, respectively. The proposed analytical strategy has been demonstrated to be suitable for monitoring the detection frequency of psychoactive substances, providing insight into temporal and spatial trends of drug use through wastewater surveillance.
100 项与 琥珀酸多西拉敏 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 超敏反应 | 美国 | 1948-04-07 | |
| 早孕反应 | 美国 | 1948-04-07 | |
| 入睡和睡眠障碍 | 美国 | 1948-04-07 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 妊娠剧吐 | 临床3期 | 加拿大 | 2006-02-01 | |
| 恶心 | 临床3期 | 加拿大 | 2006-02-01 | |
| 怀孕 | 临床3期 | 加拿大 | 2006-02-01 | |
| 呕吐 | 临床3期 | 加拿大 | 2006-02-01 |
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临床结果
临床结果
适应症
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临床1期 | 20 | 糧窪鬱餘觸鏇顧壓夢襯 = 夢製衊願選鑰積觸繭觸 蓋蓋積糧鬱淵願膚遞膚 (夢壓選選積鏇鹹鑰餘襯, 觸選衊鏇鹽窪鏇壓積網 ~ 糧窪範積鹽衊鬱淵顧製) | - | 2013-09-26 | |||
Intravenous arm (Intravenous Arm) | 衊鹹襯鹹襯鹽選願構鑰 = 鹽觸廠夢淵鬱築膚範窪 淵構鹹憲窪範構範艱蓋 (窪壓製獵淵憲築餘築築, 襯窪鑰衊鏇簾齋窪觸襯 ~ 網積醖窪醖鏇積網齋製) 更多 | ||||||
临床1期 | 41 | (Subjects Aged 2-5 Years) | 蓋構夢構窪糧壓觸繭遞(遞蓋簾夢襯憲夢鹹艱鹹) = 膚鏇蓋築顧積繭衊艱構 壓齋鬱遞願繭窪網築鑰 (選糧糧製鏇繭積簾網鹽, 51.2) 更多 | - | 2013-01-25 | ||
(Subjects Aged 6-11 Years) | 蓋構夢構窪糧壓觸繭遞(遞蓋簾夢襯憲夢鹹艱鹹) = 壓願獵構網鏇遞衊壓鹽 壓齋鬱遞願繭窪網築鑰 (選糧糧製鏇繭積簾網鹽, 27.9) 更多 |
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