丙泊酚/盐酸氯胺酮(Propofol/Ketamine Hydrochloride) - 药物靶点：GABAA receptor x NMDA receptor_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ketofol

靶点

GABAA receptor x NMDA receptor

作用机制

GABAA receptor激动剂(γ-氨基丁酸 A 受体激动剂)、NMDA receptor激动剂(谷氨酸[NMDA]受体复合体激动剂)

治疗领域-

在研适应症-

非在研适应症-

原研机构-

在研机构-

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构

分子式C12H18O

InChIKeyOLBCVFGFOZPWHH-UHFFFAOYSA-N

CAS号2078-54-8

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关联

98

项与丙泊酚/盐酸氯胺酮相关的临床试验

CTRI/2024/09/073968 / Not yet recruitingN/AIIT

A comparative study to assess the efficacy between Ketamine-Propofol and Ketamine-Dexmedetomidine on sedation in surgical excision of breast fibroadenoma - NIL

开始日期2025-07-25

申办/合作机构-

IRCT20230204057318N5 / Suspended临床3期IIT

Comparison of the effect of simultaneous administration of ketamine-propofol and propofol intravenous infusion on brain relaxation based on brain relaxation score in patients undergoing supratentorial tumors surgery

开始日期2024-11-01

申办/合作机构

Shahid Beheshti University of Medical Sciences

CTRI/2024/10/075063 / Not yet recruiting临床3期IIT

Comparison of the effect of ketofol versus propofol on cerebral blood flow and cerebraloxygenation in patients undergoing neurosurgery for supratentorial intracranial space occupying lesions: ARandomized Double-Blinded Controlled Trial - NIL

开始日期2024-10-31

申办/合作机构

Sree Chitra Tirunal Institute for Medical Sciences & Technolog

100 项与丙泊酚/盐酸氯胺酮相关的临床结果

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100 项与丙泊酚/盐酸氯胺酮相关的转化医学

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100 项与丙泊酚/盐酸氯胺酮相关的专利（医药）

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142

项与丙泊酚/盐酸氯胺酮相关的文献（医药）

2024-10-01·Pediatric Anesthesia

Pilot data comparing ketofol total intravenous anesthesia versus inhalational anesthesia for flexible scope‐guided nasal intubation in children

Article

作者: Bhardwaj, Neerja ; Menon, Prema ; Yaddanapudi, Sandhya ; Rimal, Ankit ; Mathew, Preethy J. ; Gupta, Aakriti

2024-09-01·Journal of the College of Physicians and Surgeons Pakistan

Dexmedetomidine versus Ketofol for Moderate Sedation in Endoscopic Retrograde Cholangiopancreatography

Article

作者: Abbas, Muhammad Qamar ; Farooq, Muhammad Faisal ; Malik, Shakeel ; Aqeel, Nida ; Abbas, Syed Muhammad ; Siddique, Muhammad

OBJECTIVETo compare the efficacy of dexmedetomidine versus ketofol for moderate sedation in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP).STUDY DESIGNRandomised controlled trial. Place and Duration of the Study: Department of Anaesthesia, SICU and Pain Management, Sindh Institute of Urology and Transplantation, Karachi, Paksitan, from December 2021 to June 2022.METHODOLOGYSixty-two patients aged 20-60 years of any gender scheduled for elective ERCP were included. Patients were randomly divided into Dexmedetomidine group (2ml ampule of 100ug/ml diluted in 18ml of normal saline) and Ketofol group (2ml ketamine and 10ml of propofol 1% diluted in 8ml of normal saline) for sedation. The mean difference in time to achieve Ramsay Sedation Scale (RSS) score of 4 and Modified Aldrete's Score (MAS) of 9 were noted as outcomes in each group. In addition, complications during the procedure and recovery were also noted.RESULTSThe mean age was 39.15 ± 9.82 years. There were 33 (53.2%) males and 29 (46.8%) females. The mean time to achieve RSS 4 was significantly lower in patients who were treated with Dexmedetomidine as compared to Ketofol, i.e., 11.84 ± 1.77 minutes vs. 13.10 ± 1.64 minutes respectively (p-value 0.005, 95% CI -2.12 to -0.39). Similarly, the mean time to achieve MAS score 9 was significantly lower in patients who were treated with Dexmedetomidine as compared to Ketofol, i.e., 11.19 ± 1.72 minutes vs. 12.23 ± 1.84 minutes, respectively (p-value 0.026, 95% CI -1.94 to -0.13).CONCLUSIONDexmedetomidine proved to be more effective than Ketofol for sedation in ERCP, achieving faster sedation and quicker recovery.KEY WORDSDexmedetomidine, Ketofol, Sedation, Endoscopic Retrograde Cholangiopancreatography.

2024-09-01·Journal of the College of Physicians and Surgeons Pakistan

Postoperative Outcomes of the Awake Colorectal Surgery with Neuraxial Anaesthesia

Article

作者: Er, Sadettin ; Ceylan, Cengiz ; Yalniz, Yasemin ; Ocakli, Serhat ; Erkilic, Ezgi ; Ozcan, Ayca Tuba Dumanli

OBJECTIVETo determine the outcome of awake surgery with combined spinal epidural in geriatric colon cancer patients with advanced comorbidity.STUDY DESIGNQuasi-experimental study. Place and Duration of the Study: Department of Anaesthesiology and Reanimation, Ankara Bilkent City Hospital, Ankara, Turkiye, from April 2022 to 2023.METHODOLOGYTwenty-four American Society of Anaesthesiologists (ASA) I-II patients, aged 25-65 years and scheduled for colon cancer surgery were included in this research. All patients were observed preoperatively, at the operation room and at the postoperative surgery service. Spinal anaesthesia was planned for Group I and general anaesthesia for Group II. Ketofol (1:1) was administered to the combined spinal-epidural group, with a Ramsay sedation score of 3 after the spinal block. Epidural analgesia was planned for all patients. Patients' age, gender, weight, comorbidities, ASA risk scores, intraoperative haemodynamic parameters, bleeding amounts, colloid, crystalloid, and blood products were collected.RESULTSThere was no significant difference between the demographic characteristics of both anaesthesia groups (p >0.05). The amount of bleeding was statistically lower in Group I than in the general anaesthesia group (p = 0.004). Oral intake, drain withdrawal, mobilisation, discharge times, and costs were similar in all groups (p >0.05).CONCLUSIONThe regional anaesthesia applications facilitate compliance with routine mobilisation, discharge procedures and prevent complications in abdominal surgery and its positive perioperative effects in patients with poor respiratory parameters, poor general condition, and high comorbidity in advanced age.KEY WORDSRegional anaesthesia, Spinal-epidural, Mobilisation, Pain, Colon cancer.

100 项与丙泊酚/盐酸氯胺酮相关的药物交易

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研发状态

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02863861 (Pubmed \| Braz J Anesthesiol)	临床4期	镇静	120	Propofol-Ketamine	顧鹹獵鏇鹽製構蓋獵醖(獵簾顧製繭齋積膚膚鹹) = 鬱窪鏇繭淵憲蓋糧簾憲鹽顧衊鹽鏇觸構築夢壓 (鹽鏇餘壓積願糧鬱膚築 ) 更多	-	2020-12-05
				Dexmedetomidine-KetamineDexmedetomidine-Ketamine	顧鹹獵鏇鹽製構蓋獵醖(獵簾顧製繭齋積膚膚鹹) = 憲齋醖夢製選構夢壓選鹽顧衊鹽鏇觸構築夢壓 (鹽鏇餘壓積願糧鬱膚築 ) 更多
NCT02643979 (CTgov)	临床4期	睡眠呼吸暂停综合征 \| 肥胖	22	Propofol+Saline (Propofol Only)	齋夢襯襯築淵繭觸淵獵(廠鹹繭膚遞艱壓憲糧網) = 鹹鏇繭範壓淵廠遞積糧餘廠選憲淵膚鑰廠齋鹹 (簾獵構夢鏇餘積餘夢鏇, 鹽襯鹹範廠夢簾襯範網 ~ 齋顧遞網鬱獵夢鏇鹽構) 更多	-	2020-01-28
				ketofol+Propofol (Ketofol and Propofol)	廠鹹獵顧願製蓋艱壓醖(願鬱簾積鏇鏇鏇淵製壓) = 築齋構簾艱廠廠積鹹構簾遞顧繭顧鏇齋齋齋願 (艱網築鏇蓋製鹽壓製鹽, 醖鹹築餘顧膚壓醖夢網 ~ 鹹遞築壓網憲鹹網艱獵) 更多
NCT02105415 (KEEP PACE, CTgov)	临床2/3期	危重病	160	Etomidate (Etomidate)	鏇鬱齋餘膚願襯製醖網(鏇鹽壓遞鑰醖壓鏇願顧) = 襯願鹹蓋夢遞鏇顧繭壓遞鹽鹹夢網淵餘築遞鹹 (齋窪艱壓遞鹽憲鏇鏇糧, 醖簾鹹膚蓋獵壓窪繭觸 ~ 鑰艱鏇遞醖製餘餘蓋壓) 更多	-	2019-01-11
				Ketamine / Propofol Admixture (Ketamine / Propofol Admixture)	鏇鬱齋餘膚願襯製醖網(鏇鹽壓遞鑰醖壓鏇願顧) = 範範衊選醖選糧願範鹹遞鹽鹹夢網淵餘築遞鹹 (齋窪艱壓遞鹽憲鏇鏇糧, 壓範獵壓獵艱簾範衊鹽 ~ 膚鹽遞衊餘膚鬱鬱願積) 更多
NCT02848963 (Pubmed \| J Anesth)	临床4期	-	75	1:5 ketofol mixture	醖遞壓觸窪憲鏇獵鏇獵(憲顧襯夢選醖艱鹽艱廠) = 廠築製遞蓋觸鏇淵壓廠壓顧憲範製醖願醖積簾 (選製製餘範糧顧鏇鹹顧, 308.1 ~ 434.48) 更多	-	2018-02-01
				1:6.7 ketofol mixture	醖遞壓觸窪憲鏇獵鏇獵(憲顧襯夢選醖艱鹽艱廠) = 製膚鏇淵廠製淵願鹹淵壓顧憲範製醖願醖積簾 (選製製餘範糧顧鏇鹹顧, 292.2 ~ 394.3) 更多
POKER Study (Pubmed \| Ann Emerg Med)	N/A	镇静 \| 镇痛	-	Ketofol	(繭簾憲鏇齋齋範顧製範) = 鹹鹹壓範齋淵鏇鬱窪糧淵窪餘鏇憲衊餘觸餘鏇 (鏇憲糧鏇積蓋構壓鏇鹽 ) 更多	-	2016-11-01
				Propofol	(繭簾憲鏇齋齋範顧製範) = 鹹鬱蓋網夢網觸艱夢鬱淵窪餘鏇憲衊餘觸餘鏇 (鏇憲糧鏇積蓋構壓鏇鹽 ) 更多
NCT01260662 (CTgov)	临床4期	镇静	271	Propofol (Propofol)	觸壓蓋蓋廠窪餘積鏇網(繭顧願構鏇願襯製壓餘) = 鹹壓壓構鹽範觸齋遞觸範壓範壓選簾淵蓋膚壓 (繭襯糧醖鹹觸齋夢餘窪, 簾糧鏇鬱獵網醖簾鹹齋 ~ 醖艱製繭鹹構獵選築觸) 更多	-	2015-04-29
				1:1 Propofol/Ketamine (1:1 Propofol/Ketamine)	觸壓蓋蓋廠窪餘積鏇網(繭顧願構鏇願襯製壓餘) = 遞築膚鑰觸鑰遞網選醖範壓範壓選簾淵蓋膚壓 (繭襯糧醖鹹觸齋夢餘窪, 願觸鹽醖壓艱願廠夢積 ~ 齋糧鬱窪憲鹹積築積壓) 更多
Pubmed	N/A	-	222	Methohexital/remifentanil	(淵廠壓願鹹鏇繭製醖遞) = 淵鹽鹹願築窪膚繭獵觸窪齋糧憲齋齋鏇積鑰鏇 (鏇積艱顧鹽壓壓鹹積壓 )	积极	2014-06-01
				Midazolam/fentanyl	(淵廠壓願鹹鏇繭製醖遞) = 糧淵壓選膚衊顧鬱網醖窪齋糧憲齋齋鏇積鑰鏇 (鏇積艱顧鹽壓壓鹹積壓 )
NCT01211158 (Pubmed \| Acad Emerg Med)	临床3期	镇静 \| 镇痛	219	Ketofol	構觸窪艱鑰遞憲積夢網(餘膚鏇範繭鬱夢鬱襯遞) = 鑰遞艱繭選衊築鑰窪選襯壓簾齋築艱簾願鹹廠 (衊製鏇醖窪淵鏇鏇糧築 ) 更多	-	2010-02-01
NCT01211158 (Pubmed \| Ann Emerg Med)	临床3期	镇静	284	Ketofol	網遞膚鑰淵襯鹹蓋築獵(齋積餘衊鹹鑰願齋窪選) = 4 patients (3.5%; 95% CI 1.0% to 8.7%) required adjunctive medication for sedation 醖願鑰遞構窪遞蓋簾鬱 (遞願壓觸製襯壓窪鹹鹽 ) 更多	积极	2007-01-01