丙泊酚/盐酸氯胺酮(Propofol/Ketamine Hydrochloride) - 药物靶点：GABAA receptor x NMDA receptor_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ketofol

靶点

GABAA receptor x NMDA receptor

作用方式

激动剂

作用机制

GABAA receptor激动剂(γ-氨基丁酸 A 受体激动剂)、NMDA receptor激动剂(谷氨酸[NMDA]受体复合体激动剂)

治疗领域-

在研适应症-

非在研适应症-

原研机构-

在研机构-

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C12H18O

InChIKeyOLBCVFGFOZPWHH-UHFFFAOYSA-N

CAS号2078-54-8

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关联

103

项与丙泊酚/盐酸氯胺酮相关的临床试验

CTRI/2024/09/073968

/ Not yet recruitingN/AIIT

A comparative study to assess the efficacy between Ketamine-Propofol and Ketamine-Dexmedetomidine on sedation in surgical excision of breast fibroadenoma - NIL

开始日期2025-07-25

申办/合作机构-

CTRI/2025/04/085026

/ Not yet recruitingN/AIIT

A Study to compare safety and efficacy of ketamine-dexmedetomidine versus ketamine-propofol in post operative mechanically ventilated patients - NIL

开始日期2025-05-10

申办/合作机构-

CTRI/2025/04/084977

/ Not yet recruiting临床2/3期IIT

A clinical comparative study of etomidate and propofol plus ketamine as an induction agent on quality of proseal laryngeal mask airway insertion and hemodynamic stability in patients undergoing laparoscopic cholecystectomy - Nil

开始日期2025-04-25

申办/合作机构

Lala Lajpat Rai Memorial Medical College

100 项与丙泊酚/盐酸氯胺酮相关的临床结果

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100 项与丙泊酚/盐酸氯胺酮相关的转化医学

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100 项与丙泊酚/盐酸氯胺酮相关的专利（医药）

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150

项与丙泊酚/盐酸氯胺酮相关的文献（医药）

2025-03-01·World Neurosurgery

Comparison of Intraoperative Propofol-Dexmedetomidine and Ketofol-Dexmedetomidine Infusions on Recovery from Anesthesia in Patients Undergoing Endoscopic Transsphenoidal Pituitary Surgeries: A Randomized Controlled Trial

Article

作者: Kaloria, Narender ; Chhabra, Rajesh ; Reddy, Ashwini ; Bhagat, Hemant ; Thappa, Priya ; Panda, Nidhi ; Jangra, Kiran ; Barik, Amiya Kumar ; Soni, Shiv Lal ; Luthra, Ankur ; Mahajan, Shalvi ; Chauhan, Rajeev

BACKGROUNDA rapid and smooth emergence is essential in patients undergoing transsphenoidal pituitary surgeries. Ketofol has been used as an anesthetic agent with good recovery characteristics. We conducted this study to compare the recovery profile of the patients receiving propofol-dexmedetomidine or ketofol-dexmedetomidine infusions for transsphenoidal excision of pituitary tumors.METHODSForty adult patients undergoing endoscopic pituitary surgery received either an infusion of propofol (Group P) or ketofol, 1:5 (Group KP) at 0.6-0.9 ml/kg/h. Dexmedetomidine (0.5 μg/kg/h) was administered in both groups. Our aim was to assess the recovery time, extubation time, and emergence time. We also assessed the intraoperative hemodynamics, cerebral oxygenation, quality of the surgical field, and postoperative pain.RESULTSThe recovery time (Group KP v/s P; 16.5 ± 4.3 vs 8.3 ± 2.7 minutes, P < 0.01), emergence time (12.9 ± 3.9 vs 5.7 ± 2.7 minutes, P < 0.01), and extubation time (14.3 ± 4.2 vs 7.2 ± 2.8 minutes, P < 0.01) were longer in Group KP as compared to Group P. However, the patients in Group KP had lower cough scores and pain scores, along with better maintenance of hemodynamic stability and cerebral oxygenation. The agitation score, cognition score, and quality of the surgical field were comparable.CONCLUSIONSThe use of ketofol resulted in a longer recovery time compared to the use of propofol alone. However, ketofol was associated with a better quality of extubation, maintenance of hemodynamic stability, and enhanced postoperative analgesia. Further research is needed to conclusively establish its efficacy and optimal dosage in pituitary surgery.

2025-02-16·Cureus

Impact of Ketamine and Propofol on Cognitive Function in Elderly Patients: A Systematic Review

Review

作者: Shukla, Pranav S ; Mun, Sojeong ; Chalasani, Roopa ; Van de Vel, Gilles ; Malasevskaia, Iana ; Zia, Shahab Ud Din

Anesthesia has been thought to impact cognitive function in the elderly, although the exact pathophysiology remains uncertain. This systematic review aimed to analyze the impact of ketamine and propofol on cognitive function in elderly patients. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search was conducted across PubMed/Medline, Cochrane Central Register of Controlled Trials (CENTRAL), Europe PMC, ScienceDirect, ClinicalTrials.gov, and EBSCO Open Dissertations on November 17, 2024. After screening, the methodological quality of the included studies was assessed using the Cochrane Risk-of-Bias-2 Tool and the Newcastle Ottawa Scale. Studies were included if they focused on patients aged 60 and older, encompassing 3,149 participants across 19 studies, predominantly randomized controlled trials. Key outcomes assessed included postoperative cognitive dysfunction (POCD) and postoperative delirium (POD). Results indicated that many studies found no significant differences in cognitive outcomes between certain anesthetic drugs. However, ketamine was likely associated with an increased risk of POCD, similar to propofol, when compared to remimazolam and dexmedetomidine. Notably, ketofol reduced POD incidence compared to placebo, while higher propofol doses were linked to an increased incidence, and severity of hypoactive POD. The most evident finding was that propofol attenuated POCD compared to inhaled anesthetic agents. Given this, it is crucial for clinicians to carefully consider anesthetic choices for elderly patients. Future research should focus on larger multicenter trials to further validate these results and explore the long-term cognitive effects of various anesthetic agents.

2025-01-01·Journal of Anaesthesiology Clinical Pharmacology

Comparison between dexmedetomidine and ketofol in the prevention of postoperative emergence delirium in pediatric patients undergoing orofacial cleft surgery: A randomized controlled trial

Article

作者: Sinha, Chandni ; Kumar, Ajeet ; Surabhi ; Kumar, Amarjeet ; Kumari, Poonam ; Singh, Veena K.

AbstractBackground and Aims:Emergence delirium (ED) is a common postoperative complication in pediatric patients. To avoid postoperative ED, sedative medications have been utilized in addition to general anesthesia. In this study, the primary objective was to assess the incidence of postoperative emergence of delirium at 0-, 10-, 20-, 30-, and 60-min intervals. Secondary objective was to assess postoperative analgesia (0, 10, 20, 30, and 60 min) and hemodynamic parameters (mean arterial pressure, pulse, oxygen saturation).Material and Methods:In this randomized controlled study, 105 American Society of Anesthesiologists I and II patients, aged between 3 months and 2 years, scheduled for orofacial cleft surgery were enrolled. Patients of group I received dexmedetomidine (0.3 μg/kg), group II received ketofol (a mixture of ketamine 0.25 mg/kg and propofol 1.0 mg/kg), and group III received normal saline 10 min before extubation. The incidence of postoperative ED using the Watcha scale and the postoperative pain using the Face, Legs, Activity, Cry, Consolability (FLACC) scale were recorded.Results:The Watcha scale at the immediate postoperative period and at 10-, 20-, 30-, and 60-min intervals was 0 (1), 1 (1.75), 1 (1), 2 (2), and 3 (2) in group I, 1 (1), 2 (1), 2 (2), 2 (3), and 3 (2) in group II, and 2 (1), 3 (1), 3 (1.25), 4 (1), and 4.5 (1.5) in group III, respectively, at the above time points. On comparing group I with groups II and III, the difference was significant (P < 0.01). The FLACC score at the immediate postoperative period and at 10-, 20-, 30-, and 60-min intervals was 1 (1), 1 (1), 1 (1), 2 (2), and 3 (2) in group I, 2 (2), 2 (1), 2 (2), 2(3), and 3 (2) in group II, and 4 (1), 3 (1), 3 (1.25), 4 (1), and 4.5 (1.5) in group III, respectively, at the above time points. The FLACC score was also lower in group I in comparison to groups II and III. The difference among the groups was significant (P < 0.01). The incidence of postoperative delirium was lower in group I at 20% (7/35) than in group II at 29% (10/35) and in group III at 49% (17/35), and difference among the groups was significant (<0.01).Conclusions:We conclude that both dexmedetomidine and ketofol are effective in reducing postoperative ED. Dexmedetomidine is more effective than ketofol in preventing postoperative ED in the pediatric population.

100 项与丙泊酚/盐酸氯胺酮相关的药物交易

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研发状态

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02863861 (Pubmed \| Rev Bras Anestesiol)	临床4期	镇静	120	Propofol-Ketamine	醖築膚網鬱膚夢願鹹淵(蓋餘鬱繭鹽鹽衊齋廠艱) = 遞範範餘廠廠網鹹鹹願鬱網顧壓顧構鬱願鬱觸 (範窪願壓簾遞夢餘鏇廠 ) 更多	-	2020-11-01
				Dexmedetomidine-Ketamine	醖築膚網鬱膚夢願鹹淵(蓋餘鬱繭鹽鹽衊齋廠艱) = 鑰鹹鑰鹹鹽鹽夢鹽夢鏇鬱網顧壓顧構鬱願鬱觸 (範窪願壓簾遞夢餘鏇廠 ) 更多
NCT02643979 (CTgov)	临床4期	睡眠呼吸暂停综合征 \| 肥胖	22	Propofol+Saline (Propofol Only)	餘簾夢選網廠艱遞繭積(憲築膚選觸憲廠築壓築) = 選襯憲蓋範繭齋齋鹹鏇鹽廠願獵鑰憲襯糧鑰鬱 (膚壓鑰壓鬱構窪獵積淵, 餘積夢顧襯鬱壓壓鬱網 ~ 積願糧膚淵醖壓繭廠餘) 更多	-	2020-01-28
				ketofol+Propofol (Ketofol and Propofol)	鑰壓醖艱獵顧簾製遞鹹(積製鹹鑰積鹽鏇願壓製) = 鹽鹹觸艱夢積夢範鬱網積鏇夢廠鏇淵鬱膚餘鑰 (艱醖鹹範範餘壓選構鬱, 醖簾選構選窪鬱襯網顧 ~ 淵襯簾選鹽積夢繭繭範) 更多
NCT02105415 (KEEP PACE, CTgov)	临床2/3期	危重病	160	Etomidate (Etomidate)	艱鹽積艱選衊願夢襯壓(製鹽築簾網遞鹽襯製顧) = 齋網蓋簾衊鑰衊製襯淵襯鹹壓夢鏇艱築蓋願遞 (衊衊選憲醖齋餘顧糧窪, 獵獵夢遞蓋範醖繭夢夢 ~ 繭襯鏇簾鏇選範鹽鏇製) 更多	-	2019-01-11
				Ketamine / Propofol Admixture (Ketamine / Propofol Admixture)	艱鹽積艱選衊願夢襯壓(製鹽築簾網遞鹽襯製顧) = 選顧選鹽選壓窪簾鏇膚襯鹹壓夢鏇艱築蓋願遞 (衊衊選憲醖齋餘顧糧窪, 製顧遞選鑰簾簾鑰餘鑰 ~ 襯鑰觸積襯襯廠淵願餘) 更多
NCT02848963 (Pubmed \| J Anesth)	临床4期	-	75	1:5 ketofol mixture	艱鏇繭齋餘鏇願鹹鬱繭(餘淵壓壓鑰簾壓膚餘窪) = 鑰憲窪鏇鏇憲遞網膚網餘築糧顧遞膚憲鑰鹽蓋 (鏇範糧淵構憲構積繭鹹, 308.1 ~ 434.48) 更多	-	2018-02-01
				1:6.7 ketofol mixture	艱鏇繭齋餘鏇願鹹鬱繭(餘淵壓壓鑰簾壓膚餘窪) = 鏇餘淵製餘選壓壓鹹醖餘築糧顧遞膚憲鑰鹽蓋 (鏇範糧淵構憲構積繭鹹, 292.2 ~ 394.3) 更多
ACTRN12610001056088 (POKER Study, Pubmed \| Ann Emerg Med)	N/A	镇静 \| 镇痛	-	Ketofol	(壓鹽遞鬱窪遞鹹繭網艱) = 獵遞夢獵鬱鏇選衊顧壓鹽築淵積鹹範窪獵製簾 (壓醖淵襯壓網艱齋艱糧 ) 更多	-	2016-11-01
				Propofol	(壓鹽遞鬱窪遞鹹繭網艱) = 觸選衊齋築鹹淵衊簾餘鹽築淵積鹹範窪獵製簾 (壓醖淵襯壓網艱齋艱糧 ) 更多
NCT01260662 (CTgov)	临床4期	镇静	271	Propofol (Propofol)	鏇艱衊醖構憲窪構鏇蓋(構鹹積夢願廠鬱廠鬱壓) = 範觸夢壓顧願製淵積廠鬱醖遞築糧鑰鹽鑰鹹襯 (範鑰積壓遞獵醖鹹築選, 夢鹹壓壓繭淵衊鏇積鹽 ~ 鏇襯網衊膚餘壓鏇廠顧) 更多	-	2015-04-29
				1:1 Propofol/Ketamine (1:1 Propofol/Ketamine)	鏇艱衊醖構憲窪構鏇蓋(構鹹積夢願廠鬱廠鬱壓) = 製築膚觸襯壓範蓋積艱鬱醖遞築糧鑰鹽鑰鹹襯 (範鑰積壓遞獵醖鹹築選, 積繭製築築窪膚糧獵網 ~ 艱鹹鏇艱醖鏇襯構糧廠) 更多
NCT01211158 (Pubmed \| Acad Emerg Med)	临床3期	镇静 \| 镇痛	219	Ketofol	蓋顧觸範顧夢壓鑰觸襯(遞蓋膚鹽醖鑰廠糧艱構) = 鹹鏇艱餘遞範糧鹽願蓋鹹網築廠積顧範製鹽遞 (廠淵鹹鏇鹽獵夢範鬱淵 ) 更多	-	2010-02-01
NCT01211158 (Pubmed \| Ann Emerg Med)	临床3期	镇静	284	Ketofol	鏇餘積顧齋淵鏇築艱選(獵鏇選衊膚選壓範淵衊) = 4 patients (3.5%; 95% CI 1.0% to 8.7%) required adjunctive medication for sedation 鏇網蓋繭積鹽鹹網鬱鬱 (製構範淵窪糧襯衊膚夢 ) 更多	积极	2007-01-01