丙泊酚/盐酸氯胺酮(Propofol/Ketamine Hydrochloride) - 药物靶点：GABAA receptor x NMDA receptor_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ketofol

靶点

GABAA receptor x NMDA receptor

作用方式

激动剂

作用机制

GABAA receptor激动剂(γ-氨基丁酸 A 受体激动剂)、NMDA receptor激动剂(谷氨酸[NMDA]受体复合体激动剂)

治疗领域-

在研适应症-

非在研适应症-

原研机构-

在研机构-

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C12H18O

InChIKeyOLBCVFGFOZPWHH-UHFFFAOYSA-N

CAS号2078-54-8

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关联

101

项与丙泊酚/盐酸氯胺酮相关的临床试验

CTRI/2024/09/073968

/ Not yet recruitingN/AIIT

A comparative study to assess the efficacy between Ketamine-Propofol and Ketamine-Dexmedetomidine on sedation in surgical excision of breast fibroadenoma - NIL

开始日期2025-07-25

申办/合作机构-

CTRI/2024/11/077470

/ Not yet recruitingN/AIIT

Comparison of intravenous ketofol (ketamine plus propofol) and ketodex (ketamine plus dexmedetomidine) sedation during awake fiberoptic intubation in patients for cervical spine surgeryA randomized control trial . - nil

开始日期2025-01-01

申办/合作机构-

CTRI/2024/11/076593

/ Not yet recruiting临床4期IIT

A comparative evaluation of the efficacy of ketofol versus the combination of propofol and phenylephrine in maintaining hemodynamic stability during induction of general anaesthesia in patients undergoing neurosurgery - NIL

开始日期2024-11-20

申办/合作机构-

100 项与丙泊酚/盐酸氯胺酮相关的临床结果

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100 项与丙泊酚/盐酸氯胺酮相关的转化医学

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100 项与丙泊酚/盐酸氯胺酮相关的专利（医药）

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147

项与丙泊酚/盐酸氯胺酮相关的文献（医药）

2025-03-01·World Neurosurgery

Comparison of Intraoperative Propofol-Dexmedetomidine and Ketofol-Dexmedetomidine Infusions on Recovery from Anesthesia in Patients Undergoing Endoscopic Transsphenoidal Pituitary Surgeries: A Randomized Controlled Trial

Article

作者: Kaloria, Narender ; Chhabra, Rajesh ; Reddy, Ashwini ; Bhagat, Hemant ; Thappa, Priya ; Panda, Nidhi ; Jangra, Kiran ; Barik, Amiya Kumar ; Soni, Shiv Lal ; Luthra, Ankur ; Mahajan, Shalvi ; Chauhan, Rajeev

BACKGROUNDA rapid and smooth emergence is essential in patients undergoing trans-sphenoidal pituitary surgeries. Ketofol has been used as an anesthetic agent with good recovery characteristics. We conducted this study to compare the recovery profile of the patients receiving propofol-dexmedetomidine or ketofol-dexmedetomidine infusions for trans-sphenoidal excision of pituitary tumours.MATERIALS AND METHODSForty adult patients undergoing endoscopic pituitary surgery received either an infusion of propofol (Group P) or ketofol, 1:5 (Group KP)at 0.6-0.9ml/kg/h. Dexmedetomidine (0.5 μg/kg/ h) was administered in both groups. Our aim was to assess the recovery time, extubation time, emergence time. We also assessed the intraoperative hemodynamics, cerebral oxygenation, quality of the surgical field and postoperative pain.RESULTSThe recovery time (Group KP v/s P; 16.5 ± 4.3 v/s 8.3 ± 2.7 mins, P <0.01), emergence time (12.9 ± 3.9 v/s 5.7 ± 2.7 mins, P<0.01) and extubation time (14.3 ± 4.2 v/s 7.2 ± 2.8 mins, P <0.01) was longer in Group KP as compared to Group P. However, the patients in Group KP had lower cough scores, and pain scores, along with better maintenance of hemodynamic stability and cerebral oxygenation. The agitation score, cognition score, and quality of the surgical field were comparable.CONCLUSIONThe use of ketofol resulted in a longer recovery time compared to the use of propofol alone. However, ketofol was associated with a better quality of extubation, maintenance of hemodynamic stability, and enhanced postoperative analgesia. Further research is needed to conclusively establish its efficacy and optimal dosage in pituitary surgery.

2024-10-01·Saudi Journal of Anaesthesia

Comparison of effects of dexmedetomidine with ketofol and ketofol alone on quality of sedation in pediatric patients undergoing magnetic resonance imaging: A prospective randomized controlled double-blind trial

Article

作者: Kumar, Rakesh ; Bhatia, Pradeep ; Chakravarty, Reena ; Kamal, Manoj ; Goyal, Neha ; Mohammed, Sadik ; Chhabra, Swati

Background and Aim:Patient movement during magnetic resonance imaging (MRI) is the most frequent cause of artifacts and poor scan quality. Children cannot lie still. Thus, anesthesia is required to keep the child calm and immobile. This randomized double-blinded clinical trial compares the clinical effects of the addition of dexmedetomidine as premedication with ketofol on the quality of sedation. We hypothesized that the addition of dexmedetomidine would improve the quality of sedation.Methods:A total of 132 children aged 6 months to 10 years were randomized into groups DK (dexmedetomidine–ketofol) and K (ketofol). DK received an intravenous bolus of dexmedetomidine (0.5 mcg/kg) as premedication 10 minutes prior. Both the groups were induced with ketofol (0.5 mg/kg), and sedation was maintained with propfol infusion (100 mcg/kg/min). The primary objective was the quality of sedation as assessed by the University of Michigan Sedation Scale. Image quality, requirement of rescue propofol dose, recovery, and adverse events were also studied. Data are given as median [interquartile range (IQR)] or frequency.Results:All 132 children completed MRI scans. The DK group showed significantly better quality of sedation, 71% versus 47% of children, a median difference of 1 (-0.569 to -0.0969), P < .005, a better quality of scan, a reduced number of additional doses of propofol, and a decreased total dose of propofol. Hemodynamic parameters and recovery times for the two groups were similar. There were no significant side effects in both groups.Conclusion:The quality of sedation and the quality of the MRI scan are greatly improved by administering dexmedetomidine (0.5 mcg/kg) 10 minutes before to induction. Additionally, this technique decreases the need of propofol and gives better hemodynamic stability without delaying the recovery time.

2024-10-01·Pediatric Anesthesia

Pilot data comparing ketofol total intravenous anesthesia versus inhalational anesthesia for flexible scope‐guided nasal intubation in children

Article

作者: Bhardwaj, Neerja ; Menon, Prema ; Yaddanapudi, Sandhya ; Mathew, Preethy J. ; Gupta, Aakriti ; Rimal, Ankit

100 项与丙泊酚/盐酸氯胺酮相关的药物交易

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研发状态

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02863861 (Pubmed \| Rev Bras Anestesiol)	临床4期	镇静	120	Propofol-Ketamine	繭衊蓋窪網夢鏇襯窪築(構夢構廠鹽餘遞鑰壓網) = 鹽網餘鹹齋齋憲網廠構窪簾遞積遞積網膚餘築 (鏇鹽壓夢鬱窪齋壓糧繭 ) 更多	-	2020-11-01
				Dexmedetomidine-Ketamine	繭衊蓋窪網夢鏇襯窪築(構夢構廠鹽餘遞鑰壓網) = 製鏇襯蓋網糧鹹壓艱艱窪簾遞積遞積網膚餘築 (鏇鹽壓夢鬱窪齋壓糧繭 ) 更多
NCT02643979 (CTgov)	临床4期	睡眠呼吸暂停综合征 \| 肥胖	22	Propofol+Saline (Propofol Only)	淵鏇淵糧構窪鬱淵繭夢(鬱襯築醖艱築蓋簾窪顧) = 積憲網簾鏇艱壓壓夢糧觸鬱衊築窪顧顧構鏇襯 (夢夢獵膚鹹獵繭觸壓襯, 築憲鹹壓淵範網蓋構窪 ~ 醖餘齋遞艱醖製鹹鑰獵) 更多	-	2020-01-28
				ketofol+Propofol (Ketofol and Propofol)	鏇夢艱艱艱顧遞積觸製(夢顧構餘選壓夢壓鬱繭) = 簾遞糧鏇憲襯糧獵鏇膚蓋鏇鹹願觸構獵觸築築 (糧繭憲糧顧衊壓獵鑰餘, 餘齋範觸構齋鬱鏇網遞 ~ 鹽夢積艱顧觸願窪齋廠) 更多
NCT02105415 (KEEP PACE, CTgov)	临床2/3期	危重病	160	Etomidate (Etomidate)	積蓋糧選繭網蓋艱範廠(糧膚選齋製遞憲衊繭醖) = 夢鏇繭醖獵餘網簾鹽構憲淵遞鑰壓觸遞淵餘蓋 (鹽顧鬱網願窪衊蓋淵顧, 齋壓範醖構夢願淵廠窪 ~ 願構鏇衊淵觸衊蓋鑰網) 更多	-	2019-01-11
				Ketamine / Propofol Admixture (Ketamine / Propofol Admixture)	積蓋糧選繭網蓋艱範廠(糧膚選齋製遞憲衊繭醖) = 獵醖衊製鹽獵繭鹽鬱壓憲淵遞鑰壓觸遞淵餘蓋 (鹽顧鬱網願窪衊蓋淵顧, 願廠選鹽獵鬱獵鹽窪鹽 ~ 構觸選顧餘網糧繭鏇鬱) 更多
NCT02848963 (Pubmed \| J Anesth)	临床4期	-	75	1:5 ketofol mixture	築衊衊蓋窪窪顧艱構壓(淵繭鏇願願憲糧膚艱衊) = 淵顧鏇糧遞顧鏇簾膚鑰壓鬱鹽齋簾憲遞醖遞簾 (憲鏇夢範積獵簾廠窪糧, 308.1 ~ 434.48) 更多	-	2018-02-01
				1:6.7 ketofol mixture	築衊衊蓋窪窪顧艱構壓(淵繭鏇願願憲糧膚艱衊) = 廠鏇淵觸選鏇淵願製糧壓鬱鹽齋簾憲遞醖遞簾 (憲鏇夢範積獵簾廠窪糧, 292.2 ~ 394.3) 更多
ACTRN12610001056088 (POKER Study, Pubmed \| Ann Emerg Med)	N/A	镇静 \| 镇痛	-	Ketofol	(積醖蓋簾顧齋顧憲襯願) = 齋觸艱鑰繭鹹齋窪衊鹹襯鹽構壓襯鑰繭簾淵鹹 (襯積廠淵鏇觸淵顧夢鏇 ) 更多	-	2016-11-01
				Propofol	(積醖蓋簾顧齋顧憲襯願) = 齋繭構範襯構鑰膚齋選襯鹽構壓襯鑰繭簾淵鹹 (襯積廠淵鏇觸淵顧夢鏇 ) 更多
NCT01260662 (CTgov)	临床4期	镇静	271	Propofol (Propofol)	鏇構選齋製醖齋遞顧醖(選衊廠齋襯壓觸廠壓糧) = 廠簾壓艱鹹齋蓋憲繭窪願製艱構遞觸廠網糧糧 (顧衊衊鏇齋顧鑰夢蓋齋, 鹹膚選糧構鹹製顧餘鬱 ~ 顧餘觸觸廠製襯顧獵選) 更多	-	2015-04-29
				1:1 Propofol/Ketamine (1:1 Propofol/Ketamine)	鏇構選齋製醖齋遞顧醖(選衊廠齋襯壓觸廠壓糧) = 觸壓鏇顧觸齋窪壓簾襯願製艱構遞觸廠網糧糧 (顧衊衊鏇齋顧鑰夢蓋齋, 衊廠獵顧夢積鬱繭獵獵 ~ 淵築鬱餘糧顧獵鹹膚鏇) 更多
NCT01211158 (Pubmed \| Ann Emerg Med)	临床3期	镇静	284	Ketofol	構襯醖淵鹽艱淵鏇積壓(鏇鏇襯積構夢糧遞艱艱) = 4 patients (3.5%; 95% CI 1.0% to 8.7%) required adjunctive medication for sedation 遞餘鏇艱餘醖觸壓蓋壓 (願憲網窪憲餘鬱繭窪窪 ) 更多	积极	2007-01-01