Recombinant staphylokinase(Supergene Co. Ltd.)(Recombinant staphylokinase(Supergene Co. Ltd.)) - 药物靶点：PLG_在研适应症：急性肺损伤，肢体缺血，肺栓塞_专利_临床

概要

基本信息

药物类型

酶

别名

Fortelyzin、Forteplase、Gene modified staphylokinase

+ [3]

靶点

PLG

作用机制

PLG刺激剂(纤溶酶原刺激剂)

治疗领域

心血管疾病呼吸系统疾病其他疾病

在研适应症

急性肺损伤肢体缺血肺栓塞

非在研适应症

急性缺血性卒中新型冠状病毒感染ST段抬高心肌梗死

原研机构

Supergene Co., Ltd.

在研机构

Supergene Co., Ltd.

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

7

项与 Recombinant staphylokinase(Supergene Co. Ltd.) 相关的临床试验

NCT06362746

/ Recruiting临床3期

Multicenter, Double-blind, Randomized, Placebo-controlled Trial of the Efficacy and Safety of a Single Bolus Administration of Non-immunogenic Recombinant Staphylokinase in Patients With Intermediate High-risk Pulmonary Embolism (FORPE-2)

Objective: to evaluate the efficacy and safety of the non-immunogenic recombinant staphylokinase with its single bolus administration in comparison with placebo in normotensive patients with intermediate high-risk pulmonary embolism (PE)

开始日期2024-05-23

申办/合作机构

Supergene Co., Ltd.

NCT05372718

/ Recruiting临床3期

Multicenter, Open-label, Randomized Clinical Trial of Efficacy and Safety of the Thrombolysis With Recombinant Non-immunogenic Staphylokinase (Fortelyzin®) in Patients With ALI vs Surgery

Objective: to evaluate the efficacy and safety of intra-arterial intrathrombus administration of the recombinant non-immunogenic staphylokinase (Fortelyzin®) in patients with acute limb ischemia (ALI) vs surgery.

开始日期2022-12-26

申办/合作机构

Supergene Co., Ltd.

NCT05135546

/ Terminated临床2/3期

Inhaled Recombinant Non-immunogenic Staphylokinase vs Placebo in Patients With COVID-19 - FORRIF Trial

Objective: to evaluate the tolerability, safety and efficacy of inhaled usage of the Recombinant Non-immunogenic Staphylokinase (Fortelyzin®) vs placebo in patients with COVID-19.

开始日期2021-12-27

申办/合作机构

Supergene Co., Ltd.

[+1]

100 项与 Recombinant staphylokinase(Supergene Co. Ltd.) 相关的临床结果

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100 项与 Recombinant staphylokinase(Supergene Co. Ltd.) 相关的转化医学

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100 项与 Recombinant staphylokinase(Supergene Co. Ltd.) 相关的专利（医药）

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8

项与 Recombinant staphylokinase(Supergene Co. Ltd.) 相关的文献（医药）

2024-10-01·JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Non-immunogenic recombinant staphylokinase versus alteplase for patients with massive pulmonary embolism: a randomized open-label, multicenter, parallel-group, non-inferiority trial, FORPE

Article

作者: Kulabukhov, Vladimir V. ; Omelchuk, Alexander M. ; Orlov, Bogdan B. ; Imad, Merai ; Soplenkova, Anna G. ; Solovyeva, Natalya V. ; Tarkhanov, Roman V. ; Komarnitskaya, Mariya I. ; Konstantinov, Sergey L. ; Kulibaba, Elena V. ; Yavelov, Igor S. ; Shogenov, Zaur S. ; Vyshlov, Eugene V. ; Kirienko, Alexander I. ; Leontyev, Stanislav G. ; Agirov, Murad M. ; Bogomazov, Ivan Yu ; Savvinova, Polina P. ; Veremeychuk, Petr V. ; Shakhnovich, Roman M. ; Bobkov, Vladimir V. ; Kashtalap, Vasily V. ; Vlasov, Petr N. ; Mullova, Irina S. ; Yasnopolskaya, Natalya V. ; Tolmacheva, Valeria Yu ; Yu Chefranova, Zhanna ; Sorokina, Anna S. ; Archakov, Alexander I. ; Furman, Nikolai V. ; Talibov, Oleg B. ; Karabach, Yuriy V. ; Ponomarev, Eduard A. ; Maksimov, Dmitry B. ; Rybin, Eugene V. ; Teterina, Marina A. ; Kutsenko, Vladimir A. ; Ivanov, Sergey V. ; Lykov, Yury A. ; Koledinskii, Anton G. ; Pribylov, Sergey A. ; Panina, Elena S. ; Libov, Igor A. ; Komissarova, Ekaterina V. ; Tereschenko, Sergey N. ; Pecherina, Tamara B. ; Zolkin, Vladimir N. ; Erlikh, Alexey D. ; Cherepanova, Natalya A. ; Ludnev, Leonid O. ; Linev, Kirill A. ; Kurtasov, Dmitry S. ; Yu Vasilieva, Elena ; Igoshin, Alexander S. ; Markin, Sergey S. ; Oleynikov, Valentin E. ; Klein, Harry V. ; Makukhin, Valery V. ; Avdeeva, Irina A. ; Semenov, Michail P. ; Duplyakov, Dmitry V. ; Stryabkova, Galina I. ; Semenov, Andrey M. ; Ivlev, Oleg E. ; Ivanov, Vladimir S. ; Vyazova, Natalia L. ; Beregovykh, Valery V. ; Yarovaya, Elena B. ; Rabinovich, Robert M. ; Komarova, Anna G.

2023-01-01·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

[Multicenter experience of using Fortelyzin during staged reperfusion therapy of acute ischemic stroke in anterior circulation].

Article

作者: Mingazetdinov, M A ; Telyatnik, Yu A ; Yusupov, R I ; Demin, T V ; Mukhamadieva, Y S ; Zagidullin, B I ; Timchenko, L V ; Sinutin, V N ; Volodyukhin, M Yu ; Khasanova, D R ; Podshivalov, I A

2022-01-01·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

Nonimmunogenic staphylokinase in the treatment of acute ischemic stroke (FRIDA trial results)

Article

作者: Nesterova, V N ; Nikonova, A A ; Choroshavina, K V ; Kutsenko, V A ; Bobkov, V V ; Martynov, M Yu ; Korobeynikov, I V ; Yunevich, D S ; Semenov, M P ; Shamalov, N A ; Yarovaya, E B ; Popov, D V ; Lykov, Yu A ; Zhukovskaya, N V ; Gorbachev, V I ; Semenov, A M ; Ponomarev, E A ; Chefranova, Zh Yu ; Korsunskaya, L L ; Semikhin, A S ; Nikonov, A A ; Timchenko, L V ; Dobrovolskiy, A V ; Orlovsky, A A ; Markin, S S ; Fedyanin, S A ; Pribylov, S A ; Gusev, E I ; Jadan, O N ; Alasheev, A M ; Aksentiev, S B ; Chirkov, A N ; Androfagina, O V ; Nizov, A A ; Zakharov, S A ; Vorobev, A A ; Archakov, A I ; Greshnova, I V ; Elemanov, U A ; Chuprina, S E ; Girivenko, A I

100 项与 Recombinant staphylokinase(Supergene Co. Ltd.) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
急性肺损伤	临床3期	俄罗斯	Supergene Co., Ltd.	2022-12-26
肢体缺血	临床3期	俄罗斯	Supergene Co., Ltd.	2022-12-26
新型冠状病毒感染	临床3期	俄罗斯	Supergene Co., Ltd.	2021-12-27
肺栓塞	临床3期	俄罗斯	Supergene Co., Ltd.	2020-12-15
急性缺血性卒中	临床3期	俄罗斯	Supergene Co., Ltd.	2017-03-18
ST段抬高心肌梗死	临床3期	俄罗斯	Supergene Co., Ltd.	2014-10-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03151993 (FRIDA, Pubmed \| Lancet Neurol)	临床3期	急性缺血性卒中	336	Non-immunogenic staphylokinase	觸構艱壓襯繭網製構窪(網膚廠遞淵夢構夢鑰淵) = 襯夢鹹鹹齋壓鬱廠鬱積遞鹹鹽簾積繭鹽夢鏇醖 (夢窪憲襯獵範繭築網願 ) 更多	积极	2021-09-01
				Alteplase	觸構艱壓襯繭網製構窪(網膚廠遞淵夢構夢鑰淵) = 觸憲遞鏇鹹窪簾製夢選遞鹹鹽簾積繭鹽夢鏇醖 (夢窪憲襯獵範繭築網願 ) 更多