预约演示
更新于：2026-08-06
Tenecteplase
替奈普酶
更新于：2026-08-06
概要
基本信息
原研机构 |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-06-02), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
Sequence Code 431641667
来源: *****
关联
149
项与 替奈普酶 相关的临床试验NCT07621796
Efficacy and Safety of Tenecteplase Among acutE Ischemic Stroke Patients With Recent Ingestion of Direct Oral Anticoagulant (ESTER-DOAC)
The study will randomize patients with acute ischemic stroke and Direct Oral AntiCoagulants (DOAC) ingestion within 48 hours from enrollment (but otherwise eligible for thrombolysis) to administration of intravenous tenecteplase vs. placebo (1:1).
Participants will be enrolled at NIH StrokeNet sites across the US and followed for 90-days.
The primary aim is to determine the efficacy of intravenous tenecteplase (TNK) vs placebo among acute ischemic stroke patients and to determine the safety of TNK among acute ischemic stroke patients within 4.5 hours of last known well who used DOAC within 48 hours prior to thrombolysis. Efficacy and safety endpoints will be the focus of this proposed Phase III study.
Participants will be enrolled at NIH StrokeNet sites across the US and followed for 90-days.
The primary aim is to determine the efficacy of intravenous tenecteplase (TNK) vs placebo among acute ischemic stroke patients and to determine the safety of TNK among acute ischemic stroke patients within 4.5 hours of last known well who used DOAC within 48 hours prior to thrombolysis. Efficacy and safety endpoints will be the focus of this proposed Phase III study.
开始日期2027-01-01 |
NCT06696131
Tenecteplase (TNK) in the Treatment of Intracerebral Hemorrhage (ICH)
The overall purpose of this study is to look at the safety and effectiveness of administering Tenecteplase (TNK) into the brain bleed (hematoma) instead of another clot-dissolving drug known as recombinant tissue plasminogen activator (rtPA), which is the current standard practice. Clot dissolving (Fibrinolytic) drugs work to break down blood clots and have been found to improve health outcomes when applied directly into the hematoma within the brain. Patients who take part in this study will undergo the same surgical procedure that would normally be performed to treat them, but with the exception of TNK not rtPA.
开始日期2026-09-15 |
申办/合作机构 |
NCT07606807
rhTNK-tPA for Acute Ischemic Stroke Under Simplified Imaging in the Extended Time Window: A Multicenter, Prospective, Randomized Controlled, Open-label, Blinded-Endpoint Trial
The PEARL-SIMPLIFIED trial is a multicenter, prospective, randomized controlled, open-label, blinded-endpoint study. It aims to evaluate the efficacy and safety of intravenous tenecteplase (TNK) in patients with acute ischemic stroke (AIS) presenting in the extended 4.5-24 hour window, using a simplified imaging selection strategy based solely on non-contrast CT (NCCT).
开始日期2026-08-01 |
申办/合作机构 |
100 项与 替奈普酶 相关的临床结果
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100 项与 替奈普酶 相关的转化医学
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100 项与 替奈普酶 相关的专利（医药）
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1,086
项与 替奈普酶 相关的文献（医药）2026-09-01·JOURNAL OF THE NEUROLOGICAL SCIENCES
Shifting from alteplase to tenecteplase in acute ischemic stroke: Progress, promise, and perils
Letter
作者: Vitturi, Bruno Kusznir ; Gagliardi, Rubens José
2026-08-01·JOURNAL OF EMERGENCY MEDICINE
Repeat Intravenous Tenecteplase for Posterior Circulation Stroke Without Completed Infarction
Article
作者: Burnham, Kevin ; Saherwala, Ali ; Pieniazek, Noah ; Singh, Michael
BACKGROUND:
Intravenous thrombolysis is traditionally avoided in patients with early recurrent acute ischemic stroke due to concerns for increased hemorrhagic risk. Although emerging evidence suggests that repeat intravenous thrombolysis may be safe in selected patients, nearly all published cases involve alteplase, with limited data on repeated use of tenecteplase.
CASE REPORT:
A 39-year-old woman with no prior medical history presented with acute posterior circulation stroke symptoms following cervical chiropractic manipulation and was found to have a right vertebral artery dissection. She received intravenous tenecteplase with rapid neurologic improvement and no evidence of completed infarction on magnetic resonance imaging. Five days later, she re-presented with sudden-onset diplopia, obtundation, and signs concerning for brainstem ischemia. Imaging demonstrated diminished basilar artery flow concerning for occlusion. Given disabling symptoms and absence of established infarction, repeat intravenous tenecteplase was administered approximately 140 h after the initial dose, resulting in rapid neurologic recovery and restoration of posterior circulation flow. She experienced no thrombolysis-related complications and was discharged neurologically intact. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Early recurrent stroke presents a diagnostic and therapeutic challenge in the emergency department, particularly in patients with posterior circulation symptoms and recent thrombolytic exposure. This case demonstrates that, in carefully selected patients with disabling symptoms and no completed infarction, repeat intravenous tenecteplase may be a viable treatment option, highlighting the importance of timely neurologic assessment, vascular imaging, and multidisciplinary decision-making.
2026-08-01·CNS DRUGS
Tenecteplase Beyond the 4.5-h Window for Patients with Acute Ischemic Stroke: An Updated Meta-Analysis of Randomized Controlled Trials
Review
作者: Nguyen, Thanh ; Portela, João Gabriel Silva ; Scarcia, Luca ; Cardoso, Leonardo Januario Campos ; Almeida, Kelson James ; de Bastos Maximiano, Mariana Letícia ; Santos, Gabriel Soares Bruno ; de Melo Neto, Altair Pereira ; Falcão, Luciano ; Porto, Luis Felipe Vieira Nunes ; Sanders, João Victor ; Günkan, Ahmet ; Gonçalves, Ocílio Ribeiro ; da Silva, Anderson Matheus Pereira ; Clarençon, Frédéric
INTRODUCTION:
Intravenous thrombolysis (IVT) is the established treatment for acute ischemic stroke (AIS) when administered within 4.5 h of the last known well (LKW) status. However, this narrow therapeutic window limits the number of patients eligible for treatment. In this context, tenecteplase (TNK) is being investigated as an alternative thrombolytic agent in the extended time window.
OBJECTIVE:
The objective of this study was to evaluate the safety and efficacy of intravenous TNK in patients with AIS treated in the extended time window (beyond 4.5 h from LKW) compared with best medical treatment (BMT) without IVT.
METHODS:
We conducted a systematic literature review and meta-analysis of patients with AIS presenting beyond 4.5 h from LKW treated with TNK or BMT in randomized controlled trials (RCTs). The safety outcomes included: (1) symptomatic intracranial hemorrhage (sICH), (2) mortality at 90 days, (3) any intracranial hemorrhage (ICH), and (4) parenchymal hemorrhage type 2 (PH2). The efficacy outcomes included: (1) excellent functional outcome (modified Rankin scale [mRS] 0-1) at 90 days, (2) functional independence (mRS 0-2) at 90 days, and (3) early neurological improvement. An analysis based on odds ratios (OR) with 95% confidence intervals (CI) under a random-effects model was used for data pooling. Heterogeneity was assessed using the Q test and its P-value, with the magnitude evaluated by I2 values.
RESULTS:
A total of 6 RCTs including 2297 patients were analyzed, with 1152 patients receiving TNK and 1145 receiving BMT. Compared with BMT, TNK administered in the extended time window was associated with significantly higher rates of excellent functional outcomes (mRS 0-1: OR 1.40, 95% CI 1.18-1.67; P < 0.001), functional independence (mRS 0-2: OR 1.27, 95% CI 1.07-1.51; P = 0.006), and early neurological improvement (OR 3.21, 95% CI 1.82-5.66; P < 0.001). TNK was associated with a significant increase in sICH (OR 2.34, 95% CI 1.11-4.95; P = 0.026). No significant differences were observed in 90-day mortality (OR 1.17, 95% CI 0.89-1.55), any ICH (OR 1.61, 95% CI 0.37-6.95), or PH2 (OR 1.81, 95% CI 0.90-3.64).
CONCLUSIONS:
In patients with AIS treated beyond 4.5 h from symptom onset, intravenous TNK significantly improves functional outcomes and early neurological recovery compared with BMT, without a significant increase in mortality. Although sICH was significantly increased, absolute rates remained low. These findings support the potential role of tenecteplase as an effective thrombolytic option in the extended time window for carefully selected patients.
REGISTRATION:
PROSPERO identifier no. CRD420251060492.
173
项与 替奈普酶 相关的新闻（医药）2026-07-30
RESEARCH TRIANGLE, N.C., July 30, 2026 /PRNewswire/ -- Basking Biosciences (Basking), a clinical-stage biopharmaceutical company developing a first-in-class, targeted, reversible thrombolytic therapy for acute ischemic stroke (AIS), today announced the publication of preclinical research in Communications Biology, a Nature Portfolio journal. The study shows that its lead candidate, BB-031, restores blood flow in a microfluidic model of arterial occlusion using blood samples from AIS patients by selectively inhibiting von Willebrand Factor (vWF), a key mediator of clot initiation, growth and stabilization. The research was led by scientists at the University of Pittsburgh and The Ohio State University.
The study evaluated how BB-031 reopens vessels and compared its performance with the two approved fibrinolytics, alteplase (tPA) and tenecteplase (TNK). In the model, fully occlusive, platelet-rich clots were formed under arterial flow conditions, allowed to mature for up to six hours, and then treated. Results showed that BB-031 restored blood flow through occluded channels more effectively than both alteplase and tenecteplase, including clots that had matured for three to six hours. BB-031 also worked by preventing vWF from recruiting new platelets to the clot surface, a process that continually reinforces platelet-rich arterial clots and makes them resistant to current fibrinolytics.
"The model allowed us to see what may be happening to arterial clots in prolonged settings, providing a closer analog to clinical reality. This advance allowed us to better interrogate the potential advantages of a vWF-targeting strategy, complementing our earlier studies," said Susan M. Shea, M.S.M.E., Ph.D., Assistant Professor in the Trauma and Transfusion Medicine Research Center, Department of Surgery at the University of Pittsburgh and senior author on the study.
Blood samples from AIS patients showed restored blood flow with BB-031 compared with the vehicle. Importantly, clots formed in the model reproduced the clot composition reported in human samples from patients who have undergone endovascular thrombectomy (EVT). These include fibrin, platelets, and vWF, supporting the model as a relevant system for studying arterial thrombosis and treatment.
"These findings show that BB-031 restores blood flow in an occlusive thrombus after a clot has already formed and matured," said Shahid M. Nimjee, M.D., Ph.D., co-founder, chief scientific officer and stroke clinical lead of Basking Biosciences. "Von Willebrand Factor continually recruits platelets that reinforce arterial clots, thereby engendering resistance to current therapies. By selectively inhibiting vWF, BB-031 stops that reinforcement and allows blood flow to return, even when treatment is administered hours after the occlusion forms. This gives us clear insight into how BB-031 works in human clot formation and strengthens the rationale for our clinical program in acute ischemic stroke."
Stroke remains one of the leading causes of death and disability worldwide. Fibrinolytics, the pharmacological standard of care since 1996, are limited by a narrow 3- to 4.5-hour treatment window and a serious bleeding risk. Mechanical thrombectomy, adopted globally in 2015, can extend treatment up to 24 hours, but it is available only in specialized centers. Current literature supports limiting it to patients who present with large vessel occlusion stroke. BB-031 offers a different approach. It selectively and reversibly inhibits vWF and can be paired with BB-025, a direct-acting reversal agent designed to rapidly restore normal hemostasis within minutes, if needed, enabling potential urgent surgical intervention in the event of bleeding.
"This publication adds important mechanistic evidence to our program, and it is encouraging to see our approach validated in blood samples from stroke patients," said Julia C. Owens, Ph.D., chief executive officer of Basking Biosciences. "Findings like these strengthen our conviction as we advance BB-031 through our Phase 2 RAISE trial and work toward a treatment that could reach many stroke patients who do not currently receive acute treatment."
The Phase 2 RAISE trial is a multicenter, randomized, double-blind, dose-finding study evaluating BB-031 versus placebo in patients with AIS who present within 24 hours of symptom onset. The trial includes two parts. Part A was completed in 2025. Part B will enroll approximately 180 patients. The trial is being conducted at sites across North America and Australia, with additional site activation planned. The full manuscript, titled "Von Willebrand factor A1 blockade prevents platelet-mediated sustained occlusion for the treatment of arterial thrombosis," is available at
About BB-031
BB-031 is an investigational RNA aptamer designed to selectively inhibit von Willebrand Factor (vWF), a central mediator of clot initiation, growth and stabilization. By targeting vWF with high affinity and selectivity, BB-031 is intended to enable potent inhibition of this key element of clot stabilization, resulting in rapid restoration of blood flow that could extend the treatment window and broaden treatment opportunities for patients with acute ischemic stroke (AIS). In the event of bleeding or the need for urgent surgical intervention, BB-025 can be administered to neutralize BB-031.
About BB-025
BB-025 is an investigational, rapid-acting oligonucleotide reversal agent that specifically binds to BB-031. Administered as a single intravenous bolus, BB-025 is designed to rapidly and durably reverse BB-031's thrombolytic activity. By delivering immediate, durable neutralization of BB-031, BB-025 is being developed to provide clinicians with a built-in safety mechanism that can reverse BB-031's thrombolytic activity in the event of bleeding or the need for urgent surgical intervention.
About Acute Ischemic Stroke
Acute Ischemic Stroke (AIS) is the leading cause of combined mortality and morbidity worldwide, accounting for 87 percent of all strokes. According to the World Health Organization, 15 million people suffer a stroke each year, resulting in more than 5 million deaths. Currently available therapies, including intravenous thrombolytics and mechanical thrombectomy, reach no more than 20 percent of patients, even in the best stroke centers.
About Basking Biosciences
Basking Biosciences is a clinical-stage biopharmaceutical company dedicated to changing the way potentially life-threatening blood clots are treated. Its novel therapies are designed to significantly improve safety and efficacy, broadening access to many more patients. The company's lead candidate, BB-031, is the first rapid-onset, short-acting thrombolytic therapy with a direct-acting reversal agent, currently in development for the treatment of acute ischemic stroke. By selectively inhibiting von Willebrand Factor (vWF), a central mediator of clot initiation, growth, and stabilization, BB-031 delivers potent, targeted thrombolytic activity that, together with its reversal agent BB-025, could enable more patients to receive timely, life-saving treatment after stroke. For more information, visit and follow us on LinkedIn.
SOURCE Basking Biosciences Inc.
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临床2期寡核苷酸
2026-07-27
药企医学部制作药物临床对比市场材料，是连接研发成果与商业价值的关键桥梁。这一过程不仅关乎学术推广的合规与专业，更直接影响药品的市场准入及商业化前景。
一、 制作临床对比材料的核心路径
医学部在制作此类材料时，通常需要遵循严谨的科学逻辑与合规流程，主要路径包括以下几个关键环节：
1. 深度调研与竞品摸底
制作对比材料的第一步是“摸清家底”。医学部需要全面收集目标适应症下的竞品数据，包括查阅国内权威指南、药监局官网信息、已发表的最新文献综述（Review）以及临床试验进度等2。同时，需梳理竞品在机制、剂型、用量、药代动力学、获批适应症以及关键三期研究终点（如疗效和安全性数据）等方面的核心信息24。
2. 确立科学的对照药（参照药）标准
选择正确的对照药物是临床对比的灵魂。医学部需明确，药监体系的参照药（如一致性评价的参比制剂）与医保体系的参照药（药物有效性与安全性方面）存在差异。在对比时，应优先锚定医保支付范围内、临床应用最广泛且同治疗领域的现有品种，避免盲目选择最新、最贵的药物以操纵溢价，或误用安慰剂作为价值参照。
3. 构建多维度的综合评价体系
现代药品的临床对比早已超越了单一的疗效比拼，而是基于循证医学证据进行多维度整合分析。医学部需围绕六大核心维度展开评估：临床有效性、临床安全性、临床适用性、可及性以及社会价值。
4. 严谨的医学写作与合规质控
在材料撰写阶段，医学写作团队需对靶点、疾病领域及试验设计有深入理解。必须确保引用的文献数据准确标注出处，严禁夹带未经证实的主观营销表述（如“显著优于”、“远超竞品”等）。所有输出内容需经过严格的合规审核，确保符合相关质量管理规范，做到全流程留痕可追溯。
5. 提炼核心价值主张（VCP）与差异化定位
基于详实的临床数据对比，医学部能够提炼出新药独特的、具有说服力的核心价值主张，清晰回答“为什么医生和患者应该选择这款药”4。这有助于新药在激烈的市场竞争中形成差异化形象，精准确立其在治疗体系中的地位（如一线、二线或联合用药）。
6. 赋能一线学术推广与KOL沟通
结构化的临床对比材料（如临床数据手册、医学概要等）为医学联络官（MSL）和市场团队提供了坚实的学术弹药。通过数字化医学内容库和智能问答系统，医学部能高效、精准地向临床医生传递跨适应症的用药证据链，支持KOL的培养与高水平学术活动的开展。
二、药物临床对比材料的制作
传统的药物临床对比，需要检索大量的文献及临床试验结论。需要MSL或医学经理花费大量时间进行资料整理，同时对于不同临床试验需要分组剂型对比。
对于临床试验的总体维度遵循：
试验设计
基线
有效性
安全性
按照这样的对比维度，我们可以完成临床试验科学数据的比较。
但是并不是所有临床试验都能直接拿来比较，我们需要区分一下几类试验设计。
第一优先：头对头（最高级别证据）,目标药物与阳性药物直接临床证据
第二优先：一线对照，目标药物与一线疗法的临床试验，对比阳性药物与一线疗法的临床试验
第三优先：后线单药单臂，目标药物与阳性药物，均存在后线的单药临床试验
第四优先：安慰剂对照，目标药物与阳性药物，各自的安慰剂对照试验进行临床对比
我们必须要对临床试验进行分组，才能够合理的评价出药物疗效不良反应之间的差异。
我们以现在市场上比较火的双抗药物依沃西单抗与K药物的临床对比分析为例，使用药番茄临床对比工具。可以自动对临床试验进行分组，以确定相同的临床试验设计进行对比。
依沃西单抗 VS 帕博丽珠单抗（非小细胞肺癌，以三期临床作为主要评估）
对于不同的分组，药番茄临床对比平台可以直接列出对比表格，极大的方便MA同事的工作量。
最后所有对比内容均有完整的数据支持与结论，帮助医学部同事形成完善的学术营销资料。
对于肿瘤药物而言，新药不断，可以使用药番茄临床对比平台直接获取药物临床对比分析报告，每个内容都有严肃的数据源作为循证。
对于溶栓药物美通立与明复乐，一直是2大直接对标的产品，一个石药集团产品，另一个为勃林格殷格翰产品，两者在药物市场上形成了明确的竞对。
美通立 VS 明复乐（急性缺血卒中，以三期临床作为主要评估）
对于基线、有效性、安全性分析，可以直接通过药番茄平台直接得出结论。
疗效要点：美通立提供了可引用的精确主终点率与非劣效统计量；明复乐提供了 Lancet 级 TRACE-2 非劣效确证与国产 AIS 适应症注册路径。二者均未显示需改写“可替代阿替普酶”定位的劣效信号。
不良反应要点： 关键关注的 sICH、严重出血与死亡在 0.25 mg/kg AIS 公开结论层未显示相对阿替普酶的系统性恶化；高剂量卒中路径与 PE 全剂量溶栓标出出血上限，应用于外推边界，而非主场景下的商品名排名。
局限性：主结论来自间接比较而非两药直接随机；人群 EVT 排除条款、基线与部分安全分项披露不完整；桥接、超窗、STEMI、PE 等无法在本报告内完成美通立 vs 明复乐的配对读出。
前瞻：后续应跟踪双方桥接/取栓相关 III 期结果、补齐 TRACE-2 与 ORIGINAL 的完整终点与基线表，并在有真正策略对齐数据时再考虑扩展第二主对比组。在现有证据下，不宜宣称某一制剂在溶栓疗效或不良反应上整体优于另一制剂；实践分化应更多结合可及性、供应与流程落地综合判断。
你只需要给出需要对比的药物，和目标适应症，剩下的内容就全部交给药番茄好了，10分钟后回来下载你的临床对比报告。
想获得上述（美通立 VS 明复乐；依沃西单抗 VS K药）的完整报告，或使用药番茄临床对比，欢迎注册pharmato.cn，并联系助理。
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Research 19 June 2026
Article: 366
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Maternal B-vitamin status modifies the risk of congenital heart disease in offspring associated with prenatal persistent organic pollutants exposure
母体B族维生素状况会改变胎儿在宫内持续暴露于有机污染物时先天性心脏病的患病风险
Sainan LiHai LinLinlin Wang
Research 04 May 2026
Article: 365
Obesity-derived metabolites modulate anti-tumor immunity in the tumor microenvironment: from mechanisms to clinical applications
肥胖衍生的代谢产物在肿瘤微环境中调节抗肿瘤免疫：从机制到临床应用
Yihang CaiJunyi JinXiaoying Li
Review 06 May 2026
Article: 364
Part of 1 collection:Tumor microenvironment in cancer therapy
所属专题合集：癌症治疗中的肿瘤微环境
Rational use of expensive medicines in the Netherlands: strategies to improve effectiveness and reduce burden on patients and society – a narrative review
荷兰高价药品的合理使用：提高疗效、减轻患者和社会负担的策略——一项叙述性综述
Bart M.F. PenninxSander W. TasCarla E.M. Hollak
Review 30 April 2026
Article: 363
NMR-based serum metabolite and lipoprotein profiling for endometriosis across clinically relevant and physiological comparator settings: assessment of diagnostic utility and exploratory biological signals
基于核磁共振（NMR）的血清代谢物和脂蛋白谱分析在子宫内膜异位症的临床相关和生理对照情况中的应用：诊断效用的评估和探索性生物信号的发现
Sisi DengAndré KochChristoph Trautwein
Research 17 June 2026
Article: 362
Changes in olfactory function in children and adolescents with obesity following an inpatient weight loss program: a longitudinal study
住院减肥计划后肥胖儿童和青少年嗅觉功能的变化：一项纵向研究
Bea KlosHelene SauerIsabelle Mack
Research 17 June 2026
Article: 361
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减肥干预及其对健康的影响
The neuroimmune axis in breast cancer: from mechanistic insights to clinical applications
乳腺癌中的神经免疫轴：从机制研究到临床应用
Yimao WuKaiyu ZhangMeng-Yao Li
Review 30 April 2026
Article: 360
A biologically informed framework for instrument selection in dietary Mendelian randomization using chemosensory genetics
基于化学感觉遗传学的饮食孟德尔随机化工具选择生物学框架
Liang-Dar HwangCailu LinPaule V. Joseph
Research 01 June 2026
Article: 359
Efficacy and safety of cyclosporine plus luspatercept versus cyclosporine in newly diagnosed non-transfusion-dependent non-severe aplastic anemia: A prospective randomized trial
环孢素联合卢帕塞普特与单用环孢素治疗新发非输血依赖型非重型再生障碍性贫血的疗效和安全性：一项前瞻性随机试验
Zhuxin ZhangQinglin HuBing Han
Research 29 April 2026
Article: 358
Dietary intake and epigenetic aging in an African population: food groups, dietary patterns, and plant-based diets in the RODAM study
非洲人群的膳食摄入与表观遗传衰老：RODAM研究中的食物组、膳食模式与植物性饮食
Naomi C.S. AuwerdaMuhau. M. MungambaFelix P. Chilunga
Research 28 April 2026
Article: 357
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Mitoxantrone hydrochloride liposome (Lipo-MIT) combined with capecitabine in HER2-negative advanced breast cancer: a dose-escalation, phase I study
米托蒽醌盐酸盐脂质体（Lipo-MIT）联合卡培他滨治疗HER2阴性晚期乳腺癌：一项剂量递增Ⅰ期研究
Jiaxuan LiuMingxia JiangQiao Li
Research 28 April 2026
Article: 356
Familial healthy aging and longevity: the role of spouses
家族健康衰老与长寿：配偶的作用
Søren NetraAngéline GalvinKaare Christensen
Research 28 April 2026
Article: 355
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Peripheral blood biomarkers RCAN1, Clusterin, RAGE, and malondialdehyde for early diagnosis and progression of Alzheimer’s disease
外周血生物标志物RCAN1、Clusterin、RAGE和丙二醛用于阿尔茨海默病的早期诊断与进展监测
Aurora Román-DomínguezCristina Mas-BarguesJosé Viña
Research 27 April 2026
Article: 354
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Palliative care for the people without medical insurance in Germany: an empirical ethical approach
德国无医疗保险人群的姑息治疗：一种实证伦理方法
Matthias ZimmerAntonia Sahm
Research 11 June 2026
Article: 353
Part of 1 collection:Palliative care and medicine
所属专题合集：姑息治疗与姑息医学
Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study
妊娠期母体因素与微生物衍生的细胞外囊泡特征的相关性：一项临床队列研究
Jenni TurunenKaisu KyröTerhi Ruuska-Loewald
Research 28 May 2026
Article: 352
Prenatal computed tomography (CT) and risk of congenital heart disease and cerebral palsy: A nationwide mother–child paired cohort study
产前计算机断层扫描（CT）与先天性心脏病及脑瘫风险：一项全国性母子配对队列研究
Tae Wook KangJihye HeoDanbee Kang
Research 27 April 2026
Article: 351
Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease
治疗性TG2抑制可逆转乳糜泻的系统性多组学失调
Valeriia DotsenkoHana Hien Leon behalf of the CEC-3 Investigators
Research 24 April 2026
Article: 350
Adulthood stressful life events as predictors of incident cardiovascular disease: insights from two prospective cohorts
成年期应激性生活事件作为心血管疾病新发预测因子：来自两项前瞻性队列的见解
Shuang WuSiqi LyuGregory Y. H. Lip
Research 24 April 2026
Article: 349
Camrelizumab plus apatinib for immune checkpoint inhibitor-naive patients with metastatic clear cell renal cell carcinoma after first-line tyrosine kinase inhibitor treatment failure: a single-arm phase 2 trial
卡瑞利珠单抗联合阿帕替尼用于免疫检查点抑制剂初治转移性透明细胞肾细胞癌一线酪氨酸激酶抑制剂治疗失败后：一项单臂Ⅱ期试验
Xiuyu CaiXia ZhengPei Dong
Research 24 April 2026
Article: 348
Introducing the need for a consensus-based framework for protocol modifications to improve trial trustworthiness
提出建立基于共识的方案修改框架以提升临床试验可信度的必要性
Cora BurgwinkelManon GicquelClara Locher
Debate 24 April 2026
Article: 347
Modelling the epidemic dynamics of HPV among women in China and optimization of ongoing cervical cancer elimination strategies
中国女性人群HPV流行动力学建模及宫颈癌消除策略优化
Yuwei LiYi-Fan LinJianxin Zhen
Research 22 April 2026
Article: 346
Multiparameter concept-based interpretable model for early breast cancer diagnosis and structured reporting: a multi-center, multi-reader, radiologist-in-the-loop study
基于多参数概念的可解释模型用于早期乳腺癌诊断与结构化报告：一项多中心、多读者、放射科医师参与的研究
Jiao QuYang LiuSu Lui
Research 23 April 2026
Article: 345
Blood-based DNA methylation marker model for short-term and long-term lung cancer risk prediction
基于血液DNA甲基化标志物模型的肺癌短期与长期风险预测
Megha BhardwajYi-Qian SunHermann Brenner
Research 06 June 2026
Article: 344
Integrated serum proteomic and liver genomic analyses identify molecular signatures associated with metabolic dysfunction-associated steatotic liver disease: a multi-cohort study
整合血清蛋白质组学与肝脏基因组学分析鉴定与代谢功能障碍相关脂肪性肝病相关的分子特征：一项多队列研究
Jinjian XuWanglong GouYu-ming Chen
Research 17 April 2026
Article: 343
Predicting amyotrophic lateral sclerosis stage based on multi-parameter ultrasound: development and validation of an interpretable machine learning model
基于多参数超声预测肌萎缩侧索硬化症分期：可解释机器学习模型的构建与验证
Tianhua YangYing WangGaoyi Yang
Research 22 April 2026
Article: 342
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与更新
Duration of anti-seizure medicines started for acute symptomatic seizures due to acute meningitis: a systematic review and meta-analysis
急性脑膜炎所致急性症状性发作的抗癫痫药物起始疗程：一项系统综述与荟萃分析
Manya PrasadAmit KumarTarun Dua
Research 22 April 2026
Article: 341
Part of 1 collection:Acute meningitis: a collection of systematic reviews
所属专题合集：急性脑膜炎：系统综述集
Prenatal exposure to flood and risk of low birth weight: a multi-country study from 36 African countries
产前遭遇洪水与低出生体重风险：来自36个非洲国家的多国研究
Qian LiQian LiFengchao Liang
Research 21 April 2026
Article: 340
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
Sunshine duration and episodes of mental disorders and the inverse effect modification by ambient temperature
日照时长与精神障碍发作及环境温度的逆效应修饰
Lijun BaiJuan ChenShaowei Wu
Research 21 April 2026
Article: 339
The role of continuous glucose monitoring for diagnosis of gestational diabetes: exploring the potential
持续葡萄糖监测在妊娠糖尿病诊断中的作用：潜力探索
M. CrowleyC. NewmanF. P. Dunne
Review 21 April 2026
Article: 338
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠糖尿病的诊断与治疗
Pre-diagnostic biomarkers and risk of stress-related disorders: a cohort study based on electronic health records
应激相关障碍诊断前生物标志物与风险：一项基于电子健康记录的队列
Anna A. PeltolaEsha KhanJake Lin
Research 01 June 2026
Article: 337
Epigenome-wide analysis of DNA-methylation signatures following climate-related disasters
气候相关灾害后DNA甲基化信号的全表观基因组分析
Wenzhong HuangRongbin XuYuming Guo
Research 20 April 2026
Article: 336
Part of 1 collection:Climate change and human health
所属专题合集：其后变化与人类健康
Redeemed prescription medicines to measure quality of life of patients with long-term conditions: a national cross-sectional study
通过已兑换的处方药衡量慢性病患者生活质量：一项全国性横断面研究
Henrik Hedegaard Pliess LarsenVolkert SiersmaAnne Holm
Research 20 April 2026
Article: 335
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
属于专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Viral shedding dynamics in coxsackievirus A6 hand, foot, and mouth disease: a prospective, individual-level analysis
柯萨奇病毒A6型手足口病的病毒排毒动态：一项前瞻性个体水平分析
Jiale MengYue ChengLu Long
Research 18 April 2026
Article: 334
Mental health and wellbeing interventions for uniformed service personnel: a mixed methods systematic review
军警人员心理健康与福祉干预措施：一项混合方法系统综述
Jessica EatonHolly EllardAlan Simpson
Research 17 April 2026
Article: 333
WISE-Therapy (What’s Important: Schedule and Engage) and bouldering psychotherapy for depression: A randomized clinical trial
WISE-Therapy（智慧疗法）（重要之事：安排与参与）与抱石心理治疗用于抑郁症：一项随机临床试验
Johannes KornhuberPiotr LewczukKatharina Luttenberger
Research 27 May 2026
Article: 332
Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention
握力减弱与类风湿关节炎患者运动皮层萎缩相关：一项包含手部运动干预的横断面研究
Amanda L GustafssonRolf A HeckemannCaroline Wasén
Research 26 May 2026
Article: 331
Interpretable multimodal PET/CT-EHR fusion via mixture-of-experts for prognostic stratification in mantle cell lymphoma: a multicenter study
基于专家混合模型的可解释性多模态PET/CT-HER（电子健康记录）融合在套细胞淋巴瘤预后分层中的应用：一项多中心研究
Chong JiangZitong ZhangRong Tian
Research 16 April 2026
Article: 330
Non-invasive diagnosis strategy integrating PSMA PET/CT and mpMRI for patients with suspected prostate cancer: a multi-center study
整合PSMA PET/CT与多参数MRI的无创诊断策略用于疑似前列腺癌患者：一项多中心研究
Yuhang WangYongxiang TangYi Cai
Research 16 April 2026
Article: 329
Clinical benefit of tenecteplase despite failed recanalization in late-window ischemic stroke: a post hoc analysis of the TRACE-3 trial
晚期窗口缺血性卒中中即使再通失败，替奈普酶仍具临床获益：TRACE-3试验的事后分析
Zhengzhao LuZiran WangYongjun Wang
Research 16 April 2026
Article: 328
Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study
婴儿皮层下脑容量与母亲肥胖及糖尿病相关：一项大型多队列人类研究
Ann M. AlexJerod M. RasmussenENIGMA-ORIGINs working group
Research 16 April 2026
Article: 327
Cost-effectiveness of prehabilitation for elderly (pre-)frail patients prior to elective surgery compared to standard care - an economic evaluation from a societal perspective
择期手术前老年（衰弱前期/）衰弱患者预康复与标准护理的成本效益比较——一项基于社会视角的经济学评估
Tanja RombeyHelene EckhardtLukas Schöner
Research 21 May 2026
Article: 326
Frozen melanoma tissues yield extracellular vesicles with preserved diagnostic and immunogenic properties
冷冻黑色素瘤组织可获得具有保存完好的诊断和免疫特性的细胞外囊泡
Daniele D´ArrigoKyong-Su ParkRossella Crescitelli
Research 21 May 2026
Article: 325
Mechanisms underlying immunodynamics of layered defenses elicited by mRNA vaccination in children
儿童mRNA疫苗接种所引发的分层防御免疫动力学的潜在机制
Yiyu LiaoHoong Kai ChuaKeisuke Ejima
Research 15 April 2026
Article: 324
Epigenetic aging markers in the association between frailty and mortality among U.S. adults
美国成年人虚弱与死亡率相关性中的表观遗传衰老标志物
May A. BeydounNicole Noren HootenAlan B. Zonderman
Research 15 April 2026
Article: 323
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Evolution with age of the relationship between sex and post-COVID symptoms: a population-based cohort study
性别与新冠后遗症症状关系随年龄的演变：一项基于人群的队列研究
Anne PastorelloCécile Vuillermozfor the EpiCov study group
Research 14 April 2026
Article: 322
Bowel cancer care in individuals with an intellectual disability: a population-based cohort study of symptoms, diagnostic pathways, treatment and survival
智力障碍个体的肠癌护理：症状、诊断路径、治疗及生存的基于人群的队列研究
Oliver John KennedyUmesh ChauhanDarren Mark Ashcroft
Research 20 May 2026
Article: 321
Association of antiviral use for influenza among non-severe cases with subsequent hospitalization and mortality
非重症流感病例使用抗病毒药物与后续住院及死亡的关系
Taito KitanoShinya TsuzukiSayaka Yoshida
Research 06 April 2026
Article: 320
Social and digital engagement associated with reduced depressive symptoms in adults aged 50 and older: a multi-country cohort study
社交及数字互动与50岁及以上成年人抑郁症状减少的关系：一项多国队列研究
Yaping WangLiyuan TaoJue Liu
Research 07 April 2026
Article: 319
Fat-soluble vitamin deficiency in children with neurodevelopmental disorders: a cross-sectional study
神经发育障碍儿童脂溶性维生素缺乏：一项横断面研究
Jingjing RaoXiaomei WangChangzhen Li
Research 08 April 2026
Article: 318
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA)
巴尔的摩老龄化纵向研究（BLSA）中骨骼肌与心肌的纵向关联
Jie Jun WongFei GaoAngela S. Koh
Research 06 April 2026
Article: 317
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study
早期重复经颅磁刺激预防老年患者慢性术后疼痛：一项随机临床子研究
Wei-Wei ZhouZhi YangChao-Chao Zhong
Research 06 April 2026
Article: 316
Part of 1 collection:Neuromodulation in brain functional disorders
所属专题合集：脑功能障碍中的神经调控
Clinical epidemiology and risk prediction of unsuccessful treatment outcomes in pulmonary tuberculosis with diabetes mellitus
合并糖尿病的肺结核治疗失败结局的临床流行病学与风险预测
Ping LiFeilong LuJunjun Jiang
Research 25 March 2026
Article: 315
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与感染性疾病
Spatiotemporal patterns of climate-sensitive vector-borne diseases in Bangladesh: leveraging machine learning and spatial regression for intervention strategies
孟加拉国气候敏感型虫媒传染病的时空格局：利用机器学习与空间回归制定干预策略
Md. Siddikur RahmanMd. Abu Bokkor ShiddikArman Hossain Chowdhury
Research 13 April 2026
Article: 314
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
The association of pregnancy complications/risk factors with the development of cancer in women: an umbrella review
妊娠并发症/危险因素与女性癌症发生的关系：一项伞状综述
Jemma HealeyMegha SinghMairead Black
Research 13 April 2026
Article: 313
Synergistic effects of obesity and type 2 diabetes on adiposity-related cancer risk across age strata
肥胖与2型糖尿病对不同年龄层肥胖相关癌症风险的协同效应
Alex E. HenneyMegan HeagueDaniel J. Cuthbertson
Research 13 April 2026
Article: 312
Acute COVID-19 severity and impaired cognitive function up to 32months after diagnosis: an observational study
急性新冠严重程度与确诊后长达32个月的认知功能损害：一项观察性研究
Ingibjörg MagnúsdóttirAnders B. NygaardUnnur Anna Valdimarsdóttir
Research 11 April 2026
Article: 311
Maternal macronutrient intake and gestational diabetes: systematic review of prospective observational studies and dose-response meta-analyses
孕产妇宏量营养素摄入与妊娠期糖尿病：前瞻性观察研究的系统综述及剂量反应荟萃分析
Cameron D. YoungMichael G. GarrattAndrew N. Reynolds
Research 11 April 2026
Article: 310
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠期糖尿病的诊断与管理
Global, regional, and national burden of colorectal cancer attributable to central obesity: a population attributable fraction analysis
中心性肥胖所致结直肠癌的全球、区域及国家负担：人群归因分数分析
Daniele PiovaniGisella FiglioliStefanos Bonovas
Research 10 April 2026
Article: 309
Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study
评估首段尿液中DNA甲基化标志物及扩展型HPV基因分型在HPV阳性女性中检测高级别宫颈病变的价值：一项横断面研究
Mette TranbergSeverien Van KeerRenske Steenbergen
Research 10 April 2026
Article: 308
Targeted long-read genomic and epigenomic profiling enhances timely comprehensive variant discovery in hypotonia and muscle weakness
靶向长读长基因组与表观基因组测序提升低张力与肌无力的全面变异及时发现
Eman AbuijlanShruti SinhaAhmad Abou Tayoun
Research 08 April 2026
Article: 307
Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions
靶向肺疾病中的免疫衰老：机制洞察与临床干预
Yin ZhangXianzhe YuFengming Luo
Review 08 April 2026
Article: 306
Apolipoprotein C3 drives adverse cardiac remodeling in ischemic heart failure
载脂蛋白C3促进缺血性心力衰竭中的不良心脏重塑
Yufei HanYixue ZhaoXunde Xian
Research 09 April 2026
Article: 305
Part of 1 collection:Cardiac immunity and inflammation
所属专题合集：心脏免疫与炎症
Causal modeling of school aversion in psychiatrically referred adolescents: a DoWhy-based analysis
转诊精神病科的青少年厌学情绪的因果模型：基于DoWhy的分析
Mengmeng ZhangXin MaMeijuan Wang
Research 09 April 2026
Article: 304
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Aperiodic and periodic neural activity during sleep in autism spectrum disorders
自闭症谱系障碍睡眠中的非周期性和周期性神经活动
Noemi MazzoniEva-Maria KurzAndrea Caria
Research 18 March 2026
Article: 303
Part of 1 collection:Sleep and mental health
所属专题合集：睡眠与心理健康
Association and mediating pathways between intergenerational educational mobility and depressive symptoms: findings from high- and middle-income countries
代际教育流动性与抑郁症状之间的关联及中介路径：来自高收入和中等收入国家的发现
Yingchao ZengSimu HuangChihua Li
Research 02 April 2026
Article: 302
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Scoping review on the prioritisation of high-consequence infectious pathogens for research preparedness and response to health emergencies
关于优先研究高后果性感染病原体以应对突发卫生事件的研究准备与响应的范围综述
Nicolas PulikHolly SadlerAlice Norton
Research 01 April 2026
Article: 301
Serum uric acid levels among children and adolescents in China: percentile reference values and national prevalence estimates of hyperuricemia
中国儿童和青少年血清尿酸水平：高尿酸血症的百分位参考值和全国患病率估计
Qianrang ZhuXin’nan ZongMin Zhao
Research 31 March 2026
Article: 300
Waist circumference and grip strength and their joint relations to type 2 diabetes incidence in UK Biobank
腰围和握力及其与英国生物银行中2型糖尿病发病风险的联合关系
Johanna WirlerMichael J. SteinMichael F. Leitzmann
Research 07 May 2026
Article: 299
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Targeting cardiomyocyte-derived extracellular vesicle miR-574-5p protects against cognitive impairment induced by ischemia–reperfusion
靶向心肌细胞衍生的外泌体miR-574-5p可预防缺血再灌注引起的认知障碍
Erya ChenXiaoyu ZhuChan Chen
Research 19 March 2026
Article: 298
Motor-related reorganization in left inferior frontal gyrus after subcortical stroke: neurochemical basis and response to targeted neuromodulation
皮层下卒中后左侧额下回的运动相关重组：神经化学基础及靶向神经调控的反应
Wenjun HongYaxi WangZhiyong Zhao
Research 27 March 2026
Article: 297
Part of 1 collection:Neuromodulation in brain functional disorders
所属专题合集：脑功能疾病中的神经调控
Association between ambient temperature and childhood vaccination coverage in low- and middle-income countries
中低收入国家环境温度与儿童疫苗接种覆盖率之间的关联
Hongqiu ZhengYixiang ZhuZhiyuan Hou
Research 11 March 2026
Article: 296
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss
肌萎缩侧索硬化症奖赏回路白质改变：基于纤维束的食欲减退研究
Jeryn ChangHarry LipscombeThomas B. Shaw
Research 27 March 2026
Article: 295
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
The adverse effects associated with tirzepatide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis
替西帕肽在心血管事件风险增加患者中的不良反应：一项系统综述与荟萃分析及试验序贯分析
Christina Dam Bjerregaard SillassenPascal FaltermeierJanus Christian Jakobsen
Research 27 March 2026
Article: 294
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减肥干预措施及其健康影响
Age-related genomic characterization and therapeutic targets in Chinese breast cancer: insights from prospective targeted sequencing and clinical data analysis
中国乳腺癌年龄相关基因组特征及治疗靶点：前瞻性靶向测序与临床数据分析的见解
Xin-Yi SuiXiao-Qing SongLei Fan
Research 27 March 2026
Article: 293
Impact of the family cohesion-centered frailty intervention on older gastric cancer patients: a non-randomized controlled trial
以家庭凝聚力为中心的衰弱干预对老年胃癌患者的影响：一项非随机对照试验
Yinning GuoYimeng ChenQin Xu
Research 27 March 2026
Article: 292
Part of 1 collection:Clinical trials for gastrointestinal cancer
所属专题合集：胃肠道癌症临床试验
Perceptions of HPV vaccination: a qualitative study with adolescents, parents, school staff, and pharmacists
对HPV疫苗接种的看法：一项针对青少年、家长、学校工作人员和药剂师的定性研究
Laurène HoutinLucia RomoClémence Brun
Research 26 March 2026
Article: 291
Risk classification of internet gaming disorder based on neurobiological subtyping from impulsivity-linked resting-state functional connectivity: a longitudinal design study
基于冲动性相关静息态功能连接神经生物学亚型的网络游戏障碍风险分类：一项纵向设计研究
Xinwen WenJiahao ZhaoKai Yuan
Research 26 March 2026
Article: 290
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Trainee-delivered school-based intervention with guided narrative writing for adolescent anxiety and depression: a cluster randomized controlled trial
由受训者实施的、基于学校的、以引导性叙事写作为干预手段的青少年焦虑和抑郁干预：一项整群随机对照试验
Yixuan WangMuyang LiYinyin Zang
Research 26 March 2026
Article: 289
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Nourishing future generations: the critical role of healthy school lunches and strategic food procurement
滋养未来一代：健康学校午餐和战略性食品采购的关键作用
Aurora Perez-CornagoCarmen Piernas
Comment 05 May 2026
Article: 288
Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury
多组学分析揭示人类骨骼肌损伤后肌无力的性别特异性病因
Alexander R. KeebleAllison M. OwenChristopher S. Fry
Research 26 March 2026
Article: 287
Public health impact of catch-up vaccination or additional booster doses with pre-erythrocytic malaria vaccine R21/Matrix-M: a modelling study
使用红细胞前期疟疾疫苗R21/Matrix-M进行追赶接种或额外加强接种的公共卫生影响：一项建模研究
Kelly McCainHillary M. TopazianAzra C. Ghani
Research 25 March 2026
Article: 286
A digital-health multidomain lifestyle management framework and its associations with cardiometabolic health: a real-world observational study
数字健康多领域生活方式管理框架及其与心脏代谢健康的关联：一项现实观察性研究
Han XiaoKexin DingDafang Chen
Research 25 March 2026
Article: 285
Bilateral sequential accelerated theta-burst stimulation for treatment-resistant depression: an open-label randomized controlled trial
双侧序贯加速θ波爆发刺激治疗难治性抑郁症：一项开放标签随机对照试验
Xingxing LiEnze TangDongsheng Zhou
Research 25 March 2026
Article: 284
Part of 1 collection:Neuromodulation in brain functional disorders
所属专题合集：脑功能疾病中的神经调控
Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders
SPG7和AFG3L2基因突变双基因遗传导致运动神经元和小脑疾病
Mehrdad A. EstiarEric YuZiv Gan-Or
Research 24 March 2026
Article: 283
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新颖动态
Social isolation and 59 common health conditions: insights from observational and genetics analyses
社交孤立与59种常见健康状况：观察性研究与遗传学分析的见解
Sizhi AiQiqi WuYannis Yan Liang
Research 23 March 2026
Article: 282
Clustering depression subgroups based on dorsolateral prefrontal-subgenual anterior cingulate cortex peak functional connectivity reveals different symptom profiles and TMS treatment outcomes
基于背外侧前额叶-膝下前扣带回皮层峰值功能连接性的抑郁亚组聚类分析揭示了不同的症状特征和经颅磁刺激（TMS）治疗结果
Gai KongSirui WangYingying Tang
Research 23 March 2026
Article: 281
Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours
人类遗传学有力证据支持成纤维细胞生长因子21（FGF21）对减少饮酒行为的因果效应
Héléne T. CronjéSile HuDipender Gill
Research 23 March 2026
Article: 280
Artificial intelligence-based prediction of fetal hypoxia: a multicenter model development and nationwide AI-human comparison
基于人工智能的胎儿缺氧预测：多中心模型开发及全国范围的人工智能与人类对比
Suiwen LinXiaodan DiBin Liu
Research 21 March 2026
Article: 279
Efficacy and long-term engagement of a WeChat-integrated modality versus a traditional quitline on smoking cessation in China: a randomised controlled trial
微信整合模式与传统戒烟热线在中国戒烟中的疗效及长期参与度：一项随机对照试验
Shuilian ChuDi ZhangLirong Liang
Research 21 March 2026
Article: 278
A culturally-safe primary care intervention for migrant/refugee women suffering domestic violence and abuse: HARMONY—a pragmatic cluster randomised controlled trial
针对遭受家庭暴力和虐待的移民/难民妇女的文化安全初级护理干预措施：HARMONY——一项实用性整群随机对照试验
Angela J. TaftFelicity YoungGene Feder
Research 21 March 2026
Article: 277
Development, integration, retention, and career progression of physician associates/assistants in UK NHS hospitals and clinical teams: a multiple-case qualitative study
英国国家医疗服务体系（NHS）医院及临床团队中医师助理/协理医师的发展、整合、留任及职业晋升：一项多案例定性研究
Yingxi ZhaoRhys SwainstonThe ROADMAP-PA collaborator group
Research 20 April 2026
Article: 276
Compound climate extreme events and associated health impacts: a scoping review
复合气候极端事件及其相关健康影响：一项范围性综述
Shifali MathewsCaitlin WalkerJaime Madrigano
Research 20 March 2026
Article: 275
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
Smoking history, eligibility for lung cancer screening and risk of death by lung cancer or other causes -- a longitudinal, time-variable analysis of the EPIC-Heidelberg cohort
吸烟史、肺癌筛查资格以及死于肺癌或其他原因的风险——对EPIC-海德堡队列的纵向、时变分析
Yue ChenSrimanti DuttaRudolf Kaaks
Research 28 April 2026
Article: 274
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Cortical functional hierarchy disruption following subcortical stroke
皮质功能层级在皮层下卒中后的破坏
Ke WuGang LiuGaolang Gong
Research 19 March 2026
Article: 273
Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization
利用孟德尔随机化方法表征遗传易感性对自身免疫性疾病患者妊娠结局的影响
Elisabeth AitonNancy S. McBrideMaria Carolina Borges
Research 19 March 2026
Article: 272
Dystrophin-gene mutation location influences severity of electroretinogram defects in mouse models of Duchenne muscular dystrophy
杜氏肌营养不良症小鼠模型中，肌营养不良蛋白基因突变位置对视网膜电图缺陷严重程度的影响
André Maurício Passos LiberMirella BarboniCyrille Vaillend
Research 25 April 2026
Article: 271
Personalizing the treatment of head and neck cancer in vitro: The 3D-OTC model
体外个性化治疗头颈部肿瘤：三维器官芯片（3D-OTC）模型
Fabian StögbauerTobias WeiserBarbara Wollenberg
Research 25 April 2026
Article: 270
Part of 1 collection:Organoids: connecting molecular insights and clinical practice
所属专题合集：类器官：连接分子见解与临床实践
Risk factor profiles for infections in individuals with type 2 diabetes: a prospective cohort study
2型糖尿病患者感染的风险因素特征：一项前瞻性队列研究
Han-Cheng YuJi-Juan ZhangYun-Fei Liao
Research 18 March 2026
Article: 269
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与感染性疾病
Cause-specific years of life lost attributable to non-optimal body mass index by county, sex, race, and ethnicity in the USA, 2000–2019: a systematic analysis of health disparities
2000-2019年美国按县、性别、种族和民族划分的非最佳体重指数导致的特定原因寿命损失年数：一项关于健康差异的系统分析
GBD US Health Disparities CollaboratorsFarah MouhannaLaura Dwyer-Lindgren
Research 18 March 2026
Article: 268
Global and regional prevalence, burden, and risk factors for MASLD in children and adolescents aged 5 to 24years: a systematic review, meta-analysis, and modeling study
全球和区域5至24岁儿童和青少年代谢相关脂肪性肝病（MASLD）的患病率、负担及风险因素：一项系统综述、荟萃分析和建模研究
Yunfei LiuShan CaiSusan M. Sawyer
Research 18 March 2026
Article: 267
Relative leukocyte telomere length and the risk of lung cancer progression in individuals with pulmonary nodules
相对白细胞端粒长度与肺结节患者肺癌进展风险的关系
Yuanyuan WuDong SunFeifei Cheng
Research 18 March 2026
Article: 266
Effects of Tai Chi combined with transcranial direct current stimulation on pain in knee osteoarthritis: a randomized controlled neuroimaging trial
太极拳结合经颅直流电刺激对膝骨关节炎疼痛的影响：一项随机对照神经影像学试验
Xuefeng LiuTong TangJing Tao
Research 17 March 2026
Article: 265
DNA hypermethylation of choline kinases drives blockage of choline-phosphatidylcholine biosynthesis: lipidomic biomarkers and epigenetic insights of hepatic steatosis induced by arsenic
胆碱激酶DNA高甲基化驱动胆碱-磷脂酰胆碱生物合成受阻：砷诱导的肝脂肪变性的脂质组学生物标志物及表观遗传学见解
Qiwen FuQi WangLu Ma
Research 17 March 2026
Article: 264
Dynamics of Mpox epidemics by the interplay of COVID-19 pandemic in Africa
非洲猴痘（Mpox）流行与新冠肺炎（COVID-19）大流行相互作用下的猴痘流行病学动态
Oyewole K. OyedeleNifarta P. AndrewAlash’le Abimiku
Research 17 March 2026
Article: 263
Part of 1 collection:Mpox: Epidemiology, prevention, and treatment
所属专题合集：猴痘：流行病学、预防和治疗
SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection
SPP1高表达成纤维性巨噬细胞介导保护性纤维化重塑并促进高血压相关主动脉夹层的血管稳定性
Shuai ZhaoXiumeng HuaJiangping Song
Research 16 March 2026
Article: 262
Longitudinal associations between body fat mass and cardiovascular outcomes among Chinese children: mediation by cardiometabolic risk factors
中国儿童身体脂肪量与心血管结局之间的纵向关联：通过心脏代谢风险因素的中介作用
Hui YangQin LiuBo Xi
Research 16 March 2026
Article: 261
The timing of the commencement of pulmonary rehabilitation in hospitalized patients with acute exacerbation of COPD: a systematic review and network meta-analysis
住院慢性阻塞性肺疾病急性加重患者开始肺康复治疗的时机：一项系统综述和网络荟萃分析
Peilin JiaHailong ZhangLongyu Wang
Research 16 March 2026
Article: 260
Correction: Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study
更正：膀胱癌流行病学和营养决定因素（BLEND）国际研究中蔬菜摄入量与膀胱癌风险的关系
Evan Yi-Wen YuAnke WesseliusMaurice P. Zeegers
Correction 22 April 2026
Article: 259
Comparative efficacy of neoadjuvant short-course versus long-course radiotherapy-based regimens with or without immunotherapy for locally advanced pMMR rectal cancer: a systematic review and network meta-analysis
基于放疗的新辅助短疗程与长疗程治疗方案（联合或不联合免疫治疗）对局部晚期错配修复功能正常（pMMR）型直肠癌的疗效比较：一项系统综述与网状荟萃分析
Liqing LiXiaoyao MengTingshi Su
Research 14 March 2026
Article: 258
Association between bariatric surgery and long-term ability to perform household tasks in the Swedish Obese Subjects study: a controlled prospective cohort study
瑞典肥胖受试者研究：减肥手术与长期从事家务能力之间的关联——一项对照前瞻性队列研究
Petra BrembeckJohanna C. Andersson-AssarssonPer-Arne Svensson
Research 18 April 2026
Article: 257
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减重干预措施及其健康影响
The role of male foetal sex on maternal and neonatal outcomes in pregnancies complicated by gestational diabetes—secondary analysis of a randomised placebo controlled clinical trial of metformin in gestational diabetes (EMERGE)
男性胎儿性别对妊娠期糖尿病合并妊娠的母婴预后的影响——妊娠期糖尿病二甲双胍随机对照安慰剂临床试验（EMERGE）的二次分析
Christine NewmanAlberto Alvarez-IglesiasFidelma Dunne
Research 12 March 2026
Article: 256
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠期糖尿病的诊断与管理
Downregulated lysyl oxidase in plasma extracellular vesicles: a biomarker linked to brain metastasis risk in lung adenocarcinoma
血浆细胞外囊泡中赖氨酰氧化酶表达下调：与肺腺癌脑转移风险相关的生物标志物
Jing LiYu PeiYi Liu
Research 12 March 2026
Article: 255
The influence of age-dependent susceptibility on RSV transmission dynamics and immunisation population-level impact
年龄依赖性易感性对呼吸道合胞病毒（RSV）传播动力学及免疫接种人群层面影响的研究
Chenkai ZhaoYuhe ZhangHarish Nair
Research 11 March 2026
Article: 254
A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress
一株人源拟杆菌属菌株可减轻社会挫败诱导应激大鼠模型的抑郁样行为
Marisol I. DothardMariaelena CaboniPhilip Strandwitz
Research 10 March 2026
Article: 253
Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing
童年和成年期的不良事件均与衰老的分子、临床和功能标志物相关
Monica AasThole H HoppenJulian Mutz
Research 28 April 2026
Article: 252
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Genetic predisposition to high BMI, ultra-processed food consumptions in childhood, and adiposity in young adulthood: a 17-year prospective cohort study of 3061 individuals
高BMI遗传易感性、儿童期超加工食品摄入与成年早期肥胖：一项对3061例个体进行的为期17年的前瞻性队列研究
Ziyi ZhouQiaosen ChenFrederick K. Ho
Research 16 April 2026
Article: 251
Enhanced predictive performance of artificial intelligence in individualized ovarian stimulation of in vitro fertilization: a retrospective cohort study
人工智能在体外受精个体化卵巢刺激中的预测性能提升：一项回顾性队列研究
Guiquan WangMinyue TangYimin Zhu
Research 10 March 2026
Article: 250
PCDSOS: a novel clinical predictive tool for screening primary ciliary dyskinesia in adult bronchiectasis patients—a multicenter derivation and external validation study
PCDSOS：一种用于筛查成人支气管扩张症患者原发性纤毛运动障碍的新型临床预测工具——一项多中心推导及外部验证研究
Wangji ZhouLin WangXinlun Tian
Research 10 March 2026
Article: 249
Detection rate and mutational landscape in extracranial arteriovenous malformations: a cohort study
颅外动静脉畸形的检出率及突变谱：一项队列研究
Vanessa F. SchmidtDenny Schanzefor the APOLLON Investigators
Research 16 April 2026
Article: 248
Kinetics of antibodies and risk of respiratory syncytial virus infection: a longitudinal cohort in Taizhou City, eastern China
抗体动力学与呼吸道合胞病毒感染风险：中国东部台州市的一项纵向队列研究
Qiang WangDavid HodgsonWeibing Wang
Research 09 March 2026
Article: 247
Cell therapy strategies for organ regeneration
器官再生的细胞治疗策略
L. PapamichailL. J. W. van der LaanM. J. Hoogduijn
Review 25 February 2026
Article: 246
Transcutaneous spinal cord stimulation combined with robot-assisted gait training to improve mobility and balance in spinal cord injury: intramuscular electromyography as a biomarker for functional recovery
经皮脊髓电刺激联合机器人辅助步态训练改善脊髓损伤患者的行动能力和平衡能力：肌内肌电图作为功能恢复的生物标志物
Abdul RashadHe XijingMuhammad Asif
Registered Report 09 March 2026
Article: 245
Neoadjuvant camrelizumab combined with radiotherapy as a chemotherapy-sparing approach for resectable locally advanced esophageal squamous cell carcinoma: a phase II clinical trial (ESOCORT-NIRT)
新辅助卡瑞利珠单抗联合放疗作为可切除局部晚期食管鳞癌的免化疗方案：一项II期临床试验（ESOCORT-NIRT）
Maohui ChenYizhou HuangBin Zheng
Research 09 March 2026
Article: 244
FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy
FLASH放疗在保持抗肿瘤疗效的同时维持全身及组织稳态
Giulia FuriniEduarda Mota da SilvaMargherita Maffei
Research 26 February 2026
Article: 243
fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial
功能磁共振成像引导的V1区靶向重复经颅磁刺激改善青少年及青年双相情感障碍患者的抑郁症状：一项双盲随机对照试验
Xudong ZhaoHetong ZhouMinmin Wang
Research 07 March 2026
Article: 242
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童及青少年精神病学
Impairment of brain short association fibers across clinical stages in amyotrophic lateral sclerosis: a new biomarker mirroring disease progression
肌萎缩侧索硬化症临床各阶段脑短联结纤维受损情况：一种反映疾病进展的新型生物标志物
Nao-Xin HuangZi-Wei CaiHua-Jun Chen
Research 06 March 2026
Article: 241
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Social frailty and the risk of progression from health to physical, psychological, and cognitive multimorbidity: a prospective multi-cohort study
社会脆弱性与从健康状态进展至身体、心理及认知多病共存状态的风险：一项前瞻性多队列研究
Yaguan ZhouHtet Lin HtunYi Guo
Research 06 March 2026
Article: 240
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用
Association between early life constituent-specific PM2.5 exposure and child development and the moderating role of greenness: a nationwide study in China
中国全国范围内早期生命特定成分PM2.5暴露与儿童发育的关联及绿地调节作用的研究
Ruili LiXiaoguo ZhengXiaoning Lei
Research 06 March 2026
Article: 239
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童及青少年精神病学
Intravenous thrombolysis versus standard medical therapy in minor stroke patients with large vessel severe stenosis or occlusion: a systematic review and meta-analysis
静脉溶栓与标准药物治疗轻型卒中合并大血管重度狭窄或闭塞患者的系统综述与荟萃分析
Tianhao ZhangLin TongZhigang Liang
Research 06 March 2026
Article: 238
Long-term risk of offspring type 1 and type 2 diabetes following maternal gestational diabetes mellitus: a nationwide birth cohort study with 10-year follow-up
母亲妊娠期糖尿病后子女患1型和2型糖尿病的长期风险：一项为期10年随访的全国出生队列研究
Joon Ho MoonHan Na JungSung Hee Choi
Research 06 March 2026
Article: 237
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠期糖尿病的诊断与治疗
Parental income in childhood and health outcomes across age groups: a register-based study from Norway
童年期父母收入与各年龄段健康结局：一项基于挪威登记数据的研究
Bjørn-Atle RemeHans Fredrik SundeJonathan Wörn
Research 06 March 2026
Article: 236
AI-based quality control was associated with improved fetal ultrasound image quality in low-resource settings: a real-world multicenter study from West China
基于人工智能的质量控制可改善低资源环境下胎儿超声图像质量：一项来自中国西部的现实多中心研究
Jianxin ZhaoYao TangYong Huang
Research 06 March 2026
Article: 235
Reply to: Intraoperative use of sodium oxybate to prevent post-operative delirium in older patients undergoing major orthopedic surgery
回复：术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄
Meiying CuiHang XuePing Zhao
Matters Arising 13 April 2026
Article: 234
Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis
无假设的循环代谢组学评估为肌萎缩侧索硬化症中能量底物可用性的细胞特异性作用提供见解
Elham AlhathliJohnathan Cooper-KnockPamela J. Shaw
Research 06 March 2026
Article: 233
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Intraoperative use of sodium oxybate to prevent postoperative delirium in older patients undergoing major orthopedic surgery
术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄
Fu-Shan XueDan-Feng WangXiao-Chun Zheng
Matters Arising 13 April 2026
Article: 232
Statin therapy and stroke risk in patients with hypercholesterolaemia: a population-based longitudinal study using electronic health records in South London
他汀类药物治疗与高胆固醇血症患者卒中风险：一项基于南伦敦电子健康记录的纵向人群研究
Marc DelordAbdel Douiri
Research 05 March 2026
Article: 231
Thermal ablation versus hepatectomy for solitary colorectal liver metastases up to 5 cm: a multicenter target trial emulation on safety, efficacy, and cost-effectiveness
热消融与肝切除术治疗直径达5厘米的孤立性结直肠癌肝转移：一项关于安全性、疗效及成本效益的多中心目标试验模拟研究
Jianming LiLu LiPing Liang
Research 05 March 2026
Article: 230
Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetes
为何高胰岛素血症不利于减重：来自1型糖尿病的见解
Stephan MartinKerstin KempfHubert Kolb
Debate 10 April 2026
Article: 229
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减重干预措施及其健康影响
Interventions to prevent and treat multiple long-term conditions and their consequences across the life course: concepts and definitions
预防和治疗多种长期疾病及其在生命周期中后果的干预措施：概念与定义
Miles D. WithamGuruprasad P. AithalThe Multiple Long-Term Conditions Cross-NIHR Collaboration Interventions and Prevention Workstream
Forum 10 April 2026
Article: 228
Effectiveness of nirmatrelvir/ritonavir and molnupiravir on post-COVID diabetes risk among an older adult cohort: a target trial emulation study
奈玛特韦/利托那韦和莫努匹韦对老年人群新冠后糖尿病风险的影响：一项目标试验模拟研究
Zihao GuoYuchen WeiKa Chun Chong
Research 17 March 2026
Article: 227
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与传染病
Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS
瑞典基于人群的队列研究AMORIS中铁缺乏与痴呆风险的证据
Mozhu DingAlexandra WennbergKarin Modig
Research 08 April 2026
Article: 226
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Effects of ultrasound-guided stellate ganglion block in poststroke bulbar palsy: a double-blind placebo-controlled trial
超声引导下星状神经节阻滞对脑卒中后球麻痹的影响：一项双盲安慰剂对照试验
Hongji ZengWeihong ZhangXi Zeng
Research 04 March 2026
Article: 225
Dual-utility ctDNA in diffuse large B-cell lymphoma: integrated genotyping unveils minimal residual disease dynamics and subtype-specific clonal evolution
双用途循环肿瘤DNA在弥漫性大B细胞淋巴瘤中的应用：整合基因分型揭示微小残留病灶动态变化及亚型特异性克隆演变
Jin-Hua LiangYi-Fan WuWei Xu
Research 04 March 2026
Article: 224
Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2pathogenic variant carriers: a prospective cohort study
BRCA1和BRCA2致病性变异携带者患非乳腺、非卵巢癌的风险：一项前瞻性队列研究
Ruotong YangRobert J. MacInnisShuai Li
Research 04 March 2026
Article: 223
Cardiovascular outcomes of intensive blood pressure control in patients with and without metabolic dysfunction-associated fatty liver disease: post hoc analysis of the CRHCP trial
在伴有和不伴有代谢功能障碍相关脂肪性肝病的患者中，强化血压控制的心血管预后：CRHCP试验的事后分析
Songyue LiuYangzhi YinXiaofan Guo
Research 04 March 2026
Article: 222
The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations
慢性阻塞性肺疾病和吸入性糖皮质激素在心血管-肾脏-代谢人群主要不良心血管事件中的作用
Anne E. IoannidesEmily L. GraulJennifer K. Quint
Research 04 March 2026
Article: 221
Ethnic differences in the burden of cardiovascular disease risk factors among adult residents of London: the TOGETHER study
伦敦成年居民心血管疾病风险因素负担的种族差异：TOGETHER研究
Fotios BarkasMalo DirouKausik K. Ray
Research 03 March 2026
Article: 220
Development of a novel prognostic assessment tool for recurrent respiratory papillomatosis
复发性呼吸道乳头瘤病新型预后评估工具的开发
Satoshi YamadaTaro IkegamiKiyoshi Misawa
Research 16 April 2026
Article: 219
Response to: Matters Arising in relation to “Evaluating agreement between individual nutrition randomised controlled trials and cohort studies – a meta-epidemiological study”
针对“评估个体营养随机对照试验与队列研究之间的一致性——一项元流行病学研究”的相关问题探讨
Julia StadelmaierGina BantleLukas Schwingshackl
Matters Arising 09 April 2026
Article: 218
Concordance between nutritional cohorts and randomized trials: biological confirmation or statistical consequence? A re-analysis of Stadelmaier et al.
营养队列研究与随机试验之间的一致性：生物学证实还是统计学结果？对Stadelmaier等人的研究再分析
Matthew CalkinsIsaac NúñezAdrian Soto-Mota
Matters Arising 09 April 2026
Article: 217
Multimorbidity patterns and 15-year trajectories of physical performance: a population-based study
多病共存模式与15年身体机能变化轨迹：一项基于人群的研究
Francesco PalmeseDavide Liborio VetranoFederico Triolo
Research 25 March 2026
Article: 216
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
The need for clinical studies assessing whether weight loss improves functional outcome after stroke in diabetes
评估减肥是否改善糖尿病患者中风后功能预后的临床研究需求
Ellen VercalsterenMichael V. MazyaCesare Patrone
Debate 24 March 2026
Article: 215
Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice
靶向STE20型激酶MST3可改善小鼠代谢功能障碍相关脂肪性肝炎，且不影响肝细胞癌的发展
Jingjing ZhangXiangdong GongyeMargit Mahlapuu
Research 24 March 2026
Article: 214
Multimorbidity patterns and the subsequent risk of albuminuria: findings from the Stockholm Creatinine Measurements (SCREAM) project
多病共存模式与后续白蛋白尿风险：来自斯德哥尔摩肌酐测量（SCREAM）项目的研究结果
Giorgi BeridzePatrick B. MarkJuan-Jesus Carrero
Research 24 March 2026
Article: 213
Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma
胶质母细胞瘤神经元微环境中髓系来源的免疫抑制对嵌合抗原受体T细胞的影响
Junyi ZhangJasmin von EhrYahaya A. Yabo
Research 13 March 2026
Article: 212
Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization
基因预测的白细胞介素-6和肿瘤坏死因子信号通路与结直肠癌患者死亡率之间的关联：一项双样本孟德尔随机化研究
Martina BoukaKatharina NimptschTobias Pischon
Research 06 March 2026
Article: 211
Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS
血管生成素样系统紊乱将肌萎缩侧索硬化症中的脂质稳态与下丘脑功能障碍关联起来
Sruthi Sankari KrishnamurthyAdriana Zardini BuzattoFrancesco Roselli
Research 03 March 2026
Article: 210
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Day+30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML
移植后第30天通过高灵敏度PCR-NGS检测微小残留FLT3-ITD可预测急性髓系白血病（AML）复发风险并指导移植后维持治疗
Shan JiangDan FengErlie Jiang
Research 03 March 2026
Article: 209
Early childhood weight gain and alanine aminotransferase at age 8: an adjunct study of the Japan Environment and Children’s Study
幼儿期体重增长与8岁时丙氨酸氨基转移酶水平：日本环境与儿童研究的一项辅助研究
Naw Awn J-PKeiko YamasakiNarufumi Suganuma
Research 03 March 2026
Article: 208
Anti-CD19 chimeric antigen receptor T-cell therapy for relapsed or refractory Philadelphia chromosome-positive B cell acute lymphoblastic leukemia: a multicenter retrospective study
抗CD19嵌合抗原受体T细胞疗法治疗复发或难治性费城染色体阳性B细胞急性淋巴细胞白血病：一项多中心回顾性研究
Jinglei YuFengmei SongGuoqing Wei
Research 03 March 2026
Article: 207
Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics
通过单细胞和空间转录组学鉴定人类卵巢皮质中的冷敏感生态位及可靶向的FOS/AP-1程序
Fanghao GuoDi SunWen Li
Research 03 March 2026
Article: 206
Neoadjuvant camrelizumab combined with metronomic chemotherapy in patients with advanced esophageal squamous cell carcinoma: a pilot randomized phase 2 trial
卡瑞利珠单抗联合节拍化疗新辅助治疗晚期食管鳞状细胞癌：一项随机2期初步试验
Zhiming ChenWenshuai LiJie Liu
Research 03 March 2026
Article: 205
Part of 1 collection:Clinical trials for gastrointestinal cancer
所属专题合集：胃肠道癌症临床试验
Vericiguat for endothelial dysfunction and CRT response in non-responders: the VERCET prospective observational study
维利西呱治疗无反应者的内皮功能障碍和心脏再同步化治疗（CRT）反应：VERCET前瞻性观察研究
Celestino SarduLudovica Vittoria MarfellaRaffaele Marfella
Research 03 March 2026
Article: 204
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病和心律失常
Assessment of antibody responses to Anopheles SG6-P1 and Aedes N-term 34kDa salivary peptides: a randomised human-challenge trial of controlled exposures to vector bites
评估针对按蚊SG6-P1和伊蚊N端34 kDa唾液肽的抗体反应：一项对媒介叮咬进行可控暴露的随机人体挑战试验
Victor ChaumeauEllen A. KearneyFreya J. I. Fowkes
Research 02 March 2026
Article: 203
Is random biopsy necessary for normal esophageal mucosa during chromoendoscopy? Evidence from a population-based cohort study
在色素内镜检查过程中，对于正常食管黏膜是否有必要进行随机活检？一项基于人群的队列研究证据
Wenlei YangMengfei LiuYang Ke
Research 02 March 2026
Article: 202
Sinusoidal cell–derived biomarker scores predict diagnosis and prognosis in chronic liver disease
窦状隙细胞来源的生物标志物评分可预测慢性肝病的诊断和预后
Sergi Guixé-MuntetAnabel Fernández-IglesiasJordi Gracia-Sancho
Research 28 February 2026
Article: 201
Anticholinergic drug burden and incident cardiovascular events: a population-based study
抗胆碱能药物负担与新发心血管事件：一项基于人群的研究
Nanbo ZhuMaria EriksdotterHong Xu
Research 28 February 2026
Article: 200
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study
从儿童期到成年期体重指数（BMI）变化对亚临床心血管结局影响的敏感期：一项为期36年的前瞻性队列研究
Hui YangTongshuai GuoJianjun Mu
Research 27 February 2026
Article: 199
Feasibility and preliminary efficacy of an art-making program to manage fear of cancer recurrence (AM-I-FCR) in lung cancer patients: a randomized controlled pilot study
艺术创作项目（AM-I-FCR）管理肺癌患者对癌症复发恐惧的可行性与初步疗效：一项随机对照试点研究
Jialing LinZhixuan KangFeifei Huang
Research 27 February 2026
Article: 198
Unveiling disparities in lung cancer care: a joint spatio-temporal analysis of multidisciplinary meeting presentation, supportive care screening, and diagnostic timeliness in Victoria
揭示肺癌诊疗差异：维多利亚州多学科会诊展示、支持性护理筛查及诊断及时性的联合时空分析
Getayeneh Antehunegn TesemaRob G. StirlingArul Earnest
Research 27 February 2026
Article: 197
Transcriptome-based high-frequency recurrence index predicts frequent recurrence in non-muscle-invasive bladder cancer after Bacillus Calmette-Guérin therapy
基于转录组的高频复发指数可预测卡介苗治疗后非肌层浸润性膀胱癌的频繁复发情况
Seung-Woo BaekYoung Joon ByunSeok Joong Yun
Research 27 February 2026
Article: 196
Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study
出生体重对健康老龄化的终身影响及后续途径：一项孟德尔随机化研究
Lijie KongChun DouTiange Wang
Research 25 February 2026
Article: 195
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Routine inflammatory indices modify clonal hematopoiesis-related prognostic risk in patients undergoing percutaneous coronary intervention: a real-world cohort study
常规炎症指标改变接受经皮冠状动脉介入治疗患者的克隆性造血相关预后风险：一项现实队列研究
Xuxiang ShenYing SongXiangfeng Lu
Research 25 February 2026
Article: 194
Health experiences and outcomes of autistic and non-autistic adults with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder
自闭症和非自闭症成年孤独症患者及非孤独症患者中患有高迁移率埃勒斯-丹洛斯综合征和高迁移率谱系障碍者的健康体验和预后
Catherine J. CromptonThemis N. EfthimiouKathryn M. Berg
Research 25 February 2026
Article: 193
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Effects of non-pharmacological interventions on sleep quality in older adults: a systematic review and network meta-analysis of randomized controlled trials
非药物干预措施对老年人睡眠质量影响：基于随机对照试验的系统综述和网络荟萃分析
Jia SongHeng DongShangfeng Tang
Research 25 February 2026
Article: 192
Cortical excitability mapping stratifies neurobiological subtypes of schizophrenia with genetic and molecular signatures
皮质兴奋性映射对具有遗传和分子特征的精神分裂症神经生物学亚型进行分层
Sixuan GuoYu ZhaoQiyong Gong
Research 25 February 2026
Article: 191
Minimum 18-week chemotherapy improves survival in locally advanced rectal cancer after neoadjuvant radiotherapy: a post hoc analysis of the STELLAR trial
新辅助放疗后局部晚期直肠癌患者接受至少18周化疗可改善生存率：STELLAR试验的事后分析
Tongzhen XuHuiying MaJing Jin
Research 25 February 2026
Article: 190
Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria
在莫桑比克患疟疾的儿童中，蠕虫共感染可减轻临床、寄生虫学和免疫学转归
Inocência CuambaRebeca SantanoCarlota Dobaño
Research 31 March 2026
Article: 189
Effectiveness of group-based art interventions for late-life depression: a systematic review and meta-analysis of randomized controlled trials
团体艺术干预对老年抑郁症的疗效：一项针对随机对照试验的系统综述和荟萃分析
Mohamad AzhdarlooRaziyeh AtaeiAbouzar Nazari
Research 24 February 2026
Article: 188
The associations of consultant sex on herding‑like prescribing behaviour: evidence from a web-based experiment with female primary care physicians in England
顾问性别对从众式处方行为的影响：来自一项针对英格兰女性初级保健医生的网络实验的证据
Sandro Tiziano StoffelMatthias SchwenkglenksBerna Cennet Özdemir
Research 24 February 2026
Article: 187
Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients
三羧酸循环代谢物指数预测急性心肌梗死患者的不良预后
Ye WangPengyan WuBo Yu
Research 24 February 2026
Article: 186
Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids
靶向癌症干细胞可预测腹水来源的卵巢癌类器官的反应并逆转化疗耐药性
Xiaoli ZhangWen ZhangHuiqin Guo
Research 24 February 2026
Article: 185
Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk
青少年神经对压力的易感性：一项使用抑郁风险多连接组评分进行的纵向研究
Yuan LiuMeijuan LiJie Li
Research 24 February 2026
Article: 184
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Classification of ALS molecular subtypes: a literature review on machine learning applications and their clinical value
肌萎缩侧索硬化症分子亚型分类：机器学习应用及其临床价值的文献综述
John K. JammalEsteban A. GomezAlfredo Iacoangeli
Review 23 February 2026
Article: 183
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Can we protect refugee children from mental health problems?— a scoping review of modifiable factors to inform preventive interventions
我们能否保护难民儿童免受心理健康问题困扰？——一项旨在为预防性干预提供信息的可改变因素的范围性综述
Rita GonçalvesM J MarquesSónia Dias
Research 23 February 2026
Article: 182
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
The Trial Bank initiative to promote trustworthy living evidence for medication safety (PROMISE) of children: design and pilot validation
促进儿童用药安全可信实时证据（PROMISE）的试验库计划：设计与初步验证
Chang XuSuhail A. DoiPROMISE Collaborative Research Network
Research 21 February 2026
Article: 181
Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania
液体活检是否为诊断坦桑尼亚儿童和青年成人伯基特淋巴瘤的一种具有成本效益的方法？一项卫生经济学评估
Jingjing JiangLiz MorrellAI-REAL Consortium
Research 21 February 2026
Article: 180
The influence of immunohistochemistry-based subtypes on overall survival in breast cancer spine metastases: a systematic review and meta-analysis
基于免疫组织化学的亚型对乳腺癌脊柱转移总生存期的影响：一项系统综述和荟萃分析
Fon-Yih TsuangYun-Heng LiChung Liang Chai
Research 21 February 2026
Article: 179
Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children
产前接触母体哮喘及哮喘药物与神经发育结局的关系：一项针对179,024例儿童的人群队列研究
Lama A. ShakhshirSarjit SinghMichael Fleming
Research 20 February 2026
Article: 178
First-in-human phase 1/2a study of T3011, an oncolytic HSV expressing IL-12 and PD-1 antibody, administered via intratumoral (IT) injection as monotherapy in advanced solid tumors, including recurrent or metastatic HNSCC
T3011（一种表达IL-12和PD-1抗体的溶瘤性单纯疱疹病毒）首次人体1/2a期研究：通过瘤内（IT）注射作为单一疗法治疗包括复发或转移性头颈部鳞状细胞癌在内的晚期实体瘤
Dongmei JiWenmin FuXichun Hu
Research 20 February 2026
Article: 177
Expanding access to cerebrovascular imaging with routine MRI for pre-surgical assessment of intracranial tumor patients: an AI model development and multi-center validation study
利用常规MRI扩大脑血管成像在颅内肿瘤患者术前评估中的应用范围：一项人工智能模型开发与多中心验证研究
Chaoyue ChenZhouyang HuangJianguo Xu
Research 20 February 2026
Article: 176
Changing landscape of physical fitness and urban–rural inequalities: evidence from 1.2 million children and adolescents over 20 years of urbanization
20年城市化进程中120万例儿童和青少年体质健康状况及城乡差异的变化
Shan CaiJiaxin LiYi Song
Research 19 February 2026
Article: 175
Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis
抗糖尿病前期药物在糖尿病前期患者中的疗效和安全性：一项贝叶斯网状荟萃分析
Yike WuZihan WangGuo Ma
Research 19 February 2026
Article: 174
Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders
Yuefeng YuChenyi WanNingjian Wang
意义未明的克隆性造血与新发精神障碍风险
Research 18 February 2026
Article: 173
Spatial characterization of intrahepatic fat deposition across steatotic liver disease subcategories: a multicenter study
脂肪性肝病各亚类中肝内脂肪沉积的空间特征：一项多中心研究
Yan-Ci ZhaoMin WangFeng Chen
Research 18 February 2026
Article: 172
Pregnancy outcomes among medically complex populations with high risk of pregnancy mortality in Virginia: a retrospective observational study
弗吉尼亚州妊娠死亡高风险医学复杂人群的妊娠结局：一项回顾性观察研究
Michael J. GreenLauren G. AndersonJonas J. Swartz
Research 18 February 2026
Article: 171
Maternal amino acid metabolites during pregnancy and preterm birth: results from two prospective cohort studies
孕期母体氨基酸代谢物与早产的关系：两项前瞻性队列研究的结果
Jingnan ChenYidan DongJu-Sheng Zheng
Research 18 February 2026
Article: 170
Correction: Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications
更正：停用抗肥胖药物后体重的变化轨迹
Han WuWenjia YangLinong Ji
Correction 25 March 2026
Article: 169
Physical activity patterns and cardiovascular disease risk in adults with overweight or obesity: a prospective cohort study
超重或肥胖成人身体活动模式与心血管疾病风险：一项前瞻性队列研究
Kai MuYanan QiaoBo Xi
Research 16 February 2026
Article: 168
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减肥干预措施及其对健康的影响
Maternal migraine and offspring ADHD: triangulating the evidence
母亲偏头痛与后代多动症（ADHD）：多方证据综合分析
Yaxin LuoChristina DardaniEvie Stergiakouli
Research 14 February 2026
Article: 167
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson’s disease
靶向NLRP3的自主性小干扰RNA（siRNA）递送系统：在帕金森病中的潜在意义
Lishan LinZhizong LiZhong Pei
Research 12 February 2026
Article: 166
Lay descriptions of painful temporomandibular disorders—an international consensus proposal for Global Burden of Disease estimates
颞下颌关节紊乱病疼痛的通俗描述——全球疾病负担评估的国际共识提案
A. LövgrenP. LivP. Svensson
Research 17 March 2026
Article: 165
Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study
可溶性肿瘤坏死因子受体1与tau蛋白病变、脑萎缩及认知功能下降的关联：一项纵向研究
Yutong ZhangLulu SunAlzheimer’s Disease Neuroimaging Initiative
Research 11 February 2026
Article: 164
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Particulate matter and respiratory health in middle-aged and older adults: disentangling size-fractionated and constituent-specific effects under China’s clean-air policies
颗粒物与中老年人呼吸系统健康的关系：厘清中国净化空气政策下不同粒径及成分的特定影响
Yujing ChenZhaoyan LiuYu-ming Chen
Research 11 February 2026
Article: 163
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
Clinical impact and cost-effectiveness of vaccinating infants and adolescents against invasive meningococcal B disease in the Netherlands
荷兰为婴儿和青少年接种针对侵袭性脑膜炎球菌B病的疫苗的临床影响和成本效益
Thomas OttenMirjam KnolAnneke Steens
Research 10 February 2026
Article: 162
Association between trajectories of sleep quality and postpartum depression: a group-based trajectory model and computer-simulated network analysis
睡眠质量轨迹与产后抑郁之间的关联：基于组别的轨迹模型和计算机模拟网络分析
Xiaoxiao MeiJinzhou YuZengjie Ye
Research 10 February 2026
Article: 161
Part of 1 collection:Sleep and mental health
所属专题合集：睡眠与心理健康
Understanding Japan’s mortality advantage: a comparison of mortality in independent and dependent older adults in Japan and Sweden
解读日本在死亡率方面的优势：日本与瑞典独立生活及依赖他人生活老年人的死亡率比较
Shunsuke MurataMarcus EbelingKarin Modig
Research 23 March 2026
Article: 160
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用
The Young Adult Sleep model: an evolving causal loop diagram of mental health dynamics
青年睡眠模型：心理健康动态演变的因果环路图
Jeroen F. UlemanRushd F. M. Al-ShamaNaja Hulvej Rod
Research 16 March 2026
Article: 159
Part of 1 collection:Sleep and mental health
所属专题合集：睡眠与心理健康
Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma
基于抑瘤素M配体的CAR-T疗法对骨肉瘤显示出强大的抗肿瘤活性
Daniel FeinbergVinayak UppinReshmi Parameswaran
Research 17 March 2026
Article: 158
Antimicrobial catheters coated with poly-L-lysine for the prevention of bacteriuria in adults requiring short-term catheterization: a multicenter randomized controlled trial
涂有聚-L-赖氨酸的抗菌导管预防短期导尿成人患者菌尿症：一项多中心随机对照试验
Xinfei LiJun LiuKai Zhang
Research 09 February 2026
Article: 157
Penpulimab in combination with lenalidomide and R-GemOx regimen (R2-GemOx-PD1i) in relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm, phase 2 trial
派安普利单抗联合来那度胺和R-GemOx方案（R2-GemOx-PD1i）治疗复发或难治性弥漫性大B细胞淋巴瘤：一项多中心、单臂、2期试验
Jin-Hua LiangTong-Yao XingWei Xu
Research 09 February 2026
Article: 156
Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus
数字孪生大脑揭示耳鸣异常脑动力学状态特异性刺激靶点
Jiaqi ZhangShuting HanTianzi Jiang
Research 10 February 2026
Article: 155
The case for mandatory reporting to enable targets for healthy and environmentally sustainable food: means, motive and opportunity
强制报告实现健康且环境可持续食物目标的理由：方法、动机和机会
Rachel PecheyLauren BandySusan A. Jebb
Debate 10 February 2026
Article: 154
Genetic insights into radiomic and proteomic changes under β1-blockers treatment in hypertensive heart disease and hypertrophic cardiomyopathy
β1受体阻滞剂治疗高血压性心脏病和肥厚型心肌病时放射组学和蛋白质组学变化的遗传学见解
Zhe ChenYifan TangKai Xie
Research 09 February 2026
Article: 153
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病与心律失常
Optimizing drug-resistant tuberculosis diagnosis: cost-effectiveness of rapid molecular and phenotypic assays in South Africa
优化耐药结核病诊断：南非快速分子和表型检测方法的成本效益分析
Ginenus FekaduTadesse TolossaWai Kit Ming
Research 09 February 2026
Article: 152
Maternal smoking based on pre-birth health examination and risk of neurodevelopmental disorders in offspring: insights from a Korean mother–child cohort
基于产前健康检查探讨母亲吸烟与后代神经发育障碍风险的关系：来自韩国母婴队列研究的见解
Chan Soon ParkMoonyoung JangJun-Bean Park
Research 11 March 2026
Article: 151
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Effects of ablation versus drug therapy on clinical outcomes and quality of life by frailty status in atrial fibrillation: a post hoc analysis of the CABANA trial
根据衰弱状态分析消融术与药物治疗对心房颤动患者临床预后和生活质量的影响：CABANA试验的事后分析
Lili WangYanguang LiYunlong Wang
Research 07 February 2026
Article: 150
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病与心律失常
Quantifying lifetime risk for 1,401 infectious diseases across the diabetes spectrum using a Bayesian approach
采用贝叶斯方法量化糖尿病全病程中1401种传染病的终生风险
Boomer B. OlsenMartin Tristani-FirouziEdgar Javier Hernandez
Research 07 February 2026
Article: 149
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与传染病
Risk assessment of asthma and allergic rhinitis in atopic dermatitis patients treated with biologics and JAK inhibitors: a systematic review and network meta-analysis of randomized controlled trials
对接受生物制剂和JAK抑制剂治疗的特应性皮炎患者罹患哮喘和过敏性鼻炎的风险评估：一项针对随机对照试验的系统综述和网络荟萃分析
Liling ZengTong ZhouJing Li
Research 07 February 2026
Article: 148
Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma
布林西多福韦（brincidofovir）在外周T细胞和NK/T细胞淋巴瘤中的临床前活性
Jason Yongsheng ChanElizabeth Chun Yong LeeChoon Kiat Ong
Research 06 February 2026
Article: 147
Genetic risk factors modulate the association between physical activity and colorectal cancer
遗传风险因素调节身体活动与结直肠癌之间的关联
Anita R. PeoplesMireia Obón-SantacanaVictor Moreno
Research 05 February 2026
Article: 146
A neuroimaging biomarker for disease staging in clinically diagnosed Alzheimer’s disease
临床诊断阿尔茨海默病的疾病分期神经影像学标志物
Zhuangzhuang LiShaozhen YanYong Liu
Research 05 February 2026
Article: 145
Association of GLP-1 receptor agonists with herpes risks in diabetes mellitus: a target trial emulation
胰高血糖素样肽-1（GLP-1）受体激动剂与糖尿病中疱疹风险的关联：一项目标试验模拟研究
Chi-Hsien HuangI-Hui ChiangJames Cheng-Chung Wei
Research 31 December 2025
Article: 144
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与感染性疾病
Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial
局部晚期胃癌联合胸腺肽的新辅助免疫化疗：一项前瞻性临床试验
Hao XuFengyuan LiZekuan Xu
Research 26 February 2026
Article: 143
Part of 1 collection:Clinical trials for gastrointestinal cancer
所属专题合集：胃肠道癌症的临床试验
Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis
临床医生在临床复查中检测急性脑膜炎后遗症：一项系统综述和荟萃分析
Luisa F. AlvizCarla Y. KimKiran T. Thakur
Research 28 February 2026
Article: 142
Part of 1 collection:Acute meningitis: a collection of systematic reviews
所属专题合集：急性脑膜炎：系统综述合集
ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics
ISG15驱动的免疫调节与乳腺癌转移中的肿瘤进展：来自单细胞和空间转录组学的见解
Hua ShaoHanlu TangYongqing Xu
Research 04 February 2026
Article: 141
Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk
评估家族史和多基因风险评分对心代谢疾病风险的影响
Ebuka OnyenobiKnightess OyiboSally N. Adebamowo
Research 03 February 2026
Article: 140
Social networking site use, depressive and anxiety symptoms in adolescents: evidence from a longitudinal cohort study (SCAMP)
社交网站使用与青少年抑郁和焦虑症状：来自纵向队列研究（SCAMP）的证据
Chen ShenBraulio M. Girela-SerranoMireille B. Toledano
Research 03 February 2026
Article: 139
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel
使用经验证的三蛋白血清生物标志物组合进行早孕期自发性早产预测
Qiong LuoJuan WeiXuefeng B. Ling
Research 02 February 2026
Article: 138
Household cannabis cessation and adolescent mental health outcomes in a prospective cohort study
一项前瞻性队列研究中家庭大麻戒断与青少年心理健康预后的关系
Ming WangYixiang XuFei Li
Research 02 February 2026
Article: 137
Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies
所属专题合集：精神活性物质：娱乐性药物重新利用为新型疗法
Objective assessment of long-term impact of COVID-19 on multiple sensory functions
客观评估新冠肺炎对多种感觉功能的长期影响
Ahmad OdehVeronica L. FormanekKai Zhao
Research 27 February 2026
Article: 136
Detection of hearing loss by formal audiological testing after acute infectious meningitis: a global systematic review and meta-analysis
急性感染性脑膜炎后通过正式听力检测诊断听力损失：一项全球系统综述和荟萃分析
Luisa F. AlvizCarla Y. KimKiran T. Thakur
Review 28 February 2026
Article: 135
Part of 1 collection: Acute meningitis: a collection of systematic reviews
所属专题合集：急性脑膜炎：系统综述合集
Serological evidence of substantial respiratory syncytial virus infection burden among older adults residing in Swedish long-term care facilities
血清学证据表明，居住在瑞典长期护理机构中的老年人存在沉重的呼吸道合胞病毒感染负担
Preeti MoarChristoffer GranvikMattias N. E. Forsell
Research 24 February 2026
Article: 134
Association of parental education with offspring psychiatric diagnoses, violent crimes, and suicidal behavior: a nationwide Swedish quasi-experimental study
父母受教育程度与后代精神疾病诊断、暴力犯罪和自杀行为之间的关联：一项瑞典全国范围的准实验研究
Mengping ZhouHenrik LarssonErik Pettersson
Research 26 February 2026
Article: 133
Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis
外部验证的痴呆风险预测模型的鉴别性能：一项系统综述和荟萃分析
Blossom C. M. StephanJacob BrainMario Siervo
Research 02 February 2026
Article: 132
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study
静脉注射大剂量硒预防铂敏感复发性卵巢癌化疗所致周围神经病变的有效性和安全性：一项3期、双盲、平行组、随机对照试点研究
Ga Won YimKyung Hee HanHee Seung Kim
Research 02 February 2026
Article: 131
Time for change in implementation research and practice
实施研究和实践中变革的时机已到
Mike EnglishJacob McKnightSebastian Fuller
Debate 02 February 2026
Article: 130
CardioMetAge estimates cardiometabolic aging and predicts disease outcomes
CardioMetAge可评估心脏代谢年龄并预测疾病结局
Yucan LiXinming XuKelin Xu
Research 31 January 2026
Article: 129
Disproportionate climate burden of rising temperatures on low birth weight in Pakistan
气温上升给巴基斯坦低出生体重儿带来的不成比例的气候负担
Syeda H. FatimaCorey J. A. BradshawZohra S. Lassi
Research 31 January 2026
Article: 128
Part of 1 collection: Climate change and human health
所属专题：气候变化与人类健康
Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy
利用靶向CD3ε、EpCaM和4-1BB的三特异性T细胞衔接器增强溶瘤病毒疗法：临床前评估及对癌症免疫疗法的启示
Zhongyi DongHaoyu ZhangZizhen Zhang
Research 30 January 2026
Article: 127
Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma
靶向降解BCL-XL与吉西他滨联用对胆管癌具有协同治疗作用
Qinghua ZengYan ZhangYonghan He
Research 30 January 2026
Article: 126
Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4
DNA甲基化与高血压及血压的关联：来自KORA F4/FF4的7年纵向研究
Liye LaiAngelina Shin Yee JongMelanie Waldenberger
Research 04 February 2026
Article: 125
Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis
精神活性物质使用与泛癌症的共享遗传结构：来自大规模全基因组跨性状分析的见解
Jiahang SongPengzhu LiOlivier Gires
Research 05 February 2026
Article: 124
Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies
所属专题：精神活性物质：作为新型疗法的娱乐性药物再利用
Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children
宫内暴露于母体糖尿病与儿童患癫痫风险的关系：一项针对230万儿童的全国队列研究
Muhammad Zakir HossinMartina PerssonNeda Razaz
Research 14 February 2026
Article: 123
ADHD and adherence to antihypertensive medication treatment: a multinational cohort study
多动症与坚持抗高血压药物治疗的关系：一项多国队列研究
Honghui YaoYiling ZhouZheng Chang
Research 20 February 2026
Article: 122
How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project
重新加入长期减肥计划的效果如何？5年和10年磁共振成像评估的随访干预试验（FIT）项目
Hadar KleinDafna PachterIris Shai
Research 30 January 2026
Article: 121
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减肥干预措施及其对健康的影响
Correction: Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings
更正：精神分裂症患者及其未受影响兄弟姐妹的脑状态动态与工作记忆
Feiwen WangJie YangLena Palaniyappan
Correction 20 February 2026
Article: 120
Ocular light and optical radiation exposure as a modifiable environmental determinant of health: expert consensus on research gaps and priorities
作为可改变的环境健康决定因素的眼睛光暴露和光学辐射暴露：关于研究空白和优先事项的专家共识
Manuel SpitschanAnna M. BillerJohannes Zauner
Guideline 29 January 2026
Article: 119
Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study
青少年饮食模式与神经心理功能：一项横断面和纵向研究
Alexios ManidisNicolas Ayala-AldanaJordi Julvez
Research 29 January 2026
Article: 118
Part of 1 collection: Child and adolescent psychiatry
所属专题：儿童与青少年精神病学
Factors impacting the delivery of contextualized care in serious illness: a focus group study with healthcare professionals
影响危重症患者情境化护理实施的因素：一项针对医疗保健专业人员的焦点小组研究
Linda ModderkolkYvonne SchoonAnne B. Wichmann
Research 29 January 2026
Article: 117
Part of 1 collection: Palliative care and medicine
所属专题：姑息治疗与医学
Early interventions for first onset of symptoms of mental health conditions: an umbrella review of systematic reviews
针对心理健康问题首次出现症状的早期干预措施：一项系统综述的伞式评价
Jasmine LeePhoebe BarnettSonia Johnson
Research 29 January 2026
Article: 116
Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone
局灶性癫痫发作间期脑电图信号中嵌入的谐波模式：对致痫区的新见解
Lingli HuLingqi YeShuang Wang
Research 28 January 2026
Article: 115
Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题合集：癫痫：发作预防、治疗和流行病学
Effects of aerobic or resistance exercise on sleep and cancer-related fatigue in patients with breast cancer during or after neoadjuvant chemotherapy: a 3-arm randomized controlled trial
有氧运动或抗阻运动对新辅助化疗期间或之后乳腺癌患者睡眠和癌症相关疲劳的影响：一项三臂随机对照试验
Alexander HaussmannMartina E. SchmidtKaren Steindorf
Research 28 January 2026
Article: 114
Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis
中性粒细胞甲基丙二酸通过激活IL-6信号通路介导的中性粒细胞胞外诱捕网形成（NETosis），促进心肌梗死后微血栓形成和不良心脏重构
Yige LiuJiaxin WangShaohong Fang
Research 28 January 2026
Article: 113
Statistical approaches to analyse the combined effect of seven air pollutants and breast cancer risk: a case–control study nested in the French E3N-Generations cohort
分析七种空气污染物联合作用与乳腺癌风险关系的统计方法：一项嵌套于法国E3N-Generations队列的病例对照研究
Camille GiampiccoloBéatrice FerversAmina Amadou
Research 28 January 2026
Article: 112
Part of 1 collection: Carcinogens and human health
所属专题合集：致癌物与人类健康
Is behaviour change communication guidance for general practice healthcare professionals evidence based? A systematic review
针对全科医疗保健专业人员的行为改变沟通指导是否具有循证依据？一项系统综述
Anika Schwarze-ChintapatlaJonathan Livingstone-BanksCharlotte Albury
Research 16 February 2026
Article: 111
Patient-centred postpartum care provision: virtual delivery, tiered escalation, and tensions between efficiency, preference, and clinical concern
以患者为中心的产后护理服务提供：虚拟服务模式、分级转诊机制，以及效率、患者偏好与临床关切之间的矛盾
Sergio A. SilverioJulia R. B. BrownEmma L. Duncan
Research 24 February 2026
Article: 110
Ethical dilemmas in climate change and healthcare delivery: a cross-sectional survey of US patient perspectives
气候变化与医疗服务中的伦理困境：一项针对美国患者观点的横断面调查
Andrew HantelEmily SenayGregory A. Abel
Research 27 January 2026
Article: 109
Part of 1 collection: Climate change and human health
所属专题：气候变化与人类健康
Inetetamab plus camrelizumab and utidelone for pretreated HER2-positive advanced breast cancer: a prospective, single-arm, phase 2 study
伊尼妥单抗联合卡瑞利珠单抗和优替德隆治疗既往接受过治疗的HER2阳性晚期乳腺癌：一项前瞻性、单臂、2期研究
Huimin LvTao SunMin Yan
Research 27 January 2026
Article: 108
Potential of earlier primary care health checks for prevention of cardiovascular events in younger age groups: population-based study in the United Kingdom
早期初级保健健康检查对预防年轻人群心血管事件的潜力：英国一项基于人群的研究
Catherine A. ScottLinxin LiPeter M. Rothwell
Research 24 January 2026
Article: 107
Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis
盐替代品对血压、心血管事件和死亡率影响的比较：一项系统综述和网络荟萃分析
Honghao LaiGihad NesrallahBradley C. Johnston
Research 23 January 2026
Article: 106
Association of short-term exposure to ambient air pollutants with liver function and mediation by fasting insulin: evidence from a rural cohort in China
短期暴露于环境空气污染物与肝功能的关系及空腹胰岛素的中介作用：来自中国农村队列研究的证据
Mengxin WangAogang ZhangWeidong Wu
Research 23 January 2026
Article: 105
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Adjuvant tislelizumab, lenvatinib, and capecitabine for resected biliary tract cancer: a prospective phase II trial
辅助治疗：替雷利珠单抗、仑伐替尼和卡培他滨用于可切除的胆道癌：一项前瞻性II期试验
Yun FengNing ZhangLu Wang
Research 23 January 2026
Article: 104
Comparative effectiveness of sleeve gastrectomy and semaglutide for weight loss and metabolic outcomes: a prospective non-randomized study
袖状胃切除术与司美格鲁肽对减重及代谢结局的疗效比较：一项前瞻性非随机研究
Yutung YenQian ZhangYi Chen
Research 22 January 2026
Article: 103
Part of 1 collection:Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
Impact of sex on outcomes in patients treated with drug-coated balloons versus drug-eluting stents for de novo coronary artery lesions: Insights from the REC-CAGEFREE I trial
性别对接受药物涂层球囊与药物洗脱支架治疗的新发冠状动脉病变患者预后的影响：来自REC-CAGEFREE I试验的见解
Ping WangJingyu ZhouLing Tao
Research 22 January 2026
Article: 102
Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models
通过多基因风险评分和时间事件模型评估哮喘与抑郁的共病情况
Xueting WangJun HeRenato Polimanti
Research 22 January 2026
Article: 101
Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition
严重营养不良儿童出院后持续存在的免疫、凝血和心脏功能失调与后期死亡率相关
Brenda KamauEvans O. MudiboJames M. Njunge
Research 22 January 2026
Article: 100
Correction: Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022
更正：计算机辅助口头尸检：对比大型语言模型与医生为2019 - 2022年塞拉利昂6939例死亡分配病因的情况
Richard WenAnteneh Tesfaye AssalifRashid Ansumana
Correction 14 February 2026
Article: 99
Characteristics of parks associated with depression in women only: a cross-sectional study of 329,363 adults
仅与女性抑郁相关的公园特征：一项针对329,363名成年人的横断面研究
Jonathan R. OlsenNatalie NichollsRichard Mitchell
Research 21 January 2026
Article: 98
Weight change mediates the effect of lifestyle intervention on postpartum diabetes in women with prior gestational diabetes: a secondary analysis of a randomized clinical trial
在生活方式干预对既往妊娠期糖尿病女性产后糖尿病影响中，体重变化的中介作用：一项随机临床试验的二次分析
Weiqin LiHuikun LiuGang Hu
Research 21 January 2026
Article: 97
Part of 1 collection: Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与治疗
Global drivers of heart failure attributable to atrial fibrillation/flutter: insights fromJoinpoint regression, age-period-cohort analysis, and future projections from the GBD 2021 Study
心房颤动/扑动所致心力衰竭的全球驱动因素：来自折点回归、年龄-时期-队列分析以及2021年GBD（全球疾病负担）研究未来预测的见解
Jing ChenZhu LiGregory Y. H. Lip
Research 20 January 2026
Article: 96
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Overdiagnosis of gestational diabetes mellitus during Ramadan: a retrospective population-based study in Catalonia, Spain
斋月期间妊娠期糖尿病的过度诊断：西班牙加泰罗尼亚地区一项基于人群的回顾性研究
Marta CarrascoBogdan VlachoMarta Hernández
Research 20 January 2026
Article: 95
Part of 1 collection: Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与管理
Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England
为何当前基于风险因素的方法在预测死胎方面存在不足：英格兰初产妇全国队列研究
A. HowellB. ThilaganathanTommy’s National Centre for Maternity Improvement
Research 22 January 2026
Article: 94
Pay-it-forward intervention increased pneumococcal vaccine uptake among older adults in China: a randomized controlled trial
爱心传递干预措施提高了中国老年人肺炎球菌疫苗的接种率：一项随机对照试验
Jiao QinChunxing TaoBingyu Liang
Research 19 January 2026
Article: 93
The impact of e-cigarette taxation: a systematic review and meta-analysis on usage, pricing strategies, and public health implications
电子烟税收的影响：针对使用情况、定价策略和公共卫生影响开展的系统综述和荟萃分析
Quan WangZheng ZhuLi Yang
Research 17 January 2026
Article: 92
Safety and preliminary efficacy results of IBI389, an anti-Claudin18.2×CD3 bispecific antibody, in patients with solid tumors and gastric or gastro-esophageal tumors: a phase 1 dose escalation and expansion study
抗Claudin18.2×CD3双特异性抗体IBI389在实体瘤及胃或胃食管肿瘤患者中的安全性与初步疗效结果：一项1期剂量递增与扩展研究
Xiaoyu LiRuihong DaiFeng Bi
Research 16 January 2026
Article: 91
Part of 1 collection: Clinical trials for gastrointestinal cancer
所属专题：胃肠道癌症临床试验
Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study
比较非癌症疼痛使用阿片类药物者发生谵妄的风险：一项回顾性队列研究
Carlos Raul Ramirez MedinaMark LuntMeghna Jani
Research 31 January 2026
Article: 90
Association between preoperative interruption of antiplatelet therapy and postoperative thrombotic risk after minimally invasive surgery for abdominopelvic cancer in patients treated with P2Y12 inhibitors
接受P2Y12抑制剂治疗的患者行腹部盆腔癌症微创手术时，术前中断抗血小板治疗与术后血栓形成风险之间的关联
Masashi KubotaSatomi YoshidaKoji Kawakami
Research 16 January 2026
Article: 89
Comparative outcomes of distal ureterectomy vs. radical nephroureterectomy in high-risk distal ureteral urothelial carcinoma: a two-center cohort study in Northern and Southern China
高危远端输尿管尿路上皮癌患者行远端输尿管切除术与根治性肾输尿管切除术的疗效比较：中国北方和南方两家中心的队列研究
Junyi XieZhenhua LiuWei Yu
Research 16 January 2026
Article: 88
Co-occurrence patterns and related risk factors of dementia and Parkinson’s disease among older adults across 204 countries and territories: a spatial correspondence and systematic analysis
204个国家和地区老年人痴呆症与帕金森病共现模式及相关危险因素：空间对应与系统分析
Weiyang ChenMin DuJue Liu
Research 15 January 2026
Article: 87
Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study
肌萎缩侧索硬化症加速脑衰老及其预后关联：一项队列研究
Chenhao FangJiaoting JinShuoqiu Gan
Research 15 January 2026
Article: 86
Part of 1 collection: Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题：肌萎缩侧索硬化症：最新进展与新动态
The clinical effects and cortical mechanism of rTMS in poststroke lateropulsion: a randomized controlled trial
重复经颅磁刺激（rTMS）对脑卒中后侧方倾倒的临床效果及皮质机制：一项随机对照试验
Lijiao MengRaymond C. C. TsangQuan Wei
Research 14 January 2026
Article: 85
5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice
中脑背侧缝际核谷氨酸能神经元中的5-HT2C受体调控小鼠疼痛与焦虑共病
Qi ZhangLi XieRiyue Jiang
Research 13 January 2026
Article: 84
The clinical landscape of POLE-mutant colorectal cancer: a retrospective analysis of real-world outcome
POLE突变型结直肠癌的临床现状：一项现实结局的回顾性分析
Ting XuXuhui ZhangJian Li
Research 13 January 2026
Article: 83
The efficacy and safety of duloxetine in treating refractory chronic cough: a randomized clinical trial
度洛西汀治疗难治性慢性咳嗽的有效性和安全性：一项随机临床试验
Shengyuan WangHeng WuXianghuai Xu
Research 13 January 2026
Article: 82
Impact of diagnosis to ablation time on clinical outcomes in patients with atrial fibrillation: post hoc analysis of the CABANA trial
心房颤动患者从诊断到消融的时间对临床预后的影响：CABANA试验的事后分析
Manlin ZhaoYang ChenGregory Y. H. Lip
Research 12 January 2026
Article: 81
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Elevated maternal pre-transfer serum lipid peroxidation is associated with implantation failure and early pregnancy loss
母体转运前血清脂质过氧化水平升高与着床失败和早期流产相关
Zhangwei JiaJunxiang RenJunhao Yan
Research 12 January 2026
Article: 80
Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer
幽门螺杆菌感染对肠道和肿瘤内微生物组的影响及其与胃肠道癌症免疫治疗反应的关联
Keren JiaYang ChenLin Shen
Research 12 January 2026
Article: 79
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物组：人类疾病的新疗法
SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis
SGLT-2抑制剂在2型糖尿病合并代偿性肝硬化患者中的应用及其对肝脏相关预后和死亡率的影响
Tien-Shin ChouDaniel Hsiang-Te TsaiEdward Chia-Cheng Lai
Research 12 January 2026
Article: 78
Extrapolating from trials to clinic: a predictive model defining the boundaries of benefit for multiple sclerosis therapies in real-world populations based on systematic review
从试验外推至临床：基于系统综述构建预测模型，界定多发性硬化症疗法在现实人群中的获益边界
Bibiana BielekovaTianxia WuMichael Calcagni
Research 10 January 2026
Article: 77
A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data
利用最少患者数据早期预测坏死性软组织感染A组链球菌病因的验证模型
Sonja KatzJaco SuijkerEdoardo Saccenti
Research 10 January 2026
Article: 76
Trends in lipid-lowering therapies in acute coronary syndromes after Chinese new insurance policy: a real-world analysis
中国新医保政策实施后急性冠状动脉综合征患者降脂治疗趋势：一项现实情况分析
Xin ZhaoShujing WuJunbo Ge
Research 09 January 2026
Article: 75
Fragmented healthcare and effective maternal coverage in Mexico, 2009–2023
2009-2023年墨西哥医疗体系碎片化与有效孕产妇医疗保障
Edson Serván-MoriDiego Cerecero-GarcíaOctavio Gómez-Dantés
Research 09 January 2026
Article: 74
Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models
昼夜节律紊乱与心血管疾病：基于动物模型机制证据的系统综述与荟萃分析
Mrinal K. DasEvi De RyckJohanna Samulin Erdem
Research 09 January 2026
Article: 73
Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults
衰弱进展：多重共病组合模式在老年人衰弱状态转变及死亡风险预测中的作用
Rafael Ogaz-GonzálezQian ZouEva Corpeleijn
Research 08 January 2026
Article: 72
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials
益生菌补充剂对健康人群肠道微生物群多样性的影响：一项针对随机对照试验的系统综述和荟萃分析
Anna Júlia ÉliásKincső Csepke Földvári-NagyLászló Földvári-Nagy
Research 07 January 2026
Article: 71
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物群：人类疾病的新疗法
Pain and high-impact pain in community-dwelling older adults in Australia and relation to sociodemographic and health-related factors, including physical disability, psychological distress, and quality of life
澳大利亚社区居住老年人的疼痛及重度疼痛情况，及其与社会人口统计学因素和健康相关因素（包括身体残疾、心理困扰和生活质量）的关系
Grace JoshySaman Khalatbari-SoltaniEmily Banks
Research 22 January 2026
Article: 70
Mortality and morbidity burden associated with smoking: evidence from a 1.6 million cohort in Hong Kong
与吸烟相关的死亡率和发病率负担：来自香港160万人队列研究的证据
Boyuan WangTingting ChenEric Yuk Fai Wan
Research 06 January 2026
Article: 69
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Association between long-term extreme high temperature and mortality: a 9-million prospective cohort study
长期极端高温与死亡率之间的关系：一项900万人的前瞻性队列研究
Bo YinQi HuangKuiying Gu
Research 06 January 2026
Article: 68
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach
利用网络毒理学和分子对接方法揭示氨甲环酸诱发癫痫的神经毒性机制
Tianyang ChenDalong LiuXiangYang Leng
Research 03 January 2026
Article: 67
Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题：癫痫：癫痫发作的预防、治疗和流行病学
Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study
Trop2免疫正电子发射断层扫描/计算机断层扫描（PET/CT）成像在前列腺癌中的应用：一项概念验证性转化研究
Xingru LongShuxian AnDawei Jiang
Research 31 December 2025
Article: 66
Methylmalonate accumulation contributes to myocardial vulnerability post-reperfusion: a novel therapeutic target and prognostic biomarker
甲基丙二酸蓄积促进再灌注后心肌脆弱性：一种新型治疗靶点和预后生物标志物
Shanjie WangJunChen GuoShaohong Fang
Research 31 December 2025
Article: 65
Prophylactic effect of intraoperative sodium oxybate on postoperative delirium in older patients undergoing major orthopedic surgery: a randomized clinical trial
术中羟丁酸钠对接受大型骨科手术的老年患者术后谵妄的预防作用：一项随机临床试验
Meiying CuiHang XuePing Zhao
Research 31 December 2025
Article: 64
Part of 1 collection:Psychoactives: Recreational drugs repurposed as novel therapies
所属专题：精神活性物质：将娱乐性药物重新用于新型疗法
Prevalence of hysterectomy in urban China and associations between metabolic disorders and hysterectomy: a multicenter population-based study involving over 9 million women
中国城市子宫切除术的流行情况以及代谢紊乱与子宫切除术之间的关系：一项涉及超过900万女性的多中心人群基础研究
Yanrui BiYuan MaYing Gao
Research 30 December 2025
Article: 63
Sex differences in cardiac risk and kidney function: serum creatinine versus cystatin C
心脏风险和肾功能方面的性别差异：血清肌酐与胱抑素C的对比
Nicole L. De La MataJames A. HedleyJennifer S. Lees
Research 30 December 2025
Article: 62
The association of post-conization pregnancy with subsequent cervical lesions: evidence from a nationwide cohort in Sweden
锥切术后妊娠与后续宫颈病变的关联：来自瑞典全国队列研究的证据
Huan YiJimiao HuangJianguang Ji
Research 29 December 2025
Article: 61
Tibial periosteal distraction for ischemic leg ulcers: animal and clinical cohort study
胫骨骨膜牵张术治疗缺血性下肢溃疡：动物及临床队列研究
Peilin ZhouWenqiang WangQikai Hua
Research 28 December 2025
Article: 60
Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study
卡瑞利珠单抗联合紫杉醇和奈达铂对不可切除的晚期食管鳞癌的术前转化治疗：一项2期研究
Jinhong ZhuJinfeng ZhangJianqun Ma
Research 28 December 2025
Article: 59
Clustering of cardiometabolic risk factors, physical activity, digital exclusion, and depressive symptoms trajectories in adults aged 50years and older: findings from two prospective cohort studies
50岁及以上成年人心血管代谢风险因素聚集、身体活动、数字排斥及抑郁症状轨迹：两项前瞻性队列研究的发现
Xiaosheng DongJiaqiang XiaoChengchao Zhou
Research 28 December 2025
Article: 58
Eligibility of real-world patients for aspirin primary prevention trials in cardiovascular disease
现实中符合心血管疾病阿司匹林一级预防试验资格的患者情况
Michael HolderDaniel R. MoralesBruce Guthrie
Research 27 January 2026
Article: 57
Polygenic risk score-guided personalized osteoporosis screening: a population-based study
基于多基因风险评分指导的个性化骨质疏松症筛查：一项基于人群的研究
Dongxue WangWen SunJianguang Ji
Research 14 January 2026
Article: 56
Urea cycle modulation by combined SGLT2 inhibitors and metformin
SGLT2抑制剂与二甲双胍联合用药对尿素循环的调节作用
Makoto HaradaJonathan AdamRui Wang-Sattler
Research 08 January 2026
Article: 55
Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study
VCP抑制剂ML240在大型动物及人视网膜外植体中的安全性和神经保护功效：一项临床前离体研究
Ana-Cristina Almansa-GarcíaAngela ArmentoBlanca Arango-Gonzalez
Research 10 January 2026
Article: 54
Impact of an eight-week isocaloric vegan dietary intervention on hemogram parameters and lymphocyte subsets: a randomized-controlled trial
为期八周的等热量纯素饮食干预对血细胞参数和淋巴细胞亚群的影响：一项随机对照试验
Julian HerterFrieda StübingMaximilian Andreas Storz
Research 10 January 2026
Article: 53
Association between psychosocial factors and adverse effects of light-to-moderate ambient heat in patients with chronic diseases: results of the prospective cohort study CLIMATE-II
社会心理因素与轻至中度环境热对慢性病患者不良影响之间的关联：前瞻性队列研究CLIMATE-II的结果
Ingmar SchäferValentina PauckeDagmar Lühmann
Research 15 January 2026
Article: 52
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Maternal infection during pregnancy and the risk of childhood cancer: a systematic review and meta-analysis
孕期母体感染与儿童期患癌风险：一项系统综述和荟萃分析
Loviisa MulanjeLara Kim BrackmannRajini Nagrani
Research 14 January 2026
Article: 51
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Supplementary biomarker testing in molecular tumor boards increases actionable therapy recommendations: a prospective real-world study of 658 patients
分子肿瘤委员会中的补充生物标志物检测增加了可采取治疗措施的建议：一项针对658例患者的前瞻性真实世界研究
Alexander ScheiterSimon MellinKirsten Utpatel
Research 14 January 2026
Article: 50
Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022
计算机辅助口头尸检：对比大型语言模型与医生对塞拉利昂2019 - 2022年6939例死亡原因的判定
Richard WenAnteneh Tesfaye AssalifRashid Ansumana
Research 24 December 2025
Article: 49
Loss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank
Y染色体缺失及其在男性肌萎缩侧索硬化症中的影响：来自英国生物银行的研究见解
Wei-Ming SuQing-Qing DuanYong-Ping Chen
Research 24 December 2025
Article: 48
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题：肌萎缩侧索硬化症：最新进展与新动态
Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner
产前脂多糖暴露通过调节间充质成纤维细胞以时间和剂量依赖性方式来影响早期肺部发育
Ying DongStefan HadzicSaverio Bellusci
Research 22 December 2025
Article: 47
Life course socioeconomic trajectories and chronic disease risk in later life among 30,055 older adults across 27 European countries (the SHARE study)
27个欧洲国家30,055名老年人生命历程中的社会经济轨迹与晚年慢性疾病风险（基于SHARE研究）
Taymara C. AbreuJoline W. J. BeulensJoreintje D. Mackenbach
Research 20 December 2025
Article: 46
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学与风险因素的作用
Validation of a novel patient-reported measure of the burden of digital care in diabetes
由糖尿病患者报告的数字化护理负担新型测评工具的验证
Misk Al ZahidyJennifer L. RidgewayVictor M. Montori
Research 20 December 2025
Article: 45
Determinants of long-term SARS-CoV-2 immune responses in asymptomatic-to-moderate COVID-19 patients in sub-Saharan Africa
撒哈拉以南非洲地区无症状至中度 COVID-19 患者长期 SARS-CoV-2 免疫应答的决定因素
Víctor L. de RiojaOdin GoovaertsGemma Moncunill
Research 14 January 2026
Article: 44
Camrelizumab and apatinib in Chinese patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid cancer: an exploratory open-label, single-arm trial
卡瑞利珠单抗联合阿帕替尼治疗中国局灶性晚期或转移性放射性碘难治性分化型甲状腺癌：一项探索性开放标签单臂试验
Xin ZhangDi SunYansong Lin
Research 18 December 2025
Article: 43
Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial
地中海饮食的尿液多酚特征与心血管疾病风险较低相关：PREDIMED 试验
Inés Domínguez-LópezPolina GalkinaRosa M. Lamuela-Raventós
Research 18 December 2025
Article: 42
Meta-analysis and external validation of a risk model for gastrointestinal bleeding after percutaneous coronary intervention
经皮冠状动脉介入治疗后胃肠道出血风险模型的荟萃分析及外部验证
Hualong MaCong PengQiaohong Yang
Research 18 December 2025
Article: 41
DNA methylation-based clocks, tobacco smoking, and lung cancer risk
基于DNA甲基化的生物钟、烟草吸烟与肺癌风险
Ricardo Cortez Cardoso PenhaJustina Ucheojor OnwukaMattias Johansson
Research 17 December 2025
Article: 40
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70years old
认知功能未受损的70岁老年人基于人口的队列中，与大脑灰质模式相关的风险和保护因素
Giulia LorenzonAnna MarsegliaEric Westman
Research 17 December 2025
Article: 39
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学和风险因素的作用
Street view-derived city built environment and vulnerability to temperature extremes: a nationally representative population-based cohort study
基于街景图像的城市建成环境与极端温度脆弱性：一项全国代表性人口队列研究
Wanzhou WangChao YangLuxia Zhang
Research 16 December 2025
Article: 38
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity
针对病毒变异株的灭活严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）疫苗加强针可维持保护性体液免疫和细胞免疫
Constanza MéndezLinmar Rodríguez-GuilarteSusan M. Bueno
Research 15 December 2025
Article: 37
Dapagliflozin alleviates sunitinib-induced cardiotoxicity through AMPKα-PPARα axis and enhances the sensitivity of renal cell carcinoma to sunitinib
达格列净通过AMPKα-PPARα轴减轻舒尼替尼诱导的心脏毒性，并增强肾细胞癌对舒尼替尼的敏感性
Shi-yu HuangMin HuLei Wang
Research 15 December 2025
Article: 36
Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study
新诊断癫痫患者言语流畅性缺陷背后的网络功能障碍：一项静息态功能磁共振成像功能连接研究
Fangzhou LiuPing JiangLing Liu
Research 13 December 2025
Article: 35
Part of 1 collection:Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题：癫痫：癫痫发作的预防、治疗和流行病学
Long-term quality of life in non-epithelial ovarian cancer survivors: TMRG-GINECO-Vivrovaire rare tumors case–control study
基于广西新生儿地中海贫血基因组图谱计划开展的家庭三联体/四联体分析
Coraline DubotIsabelle Ray-CoquardFlorence Joly
Research 12 December 2025
Article: 34
Family trios/quartets analysis based on the Newborn Genomic Atlas for Thalassemia project in Guangxi
非上皮性卵巢癌幸存者的长期生活质量：TMRG-GINECO-Vivrovaire罕见肿瘤病例对照研究
Wei WeiChunrong GuiBaoheng Gui
Research 12 December 2025
Article: 33
Hyperuricemic persons use more analgesics than normouricemic—is asymptomatic hyperuricemia really asymptomatic?
高尿酸血症患者比血尿酸正常者使用更多镇痛药——无症状性高尿酸血症真的“无症状”吗？
Janis TimsansJenni Emilia KauppiMarkku Kauppi
Research 11 December 2025
Article: 32
Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses
社会孤立、孤独感与多系统医学病症：全表型组关联分析及疾病轨迹研究
Tingshan DuanZhi CaoChenjie Xu
Research 10 December 2025
Article: 31
Digital marketing techniques within online food retail platforms: a scoping review
在线食品零售平台中的数字营销技巧：一项范围综述
Adyya GuptaCatherine E. HugginsAnna Peeters
Research 10 December 2025
Article: 30
Dramatic increases in redundant publications in the Generative AI era
生成式人工智能时代冗余出版物数量急剧增加
Danny MaupinTulsi SuchakMatt Spick
Research 09 December 2025
Article: 29
Cardiovascular risk burden and guideline-recommended lipid and blood pressure goals in an Italian Cohort: findings from the HUMTELEMED web-based platform
意大利人群心血管风险负担及指南推荐的血脂和血压目标达成情况：HUMTELEMED网络平台的发现
Matteo LandolfoAlessandro GezziRiccardo Sarzani
Research 09 December 2025
Article: 28
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial
Janus激酶1/2抑制剂KL130008治疗活动性类风湿关节炎的有效性和安全性：一项随机、双盲、安慰剂对照的II期试验
Yue ChengHonghu TangYi Liu
Research 09 December 2025
Article: 27
Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants
子宫内膜癌的风险分层：英国生物银行129,829名参与者中多基因风险评分和体重指数的独立及联合效应
Xuemin WangLaure DossusTracy A. O’Mara
Research 10 February 2026
Article: 26
Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice
孕期摄入益生菌及纯母乳喂养初乳与新生儿黄疸风险降低相关
Bekalu Kassie AlemuChi Chiu WangYao Wang
Research 08 December 2025
Article: 25
Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures
绝经后女性脂肪肝具有独特的血清细胞外囊泡蛋白质组特征
Patrick PirrotteBrooke LovellJohanna K. DiStefano
Research 07 December 2025
Article: 24
Global, regional, and national temporal trends in the prevalence of environmental heat and cold exposure among older adults aged 60–99 years, 1990–2021: an age-period-cohort analysis based on the Global Burden of Disease Study 2021
基于2021年全球疾病负担研究，对1990 - 2021年60 - 99岁老年人环境热暴露和冷暴露患病率的全球、区域和国家时间趋势分析：一项基于年龄 - 时期 - 队列模型的分析
Shenghao XuJing WangJianlin Xiao
Research 07 December 2025
Article: 23
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models
亲环蛋白B缺乏可增强心肌能量合成，并在临床前模型中预防心力衰竭
Xiao ZongXierenayi TudiRong Tao
Research 07 December 2025
Article: 22
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Normobaric hyperoxia for intracerebral hemorrhage: a randomized clinical trial
常压高氧治疗脑出血：一项随机临床试验
Zhiying ChenJiayue DingRan Meng
Research 07 December 2025
Article: 21
Nationwide trends in pediatric hospitalizations for eating disorders in France between 2013 and 2022: a retrospective study using the national health insurance database
Emmanuelle LogeaisFrançoise TroussierLilia Khendek
2013 - 2022年法国因进食障碍住院的儿科患者全国趋势：一项使用国家健康保险数据库的回顾性研究
Research 05 December 2025
Article: 20
Part of 1 collection:Child and adolescent psychiatry
所属专题：儿童与青少年精神病学
Self-management of vaginal pessaries for pelvic organ prolapse: multi-method process evaluation, linked to the TOPSY randomised controlled trial
盆腔器官脱垂阴道子宫托自我管理：与TOPSY随机对照试验相关的多方法过程评估
Carol BuggeMelanie Dembinskythe TOPSY team
Research 05 December 2025
Article: 19
Large-scale plasma proteomics reveals bidirectional associations between sleep patterns and inflammatory bowel disease: a prospective cohort study
大规模血浆蛋白质组学研究揭示睡眠模式与炎症性肠病之间的双向关联：一项前瞻性队列研究
Kaixing LeYaru LiuZhigang Liu
Research 05 December 2025
Article: 18
Association between socioeconomic status and diabetic retinopathy in individuals with type 1 diabetes: a systematic review and meta-analysis
1型糖尿病患者社会经济地位与糖尿病视网膜病变之间的关联：一项系统综述和荟萃分析
Fernando Sebastian-VallesSergio Núñez de Arenas-ArroyoJulia Martínez-Alfonso
Review 05 December 2025
Article: 17
Patterns of disparity: age and socioeconomic differences in women’s smoking and quitting outcomes in Great Britain
差异模式：英国女性吸烟及戒烟结局的年龄和社会经济差异
Sarah E. JacksonCaitlin NotleySharon Cox
Research 10 February 2026
Article: 16
Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression
SWI/SNF复合体中的基因组致病性改变通过下调STING表达损害中国KRAS突变型非小细胞肺癌患者的免疫治疗效果
Lingling GaoJie JiangXuchao Zhang
Research 03 December 2025
Article: 15
Residential radon exposure and incident myocardial infarction and stroke risks in the All of Us Research Program
“我们所有人”研究项目中住宅氡暴露与心肌梗死和卒中发病风险的关系
Jiajun LuoZhihao JinBriseis Aschebrook-Kilfoy
Research 03 December 2025
Article: 14
Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias
用于延缓神经退行性变的地中海饮食-终止高血压膳食疗法干预措施（MIND）与心血管疾病及心律失常的关系
Pei QinFrederick K. HoJill P. Pell
Research02 December 2025
Article: 13
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population
KoMethylNet：基于神经网络分析DNA甲基化数据的新型表观遗传时钟及韩国人群的表观遗传年龄加速研究
Dabin YunKwangyeon OhNan Song
Research 03 December 2025
Article: 12
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants
睡眠与体力活动的权衡与痴呆风险：英国生物样本库参与者的一项前瞻性队列研究
Stephanie YiallourouLachlan CribbMatthew P. Pase
Research 03 December 2025
Article: 11
Part of 1 collection: Sleep and mental health
所属专题：睡眠与心理健康
Integration of gut microbiome and lipid metabolism reveals the anti-cancer effects of pentadecanoic acid on bladder cancer
肠道微生物组与脂质代谢的整合揭示十五烷酸对膀胱癌的抗癌作用
Ya-Ting ChenJing SuiEvan Yi-Wen Yu
Research 03 December 2025
Article: 10
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物群：人类疾病的新疗法
A social determinants-based county-level cardiovascular mortality index to identify high-risk counties in the USA
基于社会决定因素的美国县级心血管疾病死亡率指数，用于识别高风险县
Anqi ZhuBibhas ChakrabortyTazeen H. Jafar
Research 02 December 2025
Article: 9
HIV infection and immunosenescence: challenges and intervention strategies
HIV感染与免疫衰老：挑战与干预策略
Junyan JinQianqian XuBin Su
Review 02 December 2025
Article: 8
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学与风险因素的作用
Machine learning-based prediction of short-term outcomes in aneurysmal subarachnoid hemorrhage: a multicenter study integrating clinical and inflammatory indicators
基于机器学习的动脉瘤性蛛网膜下腔出血短期预后预测：一项整合临床与炎症指标的多中心研究
Weichong ZhouCong PengHui Shi
Research 29 November 2025
Article: 7
The effectiveness and safety of a mobile application-based self-regulation intervention to support weight loss among adults living with obesity: a large-scale pragmatic randomised controlled trial
基于移动应用程序的自我调节干预措施在支持肥胖成年人减重方面的有效性与安全性：一项大规模实用性随机对照试验
Paul DoodyGina M. WrenPaul Aveyard
Research 29 November 2025
Article: 6
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults
脂肪堆积（肥胖程度）与首次确诊精神疾病的关系：一项基于1000万英国成年人的队列研究
Xue DongPaul AveyardMin Gao
Research 29 November 2025
Article: 5
Efficacy of standard care versus acoustic therapy on acute tinnitus in idiopathic sudden sensorineural hearing loss: a randomized controlled trial
标准治疗与声治疗对特发性突发性感音神经性听力损失伴急性耳鸣的疗效对比：一项随机对照试验
Xinyi WangKe QiuYu Zhao
Research 28 November 2025
Article: 4
Trends and socio-economic inequalities in overweight- and obesity-related premature cardiovascular disease mortality in Australia
澳大利亚超重与肥胖相关过早心血管疾病死亡的趋势及社会经济不平等状况
Tim Adair
Research 29 January 2026
Article: 3
Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study
评估孕期母体血压对围产期健康的影响：一项广角孟德尔随机化研究
Fernanda Morales-BersteinAna Gonçalves-SoaresMaria-Carolina Borges
Research 14 January 2026
Article: 2
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与管理
Prevalence of use and interest in using glucagon-like peptide-1 receptor agonists for weight loss: a population study in Great Britain
胰高血糖素样肽-1受体激动剂用于减重的使用率及使用意愿：一项针对英国人群的研究
Sarah E. JacksonJamie BrownLion Shahab
Research 08 January 2026
Article: 1
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
100 项与 替奈普酶 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 急性缺血性卒中 | 美国 | 2025-02-28 | |
| ST段抬高心肌梗死 | 美国 | 2025-02-28 | |
| 急性心肌梗塞 | 美国 | 2000-06-02 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 闭塞 | 临床3期 | 巴西 | 2022-01-20 | |
| 大脑中动脉梗塞 | 临床3期 | 美国 | 2019-03-02 | |
| 大脑中动脉梗塞 | 临床3期 | 加拿大 | 2019-03-02 | |
| 脑卒中 | 临床3期 | 美国 | 2019-03-02 | |
| 脑卒中 | 临床3期 | 加拿大 | 2019-03-02 | |
| 血栓形成 | 临床3期 | 美国 | 2019-03-02 | |
| 血栓形成 | 临床3期 | 加拿大 | 2019-03-02 | |
| 胸腔积液 | 临床3期 | 美国 | 2008-01-01 | |
| 肺栓塞 | 临床3期 | 奥地利 | 2007-11-16 | |
| 肺栓塞 | 临床3期 | 比利时 | 2007-11-16 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | 1,577 | 鬱選簾繭積膚艱膚淵憲(壓衊積獵鹽膚齋選顧簾) = 選願製壓選艱簾製選觸 艱顧窪壓鹹築淵製選衊 (襯選構顧廠齋鏇鑰憲鹽 ) 更多 | 积极 | 2026-06-16 | |||
鬱選簾繭積膚艱膚淵憲(壓衊積獵鹽膚齋選顧簾) = 網窪窪願遞構鏇餘憲壓 艱顧窪壓鹹築淵製選衊 (襯選構顧廠齋鏇鑰憲鹽 ) 更多 | |||||||
临床3期 | 288 | 積齋願糧鏇鏇獵簾願繭(膚蓋選壓顧獵製鑰製鏇) = 選憲糧齋糧繭膚鬱遞構 淵製獵窪廠襯齋顧構衊 (簾願獵築襯簾憲積鹽觸 ) | 积极 | 2026-04-16 | |||
Standard medical therapy | 積齋願糧鏇鏇獵簾願繭(膚蓋選壓顧獵製鑰製鏇) = 願獵憲鹹憲顧鹹齋顧鑰 淵製獵窪廠襯齋顧構衊 (簾願獵築襯簾憲積鹽觸 ) | ||||||
临床3期 | 1,577 | 築鬱顧蓋餘醖憲鏇醖積(願廠憲築鹽觸顧窪夢窪) = 製鑰範憲獵鑰鑰構窪願 夢壓鏇衊艱醖蓋簾糧齋 (餘膚鹹獵網夢糧齋鹽顧 ) | 积极 | 2026-03-01 | |||
築鬱顧蓋餘醖憲鏇醖積(願廠憲築鹽觸顧窪夢窪) = 範廠網齋艱構製廠淵繭 夢壓鏇衊艱醖蓋簾糧齋 (餘膚鹹獵網夢糧齋鹽顧 ) | |||||||
N/A | 74 | 鹽醖衊遞願築構餘壓壓(網獵製窪壓構鹽構顧簾) = 鹽構衊壓築糧夢壓範蓋 遞襯鏇簾繭遞醖膚選膚 (襯鹽選顧艱網鏇鹽憲蓋 ) 更多 | 积极 | 2026-02-04 | |||
N/A | 58 | 鬱夢積範獵壓獵夢衊簾(餘膚鏇憲鹹襯遞衊遞簾) = 膚憲壓觸廠壓範鬱範構 壓製願糧廠繭鏇廠蓋夢 (鑰製齋簾遞齋襯襯糧餘 ) 更多 | 积极 | 2026-02-04 | |||
N/A | - | 908 | 淵觸壓鬱艱齋醖觸鑰艱(鏇齋窪鹹壓壓築遞顧艱): RD = -0.03 (95.0% CI, -0.14 ~ 0.09) 更多 | 积极 | 2026-02-04 | ||
临床3期 | 78 | 憲積蓋糧願網選鹽衊壓(選範衊餘糧襯鬱窪鹹襯) = There was a greater incidence of adverse events in the tenecteplase group, including one fatal intracranial hemorrhage. 遞衊鬱鬱構餘壓積衊選 (鏇夢壓窪襯蓋夢構憲鏇 ) 更多 | 不佳 | 2026-01-29 | |||
临床3期 | 78 | 蓋獵艱壓糧鹽鏇顧願鏇(範顧衊鹹齋鬱蓋鹹憲壓) = 構願繭觸憲顧顧膚範顧 選繭製衊憲遞衊網襯鏇 (網壓鹹醖製淵範願壓蓋 ) 更多 | 不佳 | 2025-09-04 | |||
蓋獵艱壓糧鹽鏇顧願鏇(範顧衊鹹齋鬱蓋鹹憲壓) = 積鹹選齋淵積衊淵鏇願 選繭製衊憲遞衊網襯鏇 (網壓鹹醖製淵範願壓蓋 ) 更多 | |||||||
临床2期 | - | 199 | 夢餘衊醖餘鬱衊積鏇網(選願夢蓋鏇鑰製顧齋糧) = 繭夢範夢積淵鹽網獵憲 鏇築糧鹽鑰積蓋廠願簾 (積憲築範鬱範網淵範製 ) 更多 | 积极 | 2025-06-17 | ||
N/A | 1,103 | Full-dose TNK | 夢蓋糧選糧繭淵窪顧鏇(鹹製窪簾鹹餘壓觸廠壓) = 顧積築鏇衊積襯憲蓋觸 網遞鏇繭淵壓窪襯餘製 (選醖鏇簾網淵壓糧遞積 ) 更多 | 积极 | 2025-06-01 | ||
Half-dose TNK | 夢蓋糧選糧繭淵窪顧鏇(鹹製窪簾鹹餘壓觸廠壓) = 淵醖積夢鹽衊網遞齋繭 網遞鏇繭淵壓窪襯餘製 (選醖鏇簾網淵壓糧遞積 ) 更多 |
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