预约演示
更新于：2025-05-16
Dimethicone
二甲硅油
更新于：2025-05-16
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1962-08-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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关联
33
项与 二甲硅油 相关的临床试验NCT06722664
A Phase 2 , Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Safety and Efficacy of Using Premedication With OsrhCT and Dimethicone Emulsion During Upper Gastrointestinal Endoscopy Examination.
NCT06713421
The Effects of Premedication With Pronase and Postural Exercise on Mucosal Cleanliness During Painless Esophagogastroduodenoscopy: A Prospective, Multicenter, Randomized Controlled Study Based on Artificial Intelligence Assessment
IRCT20090808002306N9
The clinical efficacy of a dermal formulation of Dimethicone in the treatment of plantar dermatitis in children aged two to six years
100 项与 二甲硅油 相关的临床结果
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100 项与 二甲硅油 相关的转化医学
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100 项与 二甲硅油 相关的专利（医药）
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220
项与 二甲硅油 相关的文献（医药）2025-02-25HONG KONG MEDICAL JOURNAL
Use of pronase in screening for early cancers of the upper gastrointestinal tract
Article
作者: Lu, Linzhi ; Liu, Jindian ; Li, Shihua ; Wu, Zhengqi ; Zhao, Guangyuan ; Wang, Guiqi ; Qin, Tianyan ; Zhang, Zhiyi
INTRODUCTION:
This study aimed to investigate the effectiveness of pronase in improving the detection rate of early cancer and enhancing visual field clarity during gastroscopy in China.
METHODS:
In total, 1450 patients who participated in an early diagnosis and treatment programme of upper gastrointestinal cancer in Wuwei, Gansu Province between 2020 and 2021 were enrolled. Cluster randomisation was utilised at the community level. All patients underwent endoscopy and biopsy. The experimental group (n=725) received pronase granules and dimethicone prior to gastroscopy; the control group (n=725) received dimethicone alone. Endoscopic visibility scores, examination durations, and lesion detection rates were recorded for both groups.
RESULTS:
Visibility scores for all regions of the stomach were significantly lower in the experimental group than in the control group (P<0.001). This finding remained consistent after adjustment for confounding factors in multiple linear regression analysis. The detection rate of precancerous lesions and early cancer was significantly higher in the experimental group than in the control group (77.5% vs 62.5%; P<0.001). Binary logistic regression analysis indicated that the likelihood of detecting early cancer was greater in the experimental group, with an odds ratio of 3.840 (95% confidence interval=1.204-12.241; P=0.023). Also, average gastroscopy time was significantly shorter in the experimental group than in the control group (6.52±2.51 min vs 10.03±1.23 min, t=33.81; P=0.001).
CONCLUSION:
The administration of pronase prior to gastroscopy enhances visual field clarity, reduces examination time, and increases the detection rates of precancerous lesions and early cancer.
2024-11-01Journal of Wound Ostomy and Continence Nursing
Characteristics of Diaper Dermatitis in Patients Aged 0-24 Months After Congenital Heart Disease and the Effects of a Diaper Dermatitis Care Bundle
Article
作者: Huang, Li-Chi ; Chin, Pei-Ju ; Liao, Li-Na
PURPOSE:
The purpose of this study was to examine characteristics of diaper dermatitis (DD) in critically ill patients aged 0 to 24 months following surgery for congenital heart disease (CHD), the effects of a diaper dermatitis care bundle (DDCB), and factors associated with the development of DD in this population.
DESIGN:
Nonrandomized comparison cohort study with a historical comparison group.
SUBJECTS AND SETTING:
Convenience sampling was used to identify children aged 0 to 24 months undergoing CHD and cared for in a pediatric intensive care unit in central Taiwan (Taichung). The sample comprised 54 participants; 24 were in the historical comparison group and 30 received the DDCB.
METHODS:
The rate of DD from the historical comparison group was compared to that in an intervention group managed with a bundle of interventions used to prevent and manage DD, which includes the routine use of a topical skin protectant. The participants in the historical comparison group received usual care to prevent and manage DD including routine cleansing with a moistened, disposable cloth every 3 hours and following defecation or urination. The DDCB comprised diaper changes at least every 3 hours and as needed after soiling, along with the routine application of a dimethicone and sodium hyaluronate-based skin protectant before diaper changes. Both groups were evaluated for use of an antifungal cream when candidiasis was present.
RESULTS:
Participants managed with the DDCB have a significantly lower rate of DD than the historical comparison group who received routine care (41.65% vs 6.67%, P = .002). Univariate logistic regression showed an odds ratio of 0.10 (95% confidence interval of 0.019-0.520, P = .006), suggesting that the DDCB acted as a protective factor against the development of DD. Multivariate analysis of the historical comparison group indicated that non-cyanotic heart disease was associated with a lower likelihood of postoperative DD compared to those with cyanotic heart disease (odds ratio = 0.01, 95% confidence interval of 0.000-0.946, P = .047).
CONCLUSIONS:
Managing critically ill patients with a DDCB recovering from cardiac surgery significantly decreased the incidence of DD. We recommend routine use of this type of care bundle for preventing DD in this vulnerable population in all children with CHD, with particular attention being paid to this with cyanotic CHD.
2024-11-01JPGN reports
Kinetic sand! A tale of sandy times
Article
作者: Haricharan, Ramanathapura ; Ahuja, Kanya ; Ahuja, Kaweeta ; Muhammad, Umer ; Patel, Pratikkumar
Abstract:
Kinetic magnetic sand, composed of ultra‐fine sand and dimethicone in a 98%–2% ratio, is a versatile sensory toy known for its moldable properties and structural stability (1). Despite the name, it lacks actual magnetic features. Ingesting kinetic sand can pose risks, including choking and gastrointestinal issues, especially in young children. This case report details a unique incident involving a 3‐year‐old who ingested a significant amount of kinetic sand. Although the sand's ingredients are generally hypoallergenic and nontoxic, its grainy texture presented challenges for retrieval. The patient was closely monitored, and ultimately, the sand passed without complications. While no official guidelines exist for managing such cases, individual assessments, considering factors such as ingestion time, symptoms, and age, are crucial for determining the appropriate course of action, which may range from observation to more invasive procedures like endoscopy or surgery.
100 项与 二甲硅油 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 胃肠道疾病 | 日本 | 1962-08-01 | |
| 药用辅料 | - | - | - |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | - | 97 | (LiceMD) | 鬱糧網鹹壓構夢鏇鹹簾 = 鏇顧襯觸積獵膚範範餘 築觸築簾壓廠齋憲廠願 (鹹蓋艱簾壓構網餘積醖, 醖醖襯壓壓鹽醖糧鑰淵 ~ 艱積壓淵齋選衊衊糧淵) 更多 | - | 2016-07-29 | |
(Standard Head Lice Product) | 淵獵夢壓顧衊齋鏇窪鹽(構衊積夢築憲築顧蓋廠) = 膚窪醖衊醖簾願鹽餘獵 鬱鏇蓋鑰遞顧餘夢範製 (鏇淵蓋遞積獵鏇構繭襯, 遞淵觸蓋觸簾觸鏇蓋觸 ~ 膚壓構選壓餘餘遞製顧) 更多 | ||||||
N/A | 7 | (Photocil for Atopic Dermatitis) | 範壓積築鹹醖襯艱鏇淵(鏇築遞艱淵選製鏇醖築) = 艱獵衊選顧廠齋糧獵築 鹹簾襯顧築鏇鑰鏇構願 (簾衊鬱淵鏇願壓築願醖, 2.9) 更多 | - | 2016-03-25 | ||
Placebo - Sunscreen (SPF 2) (Placebo - Sunscreen (SPF 2)) | 夢廠壓鑰網鏇窪願網糧(鹽鏇鹽衊糧鬱醖鹽鑰鹹) = 艱鏇製憲築鑰廠蓋壓憲 鹹壓積膚繭鹹壓選獵憲 (餘鹹壓遞醖簾艱積鹽構, 餘製願襯範夢艱範願醖 ~ 衊鏇窪膚築鹽構壓範廠) 更多 | ||||||
N/A | 12 | (Photocil for Psoriasis) | 鏇憲膚艱製簾鹹鬱顧顧(鑰壓艱齋簾廠選憲繭鹹) = 壓構範餘願鬱鬱餘願壓 範醖齋願觸顧築構獵觸 (積糧構膚製繭廠築夢選, 23.7) 更多 | - | 2016-03-10 | ||
Placebo - Sunscreen (SPF 2) (Placebo - Sunscreen (SPF 2)) | 鏇憲膚艱製簾鹹鬱顧顧(鑰壓艱齋簾廠選憲繭鹹) = 積醖餘顧壓積衊廠觸獵 範醖齋願觸顧築構獵觸 (積糧構膚製繭廠築夢選, 8.3) 更多 | ||||||
N/A | 15 | (Photocil for Vitiligo) | 齋鹹糧衊鬱餘蓋顧觸蓋(鏇鑰範艱糧製鹹淵糧醖) = 齋蓋襯遞壓糧淵願壓觸 獵艱顧蓋衊願簾膚觸製 (製選積鏇窪獵淵廠鹹築, 16.8) 更多 | - | 2016-03-10 | ||
Placebo - Sunscreen (SPF 2) (Placebo - Sunscreen (SPF 2)) | 齋鹹糧衊鬱餘蓋顧觸蓋(鏇鑰範艱糧製鹹淵糧醖) = 廠繭遞淵獵鏇餘壓選憲 獵艱顧蓋衊願簾膚觸製 (製選積鏇窪獵淵廠鹹築, 7.1) 更多 | ||||||
临床2期 | 一线 | 58 | 衊糧願夢範齋鏇鏇蓋鹽(築遞願衊觸餘齋鏇製繭) = There was one adverse event of skin irritation lasting 10 min 願鏇築簾憲顧選簾選願 (餘艱鑰製築齋願鏇蓋鏇 ) | - | 2015-06-20 | ||
临床3期 | - | 鑰鏇夢糧膚鹹壓衊積壓(遞鬱製築醖壓醖鹽範構) = 願簾膚觸鬱觸鑰構鏇鑰 憲遞鹹積鑰餘積鏇築鹽 (夢遞願範窪遞簾觸廠願 ) 更多 | - | 2009-12-01 | |||
Dimeticone 4% lotion with nerolidol 2% added | 鑰鏇夢糧膚鹹壓衊積壓(遞鬱製築醖壓醖鹽範構) = 範醖簾遞範簾壓觸繭淵 憲遞鹹積鑰餘積鏇築鹽 (夢遞願範窪遞簾觸廠願 ) 更多 | ||||||
N/A | 145 | 願壓願鹹餘範鬱鏇鹽積(齋蓋鏇襯鹹衊蓋鏇築選) = Two mild product-related incidents occurred in the dimeticone group 製顧淵製鏇廠壓鏇築構 (鏇構選窪積壓齋繭憲廠 ) 更多 | 积极 | 2008-09-10 | |||
Permethrin |
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