更新于：2024-12-09

Permethrin

扑灭司林

更新于：2024-12-09

概要

概要

基本信息

药物类型

小分子化药

别名

(3-Phenoxyphenyl)methyl (±)-cis,trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate、3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropane carboxylic acid, (3-phenoxyphenyl) methyl ester、Nedax

+ [7]

靶点

Nav1.1

作用机制

Nav1.1阻滞剂(I型钠通道蛋白α亚基阻滞剂)

治疗领域

感染皮肤和肌肉骨骼疾病

在研适应症

虱病

非在研适应症-

原研机构

GSK Plc

在研机构

Medtech Products, Inc.

非在研机构

GSK Plc

最高研发阶段批准上市

首次获批日期

美国 (1986-03-31),

虱病

最高研发阶段(中国)-

特殊审评-

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结构

分子式C21H20Cl2O3

InChIKeyRLLPVAHGXHCWKJ-UHFFFAOYSA-N

CAS号52645-53-1

关联

项与扑灭司林相关的临床试验

CTRI/2024/10/075991 / Not yet recruitingN/A

A Randomized, Double-Blind, Multi-Center, Parallel Study to Evaluate the Bioequivalenceusing Clinical Endpoint of Permethrin Cream, 5 percentage of KLM Laboratories Pvt. Ltd., India toPermethrin Cream, 5 percentage of Padagis Israel Pharmaceuticals Ltd in Subjects with scabies. - nil

开始日期2024-11-18

申办/合作机构-

IRCT20110420006243N5 / Recruiting临床3期IIT

Comparison effect of permethrin shampoo to permethrin shampoo with vinegar in the treatment of head lice in children aged 6-13 years

开始日期2024-09-22

申办/合作机构

Shahed University

CTRI/2024/09/073345 / Not yet recruiting临床2/3期

Efficacy of Tila Qatran Madani with Shibb Yamani versus Permethrin in Jarab (Scabies) - A Randomized Control Clinical Trial - Nil

开始日期2024-09-09

申办/合作机构

National Institute of Unani Medicine

100 项与扑灭司林相关的临床结果

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100 项与扑灭司林相关的转化医学

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100 项与扑灭司林相关的专利（医药）

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4,057

项与扑灭司林相关的文献（医药）

2025-02-01·NEUROPHARMACOLOGY

Neuroprotection by 4R-cembranoid against Gulf War Illness-related Chemicals is mediated by ERK, PI3K, and CaMKII pathways

Article

作者: Roche Lima, Abiel ; Alicia, Sorangely Vázquez ; Ferchmin, Pedro A ; Vázquez Alicia, Sorangely ; Rivera-Moctezuma, Félix G. ; Rivera-Moctezuma, Félix G ; Pérez, Dinely ; Sabeva, Nadezhda ; Tosado-Rodríguez, Eduardo L. ; Ferchmin, Pedro A. ; Marrero Valentín, José L ; Tosado-Rodríguez, Eduardo L ; Marrero Valentín, José L.

Gulf War Illness (GWI) has been consistently linked to exposure to pyridostigmine (PB), N,N-Diethyl-meta-toluamide (DEET), permethrin (PER), and traces of sarin. In this study, diisopropylfluorophosphate (DFP, sarin surrogate) and the GWI-related chemicals were found to reduce the number of functionally active neurons in rat hippocampal slices. These findings confirm a link between GWI neurotoxicants and N-Methyl-D-Aspartate (NMDA)-mediated excitotoxicity, which was successfully reversed by Edelfosine (a phospholipase Cβ (PLCβ3) inhibitor) and Flupirtine (a Kv7 channel agonist). To test whether 4R-cembranoid (4R), a nicotinic α7 acetylcholinesterase receptor (α7AChR) modulator known for its neuroprotective properties, can restore hippocampal neurons from glutamate-induced neurotoxicity, we exposed rat hippocampal slices with DFP for 10 min followed by 60 min treatment with 4R. We investigated the 4R mechanisms of neuroprotection after preincubation with LY294002, PD98059, and KN-62. The inhibition of the phosphatidylinositol 3-kinase (PI3K), mitogen-activated protein kinase (MEK1/2), and calcium/calmodulin-dependent protein kinase (CaMKII) abrogated the protective effect of 4R against DFP-induced neurotoxicity. In separate experiments, after incubation with DFP, followed by 4R for 1 h, cellular extracts were prepared for Western blotting of phospho-Akt, phospho-GSK3β, phosphorylated extracellular signal-regulated kinase (ERK)1/2, CaMKII and cAMP response element-binding protein (CREB). Our results show that DFP induces neuronal dysfunction by dephosphorylation, while 4R restores the phosphorylation of Akt, GSK3, ERK1/2, CREB, and CaMKII. Moreover, our proteomics analysis supported the notion that 4R activates additional signaling pathways related to enhancing neuronal signaling, synaptic plasticity, and apoptotic inhibition to promote cell survival against DFP, offering biomarkers for developing treatment against GWI.

2024-12-01·ENVIRONMENTAL RESEARCH

Characterization of pesticide exposures and their associations with asthma morbidity in a predominantly low-income urban pediatric cohort in Baltimore City

Article

作者: Quirós-Alcalá, Lesliam ; Meeker, John D. ; Matsui, Elizabeth C ; Tore, Grant ; Matsui, Elizabeth C. ; Peng, Roger D. ; Fandiño-Del-Rio, Magdalena ; Peng, Roger D ; Meeker, John D

BACKGROUND:

Pesticides may impact respiratory health, yet evidence of their impact on pediatric asthma morbidity is limited, particularly among urban children.

OBJECTIVE:

To characterize pesticide biomarker concentrations and evaluate their associations with pediatric asthma morbidity among predominantly low-income, Black children in Baltimore City, USA.

METHODS:

We measured urinary concentrations of 10 biomarkers for pyrethroid insecticides (cyfluthrin:4F-3PBA, permethrin:3PBA), organophosphate insecticides (chlorpyrifos:TCPY, malathion:MDA, parathion:PNP, diazinon:IMPY), and herbicides (glyphosate:AMPA, GPS; 2,4-dicholorphenoxyacetic acid:2,4-D; 2,4,5-tricholorphenoxyacetic acid:2,4,5-T) among 148 children (5-17 years) with established asthma. Urine samples and asthma morbidity measures (asthma symptoms, healthcare utilization, lung function and inflammation) were collected every three months for a year. Generalized estimating equations were used to examine associations between pesticide biomarker concentrations and asthma morbidity measures, controlling for age, sex, race, caregiver education, season, and environmental tobacco smoke. In sensitivity analyses, we assessed the robustness of our results after accounting for environmental co-exposures.

RESULTS:

Frequently detected (≥90% detection) pesticide biomarker concentrations (IMPY, 3PBA, PNP, TCPY, AMPA, GPS) varied considerably within children over the follow-up period (intraclass correlation coefficients: 0.1-0.2). Consistent positive significant associations were observed between the chlorpyrifos biomarker, TCPY, and asthma symptoms. Urinary concentrations of TCPY were associated with increased odds of coughing, wheezing, or chest tightness (adjusted Odds Ratio, aOR, TCPY:1.60, 95% Confidence Interval, CI:1.17-2.18). Urinary concentrations of TCPY were also associated with maximal symptom days (aOR:1.38, CI:1.02-1.86), exercise-related symptoms (aOR:1.63, CI:1.09-2.44), and hospitalizations for asthma (aOR:2.84, CI:1.08-7.43). We did not observe consistent evidence of associations between the pesticide exposures assessed and lung function or inflammation measures.

CONCLUSION:

Among predominantly Black children with asthma, we found evidence that chlorpyrifos is associated with asthma morbidity. Further research is needed to assess the contribution of pesticide exposures to pediatric respiratory health and characterize exposure sources among vulnerable populations to inform targeted interventions against potentially harmful pesticide exposures.

2024-12-01·JOURNAL OF HAZARDOUS MATERIALS

Do pyrethroid pesticide residues in Chinese mitten crab aquaculture areas have an impact on the ecological environment? ——A case study of Yangcheng Lake

Article

作者: Xie, Yufeng ; Chen, Shihui ; Gu, Mingyue ; Jiang, Jinlin ; Liao, Jianhua ; Long, Tao

Pyrethroid pesticides are widely used in agriculture, aquaculture, and daily life in China, leading to concerns about their environmental residues. However, there is limited information available regarding the compositional distribution, bioaccumulation, and associated health and environmental risks of pyrethroids in the aquaculture areas of Eastern China. This study investigated the residues, distribution, and risk assessment of pyrethroids including deltamethrin, permethrin, fenvalerate, cypermethrin and bifenthrin in Yangcheng Lake using solid-phase extraction and gas chromatography-tandem mass spectrometry. The risk assessment of water, sediment, and aquatic products of Yangcheng Lake was conducted using various evaluation methods. The results revealed that pyrethroids were found at higher levels in both water and sediment in Yangcheng Lake with some seasonal variations observed in their distribution patterns. Compared with other watersheds in China, typical aquaculture areas of the Yangtze River Delta showed higher detection rates and quantities of pyrethroid pesticides. Ecological risk assessments indicated high risks to the environment from all five tested pyrethroids at Yangcheng Lake; deltamethrin posed the highest risk among them. Dietary assessment results showed no risks associated with aquatic products from Yangcheng Lake but drinking water at certain sites presented unacceptable health risks.

项与扑灭司林相关的新闻（医药）

2024-08-13

·drugs

Pesticide Exposure Tied to Increased Risk for Stillbirth

TUESDAY, Aug. 13, 2024 -- Pesticide exposures during preconception and the first trimester may be associated with stillbirth, according to a study published online July 16 in the American Journal of Epidemiology . Melissa A. Furlong, Ph.D., from the University of Arizona College of Public Health in Tucson, and colleagues linked Arizona pesticide use records (27 types) with birth certificates (2006 to 2020) to estimate associations between living within 500 m of any application site and stillbirth. The researchers found that during 90 days preconception, any exposures to pesticides were associated with stillbirth, including cyfluthrin (relative risk [RR], 1.97), zeta-cypermethrin (RR, 1.81), organophosphates as a class (RR, 1.60), malathion (RR, 2.02), carbaryl (RR, 6.39), and propamocarb hydrochloride (RR, 7.72). During the first trimester, fenpropathrin (RR, 4.36), permethrin (RR, 1.57), organophosphates as a class (RR, 1.50), acephate (RR, 2.31), and formetanate hydrochloride (RR, 7.22) were associated with stillbirth. "These findings underscore the importance of considering individual pesticides rather than just the overall pesticide class, as specific chemical compounds may pose unique risks," Furlong said in a statement. "It also highlights the potential for prepregnancy exposures to affect reproductive outcomes." One author disclosed ties to pesticide registrants unrelated to the research.

2023-12-27

·生物谷

Molecular Cell | 蒋辉实验室揭示线粒体自噬的感知和抑制因子PPTC7及其对线粒体数量的调控作用

线粒体自噬(mitophagy)是重要的线粒体质量及数量调控机制, 与发育、癌症、衰老和神经退行性病变等生理病理状况高度相关。现已知两类哺乳动物mitophagy通路：由PINK1-Parkin介导的泛素依赖途径，以及由BNIP3, NIX和FUNDC1等介导的受体依赖途径。然而，人们对mitophagy调控机制及其生理病理意义仍有待探索。突出的表现是，缺失已知mitophagy通路的小鼠(如Pink1-/-、Parkin-/-、Bnip3-/-等)表型微弱，与普遍认知的mitophagy重要性有明显差距。2023年12月26日，北京生命科学研究所/清华大学生物医学交叉研究院蒋辉实验室在Molecular Cell在线发表了题为"A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass"的论文。该论文发现了一个感知并抑制mitophagy的因子PPTC7，阐明了PPTC7调控mitophagy的分子机制并揭示其对线粒体数量和代谢稳态的调控作用。作为监控mitophagy水平的关键因子，PPTC7感知mitophagy受体BNIP3和NIX的蛋白水平，进而起始BNIP3/NIX-PPTC7-SCFFBXL4完整复合物的组装，促进SCFFBXL4泛素化和降解BNIP3和NIX，从而抑制mitophagy。该通路对维持细胞线粒体数量、代谢平衡、和个体存活至关重要。01FBXL4介导的mitophagy调控与退行性疾病MTDPS13蒋辉实验室长期从事线粒体蛋白稳态调控机制研究，之前报道了一个线粒体外膜复合物UBXD8-VCP介导BNIP3降解，从而抑制mitophagy(链接：EMBO Reports | 蒋辉实验室揭示UBXD8调控凋亡和线粒体自噬的分子机制)。为进一步发掘mitophagy调控机制，研究生曹钰通过靶向线粒体的遗传筛选发现多个mitophagy抑制因子，其中包括FBXL4和PPTC7(链接：EMBO Journal | 蒋辉实验室揭示线粒体自噬调控及线粒体疾病新机制)。已知FBXL4突变导致致死性退行性疾病线粒体DNA耗竭综合征13(MTDPS13)1,2，但其机理未明。作者发现FBXL4定位于线粒体外膜，与Skp1和Cullin1组成SCFFBXL4 E3泛素连接酶。SCFFBXL4通过泛素化降解BNIP3和NIX来抑制mitophagy。而病人来源的FBXL4突变抑制SCFFBXL4组装，导致BNIP3和NIX蛋白积累和mitophagy过度激活。FBXL4突变患者表现出mtDNA耗竭、线粒体数量减少、酸中毒、神经和肌肉退行性病变等严重症状。与FBXL4突变病人类似，Fbxl4-/-小鼠表现出BNIP3和NIX蛋白积累、mitophagy失控、线粒体数量减少、代谢紊乱和围产期死亡等严重表型。更重要的是，在Fbxl4-/-小鼠中敲除Bnip3或Nix可以挽救线粒体数量、恢复代谢平衡并挽救小鼠寿命。这些结果表明过度mitophagy导致的线粒体数量减少是MTDPS13的致病原因并为治疗提供了思路。02PPTC7调控FBXL4介导的BNIP3和NIX降解鉴于BNIP3和NIX强大且危险的线粒体清除能力，细胞必须牢牢控制其水平，但细胞监控并调节BNIP3和NIX降解的分子机制仍不清楚。研究生孙雨秋研究另一个筛选发现的mitophagy抑制因子PPTC7。前人研究表明PPTC7是定位于线粒体基质的磷酸酶。但令人诧异的是，与敲除FBXL4类似，敲除PPTC7同样导致BNIP3和NIX的积累和过度mitophagy；Pptc7-/-小鼠表现出mitophagy失控、线粒体数量减少和围产期死亡的表型，且该表型可以被Nix敲除所挽救(图1)。此外，PPTC7过表达可促进内源BNIP3和NIX被FBXL4降解，而FBXL4过表达则没有效果，提示PPTC7作为上游限速因子调控FBXL4介导的BNIP3和NIX降解。但是，线粒体基质蛋白PPTC7如何调控线粒体外膜上的蛋白降解？图1PPTC7缺失过度激活BNIP3和NIX依赖的mitophagy，造成线粒体数量减少和小鼠死亡。A,Pptc7 -KO升高小鼠肝脏中mitophagy受体BNIP3和NIX的蛋白水平(红框)并导致其他线粒体蛋白减少(蓝框)。B,小鼠生存曲线。03PPTC7前体通过与BNIP3/NIX直接互作，滞留在线粒体外膜通常情况下，线粒体基质蛋白的前体形式(precursor)在N端定位序列(targeting sequence)的引导下进入线粒体，并在线粒体基质切除定位序列，完成成熟过程。作者发现在野生型细胞里，PPTC7以成熟形式(mature form,切除了定位序列)存在于线粒体基质，而在FBXL4-KO细胞里，PPTC7同时具有定位于线粒体基质的成熟形式和定位于线粒体外膜的前体形式。进一步分析表明，FBXL4-KO细胞中积累的BNIP3和NIX导致PPTC7前体出现在线粒体外膜;在野生型细胞中直接过表达BNIP3或NIX也可诱导PPTC7前体出现在线粒体外膜定位。通过体外重组蛋白实验，作者发现BNIP3和NIX与PPTC7直接互作，并使用交联质谱分析了NIX-PPTC7的互作区域。在截去NIX与PPTC7的直接互作区域后，NIX无法诱导PPTC7前体的外膜定位，表明BNIP3和NIX通过与PPTC7的直接互作，将PPTC7前体定位于线粒体外膜。04弱化的PPTC7定位序列帮助PPTC7在线粒体外膜滞留有意思的是，作者发现与经典线粒体基质定位序列相比，PPTC7的定位序列长度短且引导能力差，推测该特征削弱了PPTC7前体进入线粒体基质的能力，有利于PPTC7前体被外膜BNIP3/NIX滞留。因此，研究者将PPTC7的定位序列替换成经典序列，发现它使PPTC7全部进入线粒体基质，无法被滞留在外膜，失去调节BNIP3和NIX降解的能力。05外膜PPTC7起始组装BNIP3/NIX-PPTC7-SCFFBXL4复合物那么外膜PPTC7如何促进SCFFBXL4介导的BNIP3和NIX降解呢？作者发现除与BNIP3/NIX直接互作之外，PPTC7还与SCFFBXL4复合物中的Cullin1直接互作。作者表达纯化了NIX，PPTC7，FBXL4,Cullin1-Rbx1和Skp1的重组蛋白，发现只有在所有蛋白都存在的情况下，这些蛋白才能组装成完整的NIX-PPTC7-SCFFBXL4复合物，缺少NIX，PPTC7，FBXL4任何一个组分都导致复合物散架。以上结果提供了一个mitophagy的负反馈调控模型:积累在线粒体外膜的mitophagy受体BNIP3和NIX与PPTC7前体直接互作，将其滞留在外膜，起始BNIP3/NIX-PPTC7-SCFFBXL4复合物的组装，从而泛素化和降解BNIP3和NIX，防止mitophagy过度激活(图2)。06禁食情况下，肝脏诱导PPTC7来抑制mitophagy和维持代谢稳态一个重要的问题是在负反馈调控mitophagy之外，PPTC7是否还会响应生理信号？鉴于PPTC7过表达能促进BNIP3和NIX降解，作者重点研究了生理信号对PPTC7表达的调节，发现禁食不改变骨骼肌PPTC7的表达，但在肝脏强烈诱导PPTC7。与之相对应，禁食强烈诱导骨骼肌mitophagy，但不改变肝脏mitophagy水平，作者推测肝脏mitophagy受到PPTC7上调的压制。因此，作者在小鼠肝脏敲除PPTC7，发现禁食导致缺失PPTC7的肝脏丢失大量线粒体。禁食情况下，肝脏负有重要使命-通过糖异生(gluconeogenesis)维持血糖水平。而糖异生需要线粒体提供两个重要支持：ATP和丙酮酸羧化酶(pyruvate carboxylase)。作者发现，敲除肝脏PPTC7导致禁食状态下肝脏ATP缺乏，糖异生受阻，造成严重的低血糖。因此，禁食情况下，肝脏特异上调PPTC7以压制mitophagy，从而维持线粒体数量和代谢稳态(图2)。图2 PPTC7调控mitophagy的工作模型。1. mitophagy的负反馈稳态调控。正常情况下，PPTC7表达后进入线粒体基质行使正常功能。当mitophagy受体BNIP3和NIX积累时，BNIP3/NIX将PPTC7前体滞留于外膜，起始BNIP3/NIX-PPTC7-SCFFBXL4复合物组装，从而降解BNIP3和NIX，防止mitophagy过度激活和线粒体丢失。2. 在禁食情况下，肝脏上调PPTC7以压制mitophagy，从而维持肝脏能量供应和糖异生通路活力，维持血糖水平。综上，该工作报道了一个感知和抑制mitophagy的PPTC7-SCFFBXL4通路。PPTC7作为关键调控因子，能够整合稳态维持和生理信号来调控mitophagy水平，以此维持线粒体数量和细胞代谢稳态。该通路的发现显著增进了我们对mitophagy与线粒体数量控制(mitochondrial mass control)的理解。禁食情况下，肝脏和骨骼肌对mitophagy的差异化调节及其功能研究也丰富了我们对生理情况下组织特异性mitophagy调控的认知。清华大学生物医学交叉研究院博士生孙雨秋为论文第一作者，蒋辉博士为通讯作者。该论文其他作者包括蒋辉课题组的曹钰和万华云，董梦秋实验室的阿达莱提买买提明和董梦秋博士，代谢组学中心的马燕博士和曹杨，蛋白质组中心的陈涉博士和李琳，遗传筛选中心的李祺博士和吴重阳，刘清华实验室的王濛。该研究由科技部、北京市政府和清华大学共同资助，在北京生命科学研究所完成。论文链接：https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)01014-6本文仅用于学术分享，转载请注明出处。若有侵权，请联系微信：bioonSir 删除或修改！

临床1期蛋白降解靶向嵌合体引进/卖出

2023-08-16

·BioSpace

Stada CEO Confirms Buyout Rumors, Sale Could Potentially Fetch $11B

Pictured: Businessmen shaking hands after closing a deal/iStock, Natee Meepian German generics developer Stada Arzneimittel is mulling over a potential $11 billion sale, though there are no concrete and definite plans yet, CEO Peter Goldschmidt confirmed Tuesday. Goldschmidt made the statement to German-language publication Zeit Online, which was confirmed by a Stada spokersperson to Endpoints News. “From my point of view, our owners are in an orientation phase in which initial exploratory talks are taking place. I don’t expect a decision before 2024,” Goldschmidt said, according to a translation from the spokesperson. Rumors of the potential sale first circulated earlier this month when Bloomberg, citing sources familiar with the matter, reported that Stada’s private equity owners were looking at their options for the company moving forward including a sale. Bloomberg reported that Bain Capital and Cinven had started approaching banks “to pitch for roles on a possible transaction.” If a sale does push through, Stada could go for approximately $11 billion (€10 billion) or more, according to the sources, who requested to remain anonymous. Bain and Cinven assumed ownership of Stada in 2017, when the investment firms dropped approximately $5.6 billion to buy nearly 63.9% of the drugmaker’s outstanding shares. As part of the takeover, Bain and Cinven committed to support Stada including “investment in organic growth and expansion through acquisitions,” according to Cinven’s news release at the time. According to the Stada spokesperson, Bain and Cinven are considering a sale now because “it is common for financial investors to exit after five to six years.” Also on Tuesday, Stada posted its most recent earnings report touting its “best half-year results to date” with double-digit sales and strong profit growth, which were driven by the robust performances of its consumer healthcare, specialty pharmaceuticals and generics businesses. The company’s consumer healthcare vertical, Stada’s largest strategic segment, saw several launches and line extensions which contributed to a 19% adjusted increase in sales. Recent acquisitions, including the Sanofi brands Omnivit and Ompticrom eye drops, also factored into the growth of the consumer healthcare business. Stada’s generics and specialty segments also performed well with adjusted sales advancing by 8% and 24%, respectively. In particular, the launches of the anticoagulant apixaban, the diabetes drug sitagliptin, the pain-reliever tapentadol and the anti-parasitic medicine permethrin contributed to Stada’s strong first-half results. Tristan Manalac is an independent science writer based in Metro Manila, Philippines. He can be reached at tristan@tristanmanalac.com or tristan.manalac@biospace.com.

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外链

KEGG	Wiki	ATC	Drug Bank
D05443	扑灭司林	P03AC04	DB04930

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
虱病	美国	GSK Plc	1986-03-31

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


WCD2023	N/A	疥疮	-	5% permethrin cream	顧鏇鹹網鏇憲繭夢選選(製積簾膚範衊網鏇製醖) = 齋淵遞壓範製築簾築鏇壓淵糧壓餘夢積廠鬱範 (蓋壓齋衊膚繭鑰顧齋膚 )	积极	2023-07-03
IRCT2017100936672N1 (Pubmed \| Rev Recent Clin Trials)	早期临床1期	头虱	121	Ozonated Olive Oil Topical Lotion	遞積窪鹽壓範蓋範鑰憲(膚製窪製糧餘襯鏇憲醖) = 鹽簾鹹艱繭觸壓鏇糧淵衊遞蓋鹽鬱夢鹽艱範遞 (鬱淵淵壓廠獵觸膚壓餘 )	积极	2022-02-01
NCT02978508 (CTgov)	临床3期	疥疮	140	Permethrin Cream, 5% (Permethrin Cream, 5%)	範獵選鬱積簾憲壓製蓋(築顧窪夢艱鹽衊鑰簾壓) = 蓋夢齋繭鹹觸夢艱積鏇鏇鑰鹹醖範蓋觸願廠鑰 (廠獵窪獵鑰顧衊衊襯構, 構觸網構蓋鬱範衊積製 ~ 餘憲鏇憲觸願膚鏇願蓋) 更多	-	2020-09-02
				Elimite (Elimite)	範獵選鬱積簾憲壓製蓋(築顧窪夢艱鹽衊鑰簾壓) = 製簾艱膚築積艱積衊繭鏇鑰鹹醖範蓋觸願廠鑰 (廠獵窪獵鑰顧衊衊襯構, 淵醖艱鹹獵壓網積齋築 ~ 艱窪選鹹膚糧膚願憲襯) 更多
NCT02775617 (AIM-Skin, CTgov)	临床4期	雅司病 \| 脓疱疮 \| 疥疮	1,291	Ivermectin+Azithromycin+Permethrin (Parallel Treatment)	網獵遞範鏇襯製壓齋鏇(觸憲糧積鑰壓糧壓鹽壓) = 遞網窪艱鑰網壓觸艱蓋製觸淵製觸齋衊淵繭艱 (鹹壓糧艱襯鹹餘壓醖遞, 壓鑰積憲構鏇範網獵淵 ~ 蓋襯壓蓋夢憲簾鹹膚範) 更多	-	2019-09-13
				Ivermectin+Azithromycin+Permethrin (Sequential Treatment)	網獵遞範鏇襯製壓齋鏇(觸憲糧積鑰壓糧壓鹽壓) = 積餘構廠積網壓憲築夢製觸淵製觸齋衊淵繭艱 (鹹壓糧艱襯鹹餘壓醖遞, 繭廠構淵醖範鏇範齋範 ~ 齋鑰鏇糧簾願廠築鏇膚) 更多
NCT03236168 (CTgov)	临床3期	疥疮	118	Ivermectin+Malathion Shampoo 0.5%+Permethrin 5%	衊鹽襯網鬱網鹽選觸醖(鏇遞範顧窪顧築廠艱鏇) = 艱積繭蓋積蓋築觸鏇願鬱艱淵繭壓製窪鏇糧壓 (淵顧遞窪選構構衊觸淵, 齋鏇獵壓構網築齋鏇壓 ~ 鹹衊築網簾餘製衊艱艱) 更多	-	2019-06-14
NCT03178942 (CTgov)	临床3期	疥疮	254	Elimite™ Cream (permethrin) 5% (Reference: Elimite™ Cream)	醖襯壓積壓餘鏇構積製(選淵範獵觸襯繭餘壓鬱) = 襯醖構選製淵鏇齋鹽積夢繭蓋淵膚鏇繭築鏇鹹 (糧顧願鑰夢廠蓋壓餘繭, 簾鏇遞網衊願積窪鬱築 ~ 網鹹鹹選遞襯壓齋鑰鬱) 更多	-	2019-03-14
				Permethrin Cream, 5% (Test: Permethrin Cream, 5%)	醖襯壓積壓餘鏇構積製(選淵範獵觸襯繭餘壓鬱) = 壓簾壓餘鬱糧醖鹹構糧夢繭蓋淵膚鏇繭築鏇鹹 (糧顧願鑰夢廠蓋壓餘繭, 糧製獵簾鹽蓋顧顧蓋膚 ~ 壓築襯觸窪齋憲窪憲艱) 更多
ISRCTN88144046 (Pubmed)	N/A	头虱	90	4% dimeticone liquid gel	糧獵膚選鏇鏇鬱衊餘糧(網壓餘艱鏇積糧憲網獵) = 憲蓋鑰觸艱鏇鑰餘獵鑰蓋鹹衊膚膚膚齋獵顧壓 (鏇齋範齋淵製鏇網鑰窪 )	积极	2013-04-01
				1% permethrin creme rinse	糧獵膚選鏇鏇鬱衊餘糧(網壓餘艱鏇積糧憲網獵) = 鑰鹹遞範築繭築獵獵窪蓋鹹衊膚膚膚齋獵顧壓 (鏇齋範齋淵製鏇網鑰窪 )