Omega-3-acid ethyl esters(Trygg Pharma AS)

ORLANDO, Fla., March 7, 2025 /PRNewswire/ -- The 2025 American Academy of Dermatology Annual Meeting will take place March 7-11 in Orlando. The meeting will feature nearly 300 educational sessions with more than 1,700 speakers discussing the latest research on skin, hair, and nails, including topics on how diet and lifestyle can transform skin health, eczema management, and insights into aging skin. A New Era in Skin Health: GLP-1 Medications Your skin is often a window to your overall health, including underlying inflammatory and metabolic conditions. New treatments, like GLP-1 medications commonly used for weight loss, can help manage obesity, reduce inflammation, and improve skin conditions, highlighting how board-certified dermatologists are advancing personalized care. Inflammation and Skin Conditions Are Linked: Obesity often causes inflammation that can worsen or trigger skin conditions like psoriasis, eczema, and hidradenitis suppurativa, a chronic disease that causes painful lumps to form under the skin. GLP-1 Medications and Your Skin: While originally developed to treat diabetes and, more recently, promote weight loss, GLP-1 medications can reduce inflammation caused by obesity and improve certain skin conditions. A New Era of Dermatology: Treating conditions like obesity can bring about a healthier 'you' and help skin treatments work better, leading to more complete care. Lindsey Bordone, MD, FAAD, an assistant professor of dermatology at Columbia University Department of Dermatology, can discuss the connection between obesity and skin health, and how addressing your overall health can benefit your skin and well-being. The Role of Diet in Managing Eczema Many people believe that food is the root cause of atopic dermatitis, commonly known as eczema, which can result in dry, itchy skin. However, the relationship between diet and this common skin condition is more complex than it seems. New research is shedding light on how diet influences eczema – which affects nearly one in ten Americans – and empowers patients to make more informed choices. Cutting Foods Isn't a Cure-All: For most patients, simply eliminating certain foods doesn't significantly improve eczema symptoms, despite common misconceptions. The Role of a Healthy Diet: Emphasizing overall healthy eating and avoiding allergens can still play an important role in managing eczema. Early Allergen Introduction: Introducing allergenic foods early in life may help build tolerance, offering a powerful shift in how people manage their eczema. Peter A. Lio, MD, FAAD, a clinical assistant professor of dermatology at Northwestern Medicine in Chicago, can provide evidence-based strategies for managing eczema through diet and lifestyle. How Diet Can Enhance the Effectiveness of Skin Treatments The foods you eat play a vital role in how well medications work for skin conditions and can even help to minimize possible side effects. By making thoughtful dietary choices, you can support your skin health, maximize the effectiveness of treatments for skin disease, and improve your overall health. Optimize Treatment with Nutrition: The Mediterranean diet, which encourages people to eat plant-based foods, and omega-3 fats, can help make biologic treatments for psoriasis more effective, while also reducing heart disease risks associated with this common skin condition. Support Immunotherapy with Fiber: For advanced melanoma, the deadliest form of skin cancer, a diet rich in fiber from fruits, vegetables, and whole grains enhances the effectiveness of immunotherapy, a cancer treatment that uses the patient's own immune system to fight the disease. At the same time, patients should avoid probiotic supplements, which can make treatments less effective. Complement Therapy with Supplements: For those who suffer from acne, omega-3 supplements improve the absorption of isotretinoin, a common acne medication, and minimize its side effects. Steven Daveluy, MD, FAAD, an associate professor of dermatology at Wayne State University in Dearborn, Michigan, details how your diet can work alongside your treatment plan for healthier skin and a healthier you. Understanding Itch: A Window into Aging Skin Itch is the most common symptom for which patients over 50 visit a dermatologist. Importantly, recent scientific breakthroughs and treatment innovations are revolutionizing dermatologists' understanding and management of this condition. More than a symptom, itch offers valuable insights into how the immune system, nervous system, and skin barrier – the outermost layer of skin that serves as a protective shield for the body – change as we age. Increasingly More Common and Severe: Itch becomes more common and severe with age, significantly impacting quality of life, including sleep, daily activities, and our ability to care for others. Complicated Causes in Older Adults: Diagnosing the cause of itch in older adults is harder because visual signs and lab clues are less definitive. This can result in undertreatment. Evolving Treatments: While there are no FDA-approved medications specifically for itch, dermatologists have a variety of treatments at hand to address its effects, including moisturizers as well as topical ointments, phototherapy, biologics – which target diseases throughout your body and neurologic treatments like nerve creams and oral medications. Daniel C. Butler, MD, FAAD, an assistant dean and an associate professor of dermatology at University of Arizona College of Medicine in Tucson, can discuss the types of personalized treatment options dermatologists recommend for patients who struggle with persistent itch. If you have questions about a skin, hair, or nail condition, consult a board-certified dermatologist to ensure you receive trusted, expert guidance tailored to your needs. About the AAD Headquartered in Rosemont, Ill., the American Academy of Dermatology, founded in 1938, is the largest, most influential and most representative of all dermatologic associations. With a membership of more than 21,000 physicians worldwide, the AAD is committed to advancing the diagnosis and medical, surgical, and cosmetic treatment of the skin, hair, and nails; advocating high standards in clinical practice, education and research in dermatology; and supporting and enhancing patient care because skin, hair, and nail conditions can have a serious impact on your health and well-being. For more information, contact the AAD at (888) 462-DERM (3376) or aad.org. Follow @AADskin on Facebook, Pinterest, and YouTube, and @AADskin1 on Instagram. SOURCE American Academy of Dermatology WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

▎药明康德内容团队编辑  延缓衰老是许多人梦寐以求的目标，目前科学家已经提出了一些潜在的抗衰手段，一种是通过靶向衰老细胞的抗衰疗法，例如senolytic疗法。该类策略主要通过各类小分子来清除功能异常、引发慢性炎症的衰老细胞，以此减少年龄相关疾病的发生风险。但这类策略的安全性、有效性仍需要广泛的临床试验来进行验证。 相对来说，更加适合普通人的抗衰方式还是饮食与运动。但摄入哪些营养素，如何进行组合能获得更好的抗衰效果，仍需要更多研究进行探索。根据近期《自然-衰老》杂志发表的一项研究，omega-3具备良好的延缓衰老效果。不论志愿者的性别、体重和年龄，只要补充了omega-3，就能有效地延缓表观遗传衰老速度。如果在补充omega-3的同时，搭配维生素D和日常运动，还能进一步提升抗衰效果。 omega-3是一种常见于深海鱼油的不饱和脂肪酸，经常补充可以有效帮助维护心血管健康。过往研究发现omega-3能够降低心力衰竭、冠心病、脑梗等疾病的风险，并且具备减缓动物衰老的潜在作用。 图片来源：123RF 为了深入探索补充剂和运动对健康的影响，瑞士苏黎世大学的研究者参与开展了一项临床试验DO-HEALTH。该试验招募了2000多名70岁以上的老年群体，用于分析omega-3、维生素D以及居家运动在预防老年疾病以及延长健康寿命的作用。 在所有志愿者中，有700多名参与了上述条件对抗衰作用的试验。研究者评估衰老的标准为表观遗传时钟，这是一种根据DNA甲基化水平来判断生物学年龄与实际年龄差异的方法。在第1代版本基础上，目前已经更新迭代发展出3代表观遗传时钟，包括基于死亡风险研发的第2代时钟（PhenoAge、GrimAge、GrimAge2）和基于器官系统完整性分析研发的第3代时钟DunedinPACE。 参与试验的志愿者会被分成8个组，除了安慰剂对照组，他们分别按照单独补充omega-3（每日1g）、维生素D（每日2000 IU）和日常运动（每周3次，每次30分钟），以及组合接受其中两种或三种的方式进行分组。 ▲试验分组示意图（图片来源：参考资料[1]） 研究人员发现，单独每日补充omega-3可以有效地延缓志愿者的生物学衰老，他们在4个表观遗传时钟的3个中观察到了延缓衰老趋势。单独补充维生素D、日常运动没有明显的延缓衰老效果。根据PhenoAge和GrimAge时钟显示的结果，在3年的追踪期持续补充omega-3，可以有效将生物学年龄减少2.9-3.8个月。PhenoAge时钟结果还表明，如果在补充omega-3的基础上，额外引入其他两类干预方式能进一步增强抗衰效果。 根据GrimAge时钟，作者发现从DNA甲基化修饰层面来看，一些血浆蛋白指标物会对omega-3补充剂产生变化，比如纤溶酶原激活剂抑制物-1，瘦素抑制分子TIMP-1。在组合干预条件下，生长分化因子15以及β2微球蛋白也会受到影响。 ▲不同干预措施对表观遗传时钟的影响（图片来源：参考资料[1]） 除了抗衰，过往的DO-HEALTH试验结果显示，单独补充omega-3可以使感染、摔倒的发生率分别降低13%和10%。三种干预措施组合使用，能够使脆弱前（prefrailty，一种介于健康与脆弱的中间态）风险降低39%，侵袭性癌症风险发生下降61%。 尽管omega-3有着各种效果，但它并非越多越好，研究中的补充剂量为每日1克。针对其他疾病的研究显示，omega-3在每日补充2~3克的范围时可以在降压中发挥最佳的效果，受试者的收缩压和舒张压平均降低了2 mm Hg左右，而超过每日3克并不会带来显著的额外益处。 另一方面，每日补充2~3克omega-3，可以帮助降低甘油三酯、高密度脂蛋白胆固醇等脂质的水平。而在选择鱼油的时候，需要选择omega-3纯度较高的产品，实现有效补充omega-3的效果。 推荐阅读 《柳叶刀》子刊：肥胖加速衰老，与52种疾病风险升高有关！ 抗衰降心血管风险！重磅综述：3大进展，应对衰老挑战 增加心血管、痴呆等风险！预防衰老“秘诀”，可见于这两大策略 大脑是如何“老化”的？《柳叶刀》子刊：运动能力下降比认知衰退早10年！ 参考资料： [1] Bischoff-Ferrari, H.A., Gängler, S., Wieczorek, M. et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nat Aging (2025). https://doi.org/10.1038/s43587-024-00793-y 本文来自药明康德内容微信团队，欢迎转发到朋友圈，谢绝转载到其他平台。如有开设白名单需求，请在“学术经纬”公众号主页回复“转载”获取转载须知。其他合作需求，请联系wuxi_media@wuxiapptec.com。 免责声明：药明康德内容团队专注介绍全球生物医药健康研究进展。本文仅作信息交流之目的，文中观点不代表药明康德立场，亦不代表药明康德支持或反对文中观点。本文也不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。 分享，点赞，在看，传递医学新知