更新于：2024-11-04
Flupenthixol Hydrochloride/Melitracen Hydrochloride
氟哌噻吨美利曲辛
更新于：2024-11-04
概要
基本信息
药物类型 小分子化药 |
别名 Flupentixol and Melitracen、盐酸氟哌噻吨/盐酸美利曲辛、Deanxit + [1] |
作用机制 DRDs拮抗剂(多巴胺受体家族拮抗剂)、单胺再摄取抑制剂 |
治疗领域 |
非在研适应症 |
原研机构 |
在研机构- |
最高研发阶段批准上市 |
首次获批日期- |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C52H67F3N4O2S |
InChIKeyMKWJDUAOJQMMSS-UHFFFAOYSA-N |
CAS号214556-54-4 |
关联
19
项与 氟哌噻吨美利曲辛 相关的临床试验氟哌噻吨美利曲辛片在健康受试者中的单剂量、空腹/餐后、随机、开放、两制剂、两周期、两交叉生物等效性研究
氟哌噻吨美利曲辛片在中国健康受试者中单中心、随机、开放、单次给药、两制剂、两周期交叉人体生物等效性研究
Efficacy of Deanxit with Tandospirone Citrate in Functional Dyspepsia Patient with anxiety and depression: A Randomized Controlled Trial
100 项与 氟哌噻吨美利曲辛 相关的临床结果
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100 项与 氟哌噻吨美利曲辛 相关的转化医学
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100 项与 氟哌噻吨美利曲辛 相关的专利（医药）
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35
项与 氟哌噻吨美利曲辛 相关的文献（医药）2024-11-01Genes & Diseases
The efficacy and safety of NeuroWell antidepressant dietary supplement, Deanxit, and their combination in the treatment of mild-to-moderate depression: A randomized clinical trial
Article
作者: Wang, Wenwen ; Guo, Shang ; Wen, Xuejun ; Zhou, Qiqi ; Liu, Yue ; Ning, Yaochao ; Li, Zhen ; Zhang, Hui ; Wang, Qinglu ; Liu, Dechen ; Geng, Shuang ; Wang, Yutong ; Sui, Zhuxin ; Wang, Shanshan ; Sun, Lei ; Liu, Ping ; Yin, Honglei ; Wang, Hongwei ; Wang, Yunliang ; Wei, Dianfang ; Deng, Youping ; Liu, Yanqiu ; Liu, Yajun ; Zhang, Huaibo ; Wang, Yanchao ; Li, Jinfeng ; Zhang, Kezhong ; Yin, Hongtao
Then,a total of 242 participants were recruited,and 200 were eventually enrolled and randomly grouped (n Z 50)for the study.None of the patients in any of the four groups had dropped out by 12 wk.
2024-10-01Molecular neurobiology
Paroxetine Effect on Nerve Growth Factor, Human Neurotrophin-4, Brain-Derived Neurotrophic Factor Levels in Post-stroke Depression
Article
作者: Yu, Lamei ; Jin, Yuhua ; Li, Yan
The aim of this study is to explore paroxetine's effect on nerve growth factor (NGF), human neurotrophin-4 (NT-4), and brain-derived neurotrophic factor (BDNF) levels in post-stroke depression. Ninety-two post-stroke depression patients from April 2021 to April 2023 in our hospital were selected and numbered 1 to 92 after enrollment. Forty-six patients with odd number and 46 patients with even number were, respectively, included in the control and observation group. In addition to basic treatment, control group was treated with flupentixol melitracen tablets orally, and observation group received paroxetine hydrochloride orally. The levels of NGF, NT-4, BDNF, 5-hydroxytryptamine (5-HT), homocysteine (Hcy), noradrenaline (NE), Hamilton Depression Scale (HAMD) changes of National Institute of Health Stroke Scale (NIHSS). NGF, NT-4, and BDNF levels were compared between groups at T0, T1, and T2 levels were higher, and the levels at T2 were higher than those at T1, and observation group levels were higher (P < 0.05); NGF, NT-4, and BDNF levels were compared among groups, time, and interaction. 5-HT, Hcy, and NE levels at T0 were compared between groups; 5-HT and NE levels at T1 and T2 were higher than those at T0, the levels at T2 were higher than those at T1, and observation group levels were higher (P < 0.05); Hcy level at T1 and T2 was lower, its level at T2 was lower than those at T1, and observation group levels were lower (P < 0.05); 5-HT, Hcy, and NE levels were compared among groups, time, and interaction (P < 0.05). HAMD and NIHSS at T0 were compared; T1 and T2 were lower than T0, T2 was lower than T1, and observation group was lower (P < 0.05); HAMD and NIHSS were compared among groups, time, and interaction (P < 0.05). For post-stroke depression, paroxetine treatment can effectively improve NGF, NT-4, BDNF, 5-HT, Hcy, and NE levels and effectively reduce the degree of neurological damage and depression, which has high clinical application value.
2024-03-01Heliyon
Beyond the counter: Navigating the landscape of Deanxit® dispensing – Insights from Jordanian community pharmacies
Article
作者: Barakat, Muna ; Ahmad, Rawand E
Background:
This study investigates the dispensing patterns and knowledge of community pharmacists regarding Deanxit®, a combination of melitracen and flupentixol approved for the treatment of depression and anxiety in Jordan.
Methods:
This study employed a mixed-methods approach, involving 75 randomly selected pharmacies in two Jordanian governorates (Amman and Irbid). The investigation involved simulated patient scenarios and structured interviews employing a validated tool.
Results:
The analysis revealed that 70.6% of pharmacists were willing to dispense Deanxit® based on simulated scenarios, indicating malpractice. The mean practice score was 0.5867 out of 18, underlining a substantial level of malpractice. Pharmacists demonstrated poor knowledge, with a median score of 2.0 out of 15, reflecting a lack of awareness about Deanxit's labeled indications. Furthermore, 96% reported dispensing without prescriptions, and 62.1% acknowledged encountering cases of improper Deanxit® use.
Conclusion:
This study provides valuable insights into the current landscape of Deanxit® dispensing patterns, pharmacists' poor knowledge levels, and malpractices in Jordan. By identifying areas for improvement and offering recommendations for intervention, this study contributes to enhancing pharmacy practice and patient care outcomes in the region.
100 项与 氟哌噻吨美利曲辛 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 焦虑症 | 中国 | - | - |
| 抑郁症 | 中国 | - | - |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 阿片相关性障碍 | 临床3期 | 中国 | 2014-10-14 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 160 | Control group | 築襯憲鑰簾築鑰艱顧淵(遞廠膚衊鬱鹹齋膚構鏇) = 壓衊簾鏇繭鏇醖顧鬱窪 範齋製壓餘壓憲壓齋餘 (繭範鹹壓窪憲襯遞獵顧 ) | - | 2019-06-15 | ||
築襯憲鑰簾築鑰艱顧淵(遞廠膚衊鬱鹹齋膚構鏇) = 壓鏇繭糧顧觸蓋網鏇淵 範齋製壓餘壓憲壓齋餘 (繭範鹹壓窪憲襯遞獵顧 ) | |||||||
临床4期 | 262 | 鑰築鹹糧鹽願顧鹹網蓋(蓋製壓遞醖觸齋衊選廠) = 夢衊衊鬱築願窪選艱窪 鹽顧蓋齋醖窪製襯築淵 (淵憲鹹獵淵衊衊築網鬱, 鬱衊衊膚鏇築築遞顧製 ~ 構製壓網鹽繭選鑰醖範) 更多 | - | 2015-02-23 |
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