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更新于：2025-05-16
Cyproheptadine Hydrochloride
盐酸赛庚啶
更新于：2025-05-16
概要
基本信息
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C42H50Cl2N2O3 |
InChIKeyZEAUHIZSRUAMQG-UHFFFAOYSA-N |
CAS号41354-29-4 |
关联
31
项与 盐酸赛庚啶 相关的临床试验NCT06751290
The Use of Cyproheptadine to Improve Eating Habits in Children With Pediatric Feeding Disorders
IRCT20240213060992N1
Comparing the effect of low dose and standard dose Cyproheptadine on BMI enhancement in children aged 2-10 and evaluation of its side effects
NCT06147622
A Phase 1, Open-label, Cross-over Study in Healthy Volunteers to Assess the Pharmacokinetic Profile of Prazosin and Cyproheptadine Following Single Dose Oral Administration of KT110 Tablet and Following Administration of Alpress and Periactin Marketed Tablets
100 项与 盐酸赛庚啶 相关的临床结果
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100 项与 盐酸赛庚啶 相关的转化医学
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100 项与 盐酸赛庚啶 相关的专利（医药）
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3,744
项与 盐酸赛庚啶 相关的文献（医药）2025-12-01MOLECULAR BIOLOGY REPORTS
Repurposing serotonergic drugs for gastric cancer: induction of apoptosis in vitro
Article
作者: Ahangari, Ghasem ; Amjadi, Omolbanin ; Abedini, Fatemeh
BACKGROUND:
Gastric cancer is a highly heterogeneous and aggressive disease with limited treatment options, necessitating innovative therapeutic strategies. Drug repurposing, a cost-effective approach, offers opportunities to identify new applications for existing medications. This study systematically investigated the apoptotic effects of serotonergic drugs on MKN-45 gastric cancer cells, providing a novel perspective on serotonin signaling in cancer therapy.
METHODS AND RESULTS:
MKN-45 cells were treated with concentrations of Tropisetron, Imipramine, Ketanserin, Citalopram, and Cyproheptadine. The IC50 values were determined using an MTT assay, while acridine orange/ethidium bromide staining and Annexin V/PI flow cytometry assessed apoptotic activity. Gene expression related to serotonin receptors (HTR2A, HTR2B, HTR3A), Serotonin transporter (SLC6A4), apoptosis (Bcl-2, Bax), and proliferation (PCNA) was evaluated via real-time PCR. Tropisetron, Imipramine, Ketanserin, and Cyproheptadine demonstrated statistically significant apoptotic induction compared to untreated cells. These treatments significantly reduced anti-apoptotic Bcl-2 and PCNA, proliferation marker, expression, while pro-apoptotic Bax expression was markedly elevated (p < 0.05).
CONCLUSIONS:
This study highlights the potential of Tropisetron, Imipramine, Ketanserin, and Cyproheptadine as repurposed drugs for gastric cancer therapy, with Tropisetron and Imipramine showing particularly promising apoptotic effects. These findings pave the way for further preclinical and clinical investigations, offering a foundation for personalized therapeutic strategies in gastric cancer management.
2025-06-01BIOMEDICINE & PHARMACOTHERAPY
Enhanced tumor suppressive effect of a new HDAC inhibitor in bladder cancer in vitro and in vivo
Article
作者: Liu, Hsin-Ting ; Lee, Ming-Yang ; Wang, Shou-Chieh ; Wu, Jin-Yi ; Liu, Yi-Wen ; Wu, Pei-Xuan ; Huang, Say-Wei ; Chan, Kun-Wei ; Shen, Cheng-Huang
Bladder cancer has a high recurrence rate, which indicates that the therapeutic effects of advanced bladder cancers are still limited. In this study, we combined vorinostat and cyproheptadine as a new treatment for bladder cancer. When combining the two drugs, an additive to synergistic effect is discovered. Furthermore, we modified the structure of vorinostat using cyproheptadine tricyclic ring to get compounds 8 C and O8C, which keep HDAC inhibitory activity and have IC50 lower than 10 μM in 5637, BFTC 905, and MB49 cells. In in vitro assay, vorinostat, 8 C and O8C increased the percentage of cell cycle in G2/M in 5637, while G0/G1 arrest in BFTC 905. Apoptosis was seen in 5637 and slightly in BFTC 905 by the Annexin V-PI staining assay, and a minor rescued cell viability after Z-VAD-FMK pretreatment in 5637. 8 C and O8C slightly decreased MMP, and increased ROS levels. Among different ROS scavenger treatments, only N-acetyl-L-cysteine shows a minor viability rescue, indicating ROS may not take an important role in 8C- and O8C-induced cell death. In the in vivo assay, mice underwent intraperitoneal injection of 8 C, delaying tumor growth compared to cyproheptadine, vorinostat, and O8C individually. Because the water solubility of 8 C is not good, we use its salt form 8C-HCl for further in vivo study. Mice underwent gavage of 8C-HCl, which resulted in delaying tumor growth. In conclusion, 8 C and 8C-HCl, from structure modification of vorinostat by cyproheptadine tricyclic ring, enhance tumor suppressive effect in vitro and in vivo.
2025-06-01FOOD CHEMISTRY
High-throughput screening of new psychoactive substances and related compounds in food by UHPLC-Q/Orbitrap
Article
作者: Huang, Xia ; Wan, Yuping ; Shi, Peiyu ; Wu, Wenlin ; Xiao, Quanwei ; Liu, Shiyao ; Guo, Tianrong ; Chen, Xiaoqi ; Zhou, Yan ; Xia, Bing ; Zhang, Min
Currently, there is concern about food products to which new psychoactive substances (NPS) have been added illegally. However, rapid, high-sensitivity, and high-throughput screening methods for such harmful substances have not been reported yet. In this study, a high-throughput non-targeted screening strategy was developed based on UHPLC-Q/Orbitrap. First, optimized pretreatment methods for typical high-risk matrices were established. Second, an accurate, efficient, and scalable high resolution mass spectrometry database containing 206 NPS and related compounds was constructed. The fragmentation pathways of three different types of fentanyl-related compounds were then systematically investigated to enhance compound identification. Additionally, a non-targeted screening strategy was developed using warning ions derived from 24 fentanyl-related compounds, streamlining the identification of NPS. This strategy was applied to 100 food samples with possible illegal additives and demonstrated its effectiveness. In summary, this study provides robust technical support for regulatory authorities in combating the illegal addition of food products.
100 项与 盐酸赛庚啶 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 湿疹 | 中国 | 1982-01-01 | |
| 食欲减退 | 日本 | 1971-01-01 | |
| 结膜炎 | 美国 | 1961-10-17 | |
| 常年性变应性鼻炎 | 美国 | 1961-10-17 | |
| 瘙痒 | 日本 | 1961-08-11 | |
| 过敏性鼻炎 | 日本 | 1961-08-11 | |
| 荨麻疹 | 日本 | 1961-08-11 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 4 | (No Cyproheptadine Treatment) | 簾觸選築築鏇膚醖網遞(鹹廠積顧蓋繭範蓋觸鹹) = 獵淵鬱壓憲糧觸齋鹹糧 襯鹽憲餘襯遞夢選膚鹹 (夢選憲鏇觸鹽衊淵獵廠, 選壓夢築願觸鹽襯夢願 ~ 鏇築膚遞醖鬱鏇選衊糧) 更多 | - | 2020-01-31 | ||
(Continuous Cyproheptadine) | 簾觸選築築鏇膚醖網遞(鹹廠積顧蓋繭範蓋觸鹹) = 膚遞醖鹽選憲鹽鑰壓鹽 襯鹽憲餘襯遞夢選膚鹹 (夢選憲鏇觸鹽衊淵獵廠, 積顧餘願齋鬱餘鹽鏇鹹 ~ 築製艱襯網衊糧襯糧艱) 更多 | ||||||
临床3期 | 22 | (Arm I Cyproheptadine Hydrochloride) | 鏇築積鏇餘淵膚鹽觸鑰 = 獵齋壓鏇網鹽襯顧願艱 鬱遞觸繭壓衊鹽網簾夢 (襯觸顧襯繭鑰製繭築餘, 獵遞築齋鏇艱餘鏇餘選 ~ 淵鹽鬱觸範淵鑰顧衊夢) 更多 | - | 2015-07-02 | ||
placebo (Arm II Placebo) | 鏇築積鏇餘淵膚鹽觸鑰 = 衊願廠艱糧觸醖壓網網 鬱遞觸繭壓衊鹽網簾夢 (襯觸顧襯繭鑰製繭築餘, 夢築糧艱願遞網築構淵 ~ 糧選襯夢鹽繭構餘壓淵) 更多 | ||||||
N/A | - | 構構鏇齋窪醖夢衊積膚(壓簾憲觸築構壓齋鏇積) = 廠遞鹹糧構壓製製齋夢 觸壓鏇憲繭鹽鑰艱選蓋 (衊遞醖顧構襯糧製壓壓, 1.2) | - | 2010-11-17 | |||
Placebo | 構構鏇齋窪醖夢衊積膚(壓簾憲觸築構壓齋鏇積) = 鹹觸範觸網範製糧獵廠 觸壓鏇憲繭鹽鑰艱選蓋 (衊遞醖顧構襯糧製壓壓, 1.2) | ||||||
临床2期 | 70 | Cyproheptadine hydrochloride (CH) | 蓋範鬱選醖糧窪蓋簾齋(鹹選顧願膚選餘糧壓窪) = The most commonly reported side effect of CH was drowsiness 艱繭構繭醖鹽遞網齋餘 (積廠鹽構獵衊選顧構顧 ) 更多 | 积极 | 2008-11-01 | ||
Megestrol acetate (MA) |
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