预约演示
更新于：2026-10-11
Autologous anti-CD19 CAR-T cells expressing a shRNA against IL-6(Shanghai Unicar)
沉默白介素6表达功能的靶向CD19基因工程化自体T细胞(上海优卡迪)
更新于：2026-10-11
概要
基本信息
药物类型 自体CAR-T |
别名 ssCART-19、ssCART-19 cells、ssCART-19(Shanghai Unicar) + [2] |
靶点 |
作用方式 抑制剂 |
作用机制 CD19抑制剂(B淋巴细胞抗原CD19抑制剂) |
在研适应症 |
原研机构 |
非在研机构- |
权益机构- |
最高研发阶段临床2期 |
首次获批日期- |
最高研发阶段(中国)临床2期 |
特殊审评孤儿药 (美国) |
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关联
8
项与 沉默白介素6表达功能的靶向CD19基因工程化自体T细胞(上海优卡迪) 相关的临床试验NCT06987916
A Single-Arm, Open-Label Clinical Study on the Efficacy and Safety of U01 (ssCART-19) in the Treatment of Relapsed or Refractory B-Cell Lymphoma
NCT07093073
A Single-arm, Open-label Clinical Study Evaluating the Efficacy and Safety of U01 (ssCART-19) in Patients With Relapsed or Refractory B-cell Lymphoma.
NCT06367114
Phase Ⅱ Clinical Trial of ssCART-19 Cell Injection in the Treatment of CD19 Positive Relapsed or Refractory Acute Lymphoblastic Leukemia (Including Central Nervous System Infiltration)
100 项与 沉默白介素6表达功能的靶向CD19基因工程化自体T细胞(上海优卡迪) 相关的临床结果
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100 项与 沉默白介素6表达功能的靶向CD19基因工程化自体T细胞(上海优卡迪) 相关的转化医学
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100 项与 沉默白介素6表达功能的靶向CD19基因工程化自体T细胞(上海优卡迪) 相关的专利（医药）
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50
项与 沉默白介素6表达功能的靶向CD19基因工程化自体T细胞(上海优卡迪) 相关的文献（医药）2026-10-01ENVIRONMENTAL POLLUTION
Divergent impacts of microplastics and related leachates on sediment carbon and nitrogen transformation by regulating microbial communities and functions
Article
作者: Huang, Jinhui ; He, Wenjuan ; Hu, Jinying ; Qiao, Qi ; Zhao, Lizi ; Li, Yuanyuan ; Wang, Simiao ; Liu, Zhexi ; Ma, Mengyu ; Shi, Lin
Microplastics (MPs) are recognized as potential disruptors of biogeochemical cycles. However, the differential impacts of MPs types and related leachates remain poorly understood, particularly for nitrogen-containing MPs. This study compared the variational responses in sediment carbon and nitrogen transformation to 1% aged MPs (AMPs), leachates (LMPs), washed aged MPs particles (WMPs) derived from nitrogen-containing polyamide (PA) and non-nitrogen-containing polylactic acid (PLA) under natural exposure and freeze-thaw cycles (FTCs). The results showed that the Carbon Pool Management Index (CPMI) in PLA groups was always higher than corresponding PA groups, indicating better sediment quality in the PLA groups. Under natural exposure, LPA and LPLA respectively increased CPMI by 3.4% and 93.6% due to containing biologically available organic matter. FTCs increased CPMI by 34.1% in control groups, whereas only CMPI in AMPs was higher than control groups. Besides, the PLA group reduced the nitrogen mineralization rate by possibly inhibiting the macromolecular organic matter decomposition, and might have reduced the narG/H/I and nirB/D genes, thereby indirectly maintaining the nitrification rate. While the PA group increased the nitrogen mineralization rate by possibly inhibiting the amoA/B/C genes to reduce nitrification rate and enriching ureolytic microorganisms. FTCs mitigated these disparities by intensifying microbial interactions. PLS-SEM suggested that APLA was most strongly associated with carbon and nitrogen transformation within the PLA treatments, whereas the apparent effect of APA was jointly shaped by the opposite associations of WPA and LPA. These findings provide new insights into the complex ecological effects of MPs and their leachates on sediment carbon and nitrogen transformations.
2026-07-01GLOBAL CHANGE BIOLOGY
Responses of Soil Carbon Release to Freeze–Thaw Cycles Mediated by Carbon Availability at Regional and Global Scales
Article
作者: Chen, Leiyi ; Qin, Shuqi ; Wang, Siyu ; Kang, Luyao ; Yang, Yuanhe ; Yang, Yan
ABSTRACT:
Soil freeze–thaw cycles (FTCs) are widespread across mid‐ to high‐latitude and high‐altitude regions, with particularly high frequency in permafrost areas where they can enhance soil carbon release and potentially accelerate climate warming. However, the response of soil carbon release to FTCs and its determinants at the regional scale remain unclear due to the lack of direct experimental evidence. Here, based on topsoil samples along a 1000‐km transect across the Tibetan permafrost region, we conducted a freeze–thaw microcosm experiment (5 cycles of 1‐day freezing and 3‐day thawing) to investigate patterns and predictors of FTC‐induced soil carbon dioxide (CO
2
) release. The results revealed that FTCs significantly increased soil CO
2
release by 20% ± 2% relative to the thaw‐only control across all cycles. This response was primarily driven by soil carbon availability rather than microbial properties. Soils with higher carbon availability, as indicated by initially (prior to FTCs) larger soil organic carbon content and less mineral‐protected carbon, as well as greater post‐thaw increases in dissolved organic carbon, released more CO
2
under FTCs. Such an effect of carbon availability was further confirmed at the global scale. Although FTCs altered the microbial community composition, notably leading to an increase in the proportion of
r
‐strategists, microbial properties played a minor role in influencing the CO
2
release. These results demonstrate the crucial role of soil carbon availability in affecting responses of CO
2
release to FTCs, highlighting the need for models to explicitly characterize pulsed CO
2
release associated with substrate availability to better predict permafrost carbon‐climate feedback.
2026-06-01JOURNAL OF HAZARDOUS MATERIALS
Freeze-thaw aging and microbial colonization converts microplastics into nitrogen cycling hotspots
Article
作者: Mei, Xintong ; He, Yixin ; Li, Naying ; Liu, Xin ; Zhong, Bo ; Yi, Shaoliang ; Liu, Ruixi ; Wu, Wei-Min ; Zhou, Li ; Ambrosini, Roberto
As global warming intensifies, the frequency of freeze-thaw events increases, significantly impacting microbial metabolism and biogeochemical cycling. However, the synergistic effects of freeze-thaw cycles (FTCs) and pervasive microplastics (MPs) on microbial community assembly and nitrogen cycling remain poorly understood. Here, we conducted a microcosm experiment integrating metagenomic and random forest model to elucidate the co-regulatory mechanisms of FTCs and MPs on plastisphere microbial communities and nitrogen metabolism. Results revealed that FTCs accelerated the environmental aging of MPs, inducing surface cracking and oxidation, thereby creating microenvironments favorable for microbial colonization. In the experimental microcosms, the combined effects of FTCs and presence of MPs increased microbial richness and diversity, promoted community differentiation between sediment and plastisphere, and increased microbial niche specialization. Functional analyses showed that FTCs induced a functional reconfiguration of the plastisphere nitrogen metabolism, with a selective enrichment of key enzyme genes, such as nitrite reductase, which may enhance nitrite redox activity and N₂O emission capacity. In the plastisphere, the contribution of Acinetobacter to nitrogen cycling increased, whereas Nitrospira declined, possibly due to oxygen limitation. Overall, our findings suggested that FTCs may facilitate transformation of MPs from inert pollutants into potentially metabolically active microhabitats, providing critical insights for assessing emerging pollutants and climate change.
35
项与 沉默白介素6表达功能的靶向CD19基因工程化自体T细胞(上海优卡迪) 相关的新闻（医药）2026-08-06
100 项与 沉默白介素6表达功能的靶向CD19基因工程化自体T细胞(上海优卡迪) 相关的药物交易
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研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| CD19阳性B细胞急性淋巴细胞白血病 | 临床2期 | 中国 | 2024-05-14 | |
| CD19阳性急性淋巴细胞白血病 | 临床2期 | 中国 | 2024-04-01 | |
| CD19阳性急性淋巴细胞白血病 | 临床2期 | 中国 | 2024-04-01 | |
| 伴有骨髓发育不良相关变化的急性髓系白血病 | 临床2期 | 中国 | 2017-10-18 | |
| 成人急性淋巴细胞白血病 | 临床2期 | 中国 | 2017-07-10 | |
| 难治性B细胞淋巴瘤 | 临床1期 | 中国 | 2025-01-23 | |
| 难治性成人急性淋巴细胞白血病 | 临床1期 | 中国 | 2021-04-09 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1期 | 14 | 鹹鏇觸窪壓願顧餘鏇襯(衊簾繭鏇襯齋齋糧構蓋) = 窪顧鑰糧選範鹹鹽鏇願 鏇鏇網鏇襯齋淵廠壓膚 (膚獵鬱鬱壓齋網憲願範 ) 更多 | 积极 | 2025-12-06 | |||
(PCNSL) | 廠艱衊選憲鏇膚鬱襯襯(蓋鏇衊淵膚鏇觸壓憲壓) = 構鏇衊艱衊簾醖鹽艱觸 醖窪網網窪積積鹽膚製 (繭廠壓艱鹽鬱範鑰製鏇 ) 更多 | ||||||
临床1期 | 17 | 醖網獵壓遞蓋鹽壓鏇顧(壓製選觸遞範壓顧憲選) = No DLT was observed among participants. 窪簾艱繭製鬱艱淵淵淵 (壓範膚構膚鏇齋範選糧 ) 更多 | 积极 | 2025-10-27 | |||
(low-dose cohorts) | |||||||
临床1期 | 17 | 觸艱願簾範淵構觸鏇壓(襯鏇蓋蓋構積網簾壓遞) = lymphopenia (94.2%), transient neutropenia (88.2%), leukopenia (88.2%), anaemia (70.6%) and thrombocytopenia (58.8%). 襯鹹網齋淵窪網衊鹽觸 (襯襯鬱憲夢繭願鬱齋鏇 ) 更多 | 积极 | 2024-09-13 | |||
临床1期 | 13 | 糧艱糧遞糧淵觸顧觸膚(糧廠艱餘鏇構願夢積築) = 9 patients (75.0%) developed CRS, and 3 patients (25.0%) were grade 3 CRS 製願構築鹽遞構願窪網 (顧遞獵憲壓齋廠顧繭製 ) 更多 | - | 2023-12-10 |
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