Poly-gamma-glutamic acid-containing vaccine(BL)(Poly-gamma-glutamic acid-containing vaccine(BL))

概要

基本信息

药物类型

治疗性疫苗

别名

Poly-gamma-glutamic acid、poly-γ-glutamic acid

靶点-

作用机制

免疫刺激剂、Natural killer cells刺激剂(自然杀伤细胞刺激剂)

治疗领域

肿瘤消化系统疾病

在研适应症

结直肠癌

非在研适应症

子宫颈发育不良

原研机构

MOA Life Plus Co., Ltd.

在研机构

MOA Life Plus Co., Ltd.

非在研机构

HK inno.N Corp.天津国际生物医药联合研究院

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)无进展

特殊审评-

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关联

3

项与 Poly-gamma-glutamic acid-containing vaccine(BL) 相关的临床试验

KCT0005083 / CompletedN/A

Effects of polygamma glutamic acid and vitamin B6 supplementation on intestinal bacteria distribution

开始日期2018-10-10

申办/合作机构

National Research Foundation

NCT01826045 / Completed临床2期

A Multi-center, Randomized, Double Blind, Placebo Control, Parallel Design, Phase 2a Trial to Evaluate the Efficacy and Safety of PGA (Poly-gamma Glutamic Acid) for the Fertile Women With Cervical Intraepithelial Neoplasia 1 (CIN1)

The purpose of this study is to determine the efficacy and the safety of PGA(Poly-gamma Glutamic Acid) for the the fertile women with Cervical Intraepithelial Neoplasia (CIN1).

开始日期2013-06-01

申办/合作机构

MOA Life Plus Co., Ltd.

KCT0000339 / RecruitingN/AIIT

A week, double-blind, randomized, placebo-controlled clinical trial for the evaluation of the efficacy and safety of poly-gamma-glutamic acid(0.15g/day) on reducing serum triglycerides of male and female adults(200mg/dl<= serum triglycerides <500mg/dl)

开始日期2012-02-06

申办/合作机构-

100 项与 Poly-gamma-glutamic acid-containing vaccine(BL) 相关的临床结果

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100 项与 Poly-gamma-glutamic acid-containing vaccine(BL) 相关的转化医学

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100 项与 Poly-gamma-glutamic acid-containing vaccine(BL) 相关的专利（医药）

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212

项与 Poly-gamma-glutamic acid-containing vaccine(BL) 相关的文献（医药）

2024-10-01·Science of The Total Environment

Influence of γ-PGA on greenhouse gas emissions and grain yield from paddy rice under different rice varieties

Article

作者: Sheng, Feng ; Zheng, Fei-Xiong ; Yi, Xu-Xu ; Du, Xue-Zhu ; Yang, Cui-Hua ; Li, Shi-Hao

BACKGROUNDSignificant efforts have been devoted to assess the effects of the poly-gamma-glutamic acid (γ-PGA) on crop growth, yield and quality, soil water retention and fertilizer use efficiency. However, few studies have evaluated the effects of γ-PGA on greenhouse gas (GHG) emissions and grain yield from paddy fields with different rice varieties.METHODSIn the present study, a split-plot field experiment was performed to comprehensively evaluate the effects of γ-PGA concentrations (i.e., no application [P0] and 25.0 kg ha^-1 of γ-PGA fermentation solution [P1]) and rice varieties (i.e., conventional rice [Huanghuazhan, H], red rice [Gangteyou 8024, R] and black rice [Black indica rice, B]) on the grain yield, GHG emissions, global warming potential (GWP), greenhouse gas intensity (GHGI), net ecosystem economic profit (NEEP) and carbon footprint (CF) during 2022 and 2023 rice-growing seasons in central China.RESULTSApplication of γ-PGA significantly affected the GHGs emissions, NEEP and CF. Compared with P0 treatments, P1 treatments significantly increased the NEEP by 1.2-11.2 %, and decreased the GWP by 12.9-35.4 %, the GHGI by 16.5-35.9 % and the CF by 13.8-26.2 % in 2022-2023. Application of γ-PGA showed a tendency to increase the yield. Under γ-PGA application condition, R treatment exhibited the lowest GWP, GHGI and CF, and the highest yield and NEEP compared with B and H treatments.CONCLUSIONOur results suggest that γ-PGA application is an ecological agricultural management to increase rice yield, reduce greenhouse gas emission and increase economic benefit, and its advantage is more significant for red rice than for other rice varieties.

2024-09-01·Heliyon

Ameliorative effect of poly-γ-glutamic acid biopreparation on coastal saline soil

Article

作者: Liu, Pei ; Ali, Jawad ; Chang, Tingting ; Hamoud, Yousef Alhaj ; Zheng, Jinhai ; Shaghaleh, Hiba ; Chen, Lihua ; Huang, He

To investigate the effect of poly-γ-glutamic acid (γ-PGA) biopreparation on ameliorating coastal saline soil, three treatments were established: soil salt washed treatment (CK), soil salt washed with added γ-PGA (PGA), soil salt washed with added γ-PGA biopreparation (PGAB). This study determined the effects of γ-PGA on coastal saline soil by analyzing soil aggregate, soil evaporation, soil vertical water and salt distribution, and soil cation content, soil pH, soil nutrient content and soil microorganism quantity. Results showed that γ-PGA had an ameliorative effect on saline soil, with the PGAB treatment exhibiting the most pronounced ameliorative effect compared to CK. Adding PGAB reduced soil evaporation by 30.45 %, soil salt content by 27.91 %, meanwhile increasing plant height by 33.86 %, plant fresh weight by 98.54 %, soil aggregate diameter by 6.68 times, soil water content by 26.47 % (P < 0.05). Additionally, soil total nitrogen was increased by 50.0 % in PGAB treatment, and available nitrogen and phosphorus contents were increased by 1.68 times and 85.83 % (P < 0.05), respectively. Populations of soil-culturable bacteria and fungi of PGAB treatment increased by 65.96 % and 1.23 times, respectively (P < 0.05). After salt-washing process, adding PGAB improved soil physicochemical properties, which altered the ecological environment of rhizosphere soil and promoted plant growth. The results can provide a practical approach for ameliorating coastal saline soils.

2024-08-30·Journal of the Science of Food and Agriculture

Poly‐γ‐glutamic acid enhanced the yield and photosynthesis of soybeans by adjusting soil aggregates and water distribution

Article

作者: Wang, Ying ; Shi, Wenjuan ; Jing, Bo

AbstractBACKGROUNDPoly‐γ‐glutamic acid (γ‐PGA) is employed extensively in agriculture to enhance soil water retention; however, the underlying mechanism by which γ‐PGA improves soil structure and soybean productivity in arid regions remains poorly understood. A micro‐scale field experiment was conducted in the arid region of northwest China, employing five concentrations of γ‐PGA to investigate its impacts on soybean yield, photosynthesis, and water‐use efficiency, as well as soil aggregates and water distribution. The five levels of γ‐PGA were 0 (CK), 10 (P1), 20 (P2), 40 (P3), and 80 kg ha−1 (P4).RESULTSThe results demonstrated that the application of γ‐PGA significantly improved soybean yield, photosynthesis, and chlorophyll content. It resulted in a decrease in soil aggregate content with a maximum diameter of less than 0.053 mm and an increase in the stability of soil aggregates in the uppermost layer of the soil (0–30 cm). The application of γ‐PGA significantly increased soil water content, particularly in the uppermost layer of the soil, and effectively reduced water consumption and improving water use efficiency in soybeans. Overall, the P3 treatment exhibited the most pronounced improvement of soybean yield, photosynthesis, water‐use efficiency, as well as distribution of soil aggregates and water. The correlation matrix heatmap also revealed a strong correlation between improvement of soybean yield or photosynthesis at various γ‐PGA application levels and the enhancement of soil stability or soil water content.CONCLUSIONThe multivariate regression analysis revealed that an optimal application level of 46 kg ha−1γ‐PGA could enhance effectively both yield and water use efficiency of soybean in the arid region of northwest China. © 2024 Society of Chemical Industry.

100 项与 Poly-gamma-glutamic acid-containing vaccine(BL) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
结直肠癌	临床前	韩国	MOA Life Plus Co., Ltd.	2024-03-22
子宫颈发育不良	药物发现	-	HK inno.N Corp.	-
子宫颈发育不良	药物发现	中国	天津国际生物医药联合研究院	-
子宫颈发育不良	药物发现	韩国	MOA Life Plus Co., Ltd.	-

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01826045 (Pubmed \| J Biol Chem)	临床2期	子宫颈发育不良	195	Poly-gamma-glutamic acid (γ-PGA)	(鏇鑰構膚窪鹽遞製壓壓) = 築艱壓鹹憲膚顧鹹製遞製膚廠壓鬱襯膚簾繭憲 (窪醖襯醖選壓簾鏇憲醖 )	-	2019-01-01
				Placebo	(鏇鑰構膚窪鹽遞製壓壓) = 遞夢壓鹹網夢遞壓鑰窪製膚廠壓鬱襯膚簾繭憲 (窪醖襯醖選壓簾鏇憲醖 )