Aortic dissection has acute onset and high mortality, with immunoinflammatory response driving lesion progression. Current perioperative anti-inflammatory therapies are mostly empirical and poorly targeted, and AI-assisted typing lacks a complete clinical translation pathway. This study integrates multi-dimensional data to construct an AI immunoinflammatory subtyping system, enabling rapid subtyping and establishing a "subtyping-target-treatment" closed loop for emergency needs. Using a prospective multicenter RCT, 300 patients are randomly divided into two groups: the experimental group receives subtyping-based precision therapy, while the control group uses empirical strategies (treatment of physician's choice). It observes 7-day postoperative SOFA score, SIRS and other prognostic indicators to provide evidence-based support for precision treatment.

开始日期2027-12-31

申办/合作机构

南京医科大学

[+7]

ChiCTR2600118350

/ Not yet recruitingN/AIIT

A clinical application study on thymalfasin-regulated hypofractionated radiotherapy combined with adebrelimab in hepatocellular carcinoma after PD-1 therapy resistance

开始日期2026-02-09

申办/合作机构-

ChiCTR2600121055

/ Not yet recruiting临床2期IIT

Thymosin α1 treatment for elderly patients with sepsis after discharge: A randomized controlled study

开始日期2026-01-01

申办/合作机构

中山大学附属第一医院

100 项与胸腺法新相关的临床结果

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100 项与胸腺法新相关的转化医学

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100 项与胸腺法新相关的专利（医药）

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1,072

项与胸腺法新相关的文献（医药）

2026-03-04·IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Thymosin α1 improves the outcomes of patients with hepatitis B virus-related acute-on-chronic liver failure by restoring immune balance

Article

作者: Zhang, Jing ; Lei, Zi-ying ; Lin, Bing-liang ; Wu, Li-li ; Chen, Jun-feng ; Wang, Jia-lei ; Li, Zhi-hui ; Cao, Hui-juan ; Hu, Zhao-xia ; Meng, Shi-bo ; Zhu, Yuan-qiang

BACKGROUND:

Thymosin α1 (Tα1) has been shown to improve survival in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), but its immunomodulatory mechanisms remain unclear. This study investigated how Tα1 restores immune homeostasis to confer a survival benefit in these patients.

METHODS:

In this open-label, randomized controlled trial (NCT03082885), 73 patients with HBV-ACLF received either standard medical therapy (SMT, n = 38) or SMT plus Tα1 (n = 35). Peripheral blood immune cell subsets were analyzed by flow cytometry and serum cytokine levels were measured by ELISA. Patients were stratified by 90-day transplant-free survival.

RESULTS:

Patients who survived at 90 days exhibited a higher proportion of effector T (TE) cells and lower levels of regulatory T cells (Tregs) at baseline compared to non-survivors. Survivors also had significantly higher initial levels of pro-inflammatory cytokines (IL-6, TNF-α, IFN-γ) and lower levels of TGF-β. Over time, survivors showed a gradual decline in inflammatory markers, whereas non-survivors developed a progressive inflammatory storm. Tα1 treatment significantly increased 90-day transplant-free survival and was associated with reduced frequencies of Tregs and CD226^low/- Treg subsets at weeks 4-8. Tα1 also moderated the late-stage hyperinflammatory response without compromising early immune activation.

CONCLUSIONS:

Tα1 improves clinical outcomes in HBV-ACLF by rebalancing the immune response-mitigating excessive inflammation and preventing immune paralysis by modulating T-cell differentiation and cytokine production, thereby breaking the cycle of hyperinflammation and immunosuppression that characterizes ACLF progression.

2026-03-01·Drug information journal

Drug Repurposing in Oncology: A Strategic Pathway to Unlocking New Therapeutic Potential

Review

作者: Hamza, Anas ; Shaik, Rahaman ; Begum, Shireen ; Laddika, Sai Geethika ; Unnisa, Madiha ; Sarwar, Syeda Fatima

The growing number of cancer cases and deaths highlights the urgent need for innovative treatment approaches. One technique that has lately been recognized as having potential to improve the existing cancer immunotherapy treatment is drug repurposing. By utilizing previously studied molecules that have safety data yet provide superior solutions beyond those of the conventional treatments, it will essentially speed up medication discovery. By influencing the tumor microenvironment, encouraging T cell activation, and thwarting resistance mechanisms, repurposed medications may increase the efficacy of immune checkpoint inhibitors (ICIs). Notable medications include RANKL inhibitors, which boost immune cell responses; TGF-β inhibitors, which improve T cell infiltration; and metformin, which activates cytotoxic T lymphocytes. Other substances, such as GM-CSF and thymosin α1, have also been demonstrated to enhance antitumor immunity in a number of ways by encouraging T-cell activity and dendritic cell maturation. On the other hand, aspirin may enhance immune checkpoint inhibitors by blocking the immunological milieu that tumors produce. Even with the encouraging outcomes of preclinical research and continuing clinical trials, there are still a number of obstacles to overcome in order to optimize dosage strategies, reduce the possibility of off-target effects, and navigate the intricate regulatory environment. Future developments in personalized medicine and artificial intelligence may increase the efficacy of drug repurposing in cancer treatment. To fully realize the potential of repurposed medications in enhancing the results for cancer patients, interdisciplinary cooperation between the academic community, business leaders, and regulatory bodies will be required.

2026-01-21·Recent advances in anti-infective drug discovery

A Patent Review on the Use of Thymosin Peptides Against Viruses

Article

作者: Deshpande, Nishad ; Khode, Alok ; Shaikh, Shabib Ahmed

Abstract::

Thymosins are a group of immunomodulatory peptides secreted by the thymus. They play an important role in immune function by inducing T-cell expression and inhibiting viral replication. In light of the COVID-19 pandemic caused by coronavirus, there has been renewed interest in their activity, resulting in a revival of patents claiming the use of thymosin to combat coronavirus. This article reviews patents on the therapeutic application of thymosin peptides against viruses. Conventionally, thymosin is administered via injection or infusion; however, recent research has explored alternative routes, including oral formulations. Thymosin administration is used to complement antiviral drug treatments. Similarly, recent antiviral regimens against SARS-CoV-2 may be supplemented with thymosin based on its proven immunopotentiating activity.

项与胸腺法新相关的新闻（医药）

2026-04-30

·北京医学感染与传染研究

生物医学中心 - 医学 24卷 1期（1-4月）（2026年4月30日更新）

BMC Medicine [Jour] AND 24[volume] AND 1[issue] 生物医学中心 - 医学 24卷 1期 https://link.springer.com/journal/12916/volumes-and-issues/24-1 278 articles in this issue Efficacy and long-term engagement of a WeChat-integrated modality versus a traditional quitline on smoking cessation in China: a randomised controlled trial 微信整合模式与传统戒烟热线在中国戒烟中的疗效及长期参与度：一项随机对照试验 Shuilian ChuDi ZhangLirong Liang Research 21 March 2026 Article: 278 A culturally-safe primary care intervention for migrant/refugee women suffering domestic violence and abuse: HARMONY—a pragmatic cluster randomised controlled trial 针对遭受家庭暴力和虐待的移民/难民妇女的文化安全初级护理干预措施：HARMONY——一项实用性整群随机对照试验 Angela J. TaftFelicity YoungGene Feder Research 21 March 2026 Article: 277 Development, integration, retention, and career progression of physician associates/assistants in UK NHS hospitals and clinical teams: a multiple-case qualitative study 英国国家医疗服务体系（NHS）医院及临床团队中医师助理/协理医师的发展、整合、留任及职业晋升：一项多案例定性研究 Yingxi ZhaoRhys SwainstonThe ROADMAP-PA collaborator group Research 20 April 2026 Article: 276 Compound climate extreme events and associated health impacts: a scoping review 复合气候极端事件及其相关健康影响：一项范围性综述 Shifali MathewsCaitlin WalkerJaime Madrigano Research 20 March 2026 Article: 275 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Smoking history, eligibility for lung cancer screening and risk of death by lung cancer or other causes -- a longitudinal, time-variable analysis of the EPIC-Heidelberg cohort 吸烟史、肺癌筛查资格以及死于肺癌或其他原因的风险——对EPIC-海德堡队列的纵向、时变分析 Yue ChenSrimanti DuttaRudolf Kaaks Research 28 April 2026 Article: 274 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Cortical functional hierarchy disruption following subcortical stroke 皮质功能层级在皮层下卒中后的破坏 Ke WuGang LiuGaolang Gong Research 19 March 2026 Article: 273 Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization 利用孟德尔随机化方法表征遗传易感性对自身免疫性疾病患者妊娠结局的影响 Elisabeth AitonNancy S. McBrideMaria Carolina Borges Research 19 March 2026 Article: 272 Dystrophin-gene mutation location influences severity of electroretinogram defects in mouse models of Duchenne muscular dystrophy 杜氏肌营养不良症小鼠模型中，肌营养不良蛋白基因突变位置对视网膜电图缺陷严重程度的影响 André Maurício Passos LiberMirella BarboniCyrille Vaillend Research 25 April 2026 Article: 271 Personalizing the treatment of head and neck cancer in vitro: The 3D-OTC model 体外个性化治疗头颈部肿瘤：三维器官芯片（3D-OTC）模型 Fabian StögbauerTobias WeiserBarbara Wollenberg Research 25 April 2026 Article: 270 Part of 1 collection:Organoids: connecting molecular insights and clinical practice 所属专题合集：类器官：连接分子见解与临床实践 Risk factor profiles for infections in individuals with type 2 diabetes: a prospective cohort study 2型糖尿病患者感染的风险因素特征：一项前瞻性队列研究 Han-Cheng YuJi-Juan ZhangYun-Fei Liao Research 18 March 2026 Article: 269 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Cause-specific years of life lost attributable to non-optimal body mass index by county, sex, race, and ethnicity in the USA, 2000–2019: a systematic analysis of health disparities 2000-2019年美国按县、性别、种族和民族划分的非最佳体重指数导致的特定原因寿命损失年数：一项关于健康差异的系统分析 GBD US Health Disparities CollaboratorsFarah MouhannaLaura Dwyer-Lindgren Research 18 March 2026 Article: 268 Global and regional prevalence, burden, and risk factors for MASLD in children and adolescents aged 5 to 24years: a systematic review, meta-analysis, and modeling study 全球和区域5至24岁儿童和青少年代谢相关脂肪性肝病（MASLD）的患病率、负担及风险因素：一项系统综述、荟萃分析和建模研究 Yunfei LiuShan CaiSusan M. Sawyer Research 18 March 2026 Article: 267 Relative leukocyte telomere length and the risk of lung cancer progression in individuals with pulmonary nodules 相对白细胞端粒长度与肺结节患者肺癌进展风险的关系 Yuanyuan WuDong SunFeifei Cheng Research 18 March 2026 Article: 266 Effects of Tai Chi combined with transcranial direct current stimulation on pain in knee osteoarthritis: a randomized controlled neuroimaging trial 太极拳结合经颅直流电刺激对膝骨关节炎疼痛的影响：一项随机对照神经影像学试验 Xuefeng LiuTong TangJing Tao Research 17 March 2026 Article: 265 DNA hypermethylation of choline kinases drives blockage of choline-phosphatidylcholine biosynthesis: lipidomic biomarkers and epigenetic insights of hepatic steatosis induced by arsenic 胆碱激酶DNA高甲基化驱动胆碱-磷脂酰胆碱生物合成受阻：砷诱导的肝脂肪变性的脂质组学生物标志物及表观遗传学见解 Qiwen FuQi WangLu Ma Research 17 March 2026 Article: 264 Dynamics of Mpox epidemics by the interplay of COVID-19 pandemic in Africa 非洲猴痘（Mpox）流行与新冠肺炎（COVID-19）大流行相互作用下的猴痘流行病学动态 Oyewole K. OyedeleNifarta P. AndrewAlash’le Abimiku Research 17 March 2026 Article: 263 Part of 1 collection:Mpox: Epidemiology, prevention, and treatment 所属专题合集：猴痘：流行病学、预防和治疗 SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection SPP1高表达成纤维性巨噬细胞介导保护性纤维化重塑并促进高血压相关主动脉夹层的血管稳定性 Shuai ZhaoXiumeng HuaJiangping Song Research 16 March 2026 Article: 262 Longitudinal associations between body fat mass and cardiovascular outcomes among Chinese children: mediation by cardiometabolic risk factors 中国儿童身体脂肪量与心血管结局之间的纵向关联：通过心脏代谢风险因素的中介作用 Hui YangQin LiuBo Xi Research 16 March 2026 Article: 261 The timing of the commencement of pulmonary rehabilitation in hospitalized patients with acute exacerbation of COPD: a systematic review and network meta-analysis 住院慢性阻塞性肺疾病急性加重患者开始肺康复治疗的时机：一项系统综述和网络荟萃分析 Peilin JiaHailong ZhangLongyu Wang Research 16 March 2026 Article: 260 Correction: Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study 更正：膀胱癌流行病学和营养决定因素（BLEND）国际研究中蔬菜摄入量与膀胱癌风险的关系 Evan Yi-Wen YuAnke WesseliusMaurice P. Zeegers Correction 22 April 2026 Article: 259 Comparative efficacy of neoadjuvant short-course versus long-course radiotherapy-based regimens with or without immunotherapy for locally advanced pMMR rectal cancer: a systematic review and network meta-analysis 基于放疗的新辅助短疗程与长疗程治疗方案（联合或不联合免疫治疗）对局部晚期错配修复功能正常（pMMR）型直肠癌的疗效比较：一项系统综述与网状荟萃分析 Liqing LiXiaoyao MengTingshi Su Research 14 March 2026 Article: 258 Association between bariatric surgery and long-term ability to perform household tasks in the Swedish Obese Subjects study: a controlled prospective cohort study 瑞典肥胖受试者研究：减肥手术与长期从事家务能力之间的关联——一项对照前瞻性队列研究 Petra BrembeckJohanna C. Andersson-AssarssonPer-Arne Svensson Research 18 April 2026 Article: 257 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减重干预措施及其健康影响 The role of male foetal sex on maternal and neonatal outcomes in pregnancies complicated by gestational diabetes—secondary analysis of a randomised placebo controlled clinical trial of metformin in gestational diabetes (EMERGE) 男性胎儿性别对妊娠期糖尿病合并妊娠的母婴预后的影响——妊娠期糖尿病二甲双胍随机对照安慰剂临床试验（EMERGE）的二次分析 Christine NewmanAlberto Alvarez-IglesiasFidelma Dunne Research 12 March 2026 Article: 256 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠期糖尿病的诊断与管理 Downregulated lysyl oxidase in plasma extracellular vesicles: a biomarker linked to brain metastasis risk in lung adenocarcinoma 血浆细胞外囊泡中赖氨酰氧化酶表达下调：与肺腺癌脑转移风险相关的生物标志物 Jing LiYu PeiYi Liu Research 12 March 2026 Article: 255 The influence of age-dependent susceptibility on RSV transmission dynamics and immunisation population-level impact 年龄依赖性易感性对呼吸道合胞病毒（RSV）传播动力学及免疫接种人群层面影响的研究 Chenkai ZhaoYuhe ZhangHarish Nair Research 11 March 2026 Article: 254 A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress 一株人源拟杆菌属菌株可减轻社会挫败诱导应激大鼠模型的抑郁样行为 Marisol I. DothardMariaelena CaboniPhilip Strandwitz Research 10 March 2026 Article: 253 Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing 童年和成年期的不良事件均与衰老的分子、临床和功能标志物相关 Monica AasThole H HoppenJulian Mutz Research 28 April 2026 Article: 252 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Genetic predisposition to high BMI, ultra-processed food consumptions in childhood, and adiposity in young adulthood: a 17-year prospective cohort study of 3061 individuals 高BMI遗传易感性、儿童期超加工食品摄入与成年早期肥胖：一项对3061例个体进行的为期17年的前瞻性队列研究 Ziyi ZhouQiaosen ChenFrederick K. Ho Research 16 April 2026 Article: 251 Enhanced predictive performance of artificial intelligence in individualized ovarian stimulation of in vitro fertilization: a retrospective cohort study 人工智能在体外受精个体化卵巢刺激中的预测性能提升：一项回顾性队列研究 Guiquan WangMinyue TangYimin Zhu Research 10 March 2026 Article: 250 PCDSOS: a novel clinical predictive tool for screening primary ciliary dyskinesia in adult bronchiectasis patients—a multicenter derivation and external validation study PCDSOS：一种用于筛查成人支气管扩张症患者原发性纤毛运动障碍的新型临床预测工具——一项多中心推导及外部验证研究 Wangji ZhouLin WangXinlun Tian Research 10 March 2026 Article: 249 Detection rate and mutational landscape in extracranial arteriovenous malformations: a cohort study 颅外动静脉畸形的检出率及突变谱：一项队列研究 Vanessa F. SchmidtDenny Schanzefor the APOLLON Investigators Research 16 April 2026 Article: 248 Kinetics of antibodies and risk of respiratory syncytial virus infection: a longitudinal cohort in Taizhou City, eastern China 抗体动力学与呼吸道合胞病毒感染风险：中国东部台州市的一项纵向队列研究 Qiang WangDavid HodgsonWeibing Wang Research 09 March 2026 Article: 247 Cell therapy strategies for organ regeneration 器官再生的细胞治疗策略 L. PapamichailL. J. W. van der LaanM. J. Hoogduijn Review 25 February 2026 Article: 246 Transcutaneous spinal cord stimulation combined with robot-assisted gait training to improve mobility and balance in spinal cord injury: intramuscular electromyography as a biomarker for functional recovery 经皮脊髓电刺激联合机器人辅助步态训练改善脊髓损伤患者的行动能力和平衡能力：肌内肌电图作为功能恢复的生物标志物 Abdul RashadHe XijingMuhammad Asif Registered Report 09 March 2026 Article: 245 Neoadjuvant camrelizumab combined with radiotherapy as a chemotherapy-sparing approach for resectable locally advanced esophageal squamous cell carcinoma: a phase II clinical trial (ESOCORT-NIRT) 新辅助卡瑞利珠单抗联合放疗作为可切除局部晚期食管鳞癌的免化疗方案：一项II期临床试验（ESOCORT-NIRT） Maohui ChenYizhou HuangBin Zheng Research 09 March 2026 Article: 244 FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy FLASH放疗在保持抗肿瘤疗效的同时维持全身及组织稳态 Giulia FuriniEduarda Mota da SilvaMargherita Maffei Research 26 February 2026 Article: 243 fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial 功能磁共振成像引导的V1区靶向重复经颅磁刺激改善青少年及青年双相情感障碍患者的抑郁症状：一项双盲随机对照试验 Xudong ZhaoHetong ZhouMinmin Wang Research 07 March 2026 Article: 242 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童及青少年精神病学 Impairment of brain short association fibers across clinical stages in amyotrophic lateral sclerosis: a new biomarker mirroring disease progression 肌萎缩侧索硬化症临床各阶段脑短联结纤维受损情况：一种反映疾病进展的新型生物标志物 Nao-Xin HuangZi-Wei CaiHua-Jun Chen Research 06 March 2026 Article: 241 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Social frailty and the risk of progression from health to physical, psychological, and cognitive multimorbidity: a prospective multi-cohort study 社会脆弱性与从健康状态进展至身体、心理及认知多病共存状态的风险：一项前瞻性多队列研究 Yaguan ZhouHtet Lin HtunYi Guo Research 06 March 2026 Article: 240 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用 Association between early life constituent-specific PM2.5 exposure and child development and the moderating role of greenness: a nationwide study in China 中国全国范围内早期生命特定成分PM2.5暴露与儿童发育的关联及绿地调节作用的研究 Ruili LiXiaoguo ZhengXiaoning Lei Research 06 March 2026 Article: 239 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童及青少年精神病学 Intravenous thrombolysis versus standard medical therapy in minor stroke patients with large vessel severe stenosis or occlusion: a systematic review and meta-analysis 静脉溶栓与标准药物治疗轻型卒中合并大血管重度狭窄或闭塞患者的系统综述与荟萃分析 Tianhao ZhangLin TongZhigang Liang Research 06 March 2026 Article: 238 Long-term risk of offspring type 1 and type 2 diabetes following maternal gestational diabetes mellitus: a nationwide birth cohort study with 10-year follow-up 母亲妊娠期糖尿病后子女患1型和2型糖尿病的长期风险：一项为期10年随访的全国出生队列研究 Joon Ho MoonHan Na JungSung Hee Choi Research 06 March 2026 Article: 237 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠期糖尿病的诊断与治疗 Parental income in childhood and health outcomes across age groups: a register-based study from Norway 童年期父母收入与各年龄段健康结局：一项基于挪威登记数据的研究 Bjørn-Atle RemeHans Fredrik SundeJonathan Wörn Research 06 March 2026 Article: 236 AI-based quality control was associated with improved fetal ultrasound image quality in low-resource settings: a real-world multicenter study from West China 基于人工智能的质量控制可改善低资源环境下胎儿超声图像质量：一项来自中国西部的现实多中心研究 Jianxin ZhaoYao TangYong Huang Research 06 March 2026 Article: 235 Reply to: Intraoperative use of sodium oxybate to prevent post-operative delirium in older patients undergoing major orthopedic surgery 回复：术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄 Meiying CuiHang XuePing Zhao Matters Arising 13 April 2026 Article: 234 Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis 无假设的循环代谢组学评估为肌萎缩侧索硬化症中能量底物可用性的细胞特异性作用提供见解 Elham AlhathliJohnathan Cooper-KnockPamela J. Shaw Research 06 March 2026 Article: 233 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Intraoperative use of sodium oxybate to prevent postoperative delirium in older patients undergoing major orthopedic surgery 术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄 Fu-Shan XueDan-Feng WangXiao-Chun Zheng Matters Arising 13 April 2026 Article: 232 Statin therapy and stroke risk in patients with hypercholesterolaemia: a population-based longitudinal study using electronic health records in South London 他汀类药物治疗与高胆固醇血症患者卒中风险：一项基于南伦敦电子健康记录的纵向人群研究 Marc DelordAbdel Douiri Research 05 March 2026 Article: 231 Thermal ablation versus hepatectomy for solitary colorectal liver metastases up to 5 cm: a multicenter target trial emulation on safety, efficacy, and cost-effectiveness 热消融与肝切除术治疗直径达5厘米的孤立性结直肠癌肝转移：一项关于安全性、疗效及成本效益的多中心目标试验模拟研究 Jianming LiLu LiPing Liang Research 05 March 2026 Article: 230 Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetes 为何高胰岛素血症不利于减重：来自1型糖尿病的见解 Stephan MartinKerstin KempfHubert Kolb Debate 10 April 2026 Article: 229 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减重干预措施及其健康影响 Interventions to prevent and treat multiple long-term conditions and their consequences across the life course: concepts and definitions 预防和治疗多种长期疾病及其在生命周期中后果的干预措施：概念与定义 Miles D. WithamGuruprasad P. AithalThe Multiple Long-Term Conditions Cross-NIHR Collaboration Interventions and Prevention Workstream Forum 10 April 2026 Article: 228 Effectiveness of nirmatrelvir/ritonavir and molnupiravir on post-COVID diabetes risk among an older adult cohort: a target trial emulation study 奈玛特韦/利托那韦和莫努匹韦对老年人群新冠后糖尿病风险的影响：一项目标试验模拟研究 Zihao GuoYuchen WeiKa Chun Chong Research 17 March 2026 Article: 227 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与传染病 Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS 瑞典基于人群的队列研究AMORIS中铁缺乏与痴呆风险的证据 Mozhu DingAlexandra WennbergKarin Modig Research 08 April 2026 Article: 226 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Effects of ultrasound-guided stellate ganglion block in poststroke bulbar palsy: a double-blind placebo-controlled trial 超声引导下星状神经节阻滞对脑卒中后球麻痹的影响：一项双盲安慰剂对照试验 Hongji ZengWeihong ZhangXi Zeng Research 04 March 2026 Article: 225 Dual-utility ctDNA in diffuse large B-cell lymphoma: integrated genotyping unveils minimal residual disease dynamics and subtype-specific clonal evolution 双用途循环肿瘤DNA在弥漫性大B细胞淋巴瘤中的应用：整合基因分型揭示微小残留病灶动态变化及亚型特异性克隆演变 Jin-Hua LiangYi-Fan WuWei Xu Research 04 March 2026 Article: 224 Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2pathogenic variant carriers: a prospective cohort study BRCA1和BRCA2致病性变异携带者患非乳腺、非卵巢癌的风险：一项前瞻性队列研究 Ruotong YangRobert J. MacInnisShuai Li Research 04 March 2026 Article: 223 Cardiovascular outcomes of intensive blood pressure control in patients with and without metabolic dysfunction-associated fatty liver disease: post hoc analysis of the CRHCP trial 在伴有和不伴有代谢功能障碍相关脂肪性肝病的患者中，强化血压控制的心血管预后：CRHCP试验的事后分析 Songyue LiuYangzhi YinXiaofan Guo Research 04 March 2026 Article: 222 The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations 慢性阻塞性肺疾病和吸入性糖皮质激素在心血管-肾脏-代谢人群主要不良心血管事件中的作用 Anne E. IoannidesEmily L. GraulJennifer K. Quint Research 04 March 2026 Article: 221 Ethnic differences in the burden of cardiovascular disease risk factors among adult residents of London: the TOGETHER study 伦敦成年居民心血管疾病风险因素负担的种族差异：TOGETHER研究 Fotios BarkasMalo DirouKausik K. Ray Research 03 March 2026 Article: 220 Development of a novel prognostic assessment tool for recurrent respiratory papillomatosis 复发性呼吸道乳头瘤病新型预后评估工具的开发 Satoshi YamadaTaro IkegamiKiyoshi Misawa Research 16 April 2026 Article: 219 Response to: Matters Arising in relation to “Evaluating agreement between individual nutrition randomised controlled trials and cohort studies – a meta-epidemiological study” 针对“评估个体营养随机对照试验与队列研究之间的一致性——一项元流行病学研究”的相关问题探讨 Julia StadelmaierGina BantleLukas Schwingshackl Matters Arising 09 April 2026 Article: 218 Concordance between nutritional cohorts and randomized trials: biological confirmation or statistical consequence? A re-analysis of Stadelmaier et al. 营养队列研究与随机试验之间的一致性：生物学证实还是统计学结果？对Stadelmaier等人的研究再分析 Matthew CalkinsIsaac NúñezAdrian Soto-Mota Matters Arising 09 April 2026 Article: 217 Multimorbidity patterns and 15-year trajectories of physical performance: a population-based study 多病共存模式与15年身体机能变化轨迹：一项基于人群的研究 Francesco PalmeseDavide Liborio VetranoFederico Triolo Research 25 March 2026 Article: 216 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 The need for clinical studies assessing whether weight loss improves functional outcome after stroke in diabetes 评估减肥是否改善糖尿病患者中风后功能预后的临床研究需求 Ellen VercalsterenMichael V. MazyaCesare Patrone Debate 24 March 2026 Article: 215 Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice 靶向STE20型激酶MST3可改善小鼠代谢功能障碍相关脂肪性肝炎，且不影响肝细胞癌的发展 Jingjing ZhangXiangdong GongyeMargit Mahlapuu Research 24 March 2026 Article: 214 Multimorbidity patterns and the subsequent risk of albuminuria: findings from the Stockholm Creatinine Measurements (SCREAM) project 多病共存模式与后续白蛋白尿风险：来自斯德哥尔摩肌酐测量（SCREAM）项目的研究结果 Giorgi BeridzePatrick B. MarkJuan-Jesus Carrero Research 24 March 2026 Article: 213 Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma 胶质母细胞瘤神经元微环境中髓系来源的免疫抑制对嵌合抗原受体T细胞的影响 Junyi ZhangJasmin von EhrYahaya A. Yabo Research 13 March 2026 Article: 212 Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization 基因预测的白细胞介素-6和肿瘤坏死因子信号通路与结直肠癌患者死亡率之间的关联：一项双样本孟德尔随机化研究 Martina BoukaKatharina NimptschTobias Pischon Research 06 March 2026 Article: 211 Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS 血管生成素样系统紊乱将肌萎缩侧索硬化症中的脂质稳态与下丘脑功能障碍关联起来 Sruthi Sankari KrishnamurthyAdriana Zardini BuzattoFrancesco Roselli Research 03 March 2026 Article: 210 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Day+30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML 移植后第30天通过高灵敏度PCR-NGS检测微小残留FLT3-ITD可预测急性髓系白血病（AML）复发风险并指导移植后维持治疗 Shan JiangDan FengErlie Jiang Research 03 March 2026 Article: 209 Early childhood weight gain and alanine aminotransferase at age 8: an adjunct study of the Japan Environment and Children’s Study 幼儿期体重增长与8岁时丙氨酸氨基转移酶水平：日本环境与儿童研究的一项辅助研究 Naw Awn J-PKeiko YamasakiNarufumi Suganuma Research 03 March 2026 Article: 208 Anti-CD19 chimeric antigen receptor T-cell therapy for relapsed or refractory Philadelphia chromosome-positive B cell acute lymphoblastic leukemia: a multicenter retrospective study 抗CD19嵌合抗原受体T细胞疗法治疗复发或难治性费城染色体阳性B细胞急性淋巴细胞白血病：一项多中心回顾性研究 Jinglei YuFengmei SongGuoqing Wei Research 03 March 2026 Article: 207 Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics 通过单细胞和空间转录组学鉴定人类卵巢皮质中的冷敏感生态位及可靶向的FOS/AP-1程序 Fanghao GuoDi SunWen Li Research 03 March 2026 Article: 206 Neoadjuvant camrelizumab combined with metronomic chemotherapy in patients with advanced esophageal squamous cell carcinoma: a pilot randomized phase 2 trial 卡瑞利珠单抗联合节拍化疗新辅助治疗晚期食管鳞状细胞癌：一项随机2期初步试验 Zhiming ChenWenshuai LiJie Liu Research 03 March 2026 Article: 205 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症临床试验 Vericiguat for endothelial dysfunction and CRT response in non-responders: the VERCET prospective observational study 维利西呱治疗无反应者的内皮功能障碍和心脏再同步化治疗（CRT）反应：VERCET前瞻性观察研究 Celestino SarduLudovica Vittoria MarfellaRaffaele Marfella Research 03 March 2026 Article: 204 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病和心律失常 Assessment of antibody responses to Anopheles SG6-P1 and Aedes N-term 34kDa salivary peptides: a randomised human-challenge trial of controlled exposures to vector bites 评估针对按蚊SG6-P1和伊蚊N端34 kDa唾液肽的抗体反应：一项对媒介叮咬进行可控暴露的随机人体挑战试验 Victor ChaumeauEllen A. KearneyFreya J. I. Fowkes Research 02 March 2026 Article: 203 Is random biopsy necessary for normal esophageal mucosa during chromoendoscopy? Evidence from a population-based cohort study 在色素内镜检查过程中，对于正常食管黏膜是否有必要进行随机活检？一项基于人群的队列研究证据 Wenlei YangMengfei LiuYang Ke Research 02 March 2026 Article: 202 Sinusoidal cell–derived biomarker scores predict diagnosis and prognosis in chronic liver disease 窦状隙细胞来源的生物标志物评分可预测慢性肝病的诊断和预后 Sergi Guixé-MuntetAnabel Fernández-IglesiasJordi Gracia-Sancho Research 28 February 2026 Article: 201 Anticholinergic drug burden and incident cardiovascular events: a population-based study 抗胆碱能药物负担与新发心血管事件：一项基于人群的研究 Nanbo ZhuMaria EriksdotterHong Xu Research 28 February 2026 Article: 200 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study 从儿童期到成年期体重指数（BMI）变化对亚临床心血管结局影响的敏感期：一项为期36年的前瞻性队列研究 Hui YangTongshuai GuoJianjun Mu Research 27 February 2026 Article: 199 Feasibility and preliminary efficacy of an art-making program to manage fear of cancer recurrence (AM-I-FCR) in lung cancer patients: a randomized controlled pilot study 艺术创作项目（AM-I-FCR）管理肺癌患者对癌症复发恐惧的可行性与初步疗效：一项随机对照试点研究 Jialing LinZhixuan KangFeifei Huang Research 27 February 2026 Article: 198 Unveiling disparities in lung cancer care: a joint spatio-temporal analysis of multidisciplinary meeting presentation, supportive care screening, and diagnostic timeliness in Victoria 揭示肺癌诊疗差异：维多利亚州多学科会诊展示、支持性护理筛查及诊断及时性的联合时空分析 Getayeneh Antehunegn TesemaRob G. StirlingArul Earnest Research 27 February 2026 Article: 197 Transcriptome-based high-frequency recurrence index predicts frequent recurrence in non-muscle-invasive bladder cancer after Bacillus Calmette-Guérin therapy 基于转录组的高频复发指数可预测卡介苗治疗后非肌层浸润性膀胱癌的频繁复发情况 Seung-Woo BaekYoung Joon ByunSeok Joong Yun Research 27 February 2026 Article: 196 Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study 出生体重对健康老龄化的终身影响及后续途径：一项孟德尔随机化研究 Lijie KongChun DouTiange Wang Research 25 February 2026 Article: 195 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Routine inflammatory indices modify clonal hematopoiesis-related prognostic risk in patients undergoing percutaneous coronary intervention: a real-world cohort study 常规炎症指标改变接受经皮冠状动脉介入治疗患者的克隆性造血相关预后风险：一项现实队列研究 Xuxiang ShenYing SongXiangfeng Lu Research 25 February 2026 Article: 194 Health experiences and outcomes of autistic and non-autistic adults with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder 自闭症和非自闭症成年孤独症患者及非孤独症患者中患有高迁移率埃勒斯-丹洛斯综合征和高迁移率谱系障碍者的健康体验和预后 Catherine J. CromptonThemis N. EfthimiouKathryn M. Berg Research 25 February 2026 Article: 193 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Effects of non-pharmacological interventions on sleep quality in older adults: a systematic review and network meta-analysis of randomized controlled trials 非药物干预措施对老年人睡眠质量影响：基于随机对照试验的系统综述和网络荟萃分析 Jia SongHeng DongShangfeng Tang Research 25 February 2026 Article: 192 Cortical excitability mapping stratifies neurobiological subtypes of schizophrenia with genetic and molecular signatures 皮质兴奋性映射对具有遗传和分子特征的精神分裂症神经生物学亚型进行分层 Sixuan GuoYu ZhaoQiyong Gong Research 25 February 2026 Article: 191 Minimum 18-week chemotherapy improves survival in locally advanced rectal cancer after neoadjuvant radiotherapy: a post hoc analysis of the STELLAR trial 新辅助放疗后局部晚期直肠癌患者接受至少18周化疗可改善生存率：STELLAR试验的事后分析 Tongzhen XuHuiying MaJing Jin Research 25 February 2026 Article: 190 Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria 在莫桑比克患疟疾的儿童中，蠕虫共感染可减轻临床、寄生虫学和免疫学转归 Inocência CuambaRebeca SantanoCarlota Dobaño Research 31 March 2026 Article: 189 Effectiveness of group-based art interventions for late-life depression: a systematic review and meta-analysis of randomized controlled trials 团体艺术干预对老年抑郁症的疗效：一项针对随机对照试验的系统综述和荟萃分析 Mohamad AzhdarlooRaziyeh AtaeiAbouzar Nazari Research 24 February 2026 Article: 188 The associations of consultant sex on herding‑like prescribing behaviour: evidence from a web-based experiment with female primary care physicians in England 顾问性别对从众式处方行为的影响：来自一项针对英格兰女性初级保健医生的网络实验的证据 Sandro Tiziano StoffelMatthias SchwenkglenksBerna Cennet Özdemir Research 24 February 2026 Article: 187 Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients 三羧酸循环代谢物指数预测急性心肌梗死患者的不良预后 Ye WangPengyan WuBo Yu Research 24 February 2026 Article: 186 Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids 靶向癌症干细胞可预测腹水来源的卵巢癌类器官的反应并逆转化疗耐药性 Xiaoli ZhangWen ZhangHuiqin Guo Research 24 February 2026 Article: 185 Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk 青少年神经对压力的易感性：一项使用抑郁风险多连接组评分进行的纵向研究 Yuan LiuMeijuan LiJie Li Research 24 February 2026 Article: 184 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Classification of ALS molecular subtypes: a literature review on machine learning applications and their clinical value 肌萎缩侧索硬化症分子亚型分类：机器学习应用及其临床价值的文献综述 John K. JammalEsteban A. GomezAlfredo Iacoangeli Review 23 February 2026 Article: 183 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Can we protect refugee children from mental health problems?— a scoping review of modifiable factors to inform preventive interventions 我们能否保护难民儿童免受心理健康问题困扰？——一项旨在为预防性干预提供信息的可改变因素的范围性综述 Rita GonçalvesM J MarquesSónia Dias Research 23 February 2026 Article: 182 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 The Trial Bank initiative to promote trustworthy living evidence for medication safety (PROMISE) of children: design and pilot validation 促进儿童用药安全可信实时证据（PROMISE）的试验库计划：设计与初步验证 Chang XuSuhail A. DoiPROMISE Collaborative Research Network Research 21 February 2026 Article: 181 Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania 液体活检是否为诊断坦桑尼亚儿童和青年成人伯基特淋巴瘤的一种具有成本效益的方法？一项卫生经济学评估 Jingjing JiangLiz MorrellAI-REAL Consortium Research 21 February 2026 Article: 180 The influence of immunohistochemistry-based subtypes on overall survival in breast cancer spine metastases: a systematic review and meta-analysis 基于免疫组织化学的亚型对乳腺癌脊柱转移总生存期的影响：一项系统综述和荟萃分析 Fon-Yih TsuangYun-Heng LiChung Liang Chai Research 21 February 2026 Article: 179 Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children 产前接触母体哮喘及哮喘药物与神经发育结局的关系：一项针对179,024例儿童的人群队列研究 Lama A. ShakhshirSarjit SinghMichael Fleming Research 20 February 2026 Article: 178 First-in-human phase 1/2a study of T3011, an oncolytic HSV expressing IL-12 and PD-1 antibody, administered via intratumoral (IT) injection as monotherapy in advanced solid tumors, including recurrent or metastatic HNSCC T3011（一种表达IL-12和PD-1抗体的溶瘤性单纯疱疹病毒）首次人体1/2a期研究：通过瘤内（IT）注射作为单一疗法治疗包括复发或转移性头颈部鳞状细胞癌在内的晚期实体瘤 Dongmei JiWenmin FuXichun Hu Research 20 February 2026 Article: 177 Expanding access to cerebrovascular imaging with routine MRI for pre-surgical assessment of intracranial tumor patients: an AI model development and multi-center validation study 利用常规MRI扩大脑血管成像在颅内肿瘤患者术前评估中的应用范围：一项人工智能模型开发与多中心验证研究 Chaoyue ChenZhouyang HuangJianguo Xu Research 20 February 2026 Article: 176 Changing landscape of physical fitness and urban–rural inequalities: evidence from 1.2 million children and adolescents over 20 years of urbanization 20年城市化进程中120万例儿童和青少年体质健康状况及城乡差异的变化 Shan CaiJiaxin LiYi Song Research 19 February 2026 Article: 175 Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis 抗糖尿病前期药物在糖尿病前期患者中的疗效和安全性：一项贝叶斯网状荟萃分析 Yike WuZihan WangGuo Ma Research 19 February 2026 Article: 174 Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders Yuefeng YuChenyi WanNingjian Wang 意义未明的克隆性造血与新发精神障碍风险 Research 18 February 2026 Article: 173 Spatial characterization of intrahepatic fat deposition across steatotic liver disease subcategories: a multicenter study 脂肪性肝病各亚类中肝内脂肪沉积的空间特征：一项多中心研究 Yan-Ci ZhaoMin WangFeng Chen Research 18 February 2026 Article: 172 Pregnancy outcomes among medically complex populations with high risk of pregnancy mortality in Virginia: a retrospective observational study 弗吉尼亚州妊娠死亡高风险医学复杂人群的妊娠结局：一项回顾性观察研究 Michael J. GreenLauren G. AndersonJonas J. Swartz Research 18 February 2026 Article: 171 Maternal amino acid metabolites during pregnancy and preterm birth: results from two prospective cohort studies 孕期母体氨基酸代谢物与早产的关系：两项前瞻性队列研究的结果 Jingnan ChenYidan DongJu-Sheng Zheng Research 18 February 2026 Article: 170 Correction: Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications 更正：停用抗肥胖药物后体重的变化轨迹 Han WuWenjia YangLinong Ji Correction 25 March 2026 Article: 169 Physical activity patterns and cardiovascular disease risk in adults with overweight or obesity: a prospective cohort study 超重或肥胖成人身体活动模式与心血管疾病风险：一项前瞻性队列研究 Kai MuYanan QiaoBo Xi Research 16 February 2026 Article: 168 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减肥干预措施及其对健康的影响 Maternal migraine and offspring ADHD: triangulating the evidence 母亲偏头痛与后代多动症（ADHD）：多方证据综合分析 Yaxin LuoChristina DardaniEvie Stergiakouli Research 14 February 2026 Article: 167 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson’s disease 靶向NLRP3的自主性小干扰RNA（siRNA）递送系统：在帕金森病中的潜在意义 Lishan LinZhizong LiZhong Pei Research 12 February 2026 Article: 166 Lay descriptions of painful temporomandibular disorders—an international consensus proposal for Global Burden of Disease estimates 颞下颌关节紊乱病疼痛的通俗描述——全球疾病负担评估的国际共识提案 A. LövgrenP. LivP. Svensson Research 17 March 2026 Article: 165 Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study 可溶性肿瘤坏死因子受体1与tau蛋白病变、脑萎缩及认知功能下降的关联：一项纵向研究 Yutong ZhangLulu SunAlzheimer’s Disease Neuroimaging Initiative Research 11 February 2026 Article: 164 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Particulate matter and respiratory health in middle-aged and older adults: disentangling size-fractionated and constituent-specific effects under China’s clean-air policies 颗粒物与中老年人呼吸系统健康的关系：厘清中国净化空气政策下不同粒径及成分的特定影响 Yujing ChenZhaoyan LiuYu-ming Chen Research 11 February 2026 Article: 163 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Clinical impact and cost-effectiveness of vaccinating infants and adolescents against invasive meningococcal B disease in the Netherlands 荷兰为婴儿和青少年接种针对侵袭性脑膜炎球菌B病的疫苗的临床影响和成本效益 Thomas OttenMirjam KnolAnneke Steens Research 10 February 2026 Article: 162 Association between trajectories of sleep quality and postpartum depression: a group-based trajectory model and computer-simulated network analysis 睡眠质量轨迹与产后抑郁之间的关联：基于组别的轨迹模型和计算机模拟网络分析 Xiaoxiao MeiJinzhou YuZengjie Ye Research 10 February 2026 Article: 161 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Understanding Japan’s mortality advantage: a comparison of mortality in independent and dependent older adults in Japan and Sweden 解读日本在死亡率方面的优势：日本与瑞典独立生活及依赖他人生活老年人的死亡率比较 Shunsuke MurataMarcus EbelingKarin Modig Research 23 March 2026 Article: 160 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用 The Young Adult Sleep model: an evolving causal loop diagram of mental health dynamics 青年睡眠模型：心理健康动态演变的因果环路图 Jeroen F. UlemanRushd F. M. Al-ShamaNaja Hulvej Rod Research 16 March 2026 Article: 159 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma 基于抑瘤素M配体的CAR-T疗法对骨肉瘤显示出强大的抗肿瘤活性 Daniel FeinbergVinayak UppinReshmi Parameswaran Research 17 March 2026 Article: 158 Antimicrobial catheters coated with poly-L-lysine for the prevention of bacteriuria in adults requiring short-term catheterization: a multicenter randomized controlled trial 涂有聚-L-赖氨酸的抗菌导管预防短期导尿成人患者菌尿症：一项多中心随机对照试验 Xinfei LiJun LiuKai Zhang Research 09 February 2026 Article: 157 Penpulimab in combination with lenalidomide and R-GemOx regimen (R2-GemOx-PD1i) in relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm, phase 2 trial 派安普利单抗联合来那度胺和R-GemOx方案（R2-GemOx-PD1i）治疗复发或难治性弥漫性大B细胞淋巴瘤：一项多中心、单臂、2期试验 Jin-Hua LiangTong-Yao XingWei Xu Research 09 February 2026 Article: 156 Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus 数字孪生大脑揭示耳鸣异常脑动力学状态特异性刺激靶点 Jiaqi ZhangShuting HanTianzi Jiang Research 10 February 2026 Article: 155 The case for mandatory reporting to enable targets for healthy and environmentally sustainable food: means, motive and opportunity 强制报告实现健康且环境可持续食物目标的理由：方法、动机和机会 Rachel PecheyLauren BandySusan A. Jebb Debate 10 February 2026 Article: 154 Genetic insights into radiomic and proteomic changes under β1-blockers treatment in hypertensive heart disease and hypertrophic cardiomyopathy β1受体阻滞剂治疗高血压性心脏病和肥厚型心肌病时放射组学和蛋白质组学变化的遗传学见解 Zhe ChenYifan TangKai Xie Research 09 February 2026 Article: 153 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病与心律失常 Optimizing drug-resistant tuberculosis diagnosis: cost-effectiveness of rapid molecular and phenotypic assays in South Africa 优化耐药结核病诊断：南非快速分子和表型检测方法的成本效益分析 Ginenus FekaduTadesse TolossaWai Kit Ming Research 09 February 2026 Article: 152 Maternal smoking based on pre-birth health examination and risk of neurodevelopmental disorders in offspring: insights from a Korean mother–child cohort 基于产前健康检查探讨母亲吸烟与后代神经发育障碍风险的关系：来自韩国母婴队列研究的见解 Chan Soon ParkMoonyoung JangJun-Bean Park Research 11 March 2026 Article: 151 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Effects of ablation versus drug therapy on clinical outcomes and quality of life by frailty status in atrial fibrillation: a post hoc analysis of the CABANA trial 根据衰弱状态分析消融术与药物治疗对心房颤动患者临床预后和生活质量的影响：CABANA试验的事后分析 Lili WangYanguang LiYunlong Wang Research 07 February 2026 Article: 150 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病与心律失常 Quantifying lifetime risk for 1,401 infectious diseases across the diabetes spectrum using a Bayesian approach 采用贝叶斯方法量化糖尿病全病程中1401种传染病的终生风险 Boomer B. OlsenMartin Tristani-FirouziEdgar Javier Hernandez Research 07 February 2026 Article: 149 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与传染病 Risk assessment of asthma and allergic rhinitis in atopic dermatitis patients treated with biologics and JAK inhibitors: a systematic review and network meta-analysis of randomized controlled trials 对接受生物制剂和JAK抑制剂治疗的特应性皮炎患者罹患哮喘和过敏性鼻炎的风险评估：一项针对随机对照试验的系统综述和网络荟萃分析 Liling ZengTong ZhouJing Li Research 07 February 2026 Article: 148 Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma 布林西多福韦（brincidofovir）在外周T细胞和NK/T细胞淋巴瘤中的临床前活性 Jason Yongsheng ChanElizabeth Chun Yong LeeChoon Kiat Ong Research 06 February 2026 Article: 147 Genetic risk factors modulate the association between physical activity and colorectal cancer 遗传风险因素调节身体活动与结直肠癌之间的关联 Anita R. PeoplesMireia Obón-SantacanaVictor Moreno Research 05 February 2026 Article: 146 A neuroimaging biomarker for disease staging in clinically diagnosed Alzheimer’s disease 临床诊断阿尔茨海默病的疾病分期神经影像学标志物 Zhuangzhuang LiShaozhen YanYong Liu Research 05 February 2026 Article: 145 Association of GLP-1 receptor agonists with herpes risks in diabetes mellitus: a target trial emulation 胰高血糖素样肽-1（GLP-1）受体激动剂与糖尿病中疱疹风险的关联：一项目标试验模拟研究 Chi-Hsien HuangI-Hui ChiangJames Cheng-Chung Wei Research 31 December 2025 Article: 144 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial 局部晚期胃癌联合胸腺肽的新辅助免疫化疗：一项前瞻性临床试验 Hao XuFengyuan LiZekuan Xu Research 26 February 2026 Article: 143 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症的临床试验 Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis 临床医生在临床复查中检测急性脑膜炎后遗症：一项系统综述和荟萃分析 Luisa F. AlvizCarla Y. KimKiran T. Thakur Research 28 February 2026 Article: 142 Part of 1 collection:Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述合集 ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics ISG15驱动的免疫调节与乳腺癌转移中的肿瘤进展：来自单细胞和空间转录组学的见解 Hua ShaoHanlu TangYongqing Xu Research 04 February 2026 Article: 141 Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk 评估家族史和多基因风险评分对心代谢疾病风险的影响 Ebuka OnyenobiKnightess OyiboSally N. Adebamowo Research 03 February 2026 Article: 140 Social networking site use, depressive and anxiety symptoms in adolescents: evidence from a longitudinal cohort study (SCAMP) 社交网站使用与青少年抑郁和焦虑症状：来自纵向队列研究（SCAMP）的证据 Chen ShenBraulio M. Girela-SerranoMireille B. Toledano Research 03 February 2026 Article: 139 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel 使用经验证的三蛋白血清生物标志物组合进行早孕期自发性早产预测 Qiong LuoJuan WeiXuefeng B. Ling Research 02 February 2026 Article: 138 Household cannabis cessation and adolescent mental health outcomes in a prospective cohort study 一项前瞻性队列研究中家庭大麻戒断与青少年心理健康预后的关系 Ming WangYixiang XuFei Li Research 02 February 2026 Article: 137 Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies 所属专题合集：精神活性物质：娱乐性药物重新利用为新型疗法 Objective assessment of long-term impact of COVID-19 on multiple sensory functions 客观评估新冠肺炎对多种感觉功能的长期影响 Ahmad OdehVeronica L. FormanekKai Zhao Research 27 February 2026 Article: 136 Detection of hearing loss by formal audiological testing after acute infectious meningitis: a global systematic review and meta-analysis 急性感染性脑膜炎后通过正式听力检测诊断听力损失：一项全球系统综述和荟萃分析 Luisa F. AlvizCarla Y. KimKiran T. Thakur Review 28 February 2026 Article: 135 Part of 1 collection: Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述合集 Serological evidence of substantial respiratory syncytial virus infection burden among older adults residing in Swedish long-term care facilities 血清学证据表明，居住在瑞典长期护理机构中的老年人存在沉重的呼吸道合胞病毒感染负担 Preeti MoarChristoffer GranvikMattias N. E. Forsell Research 24 February 2026 Article: 134 Association of parental education with offspring psychiatric diagnoses, violent crimes, and suicidal behavior: a nationwide Swedish quasi-experimental study 父母受教育程度与后代精神疾病诊断、暴力犯罪和自杀行为之间的关联：一项瑞典全国范围的准实验研究 Mengping ZhouHenrik LarssonErik Pettersson Research 26 February 2026 Article: 133 Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis 外部验证的痴呆风险预测模型的鉴别性能：一项系统综述和荟萃分析 Blossom C. M. StephanJacob BrainMario Siervo Research 02 February 2026 Article: 132 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study 静脉注射大剂量硒预防铂敏感复发性卵巢癌化疗所致周围神经病变的有效性和安全性：一项3期、双盲、平行组、随机对照试点研究 Ga Won YimKyung Hee HanHee Seung Kim Research 02 February 2026 Article: 131 Time for change in implementation research and practice 实施研究和实践中变革的时机已到 Mike EnglishJacob McKnightSebastian Fuller Debate 02 February 2026 Article: 130 CardioMetAge estimates cardiometabolic aging and predicts disease outcomes CardioMetAge可评估心脏代谢年龄并预测疾病结局 Yucan LiXinming XuKelin Xu Research 31 January 2026 Article: 129 Disproportionate climate burden of rising temperatures on low birth weight in Pakistan 气温上升给巴基斯坦低出生体重儿带来的不成比例的气候负担 Syeda H. FatimaCorey J. A. BradshawZohra S. Lassi Research 31 January 2026 Article: 128 Part of 1 collection: Climate change and human health 所属专题：气候变化与人类健康 Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy 利用靶向CD3ε、EpCaM和4-1BB的三特异性T细胞衔接器增强溶瘤病毒疗法：临床前评估及对癌症免疫疗法的启示 Zhongyi DongHaoyu ZhangZizhen Zhang Research 30 January 2026 Article: 127 Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma 靶向降解BCL-XL与吉西他滨联用对胆管癌具有协同治疗作用 Qinghua ZengYan ZhangYonghan He Research 30 January 2026 Article: 126 Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4 DNA甲基化与高血压及血压的关联：来自KORA F4/FF4的7年纵向研究 Liye LaiAngelina Shin Yee JongMelanie Waldenberger Research 04 February 2026 Article: 125 Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis 精神活性物质使用与泛癌症的共享遗传结构：来自大规模全基因组跨性状分析的见解 Jiahang SongPengzhu LiOlivier Gires Research 05 February 2026 Article: 124 Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies 所属专题：精神活性物质：作为新型疗法的娱乐性药物再利用 Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children 宫内暴露于母体糖尿病与儿童患癫痫风险的关系：一项针对230万儿童的全国队列研究 Muhammad Zakir HossinMartina PerssonNeda Razaz Research 14 February 2026 Article: 123 ADHD and adherence to antihypertensive medication treatment: a multinational cohort study 多动症与坚持抗高血压药物治疗的关系：一项多国队列研究 Honghui YaoYiling ZhouZheng Chang Research 20 February 2026 Article: 122 How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project 重新加入长期减肥计划的效果如何？5年和10年磁共振成像评估的随访干预试验（FIT）项目 Hadar KleinDafna PachterIris Shai Research 30 January 2026 Article: 121 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减肥干预措施及其对健康的影响 Correction: Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings 更正：精神分裂症患者及其未受影响兄弟姐妹的脑状态动态与工作记忆 Feiwen WangJie YangLena Palaniyappan Correction 20 February 2026 Article: 120 Ocular light and optical radiation exposure as a modifiable environmental determinant of health: expert consensus on research gaps and priorities 作为可改变的环境健康决定因素的眼睛光暴露和光学辐射暴露：关于研究空白和优先事项的专家共识 Manuel SpitschanAnna M. BillerJohannes Zauner Guideline 29 January 2026 Article: 119 Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study 青少年饮食模式与神经心理功能：一项横断面和纵向研究 Alexios ManidisNicolas Ayala-AldanaJordi Julvez Research 29 January 2026 Article: 118 Part of 1 collection: Child and adolescent psychiatry 所属专题：儿童与青少年精神病学 Factors impacting the delivery of contextualized care in serious illness: a focus group study with healthcare professionals 影响危重症患者情境化护理实施的因素：一项针对医疗保健专业人员的焦点小组研究 Linda ModderkolkYvonne SchoonAnne B. Wichmann Research 29 January 2026 Article: 117 Part of 1 collection: Palliative care and medicine 所属专题：姑息治疗与医学 Early interventions for first onset of symptoms of mental health conditions: an umbrella review of systematic reviews 针对心理健康问题首次出现症状的早期干预措施：一项系统综述的伞式评价 Jasmine LeePhoebe BarnettSonia Johnson Research 29 January 2026 Article: 116 Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone 局灶性癫痫发作间期脑电图信号中嵌入的谐波模式：对致痫区的新见解 Lingli HuLingqi YeShuang Wang Research 28 January 2026 Article: 115 Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题合集：癫痫：发作预防、治疗和流行病学 Effects of aerobic or resistance exercise on sleep and cancer-related fatigue in patients with breast cancer during or after neoadjuvant chemotherapy: a 3-arm randomized controlled trial 有氧运动或抗阻运动对新辅助化疗期间或之后乳腺癌患者睡眠和癌症相关疲劳的影响：一项三臂随机对照试验 Alexander HaussmannMartina E. SchmidtKaren Steindorf Research 28 January 2026 Article: 114 Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis 中性粒细胞甲基丙二酸通过激活IL-6信号通路介导的中性粒细胞胞外诱捕网形成（NETosis），促进心肌梗死后微血栓形成和不良心脏重构 Yige LiuJiaxin WangShaohong Fang Research 28 January 2026 Article: 113 Statistical approaches to analyse the combined effect of seven air pollutants and breast cancer risk: a case–control study nested in the French E3N-Generations cohort 分析七种空气污染物联合作用与乳腺癌风险关系的统计方法：一项嵌套于法国E3N-Generations队列的病例对照研究 Camille GiampiccoloBéatrice FerversAmina Amadou Research 28 January 2026 Article: 112 Part of 1 collection: Carcinogens and human health 所属专题合集：致癌物与人类健康 Is behaviour change communication guidance for general practice healthcare professionals evidence based? A systematic review 针对全科医疗保健专业人员的行为改变沟通指导是否具有循证依据？一项系统综述 Anika Schwarze-ChintapatlaJonathan Livingstone-BanksCharlotte Albury Research 16 February 2026 Article: 111 Patient-centred postpartum care provision: virtual delivery, tiered escalation, and tensions between efficiency, preference, and clinical concern 以患者为中心的产后护理服务提供：虚拟服务模式、分级转诊机制，以及效率、患者偏好与临床关切之间的矛盾 Sergio A. SilverioJulia R. B. BrownEmma L. Duncan Research 24 February 2026 Article: 110 Ethical dilemmas in climate change and healthcare delivery: a cross-sectional survey of US patient perspectives 气候变化与医疗服务中的伦理困境：一项针对美国患者观点的横断面调查 Andrew HantelEmily SenayGregory A. Abel Research 27 January 2026 Article: 109 Part of 1 collection: Climate change and human health 所属专题：气候变化与人类健康 Inetetamab plus camrelizumab and utidelone for pretreated HER2-positive advanced breast cancer: a prospective, single-arm, phase 2 study 伊尼妥单抗联合卡瑞利珠单抗和优替德隆治疗既往接受过治疗的HER2阳性晚期乳腺癌：一项前瞻性、单臂、2期研究 Huimin LvTao SunMin Yan Research 27 January 2026 Article: 108 Potential of earlier primary care health checks for prevention of cardiovascular events in younger age groups: population-based study in the United Kingdom 早期初级保健健康检查对预防年轻人群心血管事件的潜力：英国一项基于人群的研究 Catherine A. ScottLinxin LiPeter M. Rothwell Research 24 January 2026 Article: 107 Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis 盐替代品对血压、心血管事件和死亡率影响的比较：一项系统综述和网络荟萃分析 Honghao LaiGihad NesrallahBradley C. Johnston Research 23 January 2026 Article: 106 Association of short-term exposure to ambient air pollutants with liver function and mediation by fasting insulin: evidence from a rural cohort in China 短期暴露于环境空气污染物与肝功能的关系及空腹胰岛素的中介作用：来自中国农村队列研究的证据 Mengxin WangAogang ZhangWeidong Wu Research 23 January 2026 Article: 105 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Adjuvant tislelizumab, lenvatinib, and capecitabine for resected biliary tract cancer: a prospective phase II trial 辅助治疗：替雷利珠单抗、仑伐替尼和卡培他滨用于可切除的胆道癌：一项前瞻性II期试验 Yun FengNing ZhangLu Wang Research 23 January 2026 Article: 104 Comparative effectiveness of sleeve gastrectomy and semaglutide for weight loss and metabolic outcomes: a prospective non-randomized study 袖状胃切除术与司美格鲁肽对减重及代谢结局的疗效比较：一项前瞻性非随机研究 Yutung YenQian ZhangYi Chen Research 22 January 2026 Article: 103 Part of 1 collection:Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响 Impact of sex on outcomes in patients treated with drug-coated balloons versus drug-eluting stents for de novo coronary artery lesions: Insights from the REC-CAGEFREE I trial 性别对接受药物涂层球囊与药物洗脱支架治疗的新发冠状动脉病变患者预后的影响：来自REC-CAGEFREE I试验的见解 Ping WangJingyu ZhouLing Tao Research 22 January 2026 Article: 102 Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models 通过多基因风险评分和时间事件模型评估哮喘与抑郁的共病情况 Xueting WangJun HeRenato Polimanti Research 22 January 2026 Article: 101 Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition 严重营养不良儿童出院后持续存在的免疫、凝血和心脏功能失调与后期死亡率相关 Brenda KamauEvans O. MudiboJames M. Njunge Research 22 January 2026 Article: 100 Correction: Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022 更正：计算机辅助口头尸检：对比大型语言模型与医生为2019 - 2022年塞拉利昂6939例死亡分配病因的情况 Richard WenAnteneh Tesfaye AssalifRashid Ansumana Correction 14 February 2026 Article: 99 Characteristics of parks associated with depression in women only: a cross-sectional study of 329,363 adults 仅与女性抑郁相关的公园特征：一项针对329,363名成年人的横断面研究 Jonathan R. OlsenNatalie NichollsRichard Mitchell Research 21 January 2026 Article: 98 Weight change mediates the effect of lifestyle intervention on postpartum diabetes in women with prior gestational diabetes: a secondary analysis of a randomized clinical trial 在生活方式干预对既往妊娠期糖尿病女性产后糖尿病影响中，体重变化的中介作用：一项随机临床试验的二次分析 Weiqin LiHuikun LiuGang Hu Research 21 January 2026 Article: 97 Part of 1 collection: Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与治疗 Global drivers of heart failure attributable to atrial fibrillation/flutter: insights fromJoinpoint regression, age-period-cohort analysis, and future projections from the GBD 2021 Study 心房颤动/扑动所致心力衰竭的全球驱动因素：来自折点回归、年龄-时期-队列分析以及2021年GBD（全球疾病负担）研究未来预测的见解 Jing ChenZhu LiGregory Y. H. Lip Research 20 January 2026 Article: 96 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Overdiagnosis of gestational diabetes mellitus during Ramadan: a retrospective population-based study in Catalonia, Spain 斋月期间妊娠期糖尿病的过度诊断：西班牙加泰罗尼亚地区一项基于人群的回顾性研究 Marta CarrascoBogdan VlachoMarta Hernández Research 20 January 2026 Article: 95 Part of 1 collection: Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与管理 Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England 为何当前基于风险因素的方法在预测死胎方面存在不足：英格兰初产妇全国队列研究 A. HowellB. ThilaganathanTommy’s National Centre for Maternity Improvement Research 22 January 2026 Article: 94 Pay-it-forward intervention increased pneumococcal vaccine uptake among older adults in China: a randomized controlled trial 爱心传递干预措施提高了中国老年人肺炎球菌疫苗的接种率：一项随机对照试验 Jiao QinChunxing TaoBingyu Liang Research 19 January 2026 Article: 93 The impact of e-cigarette taxation: a systematic review and meta-analysis on usage, pricing strategies, and public health implications 电子烟税收的影响：针对使用情况、定价策略和公共卫生影响开展的系统综述和荟萃分析 Quan WangZheng ZhuLi Yang Research 17 January 2026 Article: 92 Safety and preliminary efficacy results of IBI389, an anti-Claudin18.2×CD3 bispecific antibody, in patients with solid tumors and gastric or gastro-esophageal tumors: a phase 1 dose escalation and expansion study 抗Claudin18.2×CD3双特异性抗体IBI389在实体瘤及胃或胃食管肿瘤患者中的安全性与初步疗效结果：一项1期剂量递增与扩展研究 Xiaoyu LiRuihong DaiFeng Bi Research 16 January 2026 Article: 91 Part of 1 collection: Clinical trials for gastrointestinal cancer 所属专题：胃肠道癌症临床试验 Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study 比较非癌症疼痛使用阿片类药物者发生谵妄的风险：一项回顾性队列研究 Carlos Raul Ramirez MedinaMark LuntMeghna Jani Research 31 January 2026 Article: 90 Association between preoperative interruption of antiplatelet therapy and postoperative thrombotic risk after minimally invasive surgery for abdominopelvic cancer in patients treated with P2Y12 inhibitors 接受P2Y12抑制剂治疗的患者行腹部盆腔癌症微创手术时，术前中断抗血小板治疗与术后血栓形成风险之间的关联 Masashi KubotaSatomi YoshidaKoji Kawakami Research 16 January 2026 Article: 89 Comparative outcomes of distal ureterectomy vs. radical nephroureterectomy in high-risk distal ureteral urothelial carcinoma: a two-center cohort study in Northern and Southern China 高危远端输尿管尿路上皮癌患者行远端输尿管切除术与根治性肾输尿管切除术的疗效比较：中国北方和南方两家中心的队列研究 Junyi XieZhenhua LiuWei Yu Research 16 January 2026 Article: 88 Co-occurrence patterns and related risk factors of dementia and Parkinson’s disease among older adults across 204 countries and territories: a spatial correspondence and systematic analysis 204个国家和地区老年人痴呆症与帕金森病共现模式及相关危险因素：空间对应与系统分析 Weiyang ChenMin DuJue Liu Research 15 January 2026 Article: 87 Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study 肌萎缩侧索硬化症加速脑衰老及其预后关联：一项队列研究 Chenhao FangJiaoting JinShuoqiu Gan Research 15 January 2026 Article: 86 Part of 1 collection: Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题：肌萎缩侧索硬化症：最新进展与新动态 The clinical effects and cortical mechanism of rTMS in poststroke lateropulsion: a randomized controlled trial 重复经颅磁刺激（rTMS）对脑卒中后侧方倾倒的临床效果及皮质机制：一项随机对照试验 Lijiao MengRaymond C. C. TsangQuan Wei Research 14 January 2026 Article: 85 5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice 中脑背侧缝际核谷氨酸能神经元中的5-HT2C受体调控小鼠疼痛与焦虑共病 Qi ZhangLi XieRiyue Jiang Research 13 January 2026 Article: 84 The clinical landscape of POLE-mutant colorectal cancer: a retrospective analysis of real-world outcome POLE突变型结直肠癌的临床现状：一项现实结局的回顾性分析 Ting XuXuhui ZhangJian Li Research 13 January 2026 Article: 83 The efficacy and safety of duloxetine in treating refractory chronic cough: a randomized clinical trial 度洛西汀治疗难治性慢性咳嗽的有效性和安全性：一项随机临床试验 Shengyuan WangHeng WuXianghuai Xu Research 13 January 2026 Article: 82 Impact of diagnosis to ablation time on clinical outcomes in patients with atrial fibrillation: post hoc analysis of the CABANA trial 心房颤动患者从诊断到消融的时间对临床预后的影响：CABANA试验的事后分析 Manlin ZhaoYang ChenGregory Y. H. Lip Research 12 January 2026 Article: 81 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Elevated maternal pre-transfer serum lipid peroxidation is associated with implantation failure and early pregnancy loss 母体转运前血清脂质过氧化水平升高与着床失败和早期流产相关 Zhangwei JiaJunxiang RenJunhao Yan Research 12 January 2026 Article: 80 Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer 幽门螺杆菌感染对肠道和肿瘤内微生物组的影响及其与胃肠道癌症免疫治疗反应的关联 Keren JiaYang ChenLin Shen Research 12 January 2026 Article: 79 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物组：人类疾病的新疗法 SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis SGLT-2抑制剂在2型糖尿病合并代偿性肝硬化患者中的应用及其对肝脏相关预后和死亡率的影响 Tien-Shin ChouDaniel Hsiang-Te TsaiEdward Chia-Cheng Lai Research 12 January 2026 Article: 78 Extrapolating from trials to clinic: a predictive model defining the boundaries of benefit for multiple sclerosis therapies in real-world populations based on systematic review 从试验外推至临床：基于系统综述构建预测模型，界定多发性硬化症疗法在现实人群中的获益边界 Bibiana BielekovaTianxia WuMichael Calcagni Research 10 January 2026 Article: 77 A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data 利用最少患者数据早期预测坏死性软组织感染A组链球菌病因的验证模型 Sonja KatzJaco SuijkerEdoardo Saccenti Research 10 January 2026 Article: 76 Trends in lipid-lowering therapies in acute coronary syndromes after Chinese new insurance policy: a real-world analysis 中国新医保政策实施后急性冠状动脉综合征患者降脂治疗趋势：一项现实情况分析 Xin ZhaoShujing WuJunbo Ge Research 09 January 2026 Article: 75 Fragmented healthcare and effective maternal coverage in Mexico, 2009–2023 2009-2023年墨西哥医疗体系碎片化与有效孕产妇医疗保障 Edson Serván-MoriDiego Cerecero-GarcíaOctavio Gómez-Dantés Research 09 January 2026 Article: 74 Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models 昼夜节律紊乱与心血管疾病：基于动物模型机制证据的系统综述与荟萃分析 Mrinal K. DasEvi De RyckJohanna Samulin Erdem Research 09 January 2026 Article: 73 Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults 衰弱进展：多重共病组合模式在老年人衰弱状态转变及死亡风险预测中的作用 Rafael Ogaz-GonzálezQian ZouEva Corpeleijn Research 08 January 2026 Article: 72 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials 益生菌补充剂对健康人群肠道微生物群多样性的影响：一项针对随机对照试验的系统综述和荟萃分析 Anna Júlia ÉliásKincső Csepke Földvári-NagyLászló Földvári-Nagy Research 07 January 2026 Article: 71 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物群：人类疾病的新疗法 Pain and high-impact pain in community-dwelling older adults in Australia and relation to sociodemographic and health-related factors, including physical disability, psychological distress, and quality of life 澳大利亚社区居住老年人的疼痛及重度疼痛情况，及其与社会人口统计学因素和健康相关因素（包括身体残疾、心理困扰和生活质量）的关系 Grace JoshySaman Khalatbari-SoltaniEmily Banks Research 22 January 2026 Article: 70 Mortality and morbidity burden associated with smoking: evidence from a 1.6 million cohort in Hong Kong 与吸烟相关的死亡率和发病率负担：来自香港160万人队列研究的证据 Boyuan WangTingting ChenEric Yuk Fai Wan Research 06 January 2026 Article: 69 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Association between long-term extreme high temperature and mortality: a 9-million prospective cohort study 长期极端高温与死亡率之间的关系：一项900万人的前瞻性队列研究 Bo YinQi HuangKuiying Gu Research 06 January 2026 Article: 68 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach 利用网络毒理学和分子对接方法揭示氨甲环酸诱发癫痫的神经毒性机制 Tianyang ChenDalong LiuXiangYang Leng Research 03 January 2026 Article: 67 Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题：癫痫：癫痫发作的预防、治疗和流行病学 Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study Trop2免疫正电子发射断层扫描/计算机断层扫描（PET/CT）成像在前列腺癌中的应用：一项概念验证性转化研究 Xingru LongShuxian AnDawei Jiang Research 31 December 2025 Article: 66 Methylmalonate accumulation contributes to myocardial vulnerability post-reperfusion: a novel therapeutic target and prognostic biomarker 甲基丙二酸蓄积促进再灌注后心肌脆弱性：一种新型治疗靶点和预后生物标志物 Shanjie WangJunChen GuoShaohong Fang Research 31 December 2025 Article: 65 Prophylactic effect of intraoperative sodium oxybate on postoperative delirium in older patients undergoing major orthopedic surgery: a randomized clinical trial 术中羟丁酸钠对接受大型骨科手术的老年患者术后谵妄的预防作用：一项随机临床试验 Meiying CuiHang XuePing Zhao Research 31 December 2025 Article: 64 Part of 1 collection:Psychoactives: Recreational drugs repurposed as novel therapies 所属专题：精神活性物质：将娱乐性药物重新用于新型疗法 Prevalence of hysterectomy in urban China and associations between metabolic disorders and hysterectomy: a multicenter population-based study involving over 9 million women 中国城市子宫切除术的流行情况以及代谢紊乱与子宫切除术之间的关系：一项涉及超过900万女性的多中心人群基础研究 Yanrui BiYuan MaYing Gao Research 30 December 2025 Article: 63 Sex differences in cardiac risk and kidney function: serum creatinine versus cystatin C 心脏风险和肾功能方面的性别差异：血清肌酐与胱抑素C的对比 Nicole L. De La MataJames A. HedleyJennifer S. Lees Research 30 December 2025 Article: 62 The association of post-conization pregnancy with subsequent cervical lesions: evidence from a nationwide cohort in Sweden 锥切术后妊娠与后续宫颈病变的关联：来自瑞典全国队列研究的证据 Huan YiJimiao HuangJianguang Ji Research 29 December 2025 Article: 61 Tibial periosteal distraction for ischemic leg ulcers: animal and clinical cohort study 胫骨骨膜牵张术治疗缺血性下肢溃疡：动物及临床队列研究 Peilin ZhouWenqiang WangQikai Hua Research 28 December 2025 Article: 60 Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study 卡瑞利珠单抗联合紫杉醇和奈达铂对不可切除的晚期食管鳞癌的术前转化治疗：一项2期研究 Jinhong ZhuJinfeng ZhangJianqun Ma Research 28 December 2025 Article: 59 Clustering of cardiometabolic risk factors, physical activity, digital exclusion, and depressive symptoms trajectories in adults aged 50years and older: findings from two prospective cohort studies 50岁及以上成年人心血管代谢风险因素聚集、身体活动、数字排斥及抑郁症状轨迹：两项前瞻性队列研究的发现 Xiaosheng DongJiaqiang XiaoChengchao Zhou Research 28 December 2025 Article: 58 Eligibility of real-world patients for aspirin primary prevention trials in cardiovascular disease 现实中符合心血管疾病阿司匹林一级预防试验资格的患者情况 Michael HolderDaniel R. MoralesBruce Guthrie Research 27 January 2026 Article: 57 Polygenic risk score-guided personalized osteoporosis screening: a population-based study 基于多基因风险评分指导的个性化骨质疏松症筛查：一项基于人群的研究 Dongxue WangWen SunJianguang Ji Research 14 January 2026 Article: 56 Urea cycle modulation by combined SGLT2 inhibitors and metformin SGLT2抑制剂与二甲双胍联合用药对尿素循环的调节作用 Makoto HaradaJonathan AdamRui Wang-Sattler Research 08 January 2026 Article: 55 Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study VCP抑制剂ML240在大型动物及人视网膜外植体中的安全性和神经保护功效：一项临床前离体研究 Ana-Cristina Almansa-GarcíaAngela ArmentoBlanca Arango-Gonzalez Research 10 January 2026 Article: 54 Impact of an eight-week isocaloric vegan dietary intervention on hemogram parameters and lymphocyte subsets: a randomized-controlled trial 为期八周的等热量纯素饮食干预对血细胞参数和淋巴细胞亚群的影响：一项随机对照试验 Julian HerterFrieda StübingMaximilian Andreas Storz Research 10 January 2026 Article: 53 Association between psychosocial factors and adverse effects of light-to-moderate ambient heat in patients with chronic diseases: results of the prospective cohort study CLIMATE-II 社会心理因素与轻至中度环境热对慢性病患者不良影响之间的关联：前瞻性队列研究CLIMATE-II的结果 Ingmar SchäferValentina PauckeDagmar Lühmann Research 15 January 2026 Article: 52 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Maternal infection during pregnancy and the risk of childhood cancer: a systematic review and meta-analysis 孕期母体感染与儿童期患癌风险：一项系统综述和荟萃分析 Loviisa MulanjeLara Kim BrackmannRajini Nagrani Research 14 January 2026 Article: 51 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Supplementary biomarker testing in molecular tumor boards increases actionable therapy recommendations: a prospective real-world study of 658 patients 分子肿瘤委员会中的补充生物标志物检测增加了可采取治疗措施的建议：一项针对658例患者的前瞻性真实世界研究 Alexander ScheiterSimon MellinKirsten Utpatel Research 14 January 2026 Article: 50 Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022 计算机辅助口头尸检：对比大型语言模型与医生对塞拉利昂2019 - 2022年6939例死亡原因的判定 Richard WenAnteneh Tesfaye AssalifRashid Ansumana Research 24 December 2025 Article: 49 Loss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank Y染色体缺失及其在男性肌萎缩侧索硬化症中的影响：来自英国生物银行的研究见解 Wei-Ming SuQing-Qing DuanYong-Ping Chen Research 24 December 2025 Article: 48 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题：肌萎缩侧索硬化症：最新进展与新动态 Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner 产前脂多糖暴露通过调节间充质成纤维细胞以时间和剂量依赖性方式来影响早期肺部发育 Ying DongStefan HadzicSaverio Bellusci Research 22 December 2025 Article: 47 Life course socioeconomic trajectories and chronic disease risk in later life among 30,055 older adults across 27 European countries (the SHARE study) 27个欧洲国家30,055名老年人生命历程中的社会经济轨迹与晚年慢性疾病风险（基于SHARE研究） Taymara C. AbreuJoline W. J. BeulensJoreintje D. Mackenbach Research 20 December 2025 Article: 46 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学与风险因素的作用 Validation of a novel patient-reported measure of the burden of digital care in diabetes 由糖尿病患者报告的数字化护理负担新型测评工具的验证 Misk Al ZahidyJennifer L. RidgewayVictor M. Montori Research 20 December 2025 Article: 45 Determinants of long-term SARS-CoV-2 immune responses in asymptomatic-to-moderate COVID-19 patients in sub-Saharan Africa 撒哈拉以南非洲地区无症状至中度 COVID-19 患者长期 SARS-CoV-2 免疫应答的决定因素 Víctor L. de RiojaOdin GoovaertsGemma Moncunill Research 14 January 2026 Article: 44 Camrelizumab and apatinib in Chinese patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid cancer: an exploratory open-label, single-arm trial 卡瑞利珠单抗联合阿帕替尼治疗中国局灶性晚期或转移性放射性碘难治性分化型甲状腺癌：一项探索性开放标签单臂试验 Xin ZhangDi SunYansong Lin Research 18 December 2025 Article: 43 Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial 地中海饮食的尿液多酚特征与心血管疾病风险较低相关：PREDIMED 试验 Inés Domínguez-LópezPolina GalkinaRosa M. Lamuela-Raventós Research 18 December 2025 Article: 42 Meta-analysis and external validation of a risk model for gastrointestinal bleeding after percutaneous coronary intervention 经皮冠状动脉介入治疗后胃肠道出血风险模型的荟萃分析及外部验证 Hualong MaCong PengQiaohong Yang Research 18 December 2025 Article: 41 DNA methylation-based clocks, tobacco smoking, and lung cancer risk 基于DNA甲基化的生物钟、烟草吸烟与肺癌风险 Ricardo Cortez Cardoso PenhaJustina Ucheojor OnwukaMattias Johansson Research 17 December 2025 Article: 40 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70years old 认知功能未受损的70岁老年人基于人口的队列中，与大脑灰质模式相关的风险和保护因素 Giulia LorenzonAnna MarsegliaEric Westman Research 17 December 2025 Article: 39 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学和风险因素的作用 Street view-derived city built environment and vulnerability to temperature extremes: a nationally representative population-based cohort study 基于街景图像的城市建成环境与极端温度脆弱性：一项全国代表性人口队列研究 Wanzhou WangChao YangLuxia Zhang Research 16 December 2025 Article: 38 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity 针对病毒变异株的灭活严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）疫苗加强针可维持保护性体液免疫和细胞免疫 Constanza MéndezLinmar Rodríguez-GuilarteSusan M. Bueno Research 15 December 2025 Article: 37 Dapagliflozin alleviates sunitinib-induced cardiotoxicity through AMPKα-PPARα axis and enhances the sensitivity of renal cell carcinoma to sunitinib 达格列净通过AMPKα-PPARα轴减轻舒尼替尼诱导的心脏毒性，并增强肾细胞癌对舒尼替尼的敏感性 Shi-yu HuangMin HuLei Wang Research 15 December 2025 Article: 36 Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study 新诊断癫痫患者言语流畅性缺陷背后的网络功能障碍：一项静息态功能磁共振成像功能连接研究 Fangzhou LiuPing JiangLing Liu Research 13 December 2025 Article: 35 Part of 1 collection:Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题：癫痫：癫痫发作的预防、治疗和流行病学 Long-term quality of life in non-epithelial ovarian cancer survivors: TMRG-GINECO-Vivrovaire rare tumors case–control study 基于广西新生儿地中海贫血基因组图谱计划开展的家庭三联体/四联体分析 Coraline DubotIsabelle Ray-CoquardFlorence Joly Research 12 December 2025 Article: 34 Family trios/quartets analysis based on the Newborn Genomic Atlas for Thalassemia project in Guangxi 非上皮性卵巢癌幸存者的长期生活质量：TMRG-GINECO-Vivrovaire罕见肿瘤病例对照研究 Wei WeiChunrong GuiBaoheng Gui Research 12 December 2025 Article: 33 Hyperuricemic persons use more analgesics than normouricemic—is asymptomatic hyperuricemia really asymptomatic? 高尿酸血症患者比血尿酸正常者使用更多镇痛药——无症状性高尿酸血症真的“无症状”吗？ Janis TimsansJenni Emilia KauppiMarkku Kauppi Research 11 December 2025 Article: 32 Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses 社会孤立、孤独感与多系统医学病症：全表型组关联分析及疾病轨迹研究 Tingshan DuanZhi CaoChenjie Xu Research 10 December 2025 Article: 31 Digital marketing techniques within online food retail platforms: a scoping review 在线食品零售平台中的数字营销技巧：一项范围综述 Adyya GuptaCatherine E. HugginsAnna Peeters Research 10 December 2025 Article: 30 Dramatic increases in redundant publications in the Generative AI era 生成式人工智能时代冗余出版物数量急剧增加 Danny MaupinTulsi SuchakMatt Spick Research 09 December 2025 Article: 29 Cardiovascular risk burden and guideline-recommended lipid and blood pressure goals in an Italian Cohort: findings from the HUMTELEMED web-based platform 意大利人群心血管风险负担及指南推荐的血脂和血压目标达成情况：HUMTELEMED网络平台的发现 Matteo LandolfoAlessandro GezziRiccardo Sarzani Research 09 December 2025 Article: 28 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial Janus激酶1/2抑制剂KL130008治疗活动性类风湿关节炎的有效性和安全性：一项随机、双盲、安慰剂对照的II期试验 Yue ChengHonghu TangYi Liu Research 09 December 2025 Article: 27 Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants 子宫内膜癌的风险分层：英国生物银行129,829名参与者中多基因风险评分和体重指数的独立及联合效应 Xuemin WangLaure DossusTracy A. O’Mara Research 10 February 2026 Article: 26 Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice 孕期摄入益生菌及纯母乳喂养初乳与新生儿黄疸风险降低相关 Bekalu Kassie AlemuChi Chiu WangYao Wang Research 08 December 2025 Article: 25 Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures 绝经后女性脂肪肝具有独特的血清细胞外囊泡蛋白质组特征 Patrick PirrotteBrooke LovellJohanna K. DiStefano Research 07 December 2025 Article: 24 Global, regional, and national temporal trends in the prevalence of environmental heat and cold exposure among older adults aged 60–99 years, 1990–2021: an age-period-cohort analysis based on the Global Burden of Disease Study 2021 基于2021年全球疾病负担研究，对1990 - 2021年60 - 99岁老年人环境热暴露和冷暴露患病率的全球、区域和国家时间趋势分析：一项基于年龄 - 时期 - 队列模型的分析 Shenghao XuJing WangJianlin Xiao Research 07 December 2025 Article: 23 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models 亲环蛋白B缺乏可增强心肌能量合成，并在临床前模型中预防心力衰竭 Xiao ZongXierenayi TudiRong Tao Research 07 December 2025 Article: 22 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Normobaric hyperoxia for intracerebral hemorrhage: a randomized clinical trial 常压高氧治疗脑出血：一项随机临床试验 Zhiying ChenJiayue DingRan Meng Research 07 December 2025 Article: 21 Nationwide trends in pediatric hospitalizations for eating disorders in France between 2013 and 2022: a retrospective study using the national health insurance database Emmanuelle LogeaisFrançoise TroussierLilia Khendek 2013 - 2022年法国因进食障碍住院的儿科患者全国趋势：一项使用国家健康保险数据库的回顾性研究 Research 05 December 2025 Article: 20 Part of 1 collection:Child and adolescent psychiatry 所属专题：儿童与青少年精神病学 Self-management of vaginal pessaries for pelvic organ prolapse: multi-method process evaluation, linked to the TOPSY randomised controlled trial 盆腔器官脱垂阴道子宫托自我管理：与TOPSY随机对照试验相关的多方法过程评估 Carol BuggeMelanie Dembinskythe TOPSY team Research 05 December 2025 Article: 19 Large-scale plasma proteomics reveals bidirectional associations between sleep patterns and inflammatory bowel disease: a prospective cohort study 大规模血浆蛋白质组学研究揭示睡眠模式与炎症性肠病之间的双向关联：一项前瞻性队列研究 Kaixing LeYaru LiuZhigang Liu Research 05 December 2025 Article: 18 Association between socioeconomic status and diabetic retinopathy in individuals with type 1 diabetes: a systematic review and meta-analysis 1型糖尿病患者社会经济地位与糖尿病视网膜病变之间的关联：一项系统综述和荟萃分析 Fernando Sebastian-VallesSergio Núñez de Arenas-ArroyoJulia Martínez-Alfonso Review 05 December 2025 Article: 17 Patterns of disparity: age and socioeconomic differences in women’s smoking and quitting outcomes in Great Britain 差异模式：英国女性吸烟及戒烟结局的年龄和社会经济差异 Sarah E. JacksonCaitlin NotleySharon Cox Research 10 February 2026 Article: 16 Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression SWI/SNF复合体中的基因组致病性改变通过下调STING表达损害中国KRAS突变型非小细胞肺癌患者的免疫治疗效果 Lingling GaoJie JiangXuchao Zhang Research 03 December 2025 Article: 15 Residential radon exposure and incident myocardial infarction and stroke risks in the All of Us Research Program “我们所有人”研究项目中住宅氡暴露与心肌梗死和卒中发病风险的关系 Jiajun LuoZhihao JinBriseis Aschebrook-Kilfoy Research 03 December 2025 Article: 14 Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias 用于延缓神经退行性变的地中海饮食-终止高血压膳食疗法干预措施（MIND）与心血管疾病及心律失常的关系 Pei QinFrederick K. HoJill P. Pell Research02 December 2025 Article: 13 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population KoMethylNet：基于神经网络分析DNA甲基化数据的新型表观遗传时钟及韩国人群的表观遗传年龄加速研究 Dabin YunKwangyeon OhNan Song Research 03 December 2025 Article: 12 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants 睡眠与体力活动的权衡与痴呆风险：英国生物样本库参与者的一项前瞻性队列研究 Stephanie YiallourouLachlan CribbMatthew P. Pase Research 03 December 2025 Article: 11 Part of 1 collection: Sleep and mental health 所属专题：睡眠与心理健康 Integration of gut microbiome and lipid metabolism reveals the anti-cancer effects of pentadecanoic acid on bladder cancer 肠道微生物组与脂质代谢的整合揭示十五烷酸对膀胱癌的抗癌作用 Ya-Ting ChenJing SuiEvan Yi-Wen Yu Research 03 December 2025 Article: 10 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物群：人类疾病的新疗法 A social determinants-based county-level cardiovascular mortality index to identify high-risk counties in the USA 基于社会决定因素的美国县级心血管疾病死亡率指数，用于识别高风险县 Anqi ZhuBibhas ChakrabortyTazeen H. Jafar Research 02 December 2025 Article: 9 HIV infection and immunosenescence: challenges and intervention strategies HIV感染与免疫衰老：挑战与干预策略 Junyan JinQianqian XuBin Su Review 02 December 2025 Article: 8 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学与风险因素的作用 Machine learning-based prediction of short-term outcomes in aneurysmal subarachnoid hemorrhage: a multicenter study integrating clinical and inflammatory indicators 基于机器学习的动脉瘤性蛛网膜下腔出血短期预后预测：一项整合临床与炎症指标的多中心研究 Weichong ZhouCong PengHui Shi Research 29 November 2025 Article: 7 The effectiveness and safety of a mobile application-based self-regulation intervention to support weight loss among adults living with obesity: a large-scale pragmatic randomised controlled trial 基于移动应用程序的自我调节干预措施在支持肥胖成年人减重方面的有效性与安全性：一项大规模实用性随机对照试验 Paul DoodyGina M. WrenPaul Aveyard Research 29 November 2025 Article: 6 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响 Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults 脂肪堆积（肥胖程度）与首次确诊精神疾病的关系：一项基于1000万英国成年人的队列研究 Xue DongPaul AveyardMin Gao Research 29 November 2025 Article: 5 Efficacy of standard care versus acoustic therapy on acute tinnitus in idiopathic sudden sensorineural hearing loss: a randomized controlled trial 标准治疗与声治疗对特发性突发性感音神经性听力损失伴急性耳鸣的疗效对比：一项随机对照试验 Xinyi WangKe QiuYu Zhao Research 28 November 2025 Article: 4 Trends and socio-economic inequalities in overweight- and obesity-related premature cardiovascular disease mortality in Australia 澳大利亚超重与肥胖相关过早心血管疾病死亡的趋势及社会经济不平等状况 Tim Adair Research 29 January 2026 Article: 3 Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study 评估孕期母体血压对围产期健康的影响：一项广角孟德尔随机化研究 Fernanda Morales-BersteinAna Gonçalves-SoaresMaria-Carolina Borges Research 14 January 2026 Article: 2 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与管理 Prevalence of use and interest in using glucagon-like peptide-1 receptor agonists for weight loss: a population study in Great Britain 胰高血糖素样肽-1受体激动剂用于减重的使用率及使用意愿：一项针对英国人群的研究 Sarah E. JacksonJamie BrownLion Shahab Research 08 January 2026 Article: 1 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响

2026-04-23

·蓉药

不止有ADC！一文读懂四川创新药“天团”的15款核心武器

当全球医药创新的目光聚焦于长三角、珠三角时，在中国西部，一片创新的“热土”正在悄然改变中国生物医药的版图。四川，凭借其深厚的科研底蕴、人才储备和活跃的资本，已崛起为不容忽视的创新药策源地。这里不仅有科伦博泰的ADC药物成功出海，创下国产创新药授权纪录；更有百利天恒凭借全球首创的双抗ADC，在国际舞台崭露头角。从成都先导的万亿级分子库，到至善唯新“一针治愈”血友病的基因疗法；从康弘药业让中国眼药走向世界，到威斯津生物在mRNA疫苗领域的全球竞速……15家川内创新药企，正以ADC、基因治疗、细胞治疗、多肽药物、RNA药物、治疗性疫苗等前沿技术为矛，向肿瘤、代谢性疾病、感染性疾病等重大未满足临床需求发起冲锋。本文旨在为您系统梳理这15家四川创新药代表企业的核心产品管线。我们将穿越实验室与临床试验，揭秘这些“硬核”药物背后的科学逻辑、研发进展与市场潜力，一窥“四川智造”如何在中国乃至全球的创新药浪潮中，扮演越来越关键的角色。公司名称核心产品详细介绍作用方向功效/适应症 1 百利天恒 BL-B01D1 (iza-bren) 全球首创EGFR×HER3双抗ADC药物，由EGFR×HER3双特异性抗体、可裂解连接子和新型拓扑异构酶I抑制剂Ed-04有效载荷组成。靶向治疗多种实体瘤用于复发性或转移性食管鳞癌、非小细胞肺癌、小细胞肺癌、鼻咽癌、卵巢癌等。在鼻咽癌III期临床中，客观缓解率(ORR)达54.6%，中位无进展生存期(mPFS)8.38个月。 2 科伦博泰芦康沙妥珠单抗 (sac-TMT/SKB264) 靶向TROP2的ADC药物，由人源化抗TROP2单抗、可酶促裂解连接子和新型拓扑异构酶I抑制剂组成。靶向治疗TROP2阳性实体瘤已获批用于：1)经EGFR-TKI和含铂化疗治疗后进展的EGFR突变阳性非鳞状NSCLC；2)既往至少接受过2种系统治疗的不可切除局部晚期或转移性三阴性乳腺癌(TNBC)；3)经EGFR-TKI治疗后进展的EGFR突变阳性非鳞状NSCLC。新增HR+/HER2-乳腺癌适应症已获受理。 2 科伦博泰博度曲妥珠单抗 (A166) 差异化的HER2 ADC药物。靶向治疗HER2阳性实体瘤用于既往接受过抗HER2药物治疗的不可切除或转移性HER2阳性乳腺癌。 3 康弘药业康柏西普眼用注射液 (朗沐) 抗血管内皮生长因子(VEGF)融合蛋白，是中国首个获WHO国际通用名的生物I类新药。抑制眼底新生血管生成用于治疗：1)新生血管性(湿性)年龄相关性黄斑变性(nAMD)；2)继发于病理性近视的脉络膜新生血管(pmCNV)引起的视力损伤；3)继发于糖尿病黄斑水肿(DME)引起的视力损伤；4)继发于视网膜静脉阻塞(RVO)的黄斑水肿引起的视力损伤。 4 成都先导 DNA编码化合物库(DEL)筛选服务拥有国际领先的DNA编码化合物库技术平台，化合物库总量超40亿（含38亿小分子和2亿环肽/线性肽）。新药早期发现与优化为全球药企和科研机构提供高效的苗头化合物发现和先导化合物优化服务，加速创新药研发进程。其OpenDEL®平台提供自助筛选服务。 5 圣诺生物多肽原料药与制剂拥有21个自主研发的多肽原料药品种，包括司美格鲁肽、替尔泊肽、利拉鲁肽、依替巴肽、生长抑素、胸腺法新等。多肽类药物生产与销售司美格鲁肽/替尔泊肽/利拉鲁肽：用于2型糖尿病、肥胖症管理。依替巴肽：用于急性冠状动脉综合征，降低死亡或新发心肌梗死风险。生长抑素：用于严重急性消化道出血、胰胆肠瘘辅助治疗等。胸腺法新：用于慢性乙型肝炎、增强免疫损害者疫苗应答。维培那肽：GLP-1受体激动剂，用于2型糖尿病和肥胖症。 6 海创药业氘恩扎鲁胺软胶囊 (海纳安®/HC-1119) 第二代雄激素受体(AR)抑制剂，具有更优化的药代动力学特征。治疗前列腺癌用于治疗接受醋酸阿比特龙及化疗后出现疾病进展，且既往未接受新型AR抑制剂的转移性去势抵抗性前列腺癌(mCRPC)成人患者。可显著延长患者无进展生存期(PFS)，降低疾病进展或死亡风险42%。 6 海创药业 HP518 中国首款进入临床阶段的口服AR PROTAC在研药物，能降解野生型及突变型AR蛋白。靶向蛋白降解治疗前列腺癌用于治疗转移性去势抵抗性前列腺癌(mCRPC)。临床I期显示安全性良好，并观察到抗肿瘤活性。 7 微芯药业(成都) 西达本胺 (爱谱沙®) 全球首个亚型选择性组蛋白去乙酰化酶(HDAC)抑制剂，属于表观遗传调控剂。表观遗传调控抗肿瘤在中国已获批：1)复发或难治性外周T细胞淋巴瘤(PTCL)；2)联合芳香化酶抑制剂治疗HR+/HER2-绝经后晚期乳腺癌；3)弥漫大B细胞淋巴瘤(DLBCL)。在日本获批用于成人T细胞白血病(ATL)和PTCL。 7 微芯药业(成都) 西格列他钠 (双洛平®) 全球首个获批上市的PPAR全激动剂。胰岛素增敏治疗2型糖尿病用于治疗2型糖尿病患者，可单药或与二甲双胍联用。已纳入国家医保目录。 7 微芯药业(成都) 西奥罗尼三通路肿瘤靶向抑制剂，机制新颖。多靶点抗肿瘤正在开展联合疗法治疗胰腺导管腺癌、铂耐药复发卵巢癌等适应症的II/III期临床试验。 8 海博为药业 HBW-3220胶囊三代/四代抗耐药、可逆BTK抑制剂，能克服C481突变产生的耐药性。抑制BTK治疗B细胞淋巴瘤及自身免疫病主要适应症：1)复发/难治性B细胞非霍奇金淋巴瘤、慢性淋巴细胞白血病/小淋巴细胞淋巴瘤(CLL/SLL)；2)肾小球肾炎（如膜性肾病、狼疮肾炎）。临床前及早期临床显示其较已上市BTK抑制剂有差异化优势。 9 赜灵生物甲磺酸普依司他 (PM) 新型HDAC I/IIb高选择性抑制剂，是目前唯一同时获批用于B细胞、T细胞淋巴瘤及实体瘤治疗的HDAC抑制剂。表观遗传调控抗肿瘤适应症：1)复发或难治性弥漫大B细胞淋巴瘤(R/R DLBCL)；2)多发性骨髓瘤；3)晚期实体瘤（联合治疗）。已启动治疗R/R DLBCL的关键III期临床。 10 至善唯新 ZS801注射液 rAAV基因治疗药物，采用适合中国人群的AAV血清型载体。基因治疗B型血友病用于治疗B型血友病（凝血因子IX缺乏）。早期临床显示，首例受试者接受低剂量治疗7周后，凝血活力从严重型(<1%)升至轻型(5-40%)。旨在实现"一针治愈"。 10 至善唯新 ZS802 rAAV基因治疗药物，采用全球最小的肝脏特异启动子和优化后的凝血VIII因子序列。基因治疗A型血友病用于治疗A型血友病（凝血因子VIII缺乏）。已获批开展临床研究。 10 至善唯新 ZS805注射液 rAAV基因治疗药物，搭载自主研发的肝脏特异启动子和优化后的α-Gal A基因。基因治疗法布雷病用于治疗法布雷病（α-半乳糖苷酶A缺乏症）。中国首个法布雷病基因新药，已启动I/II期临床试验。仅需一次治疗，有望长期有效。 11 迈科康生物重组带状疱疹疫苗(CHO细胞) 采用CHO细胞表达的重组VZV糖蛋白E和自创的MA105佐剂系统。预防带状疱疹用于40岁以上人群预防水痘-带状疱疹病毒引发的带状疱疹。临床III期已完成，保护效力达预设标准，安全性优异。已提交上市申请。 11 迈科康生物重组呼吸道合胞病毒(RSV)疫苗(CHO细胞) 采用重组蛋白技术路线和自研MA103佐剂系统。预防RSV感染用于预防由呼吸道合胞病毒引起的下呼吸道疾病。已进入临床III期阶段。 12 凯米生物 SN2001 (IPT-HBV) 基于SynNeogen®平台的嵌合多抗原治疗性疫苗，通过Fc靶向树突状细胞，诱导强效抗病毒T细胞反应。治疗慢性乙型肝炎旨在实现慢性乙肝的功能性治愈（HBsAg转阴）。已在澳大利亚启动I期临床，安全性耐受性良好。 12 凯米生物 KMV002/SN3001 (IPT-PAP) 基于SynNeogen®平台的免疫启动疗法(IPT)。治疗前列腺癌用于治疗转移性去势抵抗性前列腺癌(mCRPC)。计划申报美国FDA IND，力争成为全国首款进入临床的通用型前列腺癌治疗性疫苗。 13 奥达生物 AOD113408注射液 GLP-1R/GCG双受体激动剂，基于公司长效化修饰技术，通过突变肽链关键位点延长半衰期。治疗代谢性疾病适应症：非酒精性脂肪性肝炎(NASH)。正在健康受试者和超重/肥胖受试者中开展I期临床试验。该技术平台还布局了长效GLP-1、GLP-1/GIP双靶点激动剂等。 14 威斯津生物 WGc-0201 全球首个针对乙型肝炎病毒(HBV)的mRNA治疗性疫苗，基于自主mRNA序列设计和LNP递送平台。 mRNA疫苗治疗HBV相关肝癌用于治疗乙型肝炎病毒(HBV)相关肝癌。可诱导抗病毒与抗肿瘤双重免疫应答。已获美国FDA和中国NMPA临床试验许可。 14 威斯津生物 WGc-043 全球首款针对EB病毒(EBV)相关肿瘤的mRNA治疗性疫苗。 mRNA疫苗治疗EBV阳性肿瘤用于治疗EBV阳性肿瘤，如鼻咽癌和自然杀伤T细胞淋巴瘤。已完成研究者发起的临床试验(IIT)，展现出优越的安全性和有效性。 15 四川泸州步长生物 BC008-1A注射液重组抗PD-1/TIGIT人源化双特异性抗体，全球首个进入临床阶段的PD-1/TIGIT双靶点药物。双免疫检查点抑制治疗实体瘤用于晚期实体瘤，包括胶质母细胞瘤、非小细胞肺癌、食管癌等。通过同时阻断PD-1和TIGIT信号通路，解除T细胞抑制，增强抗肿瘤作用。 15 四川泸州步长生物注射用重组抗VEGFR2全人单克隆抗体抗血管内皮生长因子受体2(VEGFR2)全人单克隆抗体。抗血管生成治疗实体瘤用于晚期实体瘤。已进入III期临床试验阶段。

2026-04-22

·ioncology

瞭望前瞻丨ASCO摘要标题公布！17项中国恶性黑色素瘤及皮肤癌研究入选，一文速览

点击上方蓝字关注我们编者按：2026年美国临床肿瘤学会年会（ASCO）将于当地时间5月29日至6月2日在美国芝加哥举行。日前，ASCO年会入选摘要标题已发布。在恶性黑色素瘤及皮肤癌领域，共有17项中国研究入选，包括2项口头报告和15项壁报，覆盖了机制探索、免疫治疗、细胞疗法、手术治疗等多个领域，为全球相关诊疗带来了新的启发。《肿瘤瞭望》特别整理中国研究进展如下，如有疏漏，欢迎留言指正。 01 快速口头报告（Rapid Oral Abstract Session）黑色素瘤/皮肤癌专场 Melanoma/Skin Cacners 美国中部夏令时间：5月30日 04:30-06:00 PM 北京时间：5月31日 05:30-07:00 AM 专场地点：E451 摘要号：9516 Cadonilimab or ivonescimab plus axitinib in metastatic mucosal melanoma: Results from a phase Ib trial. 卡多尼单抗或依沃西单抗联合阿昔替尼治疗转移性黏膜黑色素瘤：Ib期临床试验结果讲者：毛丽丽教授，北京大学肿瘤医院报告时间：05:06-05:12 PM CDT 02 临床科学研讨会（Clinical Science Symposium）黑色素瘤过继细胞疗法加速之路：我们对此是否认同？ Accelerating Adoptive Cell Therapy in Melanoma: Are We Sold on Cells? 美国中部夏令时间：6月1日 04:30-06:00 PM 北京时间：6月2日 05:30-07:00 AM 专场地点：E451 摘要号：LBA9509 A multicenter, randomized, controlled, open-label, phase II trial of autologous tumor-infiltrating lymphocytes (GC101 TIL) in patients with advanced melanoma. 针对晚期黑色素瘤患者应用自体肿瘤浸润淋巴细胞（GC101 TIL）治疗的一项多中心、随机、对照、开放标签的 II 期临床试验讲者：斯璐教授，北京大学肿瘤医院报告时间：04:54-05:06 PM CDT 03 壁报（Poster Session）治疗进展-免疫专场 Developmental Therapeutics – Immunotherapy 美国中部夏令时间：5月30日 01:30PM 北京时间：5月31日 02:30 AM 专场地点：Hall A 摘要号：2527 Safety and efficacy of a novel PD-L1/4-1BB bispecific antibody QLF31907 in previously-treated patients with advanced melanoma: Results from a phase 2 study. 新型PD-L1/4-1BB双特异性抗体QLF31907治疗经治晚期黑色素瘤患者的安全性及疗效：一项II期研究结果讲者：郭军教授，北京大学肿瘤医院黑色素瘤/皮肤癌专场 Melanoma/Skin Cacners 美国中部夏令时间：5月31日 09:00AM 北京时间：5月31日 10:00 PM 专场地点：Hall A 摘要号：9537 Prognostic and therapeutic implications of HRR gene mutations in non-cutaneous melanoma: Association with anti-PD-1 efficacy. HRR 基因突变在非皮肤型黑色素瘤中的预后及治疗意义：与抗 PD-1 疗效的相关性分析讲者：连斌教授，北京大学肿瘤医院摘要号：9554 Stage I results of a phase II study evaluating thymosin α1 combined with toripalimab in elderly patients with advanced melanoma. 评估胸腺肽α1联合特瑞普利单抗治疗老年晚期黑色素瘤的Ⅱ期研究的第Ⅰ阶段结果讲者：文习之教授，中山大学肿瘤防治中心摘要号：9562 The efficacy and safety of neoadjuvant toripalimab combined with temozolomide in resectable stage III melanoma: A prospective, single-center, phase 2 trial. 特瑞普利单抗联合替莫唑胺新辅助治疗可切除 III 期黑色素瘤的疗效与安全性：一项前瞻性、单中心、Ⅱ期临床试验讲者：胡涂教授，复旦大学附属肿瘤医院摘要号：9571 Neoadjuvant camrelizumab plus apatinib and temozolomide for resectable stage III acral melanoma: Updated CAP 03-NEO trial results and external control comparison. CAP 03-NEO 试验最新结果与拓展对照比较：卡瑞利珠单抗联合阿帕替尼及替莫唑胺新辅助治疗可切除 III 期肢端黑色素瘤讲者：魏晓婷教授，北京大学肿瘤医院 04 仅发表摘要（Publication Only）摘要号：e14023 Synergistic efficacy of intrathecal PD-1 blockade combined with whole-brain radiotherapy for melanoma leptomeningeal metastases: A real-world analysis. 鞘内PD-1阻断联合全脑放疗治疗黑色素瘤软脑膜转移的协同疗效：一项真实世界分析讲者：甄俊杰教授，广东三九脑科医院摘要号：e14504 Preclinical study on the efficacy of CD4/TGF-β bispecific antibody (MR001) and temozolomide combination therapy for the treatment of multiple metastatic melanoma based on MagIC-PDX model. 基于MagIC-PDX模型评估CD4/TGF-β双特异性抗体（MR001）联合替莫唑胺治疗多发性转移性黑色素瘤疗效的临床前研究讲者：Shiying Lu，南方医科大学国际教育学院摘要号：e14591 The role and mechanism of tertiary lymphoid structure and its associated B cells in the resistance of immune checkpoint inhibitor therapy in acral melanoma. 三级淋巴结构与B细胞在肢端黑色素瘤免疫检查点抑制剂治疗抵抗中的作用与机制研究讲者：杨吉龙教授，天津医科大学肿瘤医院摘要号：e18150 A novel endoscopic sleeve en bloc resection for sinonasal mucosal melanoma: A propensity score–matched comparison with conventional endoscopic surgery. 一种用于鼻窦黏膜黑色素瘤的新型内镜下套袖状切除术：一项与传统内镜手术的倾向性评分匹配对比研究讲者：薛凯教授，复旦大学附属眼耳鼻喉科医院摘要号：e21506 NICE-TIL (NKG2D-CAR/mbIL15/tEGFR-transduced TILs) and antitumor activity via dual TCR-HLA and NKG2D-NKG2DL killing pathways. NICE-TIL（NKG2D-CAR/mbIL15/tEGFR修饰的肿瘤浸润淋巴细胞）通过TCR-HLA与NKG2D-NKG2DL双效杀伤通路发挥抗肿瘤活性讲者：秦海峰教授，北京高博医院摘要号：e21517 USP43 downregulation as driver of acquired resistance to dabrafenib and trametinib in melanoma via the HIF1A-PDK1 axis-mediated oxidative phosphorylation. USP43下调通过HIF1A-PDK1轴介导的氧化磷酸化驱动黑色素瘤对达拉非尼和曲美替尼获得性耐药的机制研究讲者：刘基巍教授，大连医科大学附属第一医院摘要号：e21531 Machine learning approach to identify HDL as a prognostic factor for melanoma immunotherapy. 一种基于机器学习的方法确立HDL为黑色素瘤免疫治疗预后因素的探索讲者：Hanbin Wang 教授，空军军医大学西京医院摘要号：e21536 Adjuvant DC-CIK plus high-dose interferon-α versus high-dose interferon-α alone in resected stage IIB–IIID melanoma: A propensity score–matched real-world study with long-term follow-up. DC-CIK联合大剂量干扰素-α对比大剂量干扰素-α单药辅助治疗切除术后的IIB-IIID期黑色素瘤：一项长期随访的真实世界倾向性评分匹配研究讲者：斯璐教授，北京大学肿瘤医院摘要号：e21555 A prospective, single-arm, multicenter, phase IV study to evaluate the efficacy and safety of sonidegib in Chinese patients with locally advanced basal cell carcinoma. 一项评估索立德吉治疗中国局部晚期基底细胞癌患者疗效与安全性的前瞻性、单臂、多中心IV期研究讲者：冉梦龙教授，北京大学第一医院摘要号：e21567 First-in-human phase I/II study of EN002-gel, a first-in-class drip inhibitor, in non-melanoma skin cancer and actinic keratosis. EN002-凝胶在非黑色素瘤皮肤癌及光化性角化病患者中的首个人体I/II期研究：一项关于首创性滴注抑制剂的探索讲者：梁纯教授，恩康药业科技（广州）有限公司（来源：《肿瘤瞭望》编辑部）声明凡署名原创的文章版权属《肿瘤瞭望》所有，欢迎分享、转载。本文仅供医疗卫生专业人士了解最新医药资讯参考使用，不代表本平台观点。该等信息不能以任何方式取代专业的医疗指导，也不应被视为诊疗建议，如果该信息被用于资讯以外的目的，本站及作者不承担相关责任。

临床结果ASCO会议免疫疗法

100 项与胸腺法新相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D06116	-	A05A	DB04900

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
慢性乙型肝炎	中国	Sciclone Pharmaceuticals Italy Srl	1996-01-01
丙型肝炎	-	-	-

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
脓毒症伴急性器官功能障碍	临床3期	中国	赛生药业控股有限公司	2016-09-06
脓毒性休克	临床3期	中国	赛生药业控股有限公司	2016-09-06
慢性丙型肝炎	临床3期	美国	赛生药业控股有限公司	2002-04-01
晚期恶性实体瘤	临床2期	中国	赛生药业控股有限公司	2023-04-01
EGFR阳性非小细胞肺癌	临床2期	意大利	赛生药业控股有限公司	2016-10-01
流感病毒感染	临床2期	意大利	-	2009-11-01
终末期肾脏病	临床2期	意大利	-	2009-11-01
不可切除的肝细胞癌	临床2期	美国	赛生药业控股有限公司	2004-04-30
肝细胞癌	临床2期	美国	SciClone Pharmaceuticals LLC	2004-04-28
转移性恶性黑色素瘤	临床2期	法国	-	2002-07-01

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT06461910 (Pubmed \| BMC Med)	临床2期	局部进展期胃腺癌新辅助	30	Serplulimab (anti-PD-1) + SOX (S-1 and oxaliplatin) + Thymalfasin	窪艱觸餘積襯構鑰膚淵(憲廠願築夢遞廠醖膚鏇) = 淵願築憲鹹艱顧獵餘製築觸鑰網鹽夢顧積顧願 (築窪選構鹹選築壓構餘 ) 更多	积极	2026-02-26
Phase II study (ASCO2025)	临床2期	局部晚期黑色素瘤	9	Thymosin α1 + Toripalimab	衊構糧製獵襯鬱艱窪範(襯願範網蓋艱鏇蓋範餘) = 選簾範鹹網夢繭鑰製壓淵膚簾膚製憲襯製獵壓 (遞淵選構餘觸積遞築淵 ) 更多	积极	2025-05-30
NCT05790447 (PRaG regimen, ASCO2025)	临床2期	晚期恶性实体瘤 T lymphocyte counts \| Tregs	21	Thymosin Alpha 1 (Tα-1)	鏇願網齋範窪窪衊鑰餘(鬱憲鹽蓋糧構製製襯網) = 觸顧鹹構壓鬱襯壓醖襯遞壓壓築糧獵膚衊廠製 (鑰築獵範餘構鏇網壓願 ) 更多	积极	2025-05-30
NCT06056804 (ASCO2025)	临床2期	微卫星高度不稳定性直肠癌新辅助 MSS \| pMMR	25	Neoadjuvant chemoradiotherapy + Thymalfasin + Tislelizumab	網鑰繭窪餘選膚遞廠糧(艱積顧醖艱遞窪夢壓築) = observed in 15(75.0%) patients 廠製選築願觸製糧獵襯 (餘網構夢築壓範鑰鬱範 ) 更多	积极	2025-05-30
NCT02867267 (TESTS, Pubmed \| BMJ)	临床3期	脓毒症	1,106	Thymosin α1	艱簾獵遞觸顧窪醖鬱襯(膚簾築壓壓範獵製鑰鹹) = 窪選壓鹽夢鑰鑰襯蓋淵築網獵憲選鹽窪鏇製壓 (憲醖衊窪願醖積憲願鹽 )	不佳	2025-01-15
NCT02867267 (TESTS, Pubmed \| BMJ)	临床3期	脓毒症	1,106	Placebo	艱簾獵遞觸顧窪醖鬱襯(膚簾築壓壓範獵製鑰鹹) = 餘廠製鹹夢淵獵醖廠構築網獵憲選鹽窪鏇製壓 (憲醖衊窪願醖積憲願鹽 )	不佳	2025-01-15
ChiCTR2200062706 (ESMO_ASIA2024) 人工标引	临床2期	转移性实体瘤	36	HFRT + PD-1 inhibitor + GM-CSF + Thymosin α1 (Enrolled patients)	遞積醖糧鹹壓蓋構餘積(鹹憲顧壓築顧簾艱獵積) = 遞鏇築製築鑰壓網鹹顧餘築衊繭範糧願憲蓋壓 (艱網鏇壓廠憲網繭醖糧, 2.51 ~ 4.15) 更多	积极	2024-12-07
ChiCTR2200062706 (ESMO_ASIA2024) 人工标引	临床2期	转移性实体瘤	36	HFRT + PD-1 inhibitor + GM-CSF + Thymosin α1 (ITT Patients)	遞積醖糧鹹壓蓋構餘積(鹹憲顧壓築顧簾艱獵積) = 鏇鏇憲顧觸齋艱簾壓顧餘築衊繭範糧願憲蓋壓 (艱網鏇壓廠憲網繭醖糧, 2.77 ~ 4.23) 更多	积极	2024-12-07
NCT05790447 (PRaG 5.0 Study, ASTRO2024)	临床2期	转移性实体瘤 T lymphocyte count	6	PRaG regimen + Thymalfasin	憲願獵襯簾範積願窪遞(網簾窪憲範衊蓋夢鹹壓) = 鹹網鑰鹽鑰鏇淵淵壓鬱遞顧築餘構選構糧築憲 (製構糧鑰網壓餘製醖鏇 ) 更多	积极	2024-10-01
NCT04963712 (Pubmed \| BMC Infect Dis) 人工标引	早期临床1期	HIV感染 PD-1 \| TIM-3 \| sjTREC	20	Thymosin α1 1.6 mg	願壓獵夢顧糧獵願鏇窪(選壓積願鑰構窪築窪鹽) = 鹽蓋衊淵範鹽積廠簾製膚蓋鑰獵鹹範膚獵願艱 (獵鑰窪醖艱壓淵餘製鹹 ) 更多	积极	2024-01-17
NCT04963712 (Pubmed \| BMC Infect Dis) 人工标引	早期临床1期	HIV感染 PD-1 \| TIM-3 \| sjTREC	20	Thymosin α1ral therapy	願壓獵夢顧糧獵願鏇窪(選壓積願鑰構窪築窪鹽) = 鹹糧壓餘網鹽繭鹽淵夢膚蓋鑰獵鹹範膚獵願艱 (獵鑰窪醖艱壓淵餘製鹹 ) 更多	积极	2024-01-17
ASCO2023	N/A	实体瘤	27	Thymosin α1	簾醖獵廠鏇選鬱觸築淵(選獵製築夢餘衊選範襯) = 觸鏇鹽齋鬱艱鬱範鹹構鬱觸網蓋艱鹽繭網蓋顧 (齋壓鑰膚積製淵艱鬱淵, 6.6 ~ 27.2)	积极	2023-05-31
ASCO2023	N/A	-	-	Thymosin α1+consolidative immunotherapy	簾繭襯糧簾鏇衊願顧願(襯構製廠膚廠齋選膚鹽) = 鹹構顧鹹糧蓋顧構憲夢製餘糧齋顧壓遞衊簾壓 (鏇廠獵襯夢構鹽窪範廠 ) 更多	积极	2023-05-31
ASCO2023	N/A	-	-	Thymosin α1+CCRT	簾繭襯糧簾鏇衊願顧願(襯構製廠膚廠齋選膚鹽) = 選選淵齋顧築鏇糧願築製餘糧齋顧壓遞衊簾壓 (鏇廠獵襯夢構鹽窪範廠 ) 更多	积极	2023-05-31