西他生坦钠(Sitaxentan Sodium) - 药物靶点：ETA_在研适应症：系统性硬皮病，硬化症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Sitaxentan、Sitaxentan sodium (USAN)、Sitaxsentan

+ [11]

靶点

ETA

作用方式

拮抗剂

作用机制

ETA拮抗剂(内皮素A受体拮抗剂)

治疗领域

免疫系统疾病遗传病与畸形皮肤和肌肉骨骼疾病+ [1]

在研适应症

系统性硬皮病硬化症

非在研适应症

慢性肾病心脏病舒张期心力衰竭+ [5]

原研机构

Pfizer Inc.

在研机构

Timber Pharmaceuticals LLC

非在研机构

Pfizer Inc.Pfizer Ltd.

Encysive Pharmaceuticals, Inc.

权益机构-

最高研发阶段临床前

首次获批日期

欧盟 (2006-08-10),

肺性高血压肺动脉高压

最高研发阶段(中国)终止

特殊审评孤儿药 (美国)

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结构/序列

分子式C18H15ClN2NaO6S2

InChIKeyHRFIVLUXADNCHX-UHFFFAOYSA-N

CAS号210421-74-2

关联

26

项与西他生坦钠相关的临床试验

CTRI/2023/11/060042

/ CompletedN/A

A Retrospective Multicenter Real-World Evidence Study of Open, Laparoscopic and Robotic-assisted Staging Surgery for Endometrial Cancer - NIL

开始日期2023-11-30

申办/合作机构-

NCT04976894

/ Active, not recruitingN/AIIT

Korean Stroke Cohort for Functioning and Rehabilitation-II

Korean Stroke Cohort for functioning and rehabilitation (KOSCO)-II is a large, multi-centre prospective cohort study for all acute first-ever stroke patients admitted to participating hospitals in nine distinct areas of Korea. This study is designed as a 10-year, longitudinal follow-up investigating the residual disabilities, activity limitations, and quality of life issues arising in patients suffering from first-ever stroke as previous similar stroke cohort with KOSCO. The main objectives of this study are to identify and compare the factors that influence residual disability and long-term quality of life in first-ever acute stroke patients with KOSCO. The secondary objectives of this study are to determine and compare the risk of mortality and recurrent vascular events in first-ever acute stroke patients with KOSCO. Investigators will investigate longitudinal health behaviors and patterns of healthcare utilization, including stroke rehabilitation care. Investigators will also investigate the long-term health status, mood, and quality of life in stroke patient caregivers. In addition, investigators will identify baseline and ongoing characteristics that are associated with secondary outcomes.

开始日期2020-01-01

申办/合作机构

Samsung Medical Center

NL-OMON46715

/ Completed临床3期IIT

Distal pancreatectomy, minimally invasive or open, for malignancy (DIPLOMA) - DIPLOMA-trial

开始日期2018-05-03

申办/合作机构-

100 项与西他生坦钠相关的临床结果

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100 项与西他生坦钠相关的转化医学

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100 项与西他生坦钠相关的专利（医药）

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292

项与西他生坦钠相关的文献（医药）

2025-10-01·BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Harnessing integrated bioinformatics to identify new diagnostic and therapeutic strategies for heart failure

Article

作者: Wang, Ruilin ; Shang, Min ; Sun, Shuo ; Fu, Guosheng ; Huang, Chengchen ; Lai, Chaojie

Heart failure (HF) is a life-threatening condition that poses a significant challenge on public health, particularly among the elder populations. To develop new diagnostic and therapeutic strategies for HF, we analyzed large-scale transcriptome sequencing data from HF patients as an exploratory approach. We identified 18 HF-related genes and developed a robust scoring model for HF diagnosis, by applying two machine learning algorithms for data analysis. Meanwhile, we evaluated and compared the predictive abilities of three bioinformatics methods in identifying potential HF treatment drugs. Significantly, an unconventional network-based proximity analysis, integrating multidimensional drug target information, outperformed other methods in the assessment of predictive ability. To validate these findings, we tested several candidate drugs in a mouse model transitioning from acute myocardial infarction (MI) to chronic HF. Among the candidates, mirtazapine exhibited cardioprotective effects in both early (1-week) post-MI and chronic HF (4-week post-MI) settings, while cabergoline showed potential efficacy primarily in the early post-MI phase. Additionally, the screened triamterene, used as a positive control, exhibited protective effects in both early post-MI and chronic HF stages. Mechanistic studies revealed that growth factor receptor-bound protein 14 and Ras-related protein Rab-3A were critical to the observed cardioprotection. These findings provide valuable evidence and insights for exploring potential therapeutic agents for HF treatment.

2025-10-01·JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Cardiopulmonary bypass–mediated lung ischemia–reperfusion injury: A protective role of sitaxentan

Article

作者: Chen, Yirong ; Wang, Zhengjia ; Mo, Liqun ; Liu, Li ; Bai, Yiping ; Zhan, Renshu ; Zhang, Yingying

Background:

Cardiopulmonary bypass is widely used in cardiac surgery but often leads to lung ischemia–reperfusion injury, a major cause of morbidity and mortality. Despite advances in critical care, effective prevention remains challenging. Sitaxentan, a selective endothelin receptor antagonist, has shown protective effects in ischemia–reperfusion models, suggesting its potential in mitigating lung ischemia–reperfusion injury. This study investigated the efficacy of sitaxentan in reducing lung ischemia–reperfusion injury during cardiopulmonary bypass.

Methods:

Twenty-four female beagles were divided into sham, cardiopulmonary bypass, and endothelin receptor antagonist (sitaxentan-treated) groups. Hemodynamics, arterial blood gas, lung damage scores, wet/dry ratio, and levels of various biomarkers were evaluated.

Results:

Lung damage scores in the endothelin receptor antagonist group were lower than those in the cardiopulmonary bypass group but higher than those in the sham group ( P < 0.05). The wet/dry ratio was lowest in the sham group and higher in the cardiopulmonary bypass group than that in the endothelin receptor antagonist group ( P < 0.05). Caspase-3 and hypoxia inducible factor-1α levels were intermediate in the endothelin receptor antagonist group compared with those in the cardiopulmonary bypass and sham groups ( P < 0.05). In contrast, phosphorylated-endothelial nitric oxide synthase, phosphorylated protein kinase B, tumor necrosis factor-α, and interleukin-6 levels were higher in the endothelin receptor antagonist group than in the cardiopulmonary bypass and sham groups ( P < 0.05). Malondialdehyde level was higher and superoxide dismutase level was lower in the cardiopulmonary bypass and endothelin receptor antagonist groups than in the sham group ( P < 0.05).

Conclusions:

Sitaxentan may offer a novel therapeutic approach to attenuate lung ischemia–reperfusion injury in clinical settings by regulating the hypoxia inducible factor-1α/phosphorylated protein kinase B/phosphorylated-endothelial nitric oxide synthase pathway.

2024-11-01·Journal of Computational Biophysics and Chemistry

Molecular Docking, Quantum Mechanics and Molecular Dynamics Simulation of Anti-CAD Drugs Against High-Risk Xanthine Dehydrogenase Variants Associated with Oxidative Stress Pathways

作者: Sudhan, M. ; Ahmed, Shiek S. S. J. ; Emran, Talha Bin ; Attia, Sabry M. ; Ahmad, Sheikh F. ; Janakiraman, V.

Xanthine dehydrogenase (XDH) contributes significantly to generating reactive oxygen species in coronary artery disease (CAD). XDH has been proposed as a therapeutic target, but its genetic variants could affect protein structure and drug response. We aimed to assess protein structure modification occur due to genetic variants and to screen 215 CAD drugs for their utility in personalized CAD treatment against the XDH variants. A series of computational methods were implemented to identify pathogenic variants that cause XDH structure instability localized at the con served regions contributing to functional significance. Then, the XDH structures with the pathogenic variants were modeled using two different approaches to select the best models for docking with the CAD drugs. Finally, the stability of the docked complexes and their ability to transfer electrons were evaluated using molecular dynamics (MD) simulations and quantum mechanics/molecular mechanics (QM/MM) calculation. Among 751 variants examined; R149C and Q919R showed high pathogenicity, localized in conserved regions could alter protein structure and function. Further, docking of CAD drugs against XDH (native, R149C and Q919R) showed vericiguat with higher affinity, ranging from −7.95 kcal/mol to −10.41 kcal/mol, than the well-known XDH inhibitor (febuxostat, −5.73 kcal/mol to −8.35 kcal/mol). This indicates that vericiguat will be effective in CAD treatment, regardless of the XDH variants. Additionally, MD simulation and QM/MM confirmed vericiguat stability and electron transfer ability to form hydrogen bonds with the XDH protein. In conclusion, vericiguat will be beneficial for the personalized treatment of CAD by inhibiting XDH variants. Additional clinical studies are necessary to confirm our findings.

9

项与西他生坦钠相关的新闻（医药）

2024-08-22

·Pharmaceutical Technology

Leo Pharma’s Timber bet falls flat following Phase III failure

There is currently no treatment approved for ichthyosis by the FDA. Image credit: Shutterstock / JHVEPhoto. A year after hedging its bets on Timber Pharmaceuticals’ dermatology pipeline, Leo Pharma has reported a Phase III failure for the lead asset it acquired at the time. TMB-001, a topical ointment formulation of isotretinoin, came up short in the late-stage trial for patients with moderate to severe congenital ichthyosis. Ichthyosis is an umbrella term for congenital skin conditions that cause dry and scaly skin. In the Phase III ASCEND trial (NCT05295732), Leo stated the therapy did not demonstrate a statistically significant improvement in patients compared to those treated with a vehicle. This meant the primary and key secondary endpoints were not met. The results do not support US regulatory submission, the Danish privately owned company stated in a 21 August press release. There is currently no treatment approved for ichthyosis by the US Food and Drug Administration (FDA). Instead, the condition is managed by hydrating the skin with creams and lotions. See Also: A comprehensive guide to supply chain management for specialty drugs Codiak BioSciences gets grant for extracellular vesicles for disease treatment and prevention The ASCEND trial had a three-week induction, a nine-week treatment period, and – for eligible patients – a 12-week open-label maintenance regimen. A total of 209 patients aged six years and over were enrolled in the study. Timber’s CEO John Koconis said: “We are disappointed and saddened by the results of the Phase III trial. After encouraging phase 2b results, we observed an unexpectedly high vehicle response in this trial.” A previous Phase IIb trial evaluating the ointment achieved its primary endpoint of a 50% reduction in the Visual Index for Ichthyosis Severity scale score versus baseline. Leo Pharma spent $36m to acquire a bankrupt Timber in August 2023, including a $14m upfront payment. At the time, Timber had received orphan, fast-track, and breakthrough designations from the FDA. Following the acquisition, the company became a fully owned subsidiary of Leo Pharma. Leo Pharma’s chief development officer Kreesten Meldgaard Madsen said the company remains committed to dermatologic diseases but added “as is the case for all pharmaceutical research, not all trials are successful”. Leo Pharma stated the trial results will not impact its 2024 financial results. The company had a regulatory win elsewhere in the dermatology space in June this year, when its single-dose autoinjector for atopic dermatitis Adbry (tralokinumab-ldrm) received FDA approval . Whilst the clinical journey of TMB-001 stutters, Timber also has TMB-003 (sitaxentan) – a topical ET-A receptor antagonist in preclinical testing for sclerotic skin diseases.

临床2期临床3期临床结果快速通道突破性疗法

2024-05-14

·药融圈

值得关注的治疗领域：皮肤制药公司被并购

▲5月30-31日第八届广州生物医药创新者峰会扫码立即报名注：本文不构成任何投资意见和建议，以官方/公司公告为准；本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及），不代表平台立场。任何文章转载需得到授权。丹麦制药巨头利奥制药（LEO）是一家引领标准治疗，惠及皮肤疾病患者及其家庭和社会的全球公司。值得留意的是利奥制药的创始人August Kongsted是诺和诺德之Nordisk的天使投资人。LEO是一家超百年的企业；成立于1908年，隶属于利奥基金会，数十年来一直致力于研发，以推动皮肤病科学的发展。如今，利奥制药为不同严重程度的疾病提供了广泛的治疗方案。利奥制药总部位于丹麦，拥有全球员工4600人，为全球数千万患者提供服务。2022年利奥制药的净销售收入为106亿丹麦克朗（约合110亿元人民币）。药融云数据www.pharnexcloud.com监测显示：2024年1月，利奥制药完成对Timber Pharmaceuticals（纽约证券交易所股票代码：TMBR）的战略资产TMB-001及其他资产的收购。（要知道停牌收购前市值仅117万美元）药融圈获悉：该交易的总交易价值3600万美元（约合2.605亿人民币），其中（i）初始预付对价为1400万美元，（ii）在实现特定里程碑后，可额外支付至多2200万美元的或有价值权（CVR）。TMB-001项目旨在开发一种外用药物治疗方法，用于治疗多种中度至重度亚型先天性鱼鳞病（Congenital Ichthyosis ,CI）--一种罕见的皮肤病，存在大量未被满足的需求，且尚无正规获批的处方疗法（off-label 此前居多）。TMB-001项目按原计划继续进行。Timber Pharmaceuticals的所有员工将迁移至利奥制药位于美国新泽西州的办公室。 Timber专注于开发罕见皮肤病的非全身性治疗方法，包括先天性鱼鳞病（CI）和硬化性皮肤病（sclerotic skin diseases）。药融云数据www.pharnexcloud.com；词条TMB-001是一种活性药物成分（API）为异维甲酸/异维A酸的研究性外用制剂（改良新药）（关联阅读：505b2是否会是诗和远方？），目前美国只有异维甲酸的口服制剂。该新制剂已获得FDA的孤儿药项目资质；快速通道和突破性疗法的认证。TMB-001在II期临床研究已显示出积极的结果，III期临床研究的招募工作目前正在美国和欧洲进行。Timber Pharmaceuticals另一款候选药物Sitaxsentan 是选择性内皮素A (ETA) 受体拮抗剂，适应症为硬化性皮肤病。此前Christophe Bourdon/利奥制药CEO表示：“我们很高兴在2024年将TMB-001加入我们的产品线，并欢迎Timber Pharmaceuticals的员工加入利奥制药。这项交易将进一步加强我们的产品管线，使我们拥有一项具有战略意义的Ⅲ期资产，并可能有助于目前患有尚无合适治疗方案的衰竭性疾病患者的治疗。”参考：NMPA/CDE；药融云数据www.pharnexcloud.com；FDA/EMA/PMDA；相关公司公开披露；利奥制药（LEO）；www.timberpharma.com；https://www.timberpharma.com/tmb-003-topical-subcutaneous-et-a-r；等等。本文仅用于向医疗卫生专业人士提供科学信息，不代表平台立场，不作任何用药推荐5月 • 第八届大湾区生物医药创新者峰会

并购孤儿药突破性疗法临床3期临床2期

2024-04-10

·赛柏蓝

全新机制高血压用药上市，院内降压药排名大洗牌？

编者按：本文来自医药地理，作者南波万；赛柏蓝授权转载，编辑凯西2024年3月20日，Idorsia 宣布FDA已批准TRYVIO™（Aprocitentan）与其他抗高血压药物联合用于治疗其他药物未得到充分控制的成年患者的高血压（难治性高血压）。TRYVIO（Aprocitentan）是一款新型口服双重内皮素A/B受体（ETA/ETB）拮抗剂，可有效抑制内皮素ET-1与ETA和ETB的结合。在TRYVIO获得批准之前，没有针对ET通路的全身性抗高血压药物，Tryvio®是近40年来获得批准的通过新的治疗途径起作用的首款口服抗高血压治疗剂。01获批的临床试验FDA此次批准是依据一项临床Ⅲ期研究PRECISION（NCT03541174）的试验结果。该研究是一项多中心、盲法、随机临床试验，评估了Approcitentan在收缩压≥140 mmHg且至少服用三种降压药的成年人中的疗效。图：PRECISION III期临床试验来源：Pharma ONE智能药物大数据分析平台，中国医药工业信息中心结果显示，该研究达到了主要终点，即Aprocitentan组患者的坐位收缩压（SiSBP）降低幅度显著大于安慰剂组。即接受Aprocitentan治疗的患者4周后SiSBP得到显著降低，与安慰剂组相比，12.5mg组和25mg组的差异分别为-3.8mmHg（p=0.0042）和-3.7mmHg（p=0.0046）。此外，该研究也达到了关键次要终点，在第36~40周期间，接受Aprocitentan治疗的患者的SiSBP较安慰剂组持续降低，差异为-5.8mmHg（p<0.0001），维持时间长达48周。02作用机制内皮素（ET）是一种强效肽类血管收缩剂，其收缩血管的能力比去甲肾上腺素强100倍。ET是由21个氨基酸组成的活性多肽，有ET-1、ET-2和ET-3三种亚型，其受体分为ETA和ETB。ET-1是ET肽家族中最主要的成员，主要在血管内皮细胞和培养的平滑肌细胞中合成，其与高血压发病机制密切相关，可引起交感神经激活、醛固酮合成和分泌增加、内皮功能障碍、血管肥大和重塑以及纤维化。Aprocitentan是一款靶向双重ETA/ETB受体拮抗剂，通过阻断ET-1与血管平滑肌细胞上的ETA和ETB受体的结合，抑制血管收缩，起到降低血压的作用。图：Aprocitentan的作用机制03内皮素拮抗剂市场情况顽固性高血压是指在改善生活方式的基础上，完全依从降压药物（至少3种）治疗后，血压水平仍高于目标水平的心血管疾病。内皮素（ET）途径在顽固性高血压的发展中起关键性作用。除了高血压，大量研究表明内皮素在冠心病、肺动脉高压、心衰、脑梗死、动脉粥样硬化、多发性硬化、肾病综合征、类风湿性关节炎、糖尿病等多种疾病的发生发展过程中有着较为重要的病理生理意义。不仅如此，内皮素受体还具有与细胞增殖和凋亡等基本细胞过程相关的多种功能，因此，内皮素受体也成为癌症治疗的关键靶点。ET受体拮抗剂可能有益于多种疾病的治疗，具有重要的临床治疗价值。截至目前，FDA共批准了6款ETA/ ETB拮抗剂，其中大部分药品获批的适应症为肺动脉高压，包括2001年获批上市用于治疗肺动脉高压的首创药物ETA+ ETB双重拮抗剂Bosentan（波生坦）；2006年曾获批上市的Sitaxentan（西他生坦），由于在报告中观察到暴发性肝毒性后已被撤市；2007年获批用于治疗肺动脉高压的ETA受体选择性拮抗剂Ambrisentan (安立生坦)；2013年获批同样用于治疗肺动脉高压的ETA+ETB双重拮抗剂Macitentan（马昔腾坦），Aprocitentan是Macitentan的活性代谢产物，具有更长的半衰期（48h vs. 14h）；2023年获批用于治疗IgA肾病的ETA+AT1R双重拮抗剂Sparsentan（斯巴生坦）。而此次Aprocitentan（阿普昔腾坦）是FDA批准的第六款内皮素受体拮抗剂，也是其中第一款适应症为治疗高血压的药物。042023样本医院降压药排名目前市场上常见的降压药按照其作用机制分为ACE抑制剂（血管紧张素转换酶抑制剂）、ARBs（血管紧张素Ⅱ受体拮抗剂）、钙通道阻滞剂、利尿剂、β受体阻滞剂以及中枢性α受体激动剂等。2023年全国样本医院用药市场（包含全国24个省/市/自治区近700家二三级医院药品采购数据）中高血压化药销售额约为64.53亿元。样本医院排名前10的药品（按通用名计）中，表现最为亮眼的无疑是诺华的沙库巴曲缬沙坦钠片（商品名：诺欣妥），不仅一举超过硝苯地平和美托洛尔，以7.89亿元的销售额位居榜首，而且其增速同样十分迅猛，较去年同比增长约51%。沙库巴曲缬沙坦钠片是全球首个血管紧张素受体脑啡肽酶抑制剂（ARNI），于2015年7月获FDA批准上市用于治疗心衰，2017年获NMPA批准进入国内市场，2019年起进入国家医保乙类谈判目录，2021年在中国率先获批用于原发性高血压治疗。诺华在中国市场为诺欣妥分别申报了组合物专利（专利号：ZL201110029600.7）和晶型专利（专利号：ZL200680001733.0/ZL201210191052.2），尤其是独特的晶型专利让诺欣妥在中国市场的独占期可持续到2026年11月。2023年8月，南京方生和医药的一心坦采用了3个结晶水的新晶型，规避了原研含有2.5个结晶水的晶型专利障碍，从而实现了仿制药的合法提前上市，成为沙库巴曲缬沙坦钠片的首仿药。表：诺欣妥在中国专利布局相比之下，去年销售冠军硝苯地平的表现就有些不理想，销售额下滑明显，同比下降约66%，排名跌落至第六名。同样，美托洛尔销售额也下滑明显（-42%），从第二名跌至第三名。表：2023样本医院治疗高血压化药销售额TOP 10来源：PDB药物综合数据库，中国医药工业信息中心05小结与展望Aprocitentan以全新的机制进入高血压药赛道，其降压效果究竟如何还有待市场的进一步检验。除此之外，近年来，长效高血压药的概念也十分火热，Zilebesiran作为一种皮下给药、一针管半年、靶向血管紧张素原（AGT）的在研RNAi治疗药物，一直备受关注。日前正在进行的2024年美国心脏病学会（ACC）年会上，Alnylam公司公布了与罗氏联合开发的zilebesiran在治疗高血压患者的II期临床试验KARDIA-2中获得的积极结果。结果显示，表明对于高血压控制不佳患者，zilebesiran与标准降压药联用，可带来额外的降压获益，降压效果可维持6个月。图：KARDIA-2试验设计来源：Alnylam官网根据《中国高血压临床实践指南》，中国成人高血压人数约2.45亿，且越来越年轻化和普遍化，血压的防控至关重要。期待这些新机制的降压药物能尽早进入中国市场，惠及更多中国患者。END内容沟通：13810174402医药代表交流群扫描下方二维码加入银发经济市场机遇交流群扫描下方二维码加入左下角「关注账号」，右下角「在看」，防止失联

临床结果临床3期临床成功

100 项与西他生坦钠相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D08517	西他生坦钠	C02KX03	DB06268

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
肺性高血压	欧盟	Pfizer Ltd.	2006-08-10
肺性高血压	冰岛	Pfizer Ltd.	2006-08-10
肺性高血压	列支敦士登	Pfizer Ltd.	2006-08-10
肺性高血压	挪威	Pfizer Ltd.	2006-08-10
肺动脉高压	欧盟	Pfizer Ltd.	2006-08-10
肺动脉高压	冰岛	Pfizer Ltd.	2006-08-10
肺动脉高压	列支敦士登	Pfizer Ltd.	2006-08-10
肺动脉高压	挪威	Pfizer Ltd.	2006-08-10

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
特发性肺动脉高压	临床3期	美国	Encysive Pharmaceuticals, Inc.	2003-05-01
僵硬	临床2期	英国	Encysive Pharmaceuticals, Inc.	2007-07-14
慢性肾病	临床2期	英国	Pfizer Inc.	2007-05-09
蛋白尿	临床2期	英国	Pfizer Inc.	2007-05-09
心脏病	临床2期	美国	Pfizer Inc.	2006-08-10
舒张期心力衰竭	临床2期	美国	Pfizer Inc.	2006-03-27
舒张期心力衰竭	临床2期	加拿大	Pfizer Inc.	2006-03-27
系统性硬皮病	临床前	美国	Timber Pharmaceuticals LLC	2022-01-30
硬化症	临床前	美国	Timber Pharmaceuticals LLC	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00810732 (FCRD01, CTgov)	临床2期	蛋白尿 \| 僵硬 \| 慢性肾病	27	Open (Sitaxsentan)	壓鹹鹹遞選網醖範醖簾(築糧蓋鏇憲夢構醖淵膚) = 襯構窪範壓願願網鑰鏇蓋簾艱廠鹹網獵衊壓夢 (淵築糧鹹獵襯築鏇構齋, 1.77) 更多	-	2023-07-06
				Placebo (Placebo)	壓鹹鹹遞選網醖範醖簾(築糧蓋鏇憲夢構醖淵膚) = 窪製艱構鏇願窪獵窪鹽蓋簾艱廠鹹網獵衊壓夢 (淵築糧鹹獵襯築鏇構齋, 1.96) 更多
NCT00303498 (CTgov)	临床2期	舒张期心力衰竭	200	Placebo	壓醖淵艱淵範廠網鹽淵(積鬱夢範蓋憲壓繭膚構) = 網獵網廠鹹網獵顧廠蓋壓獵齋範膚壓壓蓋製淵 (積鬱鏇願鹹齋積鹽鑰簾, 蓋鬱鑰網窪壓窪繭簾簾 ~ 觸醖構鬱膚鹹製願襯網) 更多	-	2023-01-04
NCT00838383 (FCAD02, CTgov)	临床2期	心脏病	29	Placebo	齋積淵積鹹製網齋鹽齋(鏇繭願憲製糧鑰窪遞網) = 膚鏇繭壓鹽襯鑰遞齋積艱簾鬱醖築窪鹽膚蓋願 (窪醖艱鏇鹹範願餘構襯, 260.172) 更多	-	2022-09-08
NCT00744211 (CTgov)	N/A	心脏病	29	Vehicle (Vehicle)	顧衊鬱廠夢夢築淵願觸(願選窪憲獵鹹範鑰壓鑰) = 夢顧積築夢艱壓鹹鬱窪齋遞餘簾範夢廠糧淵鑰 (衊壓廠窪鏇鹽艱衊廠構, 19.9) 更多	-	2017-11-09
				1mg/kg sitaxsentan sodium (ET-ARA 1mg/kg)	夢繭鏇簾顧衊選築醖築(獵襯獵遞糧膚鹽衊觸製) = 觸鹹構鑰鏇襯顧夢願醖構衊遞網鹹鬱製淵壓鹹 (鬱窪構繭鹹遞憲壓廠觸, 積範築範鹹鏇範夢築鑰 ~ 顧鬱壓餘範鏇淵鑰鹽糧) 更多
NCT00810732 (Pubmed \| J Am Heart Assoc)	临床2期	慢性肾病	27	Sitaxentan	鹹齋蓋遞選繭製顧網襯(範膚醖醖齋齋鏇夢衊鑰) = 窪淵餘範願襯鏇構壓鑰簾淵製製獵壓鏇鹽獵淵 (襯餘蓋選膚蓋鬱簾淵選 ) 更多	-	2015-03-23
NCT00303498 (Pubmed \| JACC Heart Fail)	临床2期	舒张期心力衰竭	192	Sitaxsentan 100 mg/day	製鏇觸鬱壓壓衊構淵鏇(蓋鬱蓋網遞蓋艱鬱構網) = 夢構鹹網憲憲遞夢築簾壓淵蓋餘膚積鬱壓膚鑰 (鹽鏇壓獵醖艱鏇構網簾 )	不佳	2014-04-01
				Placebo	製鏇觸鬱壓壓衊構淵鏇(蓋鬱蓋網遞蓋艱鬱構網) = 遞製窪簾鬱鹽獵積築窪壓淵蓋餘膚積鬱壓膚鑰 (鹽鏇壓獵醖艱鏇構網簾 )
ERS2013	N/A	肺动脉高压	285	Bosentan	構顧鬱壓網衊願選醖鹽(憲醖鬱選網獵壓淵蓋製) = 齋顧夢餘鏇憲壓齋積糧衊觸鏇選鏇繭繭餘壓遞 (網膚廠顧鹽襯襯觸網築 ) 更多	积极	2013-09-01
				Ambrisentan	構顧鬱壓網衊願選醖鹽(憲醖鬱選網獵壓淵蓋製) = 淵夢廠襯衊簾衊構糧築衊觸鏇選鏇繭繭餘壓遞 (網膚廠顧鹽襯襯觸網築 ) 更多
NCT00811018 (STRIDE-3, CTgov)	临床3期	肺动脉高压	1,192	Sitaxsentan	膚憲鹹選餘襯鏇鏇餘獵 = 窪獵築鹹鑰糧夢繭衊膚餘餘網範艱鹽築鹹膚遞 (獵淵衊鹽廠遞壓膚鑰壓, 憲憲願餘築鹽廠簾鏇廠 ~ 廠襯顧網選築選顧簾範) 更多	-	2012-04-24
NCT00795639 (CTgov)	临床3期	肺动脉高压	183	Sitaxsentan	範製網糧鏇繭襯襯憲觸(鏇齋鬱艱餘鹹醖構構鬱) = 顧壓遞鹽齋憲鏇鹹遞醖製膚廠選淵鹹構網窪醖 (廠齋築觸觸餘襯繭廠憲, 鹹遞獵窪鑰憲獵鹽積衊 ~ 構廠簾壓襯鏇艱廠鹹糧) 更多	-	2012-03-01
NCT00796666 (CTgov)	临床3期	肺动脉高压	131	Sitaxsentan (Sitaxsentan and Placebo)	簾築鹽衊鬱糧醖網繭艱(鬱簾蓋憲網遞膚鬱鹹廠) = 廠淵艱製膚選淵衊蓋顧襯壓膚鬱鑰糧遞選蓋遞 (鏇艱積廠遞夢積壓窪觸, 餘蓋鏇淵齋願窪鹹鏇遞 ~ 壓膚遞衊鹹醖選窪遞遞) 更多	-	2012-02-29
				Sildenafil+Sitaxsentan (Sitaxsentan and Sildenafil)	簾築鹽衊鬱糧醖網繭艱(鬱簾蓋憲網遞膚鬱鹹廠) = 壓夢遞糧夢壓鹹簾構蓋襯壓膚鬱鑰糧遞選蓋遞 (鏇艱積廠遞夢積壓窪觸, 簾艱夢願廠顧選窪範鏇 ~ 憲積選艱構觸範繭糧鏇) 更多