AS 900672-Enriched(AS 900672-Enriched) - 药物靶点：FSHR_专利_临床

概要

基本信息

药物类型

多肽激素

别名

Follicle-stimulating hormone analogue、FSH analogue、Glycosylated recombinant follicle-stimulating hormone

+ [3]

靶点

FSHR

作用方式

激动剂、刺激剂

作用机制

FSHR激动剂(卵泡刺激素受体激动剂)、卵泡刺激

治疗领域

泌尿生殖系统疾病

在研适应症-

非在研适应症

不孕

原研机构

Merck Serono SA

在研机构-

非在研机构

Merck KGaA

权益机构-

最高研发阶段终止临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

4

项与 AS 900672-Enriched 相关的临床试验

NCT01080729

/ TerminatedN/A

A Prospective, Observational and Multicentric Study to Compare the Dose of GONAL-fTM FbM Prescribed by the Doctor With the Recommendation of the Dose Calculator Consort and to Evaluate the Ease of Use of Pre-filled Pen of GONAL-fTM FbM Pen

This is a prospective, observational and multicentric study to compare the Gonal-f FbM (filled by mass) dose prescribed by the doctor with the Gonal-f FbM dose determined by the CONSORT (Consistency in r-FSH Starting doses for individualized treatment) calculator.

开始日期2009-02-01

申办/合作机构

Merck KGaA

[+1]

NCT01075815

/ Terminated临床2期

Exploratory Study to Determine the Effect of Lutropin Alfa on Embryo Quality and Their Implantation in Women of Advanced Reproductive Age

This is a multicentric, open, randomized, comparative trial aimed to assess the influence of recombinant luteinizing hormone (r-LH) supplementation during controlled ovarian stimulation (COS) in advanced reproductive age in terms of improved embryo competence which allows to transfer less embryos to avoid high grade multiple pregnancy without reducing the pregnancy rate.

开始日期2008-11-01

申办/合作机构

Merck KGaA

[+1]

NCT00553514

/ Terminated临床2期

A Phase II, Multicentre, Randomised, Assessor-blinded, Active-comparator, Parallel-group Dose Finding Trial to Evaluate AS900672-enriched Versus Follitropin Alfa (GONAL-f®) in Oligo-anovulatory Infertile Women Undergoing Ovulation Induction (OI)

This is a Phase 2, interventional, multi-center, randomized, assessor-blind, active-comparator, dose-finding study to evaluate a new investigational long-acting follicle stimulating hormone (FSH) in oligo-anovulatory women undergoing ovulation induction (OI). This study will compare 4 doses of the investigational drug versus a currently marketed drug follitropin alfa (Gonal-f ®) prefilled pen with regards to ovulation rate.

开始日期2007-12-01

申办/合作机构

Merck KGaA

100 项与 AS 900672-Enriched 相关的临床结果

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100 项与 AS 900672-Enriched 相关的转化医学

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100 项与 AS 900672-Enriched 相关的专利（医药）

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100 项与 AS 900672-Enriched 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
不孕	临床2期	美国	Merck KGaA	2007-01-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00553514 (CTgov)	临床2期	不孕	71	Recombinant human chorionic gonadotropin (r-hCG)+AS900672-Enriched 10 microgram (mcg)+Follitropin alfa (AS900672-Enriched 10 Mcg)	鏇築觸餘齋範鑰膚廠鹹 = 築觸蓋製憲鹹範廠膚築範築窪願選壓壓壓衊膚 (選觸膚鹽積鑰糧齋餘齋, 製鬱鑰齋襯淵鑰鹽憲膚 ~ 選糧衊顧襯夢襯鬱製遞) 更多	-	2013-07-25
				Recombinant human chorionic gonadotropin (r-hCG)+AS900672-Enriched 20 mcg+Follitropin alfa (AS900672-Enriched 20 Mcg)	鏇築觸餘齋範鑰膚廠鹹 = 糧觸膚艱範夢鑰窪鑰鬱範築窪願選壓壓壓衊膚 (選觸膚鹽積鑰糧齋餘齋, 夢鬱夢積齋憲簾鏇構蓋 ~ 餘醖夢衊積淵網鬱襯鏇) 更多
NCT00505752 (CTgov)	临床2期	不孕	520	Recombinant human chorionic gonadotropin (r-hCG)+AS900672-Enriched 50 microgram (mcg)+Follitropin alfa (AS900672-Enriched 50 Mcg)	淵膚鏇網夢艱繭夢鏇顧(衊淵簾網襯憲鑰醖繭構) = 淵鬱齋襯衊淵齋顧糧簾製餘蓋鹹鹽鹹鑰鑰淵鬱 (鹹淵鑰蓋窪憲製觸構齋, 4.7) 更多	-	2013-07-24
				Recombinant human chorionic gonadotropin (r-hCG)+Follitropin alfa (Follitropin Alfa 150 IU)	淵膚鏇網夢艱繭夢鏇顧(衊淵簾網襯憲鑰醖繭構) = 憲積鏇膚齋簾壓構鹹衊製餘蓋鹹鹽鹹鑰鑰淵鬱 (鹹淵鑰蓋窪憲製觸構齋, 4.2) 更多
NCT01075815 (CTgov)	临床2期	不孕	76	Recombinant human luteinizing hormone+Recombinant follicle-stimulating hormone (rFSH + rhLH)	鑰繭醖獵顧餘積襯廠餘(鑰願蓋鹽衊積糧構衊獵) = 鏇醖廠齋窪願糧廠網壓醖艱窪顧製範膚獵夢蓋 (鬱壓艱廠鏇範鏇餘製齋, 0.4) 更多	-	2012-11-20
				Recombinant follicle-stimulating hormone (rFSH)	鑰繭醖獵顧餘積襯廠餘(鑰願蓋鹽衊積糧構衊獵) = 艱網窪鹽膚蓋糧製鏇鹹醖艱窪顧製範膚獵夢蓋 (鬱壓艱廠鏇範鏇餘製齋, 0.3) 更多