Obicetrapib

– Topline data from pivotal Phase 3 TANDEM trial now expected in 4Q 2024 due to faster than expected enrollment – – On-track to report topline data from pivotal Phase 3 BROADWAY trial in 4Q 2024 – – Strong balance sheet with $422.7 million in cash as of September 30, 2024 – NAARDEN, The Netherlands and MIAMI, Nov. 06, 2024 (GLOBE NEWSWIRE) -- NewAmsterdam Pharma Company N.V. (Nasdaq: NAMS or “NewAmsterdam” or the “Company”), a late-stage, clinical biopharmaceutical company developing oral, non-statin medicines for patients at risk of cardiovascular disease (“CVD”) with elevated low-density lipoprotein cholesterol (“LDL-C”), for whom existing therapies are not sufficiently effective or well-tolerated, today announced financial results for the three and nine months ended September 30, 2024. “We are pleased to report another strong quarter, which was marked by continued execution across our ongoing Phase 3 clinical trials. We are excited to announce that due to faster than expected enrollment in our pivotal Phase 3 TANDEM trial evaluating a fixed-dose combination (“FDC”) of obicetrapib and ezetimibe, we now expect to release topline data in the fourth quarter of 2024,” said Michael Davidson, M.D., Chief Executive Officer of NewAmsterdam. “Additionally, we remain on track to announce topline data from our Phase 3 BROADWAY study by year end and continue to advance our 9,500-patient PREVAIL cardiovascular outcomes trial.” “We believe there is a substantial opportunity to address the unmet needs across cardiovascular disease, one of the leading causes of mortality worldwide. With our recently secured composition of matter patent granting exclusivity through 2043 in the United States, cash which we believe is sufficient to fund our pivotal Phase 3 readouts, and an experienced leadership team at the helm, we are well-positioned to drive our mission forward. We remain focused on our clinical execution and, if approved, ultimately commercializing obicetrapib to transform patient care for the millions of people living with hyperlipidemia,” continued Dr. Davidson. Clinical Development Updates NewAmsterdam is developing obicetrapib, an oral, low-dose and once-daily cholesteryl ester transfer protein (“CETP”) inhibitor, as the preferred LDL-C lowering therapy to be used in patients at risk of CVD for whom existing therapies are not sufficiently effective or well-tolerated. Due to faster than expected patient enrollment in the pivotal Phase 3 TANDEM trial evaluating the obicetrapib and ezetimibe FDC, in patients with heterozygous familial hypercholesterolemia (“HeFH”) and/or atherosclerotic cardiovascular disease (“ASCVD”) or ASCVD risk equivalents, the Company expects to announce topline data in the fourth quarter of 2024. Upcoming Potential Milestones NewAmsterdam’s global, pivotal Phase 3 clinical development program consists of four studies in over 12,250 patients, three for obicetrapib monotherapy and one for a FDC of obicetrapib and ezetimibe. NewAmsterdam currently expects to achieve the following upcoming milestones: Announce additional safety and efficacy data from the Phase 3 BROOKLYN trial for obicetrapib monotherapy at the upcoming 2024 AHA Scientific Sessions taking place November 16 – 18 in Chicago, Illinois.Announce topline data from the Phase 3 BROADWAY trial for obicetrapib monotherapy in the fourth quarter of 2024. BROADWAY is evaluating obicetrapib in adult patients with HeFH and/or established ASCVD, whose LDL-C is not adequately controlled, despite being on maximally tolerated lipid-lowering therapy.Announce topline data from the Phase 3 TANDEM trial evaluating a FDC of obicetrapib and ezetimibe in the fourth quarter of 2024. Third Quarter Financial Results Cash Position: As of September 30, 2024, NewAmsterdam recorded cash of $422.7 million, compared to $340.5 million as of December 31, 2023. The increase in cash is primarily driven by the proceeds of the follow-on offering conducted earlier this year, the achievement of a clinical development milestone and warrant exercises partially offset by cash outflows related to research and development costs as the Company continues development of obicetrapib and increased spending on selling, general and administrative expenses to support the Company’s growing organization.Revenue: NewAmsterdam recognized $29.1 million in revenue for the three months ended September 30, 2024, compared to $2.9 million in the same period in 2023. This increase is primarily due to the achievement of a clinical development milestone from Menarini during the current period. Research and Development (“R&D”) Expenses: R&D expenses were $35.7 million for the three months ended September 30, 2024, compared to $43.4 million for the same period in 2023. This decrease was primarily due to a decrease in clinical expenses related to clinical trials which are completed or nearing completion.Selling, General and Administrative (“SG&A”) Expenses: SG&A expenses were $18.4 million in three months ended September 30, 2024, compared to $9.1 million for the same period in 2023. This increase was primarily due to an increase in personnel costs related to expansion of the team to support the growth of the organization and investments in capabilities to support the Company’s planned commercial launch of obicetrapib, if approved.Net loss: Net loss for the three months ended September 30, 2024 was $16.6 million compared to net loss of $47.1 million for the same period in 2023. The individual components of the change are described above. About Obicetrapib Obicetrapib is a novel, oral, low-dose CETP inhibitor that NewAmsterdam is developing to overcome the limitations of current LDL-lowering treatments. In each of the Company’s Phase 2 trials, ROSE2, TULIP, ROSE, and OCEAN, as well as the Company’s Phase 3 BROOKLYN trial, evaluating obicetrapib as monotherapy or combination therapy, the Company observed statistically significant LDL-lowering combined with a side effect profile similar to that of placebo. The Company is conducting an additional Phase 3 pivotal trial BROADWAY, to evaluate obicetrapib as a monotherapy used as an adjunct to maximally tolerated lipid-lowering therapies to provide additional LDL-lowering for CVD patients, and TANDEM, to evaluate obicetrapib and ezetimibe as a fixed-dose combination. The Company began enrolling patients in BROADWAY in January 2022 and in TANDEM in March 2024; completing enrollment of BROADWAY in July 2023, and TANDEM in July 2024. The Company also commenced the Phase 3 PREVAIL cardiovascular outcomes trial in March 2022, which is designed to assess the potential of obicetrapib to reduce occurrences of major adverse cardiovascular events, including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke and non-elective coronary revascularization. NewAmsterdam completed enrollment of PREVAIL in April 2024 and randomized over 9,500 patients. Commercialization rights of obicetrapib in Europe, either as a monotherapy or as part of a fixed dose combination with ezetimibe, for cardiovascular diseases have been exclusively granted to the Menarini Group, an Italy-based, leading international pharmaceutical and diagnostics company. About NewAmsterdam NewAmsterdam Pharma (Nasdaq: NAMS) is a late-stage biopharmaceutical company whose mission is to improve patient care in populations with metabolic diseases where currently approved therapies have not been adequate or well tolerated. We seek to fill a significant unmet need for a safe, well-tolerated and convenient LDL-lowering therapy. In multiple phase 3 studies, NewAmsterdam is investigating obicetrapib, an oral, low-dose and once-daily CETP inhibitor, alone or as a fixed-dose combination with ezetimibe, as LDL-C lowering therapies to be used as an adjunct to statin therapy for patients at risk of CVD with elevated LDL-C, for whom existing therapies are not sufficiently effective or well tolerated. Forward-Looking Statements Certain statements included in this document that are not historical facts are forward-looking statements for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements generally are accompanied by words such as “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “should,” “would,” “plan,” “predict,” “potential,” “seem,” “seek,” “future,” “outlook” and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements regarding the Company’s intellectual property and its ability to enforce, and sufficiency of, its patents, the Company’s business and strategic plans, the Company’s commercial opportunity, the therapeutic and curative potential of the Company’s product candidate, the Company’s clinical trials and the timing for enrolling patients, the timing and forums for announcing data, the achievement and timing of regulatory approvals, and plans for commercialization. These statements are based on various assumptions, whether or not identified in this document, and on the current expectations of the Company’s management and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as and must not be relied on as a guarantee, an assurance, a prediction, or a definitive statement of fact or probability. Actual events and circumstances are difficult or impossible to predict and may differ from assumptions. Many actual events and circumstances are beyond the control of the Company. These forward-looking statements are subject to a number of risks and uncertainties, including changes in domestic and foreign business, market, financial, political, and legal conditions; risks related to the approval of the Company’s product candidate and the timing of expected regulatory and business milestones, including potential commercialization; ability to negotiate definitive contractual arrangements with potential customers; the impact of competitive product candidates; ability to obtain sufficient supply of materials; global economic and political conditions, including the Russia-Ukraine and Israel-Hamas conflict; the effects of competition on the Company’s future business; and those factors described in the Company’s public filings with the Securities Exchange Commission. Additional risks related to the Company’s business include, but are not limited to: uncertainty regarding outcomes of the Company’s ongoing clinical trials, particularly as they relate to regulatory review and potential approval for its product candidate; risks associated with the Company’s efforts to commercialize a product candidate; the Company’s ability to negotiate and enter into definitive agreements on favorable terms, if at all; the impact of competing product candidates on the Company’s business; intellectual property related claims; the Company’s ability to attract and retain qualified personnel; ability to continue to source the raw materials for its product candidate. If any of these risks materialize or the Company’s assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. There may be additional risks that the Company does not presently know or that the Company currently believes are immaterial that could also cause actual results to differ from those contained in the forward-looking statements. In addition, forward-looking statements reflect the Company’s expectations, plans, or forecasts of future events and views as of the date of this document and are qualified in their entirety by reference to the cautionary statements herein. The Company anticipates that subsequent events and developments may cause the Company’s assessments to change. These forward-looking statements should not be relied upon as representing the Company’s assessment as of any date subsequent to the date of this communication. Accordingly, undue reliance should not be placed upon the forward-looking statements. Neither the Company nor any of its affiliates undertakes any obligation to update these forward-looking statements, except as may be required by law. Company ContactMatthew PhilippeP: 1-917-882-7512matthew.philippe@newamsterdampharma.com Media ContactSpectrum Science on behalf of NewAmsterdamBryan BlatsteinP: 1-917-714-2609bblatstein@spectrumscience.com Investor ContactPrecision AQ on behalf of NewAmsterdamAustin MurtaghP: 1-212-698-8696austin.murtagh@precisionaq.com Financial Tables NewAmsterdam Pharma Company N.V.Condensed Consolidated Balance Sheets(Unaudited) September 30, 2024 December 31, 2023 (In thousands of USD) Assets Current assets: Cash422,729 340,450 Prepayments and other receivables15,145 6,341 Total current assets437,874 346,791 Property, plant and equipment, net231 46 Operating right of use asset493 55 Intangible assets593 170 Long term prepaid expenses- 35 Total assets439,191 347,097 Liabilities and Shareholders' Equity Current liabilities: Accounts payable7,039 16,923 Accrued expenses and other current liabilities10,580 11,398 Deferred revenue, current4,495 8,942 Lease liability, current240 60 Derivative warrant liabilities18,901 12,574 Total current liabilities41,255 49,897 Deferred revenue, net of current portion- 1,019 Lease liability, net of current portion266 - Derivative earnout liability18,808 7,788 Total liabilities60,329 58,704 Commitments and contingencies (Note 10) Shareholders' Equity (deficit): Ordinary shares, €0.12 par value; 400,000,000 shares authorized; 92,165,605 and 82,469,768 shares issued and outstanding as at September 30, 2024 and December 31, 2023, respectively11,435 10,173 Additional paid-in capital829,399 590,771 Accumulated loss(466,394) (316,973)Accumulated other comprehensive income4,422 4,422 Total shareholders' equity378,862 288,393 Total liabilities and shareholders' equity439,191 347,097 NewAmsterdam Pharma Company N.V.Condensed Consolidated Statements of Operations and Comprehensive Income (Loss)(Unaudited) For the three months ended September 30, For the nine months ended September 30, 2024 2023 2024 2023 (In thousands of USD, except share and per share amounts) Revenue 29,111 2,941 32,791 13,287 Operating expenses: Research and development expenses 35,702 43,371 116,511 118,132 Selling, general and administrative expenses 18,412 9,128 49,340 27,048 Total operating expenses 54,114 52,499 165,851 145,180 Operating loss (25,003) (49,558) (133,060) (131,893)Other income (expense): Interest income 4,443 3,059 12,396 8,615 Fair value change – earnout and warrants (770) 2,521 (30,028) (4,004)Foreign exchange gains/(losses) 4,682 (3,155) 1,270 (160)Loss before tax (16,648) (47,133) (149,422) (127,442)Income tax expense (1) — (1) — Loss and comprehensive loss for the period (16,647) (47,133) (149,421) (127,442)Net loss per ordinary share: Basic and diluted net loss per ordinary share$(0.18) $(0.57) $(1.61) $(1.55)Basic and diluted weighted average number of ordinary shares outstanding 94,754,140 82,466,584 92,666,874 82,058,225 NewAmsterdam Pharma Company N.V.Condensed Consolidated Statements of Shareholders' Equity (Deficit)(Unaudited) (In thousands of USD, except share amounts)Shares Amount Additional Paid-In Capital Accumulated Loss Cumulative Translation Adjustments Total Shareholders' Equity Balance at December 31, 202281,559,780 10,055 555,625 (140,036) 4,422 430,066 Exercise of warrants208,032 27 2,671 — — 2,698 Share-based compensation— — 7,663 — — 7,663 Total loss and comprehensive loss for the period— — — (42,018) — (42,018)As at March 31, 202381,767,812 10,082 565,959 (182,054) 4,422 398,409 Exercise of warrants541,609 70 7,444 — — 7,514 Exercise of stock options14,910 2 103 — — 105 Share-based compensation— — 5,606 — — 5,606 Total loss and comprehensive loss for the period— — — (38,291) — (38,291)As at June 30, 202382,324,331 10,154 579,112 (220,345) 4,422 373,343 Exercise of warrants100 0 1 — — 1 Exercise of stock options145,337 19 166 — — 185 Share-based compensation— — 5,439 — — 5,439 Total loss and comprehensive loss for the period— — — (47,133) — (47,133)As at September 30, 202382,469,768 10,173 584,718 (267,478) 4,422 331,835 Balance at December 31, 202382,469,768 10,173 590,771 (316,973) 4,422 288,393 Issuance of Ordinary Shares and Pre-Funded Warrants, net of issuance costs5,871,909 759 189,207 — — 189,966 Exercise of warrants926,698 121 19,674 — — 19,795 Exercise of stock options452,461 60 (609) — — (549)Share-based compensation— — 7,965 — — 7,965 Total loss and comprehensive loss for the period— — — (93,767) — (93,767)As at March 31, 202489,720,836 11,113 807,008 (410,740) 4,422 411,803 Exercise of warrants294,521 38 6,268 — — 6,306 Share-based compensation— — 8,337 — — 8,337 Total loss and comprehensive loss for the period— — — (39,007) — (39,007)As at June 30, 202490,015,357 11,151 821,613 (449,747) 4,422 387,439 Exercise of Pre-Funded Warrants2,105,248 279 (279) — — — Exercise of stock options45,000 5 53 — — 58 Share-based compensation— — 8,012 — — 8,012 Total loss and comprehensive loss for the period— — — (16,647) — (16,647)As at September 30, 202492,165,605 11,435 829,399 (466,394) 4,422 378,862 NewAmsterdam Pharma Company N.V.Condensed Consolidated Statements of Cash Flows(Unaudited) For the nine months ended September 30, 2024 2023 (In thousands of USD) Operating activities: Loss for the period(149,421) (127,442)Non-cash adjustments to reconcile loss before tax to net cash flows: Depreciation and amortization62 36 Non-cash rent expense8 5 Fair value change - derivative earnout and warrants30,028 4,004 Foreign exchange (gains)/losses(1,270) 160 Share-based compensation24,204 18,566 Changes in working capital: Changes in prepayments (current and non-current) and other receivables(8,769) 988 Changes in accounts payable(9,751) (7,824)Changes in accrued expenses and other current liabilities(708) 11,266 Changes in deferred revenue(5,466) (7,903)Net cash (used in)/provided by operating activities(121,083) (108,144)Investing activities: Purchase of property, plant and equipment, including internal use software(669) (21)Net cash used in investing activities(669) (21)Financing activities: Proceeds from offering of Ordinary Shares and Pre-Funded Warrants190,481 — Transaction costs on issue of Ordinary Shares and Pre-Funded Warrants(515) — Proceeds from exercise of warrants13,421 8,622 Proceeds from exercise of options498 290 Payment of withholding taxes related to net share settlement of exercised options(989) — Net cash provided by financing activities202,896 8,912 Net change in cash81,144 (99,253)Foreign exchange differences1,135 (168)Cash at the beginning of the period340,450 467,728 Cash at the end of the period422,729 368,307 Noncash financing and investing activities Right-of-use assets obtained in exchange for new operating lease liabilities562 —

NAARDEN, The Netherlands and MIAMI, Oct. 28, 2024 (GLOBE NEWSWIRE) -- NewAmsterdam Pharma Company N.V. (Nasdaq: NAMS or “NewAmsterdam” or the “Company”), a late-stage, clinical biopharmaceutical company developing oral, non-statin medicines for patients at risk of cardiovascular disease (“CVD”) with elevated low-density lipoprotein cholesterol (“LDL-C”), for whom existing therapies are not sufficiently effective or well-tolerated, today announced that it will present additional safety and efficacy data from the pivotal Phase 3 BROOKLYN study evaluating obicetrapib in patients with Heterozygous Familial Hypercholesterolemia in a late-breaking oral presentation at the 2024 American Heart Association (AHA) Scientific Sessions, taking place November 16 – 18, 2024 in Chicago, Illinois. Additionally, NewAmsterdam announced that company management will participate in the Jefferies London Healthcare Conference, taking place November 19 – 21, 2024 in London. Details are as follows: 2024 AHA Scientific Sessions Presentation Title: Safety and Efficacy of Obicetrapib in Patients with Heterozygous Familial Hypercholesterolemia (BROOKLYN)Session Title: Late-Breaking Science 8: New Targets and New Treatments: Advances in Lipid TherapeuticsPresentation Date and Time: Monday, November 18, 2024, 2:14 p.m. – 2:26 p.m. CST (3:14 p.m. – 3:26 p.m. ET)Presenter: Stephen Nicholls, M.B.B.S., Ph.D., Director, Monash Victorian Heart Institute and Professor of Cardiology, Monash University Jefferies London Healthcare Conference Fireside Chat Date and Time: Thursday, November 21, 2024, at 1:00pm GMTPresenters: Michael Davidson, M.D., Chief Executive Officer, NewAmsterdam Pharma, John Kastelein, M.D., Ph.D., FESC, Chief Scientific Officer, Ian Somaiya, Chief Financial Officer A live webcast of the Jefferies fireside chat will be available through the investor relations section of the NewAmsterdam Pharma website at ir.newamsterdampharma.com. Following the live webcast, an archived replay will be available on the Company’s website. About Obicetrapib Obicetrapib is a novel, oral, low-dose CETP inhibitor that NewAmsterdam is developing to overcome the limitations of current LDL-lowering treatments. In each of the Company’s Phase 2 trials, ROSE2, TULIP, ROSE, and OCEAN, as well as the Company’s Phase 3 BROOKLYN trial, evaluating obicetrapib as monotherapy or combination therapy, the Company observed statistically significant LDL-lowering combined with a side effect profile similar to that of placebo. The Company is conducting an additional Phase 3 pivotal trial BROADWAY, to evaluate obicetrapib as a monotherapy used as an adjunct to maximally tolerated lipid-lowering therapies to provide additional LDL-lowering for CVD patients, and TANDEM, to evaluate obicetrapib and ezetimibe as a fixed-dose combination. The Company began enrolling patients in BROADWAY in January 2022 and in TANDEM in March 2024; completing enrollment of BROADWAY in July 2023, and TANDEM in July 2024. The Company also commenced the Phase 3 PREVAIL cardiovascular outcomes trial in March 2022, which is designed to assess the potential of obicetrapib to reduce occurrences of major adverse cardiovascular events, including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke and non-elective coronary revascularization. NewAmsterdam completed enrollment of PREVAIL in April 2024 and randomized over 9,500 patients. Commercialization rights of obicetrapib in Europe, either as a monotherapy or as part of a fixed dose combination with ezetimibe, for cardiovascular diseases have been exclusively granted to the Menarini Group, an Italy-based, leading international pharmaceutical and diagnostics company. About NewAmsterdam NewAmsterdam Pharma (Nasdaq: NAMS) is a late-stage biopharmaceutical company whose mission is to improve patient care in populations with metabolic diseases where currently approved therapies have not been adequate or well tolerated. We seek to fill a significant unmet need for a safe, well-tolerated and convenient LDL-lowering therapy. In multiple phase 3 studies, NewAmsterdam is investigating obicetrapib, an oral, low-dose and once-daily CETP inhibitor, alone or as a fixed-dose combination with ezetimibe, as LDL-C lowering therapies to be used as an adjunct to statin therapy for patients at risk of CVD with elevated LDL-C, for whom existing therapies are not sufficiently effective or well tolerated. Company Contact Matthew PhilippeP: 1-917-882-7512matthew.philippe@newamsterdampharma.com Media Contact Spectrum Science on behalf of NewAmsterdamBryan BlatsteinP: 1-917-714-2609bblatstein@spectrumscience.com Investor Contact Precision AQ on behalf of NewAmsterdamAustin MurtaghP: 1-212-698-8696austin.murtagh@precisionaq.com