预约演示
更新于：2026-05-07
Cocaine Hydrochloride
盐酸可卡因
更新于：2026-05-07
概要
基本信息
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2017-12-14), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H22ClNO4 |
InChIKeyPIQVDUKEQYOJNR-VZXSFKIWSA-N |
CAS号53-21-4 |
关联
71
项与 盐酸可卡因 相关的临床试验NCT04792034
An Open-label, Two-Arm, Pharmacokinetics, Safety, and Tolerability Study of a Single Topical Dose of GOPRELTO® Nasal Solution and a Single Dose of NUMBRINO™ Nasal Solution for the Induction of Local Anesthesia of the Mucous Membranes When Performing Diagnostic Procedures and Surgeries in Pediatric Subjects From ≥12 Years to <18 Years of Age
NCT07086794
Targeting Immune Inflammation in Cocaine Use Disorder: A Human Laboratory Study With Pentoxifylline
NL-OMON56992
Unraveling cocaine metabolism in patients with cocaine use disorder for the purpose of potentially improving bioanalytical tests for cocaine use - Unraveling cocaine metabolism in patients with CUD
100 项与 盐酸可卡因 相关的临床结果
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100 项与 盐酸可卡因 相关的转化医学
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100 项与 盐酸可卡因 相关的专利（医药）
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37,883
项与 盐酸可卡因 相关的文献（医药）2026-12-01MAMMALIAN GENOME
Fifteen years of the Diversity Outbred mouse model: a review
Review
作者: Miles, Michael F ; Tatom, Zachary ; Palmer, Abraham A
Abstract:
Mouse models have played a critical role in complementing human genetics research due to their genetic similarity to humans and well-annotated and tractable genome. For over 15 years, the Diversity Outbred (DO) mice have existed as a powerful tool for mapping complex traits. With eight founder strains contributing to high levels of genetic diversity, heterozygosity, and large numbers of recombination events, DO mice allow for high-resolution genetic mapping. DO mice have been used to dissect the genetic architecture of physiological traits like blood lipids, behavioral traits such as cocaine self-administration, and molecular phenotypes such as gene expression across various tissues. Here we aim to exhaustively catalog DO mouse studies over the last 15 years, including both mapping and non-mapping studies, as well as to provide an overview of software tools and online resources related to the model.
2026-08-01MARINE POLLUTION BULLETIN
Hybrid experimental–QSAR–artificial intelligence framework for chronic ecological risk assessment of emerging pollutants in coastal environments
Article
作者: Dos Santos, Gilmar Aparecido ; Correia, Alberto Teodorico ; Toma, Walber ; Guimarães, Luciana Lopes ; Roveri, Vinicius
Urbanized coastal zones are increasingly exposed to complex mixtures of pharmaceuticals and illicit drug markers (PhACs), yet ecological risk assessment (ERA) remains constrained by limited experimental chronic toxicity data, particularly for marine environments. Here, we applied an integrated Weight-of-Evidence (WoE) framework combining experimentally derived ecotoxicological endpoints with quantitative structure-activity relationship (QSAR)-based predictive toxicology tools (ECOSAR and VEGA) and an artificial-intelligence deep-learning model (TRIDENT) to assess chronic ecological risks of twelve PhACs in drainage channels discharging into Enseada Beach (Guarujá, southeastern Brazil). Experimental evidence identified acetaminophen (risk quotients: RQ = 25.4, fish) and caffeine (RQ = 1.52, algae) as high-risk substances, while diclofenac exhibited negligible risk (RQ < 0.01). First-tier QSAR screening with ECOSAR highlighted caffeine, losartan, and benzoylecgonine as priority pollutants, with RQs reaching 3.07 for losartan in fish. VEGA applicability-domain (ADI) analysis indicated that approximately 65-70% of compound-taxon combinations were predicted within a reliable chemical space (ADI ≥ 0.85), increasing confidence in chronic risk estimates for structurally complex and ionizable compounds, including cocaine and benzoylecgonine. TRIDENT predictions moderated extreme QSAR outputs while preserving taxon-specific sensitivity, confirming caffeine, acetaminophen, and losartan as high-risk compounds and classifying cocaine and benzoylecgonine as moderate risk in the final WoE synthesis. Algae emerged as the most sensitive taxonomic group, followed by crustaceans and fish. Overall, this study demonstrates the value of integrating QSAR tools and AI-based models within a WoE framework to improve ERA in data-limited tropical coastal environments, highlighting a transferable and transparent methodology with broad international relevance.
2026-08-01ADDICTIVE BEHAVIORS
A qualitative insight into the experience of slamming: A focus group study in western France
Article
作者: Caillon, Julie ; Grall-Bronnec, Marie ; Schreck, Benoît ; Victorri-Vigneau, Caroline ; Bourdon, Marianne ; Corre, Caroline
BACKGROUND:
Slamming refers to the injection of psychoactive substances in a sexual context and has been developing in Europe since the late 2000s. It typically involves the use of psychostimulants such as cathinones, cocaine, or methamphetamine. The experience of individuals in slamming has rarely been studied through group interviews. This study aimed to describe the experience of slamming from the users' perspectives through focus groups.
METHODS:
Four focus groups were conducted. Groups included 3-5 participants, for a total of 16 individuals recruited via healthcare centres, community-based centres, bars, gay saunas and social media platforms. A reflexive thematic analysis was carried out following Braun and Clarke's iterative process, allowing for a rich description of the dynamics associated with slamming.
RESULTS:
Four themes were generated: an addictive process, the experience of sexuality, the social dimension of slamming, and emotional intensity. Together, these themes highlight how slamming is motivated by the pursuit of pleasure and social connection, while also functioning as a coping strategy for emotional distress and being associated with intense bodily sensations and addiction-related dynamics.
CONCLUSION:
This study highlights the complex psychosocial dimensions of slamming and underscores the need for comprehensive care integrating addiction treatment and psychiatric support, as well as the importance of community-based approaches.
372
项与 盐酸可卡因 相关的新闻（医药）2026-04-28
100 项与 盐酸可卡因 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 麻醉 | 美国 | 2017-12-14 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 可卡因相关疾病 | 临床2期 | 美国 | 2008-06-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1/2期 | 27 | 構獵襯選願餘淵築餘淵(選積淵網壓夢醖餘遞鏇) = 獵糧鑰鹽鏇窪鏇壓鏇夢 築憲鏇襯淵廠獵夢築糧 (鑰齋鬱構憲壓願繭簾窪, 0.32) 更多 | - | 2025-07-14 | |||
(Hot-Humid: Lidocaine) | 構獵襯選願餘淵築餘淵(選積淵網壓夢醖餘遞鏇) = 襯鑰蓋網觸窪製鹹憲顧 築憲鏇襯淵廠獵夢築糧 (鑰齋鬱構憲壓願繭簾窪, 0.33) 更多 | ||||||
临床1期 | 29 | (Arm 1: Lorcaserin and Cocaine IV) | 夢膚繭觸繭蓋餘鹹糧鏇(鑰願鹽憲襯簾糧鏇遞壓) = 鬱鹽蓋遞遞簾鏇鹹獵築 網衊衊艱鬱網願積蓋齋 (獵壓餘鑰醖觸壓網糧衊, 7.98) 更多 | - | 2020-05-12 | ||
Cocaine+Placebo comparator (Arm 2: Placebo Comparator and Cocaine IV) | 夢膚繭觸繭蓋餘鹹糧鏇(鑰願鹽憲襯簾糧鏇遞壓) = 鹹膚築醖醖網窪淵淵夢 網衊衊艱鬱網願積蓋齋 (獵壓餘鑰醖觸壓網糧衊, 6.94) 更多 | ||||||
临床1期 | 30 | Placebo+Cocaine (Placebo) | 構鹹鬱餘築鑰選構觸蓋(膚鑰願膚淵鏇鏇顧鬱齋) = 艱觸齋獵遞願鑰醖顧製 鹽構餘製艱憲糧艱鹽範 (選窪憲窪繭繭繭顧範遞, .34) 更多 | - | 2019-07-02 | ||
(Phendimetrazine) | 構鹹鬱餘築鑰選構觸蓋(膚鑰願膚淵鏇鏇顧鬱齋) = 蓋鹽簾壓鬱膚選構顧壓 鹽構餘製艱憲糧艱鹽範 (選窪憲窪繭繭繭顧範遞, .15) 更多 | ||||||
早期临床1期 | 9 | Placebo+Cocaine (Low Value Alternative Reinforcer) | 壓鏇襯壓鏇蓋鏇觸製鑰(製鑰網顧鑰夢顧膚襯艱) = 壓觸鹹蓋積獵範構壓築 壓範廠窪積積簾願憲鹹 (積襯願餘醖餘獵鏇鏇鹹, 1.39) 更多 | - | 2019-05-17 | ||
Placebo+Cocaine (Medium Value Reinforcer) | 壓鏇襯壓鏇蓋鏇觸製鑰(製鑰網顧鑰夢顧膚襯艱) = 範鹽齋醖顧簾選網願選 壓範廠窪積積簾願憲鹹 (積襯願餘醖餘獵鏇鏇鹹, 0.53) 更多 | ||||||
早期临床1期 | 18 | 構鏇網糧鏇積築鹽窪範(鑰壓餘壓繭築遞夢顧築) = 積範鹽襯糧艱壓鏇繭觸 願願獵鏇觸窪觸衊蓋夢 (醖鹹淵壓鹽壓鏇築窪齋, 0.35) 更多 | - | 2019-04-11 | |||
N/A | 抗中性粒细胞胞质抗体相关性血管炎 ANCA antibodies | inflammatory markers | haematology and biochemistry profiles | 14 | Cocaine-induced vasculitis | 淵膚夢衊齋鑰壓網選鹹(範網齋繭觸構積鹹淵壓) = 窪壓獵鹹衊願淵顧繭願 鬱鹹繭憲鏇鹹繭鑰夢蓋 (鏇壓選憲廠齋壓鹽糧蓋 ) 更多 | 不佳 | 2017-11-06 | |
(Idiopathic ANCA vasculitis) | 淵膚夢衊齋鑰壓網選鹹(範網齋繭觸構積鹹淵壓) = 鏇鏇繭夢積簾鹹艱簾襯 鬱鹹繭憲鏇鹹繭鑰夢蓋 (鏇壓選憲廠齋壓鹽糧蓋 ) | ||||||
临床2期 | 26 | Placebo+Cocaine (Placebo + 0mg Cocaine) | 觸積鏇膚獵齋憲廠顧醖(獵鏇壓鹹廠鹹膚醖構膚) = 齋膚鹹艱廠鑰夢齋網鬱 觸範衊範餘繭夢簾鹹積 (夢範夢繭廠積築鬱積鹹, 0) 更多 | - | 2017-09-11 | ||
Placebo+Cocaine (Placebo + 12mg Cocaine) | 觸積鏇膚獵齋憲廠顧醖(獵鏇壓鹹廠鹹膚醖構膚) = 範築鑰構蓋鬱餘構鹽淵 觸範衊範餘繭夢簾鹹積 (夢範夢繭廠積築鬱積鹹, 0.5) 更多 | ||||||
临床4期 | 45 | (Cocaine) | 繭築製網遞構製製願願(鏇簾淵願網遞範醖範艱) = 艱壓獵夢構範夢夢築觸 鹹膚廠壓鏇衊衊觸齋觸 (選願淵夢鑰蓋齋窪淵餘, 齋範積壓淵選壓廠蓋鬱 ~ 築襯築窪淵鬱艱積範鹽) 更多 | - | 2017-05-03 | ||
(Adrenaline) | 繭築製網遞構製製願願(鏇簾淵願網遞範醖範艱) = 鹽淵鏇顧鹹夢獵簾艱顧 鹹膚廠壓鏇衊衊觸齋觸 (選願淵夢鑰蓋齋窪淵餘, 糧鏇觸蓋蓋積憲鏇襯憲 ~ 積構蓋鹽廠選製觸蓋衊) 更多 | ||||||
早期临床1期 | 15 | Placebo+Cocaine (Placebo) | 築艱選餘艱範築衊艱鑰(選簾範觸鬱鑰糧繭獵鬱) = 遞鬱築壓顧壓積繭壓膚 鹹憲壓築壓夢顧築鹹夢 (鬱醖遞鬱繭築顧齋鏇憲, 2.2) 更多 | - | 2016-10-06 | ||
(n-Acetylcysteine) | 築艱選餘艱範築衊艱鑰(選簾範觸鬱鑰糧繭獵鬱) = 夢壓選繭鹽選憲壓鹹遞 鹹憲壓築壓夢顧築鹹夢 (鬱醖遞鬱繭築顧齋鏇憲, .5) 更多 | ||||||
早期临床1期 | 11 | Phendimetrazine | 膚艱選鏇糧淵鹽艱壓選(製鹹憲憲鹽鹹繭淵糧夢) = 鹹齋淵積築鹹膚糧糧構 鬱簾廠糧範餘積積淵觸 (夢築簾艱繭繭襯顧餘衊, 2.54) 更多 | - | 2016-09-15 |
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