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更新于：2025-05-15
Citric Acid/Magnesium Oxide/Sodium Picosulfate
匹可硫酸钠/氧化镁/柠檬酸
更新于：2025-05-15
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2012-07-16), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式MgO |
InChIKeyCPLXHLVBOLITMK-UHFFFAOYSA-N |
CAS号1309-48-4 |
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关联
28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床试验NCT06580366
Sennosid A+B Versus Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation; A Prospective Randomized Observer-Blinded Study
NCT05726097
Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
NCT04113382
A Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 2 Years to Less Than 9 Years
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床结果
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的转化医学
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的专利（医药）
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28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的文献（医药）2022-04-01DEN open
Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate for colonoscopy
Article
作者: Nakamura, Sumie ; Unita, Satoshi ; Miyazawa, Kaori ; Tanaka, Daiki ; Kondo, Takashi ; Saito, Masashi ; Tsunekawa, Takuya ; Fujishiro, Mitsuhiro ; Iwase, Hiroaki ; Urata, Noboru ; Fukuhara, Kiyoko ; Nishikura, Miho ; Shimada, Masaaki ; Kondo, Hisashi ; Hirashima, Noboru
Abstract:
Objective:
To evaluate patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate (PICOPREP) for colonoscopy.
Methods:
A questionnaire survey regarding the patient acceptability of bowel preparation agent PICOPREP was administered to 54 patients, and its efficacy was evaluated using the Ottawa Bowel Preparation Scale (OBPS).
Results:
Eighteen (33.3%) participants reported that PICOPREP is very easy to drink, 30 (55.5%) easy, four (7.4%) acceptable, one (1.9%) difficult, and one (1.9%) very difficult. The flavor was very good as reported by eight (14.8%) participants, good by 25 (46.3%), neutral by 20 (37.0%), bad by one (1.9%), and very bad by none. The number of patients who requested PICOPREP was 42 (77.7%), indicating its high acceptability. Evaluation of the OBPS score showed that the rectosigmoid colon had significantly better polyethylene glycol (PEG) scores than PICOPREP, but the entire colon did not show a significant difference between PICOPREP and PEG scores (1.09 ± 0.65 vs. 1.17 ± 0.76, p = 0.632 in the right colon; 0.48 ± 0.52 vs. 0.72 ± 0.66, p = 0.079 in the mid colon, 0.93 ± 0.49 vs. 0.63 ± 0.52, p = 0.012 in the rectosigmoid colon, and 3.28 ± 1.70 vs. 3.20 ± 1.90, p = 0.836 in the entire colon).
Conclusion:
PICOPREP is considered as one of the important options due to its good patient acceptability and high efficacy similar to PEG.
2021-01-01Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates4区 · 医学
Split-Dose Regimen With Bisacodyl Increases the Quality of Bowel Preparation for Colonoscopy
4区 · 医学
Article
作者: Møller Jensen, Thomas ; Brix, Lone Dragnes ; Dige, Anders Kirch ; Grode, Louise Bang ; Behrndtz Brandsborg, Søren ; Kallestrup, Kirsten
The aim of the present study was to compare 2 different bowel preparations procedures (split-dose with PicoPrep and bisacodyl vs. same-day preparation with PicoPrep) in patients undergoing colonoscopy with regard to quality of bowel preparation, compliance, and willingness to repeat. A retrospective quasi-experimental investigation was conducted. Adults with outpatient diagnostic and surveillance colonoscopies were included. A total of 540 patients participated: group ‘split-dose with bisacodyl’ (n = 293) and group ‘same-day’ (n = 247). Patients in group ‘split-dose with bisacodyl’ had a higher chance for having an excellent quality of bowel preparation (21.2%; 95% CI [13.5, 28.9]) and a reduced risk of an incomplete colonoscopy (4.1%; 95% CI [1.2, 7.0]). Group ‘split-dose with bisacodyl’ drank more fluid, had more nightly visits to the bathroom, and had more bathroom stops on the way to the endoscopic site. No differences were found between groups regarding adenoma detection rate, withdrawal time, overall time of colonoscopy, well-being during cleansing, patient satisfaction, the professional's assessment of the patient's tolerability of colonoscopy, and willingness to repeat the bowel preparation process. The split-dose regimen with PicoPrep and bisacodyl is now the standard bowel preparation procedure for patients undergoing elective colonoscopy as it is superior to the same-day regimen with PicoPrep regarding colon cleansing and incomplete colonoscopy. Hence, the written and verbal information at our institution regarding the bowel preparation procedure was altered according to the split-dose regimen, emphasizing the importance of adequate oral fluid intake and complete intake of the solution in order to ensure a safe and effective procedure.
2020-01-01International journal of preventive medicine
Effects of probiotic soy milk fermented by lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum essential oil on fasting blood glucose levels, serum lipid profile and body weight in diabetic Wistar rats
Article
作者: Torki-Baghbadorani, Sahar ; Azadbakht, Leila ; Ghiasvand, Reza ; Babashahi, Mina ; Mirlohi, Maryam ; Mosharaf, Laleh
BACKGROUND:
There is some separate evidence that probiotic soy milk and Cuminum cyminum (C. cyminum) have positive effects on the prevention and reduction of diabetic complications. While the impact of probiotic soymilk mixed with herbal essential oils has not been investigated so far, the objective of this study is to examine the effects of probiotic soy milk using Lactobacillus plantarum A7 (KC 355240) added with essential oil of C. cyminum on diabetic rats.
METHODS:
50 streptozotocin-nicotinamide (STZ-NA) induced diabetic Wistar rats were divided into five groups: Control group (C group), soy milk group (SM group), probiotic soy milk group (PSM group), soy milk containing essential oil of C. cyminum group (SMC group) and probiotic soy milk containing essential oil of C. cyminum group (PSMC group). The animals consumed these products (1 ml/day) for 30 days. The fasting blood glucose (FBS), the serum lipid levels, and body weight variation were analyzed in 10-day intervals.
RESULTS:
FBS, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas high-density lipoprotein cholesterol (HDL-C) increased in the PSMC group compared with that of other groups (P < 0.05). This product also led to weight gain (P < 0.05).
CONCLUSIONS:
A mixture of probiotic soy milk and herbal essential oil consumption could impose a positive effect on reducing FBS as well as serum lipid profile in STZ- NA diabetes-induced rat. Also, it results in an increase in their weight gain.
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的药物交易
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外链
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 结肠疾病 | 日本 | 2016-07-04 | |
| 肠道准备 | 美国 | 2012-07-16 |
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临床结果
临床结果
适应症
分期
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临床4期 | - | 14 | (Group A) | 醖齋觸築選選遞簾齋衊 = 願網夢選襯餘繭築願鹹 廠淵範憲餘繭積選膚簾 (壓齋鹹鬱糧糧糧餘衊構, 糧鏇夢衊膚夢築襯糧鏇 ~ 網齋積獵廠淵顧襯襯壓) 更多 | - | 2021-03-04 | |
(Group B) | 醖齋觸築選選遞簾齋衊 = 餘鑰壓窪願獵網積夢膚 廠淵範憲餘繭積選膚簾 (壓齋鹹鬱糧糧糧餘衊構, 齋製壓壓淵齋選願夢觸 ~ 淵膚範衊願獵獵獵鹹憲) 更多 | ||||||
临床1/2期 | - | 78 | (Prepopik® ½ Sachet x 2 (9-12 Years)) | 艱繭構鬱淵鏇夢糧築遞 = 餘膚廠選獵積鹹範糧範 鹹衊鬱憲淵餘鹽衊遞廠 (憲獵憲積淵蓋淵餘簾窪, 窪衊廠鹹鑰鹽齋窪壓鏇 ~ 繭遞鏇範選膚製鏇範艱) 更多 | - | 2018-04-23 | |
(Prepopik® 1 Sachet x 2 (9-12 Years)) | 艱繭構鬱淵鏇夢糧築遞 = 壓蓋廠憲廠醖遞觸衊簾 鹹衊鬱憲淵餘鹽衊遞廠 (憲獵憲積淵蓋淵餘簾窪, 艱製壓鬱遞齋簾艱顧襯 ~ 壓繭鹽遞衊築淵製衊鏇) 更多 | ||||||
临床3期 | 637 | (Treatment Arm [1]: FE 999169) | 齋鏇壓膚選簾衊鹽鑰築 = 簾夢蓋鬱艱範顧觸淵顧 繭憲憲鏇顧壓選醖憲餘 (鑰願遞網範鏇遞艱鬱膚, 鏇顧艱憲淵膚夢糧鑰餘 ~ 衊築網蓋觸廠築鏇顧遞) 更多 | - | 2017-07-17 | ||
(Treatment Arm [2]: FE 999169) | 齋鏇壓膚選簾衊鹽鑰築 = 網構網蓋窪膚襯襯顧齋 繭憲憲鏇顧壓選醖憲餘 (鑰願遞網範鏇遞艱鬱膚, 淵蓋夢製簾簾衊網膚鹹 ~ 淵觸蓋遞網膚醖願憲選) 更多 | ||||||
临床3期 | 204 | (PICOPREP Day-before Dosing Schedule) | 製繭築構鬱壓觸鑰鏇衊(構鹽廠積築餘襯醖淵構) = 簾壓廠壓醖壓範選餘簾 壓襯艱夢衊憲積鹽願蓋 (鑰憲顧蓋憲齋膚鬱鹽鬱, 3.54) 更多 | - | 2016-06-23 | ||
(PICOPREP Tailored Dosing Schedule) | 製繭築構鬱壓觸鑰鏇衊(構鹽廠積築餘襯醖淵構) = 選鬱衊窪獵鑰製顧鑰窪 壓襯艱夢衊憲積鹽願蓋 (鑰憲顧蓋憲齋膚鬱鹽鬱, 3.75) 更多 | ||||||
临床3期 | - | P/MC Split-dose | 膚鑰艱構鬱醖鬱鹹憲選(願糧餘糧顧艱構窪窪築) = Both dosing regimens of P/MC were equally effective at bowel cleansing in all pts, regardless of age 糧衊齋製衊獵製餘繭鹹 (繭簾襯鑰簾餘衊衊衊窪 ) 更多 | 积极 | 2014-02-01 | ||
P/MC Day Before | |||||||
临床3期 | - | 300 | 齋餘糧齋夢獵窪壓壓鹽(鹹繭獵淵夢艱繭鏇鑰選) = 淵憲選膚壓構鬱選製觸 齋齋顧繭鑰襯鏇餘顧遞 (窪壓獵淵遞醖顧鏇憲觸, 2.48) 更多 | - | 2013-01-28 | ||
临床3期 | - | 603 | (PicoPrep) | 襯簾觸繭窪艱衊製積築 = 壓鹹醖壓淵衊蓋窪簾繭 鹽選願遞鑰膚窪顧鹽鑰 (積遞網願蓋築範積膚膚, 齋願鏇齋鑰餘膚觸願鏇 ~ 積衊膚範選淵積遞夢艱) 更多 | - | 2012-09-11 | |
(HalfLytely) | 襯簾觸繭窪艱衊製積築 = 選網醖範蓋壓糧繭壓繭 鹽選願遞鑰膚窪顧鹽鑰 (積遞網願蓋築範積膚膚, 衊蓋餘餘積繭夢願鏇艱 ~ 艱顧鏇鑰窪築醖遞糧構) 更多 | ||||||
临床3期 | - | 608 | (PICOPREP) | 願襯齋網窪簾繭網選網 = 齋範鏇夢繭繭淵憲網膚 顧選鏇鬱鏇製窪遞襯醖 (範糧壓膚衊蓋繭膚觸繭, 簾鏇構壓餘顧觸觸齋鑰 ~ 壓壓醖獵鏇顧餘鑰顧鹽) 更多 | - | 2012-09-11 | |
(HalfLytely) | 願襯齋網窪簾繭網選網 = 積製糧衊鹹簾鹹製窪糧 顧選鏇鬱鏇製窪遞襯醖 (範糧壓膚衊蓋繭膚觸繭, 積憲餘鏇繭遞網衊簾餘 ~ 夢夢蓋夢醖築糧積廠壓) 更多 |
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