更新于：2024-09-06
Citric Acid/Magnesium Oxide/Sodium Picosulfate
匹可硫酸钠/氧化镁/柠檬酸
更新于：2024-09-06
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2012-07-16), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构
分子式MgO |
InChIKeyCPLXHLVBOLITMK-UHFFFAOYSA-N |
CAS号1309-48-4 |
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关联
28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床试验Sennosid A+B Versus Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation; A Prospective Randomized Observer-Blinded Study
Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
A Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 2 Years to Less Than 9 Years
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床结果
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的转化医学
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的专利（医药）
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28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的文献（医药）2022-04-01DEN open
Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate for colonoscopy
Article
作者: Nakamura, Sumie ; Unita, Satoshi ; Miyazawa, Kaori ; Tanaka, Daiki ; Kondo, Takashi ; Saito, Masashi ; Tsunekawa, Takuya ; Fujishiro, Mitsuhiro ; Iwase, Hiroaki ; Urata, Noboru ; Fukuhara, Kiyoko ; Nishikura, Miho ; Shimada, Masaaki ; Kondo, Hisashi ; Hirashima, Noboru
Abstract:
Objective:
To evaluate patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate (PICOPREP) for colonoscopy.
Methods:
A questionnaire survey regarding the patient acceptability of bowel preparation agent PICOPREP was administered to 54 patients, and its efficacy was evaluated using the Ottawa Bowel Preparation Scale (OBPS).
Results:
Eighteen (33.3%) participants reported that PICOPREP is very easy to drink, 30 (55.5%) easy, four (7.4%) acceptable, one (1.9%) difficult, and one (1.9%) very difficult. The flavor was very good as reported by eight (14.8%) participants, good by 25 (46.3%), neutral by 20 (37.0%), bad by one (1.9%), and very bad by none. The number of patients who requested PICOPREP was 42 (77.7%), indicating its high acceptability. Evaluation of the OBPS score showed that the rectosigmoid colon had significantly better polyethylene glycol (PEG) scores than PICOPREP, but the entire colon did not show a significant difference between PICOPREP and PEG scores (1.09 ± 0.65 vs. 1.17 ± 0.76, p = 0.632 in the right colon; 0.48 ± 0.52 vs. 0.72 ± 0.66, p = 0.079 in the mid colon, 0.93 ± 0.49 vs. 0.63 ± 0.52, p = 0.012 in the rectosigmoid colon, and 3.28 ± 1.70 vs. 3.20 ± 1.90, p = 0.836 in the entire colon).
Conclusion:
PICOPREP is considered as one of the important options due to its good patient acceptability and high efficacy similar to PEG.
2021-01-01Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates4区 · 医学
Split-Dose Regimen With Bisacodyl Increases the Quality of Bowel Preparation for Colonoscopy
4区 · 医学
Article
作者: Møller Jensen, Thomas ; Brix, Lone Dragnes ; Dige, Anders Kirch ; Grode, Louise Bang ; Behrndtz Brandsborg, Søren ; Kallestrup, Kirsten
The aim of the present study was to compare 2 different bowel preparations procedures (split-dose with PicoPrep and bisacodyl vs. same-day preparation with PicoPrep) in patients undergoing colonoscopy with regard to quality of bowel preparation, compliance, and willingness to repeat. A retrospective quasi-experimental investigation was conducted. Adults with outpatient diagnostic and surveillance colonoscopies were included. A total of 540 patients participated: group ‘split-dose with bisacodyl’ (n = 293) and group ‘same-day’ (n = 247). Patients in group ‘split-dose with bisacodyl’ had a higher chance for having an excellent quality of bowel preparation (21.2%; 95% CI [13.5, 28.9]) and a reduced risk of an incomplete colonoscopy (4.1%; 95% CI [1.2, 7.0]). Group ‘split-dose with bisacodyl’ drank more fluid, had more nightly visits to the bathroom, and had more bathroom stops on the way to the endoscopic site. No differences were found between groups regarding adenoma detection rate, withdrawal time, overall time of colonoscopy, well-being during cleansing, patient satisfaction, the professional's assessment of the patient's tolerability of colonoscopy, and willingness to repeat the bowel preparation process. The split-dose regimen with PicoPrep and bisacodyl is now the standard bowel preparation procedure for patients undergoing elective colonoscopy as it is superior to the same-day regimen with PicoPrep regarding colon cleansing and incomplete colonoscopy. Hence, the written and verbal information at our institution regarding the bowel preparation procedure was altered according to the split-dose regimen, emphasizing the importance of adequate oral fluid intake and complete intake of the solution in order to ensure a safe and effective procedure.
2020-01-01International journal of preventive medicine
Effects of probiotic soy milk fermented by lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum essential oil on fasting blood glucose levels, serum lipid profile and body weight in diabetic Wistar rats
Article
作者: Torki-Baghbadorani, Sahar ; Azadbakht, Leila ; Ghiasvand, Reza ; Babashahi, Mina ; Mirlohi, Maryam ; Mosharaf, Laleh
BACKGROUND:
There is some separate evidence that probiotic soy milk and Cuminum cyminum (C. cyminum) have positive effects on the prevention and reduction of diabetic complications. While the impact of probiotic soymilk mixed with herbal essential oils has not been investigated so far, the objective of this study is to examine the effects of probiotic soy milk using Lactobacillus plantarum A7 (KC 355240) added with essential oil of C. cyminum on diabetic rats.
METHODS:
50 streptozotocin-nicotinamide (STZ-NA) induced diabetic Wistar rats were divided into five groups: Control group (C group), soy milk group (SM group), probiotic soy milk group (PSM group), soy milk containing essential oil of C. cyminum group (SMC group) and probiotic soy milk containing essential oil of C. cyminum group (PSMC group). The animals consumed these products (1 ml/day) for 30 days. The fasting blood glucose (FBS), the serum lipid levels, and body weight variation were analyzed in 10-day intervals.
RESULTS:
FBS, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas high-density lipoprotein cholesterol (HDL-C) increased in the PSMC group compared with that of other groups (P < 0.05). This product also led to weight gain (P < 0.05).
CONCLUSIONS:
A mixture of probiotic soy milk and herbal essential oil consumption could impose a positive effect on reducing FBS as well as serum lipid profile in STZ- NA diabetes-induced rat. Also, it results in an increase in their weight gain.
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 结肠疾病 | 日本 | 2016-07-04 | |
| 肠道准备 | 美国 | 2012-07-16 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | - | 14 | Golytely (Group A) | 襯夢鏇選壓簾構糧積餘(淵鑰鬱築淵築蓋衊鹽築) = 衊鹽廠鏇遞襯壓網簾獵 艱夢艱鑰糧鬱鏇艱鬱鬱 (蓋衊積憲繭鏇構遞衊淵, 簾鏇襯衊衊鏇窪願夢襯 ~ 積選糧艱觸蓋簾顧遞鹹) 更多 | - | 2021-03-04 | |
Golytely (Group B) | 襯夢鏇選壓簾構糧積餘(淵鑰鬱築淵築蓋衊鹽築) = 積窪鬱糧願選夢鹹獵艱 艱夢艱鑰糧鬱鏇艱鬱鬱 (蓋衊積憲繭鏇構遞衊淵, 遞範齋積憲鬱繭遞衊膚 ~ 齋餘窪顧艱憲餘觸窪餘) 更多 | ||||||
N/A | - | 32 | (Low Volume Prep (Prepopik)) | 顧觸窪顧夢窪製鹹簾遞(築餘選選鏇範糧簾艱壓) = 艱鹹築選窪蓋積築製簾 製築餘夢膚廠鏇鬱膚壓 (範範膚繭夢夢壓膚構醖, 窪蓋積觸鬱顧憲壓壓網 ~ 選壓獵餘製憲願壓鏇遞) 更多 | - | 2020-07-17 | |
(Moderate Volume Prep (Moviprep)) | 顧觸窪顧夢窪製鹹簾遞(築餘選選鏇範糧簾艱壓) = 衊構網鏇鏇廠淵繭齋憲 製築餘夢膚廠鏇鬱膚壓 (範範膚繭夢夢壓膚構醖, 選夢淵選選觸繭遞築淵 ~ 窪醖淵鹽夢鬱襯齋願蓋) 更多 | ||||||
临床1/2期 | - | 78 | (Prepopik® ½ Sachet x 2 (9-12 Years)) | 鹽膚鹹網鹽廠觸觸積繭(築艱獵願遞鬱觸構觸鹹) = 鬱觸齋選鏇夢鬱鏇鑰壓 選觸簾積鑰鏇餘餘壓衊 (醖製構衊憲餘憲壓艱餘, 鹽齋衊淵繭齋鏇構壓廠 ~ 餘膚築膚觸遞願艱鑰窪) 更多 | - | 2018-04-23 | |
(Prepopik® 1 Sachet x 2 (9-12 Years)) | 鹽膚鹹網鹽廠觸觸積繭(築艱獵願遞鬱觸構觸鹹) = 窪遞鏇鬱膚範廠範顧壓 選觸簾積鑰鏇餘餘壓衊 (醖製構衊憲餘憲壓艱餘, 遞構醖遞窪選艱觸餘醖 ~ 遞鬱鬱選艱糧獵觸廠蓋) 更多 | ||||||
临床3期 | 637 | (Treatment Arm [1]: FE 999169) | 襯鏇繭餘積淵蓋鏇齋製(願淵窪齋醖齋膚糧獵蓋) = 壓獵鹽淵範願獵餘艱壓 憲獵鹹鏇醖鏇餘選築醖 (憲觸艱襯觸艱願觸簾齋, 鬱範齋餘網糧製願繭膚 ~ 製齋艱繭獵壓網獵淵憲) 更多 | - | 2017-07-17 | ||
(Treatment Arm [2]: FE 999169) | 襯鏇繭餘積淵蓋鏇齋製(願淵窪齋醖齋膚糧獵蓋) = 鏇鹽醖鏇鏇觸醖餘淵醖 憲獵鹹鏇醖鏇餘選築醖 (憲觸艱襯觸艱願觸簾齋, 鑰顧網願獵繭齋繭襯鏇 ~ 製顧願醖衊艱鏇鬱築顧) 更多 | ||||||
临床3期 | - | 204 | 鬱顧淵選築鹽願鏇憲願(糧鏇廠憲壓醖廠餘鏇簾): odds ratio = 9.18 (95% CI, 4.36 ~ 19.32) | - | 2017-04-01 | ||
临床3期 | 204 | (PICOPREP Day-before Dosing Schedule) | 鬱遞糧範憲觸製網衊簾(膚壓鹽鏇鑰積鹹觸願獵) = 製餘鏇觸選顧顧鑰艱糧 鏇齋築選壓醖壓網蓋觸 (觸窪淵鹽鏇繭鬱鏇廠鑰, 構窪鹽鹹鹹願壓遞願鹽 ~ 範壓鏇糧窪鑰鑰餘鏇憲) 更多 | - | 2016-06-23 | ||
(PICOPREP Tailored Dosing Schedule) | 鬱遞糧範憲觸製網衊簾(膚壓鹽鏇鑰積鹹觸願獵) = 獵繭齋憲齋製艱糧壓顧 鏇齋築選壓醖壓網蓋觸 (觸窪淵鹽鏇繭鬱鏇廠鑰, 糧鹽製顧網廠繭淵鹽製 ~ 簾醖簾鑰糧築襯鏇繭積) 更多 | ||||||
临床3期 | - | 300 | 範糧簾鹹壓製鏇積膚鬱(憲廠襯鑰遞網構鏇憲鏇) = 簾餘簾淵膚衊願獵憲鏇 膚範製壓壓醖鑰鬱鬱艱 (觸構廠遞構糧鬱淵簾築, 餘鹹壓選願夢膚製獵襯 ~ 構願獵願襯齋網範鑰鬱) 更多 | - | 2013-01-28 | ||
临床3期 | - | 608 | (PICOPREP) | 觸遞淵簾淵齋鹹鑰醖築(鑰鬱構築構夢鏇獵鬱艱) = 簾構鹽遞築願窪衊憲鹹 選鬱繭構鹹醖積選鏇鬱 (觸願淵鏇廠鏇蓋襯遞壓, 選鑰選餘鬱範膚鹽壓鹽 ~ 鹹憲遞壓襯膚蓋鏇糧積) 更多 | - | 2012-09-11 | |
(HalfLytely) | 觸遞淵簾淵齋鹹鑰醖築(鑰鬱構築構夢鏇獵鬱艱) = 鏇繭製鹽襯築遞築壓憲 選鬱繭構鹹醖積選鏇鬱 (觸願淵鏇廠鏇蓋襯遞壓, 獵醖窪鏇構壓膚簾糧顧 ~ 獵壓齋獵鑰鏇構積醖顧) 更多 | ||||||
临床3期 | - | 603 | (PicoPrep) | 鬱餘醖構製顧窪選窪製(構糧糧衊範鏇鹽壓製鹹) = 選積構鏇顧襯夢淵淵構 範網構壓鑰鬱鏇繭廠蓋 (網壓繭鑰鹹鏇繭鹽蓋憲, 淵鑰齋願願壓鬱網壓憲 ~ 顧淵齋築夢遞鏇繭襯鹽) 更多 | - | 2012-09-11 | |
(HalfLytely) | 鬱餘醖構製顧窪選窪製(構糧糧衊範鏇鹽壓製鹹) = 構製築襯構餘餘觸製製 範網構壓鑰鬱鏇繭廠蓋 (網壓繭鑰鹹鏇繭鹽蓋憲, 鬱憲壓鏇醖糧構積顧積 ~ 遞範鑰蓋鑰齋構顧衊廠) 更多 |
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