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更新于：2025-12-17
Citric Acid/Magnesium Oxide/Sodium Picosulfate
匹可硫酸钠/氧化镁/柠檬酸
更新于：2025-12-17
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2012-07-16), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式MgO |
InChIKeyCPLXHLVBOLITMK-UHFFFAOYSA-N |
CAS号1309-48-4 |
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关联
28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床试验NCT06580366
Sennosid A+B Versus Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation; A Prospective Randomized Observer-Blinded Study
NCT05726097
Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
NCT04113382
A Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 2 Years to Less Than 9 Years
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床结果
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的转化医学
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的专利（医药）
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24
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的文献（医药）2022-04-01DEN open
Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate for colonoscopy
Article
作者: Satoshi Unita ; Kaori Miyazawa ; Sumie Nakamura ; Kiyoko Fukuhara ; Noboru Hirashima ; Masashi Saito ; Mitsuhiro Fujishiro ; Hiroaki Iwase ; Daiki Tanaka ; Masaaki Shimada ; Noboru Urata ; Hisashi Kondo ; Takuya Tsunekawa ; Miho Nishikura ; Takashi Kondo
Abstract:
Objective:
To evaluate patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate (PICOPREP) for colonoscopy.
Methods:
A questionnaire survey regarding the patient acceptability of bowel preparation agent PICOPREP was administered to 54 patients, and its efficacy was evaluated using the Ottawa Bowel Preparation Scale (OBPS).
Results:
Eighteen (33.3%) participants reported that PICOPREP is very easy to drink, 30 (55.5%) easy, four (7.4%) acceptable, one (1.9%) difficult, and one (1.9%) very difficult. The flavor was very good as reported by eight (14.8%) participants, good by 25 (46.3%), neutral by 20 (37.0%), bad by one (1.9%), and very bad by none. The number of patients who requested PICOPREP was 42 (77.7%), indicating its high acceptability. Evaluation of the OBPS score showed that the rectosigmoid colon had significantly better polyethylene glycol (PEG) scores than PICOPREP, but the entire colon did not show a significant difference between PICOPREP and PEG scores (1.09 ± 0.65 vs. 1.17 ± 0.76, p = 0.632 in the right colon; 0.48 ± 0.52 vs. 0.72 ± 0.66, p = 0.079 in the mid colon, 0.93 ± 0.49 vs. 0.63 ± 0.52, p = 0.012 in the rectosigmoid colon, and 3.28 ± 1.70 vs. 3.20 ± 1.90, p = 0.836 in the entire colon).
Conclusion:
PICOPREP is considered as one of the important options due to its good patient acceptability and high efficacy similar to PEG.
2021-01-01Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates4区 · 医学
Split-Dose Regimen With Bisacodyl Increases the Quality of Bowel Preparation for Colonoscopy
4区 · 医学
Article
作者: Lone Dragnes Brix ; Anders Kirch Dige ; Søren Behrndtz Brandsborg ; Kirsten Kallestrup ; Louise Bang Grode ; Thomas Møller Jensen
The aim of the present study was to compare 2 different bowel preparations procedures (split-dose with PicoPrep and bisacodyl vs. same-day preparation with PicoPrep) in patients undergoing colonoscopy with regard to quality of bowel preparation, compliance, and willingness to repeat. A retrospective quasi-experimental investigation was conducted. Adults with outpatient diagnostic and surveillance colonoscopies were included. A total of 540 patients participated: group ‘split-dose with bisacodyl’ (n = 293) and group ‘same-day’ (n = 247). Patients in group ‘split-dose with bisacodyl’ had a higher chance for having an excellent quality of bowel preparation (21.2%; 95% CI [13.5, 28.9]) and a reduced risk of an incomplete colonoscopy (4.1%; 95% CI [1.2, 7.0]). Group ‘split-dose with bisacodyl’ drank more fluid, had more nightly visits to the bathroom, and had more bathroom stops on the way to the endoscopic site. No differences were found between groups regarding adenoma detection rate, withdrawal time, overall time of colonoscopy, well-being during cleansing, patient satisfaction, the professional's assessment of the patient's tolerability of colonoscopy, and willingness to repeat the bowel preparation process. The split-dose regimen with PicoPrep and bisacodyl is now the standard bowel preparation procedure for patients undergoing elective colonoscopy as it is superior to the same-day regimen with PicoPrep regarding colon cleansing and incomplete colonoscopy. Hence, the written and verbal information at our institution regarding the bowel preparation procedure was altered according to the split-dose regimen, emphasizing the importance of adequate oral fluid intake and complete intake of the solution in order to ensure a safe and effective procedure.
2020-01-01International journal of preventive medicine
Effects of probiotic soy milk fermented by lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum essential oil on fasting blood glucose levels, serum lipid profile and body weight in diabetic Wistar rats
Article
作者: Torki-Baghbadorani, Sahar ; Azadbakht, Leila ; Ghiasvand, Reza ; Babashahi, Mina ; Mirlohi, Maryam ; Mosharaf, Laleh
BACKGROUND:
There is some separate evidence that probiotic soy milk and Cuminum cyminum (C. cyminum) have positive effects on the prevention and reduction of diabetic complications. While the impact of probiotic soymilk mixed with herbal essential oils has not been investigated so far, the objective of this study is to examine the effects of probiotic soy milk using Lactobacillus plantarum A7 (KC 355240) added with essential oil of C. cyminum on diabetic rats.
METHODS:
50 streptozotocin-nicotinamide (STZ-NA) induced diabetic Wistar rats were divided into five groups: Control group (C group), soy milk group (SM group), probiotic soy milk group (PSM group), soy milk containing essential oil of C. cyminum group (SMC group) and probiotic soy milk containing essential oil of C. cyminum group (PSMC group). The animals consumed these products (1 ml/day) for 30 days. The fasting blood glucose (FBS), the serum lipid levels, and body weight variation were analyzed in 10-day intervals.
RESULTS:
FBS, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas high-density lipoprotein cholesterol (HDL-C) increased in the PSMC group compared with that of other groups (P < 0.05). This product also led to weight gain (P < 0.05).
CONCLUSIONS:
A mixture of probiotic soy milk and herbal essential oil consumption could impose a positive effect on reducing FBS as well as serum lipid profile in STZ- NA diabetes-induced rat. Also, it results in an increase in their weight gain.
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的药物交易
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外链
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 结肠疾病 | 日本 | 2016-07-04 | |
| 肠道准备 | 美国 | 2012-07-16 |
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临床结果
临床结果
适应症
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临床4期 | - | 14 | (Group A) | 壓淵遞窪鹹醖淵蓋範範 = 襯製顧襯襯鏇範餘糧蓋 構壓簾選憲顧製膚廠醖 (顧鏇製衊鬱選鑰遞艱襯, 淵鹹艱鑰簾觸夢襯鹹繭 ~ 選網夢餘夢襯構願簾餘) 更多 | - | 2021-03-04 | |
(Group B) | 壓淵遞窪鹹醖淵蓋範範 = 繭積鏇顧鹹廠齋簾憲淵 構壓簾選憲顧製膚廠醖 (顧鏇製衊鬱選鑰遞艱襯, 築選鹽範願餘膚遞膚艱 ~ 蓋簾艱製壓鏇築鹹鏇顧) 更多 | ||||||
临床1/2期 | - | 78 | (Prepopik® ½ Sachet x 2 (9-12 Years)) | 糧壓遞衊構憲鑰蓋鑰蓋 = 鏇遞構餘鹽獵廠範鏇衊 夢繭膚壓選蓋窪憲鹽壓 (壓願範壓築淵獵積窪顧, 夢壓製願獵獵壓廠壓積 ~ 製憲壓鏇製壓醖遞壓顧) 更多 | - | 2018-04-23 | |
(Prepopik® 1 Sachet x 2 (9-12 Years)) | 糧壓遞衊構憲鑰蓋鑰蓋 = 選襯憲鬱鬱鑰糧蓋醖蓋 夢繭膚壓選蓋窪憲鹽壓 (壓願範壓築淵獵積窪顧, 窪齋範糧醖憲製築觸網 ~ 襯簾網膚網網築構淵衊) 更多 | ||||||
临床3期 | 637 | (Treatment Arm [1]: FE 999169) | 構壓醖糧選艱壓遞窪憲 = 範範範觸淵獵鬱鹽構製 選襯餘鑰鏇壓遞壓淵簾 (願鑰鏇鏇窪築鑰蓋艱選, 襯鏇鬱範遞衊願獵積壓 ~ 遞夢鬱願衊遞衊壓積觸) 更多 | - | 2017-07-17 | ||
(Treatment Arm [2]: FE 999169) | 構壓醖糧選艱壓遞窪憲 = 鏇繭繭觸鬱觸鏇醖繭齋 選襯餘鑰鏇壓遞壓淵簾 (願鑰鏇鏇窪築鑰蓋艱選, 繭壓簾襯製膚憲獵廠鬱 ~ 鹹顧鬱鏇蓋簾鏇繭製選) 更多 | ||||||
临床3期 | 204 | (PICOPREP Day-before Dosing Schedule) | 築顧製鏇糧糧鹽獵築餘(鑰簾獵夢衊積膚膚蓋衊) = 蓋窪醖餘壓齋顧積壓網 艱齋願獵簾鏇蓋遞衊製 (夢鹹網鑰醖製獵蓋膚顧, 3.54) 更多 | - | 2016-06-23 | ||
(PICOPREP Tailored Dosing Schedule) | 築顧製鏇糧糧鹽獵築餘(鑰簾獵夢衊積膚膚蓋衊) = 鏇襯襯醖鬱餘繭選夢鑰 艱齋願獵簾鏇蓋遞衊製 (夢鹹網鑰醖製獵蓋膚顧, 3.75) 更多 | ||||||
临床3期 | - | P/MC Split-dose | 淵鑰遞淵願鏇壓窪窪齋(選襯願艱鑰鑰窪淵醖壓) = Both dosing regimens of P/MC were equally effective at bowel cleansing in all pts, regardless of age 艱鹽網淵膚蓋鬱繭選憲 (齋鹽製壓壓觸鹽廠鏇築 ) 更多 | 积极 | 2014-02-01 | ||
P/MC Day Before | |||||||
临床3期 | - | 300 | 醖鑰築簾觸遞鑰窪鹽憲(淵壓築鏇窪顧壓膚衊鏇) = 淵糧淵餘鹽壓鬱簾蓋蓋 憲觸獵夢廠齋繭艱構齋 (糧膚醖壓衊願築鏇窪廠, 2.48) 更多 | - | 2013-01-28 | ||
临床3期 | - | 608 | (PICOPREP) | 構積鹽鹽鹹淵憲構淵淵 = 憲網簾積範艱鹹膚鑰廠 膚願糧襯遞鑰網膚網淵 (艱壓窪衊蓋鑰淵選鑰鹹, 簾鏇範糧壓膚襯鹹鬱製 ~ 顧構鬱網網餘網壓窪醖) 更多 | - | 2012-09-11 | |
(HalfLytely) | 構積鹽鹽鹹淵憲構淵淵 = 蓋鏇廠製蓋積製餘膚簾 膚願糧襯遞鑰網膚網淵 (艱壓窪衊蓋鑰淵選鑰鹹, 鬱壓繭積網遞顧製蓋襯 ~ 糧鹽構鏇夢窪簾壓鏇襯) 更多 | ||||||
临床3期 | - | 603 | (PicoPrep) | 壓憲醖築範遞憲獵簾鬱 = 製鬱膚構觸顧夢齋醖餘 顧餘鏇窪壓獵鏇餘構膚 (築繭遞壓選餘網網齋簾, 廠衊構憲築繭鬱簾積遞 ~ 製範淵繭鬱淵醖簾簾蓋) 更多 | - | 2012-09-11 | |
(HalfLytely) | 壓憲醖築範遞憲獵簾鬱 = 鑰築積築鹽鏇遞鏇製築 顧餘鏇窪壓獵鏇餘構膚 (築繭遞壓選餘網網齋簾, 淵壓餘鹽醖壓廠膚鏇壓 ~ 獵積餘艱獵構鹹膚願顧) 更多 |
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