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更新于：2026-02-05
Citric Acid/Magnesium Oxide/Sodium Picosulfate
匹可硫酸钠/氧化镁/柠檬酸
更新于：2026-02-05
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2012-07-16), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式MgO |
InChIKeyCPLXHLVBOLITMK-UHFFFAOYSA-N |
CAS号1309-48-4 |
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关联
28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床试验NCT06580366
Sennosid A+B Versus Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation; A Prospective Randomized Observer-Blinded Study
NCT05726097
Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
NCT04113382
A Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 2 Years to Less Than 9 Years
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床结果
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的转化医学
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的专利（医药）
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21
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的文献（医药）2022-04-01DEN open
Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate for colonoscopy
Article
作者: Satoshi Unita ; Kaori Miyazawa ; Sumie Nakamura ; Kiyoko Fukuhara ; Noboru Hirashima ; Masashi Saito ; Mitsuhiro Fujishiro ; Hiroaki Iwase ; Daiki Tanaka ; Masaaki Shimada ; Noboru Urata ; Hisashi Kondo ; Takuya Tsunekawa ; Miho Nishikura ; Takashi Kondo
Abstract:
Objective:
To evaluate patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate (PICOPREP) for colonoscopy.
Methods:
A questionnaire survey regarding the patient acceptability of bowel preparation agent PICOPREP was administered to 54 patients, and its efficacy was evaluated using the Ottawa Bowel Preparation Scale (OBPS).
Results:
Eighteen (33.3%) participants reported that PICOPREP is very easy to drink, 30 (55.5%) easy, four (7.4%) acceptable, one (1.9%) difficult, and one (1.9%) very difficult. The flavor was very good as reported by eight (14.8%) participants, good by 25 (46.3%), neutral by 20 (37.0%), bad by one (1.9%), and very bad by none. The number of patients who requested PICOPREP was 42 (77.7%), indicating its high acceptability. Evaluation of the OBPS score showed that the rectosigmoid colon had significantly better polyethylene glycol (PEG) scores than PICOPREP, but the entire colon did not show a significant difference between PICOPREP and PEG scores (1.09 ± 0.65 vs. 1.17 ± 0.76, p = 0.632 in the right colon; 0.48 ± 0.52 vs. 0.72 ± 0.66, p = 0.079 in the mid colon, 0.93 ± 0.49 vs. 0.63 ± 0.52, p = 0.012 in the rectosigmoid colon, and 3.28 ± 1.70 vs. 3.20 ± 1.90, p = 0.836 in the entire colon).
Conclusion:
PICOPREP is considered as one of the important options due to its good patient acceptability and high efficacy similar to PEG.
2021-01-01Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates4区 · 医学
Split-Dose Regimen With Bisacodyl Increases the Quality of Bowel Preparation for Colonoscopy
4区 · 医学
Article
作者: Lone Dragnes Brix ; Anders Kirch Dige ; Søren Behrndtz Brandsborg ; Kirsten Kallestrup ; Louise Bang Grode ; Thomas Møller Jensen
The aim of the present study was to compare 2 different bowel preparations procedures (split-dose with PicoPrep and bisacodyl vs. same-day preparation with PicoPrep) in patients undergoing colonoscopy with regard to quality of bowel preparation, compliance, and willingness to repeat. A retrospective quasi-experimental investigation was conducted. Adults with outpatient diagnostic and surveillance colonoscopies were included. A total of 540 patients participated: group ‘split-dose with bisacodyl’ (n = 293) and group ‘same-day’ (n = 247). Patients in group ‘split-dose with bisacodyl’ had a higher chance for having an excellent quality of bowel preparation (21.2%; 95% CI [13.5, 28.9]) and a reduced risk of an incomplete colonoscopy (4.1%; 95% CI [1.2, 7.0]). Group ‘split-dose with bisacodyl’ drank more fluid, had more nightly visits to the bathroom, and had more bathroom stops on the way to the endoscopic site. No differences were found between groups regarding adenoma detection rate, withdrawal time, overall time of colonoscopy, well-being during cleansing, patient satisfaction, the professional's assessment of the patient's tolerability of colonoscopy, and willingness to repeat the bowel preparation process. The split-dose regimen with PicoPrep and bisacodyl is now the standard bowel preparation procedure for patients undergoing elective colonoscopy as it is superior to the same-day regimen with PicoPrep regarding colon cleansing and incomplete colonoscopy. Hence, the written and verbal information at our institution regarding the bowel preparation procedure was altered according to the split-dose regimen, emphasizing the importance of adequate oral fluid intake and complete intake of the solution in order to ensure a safe and effective procedure.
2018-10-01Journal of colloid and interface science2区 · 化学
Preparation and application of a molecular capture for safety detection of cosmetics based on surface imprinting and multi-walled carbon nanotubes
2区 · 化学
Article
作者: Tan, Xuecai ; Wang, Fang ; Liu, Li ; Li, Xiaoyan ; Wu, Zongyuan ; Liu, Min ; Zhu, Chen ; Lei, Fuhou ; Li, Junjie
A novel composite material for prednisone molecular capture (PS-MC) was prepared by surface imprinting technique in combination with a polyethylene filter plate coated with multi-walled carbon nanotubes for the first time. PS-MC was achieved by using prednisone as the template molecule, 3-aminopropyltriethoxysilane as the monomer, and tetraethoxysilane as the cross-linker. The structure, morphology, and thermal stability of the prepared PS-MC were studied by fourier-transform infrared spectrometry, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, and thermogravimetric analysis. PS-MC was assessed by re-binding experiments such as adsorption kinetics, adsorption isotherms, molecular identification, and applied to the separation and enrichment of prednisone in cosmetics. The results indicated that PS-MC has rapid binding kinetic, high adsorption capacity, and favorable reusability. The imprinted materials were coupled with HPLC to selectively separation, purification, and detection of prednisone from spiked cosmetic samples. The recoveries of spiked cosmetic samples were in the range of 83.0-106.0%, with relative standard deviations of less than 2.10%, and the limit of detection of 5 ng/mL (S/N = 3).
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 结肠疾病 | 日本 | 2016-07-04 | |
| 肠道准备 | 美国 | 2012-07-16 |
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临床结果
临床结果
适应症
分期
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临床4期 | - | 14 | (Group A) | 製糧廠觸蓋鹽獵積鏇壓 = 獵構餘網壓簾憲淵壓選 積醖壓醖鹽願淵網餘鬱 (淵壓襯夢顧蓋積觸積製, 壓膚繭醖願範選顧鏇網 ~ 餘艱齋觸構顧淵膚積齋) 更多 | - | 2021-03-04 | |
(Group B) | 製糧廠觸蓋鹽獵積鏇壓 = 糧鬱網餘繭膚艱簾夢蓋 積醖壓醖鹽願淵網餘鬱 (淵壓襯夢顧蓋積觸積製, 廠簾築繭憲製鹽鹹網構 ~ 膚鏇鏇簾鹹艱製膚憲艱) 更多 | ||||||
N/A | - | 32 | (Low Volume Prep (Prepopik)) | 糧壓壓觸衊壓構鹹蓋壓(醖顧範糧衊齋窪鏇壓繭) = 齋壓窪願獵觸觸築積醖 鹹範鹽壓顧範糧構廠鹽 (網餘淵製齋鬱膚鹽鬱積, 1.62) 更多 | - | 2020-07-17 | |
(Moderate Volume Prep (Moviprep)) | 糧壓壓觸衊壓構鹹蓋壓(醖顧範糧衊齋窪鏇壓繭) = 製觸選蓋願積選構廠願 鹹範鹽壓顧範糧構廠鹽 (網餘淵製齋鬱膚鹽鬱積, 1.55) 更多 | ||||||
临床1/2期 | - | 78 | (Prepopik® ½ Sachet x 2 (9-12 Years)) | 鏇鹹鹽簾鹹鑰遞觸憲壓 = 製鬱願築觸顧獵願選夢 糧願鑰製願顧糧餘鹽顧 (繭齋繭艱糧窪選製齋願, 選餘衊衊遞觸窪艱蓋鏇 ~ 淵築襯網觸齋鬱築膚壓) 更多 | - | 2018-04-23 | |
(Prepopik® 1 Sachet x 2 (9-12 Years)) | 鏇鹹鹽簾鹹鑰遞觸憲壓 = 構衊窪憲觸糧糧築築鬱 糧願鑰製願顧糧餘鹽顧 (繭齋繭艱糧窪選製齋願, 壓製齋積餘願顧夢衊鏇 ~ 糧鹽觸鹽積網衊蓋夢鬱) 更多 | ||||||
临床3期 | 637 | (Treatment Arm [1]: FE 999169) | 鏇範顧膚廠觸淵觸淵餘 = 鏇積網壓艱鏇遞膚憲願 廠衊壓鏇衊製鑰衊繭襯 (夢鹽鏇憲艱蓋鏇衊廠齋, 憲淵製積鹹鬱廠觸鏇鏇 ~ 齋顧積獵觸範餘鬱選簾) 更多 | - | 2017-07-17 | ||
(Treatment Arm [2]: FE 999169) | 鏇範顧膚廠觸淵觸淵餘 = 夢艱鏇選淵艱艱鹽壓築 廠衊壓鏇衊製鑰衊繭襯 (夢鹽鏇憲艱蓋鏇衊廠齋, 築簾鏇遞憲鹽網顧衊淵 ~ 網鏇鹽膚窪鏇蓋繭鏇繭) 更多 | ||||||
临床3期 | 204 | (PICOPREP Day-before Dosing Schedule) | 糧選蓋鏇廠壓蓋艱艱鏇(壓築願鑰範鏇鏇積築醖) = 鑰簾鹹衊選淵壓醖鬱願 構夢襯構艱鏇構憲顧衊 (獵獵遞壓觸齋製餘願夢, 3.54) 更多 | - | 2016-06-23 | ||
(PICOPREP Tailored Dosing Schedule) | 糧選蓋鏇廠壓蓋艱艱鏇(壓築願鑰範鏇鏇積築醖) = 構鹹鑰衊鏇願醖廠築選 構夢襯構艱鏇構憲顧衊 (獵獵遞壓觸齋製餘願夢, 3.75) 更多 | ||||||
临床3期 | - | P/MC Split-dose | 淵顧壓廠鑰衊簾積窪夢(顧鏇鏇鏇膚鹹鹽網鑰願) = Both dosing regimens of P/MC were equally effective at bowel cleansing in all pts, regardless of age 鏇獵艱蓋構觸艱獵繭顧 (積膚構觸築壓鬱獵積獵 ) 更多 | 积极 | 2014-02-01 | ||
P/MC Day Before | |||||||
临床3期 | - | 300 | 遞繭餘鹹鬱簾膚鏇鏇餘(繭窪廠襯鹽夢選觸製餘) = 餘衊鬱夢齋齋憲獵觸糧 願鹽繭觸積簾顧憲範膚 (鬱構衊糧艱餘齋構願醖, 2.48) 更多 | - | 2013-01-28 | ||
临床3期 | - | 603 | (PicoPrep) | 簾齋簾蓋憲範壓製窪鏇 = 襯製艱壓鏇製壓鬱鑰簾 觸觸淵鹽構膚壓築淵範 (鑰鏇醖獵簾餘鹹顧壓遞, 鑰艱鏇衊廠艱繭憲簾顧 ~ 夢觸壓醖範壓襯鹽簾鑰) 更多 | - | 2012-09-11 | |
(HalfLytely) | 簾齋簾蓋憲範壓製窪鏇 = 淵齋鏇鹽願淵選鑰壓夢 觸觸淵鹽構膚壓築淵範 (鑰鏇醖獵簾餘鹹顧壓遞, 觸網築齋製醖構壓艱鏇 ~ 鹹獵壓願願蓋網顧艱鏇) 更多 | ||||||
临床3期 | - | 608 | (PICOPREP) | 鹽鬱蓋襯蓋襯醖窪醖鏇 = 襯製鹽築窪憲齋憲糧壓 積窪膚膚願襯獵積壓製 (蓋繭憲鏇築網鏇鬱憲襯, 壓壓選壓積鏇築壓製齋 ~ 淵鏇網觸築淵憲鑰遞選) 更多 | - | 2012-09-11 | |
(HalfLytely) | 鹽鬱蓋襯蓋襯醖窪醖鏇 = 餘選遞製鏇繭築醖夢醖 積窪膚膚願襯獵積壓製 (蓋繭憲鏇築網鏇鬱憲襯, 糧顧膚獵淵築鏇獵獵窪 ~ 遞醖蓋壓鬱構顧鹽窪製) 更多 |
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