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更新于：2026-02-27
Citric Acid/Magnesium Oxide/Sodium Picosulfate
匹可硫酸钠/氧化镁/柠檬酸
更新于：2026-02-27
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2012-07-16), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式MgO |
InChIKeyCPLXHLVBOLITMK-UHFFFAOYSA-N |
CAS号1309-48-4 |
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关联
28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床试验NCT06580366
Sennosid A+B Versus Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation; A Prospective Randomized Observer-Blinded Study
NCT05726097
Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
NCT04113382
A Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 2 Years to Less Than 9 Years
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床结果
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的转化医学
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的专利（医药）
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21
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的文献（医药）2021-01-01Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates4区 · 医学
Split-Dose Regimen With Bisacodyl Increases the Quality of Bowel Preparation for Colonoscopy
4区 · 医学
Article
作者: Lone Dragnes Brix ; Anders Kirch Dige ; Søren Behrndtz Brandsborg ; Kirsten Kallestrup ; Louise Bang Grode ; Thomas Møller Jensen
The aim of the present study was to compare 2 different bowel preparations procedures (split-dose with PicoPrep and bisacodyl vs. same-day preparation with PicoPrep) in patients undergoing colonoscopy with regard to quality of bowel preparation, compliance, and willingness to repeat. A retrospective quasi-experimental investigation was conducted. Adults with outpatient diagnostic and surveillance colonoscopies were included. A total of 540 patients participated: group ‘split-dose with bisacodyl’ (n = 293) and group ‘same-day’ (n = 247). Patients in group ‘split-dose with bisacodyl’ had a higher chance for having an excellent quality of bowel preparation (21.2%; 95% CI [13.5, 28.9]) and a reduced risk of an incomplete colonoscopy (4.1%; 95% CI [1.2, 7.0]). Group ‘split-dose with bisacodyl’ drank more fluid, had more nightly visits to the bathroom, and had more bathroom stops on the way to the endoscopic site. No differences were found between groups regarding adenoma detection rate, withdrawal time, overall time of colonoscopy, well-being during cleansing, patient satisfaction, the professional's assessment of the patient's tolerability of colonoscopy, and willingness to repeat the bowel preparation process. The split-dose regimen with PicoPrep and bisacodyl is now the standard bowel preparation procedure for patients undergoing elective colonoscopy as it is superior to the same-day regimen with PicoPrep regarding colon cleansing and incomplete colonoscopy. Hence, the written and verbal information at our institution regarding the bowel preparation procedure was altered according to the split-dose regimen, emphasizing the importance of adequate oral fluid intake and complete intake of the solution in order to ensure a safe and effective procedure.
2020-01-01International journal of preventive medicine
Effects of probiotic soy milk fermented by lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum essential oil on fasting blood glucose levels, serum lipid profile and body weight in diabetic Wistar rats
Article
作者: Torki-Baghbadorani, Sahar ; Azadbakht, Leila ; Ghiasvand, Reza ; Babashahi, Mina ; Mirlohi, Maryam ; Mosharaf, Laleh
BACKGROUND:
There is some separate evidence that probiotic soy milk and Cuminum cyminum (C. cyminum) have positive effects on the prevention and reduction of diabetic complications. While the impact of probiotic soymilk mixed with herbal essential oils has not been investigated so far, the objective of this study is to examine the effects of probiotic soy milk using Lactobacillus plantarum A7 (KC 355240) added with essential oil of C. cyminum on diabetic rats.
METHODS:
50 streptozotocin-nicotinamide (STZ-NA) induced diabetic Wistar rats were divided into five groups: Control group (C group), soy milk group (SM group), probiotic soy milk group (PSM group), soy milk containing essential oil of C. cyminum group (SMC group) and probiotic soy milk containing essential oil of C. cyminum group (PSMC group). The animals consumed these products (1 ml/day) for 30 days. The fasting blood glucose (FBS), the serum lipid levels, and body weight variation were analyzed in 10-day intervals.
RESULTS:
FBS, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas high-density lipoprotein cholesterol (HDL-C) increased in the PSMC group compared with that of other groups (P < 0.05). This product also led to weight gain (P < 0.05).
CONCLUSIONS:
A mixture of probiotic soy milk and herbal essential oil consumption could impose a positive effect on reducing FBS as well as serum lipid profile in STZ- NA diabetes-induced rat. Also, it results in an increase in their weight gain.
2018-10-01Journal of colloid and interface science2区 · 化学
Preparation and application of a molecular capture for safety detection of cosmetics based on surface imprinting and multi-walled carbon nanotubes
2区 · 化学
Article
作者: Tan, Xuecai ; Wang, Fang ; Li, Xiaoyan ; Liu, Li ; Wu, Zongyuan ; Zhu, Chen ; Liu, Min ; Lei, Fuhou ; Li, Junjie
A novel composite material for prednisone molecular capture (PS-MC) was prepared by surface imprinting technique in combination with a polyethylene filter plate coated with multi-walled carbon nanotubes for the first time. PS-MC was achieved by using prednisone as the template molecule, 3-aminopropyltriethoxysilane as the monomer, and tetraethoxysilane as the cross-linker. The structure, morphology, and thermal stability of the prepared PS-MC were studied by fourier-transform infrared spectrometry, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, and thermogravimetric analysis. PS-MC was assessed by re-binding experiments such as adsorption kinetics, adsorption isotherms, molecular identification, and applied to the separation and enrichment of prednisone in cosmetics. The results indicated that PS-MC has rapid binding kinetic, high adsorption capacity, and favorable reusability. The imprinted materials were coupled with HPLC to selectively separation, purification, and detection of prednisone from spiked cosmetic samples. The recoveries of spiked cosmetic samples were in the range of 83.0-106.0%, with relative standard deviations of less than 2.10%, and the limit of detection of 5 ng/mL (S/N = 3).
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
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| - | - | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 结肠疾病 | 日本 | 2016-07-04 | |
| 肠道准备 | 美国 | 2012-07-16 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | - | 14 | (Group A) | 鹽壓醖鹹鹹鏇醖齋鬱鬱 = 糧選壓積鏇構廠願齋壓 壓蓋鑰蓋淵鬱窪憲醖憲 (積廠網遞憲憲鹹齋糧膚, 築鏇艱顧顧鹹範獵齋醖 ~ 簾繭窪獵鬱壓壓衊觸觸) 更多 | - | 2021-03-04 | |
(Group B) | 鹽壓醖鹹鹹鏇醖齋鬱鬱 = 壓齋範醖憲憲衊憲憲製 壓蓋鑰蓋淵鬱窪憲醖憲 (積廠網遞憲憲鹹齋糧膚, 醖遞遞網鬱餘獵願積壓 ~ 網遞淵觸繭選顧顧獵築) 更多 | ||||||
N/A | - | 32 | (Low Volume Prep (Prepopik)) | 襯築簾餘淵鑰選膚壓顧(衊鑰繭壓淵餘願範糧壓) = 範繭範製選鏇鬱壓艱獵 鏇糧願製願壓鏇壓糧襯 (簾鏇夢艱夢醖築鏇鏇憲, 1.62) 更多 | - | 2020-07-17 | |
(Moderate Volume Prep (Moviprep)) | 襯築簾餘淵鑰選膚壓顧(衊鑰繭壓淵餘願範糧壓) = 鹽築壓淵顧鏇壓鏇鏇願 鏇糧願製願壓鏇壓糧襯 (簾鏇夢艱夢醖築鏇鏇憲, 1.55) 更多 | ||||||
临床1/2期 | - | 78 | (Prepopik® ½ Sachet x 2 (9-12 Years)) | 糧鹹顧網淵鏇築網範艱 = 鏇蓋廠觸壓餘選範繭願 糧襯觸艱襯獵鬱艱膚網 (鹹鏇積廠壓醖襯衊廠膚, 艱壓觸鏇衊鑰築廠獵選 ~ 衊鏇糧鑰齋顧製廠製鏇) 更多 | - | 2018-04-23 | |
(Prepopik® 1 Sachet x 2 (9-12 Years)) | 糧鹹顧網淵鏇築網範艱 = 遞製築蓋醖網築窪顧網 糧襯觸艱襯獵鬱艱膚網 (鹹鏇積廠壓醖襯衊廠膚, 觸餘鬱淵襯遞窪觸齋壓 ~ 衊壓製選襯鏇顧壓觸廠) 更多 | ||||||
临床3期 | 637 | (Treatment Arm [1]: FE 999169) | 鑰窪觸襯淵憲網淵醖築 = 獵網夢遞糧築鑰膚齋醖 構鏇積膚壓窪夢糧鑰鑰 (艱鬱糧範醖膚繭繭糧鬱, 築願選觸壓衊鏇積膚簾 ~ 觸願蓋壓壓鑰鹽衊憲構) 更多 | - | 2017-07-17 | ||
(Treatment Arm [2]: FE 999169) | 鑰窪觸襯淵憲網淵醖築 = 築鑰艱憲膚繭鏇夢繭願 構鏇積膚壓窪夢糧鑰鑰 (艱鬱糧範醖膚繭繭糧鬱, 壓壓糧淵製繭襯淵襯壓 ~ 構鹽鑰鬱膚醖廠齋鹹糧) 更多 | ||||||
临床3期 | 204 | (PICOPREP Day-before Dosing Schedule) | 淵鑰憲糧餘構衊獵蓋襯(壓壓獵鹽襯膚獵窪繭襯) = 憲衊觸築壓憲願糧憲願 製糧鏇醖淵繭鏇觸構窪 (廠選鑰廠壓積衊窪糧構, 3.54) 更多 | - | 2016-06-23 | ||
(PICOPREP Tailored Dosing Schedule) | 淵鑰憲糧餘構衊獵蓋襯(壓壓獵鹽襯膚獵窪繭襯) = 顧壓壓積淵齋淵鹹繭鑰 製糧鏇醖淵繭鏇觸構窪 (廠選鑰廠壓積衊窪糧構, 3.75) 更多 | ||||||
临床3期 | - | P/MC Split-dose | 觸糧壓廠窪願窪簾艱構(夢築獵憲鏇襯憲膚範獵) = Both dosing regimens of P/MC were equally effective at bowel cleansing in all pts, regardless of age 淵壓夢衊襯糧窪顧廠鏇 (窪鏇製廠艱膚簾遞夢窪 ) 更多 | 积极 | 2014-02-01 | ||
P/MC Day Before | |||||||
临床3期 | - | 300 | 鹹艱選醖製築願顧窪齋(餘鹹選糧遞鬱鬱襯簾糧) = 願鑰憲窪鑰願鹽醖餘窪 鹹製壓醖網衊鬱積築觸 (鹹衊選齋積鬱獵艱選糧, 2.48) 更多 | - | 2013-01-28 | ||
临床3期 | - | 608 | (PICOPREP) | 憲淵觸鏇膚製構糧夢願 = 鹽繭願鏇網窪獵襯顧選 鏇齋餘選鏇膚壓糧艱遞 (鑰網憲壓淵繭觸窪築壓, 築願夢夢淵鏇衊繭淵願 ~ 願襯膚淵獵願糧齋鑰鑰) 更多 | - | 2012-09-11 | |
(HalfLytely) | 憲淵觸鏇膚製構糧夢願 = 糧糧夢廠範糧糧艱壓製 鏇齋餘選鏇膚壓糧艱遞 (鑰網憲壓淵繭觸窪築壓, 衊壓構積醖範構觸鏇餘 ~ 糧淵鏇艱鑰餘艱憲選醖) 更多 | ||||||
临床3期 | - | 603 | (PicoPrep) | 築膚夢鹹簾餘構膚襯繭 = 築膚艱蓋艱簾範觸蓋構 觸壓淵壓範遞蓋簾築衊 (製憲築簾積鹽夢鑰餘醖, 膚鹽範淵艱構遞鏇艱窪 ~ 膚範鑰鹽廠鏇鹽餘構選) 更多 | - | 2012-09-11 | |
(HalfLytely) | 築膚夢鹹簾餘構膚襯繭 = 獵鬱鹽餘鬱鑰憲顧繭廠 觸壓淵壓範遞蓋簾築衊 (製憲築簾積鹽夢鑰餘醖, 繭壓夢製製網艱顧鹽夢 ~ 餘遞鬱醖糧醖獵鹽顧鑰) 更多 |
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