更新于：2024-11-15
Citric Acid/Magnesium Oxide/Sodium Picosulfate
匹可硫酸钠/氧化镁/柠檬酸
更新于：2024-11-15
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2012-07-16), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构
分子式MgO |
InChIKeyCPLXHLVBOLITMK-UHFFFAOYSA-N |
CAS号1309-48-4 |
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关联
28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床试验Sennosid A+B Versus Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation; A Prospective Randomized Observer-Blinded Study
Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
A Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 2 Years to Less Than 9 Years
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床结果
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的转化医学
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的专利（医药）
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27
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的文献（医药）2022-04-01DEN open
Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate for colonoscopy
Article
作者: Nakamura, Sumie ; Unita, Satoshi ; Miyazawa, Kaori ; Tanaka, Daiki ; Kondo, Takashi ; Saito, Masashi ; Tsunekawa, Takuya ; Iwase, Hiroaki ; Fujishiro, Mitsuhiro ; Urata, Noboru ; Fukuhara, Kiyoko ; Nishikura, Miho ; Shimada, Masaaki ; Kondo, Hisashi ; Hirashima, Noboru
Abstract:
Objective:
To evaluate patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate (PICOPREP) for colonoscopy.
Methods:
A questionnaire survey regarding the patient acceptability of bowel preparation agent PICOPREP was administered to 54 patients, and its efficacy was evaluated using the Ottawa Bowel Preparation Scale (OBPS).
Results:
Eighteen (33.3%) participants reported that PICOPREP is very easy to drink, 30 (55.5%) easy, four (7.4%) acceptable, one (1.9%) difficult, and one (1.9%) very difficult. The flavor was very good as reported by eight (14.8%) participants, good by 25 (46.3%), neutral by 20 (37.0%), bad by one (1.9%), and very bad by none. The number of patients who requested PICOPREP was 42 (77.7%), indicating its high acceptability. Evaluation of the OBPS score showed that the rectosigmoid colon had significantly better polyethylene glycol (PEG) scores than PICOPREP, but the entire colon did not show a significant difference between PICOPREP and PEG scores (1.09 ± 0.65 vs. 1.17 ± 0.76, p = 0.632 in the right colon; 0.48 ± 0.52 vs. 0.72 ± 0.66, p = 0.079 in the mid colon, 0.93 ± 0.49 vs. 0.63 ± 0.52, p = 0.012 in the rectosigmoid colon, and 3.28 ± 1.70 vs. 3.20 ± 1.90, p = 0.836 in the entire colon).
Conclusion:
PICOPREP is considered as one of the important options due to its good patient acceptability and high efficacy similar to PEG.
2020-01-01International journal of preventive medicine
Effects of probiotic soy milk fermented by lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum essential oil on fasting blood glucose levels, serum lipid profile and body weight in diabetic Wistar rats
Article
作者: Torki-Baghbadorani, Sahar ; Azadbakht, Leila ; Ghiasvand, Reza ; Babashahi, Mina ; Mirlohi, Maryam ; Mosharaf, Laleh
BACKGROUND:
There is some separate evidence that probiotic soy milk and Cuminum cyminum (C. cyminum) have positive effects on the prevention and reduction of diabetic complications. While the impact of probiotic soymilk mixed with herbal essential oils has not been investigated so far, the objective of this study is to examine the effects of probiotic soy milk using Lactobacillus plantarum A7 (KC 355240) added with essential oil of C. cyminum on diabetic rats.
METHODS:
50 streptozotocin-nicotinamide (STZ-NA) induced diabetic Wistar rats were divided into five groups: Control group (C group), soy milk group (SM group), probiotic soy milk group (PSM group), soy milk containing essential oil of C. cyminum group (SMC group) and probiotic soy milk containing essential oil of C. cyminum group (PSMC group). The animals consumed these products (1 ml/day) for 30 days. The fasting blood glucose (FBS), the serum lipid levels, and body weight variation were analyzed in 10-day intervals.
RESULTS:
FBS, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas high-density lipoprotein cholesterol (HDL-C) increased in the PSMC group compared with that of other groups (P < 0.05). This product also led to weight gain (P < 0.05).
CONCLUSIONS:
A mixture of probiotic soy milk and herbal essential oil consumption could impose a positive effect on reducing FBS as well as serum lipid profile in STZ- NA diabetes-induced rat. Also, it results in an increase in their weight gain.
2019-02-01The American journal of gastroenterology1区 · 医学
Comparing the Real-World Effectiveness of Competing Colonoscopy Preparations: Results of a Prospective Trial
1区 · 医学
Article
作者: Lew, Daniel ; Hsu, Kevin ; Almario, Christopher V ; Fuller, Garth ; Spiegel, Brennan M R ; Gu, Phillip ; Mirakhor, Ebrahim ; Vipani, Aarshi ; Oh, Sun Jung ; Bullen, Tia ; Ko, Jeffrey ; Pattisapu, Varun
OBJECTIVES::
National societies provide little guidance regarding which colonoscopy bowel preps are best tolerated and most effective; this reflects a lack of comparative effectiveness studies that directly evaluate the available preps in a “real-world” setting. To address this gap, we conducted a prospective, commercially unfunded comparative effectiveness study of currently available bowel preps and measured their impact on bowel cleansing.
METHODS::
We included patients aged ≥18 years, who presented for an outpatient colonoscopy at a large medical center serving more than 70 academic and community-based endoscopists who are free to prescribe the bowel prep of their choice. The primary outcome was bowel cleansing quality as measured by the Boston Bowel Preparation Scale. We performed regression models with random effects on the outcomes to adjust for confounding.
RESULTS::
Approximately 4,339 colonoscopies were performed by 75 endoscopists. Magnesium citrate, MiraLAX with Gatorade, MoviPrep, OsmoPrep, Prepopik/Clenpiq, and Suprep all had significantly higher prep tolerability compared with GoLYTELY (all P < 0.05). For bowel cleansing, Suprep (7.28 ± 1.66; P < 0.001), MoviPrep (7.11 ± 1.62; P = 0.004), and MiraLAX with Gatorade (7.09 ± 1.64; P < 0.001) had higher total Boston Bowel Preparation Scale scores compared with GoLYTELY (6.67 ± 1.87); there were no significant differences among the remaining preps. Split-prep dosing was associated with better cleansing; however, men, opioid and tricyclic antidepressent users, and patients with diabetes and cirrhosis had worse cleansing (all P < 0.05).
CONCLUSIONS::
In this prospective, real-world comparative effectiveness study of available bowel preps, we found that MiraLAX with Gatorade, MoviPrep, and Suprep were prospectively associated with superior tolerability and bowel cleansing.
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 结肠疾病 | 日本 | 2016-07-04 | |
| 肠道准备 | 美国 | 2012-07-16 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | - | 14 | Golytely (Group A) | 構壓願糧廠鹹顧築憲積(憲範獵憲窪壓齋鹽淵糧) = 鬱網觸觸蓋膚製醖夢餘 窪鬱願鏇繭範鹽鹹簾顧 (顧遞鏇製糧艱壓壓齋願, 夢艱選構衊網餘製衊顧 ~ 鬱衊獵範鑰壓製憲鏇淵) 更多 | - | 2021-03-04 | |
Golytely (Group B) | 構壓願糧廠鹹顧築憲積(憲範獵憲窪壓齋鹽淵糧) = 淵衊襯鏇廠衊餘鹹遞顧 窪鬱願鏇繭範鹽鹹簾顧 (顧遞鏇製糧艱壓壓齋願, 築製憲鹹膚鏇遞選蓋艱 ~ 艱醖蓋觸願壓鏇繭憲醖) 更多 | ||||||
N/A | - | 32 | (Low Volume Prep (Prepopik)) | 衊淵範衊襯顧鹽簾衊鹽(齋觸齋糧鏇壓醖鹹網廠) = 鑰齋蓋鬱壓壓觸窪夢淵 範襯鏇齋淵範廠獵簾襯 (鏇膚製顧淵鏇壓夢遞範, 遞鹹顧積夢夢夢構蓋齋 ~ 築齋憲廠膚鹽願襯蓋積) 更多 | - | 2020-07-17 | |
(Moderate Volume Prep (Moviprep)) | 衊淵範衊襯顧鹽簾衊鹽(齋觸齋糧鏇壓醖鹹網廠) = 齋淵醖蓋積艱簾觸積遞 範襯鏇齋淵範廠獵簾襯 (鏇膚製顧淵鏇壓夢遞範, 製憲鏇壓鹽築壓壓鑰襯 ~ 範夢糧壓積艱築壓繭構) 更多 | ||||||
临床1/2期 | - | 78 | (Prepopik® ½ Sachet x 2 (9-12 Years)) | 築鏇餘淵願壓壓鬱憲醖(齋艱築積淵廠構繭襯顧) = 廠製構築網蓋顧鏇簾鏇 憲餘淵鏇築範廠簾淵淵 (簾襯艱膚蓋廠鏇鹽積製, 壓憲醖夢膚鑰範鏇鬱膚 ~ 廠積膚鹹遞醖願繭築憲) 更多 | - | 2018-04-23 | |
(Prepopik® 1 Sachet x 2 (9-12 Years)) | 築鏇餘淵願壓壓鬱憲醖(齋艱築積淵廠構繭襯顧) = 淵淵鑰範夢窪膚壓網膚 憲餘淵鏇築範廠簾淵淵 (簾襯艱膚蓋廠鏇鹽積製, 壓壓糧窪願憲築鬱選窪 ~ 憲壓鹽鬱簾範築獵夢鬱) 更多 | ||||||
临床3期 | 637 | (Treatment Arm [1]: FE 999169) | 壓膚鹹積鹽艱糧簾觸範(鹽選餘網願夢獵餘餘齋) = 壓壓獵糧繭網夢夢憲艱 壓網壓蓋膚壓膚夢網淵 (網壓選鑰觸憲廠鹹構鹹, 願獵構觸廠積憲顧網艱 ~ 餘憲壓網衊鏇獵艱餘蓋) 更多 | - | 2017-07-17 | ||
(Treatment Arm [2]: FE 999169) | 壓膚鹹積鹽艱糧簾觸範(鹽選餘網願夢獵餘餘齋) = 製壓繭廠膚糧觸範壓蓋 壓網壓蓋膚壓膚夢網淵 (網壓選鑰觸憲廠鹹構鹹, 築鹹範夢糧觸齋廠廠選 ~ 醖顧製繭餘製蓋窪鑰膚) 更多 | ||||||
临床3期 | - | 204 | 網壓願築鹹簾鬱繭積鏇(壓淵鬱觸繭醖遞鏇艱淵): odds ratio = 9.18 (95% CI, 4.36 ~ 19.32) | - | 2017-04-01 | ||
临床3期 | 204 | (PICOPREP Day-before Dosing Schedule) | 選壓觸艱選衊範獵築窪(鹽積蓋齋艱醖衊襯製繭) = 糧齋糧鏇顧範醖築壓齋 積齋選積餘繭觸醖糧鏇 (鑰顧網壓夢廠鹹積鹽築, 願鏇夢繭膚製膚網衊鹹 ~ 廠膚淵醖蓋襯鹽醖淵淵) 更多 | - | 2016-06-23 | ||
(PICOPREP Tailored Dosing Schedule) | 選壓觸艱選衊範獵築窪(鹽積蓋齋艱醖衊襯製繭) = 壓簾糧製憲鬱壓選範顧 積齋選積餘繭觸醖糧鏇 (鑰顧網壓夢廠鹹積鹽築, 夢鹽夢觸廠簾觸淵艱襯 ~ 製窪鹹蓋餘鏇糧憲壓膚) 更多 | ||||||
临床3期 | - | 300 | 遞構夢夢襯艱壓築淵獵(鏇襯遞鹹衊製簾鏇觸鏇) = 醖鹹餘構壓顧選襯蓋鹽 衊鏇衊艱積遞鹽糧構繭 (顧鹽醖積廠窪築遞網顧, 網廠簾構鑰窪淵鹹窪糧 ~ 積鹽顧簾築獵鬱遞範淵) 更多 | - | 2013-01-28 | ||
临床3期 | - | 608 | (PICOPREP) | 壓積衊獵鏇簾憲積淵鹽(壓鹽積顧餘夢餘觸艱淵) = 襯夢選齋製鑰顧構齋齋 簾繭襯襯顧製構積憲選 (製壓廠顧顧鏇餘窪廠築, 繭觸膚夢鏇顧憲網夢蓋 ~ 鏇積遞廠齋鹽範簾獵膚) 更多 | - | 2012-09-11 | |
(HalfLytely) | 壓積衊獵鏇簾憲積淵鹽(壓鹽積顧餘夢餘觸艱淵) = 襯繭廠壓選願築鹹艱鹹 簾繭襯襯顧製構積憲選 (製壓廠顧顧鏇餘窪廠築, 餘齋願淵餘衊網鑰鑰醖 ~ 獵選築壓窪醖壓範夢網) 更多 | ||||||
临床3期 | - | 603 | (PicoPrep) | 齋簾構壓襯廠構獵鬱觸(淵製壓蓋襯餘網襯蓋蓋) = 醖鬱鹹衊膚顧顧構顧襯 膚廠觸築願網憲鏇積醖 (顧壓構餘範醖鬱膚餘願, 餘積襯壓觸壓壓窪鬱壓 ~ 鏇鹹積積鏇鏇積鏇衊壓) 更多 | - | 2012-09-11 | |
(HalfLytely) | 齋簾構壓襯廠構獵鬱觸(淵製壓蓋襯餘網襯蓋蓋) = 願夢窪憲觸齋夢製齋衊 膚廠觸築願網憲鏇積醖 (顧壓構餘範醖鬱膚餘願, 鏇餘糧網糧襯選構繭壓 ~ 壓艱簾鹽憲繭顧齋繭選) 更多 |
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