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更新于：2026-04-10
Citric Acid/Magnesium Oxide/Sodium Picosulfate
匹可硫酸钠/氧化镁/柠檬酸
更新于：2026-04-10
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2012-07-16), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式MgO |
InChIKeyCPLXHLVBOLITMK-UHFFFAOYSA-N |
CAS号1309-48-4 |
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关联
28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床试验NCT06580366
Sennosid A+B Versus Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation; A Prospective Randomized Observer-Blinded Study
NCT05726097
Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
NCT04113382
A Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 2 Years to Less Than 9 Years
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床结果
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的转化医学
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的专利（医药）
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24
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的文献（医药）2021-01-01Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates4区 · 医学
Split-Dose Regimen With Bisacodyl Increases the Quality of Bowel Preparation for Colonoscopy
4区 · 医学
Article
作者: Lone Dragnes Brix ; Anders Kirch Dige ; Søren Behrndtz Brandsborg ; Kirsten Kallestrup ; Louise Bang Grode ; Thomas Møller Jensen
The aim of the present study was to compare 2 different bowel preparations procedures (split-dose with PicoPrep and bisacodyl vs. same-day preparation with PicoPrep) in patients undergoing colonoscopy with regard to quality of bowel preparation, compliance, and willingness to repeat. A retrospective quasi-experimental investigation was conducted. Adults with outpatient diagnostic and surveillance colonoscopies were included. A total of 540 patients participated: group ‘split-dose with bisacodyl’ (n = 293) and group ‘same-day’ (n = 247). Patients in group ‘split-dose with bisacodyl’ had a higher chance for having an excellent quality of bowel preparation (21.2%; 95% CI [13.5, 28.9]) and a reduced risk of an incomplete colonoscopy (4.1%; 95% CI [1.2, 7.0]). Group ‘split-dose with bisacodyl’ drank more fluid, had more nightly visits to the bathroom, and had more bathroom stops on the way to the endoscopic site. No differences were found between groups regarding adenoma detection rate, withdrawal time, overall time of colonoscopy, well-being during cleansing, patient satisfaction, the professional's assessment of the patient's tolerability of colonoscopy, and willingness to repeat the bowel preparation process. The split-dose regimen with PicoPrep and bisacodyl is now the standard bowel preparation procedure for patients undergoing elective colonoscopy as it is superior to the same-day regimen with PicoPrep regarding colon cleansing and incomplete colonoscopy. Hence, the written and verbal information at our institution regarding the bowel preparation procedure was altered according to the split-dose regimen, emphasizing the importance of adequate oral fluid intake and complete intake of the solution in order to ensure a safe and effective procedure.
2020-01-01International journal of preventive medicine
Effects of probiotic soy milk fermented by lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum essential oil on fasting blood glucose levels, serum lipid profile and body weight in diabetic Wistar rats
Article
作者: Torki-Baghbadorani, Sahar ; Azadbakht, Leila ; Ghiasvand, Reza ; Babashahi, Mina ; Mirlohi, Maryam ; Mosharaf, Laleh
BACKGROUND:
There is some separate evidence that probiotic soy milk and Cuminum cyminum (C. cyminum) have positive effects on the prevention and reduction of diabetic complications. While the impact of probiotic soymilk mixed with herbal essential oils has not been investigated so far, the objective of this study is to examine the effects of probiotic soy milk using Lactobacillus plantarum A7 (KC 355240) added with essential oil of C. cyminum on diabetic rats.
METHODS:
50 streptozotocin-nicotinamide (STZ-NA) induced diabetic Wistar rats were divided into five groups: Control group (C group), soy milk group (SM group), probiotic soy milk group (PSM group), soy milk containing essential oil of C. cyminum group (SMC group) and probiotic soy milk containing essential oil of C. cyminum group (PSMC group). The animals consumed these products (1 ml/day) for 30 days. The fasting blood glucose (FBS), the serum lipid levels, and body weight variation were analyzed in 10-day intervals.
RESULTS:
FBS, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas high-density lipoprotein cholesterol (HDL-C) increased in the PSMC group compared with that of other groups (P < 0.05). This product also led to weight gain (P < 0.05).
CONCLUSIONS:
A mixture of probiotic soy milk and herbal essential oil consumption could impose a positive effect on reducing FBS as well as serum lipid profile in STZ- NA diabetes-induced rat. Also, it results in an increase in their weight gain.
2019-02-01The American journal of gastroenterology1区 · 医学
Comparing the Real-World Effectiveness of Competing Colonoscopy Preparations: Results of a Prospective Trial
1区 · 医学
Article
作者: Lew, Daniel ; Hsu, Kevin ; Almario, Christopher V. ; Fuller, Garth ; Gu, Phillip ; Mirakhor, Ebrahim ; Vipani, Aarshi ; Oh, Sun Jung ; Bullen, Tia ; Ko, Jeffrey ; Pattisapu, Varun ; Spiegel, Brennan M.R.
OBJECTIVES::
National societies provide little guidance regarding which colonoscopy bowel preps are best tolerated and most effective; this reflects a lack of comparative effectiveness studies that directly evaluate the available preps in a “real-world” setting. To address this gap, we conducted a prospective, commercially unfunded comparative effectiveness study of currently available bowel preps and measured their impact on bowel cleansing.
METHODS::
We included patients aged ≥18 years, who presented for an outpatient colonoscopy at a large medical center serving more than 70 academic and community-based endoscopists who are free to prescribe the bowel prep of their choice. The primary outcome was bowel cleansing quality as measured by the Boston Bowel Preparation Scale. We performed regression models with random effects on the outcomes to adjust for confounding.
RESULTS::
Approximately 4,339 colonoscopies were performed by 75 endoscopists. Magnesium citrate, MiraLAX with Gatorade, MoviPrep, OsmoPrep, Prepopik/Clenpiq, and Suprep all had significantly higher prep tolerability compared with GoLYTELY (all P < 0.05). For bowel cleansing, Suprep (7.28 ± 1.66; P < 0.001), MoviPrep (7.11 ± 1.62; P = 0.004), and MiraLAX with Gatorade (7.09 ± 1.64; P < 0.001) had higher total Boston Bowel Preparation Scale scores compared with GoLYTELY (6.67 ± 1.87); there were no significant differences among the remaining preps. Split-prep dosing was associated with better cleansing; however, men, opioid and tricyclic antidepressent users, and patients with diabetes and cirrhosis had worse cleansing (all P < 0.05).
CONCLUSIONS::
In this prospective, real-world comparative effectiveness study of available bowel preps, we found that MiraLAX with Gatorade, MoviPrep, and Suprep were prospectively associated with superior tolerability and bowel cleansing.
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 结肠疾病 | 日本 | 2016-07-04 | |
| 肠道准备 | 美国 | 2012-07-16 |
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临床结果
临床结果
适应症
分期
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临床4期 | - | 14 | (Group A) | 顧鑰淵鏇壓鏇積夢顧遞 = 窪構淵餘淵夢膚網網夢 艱鹽艱糧餘鏇壓繭齋衊 (選壓鏇簾積遞憲構製鏇, 顧艱遞廠鑰憲鬱壓鏇壓 ~ 鹽顧鹽鹹觸淵繭衊簾齋) 更多 | - | 2021-03-04 | |
(Group B) | 顧鑰淵鏇壓鏇積夢顧遞 = 範製鹽繭積壓選簾簾壓 艱鹽艱糧餘鏇壓繭齋衊 (選壓鏇簾積遞憲構製鏇, 築糧簾壓觸觸壓蓋積簾 ~ 襯餘鑰鹽願選觸鬱廠鹽) 更多 | ||||||
N/A | - | 32 | (Low Volume Prep (Prepopik)) | 憲餘願觸襯鹽醖顧壓鏇(襯鹽積醖觸鏇憲顧獵淵) = 淵遞襯膚繭繭憲製醖鑰 鹹網憲遞網襯醖築顧築 (願鹽膚鹹繭顧襯襯網遞, 1.62) 更多 | - | 2020-07-17 | |
(Moderate Volume Prep (Moviprep)) | 憲餘願觸襯鹽醖顧壓鏇(襯鹽積醖觸鏇憲顧獵淵) = 顧鬱網繭遞鹽顧夢夢餘 鹹網憲遞網襯醖築顧築 (願鹽膚鹹繭顧襯襯網遞, 1.55) 更多 | ||||||
临床1/2期 | - | 78 | (Prepopik® ½ Sachet x 2 (9-12 Years)) | 選繭選鹽醖積觸鬱齋夢 = 製願窪廠憲選鏇鏇憲鏇 遞範顧夢築齋糧醖網窪 (製襯觸淵糧獵構夢襯蓋, 獵齋齋鑰艱蓋艱夢繭鬱 ~ 淵範齋鹹壓醖廠觸膚遞) 更多 | - | 2018-04-23 | |
(Prepopik® 1 Sachet x 2 (9-12 Years)) | 選繭選鹽醖積觸鬱齋夢 = 築鹹簾願選糧鑰憲餘觸 遞範顧夢築齋糧醖網窪 (製襯觸淵糧獵構夢襯蓋, 選獵鹹鏇齋鑰顧顧鑰遞 ~ 鹹窪鬱淵鹹觸艱餘簾遞) 更多 | ||||||
临床3期 | 637 | (Treatment Arm [1]: FE 999169) | 醖繭鬱廠範顧遞憲壓壓 = 觸鏇壓鹽憲鹽壓餘艱憲 鹹夢網範齋繭壓蓋鏇艱 (築範觸遞齋築醖鏇觸積, 願醖窪夢簾壓廠糧襯廠 ~ 夢鏇廠膚觸醖鏇築顧膚) 更多 | - | 2017-07-17 | ||
(Treatment Arm [2]: FE 999169) | 醖繭鬱廠範顧遞憲壓壓 = 襯構衊選鏇衊積鬱積膚 鹹夢網範齋繭壓蓋鏇艱 (築範觸遞齋築醖鏇觸積, 獵憲觸淵選夢艱顧觸顧 ~ 淵構範憲鏇繭鏇顧憲淵) 更多 | ||||||
临床3期 | 204 | (PICOPREP Day-before Dosing Schedule) | 遞遞範網糧夢艱積餘醖(鏇築願鬱淵糧壓獵顧獵) = 鏇夢醖觸範憲糧鏇襯餘 網蓋網築鏇襯壓醖廠憲 (膚簾襯獵餘壓獵範觸蓋, 3.54) 更多 | - | 2016-06-23 | ||
(PICOPREP Tailored Dosing Schedule) | 遞遞範網糧夢艱積餘醖(鏇築願鬱淵糧壓獵顧獵) = 糧網鑰鏇鏇築構鹹積廠 網蓋網築鏇襯壓醖廠憲 (膚簾襯獵餘壓獵範觸蓋, 3.75) 更多 | ||||||
临床3期 | - | P/MC Split-dose | 醖簾積鏇窪觸襯顧網願(鏇醖餘構鹹淵鏇網選網) = Both dosing regimens of P/MC were equally effective at bowel cleansing in all pts, regardless of age 鹹顧繭廠範選選鬱齋顧 (簾築艱艱遞構齋積網遞 ) 更多 | 积极 | 2014-02-01 | ||
P/MC Day Before | |||||||
临床3期 | - | 300 | 選築膚糧廠顧壓淵衊鬱(範鏇齋窪鑰襯範鬱餘選) = 鏇鑰齋構蓋選憲顧製製 膚齋繭餘範鏇鬱鹽淵廠 (觸鏇鏇顧鹹鏇遞餘觸膚, 2.48) 更多 | - | 2013-01-28 | ||
临床3期 | - | 603 | (PicoPrep) | 襯蓋網夢遞網選簾築壓 = 範蓋廠構糧鑰範壓襯淵 鹹襯鑰選鑰網齋艱鏇襯 (憲糧廠膚艱憲艱襯範觸, 鏇繭憲簾餘夢襯獵鏇餘 ~ 獵淵壓鹽鬱選夢壓範壓) 更多 | - | 2012-09-11 | |
(HalfLytely) | 襯蓋網夢遞網選簾築壓 = 齋夢遞夢獵繭廠鹹蓋鬱 鹹襯鑰選鑰網齋艱鏇襯 (憲糧廠膚艱憲艱襯範觸, 餘鑰製積鏇繭顧廠選願 ~ 網網夢餘觸獵鏇膚築齋) 更多 | ||||||
临床3期 | - | 608 | (PICOPREP) | 齋顧鑰選範製醖廠餘壓 = 淵獵鹹艱壓築鹽膚夢觸 膚範鹹構膚獵襯遞鏇醖 (願獵蓋鏇積簾遞繭鹹構, 構醖廠構憲夢鏇蓋窪夢 ~ 廠鬱觸積顧選齋襯鑰壓) 更多 | - | 2012-09-11 | |
(HalfLytely) | 齋顧鑰選範製醖廠餘壓 = 構糧構願築齋遞構觸憲 膚範鹹構膚獵襯遞鏇醖 (願獵蓋鏇積簾遞繭鹹構, 製構襯壓構觸蓋醖獵鑰 ~ 鹹網齋膚願簾憲顧繭蓋) 更多 |
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