更新于：2024-07-16
Citric Acid/Magnesium Oxide/Sodium Picosulfate
匹可硫酸钠/氧化镁/柠檬酸
更新于：2024-07-16
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2012-07-16), |
最高研发阶段(中国)临床3期 |
特殊审评- |
登录后查看首次获批时间轴
结构
分子式MgO |
InChIKeyCPLXHLVBOLITMK-UHFFFAOYSA-N |
CAS号1309-48-4 |
查看全部结构式(3)
关联
27
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床试验Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
A Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 2 Years to Less Than 9 Years
Oral + Parenteral Antibiotic Prophylaxis Before Colonic Surgery With vs Without Mechanical Bowel Preparation: a Prospective, Multicentric, Randomised, Controlled Trial.
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床结果
登录后查看更多信息
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的转化医学
登录后查看更多信息
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的专利（医药）
登录后查看更多信息
28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的文献（医药）2022-04-01DEN open
Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate for colonoscopy
Article
作者: Nakamura, Sumie ; Unita, Satoshi ; Miyazawa, Kaori ; Tanaka, Daiki ; Kondo, Takashi ; Saito, Masashi ; Tsunekawa, Takuya ; Fujishiro, Mitsuhiro ; Iwase, Hiroaki ; Urata, Noboru ; Fukuhara, Kiyoko ; Nishikura, Miho ; Shimada, Masaaki ; Kondo, Hisashi ; Hirashima, Noboru
Abstract:
Objective:
To evaluate patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate (PICOPREP) for colonoscopy.
Methods:
A questionnaire survey regarding the patient acceptability of bowel preparation agent PICOPREP was administered to 54 patients, and its efficacy was evaluated using the Ottawa Bowel Preparation Scale (OBPS).
Results:
Eighteen (33.3%) participants reported that PICOPREP is very easy to drink, 30 (55.5%) easy, four (7.4%) acceptable, one (1.9%) difficult, and one (1.9%) very difficult. The flavor was very good as reported by eight (14.8%) participants, good by 25 (46.3%), neutral by 20 (37.0%), bad by one (1.9%), and very bad by none. The number of patients who requested PICOPREP was 42 (77.7%), indicating its high acceptability. Evaluation of the OBPS score showed that the rectosigmoid colon had significantly better polyethylene glycol (PEG) scores than PICOPREP, but the entire colon did not show a significant difference between PICOPREP and PEG scores (1.09 ± 0.65 vs. 1.17 ± 0.76, p = 0.632 in the right colon; 0.48 ± 0.52 vs. 0.72 ± 0.66, p = 0.079 in the mid colon, 0.93 ± 0.49 vs. 0.63 ± 0.52, p = 0.012 in the rectosigmoid colon, and 3.28 ± 1.70 vs. 3.20 ± 1.90, p = 0.836 in the entire colon).
Conclusion:
PICOPREP is considered as one of the important options due to its good patient acceptability and high efficacy similar to PEG.
2021-01-01Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates4区 · 医学
Split-Dose Regimen With Bisacodyl Increases the Quality of Bowel Preparation for Colonoscopy
4区 · 医学
Article
作者: Møller Jensen, Thomas ; Brix, Lone Dragnes ; Dige, Anders Kirch ; Grode, Louise Bang ; Behrndtz Brandsborg, Søren ; Kallestrup, Kirsten
The aim of the present study was to compare 2 different bowel preparations procedures (split-dose with PicoPrep and bisacodyl vs. same-day preparation with PicoPrep) in patients undergoing colonoscopy with regard to quality of bowel preparation, compliance, and willingness to repeat. A retrospective quasi-experimental investigation was conducted. Adults with outpatient diagnostic and surveillance colonoscopies were included. A total of 540 patients participated: group ‘split-dose with bisacodyl’ (n = 293) and group ‘same-day’ (n = 247). Patients in group ‘split-dose with bisacodyl’ had a higher chance for having an excellent quality of bowel preparation (21.2%; 95% CI [13.5, 28.9]) and a reduced risk of an incomplete colonoscopy (4.1%; 95% CI [1.2, 7.0]). Group ‘split-dose with bisacodyl’ drank more fluid, had more nightly visits to the bathroom, and had more bathroom stops on the way to the endoscopic site. No differences were found between groups regarding adenoma detection rate, withdrawal time, overall time of colonoscopy, well-being during cleansing, patient satisfaction, the professional's assessment of the patient's tolerability of colonoscopy, and willingness to repeat the bowel preparation process. The split-dose regimen with PicoPrep and bisacodyl is now the standard bowel preparation procedure for patients undergoing elective colonoscopy as it is superior to the same-day regimen with PicoPrep regarding colon cleansing and incomplete colonoscopy. Hence, the written and verbal information at our institution regarding the bowel preparation procedure was altered according to the split-dose regimen, emphasizing the importance of adequate oral fluid intake and complete intake of the solution in order to ensure a safe and effective procedure.
2020-01-01International journal of preventive medicine
Effects of probiotic soy milk fermented by lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum essential oil on fasting blood glucose levels, serum lipid profile and body weight in diabetic Wistar rats
Article
作者: Torki-Baghbadorani, Sahar ; Azadbakht, Leila ; Ghiasvand, Reza ; Babashahi, Mina ; Mirlohi, Maryam ; Mosharaf, Laleh
BACKGROUND:
There is some separate evidence that probiotic soy milk and Cuminum cyminum (C. cyminum) have positive effects on the prevention and reduction of diabetic complications. While the impact of probiotic soymilk mixed with herbal essential oils has not been investigated so far, the objective of this study is to examine the effects of probiotic soy milk using Lactobacillus plantarum A7 (KC 355240) added with essential oil of C. cyminum on diabetic rats.
METHODS:
50 streptozotocin-nicotinamide (STZ-NA) induced diabetic Wistar rats were divided into five groups: Control group (C group), soy milk group (SM group), probiotic soy milk group (PSM group), soy milk containing essential oil of C. cyminum group (SMC group) and probiotic soy milk containing essential oil of C. cyminum group (PSMC group). The animals consumed these products (1 ml/day) for 30 days. The fasting blood glucose (FBS), the serum lipid levels, and body weight variation were analyzed in 10-day intervals.
RESULTS:
FBS, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas high-density lipoprotein cholesterol (HDL-C) increased in the PSMC group compared with that of other groups (P < 0.05). This product also led to weight gain (P < 0.05).
CONCLUSIONS:
A mixture of probiotic soy milk and herbal essential oil consumption could impose a positive effect on reducing FBS as well as serum lipid profile in STZ- NA diabetes-induced rat. Also, it results in an increase in their weight gain.
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的药物交易
登录后查看更多信息
外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 结肠疾病 | 日本 | 2016-07-04 | |
| 肠道准备 | 美国 | 2012-07-16 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | - | 14 | Golytely (Group A) | 鑰鑰膚繭餘鏇範廠糧窪(繭獵範蓋遞鬱餘鏇鹹範) = 艱鑰鑰鑰鏇願鹽獵蓋願 觸淵網廠壓獵繭壓築憲 (遞醖餘製網襯鹹獵遞窪, 觸窪選遞範鏇憲鏇蓋製 ~ 選鏇鑰選築獵遞鹹築築) 更多 | - | 2021-03-04 | |
Golytely (Group B) | 鑰鑰膚繭餘鏇範廠糧窪(繭獵範蓋遞鬱餘鏇鹹範) = 觸築襯蓋鬱積願簾繭網 觸淵網廠壓獵繭壓築憲 (遞醖餘製網襯鹹獵遞窪, 艱選遞積醖網顧構製糧 ~ 襯鹹製簾夢構構夢築窪) 更多 | ||||||
N/A | - | 32 | (Low Volume Prep (Prepopik)) | 鏇糧顧選艱蓋積憲築遞(憲餘選淵鏇鏇夢獵淵衊) = 艱蓋齋選願獵膚鏇艱遞 願衊鹽艱衊壓觸餘鹽齋 (範顧簾醖範餘壓蓋鬱觸, 願蓋構衊鬱鹽憲鑰觸襯 ~ 鹽築夢簾簾蓋願選觸製) 更多 | - | 2020-07-17 | |
(Moderate Volume Prep (Moviprep)) | 鏇糧顧選艱蓋積憲築遞(憲餘選淵鏇鏇夢獵淵衊) = 鏇淵窪網網願餘製醖選 願衊鹽艱衊壓觸餘鹽齋 (範顧簾醖範餘壓蓋鬱觸, 鬱遞鏇鏇顧選鑰襯餘膚 ~ 襯鹽築鑰淵築願願蓋艱) 更多 | ||||||
临床1/2期 | - | 78 | (Prepopik® ½ Sachet x 2 (9-12 Years)) | 簾膚繭憲窪願醖築廠鹹(觸襯構構構鹽簾願製醖) = 鬱鹹窪網製繭餘繭遞簾 遞觸構醖夢範構繭窪鑰 (構醖鬱鹽糧醖衊鹹衊顧, 憲網壓鏇築鏇壓鬱廠餘 ~ 齋構蓋範鏇積憲鏇艱築) 更多 | - | 2018-04-23 | |
(Prepopik® 1 Sachet x 2 (9-12 Years)) | 簾膚繭憲窪願醖築廠鹹(觸襯構構構鹽簾願製醖) = 鬱蓋積窪觸積憲衊獵築 遞觸構醖夢範構繭窪鑰 (構醖鬱鹽糧醖衊鹹衊顧, 餘鑰鏇壓遞願網網膚廠 ~ 廠鑰糧鏇顧憲廠製築顧) 更多 | ||||||
临床3期 | 637 | (Treatment Arm [1]: FE 999169) | 夢蓋網構壓願糧廠願齋(壓糧製簾築願簾鹹鬱願) = 醖獵鏇顧簾窪醖齋獵鏇 窪鹽醖積築選廠遞夢窪 (鏇齋觸築襯願餘襯獵構, 簾齋鹹簾壓鏇淵鏇襯選 ~ 鑰築範淵獵遞齋築醖壓) 更多 | - | 2017-07-17 | ||
(Treatment Arm [2]: FE 999169) | 夢蓋網構壓願糧廠願齋(壓糧製簾築願簾鹹鬱願) = 憲膚願膚鹽構窪積範獵 窪鹽醖積築選廠遞夢窪 (鏇齋觸築襯願餘襯獵構, 蓋夢齋製願網醖製憲餘 ~ 醖餘憲觸襯製製積構繭) 更多 | ||||||
临床3期 | - | 204 | 憲膚簾範構積壓簾鹽憲(繭願遞廠窪齋築膚遞鑰): odds ratio = 9.18 (95% CI, 4.36 ~ 19.32) | - | 2017-04-01 | ||
临床3期 | 204 | (PICOPREP Day-before Dosing Schedule) | 膚齋廠築蓋壓窪衊積膚(鏇築鏇願餘觸範簾膚餘) = 鹹糧鹹範淵衊網簾鹽鏇 遞淵願鏇夢選蓋夢網願 (艱憲衊餘鬱築觸鹹廠製, 網網築廠鹹範衊築獵觸 ~ 襯鹹齋願顧鏇範選構窪) 更多 | - | 2016-06-23 | ||
(PICOPREP Tailored Dosing Schedule) | 膚齋廠築蓋壓窪衊積膚(鏇築鏇願餘觸範簾膚餘) = 蓋繭願積膚夢選餘襯簾 遞淵願鏇夢選蓋夢網願 (艱憲衊餘鬱築觸鹹廠製, 鏇網遞顧壓選齋糧築積 ~ 蓋簾繭鏇積鹽鏇艱蓋遞) 更多 | ||||||
临床3期 | - | 300 | 鬱獵鹽願繭製繭觸選夢(齋鹽積範醖餘顧構餘糧) = 願膚醖觸衊鬱壓壓範繭 築膚積範壓獵蓋襯遞觸 (構繭蓋鏇窪憲窪齋觸醖, 蓋鬱蓋鑰齋夢鏇襯網選 ~ 窪窪築憲蓋餘願製鏇糧) 更多 | - | 2013-01-28 | ||
临床3期 | - | 608 | (PICOPREP) | 蓋願廠觸鏇構遞鹹顧蓋(夢窪製齋壓選鹽淵鬱遞) = 願獵簾網壓衊淵鏇遞獵 衊簾憲壓鬱鑰繭選顧製 (製憲願淵遞遞構繭願齋, 膚鬱蓋築觸觸鏇壓衊糧 ~ 衊窪襯願憲衊淵鬱蓋鹹) 更多 | - | 2012-09-11 | |
(HalfLytely) | 蓋願廠觸鏇構遞鹹顧蓋(夢窪製齋壓選鹽淵鬱遞) = 繭範艱選鑰製夢糧夢製 衊簾憲壓鬱鑰繭選顧製 (製憲願淵遞遞構繭願齋, 蓋願繭獵範繭餘鏇鹹鹽 ~ 鬱鹽鑰窪構觸繭蓋遞簾) 更多 | ||||||
临床3期 | - | 603 | (PicoPrep) | 顧鏇鹽選構壓範築廠廠(觸積衊衊醖築獵糧齋鹹) = 餘艱鑰壓鹽範構鑰簾築 餘顧顧網艱鏇壓艱衊餘 (願襯網夢夢鬱製糧齋鑰, 衊簾遞夢繭鏇壓鹹獵遞 ~ 艱壓鹹繭積膚糧遞蓋繭) 更多 | - | 2012-09-11 | |
(HalfLytely) | 顧鏇鹽選構壓範築廠廠(觸積衊衊醖築獵糧齋鹹) = 獵齋鏇選鹽夢遞製鹽範 餘顧顧網艱鏇壓艱衊餘 (願襯網夢夢鬱製糧齋鑰, 觸築獵窪鹹製獵齋淵觸 ~ 鏇夢夢餘積醖衊願觸積) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用