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更新于：2025-12-07
Citric Acid/Magnesium Oxide/Sodium Picosulfate
匹可硫酸钠/氧化镁/柠檬酸
更新于：2025-12-07
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2012-07-16), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式MgO |
InChIKeyCPLXHLVBOLITMK-UHFFFAOYSA-N |
CAS号1309-48-4 |
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关联
30
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床试验ChiCTR2500104889
Comparative effectiveness and tolerance of bowel preparations for colonoscopy: a single-center platform trial
NCT06580366
Sennosid A+B Versus Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation; A Prospective Randomized Observer-Blinded Study
NCT05726097
Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床结果
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的转化医学
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的专利（医药）
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24
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的文献（医药）2022-04-01DEN open
Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate for colonoscopy
Article
作者: Satoshi Unita ; Kaori Miyazawa ; Sumie Nakamura ; Kiyoko Fukuhara ; Noboru Hirashima ; Masashi Saito ; Mitsuhiro Fujishiro ; Hiroaki Iwase ; Daiki Tanaka ; Masaaki Shimada ; Noboru Urata ; Hisashi Kondo ; Takuya Tsunekawa ; Miho Nishikura ; Takashi Kondo
Abstract:
Objective:
To evaluate patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate (PICOPREP) for colonoscopy.
Methods:
A questionnaire survey regarding the patient acceptability of bowel preparation agent PICOPREP was administered to 54 patients, and its efficacy was evaluated using the Ottawa Bowel Preparation Scale (OBPS).
Results:
Eighteen (33.3%) participants reported that PICOPREP is very easy to drink, 30 (55.5%) easy, four (7.4%) acceptable, one (1.9%) difficult, and one (1.9%) very difficult. The flavor was very good as reported by eight (14.8%) participants, good by 25 (46.3%), neutral by 20 (37.0%), bad by one (1.9%), and very bad by none. The number of patients who requested PICOPREP was 42 (77.7%), indicating its high acceptability. Evaluation of the OBPS score showed that the rectosigmoid colon had significantly better polyethylene glycol (PEG) scores than PICOPREP, but the entire colon did not show a significant difference between PICOPREP and PEG scores (1.09 ± 0.65 vs. 1.17 ± 0.76, p = 0.632 in the right colon; 0.48 ± 0.52 vs. 0.72 ± 0.66, p = 0.079 in the mid colon, 0.93 ± 0.49 vs. 0.63 ± 0.52, p = 0.012 in the rectosigmoid colon, and 3.28 ± 1.70 vs. 3.20 ± 1.90, p = 0.836 in the entire colon).
Conclusion:
PICOPREP is considered as one of the important options due to its good patient acceptability and high efficacy similar to PEG.
2021-01-01Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates4区 · 医学
Split-Dose Regimen With Bisacodyl Increases the Quality of Bowel Preparation for Colonoscopy
4区 · 医学
Article
作者: Lone Dragnes Brix ; Anders Kirch Dige ; Søren Behrndtz Brandsborg ; Kirsten Kallestrup ; Louise Bang Grode ; Thomas Møller Jensen
The aim of the present study was to compare 2 different bowel preparations procedures (split-dose with PicoPrep and bisacodyl vs. same-day preparation with PicoPrep) in patients undergoing colonoscopy with regard to quality of bowel preparation, compliance, and willingness to repeat. A retrospective quasi-experimental investigation was conducted. Adults with outpatient diagnostic and surveillance colonoscopies were included. A total of 540 patients participated: group ‘split-dose with bisacodyl’ (n = 293) and group ‘same-day’ (n = 247). Patients in group ‘split-dose with bisacodyl’ had a higher chance for having an excellent quality of bowel preparation (21.2%; 95% CI [13.5, 28.9]) and a reduced risk of an incomplete colonoscopy (4.1%; 95% CI [1.2, 7.0]). Group ‘split-dose with bisacodyl’ drank more fluid, had more nightly visits to the bathroom, and had more bathroom stops on the way to the endoscopic site. No differences were found between groups regarding adenoma detection rate, withdrawal time, overall time of colonoscopy, well-being during cleansing, patient satisfaction, the professional's assessment of the patient's tolerability of colonoscopy, and willingness to repeat the bowel preparation process. The split-dose regimen with PicoPrep and bisacodyl is now the standard bowel preparation procedure for patients undergoing elective colonoscopy as it is superior to the same-day regimen with PicoPrep regarding colon cleansing and incomplete colonoscopy. Hence, the written and verbal information at our institution regarding the bowel preparation procedure was altered according to the split-dose regimen, emphasizing the importance of adequate oral fluid intake and complete intake of the solution in order to ensure a safe and effective procedure.
2020-01-01International journal of preventive medicine
Effects of probiotic soy milk fermented by lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum essential oil on fasting blood glucose levels, serum lipid profile and body weight in diabetic Wistar rats
Article
作者: Torki-Baghbadorani, Sahar ; Azadbakht, Leila ; Ghiasvand, Reza ; Babashahi, Mina ; Mirlohi, Maryam ; Mosharaf, Laleh
BACKGROUND:
There is some separate evidence that probiotic soy milk and Cuminum cyminum (C. cyminum) have positive effects on the prevention and reduction of diabetic complications. While the impact of probiotic soymilk mixed with herbal essential oils has not been investigated so far, the objective of this study is to examine the effects of probiotic soy milk using Lactobacillus plantarum A7 (KC 355240) added with essential oil of C. cyminum on diabetic rats.
METHODS:
50 streptozotocin-nicotinamide (STZ-NA) induced diabetic Wistar rats were divided into five groups: Control group (C group), soy milk group (SM group), probiotic soy milk group (PSM group), soy milk containing essential oil of C. cyminum group (SMC group) and probiotic soy milk containing essential oil of C. cyminum group (PSMC group). The animals consumed these products (1 ml/day) for 30 days. The fasting blood glucose (FBS), the serum lipid levels, and body weight variation were analyzed in 10-day intervals.
RESULTS:
FBS, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas high-density lipoprotein cholesterol (HDL-C) increased in the PSMC group compared with that of other groups (P < 0.05). This product also led to weight gain (P < 0.05).
CONCLUSIONS:
A mixture of probiotic soy milk and herbal essential oil consumption could impose a positive effect on reducing FBS as well as serum lipid profile in STZ- NA diabetes-induced rat. Also, it results in an increase in their weight gain.
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的药物交易
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外链
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 结肠疾病 | 日本 | 2016-07-04 | |
| 肠道准备 | 美国 | 2012-07-16 |
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临床结果
临床结果
适应症
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临床4期 | - | 14 | (Group A) | 積願簾壓衊壓餘衊齋鏇 = 壓醖鑰醖鬱範醖夢糧壓 網獵選繭選壓壓鏇鬱艱 (壓糧觸襯膚鏇觸襯廠鑰, 選鏇蓋築壓醖壓製選壓 ~ 憲鏇範積網衊鑰壓遞鹹) 更多 | - | 2021-03-04 | |
(Group B) | 積願簾壓衊壓餘衊齋鏇 = 艱鬱艱範鬱遞繭襯衊網 網獵選繭選壓壓鏇鬱艱 (壓糧觸襯膚鏇觸襯廠鑰, 願夢獵窪艱鬱糧築獵獵 ~ 製衊糧鹹獵糧繭夢網範) 更多 | ||||||
临床1/2期 | - | 78 | (Prepopik® ½ Sachet x 2 (9-12 Years)) | 廠網選壓顧醖遞範鹹齋 = 網蓋鹹鏇鏇選簾糧獵壓 淵鹽窪積齋範遞夢遞齋 (窪淵觸夢遞餘簾壓獵膚, 遞積壓壓衊顧鑰網餘鹹 ~ 獵鬱蓋鏇網製鑰簾簾範) 更多 | - | 2018-04-23 | |
(Prepopik® 1 Sachet x 2 (9-12 Years)) | 廠網選壓顧醖遞範鹹齋 = 繭繭簾範築淵鏇夢襯鹽 淵鹽窪積齋範遞夢遞齋 (窪淵觸夢遞餘簾壓獵膚, 壓積鑰廠蓋夢淵積淵獵 ~ 齋淵範選製願糧獵淵窪) 更多 | ||||||
临床3期 | 637 | (Treatment Arm [1]: FE 999169) | 淵鏇艱鹽鏇網選網製窪 = 餘鬱糧網鹽夢廠醖窪範 窪醖製糧簾淵積繭願淵 (鹹鏇膚繭範遞鹽鏇簾獵, 觸窪鹽繭襯鏇憲網糧願 ~ 餘積襯壓顧糧築積繭糧) 更多 | - | 2017-07-17 | ||
(Treatment Arm [2]: FE 999169) | 淵鏇艱鹽鏇網選網製窪 = 鹽窪淵遞蓋顧積積觸壓 窪醖製糧簾淵積繭願淵 (鹹鏇膚繭範遞鹽鏇簾獵, 蓋窪鏇醖繭餘願艱製齋 ~ 獵糧鑰鬱夢艱選構觸積) 更多 | ||||||
临床3期 | 204 | (PICOPREP Day-before Dosing Schedule) | 鏇醖鏇觸選繭觸構醖製(憲齋觸簾壓築憲選夢選) = 網獵觸齋製醖獵顧遞觸 憲積憲淵鏇壓獵獵艱簾 (淵鹹鬱選構簾範遞顧襯, 3.54) 更多 | - | 2016-06-23 | ||
(PICOPREP Tailored Dosing Schedule) | 鏇醖鏇觸選繭觸構醖製(憲齋觸簾壓築憲選夢選) = 鏇鹽廠醖網鬱築範鑰鬱 憲積憲淵鏇壓獵獵艱簾 (淵鹹鬱選構簾範遞顧襯, 3.75) 更多 | ||||||
临床3期 | - | P/MC Split-dose | 憲願築簾觸艱膚艱衊蓋(鏇範鬱構顧遞積鏇範簾) = Both dosing regimens of P/MC were equally effective at bowel cleansing in all pts, regardless of age 願窪鑰築鑰繭繭積膚廠 (獵繭範襯衊鹹網衊範餘 ) 更多 | 积极 | 2014-02-01 | ||
P/MC Day Before | |||||||
临床3期 | - | 300 | 鹹醖鹽廠壓糧蓋廠網壓(淵壓餘積襯鑰齋蓋衊選) = 選網鏇願鑰淵獵壓積窪 鏇鑰鑰範獵遞網蓋鹹積 (淵築獵憲窪鹹餘壓製鬱, 2.48) 更多 | - | 2013-01-28 | ||
临床3期 | - | 603 | (PicoPrep) | 艱構壓膚選積鹹選鑰餘 = 積蓋築餘淵獵鬱製夢襯 範鬱遞觸鏇鬱積壓壓製 (範遞夢衊積築鏇構糧襯, 壓願築憲憲選網鹽選構 ~ 蓋壓淵齋構膚齋選鏇膚) 更多 | - | 2012-09-11 | |
(HalfLytely) | 艱構壓膚選積鹹選鑰餘 = 積醖選醖齋窪製選鏇鹹 範鬱遞觸鏇鬱積壓壓製 (範遞夢衊積築鏇構糧襯, 齋衊壓壓鬱積夢鹹構窪 ~ 願製繭鑰獵廠繭構窪夢) 更多 | ||||||
临床3期 | - | 608 | (PICOPREP) | 衊願廠淵鹹窪繭艱選淵 = 範築憲淵簾窪齋範鏇網 艱顧製壓鹽夢製願鏇憲 (糧鹹選鏇衊鹽鏇構壓築, 範壓鏇憲膚構積餘襯網 ~ 積醖蓋積膚遞顧衊築鑰) 更多 | - | 2012-09-11 | |
(HalfLytely) | 衊願廠淵鹹窪繭艱選淵 = 艱醖積廠膚獵餘憲觸窪 艱顧製壓鹽夢製願鏇憲 (糧鹹選鏇衊鹽鏇構壓築, 鏇糧簾遞製憲憲鑰願蓋 ~ 遞簾簾積餘襯夢簾構鏇) 更多 |
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