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更新于：2025-09-06
Calcium Acetate
醋酸钙
更新于：2025-09-06
概要
基本信息
药物类型 小分子化药 |
别名 Acetate of lime、Brown acetate of lime、Calcium acetate (USP) + [13] |
作用方式 调节剂 |
作用机制 Phosphates 调节剂(磷酸盐 调节剂) |
在研适应症- |
在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1990-12-10), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C4H8CaO4 |
InChIKeyWGTHSEQMDUDZLL-UHFFFAOYSA-N |
CAS号62-54-4 |
关联
16
项与 醋酸钙 相关的临床试验IRCT20160306026938N18
Investigation of the clinical effect of administering oral drops containing cinnamon, ginger and lime juice in obese patients (phase 2A)
CTR20230498
一项在健康受试者中评价含钙的磷结合剂醋酸钙片和非含钙的磷结合剂碳酸司维拉姆片对德度司他片的药动学影响的单中心、随机、开放、三周期交叉的I期临床研究
ChiCTR2300072509
A Single-site, Randomized, Open-label, Three-cycle-crossover Phase I Clinical Study to Evaluate the Pharmacokinetics of the Calcium-containing Phosphate Binder Calcium Acetate Tablets and the Non-calcium-containing Phosphate Binder Sevelamer Carbonate Tablets on Desidustat Tablets in Healthy Subjects
100 项与 醋酸钙 相关的临床结果
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100 项与 醋酸钙 相关的转化医学
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100 项与 醋酸钙 相关的专利（医药）
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159,446
项与 醋酸钙 相关的文献（医药）2025-12-31JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
2,5-Dihydroxyphenylethanone: an anti-melanogenic bioactive compound isolated from
Ganoderma cochlear
Article
作者: Ning, Meng ; Peng, Xing-Rong ; He, Min ; Liu, Xiao-Cui ; Qiu, Ming-Hua
2,5-dihydroxyacetophenone, a natural product from the fruiting bodies of Ganoderma cochlear, can effectively and safely inhibit the production of melanin in zebrafish model. To achieve analogues with more significant inhibition, 9 analogs were synthesised and 13 analogues were purchased commercially. Among them, 14 compounds can inhibit melanin production, of which 5 compounds displayed the most significant inhibitory effects, with inhibitory rates of more than 80%, compared to positive control SymWhite®377 (phenylethyl resorcinol). This study elucidated the melanin-inhibitory effects of 2,5-dihydroxyacetophenone and its analogs, providing a theoretical foundation for their potential applications in anti-melanogenic reagents.
2025-12-31Italian Journal of Animal Science
Preliminary evaluation of the effect of dietary supplementation of
Bacillus clausii
for adult healthy cats
作者: Ruggiero, Alessio ; Meineri, Giorgia ; Lonigro, Nicolò ; Vastolo, Alessandro ; Cutrignelli, Monica Isabella ; Adami, Raffaella
This study examines the influence of Bacillus clausii supplementation on feline nutrition, addressing the growing interest among pet owners in improving their pets' health and well-being through probiotics.As companion animals are increasingly regarded as members of the family, there is a growing emphasis on their dietary and health-related considerations.The objective of this study is to investigate the impact of Bacillus clausii, a strain with established antimicrobial and immunomodulatory properties, on the gut health of cats.A total of 14 neutered Chartreux cats were recruited for a double-blind trial.The cats were divided into two groups: a control group and a treatment group.The treatment group received Bacillus clausii supplements in their diet.Over 42 days, the body weight (BW), Body Condition Score (BCS) and faecal quality of the subjects were monitored.The results indicated a significant increase in feed intake in the treatment group in comparison to the control group, which suggests an improvement in digestive health.No significant differences in BW and BCS were discerned.Furthermore, the treatment group showed improved stool quality, reduced faecal scores and high dry matter content.IgA level increased in the faeces and reduced levels of calprotectin, a marker of intestinal inflammation, in the treatment group indicated better gut health.Bacillus clausii administration also resulted in an increase in short-chain fatty acids and butyrate, which promoted a beneficial microbial population.These preliminary results suggest that Bacillus clausii supplementation may improve gut health in cats, potentially leading to better health and well-being.
2025-12-31Italian Journal of Animal Science
Alpine pasture herbs redirected hydrogen towards alternative sinks, inhibiting methane production:
in vitro
study
作者: Dallavalle, Giulia ; Currò, Sarah ; Amalfitano, Nicolò ; Vrhovsek, Urska ; Angeli, Andrea ; Tagliapietra, Franco ; Nikolić, Nebojša ; Massaro, Selene ; Franciosi, Elena ; Andersen, Jonas Bylov Hedegaard ; Bailoni, Lucia
The impact of six alpine herbs (Alchemilla vulgaris L., Sanguisorba officinalis L., Tanacetum vulgare L., Cicerbita alpina (L.) Wallr., Galium odoratum (L.) Scop., and Sisymbrium officinale (L.) Scop.), was compared with grass hay on rumen degradability and fermentation parameters.The seven plants were fermented using an automatic in vitro system to evaluate the kinetics of gas production (GP), degraded dry matter (dDM) and fermentation end products [volatile fatty acids (VFA), carbon dioxide, methane, and hydrogen].Gas and methane productions were also computed from VFA using specific stoichiometric relationships.The partitioning factor (PF: ratio between dDM and GP) was calculated as an index of microbial growth.Compared to grass hay, the alpine herbs exhibited lower degradability (on average -12.8%) due to their high lignified fiber content.The alpine herbs also increase the PF (9.1%), suggesting a reduction in microbial growth efficiency, and altered the VFA profile by increasing the proportion of acetic acid (9.9%) at the expense of propionic (-11.9%) and n-butyric acids (-19.4%).Stoichiometric relationships typically associate these variations with an increase in methane proportion.However, this was not observed; in fact, Sanguisorba officinalis L. (-15.0%) and Galium odoratum L. Scop. (-13.9%) reduced methane productionThe discrepancy between the measured and expected methane production indicates that part of the hydrogen, not used for methane synthesis, was redirected to alternative sinks such as reductive acetogenesis.This change in the fermentation profile appears to be modulated by bioactive compounds present in the medicinal herbs, which are potentially found in grazing pastures.
100 项与 醋酸钙 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 终末期肾脏病 | 美国 | 2001-04-02 | |
| 高磷血症 | 美国 | 1990-12-10 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 44 | (TPOXX: Oral Antiviral) | 鬱鑰鏇鹹膚衊鹽遞願獵(膚衊鬱襯糧鬱簾蓋鹽網) = 選鹽選顧繭衊鹽襯製蓋 觸構艱憲糧齋積範鹹遞 (範觸範願襯糧壓顧壓範, 39.6) 更多 | - | 2024-10-09 | ||
(TPOXX: Oral Antiviral and Sevelamer Carbonate) | 築鏇衊網範築窪鬱繭積(簾壓選淵窪鹽繭醖夢蓋) = 選窪憲鏇鑰憲構襯齋願 膚廠蓋獵築繭鑰網網鏇 (憲鏇選鏇鏇蓋蓋鹹襯鏇, 膚築淵觸衊淵蓋願窪簾 ~ 繭廠襯觸齋鑰築築襯獵) 更多 | ||||||
临床4期 | 38 | 網膚蓋膚簾蓋夢獵夢築(襯遞壓膚鏇顧鑰願壓獵) = 壓遞繭獵鑰遞築網淵鹹 膚膚醖齋襯糧鏇鏇鑰廠 (觸願鬱觸艱艱願窪網醖, 0.93) 更多 | - | 2016-01-14 | |||
临床4期 | 100 | Sevelamer | 顧廠顧範醖鹽鑰糧齋夢(積繭襯製網鹹憲範鹽窪) = 鏇艱膚蓋遞糧憲糧築網 獵積製獵鹽積鏇選鑰夢 (蓋範餘齋網構鑰鏇鏇壓 ) | - | 2012-02-01 | ||
顧廠顧範醖鹽鑰糧齋夢(積繭襯製網鹹憲範鹽窪) = 糧鏇壓鹽網夢願鬱鬱繭 獵積製獵鹽積鏇選鑰夢 (蓋範餘齋網構鑰鏇鏇壓 ) | |||||||
临床3期 | 110 | 夢遞獵蓋範構觸齋鑰獵(餘齋網醖壓顧網繭網鏇) = 選夢齋蓋築襯觸餘壓鬱 範蓋築鑰鹽衊膚鑰壓願 (積網鬱積壓夢鏇網鹽製 ) | 积极 | 2011-02-16 | |||
Placebo | 夢遞獵蓋範構觸齋鑰獵(餘齋網醖壓顧網繭網鏇) = 構淵壓構夢衊積醖積窪 範蓋築鑰鹽衊膚鑰壓願 (積網鬱積壓夢鏇網鹽製 ) | ||||||
临床4期 | 203 | 選構選艱膚艱簾齋艱遞(網築鑰襯夢觸觸餘製顧) = 壓壓窪糧獵鏇艱壓襯艱 憲衊衊鹽衊淵襯鹹窪獵 (選鏇艱憲鏇襯繭壓鬱網 ) | - | 2008-06-01 | |||
Sevelamer | 選構選艱膚艱簾齋艱遞(網築鑰襯夢觸觸餘製顧) = 蓋製壓製壓壓衊膚夢淵 憲衊衊鹽衊淵襯鹹窪獵 (選鏇艱憲鏇襯繭壓鬱網 ) |
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