Mirogabalin Besilate

塞拉维诺片是中科院上海药物所自主研发的1类口服小分子CCR5拮抗剂，用于治疗复发缓解型多发性硬化（RRMS）、ALS（渐冻症）、HIV感染。基本信息 靶点：CCR5（C-C 趋化因子受体 5）拮抗剂，全新骨架小分子口服片剂。作用机制：CCR5是趋化因子受体，一方面是HIV入侵人体细胞的辅助受体；另一方面，在神经免疫疾病（MS、ALS）中，CCR5介导免疫细胞向中枢浸润，驱动炎症、脱髓鞘与神经元损伤。塞拉维诺竞争性阻断CCR5受体，抑制趋化因子介导的免疫细胞迁移，阻断病毒入侵/中枢炎症。 在研适应症 & 临床阶段  HIV感染：最早开发适应症，已完成I期临床，评估安全性、耐受性与药代动力学（CTR20220644） 。 复发缓解型多发性硬化（RRMS）：II期临床进行中（CTR20262072，2026 登记，双盲随机对照）；机制：阻断骨髓来源髓系细胞向中枢迁移，减轻脱髓鞘、神经炎症；动物模型药效优于特立氟胺。 肌萎缩侧索硬化ALS（渐冻症）：2026年2月获NMPA临床批件，目前处于临床阶段；机制：抑制CCR5介导的中枢炎症，延缓运动神经元损伤。关键特点 口服片剂，小分子； 专利布局覆盖中、美、欧、俄、韩、澳等； 临床前安全性较好，种属差异小； 跨领域潜力：从抗感染（HIV）拓展至中枢神经免疫/神经退行性疾病，是CCR5靶点药物的新方向。 研发进展情况  2019.05：HIV适应症获NMPA IND批件，国内首个进入临床的CCR5拮抗剂。 2020–2022：HIV方向I期临床（健康人单次/多次给药 + 初治HIV感染者Ib/IIa）完成；I期结果：安全性、耐受性、PK良好，给药11天可见病毒载量下降、CD4回升，HIV适应症研发暂缓，重心转向神经免疫疾病。 2025.05：复发缓解型多发性硬化（RRMS）IND获批（上海药物所 + 天坛医院施福东团队）。 2026.02：ALS（肌萎缩侧索硬化）IND获批，允许开展临床研究；MS、ALS权益转让，杭州民生药业负责后续临床与商业化开发。 2026.06：RRMS的II期临床试验（THIRL-MS，CTR20262072，全国多中心、随机、双盲、安慰剂对照）在临床试验平台公示，目前处于启动 / 待招募阶段，主要终点评估不同剂量塞拉维诺对MS病灶、复发的初步疗效、安全性、PK。 适应症进展 注册与受理信息 临床试验信息 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【药品分享】普拉替尼胶囊——国内首个获批的高选择性 RET（转染重排）酪氨酸激酶抑制剂 【药品分享】右美托咪定舌下膜——新型 α₂肾上腺素受体激动剂舌下膜剂 【药品分享】卡匹色替片——全球首个获批上市的AKT抑制剂 【药品分享】库莫西利胶囊——全球首个CDK2/4/6抑制剂 【药品分享】赛贝曲司他片——全球首个HAE急性发作口服疗法 【药品分享】KYGEVVI（Doxecitine/Doxribtimine）——全球首款且唯一获批的TK2d针对性治疗药物 【药品分享】Forzinity（Elamipretide）注射剂——全球首个用于治疗Barth综合征的药物 【药品分享】Brinsupri（Brensocatib, 布伦索卡替布）片——全球首个获批上市的二肽基肽酶1（DPP-1）抑制剂 【药品分享】维立西呱片——全球首个心衰适应症的可溶性鸟苷酸环化酶（sGC）刺激剂 【药品分享】盐酸哌罗匹隆片——非典型抗精神病药 【药品分享】盐酸托泊替康胶囊/注射用盐酸托泊替康——经典的拓扑异构酶Ⅰ抑制剂类抗肿瘤药 【药品分享】阿普昔腾坦片——全球首个获批用于难治性高血压的口服双重内皮素受体拮抗剂（ERA） 【药品分享】注射用盐酸依拉环素——全球首个氟环素类抗生素 【药品分享】奥洛格列净胶囊——国内首款抑制SGLT1与SGLT2的1类创新药 【药品分享】盐酸匹米替尼胶囊——国内首个、全球首个获批的腱鞘巨细胞瘤（TGCT）系统性靶向药，高选择性CSF-1R抑制剂 【药品分享】布地奈德肠溶胶囊——全球首个、中国唯一获批用于原发性IgA肾病对因治疗的靶向药物 【药品分享】艾拉莫德片——中国原研、全球首个上市的小分子抗风湿药（csDMARD） 【药品分享】索托克拉片——新一代BCL2抑制剂 【药品分享】利奈昔巴特片——口服、选择性、可逆性回肠胆汁酸转运体（IBAT/ASBT）抑制剂 【药品分享】多替诺雷片——高选择性URAT1抑制剂 【药品分享】瑞普泊肽片——口服GLP‑1/GIP双靶点激动剂 【药品分享】硫酸索西美雷塞片——口服、强效的KRAS G12C共价抑制剂 【药品分享】罗伐昔替尼片——全球首创JAK/ROCK双靶点口服小分子抑制剂 【药品分享】埃诺格鲁肽注射液——全球首个获批上市的cAMP偏向型长效GLP-1受体激动剂 【药品分享】维培那肽注射液——长效GLP-1受体激动剂 【药品分享】普乐司兰钠注射液——全球首个靶向APOC3 mRNA的siRNA降脂药 【药品分享】玛仕度肽注射液——全球首个GCG/GLP-1双激动剂 【药品分享】瑞米布替尼片——全球首个获批用于CSU的口服靶向药 【药品分享】溴莫尼定噻吗洛尔滴眼液——α₂受体激动剂与非选择性 β 受体阻滞剂组成的复方降眼压药 【药品分享】吡洛西利片——国内首个CDK2/4/6多靶点抑制剂 【药品分享】奥氟格列隆片（Orforglipron） ——中国首个、全球首批上市的口服小分子 GLP-1受体激动剂 【药品分享】Copper Histidine注射液（Zycubo）——全球首个、唯一用于治疗儿童门克斯病（Menkes disease）的铜替代注射剂 【药品分享】依来格列隆片（Elecoglipron）——口服小分子非肽类GLP-1受体激动剂 【药品分享】阿利奈普仑（Aleniglipron）——口服小分子、非肽类、偏向性GLP-1受体激动剂 【药品分享】甲磺酸阿美替尼片——中国首个原研三代EGFR酪氨酸激酶抑制剂（TKI） 【药品分享】甲磺酸达麦利替尼片——口服高选择性c-MET酪氨酸激酶抑制剂 【药品分享】盐酸Acoramidis片——转甲状腺素蛋白（TTR）稳定剂 【药品分享】阿莫西林伏诺拉生胃漂浮片——3D打印胃漂浮片 【药品分享】盐酸伊可白滞素片——全球首创口服IL‑23受体拮抗剂 【药品分享】马来酸吡咯替尼片——中国首个自研的HER1/HER2/HER4不可逆酪氨酸激酶抑制剂（TKI） 【药品分享】本维莫德乳膏——全球首创芳香烃受体（AhR）调节剂（TAMA）类皮肤病外用药 【药品分享】盐酸莫托咪酯注射液——化药1类静脉麻醉新药 【药品分享】注射用罗哌卡因微晶——长效缓释局部麻醉药 【药品分享】盐酸伊立替康脂质体注射液——一款针对吉西他滨治疗失败的转移性胰腺癌的二线标准脂质体化疗药 【药品分享】甲磺酸氟马替尼片——Bcr-Abl酪氨酸激酶选择性抑制剂 【药品分享】注射用阿加糖酶β——国内获批的首个用于治疗法布雷病的药物 【药品分享】甲苯磺酸尼拉帕利胶囊——高选择性PARP1/2抑制剂 【药品分享】帕米帕利胶囊——强效、选择性PARP1/2抑制剂 【药品分享】苯环喹溴铵鼻喷雾剂——选择性M胆碱能受体拮抗剂 【药品分享】注射用拉罗尼酶浓溶液——MPS Ⅰ型的特异性酶替代治疗药物 【药品分享】海博麦布片——国产自主原研的胆固醇吸收抑制剂 【药品分享】盐酸可洛派韦胶囊——直接抗病毒药物（DAA）→ NS5A抑制剂 【药品分享】克拉考特酮乳膏——外用、非甾体、选择性雄激素受体（AR）抑制剂 【药品分享】非卢替尼片——全球首个用于多发性硬化的口服BTK抑制剂 【药品分享】Brenipatide注射液——GLP-1R/GIPR双受体激动剂（继替尔泊肽之后的第二款） 【药品分享】罗赛促红素α注射液——国产首个长效重组促红细胞生成素（EPO）创新药 【药品分享】贝组替凡片——全球首个口服小分子HIF-2α抑制剂 【药品分享】那米司特片——口服选择性PDE4B抑制剂 【药品分享】富马酸立康可泮胶囊——一款针对罕见病PNH的口服补体B因子抑制剂 【药品分享】醋酸索乐匹尼布片——高选择性脾酪氨酸激酶（Syk）抑制剂 【药品分享】甲磺酸艾多替尼片——全球首款专为肺癌脑转移设计的第三代EGFR-TKI 【药品分享】安瑞克芬注射液——全球首个获批镇痛适应症的高选择性外周κ-阿片受体（KOR）激动剂 【药品分享】Difelikefalin注射液——全球首个获批的外周选择性κ-阿片受体（KOR）激动剂 【药品分享】Obefazimod——口服、靶向 CBC、特异性增强miR-124的首创小分子 【药品分享】拉尼兰诺片——口服泛PPAR激动剂 【药品分享】舒洛地特注射液——抗血栓药、血管保护剂 【药品分享】贝普若韦生注射液——反义寡核苷酸（ASO）类乙肝新药 【药品分享】氨酚右敏口服溶液（奥肯能®）——中国内地唯一获批的氨酚右敏口服溶液 【药品分享】佩玛贝特片——新型过氧化物酶体增殖物激活受体α/δ双重激动剂 (PPARα/δ) 【药品分享】盐酸依匹斯汀乳膏——外用第二代非镇静抗组胺抗过敏药膏 【药品分享】注射用双羟萘酸帕瑞肽微球——一款用于治疗肢端肥大症的第二代长效生长抑素类似物（SRL）微球制剂 【药品分享】埃拉菲布拉诺片——治疗原发性胆汁性胆管炎（PBC）的口服靶向新药 【药品分享】泽卢克布仑钠注射液——新一代皮下注射型C5补体抑制剂 【药品分享】依达拉奉右莰醇注射用浓溶液——一款复方神经保护类注射剂 【药品分享】醋酸戈那瑞林注射液——促性腺激素释放激素（GnRH）类药物 【药品分享】甲磺酸贝舒地尔片——全球首个选择性ROCK2激酶抑制剂 【药品分享】伊托法替布软膏——外用JAK抑制剂（JAK1/JAK3） 【药品分享】注射用华卟啉钠——新型肿瘤光动力治疗（PDT）专用光敏剂 【药品分享】优替德隆胶囊——口服埃博霉素类微管抑制剂 【药品分享】艾普美妥司他片——EZH1/2双靶创新药 【药品分享】精氨酸艾曲莫德片——新型选择性鞘氨醇1-磷酸受体（S1P₁）调节剂 【药品分享】磷酸芦可替尼乳膏——全球/国内首款、唯一获批用于非节段型白癜风复色的外用JAK1/JAK2选择性抑制剂 【药品分享】盐酸右哌甲酯缓释胶囊——治疗6岁及以上注意缺陷多动障碍（ADHD）的一线药物 【药品分享】抗菌肽PL-3301口腔凝胶——中国首创的抗菌肽类抗口腔真菌感染药物 【药品分享】Zasocitinib (TAK-279) 胶囊——新一代高选择性口服 TYK2 抑制剂 【药品分享】注射用Abelacimab——一款全人源IgG1单克隆抗体，靶向凝血因子XI（FXI） 【药品分享】Duvakitug注射液——首创性人源化IgG1-λ2单克隆抗体，靶向TL1A（TNFSF15） 【药品分享】醋酸氟轻松/氢醌/维A酸乳膏——治疗中重度黄褐斑疗效明确的外用复方 【药品分享】富马酸伏诺拉生氯化钠注射液——钾离子竞争性酸阻滞剂（P‑CAB）||东阳光药业研发的2.2,2.4类改良新型新药 【药品分享】盐酸阿曲生坦片——诺华研发的高选择性内皮素 A（ETA）受体拮抗剂||中国首个获批用于IgA 肾病的非免疫性口服靶向药 【药品分享】RGT-274-CR胶囊——上海齐鲁锐格医药研发的口服小分子GLP-1受体激动剂 【药品分享】酒石酸西尼必利片——高选择性5-HT₄受体激动剂类胃肠动力药 【药品分享】石杉碱甲控释片——采用双相控释/渗透泵技术的2.2类改良型新药 【药品分享】塞伐艾替尼片——口服、可逆、选择性酪氨酸激酶抑制剂（TKI） 【药品分享】Admilparant片——口服小分子LPA₁受体拮抗剂 【药品分享】瑞拉可兰胶囊——全球首个选择性糖皮质激素受体（GR）拮抗剂 【药品分享】盐酸依特卡肽注射液——全球首个、国内唯一获批的静脉注射型拟钙剂 【药品分享】Avacincaptad pegol玻璃体内注射液——全球首批用于AMD继发地图样萎缩（GA）的靶向药物 【药品分享】盐酸达利雷生片——新一代非管制、非苯二氮䓬类抗失眠药物 【药品分享】甲磺酸瑞索利塞片——高选择性PI3Kα小分子靶向抑制剂 || 全球首个获批用于特定卵巢癌的靶向新药 【药品分享】富马酸西他沙星注射液——新型喹诺酮类抗菌药物 【药品分享】Icotrokinra——全球首个获批的口服 IL-23 受体（IL-23R）选择性拮抗多肽 【药品分享】氘可来昔替尼片（Deucravacitinib）——全球首个口服、选择性 TYK2 变构抑制剂 【药品分享】柯美奇拜单抗注射液——鼻用糖皮质激素治疗后症状控制不佳的成人中重度季节性过敏性鼻炎患者的福音 【药品分享】吉诺昔替尼——口服小分子JAK1/TYK2双重抑制剂 【药品分享】洛替拉纳（Lotilaner）——GABA 门控氯离子通道非竞争性拮抗剂 || 兼具兽医驱虫与人用眼科两大用途 【药品分享】CagriSema——由卡格列肽（cagrilintide）2.4 mg与司美格鲁肽（semaglutide）2.4 mg组成的强效减重复方药 【药品分享】苹果酸卡博替尼——口服、多靶点酪氨酸激酶抑制剂（TKI） 【药品分享】迪高替尼（Delgocitinib）——一款外用泛JAK抑制剂 【药品分享】拉氟莫司(Laflunimus)——口服免疫抑制剂 || 兼具免疫抑制与抗炎双重活性 【药品分享】伏昔尼布片——全球首个IDH1/IDH2双重突变抑制剂靶向药 【药品分享】盐酸奥昔布宁片——M受体抗胆碱药 【药品分享】贝泽昔替尼片——国内首款获批的高选择性JAK2单靶点抑制剂 【药品分享】苯甲酸安达艾替尼胶囊——新型小分子酪氨酸激酶不可逆抑制剂（EGFR-TKI） 【药品分享】伏欣奇拜单抗注射液——全人源抗IL‑1β单克隆抗体 || 用于急性痛风性关节炎的1类创新生物药 【药品分享】利多卡因丁卡因乳膏 【药品分享】伐米奇拜单抗注射液——玻璃体内注射用抗IL-6人源化单抗 【药品分享】依赛弗酶α注射液（Efzimfotase alfa 注射液）——第二代重组组织非特异性碱性磷酸酶（TNSALP）酶替代疗法 【药品分享】格达托利西布（Gedatolisib）——first‑in-class 泛 PI3K/mTORC1/2 双重抑制剂 【药品分享】伯瑞替尼肠溶胶囊——中国原研、高选择性c-MET小分子抑制剂 || 首个获批MET扩增NSCLC单药治疗的靶向药 【药品分享】力胜克拉片——中国首个申报上市的原研Bcl-2抑制剂、全球第二款Bcl-2抑制剂 【药品分享】BGM0504注射液——GLP-1/GIP 双受体激动剂 【药品分享】塞利尼索片——全球首个口服选择性核输出蛋白XPO1抑制剂 【药品分享】Seltorexant薄膜包衣片——选择性食欲素2受体（OX2R）高选择性拮抗剂 【药品分享】盐酸埃克替尼片——国内首个自主研发的一代EGFR-TKI 【药品分享】盐酸伊普可泮胶囊——全球首个口服补体B因子抑制剂 【药品分享】恩考芬尼胶囊——靶向BRAF V600突变的口服激酶抑制剂 【药品分享】Enpatoran——口服、选择性TLR7/8小分子抑制剂 【药品分享】硝酸异康唑阴道片——抗真菌外用药物 【药品分享】Zorevunersen注射液——全球独家ASO上调蛋白表达技术 【药品分享】妥拉美替尼胶囊——全球首个针对NRAS突变黑色素瘤的MEK抑制剂 【药品分享】盐酸替那帕诺片——全球首创NHE3抑制剂类新型降磷药物 【药品分享】注射用莱古比星——新型蒽环类抗肿瘤药 【药品分享】优替德隆胶囊——口服埃博霉素类微管抑制剂 【药品分享】伊那利塞片——中国首个PIK3CA突变乳腺癌精准靶向药 【药品分享】呋喹替尼胶囊——中国首个自主研发VEGFR-TKI || VEGFR靶点靶向抗癌药 【药品分享】琥珀酸瑞波西利片——CDK4/6抑制剂 【药品分享】盐酸替那帕诺片——全球首个且唯一获批的肠道磷吸收抑制剂 【药品分享】芬布替尼片——口服、可逆、可透过血脑屏障的BTK抑制剂 【药品分享】炔丙基半胱氨酸胶囊——全球首个进入临床的硫化氢（H₂S）供体I类创新药 【药品分享】Balcinrenone达格列净胶囊——选择性盐皮质激素受体拮抗剂（MRA）+SGLT-2抑制剂 【药品分享】诺拉西班（Nolasiban）分散片——选择性口服催产素受体拮抗剂 || 早产二线/辅助治疗药物 【药品分享】塞多明基注射液——国内首款裸质粒基因治疗药物 【药品分享】鲁兹诺雷钠片——国产首个高选择性URAT1抑制剂 【药品分享】玛伐凯泰胶囊——全球首创、中国唯一获批的心肌肌球蛋白抑制剂 【药品分享】依托芬那酯凝胶——外用非甾体抗炎镇痛药 【药品分享】聚卡波非钙片——国际指南首选容积性缓泻剂 【药品分享】Mezigdomide胶囊——新一代IMiDs/cereblon E3泛素连接酶调节 【药品分享】洛布替尼片——全球首款共价+非共价双机制第四代 BTK 靶向药 【药品分享】奥莱泊肽注射液——PEG修饰长效GLP‑1单靶点激动剂 【药品分享】安瑞曲替尼胶囊 ——国内第二款国产二代NTRK广谱抗癌药 【药品分享】麦格司他胶囊——抑制葡萄糖神经酰胺合成酶的罕见病口服靶向药 【药品分享】乌帕替尼片（Upadacitinib）——选择性JAK1抑制剂 【药品分享】Dordaviprone胶囊——全球首款、目前唯一获批用于 H3 K27M 突变型弥漫性中线胶质瘤（DMG）的靶向药 【药品分享】屈昔多巴胶囊——去甲肾上腺素前体药物  || 帕金森、多系统萎缩、神经源性体位低血压一线对症用药 【药品分享】康特替尼颗粒——第二代ALK多靶点激酶抑制剂 【药品分享】盐酸兰诺可泮片——国产首个获批上市的补体因子B（CFB）抑制剂 【药品分享】Elinzanetant软胶囊——全球首款NK1/NK3双重神经激肽受体拮抗剂 【药品分享】Fosmanogepix注射液——全球首创（First-in-class）Gwt1抑制剂类抗真菌前药 【药品分享】Zorevunersen注射液——反义寡核苷酸药物 【药品分享】宗艾替尼片——高选择性不可逆HER2（ERBB2）酪氨酸激酶抑制剂（TKI） 【药品分享】甲苯磺酸他拉唑帕利胶囊——高选择性PARP抑制剂 【药品分享】Bexicaserin口服溶液——选择性5-HT2C受体激动剂口服液体制剂 【药品分享】醋酸伏诺拉生注射用浓溶液——钾离子竞争性酸阻滞剂（P-CAB） 【药品分享】甲苯磺酸依仑司群片——新一代口服选择性雌激素受体降解剂（SERD） 【药品分享】硫酸瑞美吉泮口崩片——CGRP 受体拮抗剂（降钙素基因相关肽）|| 偏头痛靶向特效药 【药品分享】阿托吉泮片——全球首款口服长效CGRP靶点预防偏头痛药物 【药品分享】乌布吉泮片——CGRP受体拮抗剂 || 第二代口服偏头痛急性期药物 【药品分享】扎维吉泮鼻喷雾剂——高选择性CGRP受体拮抗剂  || 全球唯一获批鼻喷CGRP吉泮类急性期药物 【药品分享】培来加南喷雾剂——全球首款上市加南类多肽抗菌药（FIC） 【药品分享】艾沙利酮片——高选择性非甾体醛固酮受体拮抗剂（MRA）  || 全球首个上市的非甾体选择性MR拮抗剂 【药品分享】布美他尼鼻喷雾剂——全球首款、唯一鼻内给药袢利尿剂 【药品分享】注射用盐酸依拉环素——新型全合成氟环素类（四环素衍生物）静脉抗生素 【药品分享】舒瑞基奥仑赛注射液——全球首款实体瘤自体CLDN18.2靶向CAR-T细胞新药 【药品分享】盐酸环喷托酯滴眼液——儿童验光首选短效睫状肌麻痹剂之一 【药品分享】盐酸赛庚啶口服溶液——抗过敏抗组胺药 【药品分享】Rinzimetostat (ORIC-944)——口服选择性 EED别构型PRC2表观遗传抑制剂 【药品分享】Empasiprubart注射用浓溶液——全球首创靶向补体C2人源化IgG1清扫型单克隆抗体 【药品分享】阿更葡糖钠注射液——全球第二款、中国首款自主研发的环糊精类靶向肌松逆转剂 【药品分享】盐酸罗哌卡因缓释溶液——国产自主长效局麻缓释制剂 || 填补国内切口原位长效镇痛空白 【药品分享】Telisotuzumab Adizutecan 注射用粉末——抗c-Met抗体偶联药物（ADC） 【药品分享】L606 (曲前列尼尔脂质体吸入混悬液)——靶向肺动脉高压 【药品分享】佩米替尼片——选择性FGFR1/2/3酪氨酸激酶抑制剂 【药品分享】唑尼沙胺胶囊——磺酰胺类结构 || 广谱抗癫痫药，偏头痛预防 【药品分享】琥珀酸安维吖啶片——双靶点胆碱酯酶抑制剂 【药品分享】布莱昔替尼片（Bleximenib）——口服高选择性Menin-KMT2A相互作用抑制剂 【药品分享】利厄替尼片——第三代EGFR-TKI靶向药 【药品分享】注射用苯磺酸瑞马唑仑——苯二氮䓬类短效静脉镇静/麻醉药 【药品分享】瑞维鲁胺片——国产全新二代雄激素受体抑制剂 【药品分享】塞普替尼胶囊——全球首款高选择性RET靶向药  || 国内唯一拥有12岁以上儿童甲状腺肿瘤完整临床证据的RET抑制剂 【药品分享】注射用和厚朴酚脂质体冻干粉——全球首创小分子脂质体靶向制剂 【药品分享】注射用顺铂聚合物胶束——前沿纳米化疗创新赛道  || 改良型新药-纳米靶向注射制剂 【药品分享】奥普雷顿片——国内首个获批的口服OX2R选择性激动剂 【药品分享】琥珀酸思普可泮片——口服选择性补体B因子（CFB/FB）小分子抑制剂  || 全球首个每日一次口服FB抑制剂 【药品分享】苹果酸法米替尼胶囊——多靶点TKI创新药  || 国内唯一获批用于宫颈癌的口服抗血管TKI 【药品分享】盐酸伊普可泮胶囊 【药品分享】枸橼酸伊沙佐米胶囊——第二代、全球首个口服可逆性蛋白酶体抑制剂 【药品分享】注射用西罗莫司（白蛋白结合型）——mTOR 激酶抑制剂  || 白蛋白纳米粒递送系统 【药品分享】Bleximenib片——Menin抑制剂（KMT2A/Menin 相互作用抑制剂） 【药品分享】Eloralintide注射液——选择性长效胰淀素（Amylin）受体激动剂（AMY1R激动剂） 【药品分享】阿柏西普眼内注射溶液——重组人源VEGF融合蛋白的治疗用生物制品 【药品分享】艾托莫德片——高选择性S1PR1（鞘氨醇‑1‑磷酸受体1）小分子激动剂 【药品分享】GBI268注射液——复方局部镇痛注射剂 【药品分享】Edecesertib片——IRAK‑4小分子激酶抑制剂 【药品分享】阿布昔替尼片——高选择性JAK‑1小分子抑制剂 【药品分享】盐酸阿思尼布片——全球首个且目前唯一基于ABL肉豆蔻酰口袋（STAMP）创新机制的靶向药物 【药品分享】Venglustat——葡萄糖神经酰胺合成酶（GCS/UGCG）抑制剂 【药品分享】塞瑞替尼胶囊——第二代ALK酪氨酸激酶抑制剂（ALK-TKI） 【药品分享】泊那替尼片——第三代BCR-ABL酪氨酸激酶抑制剂（TKI）|| 唯一能够有效抑制BCR‑ABL T315I耐药突变的TKI 【药品分享】盐酸阿那格雷胶囊——PDE3抑制剂 【药品分享】奥雷巴替尼片——国内首个获批可有效抑制T315I突变的三代BCR-ABL抑制剂 【药品分享】比克恩丙诺片——HIV‑1感染单片复方抗病毒药 【药品分享】甲磺酸奥希替尼片——第三代EGFR靶向药 【药品分享】醋酸戈舍瑞林缓释植入剂——促性腺激素释放激素激动剂缓释皮下植入制剂 【药品分享】拉考沙胺缓释胶囊——钠通道调节剂 【药品分享】纳曲酮利培酮植入剂——新的缓释植入剂型 【药品分享】普那布林注射用浓溶液——GEF‑H1（ARHGEF2）激动剂 【药品分享】Petrelintide注射液——长效胰淀素（Amylin）受体激动剂 【药品分享】酒石酸凡瑞格拉替尼片——1类高选择性FGFR口服小分子创新药 【药品分享】醋酸兰瑞肽缓释注射液（预充式）——长效生长抑素类似物（SSA） 【药品分享】吡非尼酮胶囊——多细胞因子通路调节剂 【药品分享】罗替高汀贴片——非麦角类多巴胺受体激动透皮贴剂  || 全球首个经皮吸收的帕金森治疗药物 【药品分享】芦沃美替尼片——高选择性MEK1/2（丝裂原活化蛋白激酶激酶 1/2）抑制剂 【药品分享】硫酸阿托品滴眼液——竞争性 M‑胆碱（毒蕈碱）受体拮抗剂 【药品分享】盐酸恩沙替尼胶囊——国产第二代间变性淋巴瘤激酶(ALK)-酪氨酸激酶抑制剂(TKI)靶向药 【药品分享】富马酸奥赛利定注射液——新型静脉镇痛药物 || G蛋白偏向性μ‑阿片受体激动剂 【药品分享】司美格鲁肽微针贴片——用于2型糖尿病与肥胖体重管理的新剂型药品 【药品分享】甲苯磺酸利特昔替尼胶囊——国内首个获批可用于12–17岁青少年重度斑秃的口服系统治疗药物 【药品分享】艾曲帕米鼻喷雾剂——经鼻给药的速效钙通道阻滞剂 【药品分享】盐酸替扎尼定胶囊——中枢性α2肾上腺素受体激动剂 【药品分享】格贝前列素滴眼液——单分子双功能NO供体型前列腺素前药 【药品分享】盐酸伊司特韦片——全球首个依托DEL结合AI技术成功获批的原创小分子药物 【药品分享】布格替尼片——口服小分子ALK酪氨酸激酶抑制剂 【药品分享】司来帕格片——口服选择性前列腺素受体（IP受体）激动剂 【药品分享】甲磺酸伏美替尼片——国产第三代EGFR靶向药（EGFR-TKI） 【药品分享】帕替罗姆山梨醇钙干混悬剂——不吸收入血的口服阳离子交换聚合物类新型降钾药物 免责声明：本文仅作医药信息传播分享，并不构成投资或决策建议。

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放 截至09月24日15点59分，近期共有 552 本期刊发布了 1034 篇文章，其中糖尿病相关的文章共 305 篇，覆盖 30 个领域的内容。中国专家参与发表的文章有 78 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。 今日头条 Headlines 01 European Heart Journal IF: 35.600 司美格鲁肽与心血管风险降低：SELECT研究的中介分析 Colhoun, Helen M, Lincoff, A Michael, Ryan, Donna, Lingvay, Ildiko, Kahn, Steven E, Hovingh, G Kees, etc. SELECT研究既往已证实，在超重或肥胖且无糖尿病的动脉粥样硬化性心血管疾病（ASCVD）患者中，司美格鲁肽每周皮下注射2.4 mg可显著降低主要不良心血管事件风险达20%。然而，这一心血管获益的确切机制尚不明确。 本研究对SELECT试验进行了预先设定的中介分析，采用Vansteelandt反事实重复回归方法，评估了体重、腰围、高敏C反应蛋白、糖化血红蛋白、血脂、血压、估算肾小球滤过率和尿白蛋白肌酐比等12项潜在中介因素在司美格鲁肽降低主要不良心血管事件风险中的作用。 结果显示，司美格鲁肽显著改善了所有潜在中介因素。在单独分析中，腰围的中介比例点估计值最大，为64.0%（95%置信区间[CI] 27.5~179.6），其次为高敏C反应蛋白42.1%（17.9~110.5）、糖化血红蛋白29.0%（-20.7~120.5）和体重19.5%（-33.0~110.7），但所有置信区间均较宽。补充分析提示体重和腰围的估计可能不可靠，可能与治疗组间体重和腰围变化与主要不良心血管事件的关系不同有关。多因素联合分析中，所有潜在中介因素的总中介比例为31.4%（95%CI -30.1~143.6）；当排除体重和腰围后，中介比例为46.0%（95%CI -6.0~161.0）。 结论指出，中介分析无法完全确定地将司美格鲁肽对主要不良心血管事件的影响归因于SELECT研究中已知的风险因素。进一步研究其他潜在生物标志物和司美格鲁肽心血管保护作用的中介因素具有重要意义。 本文由 韩玉莲 编辑 扫描二维码查看源文 European Heart Journal | Ahead of Print. 10.1093/eurheartj/ehag524 02 Nutritional neuroscience IF: 03.600 维生素D水平不足加重糖尿病周围神经病变，补充维生素D可缓解神经病理性疼痛 Bassel Alrabadi, Hasan I Matar, Natalie Bandak, Yousef Alghzawi, Alwaleed Emad Alshakhshir, Fadi Alrabadi, etc. 维生素D缺乏被认为是糖尿病周围神经病变的潜在促发因素，但其临床相关性证据仍不一致。一项系统综述、荟萃分析与荟萃回归研究评估了维生素D缺乏与糖尿病周围神经病变之间的关联，并评价了补充维生素D对神经病变结局的影响。该研究检索了PubMed、Scopus与Web of Science从建库至2025年6月的文献，纳入比较糖尿病伴或不伴糖尿病周围神经病变患者维生素D水平的观察性研究，以及评估补充维生素D的干预性研究。采用随机效应荟萃分析，计算标准化均数差与95%置信区间，并通过荟萃回归评估年龄与体重指数的影响。 研究共纳入33项研究，涉及17,369名参与者。在12项观察性研究（n=2,937）中，糖尿病周围神经病变患者的血清维生素D水平显著低于无神经病变者（SMD=-0.90，95%置信区间[CI] -1.51~-0.30；P=0.003）。在7项干预性研究（n=437）中，补充维生素D显著提高了血清维生素D浓度（SMD=2.54，95%CI 1.05~4.03；P=0.008），并减轻了神经病理性疼痛严重程度（SMD=-1.30，95%CI -1.73~-0.86；P<0.0001）。补充维生素D对HbA1c水平未观察到显著影响（SMD=-0.35，95%CI -0.87~0.17；P=0.18）。荟萃回归分析显示，年龄或体重指数均无显著调节作用。 讨论指出，维生素D缺乏与糖尿病周围神经病变显著相关，补充维生素D可改善神经病理性疼痛，同时提高血清维生素D浓度。这些获益似乎独立于血糖控制。尽管研究间存在显著异质性，但研究结果支持将补充维生素D作为糖尿病神经病变的一种潜在安全且低成本的辅助治疗。仍需进一步开展大规模随机对照试验，以确定最佳补充策略并确认长期临床获益。 本文由 韩玉莲 编辑 扫描二维码查看源文 Nutritional neuroscience | Ahead of Print. 10.1080/1028415X.2026.2730594 03 Frontiers in nutrition IF: 05.100 患者特征与减重药物早期使用体验：CAMP研究 Colleen Tewksbury, Emma Adelia Soliva, Krista Scheffey, Pui Lui Kwong, Karen Glanz, etc. CAMP研究是一项在大型学术医疗系统内开展的两阶段横断面研究，旨在描述接受司美格鲁肽或替尔泊肽处方的患者特征及其早期用药体验。第一阶段通过电子健康记录识别了21,610例在2023年7月至2024年6月期间因体重管理接受处方的成人患者。这些患者以女性、白人和私人保险为主，平均年龄49岁，平均体重指数36 kg/m²。大多数处方由初级保健提供者开具。 第二阶段对第一阶段患者进行在线调查，共2,628人完成。受访者平均年龄48.5岁，平均体重指数35.0 kg/m²，以女性（74.1%）、非西班牙裔（96.3%）和白人（74.4%）为主。司美格鲁肽是最常见的初始处方（58.5%）。90.1%的受访者成功获取初始处方，80.5%仍在接受治疗。 在512名报告停药的受访者中，最常见原因包括保险覆盖终止（37.7%）、副作用（27.1%）和高药物费用（20.3%）。其他原因包括决定停药（19.5%）、药物短缺（8.4%）、缺乏有效性（6.3%）和未取药（4.7%）。 尽管88.0%的受访者表示接受了用药指导，但仅27.0%被转诊至其他健康服务，最常见的是营养咨询（90.0%）。在获得转诊的患者中，70.5%完成了推荐服务。 研究结论指出，经济障碍是治疗中断的主要原因，而营养和行为服务的转诊率较低。这些发现为减重药物的实际应用提供了重要见解，并确定了改善可及性、持续使用和多学科肥胖治疗的杠杆点。 本文由 韩玉莲 编辑 扫描二维码查看源文 Frontiers in nutrition | Volume 13, Issue 10.3389/fnut.2026.1931188 中国发表（78） China Pediatric obesity IF: 02.700Volume 21, Issue 9No.01Associations Between Sources of Secondhand Smoke Exposure and Overweight and Obesity Among Chinese School-Aged Youth中国学龄青少年二手烟暴露来源与超重和肥胖的关联DOI: 10.1111/ijpo.70152 Peptides IF: 02.900Ahead of Print.No.02Advances in Weight-Loss-Independent Cardiovascular Protective Mechanisms of GLP-1 Receptor AgonistsGLP-1受体激动剂不依赖减重的心血管保护机制研究进展DOI: 10.1016/j.peptides.2026.171519 BMJ open IF: 02.300Volume 16, Issue 9No.03Cohort profile: the Shenzhen Birth Cohort (SZBC) study队列简介：深圳出生队列（SZBC）研究DOI: 10.1136/bmjopen-2026-121066 Journal of proteomics IF: 02.800Ahead of Print.No.04Integrated proteomic characterization of maternal blood, umbilical cord blood and placental tissue in gestational diabetes mellitus妊娠期糖尿病母血、脐带血和胎盘组织的整合蛋白质组学特征DOI: 10.1016/j.jprot.2026.105736 Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.05The estimated time fraction within range may mask prognostically distinct glycaemic profiles in critical illness: a three-database landmark study估计范围内时间分数可能掩盖危重症中预后不同的血糖谱：一项三数据库标志性研究DOI: 10.1016/j.diabres.2026.113579 Medical image analysis IF: 11.800Ahead of Print.No.06Advancing automated phase recognition in cataract surgery through the SICS-155 challenge通过SICS-155挑战推进白内障手术中的自动阶段识别DOI: 10.1016/j.media.2026.104313 Talanta IF: 06.100Ahead of Print.No.07Diagnosis of diabetic nephropathy imaging and evaluation of therapeutic efficacy using fluorescence-magnetic resonance dual-modal molecular probes利用荧光-磁共振双模态分子探针诊断糖尿病肾病成像并评估有效性DOI: 10.1016/j.talanta.2026.130649 J Colloid Interface Sci IF: 09.700Ahead of Print.No.08Engineering a biocompatible nanozyme hydrogel: Synergistic nanozyme catalysis and photothermal therapy for diabetic wound repair工程化生物相容性纳米酶水凝胶：协同纳米酶催化与光热疗法促进糖尿病创面修复DOI: 10.1016/j.jcis.2026.141543 Mol Cell Endocrinol IF: 03.600Ahead of Print.No.09Impaired FXR-Syntaxin 1A Pathway Contributes to Diabetic β-Cell Secretory Dysfunction受损的FXR-Syntaxin 1A通路导致糖尿病β细胞分泌功能障碍DOI: 10.1016/j.mce.2026.112927 Biochim Biophys Acta Proteins Proteom IF: 02.300Ahead of Print.No.10Integrated plasma proteomic and metabolomic profiling demonstrated specific proteins and bile acids remodeling after liver transplantation of children with biliary atresia整合血浆蛋白质组学和代谢组学分析揭示胆道闭锁儿童肝移植后特定蛋白质和胆汁酸的重塑DOI: 10.1016/j.bbapap.2026.141181 Eur J Obstet Gynecol Reprod Biol IF: 01.900Ahead of Print.No.11Construction and verification of a prediction model for gestational diabetes mellitus complicated with gestational hypertension based on a specialized disease research database基于专病研究数据库构建和验证妊娠期糖尿病合并妊娠期高血压疾病的预测模型DOI: 10.1016/j.ejogrb.2026.115449 Biochemical pharmacology IF: 05.600Ahead of Print.No.12GLP-1 receptor agonists and podocyte senescence in diabetic kidney disease: structural pharmacology, mechanistic evidence, and multi-receptor agonism胰高血糖素样肽-1受体激动剂与糖尿病肾脏病中的足细胞衰老：结构药理学、机制证据与多受体激动作用DOI: 10.1016/j.bcp.2026.118495 Journal of animal science IF: 02.900Volume 104, Issue No.13Gamma-aminobutyric acid modulates buck semen quality and sperm preservation duration in vivo and in vitroγ-氨基丁酸在体内和体外调节公羊精液质量和精子保存时间DOI: 10.1093/jas/skag294 Peptides IF: 02.900Ahead of Print.No.14Erythropoietin-derived peptide (HBSP) inhibits caspase-3/GSDME through HMGB1 to regulate pyroptosis and reduce diabetic retinopathy促红细胞生成素衍生肽（HBSP）通过HMGB1抑制caspase-3/GSDME调控细胞焦亡并减轻糖尿病视网膜病变DOI: 10.1016/j.peptides.2026.171520 Phytomedicine IF: 08.300Ahead of Print.No.15Quercetin alleviates painful diabetic neuropathy in association with gut microbial remodeling and spinal betaine-related metabolic changes槲皮素缓解糖尿病痛性神经病变与肠道微生物重塑及脊髓甜菜碱相关代谢变化相关DOI: 10.1016/j.phymed.2026.158812 BMJ Open Diabetes Res Care IF: 04.100Volume 14, Issue 5No.16Associations of Life's Essential 8 cardiovascular health score with prevalent microvascular complications stratified by sex and menopausal status in Chinese adults with type 2 diabetes: a cross-sectional study中国2型糖尿病成人中Life's Essential 8心血管健康评分与微血管并发症患病率的关联：按性别和绝经状态分层的横断面研究DOI: 10.1136/bmjdrc-2026-006185 JMIR medical informatics IF: 03.800Volume 14, Issue No.17Longitudinal Digital Phenotyping of Traditional Chinese Medicine Constitution From Routine Health Examination Records: Retrospective Clinical Informatics Study基于常规健康体检记录的中医体质纵向数字表型分析：回顾性临床信息学研究DOI: 10.2196/100063 JAMA Network Open IF: 09.700Volume 9, Issue 9No.18Continuous Glucose Monitoring Alert Settings and Glycemic Control in People With Diabetes糖尿病患者持续葡萄糖监测警报设置与血糖控制DOI: 10.1001/jamanetworkopen.2026.35687 JAMA Network Open IF: 09.700Volume 9, Issue 9No.19Oral Corticosteroid Bursts and Risk of Serious Adverse Events in Adults With Type 2 Diabetes口服皮质类固醇冲击治疗与2型糖尿病成人严重不良事件风险DOI: 10.1001/jamanetworkopen.2026.35604 European journal of epidemiology IF: 05.900Ahead of Print.No.20Systolic blood pressure variability as a risk factor for abdominal aortic aneurysm: a prospective cohort study with genomic and proteomic profiling收缩压变异性作为腹主动脉瘤的危险因素：一项结合基因组与蛋白质组学分析的前瞻性队列研究DOI: 10.1007/s10654-026-01459-2 Acta diabetologica IF: 02.900Ahead of Print.No.21Association between peripheral blood biomarkers and diabetic macular edema外周血生物标志物与糖尿病性黄斑水肿之间的关联DOI: 10.1007/s00592-026-02799-x Acta Biochim Biophys Sin (Shanghai) IF: 03.400Ahead of Print.No.22Midazolam suppresses glioma progression by attenuating neuronal activity and downregulating IGF1 signaling咪达唑仑通过减弱神经元活动并下调IGF1信号通路抑制胶质瘤进展DOI: 10.3724/abbs.2026109 Natural product research IF: 01.600Ahead of Print.No.23Nocarpiperazine A reduces lipid deposition and oxidative stress in Caenorhabditis elegansNocarpiperazine A 减少秀丽隐杆线虫的脂质沉积和氧化应激DOI: 10.1080/14786419.2026.2736649 Cell reports IF: 06.900Ahead of Print.No.24Alternate day fasting attenuates metabolic dysfunction-associated arterial thrombotic risk via increasing indole-3-propionic acid隔日禁食通过增加吲哚-3-丙酸减轻代谢功能障碍相关动脉血栓风险DOI: 10.1016/j.celrep.2026.118032 Current obesity reports IF: 11.000Volume 15, Issue 1No.25Beyond Pleasure: Unraveling the Multifaceted Role of Dopamine in Obesity and Metabolic Regulation超越愉悦：揭示多巴胺在肥胖与代谢调控中的多重作用DOI: 10.1007/s13679-026-00763-y Acta pharmaceutica IF: 01.400Ahead of Print.No.26A meta-analysis of the effects of Zingiber officinale on metabolic indices among patients with type 2 diabetes姜对2型糖尿病患者代谢指标影响的荟萃分析DOI: 10.2478/acph-2026-0020 PloS one IF: 02.600Volume 21, Issue 9No.27Use of faricimab for refractory diabetic macular edema in real-world clinical practice: When anatomical success meets functional limits真实世界临床实践中应用法瑞西单抗治疗难治性糖尿病性黄斑水肿：当解剖学成功遇上功能学局限DOI: 10.1371/journal.pone.0358993 JCPT IF: 02.800Volume 31, Issue No.28Adherence to Direct Oral Anticoagulants in Patients With Non-valvular Atrial Fibrillation: A Single-Center Retrospective Study非瓣膜性心房颤动患者对直接口服抗凝药物的依从性：一项单中心回顾性研究DOI: 10.1177/10742484261490639 Appl Biochem Biotechnol IF: 03.300Volume 198, Issue 10No.29MAFB Overexpression in Macrophages Promotes Wound Healing in Diabetic Foot Ulcer by Transcriptionally Activating WDR74 to Drive a Tissue-Repair Phenotype and Suppress Inflammation and Oxidative Stress巨噬细胞中MAFB过表达通过转录激活WDR74驱动组织修复表型并抑制炎症和氧化应激促进糖尿病足溃疡伤口愈合DOI: 10.1007/s12010-026-05771-1 Advanced materials IF: 26.800Ahead of Print.No.30Engineered Extracellular Vesicle Revitalizing Macrophage Energy Metabolism for Aged Wound Repair工程化细胞外囊泡重振巨噬细胞能量代谢促进衰老伤口修复DOI: 10.1002/adma.75099 Journal of materials chemistry IF: 05.700Ahead of Print.No.31Orchestrating diabetic wound healing via MoS2 and Zn2+ integrated poly(vinyl alcohol)/dextran hydrogels: decoupling the efficacy-biosafety paradox in mild photothermal therapy通过MoS2与Zn2+整合的聚乙烯醇/葡聚糖水凝胶调控糖尿病伤口愈合：解耦温和光热疗法中的有效性-生物安全性悖论DOI: 10.1039/d6tb00971a Public health nursing IF: 01.300Ahead of Print.No.32The Impact of Physical Activity and Sedentary Behavior on Early Versus Late Readmission Among Patients With Diabetes体力活动与久坐行为对糖尿病患者早期与晚期再入院的影响DOI: 10.1111/phn.70189 Journal of Medical Biochemistry IF: 01.500Volume 45, Issue 3No.33A systematic review and meta-analysis and mendelian randomization analysis of serum phosphorus, albumin, and CRP as risk factors for death in hemodialysis patients血清磷、白蛋白和C反应蛋白作为血液透析患者死亡风险因素的系统评价、荟萃分析及孟德尔随机化分析DOI: 10.5937/jomb0-53079 Environ Health (Wash) IF: 06.300Volume 4, Issue 9No.34Socioeconomic Disparities in PFAS Exposure and Susceptibility to Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study中国成年人全氟和多氟烷基物质暴露与糖尿病易感性的社会经济差异：一项全国性横断面研究DOI: 10.1021/envhealth.6c00036 Bioactive materials IF: 20.300Volume 67, Issue No.35Zinc silicate microspheres-mediated bacterial metabolic interference and microenvironment remodeling for chronic wound repair硅酸锌微球介导细菌代谢干扰与微环境重塑促进慢性伤口修复DOI: 10.1016/j.bioactmat.2026.07.052 Journal of Medical Biochemistry IF: 01.500Volume 45, Issue 3No.36Risk correlation analysis of serum adiponectin (APN), D-dimer (DD) and the neutrophil - lymphocyte ratio (NLR) with the prognosis of diabetic foot ulcer infection血清脂联素、D-二聚体及中性粒细胞与淋巴细胞比值与糖尿病足溃疡感染预后的风险相关性分析DOI: 10.5937/jomb0-60169 Kidney international reports IF: 05.700Volume 11, Issue 11No.37Randomized Clinical Trials of Deutaleglitazar in Healthy Participants and in Patients with Diabetic Kidney DiseaseDeutaleglitazar在健康受试者和糖尿病肾病患者中的随机临床试验DOI: 10.1016/j.ekir.2026.107037 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.38Twenty-Four-Week UACR Response Trajectories and Clinical Correlates of Residual Albuminuria in Diabetic Kidney Disease During Finerenone Therapy: A Real-World Longitudinal Study非奈利酮治疗期间糖尿病肾脏病患者24周尿白蛋白与肌酐比值应答轨迹及残余白蛋白尿的临床相关因素：一项真实世界纵向研究DOI: 10.2147/DMSO.S638418 Advanced science IF: 14.100Ahead of Print.No.39A Metabolic-Epigenetic Axis of AARS1/IGF2BP3-K280 Lactylation Sustains Endometrial Cancer Stemness and RecurrenceAARS1/IGF2BP3-K280乳酸化修饰的代谢-表观遗传轴维持子宫内膜癌干性与复发DOI: 10.1002/advs.77757 Environ Health (Wash) IF: 06.300Volume 4, Issue 9No.40Gestational Low-Dose Bisphenol A Exposure Enhances Susceptibility to Metabolic Disorders in Adult Offspring Mice: Role of the Gut Microbiota-SCFAs-GPRs Axis妊娠期低剂量双酚A暴露增强成年子代小鼠代谢紊乱易感性：肠道菌群-短链脂肪酸-G蛋白偶联受体轴的作用DOI: 10.1021/envhealth.6c00171 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.41Berberine as a multitarget modulator of metabolic inflammation: molecular mechanisms, circadian regulation, and translational perspectives小檗碱作为代谢性炎症的多靶点调节剂：分子机制、昼夜节律调控与转化前景DOI: 10.3389/fphar.2026.1935151 Metab Syndr Relat Disord IF: 01.700Volume 24, Issue 9No.42The Mediating Role of Atherogenic Index of Plasma in the Association Between Dietary Inflammatory Index and Metabolic Syndrome: Evidence from NHANES and CHARLS血浆致动脉粥样硬化指数在膳食炎症指数与代谢综合征关联中的中介作用：来自NHANES和CHARLS的证据DOI: 10.1177/15578518261472829 Frontiers in immunology IF: 05.900Volume 17, Issue No.43The potential of platelet-rich plasma and PRP-derived biologics for neurological disorders: mechanisms and translational research富血小板血浆及其衍生生物制剂在神经系统疾病中的潜力：机制与转化研究DOI: 10.3389/fimmu.2026.1858720 FCVM IF: 02.900Volume 13, Issue No.44Case Report: Ischemic stroke revealing carotid fibromuscular dysplasia with multiple metabolic disturbances in a 42-year-old man病例报告：一例42岁男性以缺血性卒中为首发表现并伴多重心血管代谢异常的颈动脉肌纤维发育不良DOI: 10.3389/fcvm.2026.1828224 Journal of Medical Biochemistry IF: 01.500Volume 45, Issue 3No.45Variations and implications of Irisin, FGF-23, and N-MID osteocalcin in diabetic osteoporosis patients undergoing acarbose plus sitagliptin therapy: A prospective cohort analysis阿卡波糖联合西格列汀治疗糖尿病骨质疏松患者中鸢尾素、FGF-23和N-MID骨钙素的变化及意义：一项前瞻性队列分析DOI: 10.5937/jomb0-60451 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.46Endocrine crosstalk in cardiovascular-kidney-metabolic syndrome-related heart failure: the fibroblast growth factor 23-Klotho axis and cardiometabolic therapy心血管-肾脏-代谢综合征相关心力衰竭中的内分泌串扰：成纤维细胞生长因子23-Klotho轴与心脏代谢治疗DOI: 10.3389/fendo.2026.1933732 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.47Panax-derived ginsenosides in diabetes-associated cognitive dysfunction: mechanistic evidence and translational barriersPanax来源的人参皂苷在糖尿病相关认知功能障碍中的作用：机制证据与转化障碍DOI: 10.3389/fendo.2026.1965933 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.48Efficacy and safety of GLP-1RAs, SGLT2is, and nsMRAs for cardiovascular and renal outcomes in T2DM with CKD: a systematic review and network meta-analysisGLP-1受体激动剂、SGLT2抑制剂与非甾体类盐皮质激素受体拮抗剂对2型糖尿病合并慢性肾脏病患者心血管和肾脏结局的有效性与安全性：系统评价与网状Meta分析DOI: 10.3389/fendo.2026.1937754 Journal of Medical Biochemistry IF: 01.500Volume 45, Issue 3No.49Thyroid hormone sensitivity indices and hs-CRP as biochemical predictors of arteriovenous fistula maturation in diabetic nephropathy甲状腺激素敏感性指标与超敏C反应蛋白作为糖尿病肾病动静脉内瘘成熟的生化预测因子DOI: 10.5937/jomb0-61296 Journal of Medical Biochemistry IF: 01.500Volume 45, Issue 3No.50Correlation analysis of serum glycosylphosphatidylinositol mannosyltransferase 1 (GMP1) levels in type 2 diabetes mellitus patients2型糖尿病患者血清糖基磷脂酰肌醇甘露糖基转移酶1（GMP1）水平的相关性分析DOI: 10.5937/jomb0-60118 Front Cell Dev Biol IF: 04.300Volume 14, Issue No.51The CD39-CD73-adenosine axis: a pivotal regulator of retinal homeostasis and diseasesCD39-CD73-腺苷轴：视网膜稳态与疾病的关键调控因子DOI: 10.3389/fcell.2026.1893953 PeerJ IF: 02.400Volume 14, Issue No.52A retrospective study of correlation between insulin resistance surrogate indexes, inflammatory markers, and peripheral arterial disease in type 2 diabetes mellitus胰岛素抵抗替代指标和炎症标志物与2型糖尿病周围动脉疾病相关性的回顾性研究DOI: 10.7717/peerj.21743 Front Cell Dev Biol IF: 04.300Volume 14, Issue No.53Dynamic imbalance of mitochondria-associated ER membranes in cardiovascular disease: mechanisms, context dependence and therapeutic potential心血管疾病中线粒体相关内质网膜的动态失衡：机制、情境依赖性与治疗潜力DOI: 10.3389/fcell.2026.1931748 Food & function IF: 05.400Ahead of Print.No.54Inulin ameliorates sarcopenic obesity: critical roles of gut microbiota and bile acid metabolism菊粉改善肌少症性肥胖：肠道微生物群和胆汁酸代谢的关键作用DOI: 10.1039/d5fo05320j Obesity reviews IF: 07.400Ahead of Print.No.55Decoding Obesity Through the Lens of Adipose Tissue Inflammatory Regulation: A Comparative Study of Obesity Subtypes从脂肪组织炎症调控视角解读肥胖：肥胖亚型的比较研究DOI: 10.1111/obr.70232 Am J Physiol Endocrinol Metab IF: 03.100Ahead of Print.No.56Exercise-mimicking effect of exogenous lactate administration: Promoting visceral fat reduction via ventromedial hypothalamic SF-1 neurons in female rats外源性乳酸给药的运动模拟效应：通过雌性大鼠下丘脑腹内侧核SF-1神经元促进内脏脂肪减少DOI: 10.1152/ajpendo.00059.2026 Journal of inflammation research IF: 04.100Volume 19, Issue No.57Identification of Potential Key Biomarkers for Comorbid Depression and Obesity Through Integrated Bioinformatics Analysis and Experimental Verification通过整合生物信息学分析与实验验证识别抑郁症与肥胖症共病的潜在关键生物标志物DOI: 10.2147/JIR.S612567 Depression and anxiety IF: 03.300Volume 2026, Issue No.58Trends in Depression and Its Association With Gallstones: Evidence From NHANES With Exploration of Mediating Pathways抑郁的流行趋势及其与胆结石的关联：来自NHANES的证据及中介路径探索DOI: 10.1155/da/1800832 Journal of Medical Biochemistry IF: 01.500Volume 45, Issue 3No.59Biochemical and clinical effects of continuous positive airway pressure combined with sildenafil on inflammatory and hemodynamic profiles in obese asthma patients with pulmonary arterial hypertension持续气道正压通气联合西地那非对肥胖哮喘合并肺动脉高压患者炎症和血流动力学特征的生化及临床效应DOI: 10.5937/jomb0-62326 J Exerc Sci Fit IF: 03.500Volume 24, Issue 4No.60Reliability and validity of the International FItness Scale (IFIS): A systematic review and meta-analysis国际体能量表（IFIS）的信度与效度：系统综述与Meta分析DOI: 10.1016/j.jesf.2026.200501 Research IF: 08.500Volume 9, Issue No.61Association of Circadian Syndrome with Incident Risk of 23 Site-Specific Cancers: A Large-Scale Prospective Study in the UK Biobank昼夜节律综合征与23种特定部位癌症发病风险的关联：英国生物样本库大规模前瞻性研究DOI: 10.34133/research.1426 EClinicalMedicine IF: 10.000Volume 100, Issue No.62Association between early body weight reduction and treatment outcomes in participants with obstructive sleep apnoea and obesity: a post hoc analysis of SURMOUNT-OSA trials早期体重减轻与阻塞性睡眠呼吸暂停合并肥胖参与者治疗结局的关联：SURMOUNT-OSA试验的事后分析DOI: 10.1016/j.eclinm.2026.104203 Drug Des Devel Ther IF: 05.100Volume 20, Issue No.63Polygonatum odoratum (Mill.) Druce: A Review of Traditional Uses, Phytochemistry, Mass Spectrometric Fragmentation, Pharmacology, Toxicology, and Q-Marker Prediction玉竹：传统用途、植物化学、质谱裂解、药理学、毒理学及质量标志物预测综述DOI: 10.2147/DDDT.S631981 Frontiers in public health IF: 03.400Volume 14, Issue No.64Nutritional determinants, childhood morbidity patterns, and healthcare utilization among Chinese children: a population-based study中国儿童营养决定因素、儿童疾病模式与医疗服务利用：一项基于人群的研究DOI: 10.3389/fpubh.2026.1909080 Frontiers in nutrition IF: 05.100Volume 13, Issue No.65Association between abdominal obesity and cognitive outcomes in middle-aged adults: a systematic review腹型肥胖与中年成人认知结局之间的关联：一项系统综述DOI: 10.3389/fnut.2026.1879986 Photoacoustics IF: 06.800Volume 51, Issue No.66Photoacoustic and ultrasound Imaging of placental functions in gestational diabetes: From diagnosis to precision interventions妊娠期糖尿病胎盘功能的光声与超声成像：从诊断到精准干预DOI: 10.1016/j.pacs.2026.100881 The FASEB journal : IF: 04.200Volume 40, Issue 18No.67Metformin Inhibits Trophoblast Ferroptosis by Suppressing ATF2 and Activating the PI3K/Akt/Nrf2 Pathway to Improve Gestational Diabetes Mellitus二甲双胍通过抑制ATF2并激活PI3K/Akt/Nrf2通路抑制滋养细胞铁死亡改善妊娠期糖尿病DOI: 10.1096/fj.202602249RR Aging cell IF: 07.100Volume 25, Issue 10No.68Mitochondrial Fusion and Fission in Age-Related Cardio-Cerebral Diseases: Mechanisms and Interventions年龄相关心脑疾病中的线粒体融合与分裂：机制与干预DOI: 10.1111/acel.70729 Trop Anim Health Prod IF: 01.700Volume 58, Issue 8No.69Bovine appeasing pheromone mitigates long-distance transport stress to improve health and growth performance in beef cattle牛安抚信息素缓解长途运输应激以改善肉牛健康与生长性能DOI: 10.1007/s11250-026-05358-2 EMBO reports IF: 06.200Ahead of Print.No.70VGLL4 enhances PDK4 transcription and promotes metabolic dysfunction-associated fatty liver diseaseVGLL4增强PDK4转录并促进代谢功能障碍相关脂肪性肝病DOI: 10.1038/s44319-026-00934-x Journal of diabetes research IF: 03.400Volume 2026, Issue 1No.71TCM Constitution and the Risk of Hyperglycemia in Young and Middle-Aged Adults: A Retrospective Cohort Study中医体质与中青年高血糖风险：一项回顾性队列研究DOI: 10.1155/jdr/5548887 J Diabetes Investig IF: 03.000Ahead of Print.No.72Comment on "Frailty and low body mass index as key determinants of sodium-glucose cotransporter 2 inhibitor-specific adverse event-related discontinuation in adults aged ≥75 years: A multicenter real-world retrospective cohort study"对《衰弱与低体重指数是75岁及以上成人中钠-葡萄糖协同转运蛋白2抑制剂特异性不良事件相关停药的关键决定因素：一项多中心真实世界回顾性队列研究》的评论DOI: 10.1111/jdi.70444 Nature metabolism IF: 20.800Volume 8, Issue 9No.73m6A mRNA methylation regulates pancreatic α-cell plasticitym6A mRNA甲基化调控胰腺α细胞可塑性DOI: 10.1038/s42255-026-01591-z Frontiers in endocrinology IF: 04.600Volume 17, Issue No.74Associations of diabetes subgroups and lifestyle with incident dementia: insights from unsupervised phenotype clustering analysis糖尿病亚组和生活方式与痴呆发病的关联：来自无监督表型聚类分析的见解DOI: 10.3389/fendo.2026.1938222 Shengwu gongcheng xuebaoVolume 42, Issue 9No.75[Directed evolution of amine dehydrogenase for the catalytic resolution of (1R,5S)-3-ethylbicyclo [3.2.0] hept-3-en-6-one, a chiral intermediate of mirogabalin]胺脱氢酶定向进化用于催化拆分美洛加巴林手性中间体(1R,5S)-3-乙基双环[3.2.0]庚-3-烯-6-酮DOI: 10.13345/j.cjb.260241 Frontiers in nutrition IF: 05.100Volume 13, Issue No.76Association of healthy plant-based diet-lifestyle score with obesity-related cancer incidence and mortality: a prospective cohort study in the UK Biobank健康植物性饮食-生活方式评分与肥胖相关癌症发病率和死亡率的关联：英国生物样本库的前瞻性队列研究DOI: 10.3389/fnut.2026.1922232 International journal of obesity IF: 03.800Ahead of Print.No.77Revealing genetic foundations underlying cardiometabolic traits: integrating twin and GWAS data in Asian populations揭示心血管代谢性状的遗传基础：整合亚洲人群的双生子和全基因组关联研究数据DOI: 10.1038/s41366-026-02209-w J Thromb Thrombolysis IF: 02.200Ahead of Print.No.78miR-224-5p alleviates oxygen-glucose deprivation/reperfusion injury via regulating FASmiR-224-5p通过调控FAS减轻氧糖剥夺/复氧损伤DOI: 10.1007/s11239-026-03397-y 其他发布内容（224） More Published Articles Life sciences IF: 05.100Volume 404, Issue No.01Expression of Concern: Glycyrrhizin ameliorates high fat diet-induced obesity in rats by activating NrF2 pathway [Life Sci. 193 (2018) 159-170]关注声明：甘草酸通过激活NrF2通路改善高脂饮食诱导的大鼠肥胖 [Life Sci. 193 (2018) 159-170]DOI: 10.1016/j.lfs.2026.124675 BMJ open IF: 02.300Volume 16, Issue 9No.02Obesity among adults living in post-earthquake container settlements: a cross-sectional study in Malatya, Türkiye土耳其马拉蒂亚地震后集装箱安置点成年居民肥胖状况的横断面研究DOI: 10.1136/bmjopen-2026-122076 BMJ open IF: 02.300Volume 16, Issue 9No.03Prevalence and determinants of inadequate dietary diversity among 5-9 years old children in Bangladesh: findings from a nationally representative cross-sectional survey孟加拉国5-9岁儿童膳食多样性不足的患病率及其决定因素：来自全国代表性横断面调查的结果DOI: 10.1136/bmjopen-2026-117343 Appetite IF: 03.800Ahead of Print.No.04Normative values of the Three-Factor Eating Questionnaire -R18 in three Northern Finland cohort populations by sex and BMI classes三因素饮食问卷-R18在三个芬兰北部队列人群中按性别和BMI分类的常模值DOI: 10.1016/j.appet.2026.108794 Journal of ethnopharmacology IF: 05.400Ahead of Print.No.05Opuntia ficus-indica Ethanolic Extract Attenuates Lipopolysaccharide-Induced Inflammation in BALB/c MiceOpuntia ficus-indica乙醇提取物减轻BALB/c小鼠脂多糖诱导的炎症DOI: 10.1016/j.jep.2026.122411 Eur J Surg Oncol IF: 02.900Ahead of Print.No.06Sentinel lymph node mapping versus systematic lymphadenectomy in obese women undergoing minimally invasive surgery for endometrial cancer: A propensity-matched analysis肥胖子宫内膜癌患者微创手术中前哨淋巴结定位与系统性淋巴结清扫的比较：一项倾向性匹配分析DOI: 10.1016/j.ejso.2026.112161 Clinical radiology IF: 01.900Ahead of Print.No.07Single-slice quantitative magnetic resonance imaging (MRI) of the thigh for differential assessment of fasting-related body composition changes大腿单层定量磁共振成像（MRI）用于差异性评估禁食相关的身体成分变化DOI: 10.1016/j.crad.2026.107461 Ann Cardiol Angeiol (Paris)Ahead of Print.No.08[Predictive factors of recurrent acute coronary syndrome]复发性急性冠脉综合征的预测因素DOI: 10.1016/j.ancard.2026.102089 Zhonghua yixue zazhiVolume 106, Issue 36No.09[Expert consensus on the clinical application of continuous glucose monitoring in adult patients during the perioperative period (2026 edition)]成人围手术期持续葡萄糖监测临床应用专家共识（2026版）DOI: 10.3760/cma.j.cn112137-20260411-00984 Pediatrics IF: 06.400Ahead of Print.No.10Behavioral Interventions in Pediatric Type 1 Diabetes Management: An Updated Meta-Analysis儿科1型糖尿病管理中的行为干预：一项更新的Meta分析DOI: 10.1542/peds.2025-075333 Kidney international IF: 12.600Ahead of Print.No.11Results from the Phase 2 Explore-CKD Trial of lorundrostat, a novel aldosterone synthase inhibitor, in participants with uncontrolled hypertension, chronic kidney disease, and albuminurialorundrostat（一种新型醛固酮合酶抑制剂）在未控制高血压、慢性肾脏病和蛋白尿受试者中的2期Explore-CKD试验结果DOI: 10.1016/j.kint.2026.08.021 EJVES IF: 06.800Ahead of Print.No.12Predictors of Restenosis After Carotid Endarterectomy and Carotid Artery Stenting: A Single Centre Retrospective Cohort Study颈动脉内膜剥脱术与颈动脉支架植入术后再狭窄的预测因素：一项单中心回顾性队列研究DOI: 10.1016/j.ejvs.2026.09.042 AJOG IF: 08.400Ahead of Print.No.13Interpreting angiogenic biomarkers profiles in pregestational diabetes as markers of fetal risk (reply to letter-to-the-editor)解读孕前糖尿病中的血管生成生物标志物谱作为胎儿风险标志物（致编辑信回复）DOI: 10.1016/j.ajog.2026.09.030 Int J Infect Dis IF: 04.300Ahead of Print.No.14Integration of tuberculosis and diabetes mellitus care in health systems: a cross-sectional analysis of healthcare facilities in Lagos, Nigeria卫生系统中结核病与糖尿病护理的整合：尼日利亚拉各斯医疗机构横断面分析DOI: 10.1016/j.ijid.2026.109126 Survey of ophthalmology IF: 05.900Ahead of Print.No.15Incidence and characteristics of teprotumumab-associated ototoxicity in thyroid eye disease: A systematic review and meta-analysis甲状腺眼病中teprotumumab相关耳毒性的发生率与特征：系统综述与荟萃分析DOI: 10.1016/j.survophthal.2026.09.005 Journal of affective disorders IF: 04.900Ahead of Print.No.16Effects of transcendental meditation on mental health and work productivity among university staff in Australia: A randomised controlled trial超觉静坐对澳大利亚大学教职员工心理健康和工作生产力的影响：一项随机对照试验DOI: 10.1016/j.jad.2026.122555 Endocrine practice IF: 04.600Ahead of Print.No.17Remission or Reprieve? The Three Clocks of Type 2 Diabetes Remission缓解还是暂缓？2型糖尿病缓解的三个时钟DOI: 10.1016/j.eprac.2026.09.008 J Allergy Clin Immunol Pract IF: 06.600Ahead of Print.No.18Maternal asthma is associated with poor breastfeeding outcomes in early postpartum母亲哮喘与早期产后不良母乳喂养结局相关DOI: 10.1016/j.jaip.2026.09.007 Bone IF: 03.600Ahead of Print.No.19Revisiting drug guidelines for paediatric skeletal disorders: Implications for dental management重新审视儿童骨骼疾病用药指南：对牙科管理的启示DOI: 10.1016/j.bone.2026.118103 Bone IF: 03.600Ahead of Print.No.20Levothyroxine use and bone loss: Longitudinal analysis among euthyroid men and women from the Baltimore Longitudinal Study of Aging左甲状腺素使用与骨丢失：来自Baltimore Longitudinal Study of Aging的甲状腺功能正常男性和女性的纵向分析DOI: 10.1016/j.bone.2026.118100 Gen Comp Endocrinol IF: 01.700Ahead of Print.No.21In Memoriam: Dr. Tetsuya Hirano, 1938-2026悼念：平野哲也博士（1938-2026）DOI: 10.1016/j.ygcen.2026.115022 Advances in nutrition IF: 09.200Ahead of Print.No.22Toward International Dietary Guidance: A Food Guide Pyramid for Human and Planetary Health迈向国际膳食指南：面向人类与地球健康的食物指南金字塔DOI: 10.1016/j.advnut.2026.100738 J Foot Ankle Surg IF: 01.300Ahead of Print.No.23Artificial intelligence in foot and ankle surgery: Current applications, limitations and future directions人工智能在足踝外科中的应用：当前应用、局限性与未来方向DOI: 10.1053/j.jfas.2026.09.008 Prog Cardiovasc Dis IF: 07.600Ahead of Print.No.24Epicardial adipose tissue attenuation as an independent marker of cardiovascular outcomes in de novo heart failure (RECOVER-EAT)心外膜脂肪组织衰减作为新发心力衰竭心血管结局的独立标志物（RECOVER-EAT）DOI: 10.1016/j.pcad.2026.09.004 The Lancet Microbe IF: 20.400Ahead of Print.No.25Metabolism as a missing link between diabetes, tuberculosis, and drug resistance?代谢是糖尿病、结核病和耐药性之间缺失的环节？DOI: 10.1016/j.lanmic.2026.101523 Cell metabolism IF: 30.900Ahead of Print.No.26Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health脂肪组织ILC2依赖乙酰辅酶A羧化酶1维持代谢健康DOI: 10.1016/j.cmet.2026.08.019 Redox biology IF: 11.900Ahead of Print.No.27Antiglycation approach in selected autoimmune diseases: Where do we stand?抗糖化策略在特定自身免疫性疾病中的应用：现状如何？DOI: 10.1016/j.redox.2026.104410 J Nutr Health Aging IF: 04.000Ahead of Print.No.28Association of plasma growth differentiation factor 15 with wake after sleep onset in mild cognitive impairment血浆生长分化因子15与轻度认知障碍中入睡后觉醒的关联DOI: 10.1016/j.jnha.2026.100991 Public health IF: 03.200Ahead of Print.No.29Investigating the association between COVID-19 exposure and fetal and maternal health before public health vaccinations: A retrospective cohort study探究公共卫生疫苗接种前COVID-19暴露与胎儿及孕产妇健康之间的关联：一项回顾性队列研究DOI: 10.1016/j.puhe.2026.106446 BMJ open IF: 02.300Volume 16, Issue 9No.30From prescription to practice: a qualitative study of medication non-adherence in rural Tamil Nadu, India从处方到实践：印度泰米尔纳德邦农村地区药物不依从性的定性研究DOI: 10.1136/bmjopen-2026-118921 Kurume Medical JournalAhead of Print.No.31Metabolic Regulation of Body Size Determination by Genetic and Environmental Factors遗传和环境因素对体型决定的代谢调控DOI: 10.2739/kurumemedj.MS7312010 Endocrine journal IF: 02.100Ahead of Print.No.32Rapid progression of β-cell dysfunction in a patient with glycogen storage disease type 1a complicated by diabetes: longitudinal assessment by serial OGTTs with a review of the literature糖原贮积病1a型合并糖尿病患者β细胞功能障碍快速进展：系列OGTT纵向评估及文献综述DOI: 10.1507/endocrj.EJ26-0310 Internal medicine IF: 01.100Ahead of Print.No.33Lactic Acidosis and Inferior Epigastric Artery Hemorrhage Complicating Alcohol-Associated Cirrhosis and Pancreatic Diabetes: A Case Report酒精相关性肝硬化合并胰腺糖尿病并发乳酸酸中毒及腹壁下动脉出血：一例病例报告DOI: 10.2169/internalmedicine.8161-26 Obesity IF: 04.700Ahead of Print.No.34Protecting CEACAM1 Expression Prevents Diet-Induced Metabolic Dysfunction and Hepatic Fibrosis in Male Mice保护CEACAM1表达可预防雄性小鼠饮食诱导的代谢功能障碍和肝纤维化DOI: 10.1002/oby.70302 Kidney international IF: 12.600Ahead of Print.No.35Novel human neutralizing monoclonal antibodies against Pregnancy-Associated Plasma Protein A for the treatment of Autosomal Dominant Polycystic Kidney Disease新型人源中和性单克隆抗体靶向妊娠相关血浆蛋白A治疗常染色体显性多囊肾病DOI: 10.1016/j.kint.2026.08.020 Annals of anatomy IF: 01.700Ahead of Print.No.36Revisiting Culture Conditions of Satellite Cells In Vitro for Skeletal Muscle Regeneration and Therapeutic Applications重新审视卫星细胞体外培养条件用于骨骼肌再生与治疗应用DOI: 10.1016/j.aanat.2026.153381 Biochimie IF: 03.000Ahead of Print.No.37Apolipoprotein D modulates obesity-linked inflammation and metabolic syndrome development in a sex dependent manner载脂蛋白D以性别依赖的方式调节肥胖相关炎症和代谢综合征的发展DOI: 10.1016/j.biochi.2026.09.008 Journal of lipid research IF: 04.100Ahead of Print.No.38Prohibitin-1 cysteine-69 plays a sex-dependent role in fatty acid metabolismProhibitin-1半胱氨酸-69在脂肪酸代谢中发挥性别依赖性作用DOI: 10.1016/j.jlr.2026.101158 JMIR research protocols IF: 01.500Volume 15, Issue No.39Preliminary Examination of an Innovative mHealth-Based Dietary Fiber Intervention to Improve Outcomes in Young Adults With Prediabetes: Protocol for a Single-Arm Feasibility Study基于移动健康的膳食纤维干预改善糖尿病前期年轻成人结局的初步检验：单臂可行性研究方案DOI: 10.2196/97873 EBioMedicine IF: 10.800Ahead of Print.No.40Metabolomic profiling of ultra-processed food consumption and cardiovascular risk in Spanish preschool children: a cross-sectional study西班牙学龄前儿童超加工食品消费与心血管风险的代谢组学特征：一项横断面研究DOI: 10.1016/j.ebiom.2026.106488 European respiratory review IF: 10.400Volume 35, Issue 181No.41Pulmonary arterial hypertension with signs of venous/capillary involvement in connective tissue diseases: paradigms and paradoxes结缔组织病相关肺动脉高压伴静脉/毛细血管受累征象：范式与悖论DOI: 10.1183/16000617.0159-2026 The journal of immunology IF: 03.400Volume 215, Issue 9No.42Prostaglandin D2 production in obese mice is associated with reduced lung inflammation and improved control of Francisella tularensis and Bordetella pertussis infection肥胖小鼠中前列腺素D2的产生与肺部炎症减轻及对土拉弗朗西斯菌和百日咳鲍特菌感染控制改善相关DOI: 10.1093/jimmun/vkag254 Z Gastroenterol IF: 01.600Volume 64, Issue 9No.43The new TRR 412 Metabolic Dysfunction-Associated Steatotic Liver Disease: From Pathophysiological Mechanisms to Translation into Tailored Therapeutic Concepts (Berlin / Dresden)新TRR 412代谢功能障碍相关脂肪性肝病：从病理生理机制到转化为定制治疗概念（柏林/德累斯顿）DOI: 10.1055/a-2890-7253 Z Gastroenterol IF: 01.600Volume 64, Issue 9No.44[New Therapeutic Approaches for MASH: Mechanisms and Clinical Promise]MASH的新治疗途径：机制与临床前景DOI: 10.1055/a-2894-7716 Zhonghua yixue zazhiVolume 106, Issue 36No.45[Expert insights on clinical application of immunotherapy for type 1 diabetes mellitus (2026 edition)]1型糖尿病免疫治疗临床应用专家见解（2026版）DOI: 10.3760/cma.j.cn112137-20260617-01569 Clinics in dermatology IF: 02.200Ahead of Print.No.46GLP-1 Receptor Agonists in Dermatology: Prescribing Frameworks, Access, and the Emerging PipelineGLP-1受体激动剂在皮肤科中的应用：处方框架、可及性与新兴研发管线DOI: 10.1016/j.clindermatol.2026.09.018 Xenotransplantation IF: 04.100Volume 33, Issue 5No.47Flow Cytometric Immune Profiling Enables Early Detection of Rejection in Islet Xenotransplantation流式细胞术免疫分析可实现胰岛异种移植排斥的早期检测DOI: 10.1111/xen.70170 Prog Cardiovasc Dis IF: 07.600Ahead of Print.No.48Back to the future: Revisiting "leave nothing behind" when managing coronary artery disease回到未来：重新审视冠状动脉疾病管理中的“不留置任何东西”策略DOI: 10.1016/j.pcad.2026.09.008 Survey of ophthalmology IF: 05.900Ahead of Print.No.49Effect of systemic fibrates on diabetic retinopathy prevention and progression: A comprehensive systematic review and meta-analysis全身性贝特类药物对糖尿病视网膜病变预防和进展的影响：一项全面的系统综述和荟萃分析DOI: 10.1016/j.survophthal.2026.09.006 British Medical Journal IF: 42.700Volume 394, Issue No.50Renal outcomes in people with type 2 diabetes with and without albuminuria treated with SGLT-2 inhibitors and GLP-1 receptor agonists: target trial emulation接受SGLT-2抑制剂和GLP-1受体激动剂治疗的伴或不伴白蛋白尿的2型糖尿病患者的肾脏结局：目标试验模拟DOI: 10.1136/bmj-2026-100574 Cell host & microbe IF: 18.700Ahead of Print.No.51A commensal-derived sugar protects against obesity by regulating immunometabolism一种共生菌来源的糖通过调节免疫代谢预防肥胖DOI: 10.1016/j.chom.2026.08.018 British Medical Journal IF: 42.700Volume 394, Issue No.52Contemporary menopausal hormone therapy and thrombotic disease: nationwide nested case-control study当代绝经激素治疗与血栓性疾病：全国性巢式病例对照研究DOI: 10.1136/bmj-2026-100688 Ultrasound in medicine & biology IF: 02.600Ahead of Print.No.53Detection of Osteoporotic Changes in Rat Femoral Bone Using the Acoustically Stimulated Electromagnetic (ASEM) Method利用声刺激电磁（ASEM）方法检测大鼠股骨骨质疏松性变化DOI: 10.1016/j.ultrasmedbio.2026.08.019 Contemporary clinical trials IF: 01.900Ahead of Print.No.54Impact of aquatic versus land exercise on glycated hemoglobin and blood pressure in older adults with multimorbidity: A randomized controlled trial protocol水中运动与陆地运动对多重慢性病老年人糖化血红蛋白和血压的影响：一项随机对照试验方案DOI: 10.1016/j.cct.2026.108481 J Gastrointest Surg IF: 02.400Ahead of Print.No.55Prediction analysis for delayed discharge following gastric bypass surgery胃旁路手术后延迟出院的预测分析DOI: 10.1016/j.gassur.2026.102608 Z Gastroenterol IF: 01.600Volume 64, Issue 9No.56Metabolic and Bariatric Surgery as a Therapeutic Option for MASLD: Outcome, Mechanism, and Long-Term Implications减重手术作为脂肪性肝病的治疗选择：结局、机制与长期意义DOI: 10.1055/a-2927-4771 Z Gastroenterol IF: 01.600Volume 64, Issue 9No.57MASLD: Established Knowledge and Emerging Directions - Guideline UpdatesMASLD：既定知识与新兴方向——指南更新DOI: 10.1055/a-2894-7628 Clinical nutrition IF: 07.400Ahead of Print.No.58How diet-related follow-up period affects risk of adverse health outcomes饮食相关随访期如何影响不良健康结局风险DOI: 10.1016/j.clnu.2026.106784 JCH IF: 02.500Volume 28, Issue 9No.59Blood Pressure Phenotypes in Patients Recently Diagnosed With Type 2 Diabetes Mellitus and Matched Controls: A Study in Urban Mozambique新诊断2型糖尿病患者与匹配对照者的血压表型：莫桑比克城市地区研究DOI: 10.1111/jch.70356 Cardiovascular Diabetology IF: 10.600Volume 25, Issue 1No.60Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0–3: a nationwide prospective cohort study甘油三酯-葡萄糖指数与非传统血脂指标的前期、标志点和两次访视累积测量与心血管-肾脏-代谢综合征（CKM）0-3期成人新发心血管疾病的关系：一项全国性前瞻性队列研究DOI: 10.1186/s12933-026-03386-8 Cardiovascular Diabetology IF: 10.600Ahead of Print.No.61Association of lipid-frailty composite indices with cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: evidence from the UK Biobank and CHARLS脂质-衰弱复合指数与心血管-肾脏-代谢综合征0-3期个体心血管疾病风险的关联：来自英国生物样本库和CHARLS的证据DOI: 10.1186/s12933-026-03362-2 European Heart Journal IF: 35.600Ahead of Print.No.62Semaglutide mechanisms of action: the missing pieces司美格鲁肽的作用机制：缺失的拼图DOI: 10.1093/eurheartj/ehag602 NEJM IF: 78.500Volume 395, Issue 12No.63Clinical Uses of Common Genetic Variants Associated with Common Diseases常见疾病相关常见遗传变异的临床应用DOI: 10.1056/NEJMra2413201 Medwave IF: 01.200Volume 26, Issue 8No.64Post-COVID symptoms prevalence, latent class pattern, and functional impact: A population-based cross-sectional study in two Chilean cities, 2024COVID-19后症状的患病率、潜在类别模式及功能影响：2024年智利两个城市基于人群的横断面研究DOI: 10.5867/medwave.2026.08.3234 J Bone Miner Res IF: 05.900Ahead of Print.No.65Real-World Effectiveness of Burosumab Versus Oral Phosphate and Active Vitamin D in Adults with X-Linked Hypophosphatemia (XLH): A 3-Year Follow-Up of the XLH Disease Monitoring Program布罗索尤单抗与口服磷酸盐联合活性维生素D在成人X连锁低磷血症（XLH）中的真实世界有效性：XLH疾病监测计划的3年随访DOI: 10.1093/jbmr/zjag136 Science advances IF: 12.500Volume 12, Issue 39No.66The hidden cost of positivity: Ensuring integrity in scientific research积极性的隐藏成本：确保科学研究的诚信DOI: 10.1126/sciadv.ael2131 Science advances IF: 12.500Volume 12, Issue 39No.67Social Physiology: Human homeostasis is more efficient in social proximity社会生理学：人类在社交接近状态下的稳态调节更高效DOI: 10.1126/sciadv.aeg4937 Intervirology IF: 01.800Ahead of Print.No.68HUMAN PAPILLOMAVIRUS GENOTYPE DISTRIBUTION AMONG ADULT WOMEN IN THE RABAT REGION (MOROCCO): A RETROSPECTIVE AND ANALYTICAL STUDY WITH IMPLICATIONS FOR HPV VACCINATION STRATEGIES摩洛哥拉巴特地区成年女性人乳头瘤病毒基因型分布：一项回顾性分析研究及其对HPV疫苗接种策略的启示DOI: 10.1159/int/adgag002 J Am Podiatr Med Assoc IF: 00.600Volume 116, Issue 5No.69Correction: Turemis et al. Comparison of Single and Multiple Toe Amputations in Diabetic Patients with Long-Term Follow-Up and Evaluation of Reamputation Risk. J. Am. Podiatr. Med. Assoc. 2025, 115, 23216更正：Turemis等。糖尿病患者单趾与多趾截肢的长期随访比较及再截肢风险评估。J. Am. Podiatr. Med. Assoc. 2025, 115, 23216DOI: 10.3390/japma116050057 Audiology researchVolume 16, Issue 5No.70Hearing Health Monitoring in Adults Living with Diabetes: A Scoping Review to Inform Integrated Care Pathways成人糖尿病患者听力健康监测：为整合照护路径提供依据的范围综述DOI: 10.3390/audiolres16050134 Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 39No.71Neonatal enteric infection disrupts the microbiota-gut-brain axis through pattern recognition receptors and altered neuroimmune signaling新生儿肠道感染通过模式识别受体和改变的神经免疫信号破坏微生物群-肠-脑轴DOI: 10.1073/pnas.2606222123 Geriatrics IF: 02.100Volume 11, Issue 5No.72A Scoping Review of Integrated Care Models for Managing Depression in Older Adults老年抑郁症管理整合照护模式的范围综述DOI: 10.3390/geriatrics11050126 Geriatrics IF: 02.100Volume 11, Issue 5No.73Long-Term Survival of Very Elderly Patients with Heart Failure Managed in a Comprehensive Heart Failure Management Unit在综合心力衰竭管理单元中管理的超高龄心力衰竭患者的长期生存DOI: 10.3390/geriatrics11050119 Methods and protocols IF: 02.000Volume 9, Issue 5No.74Gradient-Free Isolation of Murine Pancreatic Islets for Single-Cell RNA Sequencing用于单细胞RNA测序的小鼠胰岛无梯度分离方法DOI: 10.3390/mps9050136 Journal of behavioral medicine IF: 02.900Ahead of Print.No.75Associations between intuitive eating and health behaviors and physical health in U.S. adults直觉饮食与美国成年人健康行为及身体健康之间的关联DOI: 10.1007/s10865-026-00712-z Probiotics Antimicrob Proteins IF: 04.400Ahead of Print.No.76Selective α-Amylase Inhibition by Plant Defensins: Structural Determinants, Engineering Strategies, and Translational Prospects植物防御素对α-淀粉酶的选择性抑制：结构决定因素、工程策略及转化前景DOI: 10.1007/s12602-026-11216-2 Molecular biology reports IF: 02.800Volume 53, Issue 1No.77Inflammasome-derived biomarkers in wound healing: linking tissue repair, chronic inflammation, fibrosis, and precision therapeutics伤口愈合中的炎症小体衍生生物标志物：连接组织修复、慢性炎症、纤维化与精准治疗DOI: 10.1007/s11033-026-12783-x Diabetes care IF: 16.600Ahead of Print.No.78Effective Sulfonylurea-Sparing First-Line HNF4A-MODY Therapy With Sodium-Dependent Glucose Cotransporter 2 Inhibitors钠-葡萄糖协同转运蛋白2抑制剂作为有效的一线HNF4A-MODY疗法并可减少磺脲类药物用量DOI: 10.2337/dc26-1631 Infectious disease reportsVolume 18, Issue 5No.79The Role of Infrared Thermography in the Diagnosis and Monitoring of Diabetic Foot Infection: A Systematic Review红外热成像在糖尿病足感染诊断和监测中的作用：一项系统综述DOI: 10.3390/idr18050098 Advances in therapy IF: 04.000Ahead of Print.No.80Comparative Effectiveness of Once-Weekly Semaglutide Versus Sulfonylureas, DPP4 Inhibitors, and Thiazolidinediones in Patients with Type 2 Diabetes and Chronic Kidney Disease每周一次司美格鲁肽对比磺脲类、DPP4抑制剂和噻唑烷二酮类药物在2型糖尿病合并慢性肾脏病患者中的比较有效性DOI: 10.1007/s12325-026-03744-8 Laboratory medicine IF: 01.000Volume 57, Issue 5No.81Combined total error in calculated clinical chemistry tests: component analytical error is magnified and decision threshold gray zones widen计算型临床化学检测中的组合总误差：组分分析误差被放大且决策阈值灰区增宽DOI: 10.1093/labmed/lmag068 Antibodies IF: 02.700Volume 15, Issue 5No.82Antibody-Based Biologics for CNS Disorders用于中枢神经系统疾病的抗体类生物制剂DOI: 10.3390/antib15050086 Geriatrics IF: 02.100Volume 11, Issue 5No.83A Patient- and Function-Centric Model/Approach for Hypoglycemia Management in Older Adults以患者和功能为中心的老年人低血糖管理模式/方法DOI: 10.3390/geriatrics11050118 Bull Exp Biol Med IF: 00.600Ahead of Print.No.84Spatiotemporal Dynamics of Bihormonal Cells in the Developing Human Pancreas发育中人类胰腺双激素细胞的时空动态DOI: 10.1007/s10517-026-06733-7 Diabetologia IF: 10.200Ahead of Print.No.85Insulin pens and the digital ecosystem胰岛素笔与数字生态系统DOI: 10.1007/s00125-026-06858-4 JMIR medical informatics IF: 03.800Volume 14, Issue No.86Multioutput Machine Learning Model for Predicting Postoperative Outcomes After Liposuction: Algorithm Development and Validation Study in a Multicenter Cohort多输出机器学习模型预测抽脂术后结局：多中心队列中的算法开发与验证研究DOI: 10.2196/82145 Turkish Journal of pediatrics IF: 00.800Volume 68, Issue 4No.87Growth and development in children with periodic fever, aphthous stomatitis, pharyngitis, lymphadenitis syndrome: a case-control study周期性发热、阿弗他口炎、咽炎、淋巴结炎综合征患儿的生长发育：一项病例对照研究DOI: 10.24953/turkjpediatr.2026.6925 Turkish Journal of pediatrics IF: 00.800Volume 68, Issue 4No.88Relationship between obesity, digital game addiction, and sleep quality in secondary school students: a cross-sectional study中学生肥胖、数字游戏成瘾与睡眠质量之间的关系：一项横断面研究DOI: 10.24953/turkjpediatr.2026.8311 EJPC IF: 07.500Ahead of Print.No.89Microbiome-Targeted Interventions for Early Cardiometabolic Prevention: A Systematic Review and Meta-Analysis in Children and Adolescents针对早期心血管代谢预防的微生物组靶向干预：儿童和青少年的系统综述与荟萃分析DOI: 10.1093/eurjpc/zwag500 PLOS global public health IF: 02.500Volume 6, Issue 9No.90Metabolic health and cardiovascular risk among Cameroonian adults with and without obesity喀麦隆成人肥胖与非肥胖人群的代谢健康与心血管风险DOI: 10.1371/journal.pgph.0006870 Hematology reportsVolume 18, Issue 5No.91Steatotic Liver Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Case Series and Literature Review异基因造血干细胞移植受者中的脂肪性肝病：病例系列及文献综述DOI: 10.3390/hematolrep18050065 Epidemiologia IF: 02.200Volume 7, Issue 5No.92Overweight and Obesity and Their Association with Neurodevelopmental Delay Among Preschoolers学龄前儿童超重和肥胖与神经发育迟缓的关联DOI: 10.3390/epidemiologia7050128 Epidemiologia IF: 02.200Volume 7, Issue 5No.93Associations Among Demographic Factors, Bullying, Victimization and Weight Status Among Children with and Without Current Autism Spectrum Disorder Using the National Survey of Children's Health基于National Survey of Children's Health的当前自闭症谱系障碍与非自闭症谱系障碍儿童中人口学因素、欺凌、受害与体重状况之间的关联DOI: 10.3390/epidemiologia7050121 Journal of Hypertension IF: 04.100Ahead of Print.No.94Maternal macrovascular and microvascular adaptation in healthy pregnancy, gestational diabetes, and hypertensive disorders of pregnancy健康妊娠、妊娠期糖尿病及妊娠期高血压疾病中的母体大血管与微血管适应DOI: 10.1097/HJH.0000000000004414 GeroScience IF: 05.400Volume 48, Issue 5No.95Epigenetic aging biomarkers in dietary geroscience: feasibility, participant perceptions, and trial design considerations膳食老年科学中的表观遗传衰老生物标志物：可行性、参与者认知与试验设计考量DOI: 10.1007/s11357-026-02443-0 Geriatrics IF: 02.100Volume 11, Issue 5No.96Real-World Long-Term Safety of Statin-Fibrate Combination Therapy in Older Patients (≥75 Years): A European Cohort Analysis他汀类-贝特类联合治疗在老年患者（≥75岁）中的真实世界长期安全性：一项欧洲队列分析DOI: 10.3390/geriatrics11050135 Kidney360 IF: 03.000Ahead of Print.No.97Prevalence of Undertreated CKD among Hospital Inpatients: A Prospective Cross-Sectional Study住院患者中未充分治疗CKD的患病率：一项前瞻性横断面研究DOI: 10.34067/KID.0000001323 Pediatric reportsVolume 18, Issue 5No.98Long-Term Sequelae in Patients Treated for Recurrent CNS Relapses of Pediatric B-Cell Acute Lymphoblastic Leukemia: 20-Year Follow-Up, Neurological Consequences, and Survivorship Burden-A Case Report and Literature Review儿童B细胞急性淋巴细胞白血病复发性中枢神经系统复发治疗后的长期后遗症：20年随访、神经系统后果与生存负担——病例报告及文献综述DOI: 10.3390/pediatric18050121 Advances in Respiratory Medicine IF: 02.300Volume 94, Issue 5No.99Gastroesophageal Reflux Burden Before and After Exercise Challenge in Children with Poorly Controlled Asthma: A 48-Hour MII-pH Study控制不佳哮喘儿童运动激发试验前后的胃食管反流负担：一项48小时MII-pH研究DOI: 10.3390/arm94050066 Advances in Respiratory Medicine IF: 02.300Volume 94, Issue 5No.100Patterns of Comorbidity in Asthma-COPD Overlap Cohort According to Various ACO Definitions不同ACO定义下哮喘-慢阻肺重叠队列的共病模式DOI: 10.3390/arm94050062 J Immigr Minor Health IF: 01.800Ahead of Print.No.101Nutritional Vulnerabilities and Dietary Disparities Among Migrant Workers in the Informal Sectors: A Global Scoping Review非正规部门 migrant workers 的营养脆弱性与饮食差异：一项全球范围综述DOI: 10.1007/s10903-026-02003-w JAMA Network Open IF: 09.700Volume 9, Issue 9No.102Presumed Intraductal Papillary Mucinous Neoplasms in Individuals at High Risk for Pancreatic Cancer胰腺癌高危人群中的疑似导管内乳头状黏液性肿瘤DOI: 10.1001/jamanetworkopen.2026.35610 PLoS medicine IF: 09.900Volume 23, Issue 9No.103The effect of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis生活方式干预对多内分泌代谢性卵巢综合征女性的效果：系统评价与荟萃分析DOI: 10.1371/journal.pmed.1004887 Nutrition reviews IF: 04.900Ahead of Print.No.104Dietary Interventions for Metabolic Dysfunction-Associated Steatotic Liver Disease in Children and Adolescents: A Network Meta-Analysis of Randomized Clinical Trials儿童和青少年代谢功能障碍相关脂肪性肝病的饮食干预：随机临床试验的网络荟萃分析DOI: 10.1093/nutrit/nuag135 Science translational medicine IF: 14.600Volume 18, Issue 868No.105Preclinical and clinical evaluation of systemic danegaptide for the treatment of nonproliferative diabetic retinopathy全身性danegaptide治疗非增殖性糖尿病视网膜病变的临床前与临床评价DOI: 10.1126/scitranslmed.aed8692 Vision IF: 01.800Volume 10, Issue 4No.106Diabetic Eye Screening Attendance Among Minority Ethnic and Other Inequality-Affected Populations in the United Kingdom: A Systematic Review of Associated Factors, Barriers, Facilitators and Interventions英国少数族裔及其他受不平等影响人群的糖尿病眼病筛查参与情况：相关因素、障碍、促进因素及干预措施的系统综述DOI: 10.3390/vision10040066 Endocrinol Diabetes Metab Case Rep IF: 00.700Volume 2026, Issue 3No.107Primary hyperaldosteronism in patient with Bardet-Biedl syndrome: unmasking secondary hypertensionBardet-Biedl综合征患者中的原发性醛固酮增多症：揭示继发性高血压DOI: 10.1530/EDM-25-0193 Neurology IF: 08.500Volume 107, Issue 8No.108Stroke in the Young: Incidence, 30-Day Case Fatality Rates, and Risk Factors Over Time in a Population-Based Study青年卒中：基于人群研究的发病率、30天病死率及危险因素随时间变化趋势DOI: 10.1212/WNL.0000000000218622 J Am Podiatr Med Assoc IF: 00.600Volume 116, Issue 5No.109Incidence and Hospitalization Costs of Lower Extremity Amputations in Patients with Diabetes During 2015-2020: A Regional Retrospective Observational Study from Sweden2015-2020年糖尿病患者下肢截肢的发生率和住院费用：来自瑞典的区域性回顾性观察研究DOI: 10.3390/japma116050066 Advances in Respiratory Medicine IF: 02.300Volume 94, Issue 5No.110Precision Medicine in Overlap Syndrome (COPD-Obstructive Sleep Apnea): From Phenotypes and Endotypes to Treatable Traits重叠综合征（慢性阻塞性肺疾病-阻塞性睡眠呼吸暂停）的精准医学：从表型、内型到可治疗特征DOI: 10.3390/arm94050063 Journal of neuro-oncology IF: 03.100Volume 179, Issue 3No.111Post-operative day one discharge following craniotomy for tumour resection肿瘤切除开颅术后第一天出院DOI: 10.1007/s11060-026-05790-2 Metabolic brain disease IF: 03.500Volume 41, Issue 1No.112Behavioral, neuroanatomic, and neuroinflammatory characteristics of metabolic syndrome in cafeteria diet-induced obese male rats自助餐厅饮食诱导的肥胖雄性大鼠代谢综合征的行为、神经解剖和神经炎症特征DOI: 10.1007/s11011-026-01989-4 JAMA IF: 55.000Ahead of Print.No.113Lifestyle Modification and Incretin Therapy for Individuals With Obesity—Reply肥胖患者的体力活动调整与肠促胰岛素治疗——回复DOI: 10.1001/jama.2026.14700 JAMA IF: 55.000Ahead of Print.No.114Lifestyle Modification and Incretin Therapy for Individuals With Obesity肥胖患者的生活方式调整与肠促胰岛素治疗DOI: 10.1001/jama.2026.14697 Med J Armed Forces IndiaVolume 82, Issue 5No.115Association of rs429358 and rs7412 polymorphism in apolipoprotein E gene with the severity of neuropathy among type 2 diabetes patients载脂蛋白E基因rs429358和rs7412多态性与2型糖尿病患者神经病变严重程度的关联DOI: 10.1016/j.mjafi.2025.12.003 BJCVS IF: 01.200Volume 41, Issue 3No.116Postoperative Acute Kidney Injury in Cardiovascular Surgery Patients with Prolonged Intensive Care Unit Stay: Impact on Mortality and Outcomes心血管手术患者延长重症监护病房停留时间后术后急性肾损伤对死亡率和结局的影响DOI: 10.21470/1678-9741-2025-0271 Therapeutic drug monitoring IF: 02.400Ahead of Print.No.117Use of Two Biologics During Pregnancy: Infliximab and Vedolizumab: A Case Study妊娠期使用两种生物制剂：Infliximab与Vedolizumab：一例病例研究DOI: 10.1097/FTD.0000000000001519 FEMS microbiology reviews IF: 12.300Ahead of Print.No.118Plasma-activated water: A dual-action disinfectant and wound-healing therapy for diabetes-related foot infections等离子体活化水：针对糖尿病相关足部感染的双重作用消毒与伤口愈合疗法DOI: 10.1093/femsre/fuag051 Chronic illness IF: 01.800Ahead of Print.No.119Social support mediates relationship between death anxiety and stress in chronic illness社会支持在慢性疾病中死亡焦虑与压力关系间的中介作用DOI: 10.1177/17423953261491389 Endocr Metab Immune Disord Drug Targets IF: 02.000Volume 26, Issue No.120The Proof of Variant m.3243A>G does not Necessarily Mean MELASm.3243A>G变异阳性并不一定意味着MELASDOI: 10.2174/0118715303487861260523100425 Nutrición hospitalaria IF: 01.100Ahead of Print.No.121Impact of chronic diseases and associated medications on thiamine metabolism in the non-demented elderly慢性疾病及其相关药物对非痴呆老年人硫胺素代谢的影响DOI: 10.20960/nh.06369 Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.122Temporal Dynamics of Urinary Extracellular Vesicle Excretion and Cargo in Healthy Subjects over 24 Hours健康受试者24小时内尿液细胞外囊泡排泄与货物的时间动态DOI: 10.1152/ajprenal.00129.2026 Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 6No.123Diabetic Foot Syndrome: A Paradigm of Complexity and a Call for Comprehensive Ownership by the Diabetologists糖尿病足综合征：复杂性的典范与糖尿病专科医生全面负责的呼吁DOI: 10.1002/dmrr.70234 Curēus IF: 01.300Volume 18, Issue 8No.124Refractory Graves' Disease With Propylthiouracil-Induced Hemophagocytic Lymphohistiocytosis and Multiple Drug Allergies Treated With Total Thyroidectomy: A Case Report难治性Graves病伴丙硫氧嘧啶诱导的噬血细胞性淋巴组织细胞增生症及多种药物过敏经全甲状腺切除术治疗：一例病例报告DOI: 10.7759/cureus.115040 J Multidiscip Healthc IF: 02.400Volume 19, Issue No.125An Evaluation of Digital Health Tools to Support Multidisciplinary Teams in Managing Patients with Type 2 Diabetes数字健康工具支持多学科团队管理2型糖尿病患者的评估DOI: 10.2147/JMDH.S571579 Journal of Medical Biochemistry IF: 01.500Volume 45, Issue 3No.126The importance of elevated basal 17-hydroxyprogesterone in the diagnosis of children with congenital adrenal hyperplasia基础17-羟孕酮升高在先天性肾上腺皮质增生症患儿诊断中的重要性DOI: 10.5937/jomb0-54426 Curēus IF: 01.300Volume 18, Issue 9No.127Impact of Premorbid Function and Comorbidities in Geriatric Traumatic Brain Injury Patients: A Systematic Review病前功能与合并症对老年创伤性脑损伤患者的影响：一项系统综述DOI: 10.7759/cureus.116746 J Shoulder Elb ArthroplastVolume 10, Issue 4No.128Pre-operative narcotic use is associated with worse outcomes following primary anatomic and reverse shoulder arthroplasty术前麻醉药品使用与初次解剖型和反式肩关节置换术后更差结局相关DOI: 10.1016/j.jsea.2026.100079 Clin Gastroenterol Hepatol IF: 12.000Ahead of Print.No.129AGA Clinical Practice Update on the Evaluation and Management of Metabolic Dysfunction- and Alcohol-Associated Liver Disease: Expert ReviewAGA临床实践更新：代谢功能障碍和酒精相关肝病的评估与管理专家综述DOI: 10.1016/j.cgh.2026.07.027 Arthrosc Sports Med RehabilAhead of Print.No.130Indices of Systemic Inflammation Are Elevated in Women With Evidence of Metabolic Syndrome After Anterior Cruciate Ligament Reconstruction前交叉韧带重建术后存在代谢综合征证据的女性全身炎症指标升高DOI: 10.1002/ars2.70091 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.131Diabetic kidney disease within the framework of cardio-kidney-metabolic health: a paradigm shift心血管-肾脏-代谢健康框架下的糖尿病肾脏病：范式转变DOI: 10.3389/fphar.2026.1907928 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.132Non-albumin proteinuria as a candidate biomarker of treatment response to finerenone in diabetic kidney disease: a real-world cohort study非白蛋白尿作为糖尿病肾脏病中非奈利酮治疗反应的候选生物标志物：一项真实世界队列研究DOI: 10.3389/fendo.2026.1918192 Gut microbes IF: 11.000Volume 18, Issue 1No.133A probiotic Bifidobacterium pseudocatenulatum converts hesperidin to bioactive hesperetin and improves metabolic dysfunction in aging mice一种益生菌假小链双歧杆菌将橙皮苷转化为生物活性橙皮素并改善衰老小鼠的代谢功能障碍DOI: 10.1080/19490976.2026.2736902 Journal of Hypertension IF: 04.100Ahead of Print.No.134Serum fatty acid profile and desaturase activity in hypertensive patients with and without metabolic syndrome伴有和不伴有代谢综合征的高血压患者的血清脂肪酸谱和去饱和酶活性DOI: 10.1097/HJH.0000000000004398 Journal of patient safety IF: 01.700Ahead of Print.No.135Reducing Insulin Self-Administration Errors in Adults With Diabetes: A Quasi-Experimental Study of a Structured Intervention减少成人糖尿病患者胰岛素自我注射错误：一项结构化干预的准实验研究DOI: 10.1097/PTS.0000000000001595 Circ Arrhythm Electrophysiol IF: 09.800Ahead of Print.No.136PFKFB2 Gates a Relationship Between Cardiac Glycolytic Regulation and Electrophysiological FunctionPFKFB2 调控心脏糖酵解调节与电生理功能之间的关系DOI: 10.1161/CIRCEP.126.014860 Curēus IF: 01.300Volume 18, Issue 8No.137Efficacy of Automated Insulin Delivery Systems in Pediatric Type 1 Diabetes: A Systematic Review of Randomized Controlled Trials自动化胰岛素输送系统在儿童1型糖尿病中的有效性：随机对照试验的系统综述DOI: 10.7759/cureus.115014 iScience IF: 04.100Volume 29, Issue 10No.138Insulin receptor signaling in gustatory cells suppresses sugar taste sensitivity and feeding in Drosophila果蝇味觉细胞中的胰岛素受体信号抑制糖味觉敏感性和进食DOI: 10.1016/j.isci.2026.117524 Frontiers in veterinary science IF: 02.900Volume 13, Issue No.139Development and biomarker-based validation of a novel feed formulation for managing production diseases in dairy buffaloes一种用于管理奶水牛生产疾病的新型过渡期饲料配方的开发及基于生物标志物的验证DOI: 10.3389/fvets.2026.1937866 Veterinary and animal science IF: 02.200Volume 34, Issue No.140Postnatal phenotypic stability and endocrine homeostasis in Holstein-Friesian heifers conceived via multiple ovulation and embryo transfer vs. artificial insemination经多次排卵胚胎移植与人工授精受孕的荷斯坦-弗里生母犊的出生后表型稳定性与内分泌稳态DOI: 10.1016/j.vas.2026.100863 Med J Armed Forces IndiaVolume 82, Issue 5No.141Sarcopenia and diabetes in older adults in the decade of healthy aging: A comprehensive review健康老龄化十年中老年人的肌肉减少症与糖尿病：一项综合性综述DOI: 10.1016/j.mjafi.2025.06.013 Med J Armed Forces IndiaVolume 82, Issue 5No.142Glycemic variability and insulin resistance: A risk marker in adult males predisposed to diabetes mellitus血糖变异性与胰岛素抵抗：糖尿病易感成年男性中的风险标志物DOI: 10.1016/j.mjafi.2025.10.015 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.143Melatonin receptor 1 signaling modulates the metabolic response to high-fat diet in female melatonin-proficient mice褪黑素受体1信号调控褪黑素充足雌性小鼠对高脂饮食的代谢反应DOI: 10.3389/fendo.2026.1884802 Advanced biomedical research IF: 01.000Volume 15, Issue No.144The Pivotal Role of miR-770 in Solid Tumors CarcinogenesismiR-770在实体瘤癌变中的关键作用DOI: 10.4103/abr.abr_307_23 Arch Bone Jt Surg IF: 01.800Volume 14, Issue 9No.145Postoperative Outcomes of Total Knee Arthroplasty in Patients with Alcohol Use Disorders: A Retrospective Propensity-Matched Analysis酒精使用障碍患者全膝关节置换术的术后结局：一项回顾性倾向匹配分析DOI: 10.22038/ABJS.2026.90939.4121 Endocrine-related cancer IF: 04.600Ahead of Print.No.146Parathyroid Carcinoma and Primary Hyperparathyroidism: Trends and Outcomes甲状旁腺癌与原发性甲状旁腺功能亢进症：趋势与结局DOI: 10.1530/ERC-26-0259 Curēus IF: 01.300Volume 18, Issue 8No.147Short-Chain Fatty Acids in Blood Pressure Management: A Systematic Review of Clinical Effects, Delivery Strategies, and Translational Barriers短链脂肪酸在血压管理中的应用：临床效应、递送策略与转化障碍的系统综述DOI: 10.7759/cureus.115011 J Exp Orthop IF: 02.700Volume 13, Issue 3No.148Perioperative outcomes of total and unicompartmental knee arthroplasty in patients with Type 2 diabetes mellitus: A propensity score-matched analysis2型糖尿病患者全膝关节置换术与单髁膝关节置换术的围手术期结局：倾向性评分匹配分析DOI: 10.1002/jeo2.70917 JoVE IF: 01.000Volume 0, Issue 235No.149Hepatocellular Carcinoma in Metabolic Dysfunction-Associated Steatotic Liver Disease Beyond Fibrosis: Metabolic, Microbial, and Immune Determinants​超越纤维化：代谢功能障碍相关脂肪性肝病中肝细胞癌的代谢、微生物与免疫决定因素DOI: 10.3791/73743 Endocr Metab Immune Disord Drug Targets IF: 02.000Volume 26, Issue No.150Immune Checkpoint Inhibitor-induced Diabetes Mellitus: A Clinical Case Series免疫检查点抑制剂诱导的糖尿病：临床病例系列DOI: 10.2174/0118715303482804260804060220 JCEM case reportsVolume 4, Issue 10No.151Pregnancy-unmasked latent autoimmune arginine vasopressin deficiency with anti-rabphilin-3a antibody positivity妊娠揭露出抗rabphilin-3A抗体阳性的潜伏性自身免疫性精氨酸加压素缺乏症DOI: 10.1210/jcemcr/luag291 Frontiers in nephrologyVolume 6, Issue No.152Real-world use of pegylated erythropoietin in CKD-related anemia: an Indian modified Delphi consensus聚乙二醇化促红细胞生成素在慢性肾脏病相关贫血中的真实世界应用：印度改良德尔菲共识DOI: 10.3389/fneph.2026.1864394 Diabetology international IF: 01.200Volume 17, Issue 4No.153All-cause mortality and lower extremity outcomes across diabetic kidney disease phenotypes in patients with diabetic foot ulcers: a long-term observational cohort study (SPECTRUM-DKD study)糖尿病足溃疡患者不同糖尿病肾脏病表型的全因死亡率和下肢结局：一项长期观察性队列研究（SPECTRUM-DKD研究）DOI: 10.1007/s13340-026-00932-3 Biochem Biophys Rep IF: 02.200Volume 48, Issue No.154Distinct metabolomic signatures of SGLT2 inhibitor vs. sulfonylurea in a paired human liver biopsy studySGLT2抑制剂与磺脲类药物在配对人类肝脏活检研究中的不同代谢组学特征DOI: 10.1016/j.bbrep.2026.102784 JoVE IF: 01.000Volume 0, Issue 235No.155Effect of Two Different Surgical Methods on Age-Related Cataracts with Long-Standing Type 2 Diabetes Mellitus: A Retrospective Case-Control Study两种不同手术方法对长期2型糖尿病合并年龄相关性白内障的影响：一项回顾性病例对照研究DOI: 10.3791/70546 Advanced biomedical research IF: 01.000Volume 15, Issue No.156A Comprehensive Meta-Analysis: Unveiling the Link between Apolipoprotein E and Diabetic Retinopathy一项综合荟萃分析：揭示载脂蛋白E与糖尿病视网膜病变之间的联系DOI: 10.4103/abr.abr_155_24 Bioscience reports IF: 04.700Ahead of Print.No.157Metataxonomic strategy to decipher gut bacteriome biomarkers of type 2 diabetes and obesity in Tunisian population基于元分类学策略解析突尼斯人群2型糖尿病和肥胖的肠道细菌组生物标志物DOI: 10.1042/BSR20260157 Journal of pediatric orthopedics IF: 01.500Ahead of Print.No.158Comments on "Is Susceptibility to Slipped Capital Femoral Epiphysis Linked to Obesity-associated Proximal Femoral Morphology?"对“股骨头骨骺滑脱的易感性是否与肥胖相关的股骨近端形态有关？”的评论DOI: 10.1097/BPO.0000000000003485 Maternal and child nutrition IF: 02.600Volume 22, Issue 3No.159Associations Between Duration of Lactation and Maternal Risk of Obesity-Related Cancers-A Historical Birth Cohort Study哺乳持续时间与母亲肥胖相关癌症风险之间的关联——一项历史性出生队列研究DOI: 10.1111/mcn.70240 BioMed research international IF: 02.300Volume 2026, Issue 1No.160Food Away From Home and Body Mass Index: Insights From a Quantile Regression Analysis of NHANES 2011-2020外出就餐与体重指数：基于NHANES 2011-2020分位数回归分析的见解DOI: 10.1155/bmri/6298673 Nutrición hospitalaria IF: 01.100Ahead of Print.No.161[Emotional factors and eating styles as predictors of binge eating disorder symptoms in women with overweight or obesity, considering age and nutritional status]情绪因素和饮食风格作为超重或肥胖女性暴食症症状的预测因素：考虑年龄和营养状况DOI: 10.20960/nh.06186 Respiratory care IF: 02.100Ahead of Print.No.162The Response of Dorsal Lung Compliance to Prone Positioning Differs by Body Mass Index in ARDS俯卧位对背侧肺顺应性的影响因体重指数而异DOI: 10.1177/19433654261487238 Obesity reviews IF: 07.400Ahead of Print.No.163Eighty Years After Vague: Advances in Understanding Ectopic Fat and Metabolic DysfunctionVague之后八十年：对异位脂肪与代谢功能障碍认识的进展DOI: 10.1111/obr.70229 Nutritional neuroscience IF: 03.600Ahead of Print.No.164Ketogenic diet reverses obesity-associated hippocampal dysfunction and cognitive impairment in rats: a dietary comparison study生酮饮食逆转大鼠肥胖相关海马功能障碍和认知损害：一项饮食比较研究DOI: 10.1080/1028415X.2026.2734187 Am J Physiol Heart Circ Physiol IF: 04.100Ahead of Print.No.165Sympathetic vascular transduction in adults with hypertension and obesity-associated hypertension高血压与肥胖相关高血压成年人的交感血管转导DOI: 10.1152/ajpheart.00298.2026 Rom J Intern MedAhead of Print.No.166Real-World Effectiveness of Biologic Therapy in Patients with Psoriasis: Metabolic Comorbidities and Treatment Outcomes生物制剂治疗银屑病患者的真实世界有效性：代谢合并症与治疗结局DOI: 10.2478/rjim-2026-0020 Circulation Research IF: 16.200Ahead of Print.No.167Multilaboratory, Blinded, Randomized Trial of Five Cerebroprotectants in Ischemic Stroke五种脑保护剂治疗缺血性卒中的多实验室、盲法、随机试验DOI: 10.1161/CIRCRESAHA.126.329467 Annals of surgery openVolume 7, Issue 3No.168Long-Term Healthcare-Related Costs Eight Years After Laparoscopic Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: A Nationwide Register-Based Study腹腔镜Roux-en-Y胃旁路术与袖状胃切除术后八年长期医疗相关成本：一项全国性注册研究DOI: 10.1097/AS9.0000000000000711 EXCLI journal IF: 04.900Volume 25, Issue No.169A diethylene glycol oligomer squalene derivative modulates metabolic gene expression in ob/ob mice二甘醇寡聚角鲨烯衍生物调节ob/ob小鼠的代谢基因表达DOI: 10.17179/excli2026-9373 PNAS nexus IF: 03.800Volume 5, Issue 9No.170Why the mortality penalty of smoking is rising over time为何吸烟的死亡惩罚随时间上升DOI: 10.1093/pnasnexus/pgag280 Obesity pillarsVolume 20, Issue No.171Exploring the impact of adult obesity in Spain: Insights from a systematic literature review探索西班牙成人肥胖的影响：一项系统性文献综述的启示DOI: 10.1016/j.obpill.2026.100334 Int J Womens Health IF: 02.600Volume 18, Issue No.172Intergenerational Effects of Maternal Stressful Life Events Before Pregnancy on Offspring Growth: A Lifecourse Approach from a Prospective Cohort母亲孕前压力性生活事件对子代生长的代际影响：基于前瞻性队列的生命历程研究DOI: 10.2147/IJWH.S609252 Case reports in geneticsVolume 2026, Issue No.173GRIA3 Duplication at Xq25 in a Young Adult Male With Profound Intellectual Disability and Morbid Obesity: A Case Report一例重度智力障碍与病态肥胖年轻成年男性Xq25区GRIA3重复的病例报告DOI: 10.1155/crig/7670059 Frontiers in public health IF: 03.400Volume 14, Issue No.174Public health interventions for the prevention and management of overweight and obesity in children and adolescents: a rapid review儿童和青少年超重和肥胖预防与管理的公共卫生干预措施：快速综述DOI: 10.3389/fpubh.2026.1893709 Med J Armed Forces IndiaVolume 82, Issue 5No.175Confronting the obesity and metabolic wave in India: Phenotypes, pharmacotherapy, and public health应对印度肥胖与代谢浪潮：表型、药物治疗与公共卫生DOI: 10.1016/j.mjafi.2026.08.002 Obesity science & practice IF: 01.900Volume 12, Issue 5No.176Improving Medication Classification in GLP-1RA Research: Feasibility of a Photo-Review Protocol改善GLP-1RA研究中的药物分类：照片审核方案的可行性DOI: 10.1002/osp4.70200 Med J Armed Forces IndiaVolume 82, Issue 5No.177A systematic review and meta-analysis of non-alcoholic fatty liver disease (NAFLD) versus non-NAFLD among diabetes mellitus patients糖尿病患者中非酒精性脂肪性肝病与非非酒精性脂肪性肝病的系统评价和荟萃分析DOI: 10.1016/j.mjafi.2026.01.024 Journal of Arrhythmia IF: 01.700Volume 42, Issue 5No.178Glucagon-Like Peptide-1 Agonists and the Incidence of Atrial Fibrillation in Obese Patients With Heart Failure With Preserved Ejection Fraction and No Diabetes胰高血糖素样肽-1受体激动剂与肥胖非糖尿病射血分数保留的心力衰竭患者心房颤动发生率DOI: 10.1002/joa3.70455 Mol Genet Metab Rep IF: 01.900Volume 49, Issue No.179A comprehensive overview of genetic mutations in Iranian patients with Bardet-Biedl syndrome伊朗Bardet-Biedl综合征患者基因突变的全面概述DOI: 10.1016/j.ymgmr.2026.101357 Diabetology international IF: 01.200Volume 17, Issue 4No.180Low serum free testosterone is independently associated with sarcopenic obesity in males with type 2 diabetes: a post hoc cross-sectional analysis from the impact of diabetes mellitus on dynapenia study低血清游离睾酮与男性2型糖尿病患者的肌少症性肥胖独立相关：来自糖尿病对肌力减退影响研究的事后横断面分析DOI: 10.1007/s13340-026-00929-y Frontiers in pharmacology IF: 04.800Volume 17, Issue No.181Therapeutic effect of ginseng: a non-antibiotic approach to preventing pathogenic bacterial infections and restoring gut microbiota composition人参的治疗作用：预防致病性细菌感染与恢复肠道微生物群组成的非抗生素途径DOI: 10.3389/fphar.2026.1866260 J CHILD FAM STUD IF: 01.800Volume 35, Issue 9No.182Parenting Stress, Parental Self-Efficacy, and Coparenting: Prospective Associations with Child Metabolic Health育儿压力、父母自我效能感与共同养育：与儿童代谢健康的前瞻性关联DOI: 10.1007/s10826-026-03356-4 Frontiers in immunology IF: 05.900Volume 17, Issue No.183Obesity and COVID-19 severity independently shape adipokine dysregulation and immune cell remodeling肥胖与COVID-19严重程度独立塑造脂肪因子失调与免疫细胞重塑DOI: 10.3389/fimmu.2026.1890251 Frontiers in medicine IF: 03.000Volume 13, Issue No.184Clinical sub-phenotypes of co-occurring metabolic syndrome and pre-frailty and their associated factors in older adults: findings from Whitehall II study老年人代谢综合征与衰弱前期共病的临床亚表型及其相关因素：Whitehall II研究结果DOI: 10.3389/fmed.2026.1909752 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.185Long-term metabolic risks after thyroidectomy and thyroid hormone therapy in thyroid cancer survivors: a nationwide cohort study甲状腺癌幸存者甲状腺切除术后及甲状腺激素治疗后的长期代谢风险：一项全国性队列研究DOI: 10.3389/fendo.2026.1845515 Experimental physiology IF: 02.800Ahead of Print.No.186Women with a history of gestational diabetes mellitus have preserved sensory nerve-mediated dilatation in the cutaneous microvasculature有妊娠期糖尿病病史的女性皮肤微血管中感觉神经介导的舒张功能得以保留DOI: 10.1113/EP093827 Clin Pharmacol Ther IF: 05.500Ahead of Print.No.187Trust, but Verify: Translating Dosing Evidence to Understudied Populations in Low- and Middle-Income Countries信任但验证：将剂量证据转化至中低收入国家中研究不足的人群DOI: 10.1002/cpt.70494 Curēus IF: 01.300Volume 18, Issue 8No.188Real-World Prescribing Patterns and Clinical Characteristics of Patients With Type 2 Diabetes Mellitus Receiving Empagliflozin-Sitagliptin-Metformin Fixed-Dose Combination Therapy接受恩格列净-西格列汀-二甲双胍固定剂量复方制剂治疗的2型糖尿病患者的真实世界处方模式与临床特征DOI: 10.7759/cureus.115001 Curēus IF: 01.300Volume 18, Issue 8No.189Beyond Glycated Hemoglobin (HbA1c): A Systematic Review of Metabolic Interventions, Insulin Resistance, and Cognitive Function Across the Obesity-to-Diabetes Continuum超越糖化血红蛋白（HbA1c）：从肥胖到糖尿病连续谱中代谢干预、胰岛素抵抗与认知功能的系统综述DOI: 10.7759/cureus.115012 Kidney international reports IF: 05.700Volume 11, Issue 11No.190Lack of Short-Term Antiproteinuric Response to Dapagliflozin in a Patient With Dent Disease Type 2达格列净在Dent病2型患者中缺乏短期抗蛋白尿反应DOI: 10.1016/j.ekir.2026.107039 FCVM IF: 02.900Volume 13, Issue No.191Observational study on initiation of dapagliflozin in heart failure with reduced ejection fraction in the United Kingdom英国射血分数降低的心力衰竭患者启动达格列净治疗的观察性研究DOI: 10.3389/fcvm.2026.1858743 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.192SGLT2 inhibitors and outcomes in the chronic Post-LVAD phase: a multicenter real-world cohort studySGLT2抑制剂在左心室辅助装置植入后慢性期的结局：一项多中心真实世界队列研究DOI: 10.3389/fphar.2026.1922067 CRSLSVolume 13, Issue 3No.193Robotic Splenectomy for Refractory Immune Thrombocytopenic Purpura机器人脾切除术治疗难治性免疫性血小板减少性紫癜DOI: 10.4293/CRSLS.2026.00075 Arch Endocrinol Metab IF: 02.300Volume 70, Issue 5No.194Beyond insulin-like growth factor-1 (IGF-1) normalization: portal insulin and hepatic growth hormone (GH) sensitivity across metabolic disease超越胰岛素样生长因子-1（IGF-1）正常化：门静脉胰岛素与代谢性疾病中的肝脏生长激素（GH）敏感性DOI: 10.20945/2359-4292-2026-0115 Cell journal IF: 01.700Volume 28, Issue 1No.195Genetic and Epigenetic Basis of Polycystic Ovary Syndrome:A Systematic Review多囊卵巢综合征的遗传与表观遗传基础：一项系统综述DOI: 10.22074/cellj.2026.2057389.1826 Journal of medicinal food IF: 02.000Ahead of Print.No.196Eggshell Membrane (Ovoderm®-AS) Promotes Hair Growth via Upregulation of Growth Factors and Wnt/β-Catenin-Related Gene Expression in Mice蛋壳膜（Ovoderm®-AS）通过上调小鼠生长因子及Wnt/β-Catenin相关基因表达促进毛发生长DOI: 10.1177/1096620X261490880 Am J Physiol Regul Integr Comp Physiol IF: 02.300Ahead of Print.No.197Nutrient restriction dynamically alters glucose tolerance and ceramide concentrations in periparturient ewes营养限制动态改变围产期母羊的葡萄糖耐量和神经酰胺浓度DOI: 10.1152/ajpregu.00098.2026 Frontiers in medicine IF: 03.000Volume 13, Issue No.198Ophthalmic manifestations of celiac disease in Tabuk City, Saudi Arabia沙特阿拉伯塔布克市乳糜泻的眼部表现DOI: 10.3389/fmed.2026.1801404 Endocrinology IF: 03.300Ahead of Print.No.199Priming Metabolic Failure in an Obesogenic World: Programming of Food Preferences by Environmental Endocrine Disruptors在致肥胖环境中启动代谢衰竭：环境内分泌干扰物对食物偏好的编程DOI: 10.1210/endocr/bqag109 Korean Circulation Journal IF: 03.100Ahead of Print.No.200Long-Term Impact of New-Onset Diabetes Mellitus in Hypertensive Patients高血压患者新发糖尿病的长期影响DOI: 10.4070/kcj.2026.0017 Spine IF: 03.500Ahead of Print.No.201Perioperative Aspirin Continuation Is Not Associated With Increased Surgical Morbidity Following Minimally Invasive Anterior-to-Psoas Lumbar Fusion: A Propensity-Matched Analysis围手术期继续使用阿司匹林与微创前路腰大肌腰椎融合术后手术并发症增加无关：一项倾向性匹配分析DOI: 10.1097/BRS.0000000000005878 British journal of dermatology IF: 09.600Ahead of Print.No.202Reply to 'Cautious Interpretation of the Association Between Topical Corticosteroid Exposure and Type 2 Diabetes'对《谨慎解读外用皮质类固醇暴露与2型糖尿病之间的关联》的回复DOI: 10.1093/bjd/ljag420 Nature biomedical engineering IF: 26.600Ahead of Print.No.203Biomimetic graphitic carbon nitride nanoparticles for multiscale photomodulation and therapeutic intervention仿生石墨相氮化碳纳米颗粒用于多尺度光调控与治疗干预DOI: 10.1038/s41551-026-01773-w Journal of diabetes research IF: 03.400Volume 2026, Issue 1No.204Automated Insulin Delivery in Pregnancy With Type 1 Diabetes: An Integrative Review of Clinical Evidence, Socio-Technical Implementation and Equity1型糖尿病妊娠期自动胰岛素输送：临床证据、社会技术实施与公平性的整合综述DOI: 10.1155/jdr/1989683 J Cachexia Sarcopenia Muscle IF: 09.100Volume 17, Issue 5No.205Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles胰腺癌破坏心肺肌肉中基因表达的昼夜节律模式DOI: 10.1002/jcsm.70383 Ophthalmic genetics IF: 01.000Ahead of Print.No.206Could thiamine supplementation delay the progression of retinal dystrophy in Rogers syndrome?补充硫胺素能否延缓Rogers综合征中视网膜营养不良的进展？DOI: 10.1080/13816810.2026.2736738 Eur J Endocrinol IF: 05.200Ahead of Print.No.207Pituitary adenomas in older patients - approaches, challenges and future directions老年患者垂体腺瘤——方法、挑战与未来方向DOI: 10.1093/ejendo/lvag183 Journal of diabetes research IF: 03.400Volume 2026, Issue 1No.208A Narrative Review of Local Therapies in Diabetic Foot Ulcers: Promises, Limitations and Unmet Needs糖尿病足溃疡局部治疗的叙述性综述：前景、局限性与未满足需求DOI: 10.1155/jdr/9428774 Spine IF: 03.500Ahead of Print.No.209Response to Letter to the Editor regarding "Long-Term Mechanical Complications After Lumbar Fusion in Patients Receiving Tirzepatide vs Other GLP-1 Receptor Agonists"关于“接受替尔泊肽与其他GLP-1受体激动剂治疗的腰椎融合患者远期机械并发症”致编辑信的回复DOI: 10.1097/BRS.0000000000005876 British journal of pharmacology IF: 07.700Ahead of Print.No.210RETRACTION: Implications and Hidden Toxicity of Cardiometabolic Syndrome and Early-Stage Heart Failure in Carfilzomib-Induced Cardiotoxicity撤稿：心血管代谢综合征与早期心力衰竭在卡非佐米诱导的心脏毒性中的影响及隐藏毒性DOI: 10.1111/bph.70699 Yonsei Medical Journal IF: 02.800Volume 67, Issue 10No.211Association between Early-Onset Metabolic Diseases and Adverse Mental Health Conditions: A Nationwide Cross-Sectional Study早发性代谢性疾病与不良心理健康状况之间的关联：一项全国性横断面研究DOI: 10.3349/ymj.2025.0342 CCI IF: 01.900Ahead of Print.No.212Early Versus Delayed Percutaneous Coronary Intervention in Patients With NSTEMI and Stable Heart Failure非ST段抬高型心肌梗死合并稳定型心力衰竭患者早期与延迟经皮冠状动脉介入治疗的比较DOI: 10.1002/ccd.70861 J Antimicrob Chemother IF: 03.600Volume 81, Issue 10No.213Evaluation of teicoplanin concentrations for loading-dose optimization across BMI categories基于BMI分层的替考拉宁浓度评估以优化负荷剂量DOI: 10.1093/jac/dkag329 Medical science monitor IF: 02.100Volume 32, Issue No.214Lifestyle Behaviors, Physical Activity, and Body Composition in Women With Gestational Diabetes: A Real-World Observational Study From Poland妊娠期糖尿病女性的生活方式行为、体力活动与身体成分：一项来自波兰的真实世界观察性研究DOI: 10.12659/MSM.953627 Pediatric obesity IF: 02.700Volume 21, Issue 9No.215Affective States and Ultra-Processed Food Intake in Youth With Overweight or Obesity: Evidence From Laboratory and Ecological Momentary Assessment Studies超重或肥胖青少年的情感状态与超加工食品摄入：来自实验室和生态瞬时评估研究的证据DOI: 10.1111/ijpo.70150 Korean J Fam Med IF: 02.600Volume 47, Issue 5No.216Nonarteritic anterior ischemic optic neuropathy after rapid weight loss during semaglutide therapy: a case report司美格鲁肽治疗期间快速减重后发生非动脉炎性前部缺血性视神经病变：一例病例报告DOI: 10.4082/kjfm.26.0135 BMC psychology IF: 03.000Volume 14, Issue 1No.217Approaches to obesity among adults with accurate body-size perception: a qualitative thematic analysis体型感知准确的成年人对肥胖的应对方式：一项定性主题分析DOI: 10.1186/s40359-026-05426-0 Sleep & breathing IF: 02.000Volume 30, Issue 5No.218The impact of obstructive sleep apnea on skin wound healing - from preclinical perspective to clinical evidence: A narrative review阻塞性睡眠呼吸暂停对皮肤伤口愈合的影响——从临床前视角到临床证据：一项叙述性综述DOI: 10.1007/s11325-026-03804-x International journal of obesity IF: 03.800Ahead of Print.No.219Clinical obesity phenotypes among older adults: prevalence, determinants, and morbidity burden from the Longitudinal Ageing Study in India印度老年人临床肥胖表型：来自印度纵向老龄化研究的患病率、决定因素与疾病负担DOI: 10.1038/s41366-026-02226-9 International journal of obesity IF: 03.800Ahead of Print.No.220Adiposity trajectory as a predictor of chronic and multisite pain in the transition from childhood to adolescence: A prospective study of a large birth cohort脂肪量轨迹作为儿童期向青春期过渡期间慢性和多部位疼痛的预测因素：一项大型出生队列的前瞻性研究DOI: 10.1038/s41366-026-02227-8 International journal of obesity IF: 03.800Ahead of Print.No.221Influence of Lactobacillus plantarum on anthropometric and inflammatory parameters in obesity: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials植物乳杆菌对肥胖症人体测量学与炎症参数的影响：一项基于GRADE评估的随机对照试验系统综述与荟萃分析DOI: 10.1038/s41366-026-02221-0 Journal of Human Hypertension IF: 03.400Ahead of Print.No.222Interaction between adiposity and genetic risk score on blood pressure traits in Mexican adults墨西哥成年人肥胖与遗传风险评分对血压特征的交互作用DOI: 10.1038/s41371-026-01222-w Eur J Clin Nutr IF: 03.300Ahead of Print.No.223Geographically clustered dietary patterns associated with body mass index among nationally represented adults in Malaysia: a substitution analysis马来西亚全国代表性成年人体重指数相关的地理聚集性饮食模式：一项替代分析DOI: 10.1038/s41430-026-01831-1 Anaesth Crit Care Pain Med IF: 04.700Ahead of Print.No.224Ramped positioning modifies the effect of cricoid and left paratracheal pressure on perceived glottic-view quality during videolaryngoscopy in adults with obesity: a secondary image-based analysis斜坡位改变环状软骨和左气管旁压力对肥胖成人视频喉镜下声门视野质量感知的影响：一项基于图像的二次分析DOI: 10.1016/j.accpm.2026.101921 176 Diabetes Mellitus(DM) 糖尿病 104 Obesity 肥胖症 62 Insulin 胰岛素 23 Type 2 diabetes mellitus(T2DM) 2型糖尿病 17 Metabolic Syndrome 代谢综合征 11 Semaglutide 司美格鲁肽 11 Diabetic Foot 糖尿病足 9 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 9 Diabetic Retinopathy 糖尿病视网膜病 8 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 7 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 6 Hypoglycemic Agents 降糖药 6 Metformin 二甲双胍 5 Tirzepatide 替尔泊肽 5 Dapagliflozin 达格列净 4 Diabetic Peripheral Neuropathy(PDN) 糖尿病周围神经病变 3 Diabetic Neuropathies 糖尿病性神经病变 3 Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i) 钠-葡萄糖协同转运蛋白2抑制剂 2 Empagliflozin 恩格列净 2 Sitagliptin 西他列汀 2 Diabetes Complications 糖尿病并发症 1 Diabetic acidosis 糖尿病性酸中毒 1 Diabetic Angiopathies 糖尿病血管病变 1 Diabetic Cardiomyopathies 糖尿病心肌病 1 gamma-Aminobutyric Acid(GABA) γ-氨基丁酸 1 Gabapentin 加巴喷丁 1 mirogabalin 美洛加巴林 1 Tofogliflozin 托格列净 1 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 1 Type 1 diabetes mellitus(T1DM) 1型糖尿病 编辑：韩玉莲 审校：韩玉莲