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更新于：2025-05-16
Propylthiouracil
丙硫氧嘧啶
更新于：2025-05-16
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 加拿大 (1945-12-31), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C7H10N2OS |
InChIKeyKNAHARQHSZJURB-UHFFFAOYSA-N |
CAS号51-52-5 |
关联
15
项与 丙硫氧嘧啶 相关的临床试验CTR20244420
丙硫氧嘧啶片（规格：50mg）在中国健康受试者中空腹及餐后单次给药的一项单中心、随机、开放、两制剂、两序列、两周期交叉的生物等效性研究
CTRI/2024/04/065884
To Evaluate taste sensitivity to 6 N Propylthiouracil as a screening system to classify children of age 6 to 12 years for caries risk - A cross sectional study - NIL
NCT05762146
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Ischaemic STROKE (REPO-STROKE IIa)
100 项与 丙硫氧嘧啶 相关的临床结果
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100 项与 丙硫氧嘧啶 相关的转化医学
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100 项与 丙硫氧嘧啶 相关的专利（医药）
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6,630
项与 丙硫氧嘧啶 相关的文献（医药）2025-08-01FOOD CHEMISTRY
Amide carbon quantum dots as chemiluminescent probes for the real-time quantitative detection of the carcinogen ethylene thiourea and its homologs in vegetables
Article
作者: Wei, Lijun ; Zhang, Guowen ; Zhou, Bixiao ; Cai, Mengdie ; Cheng, Xianglei ; Wang, Xinyu
Ethylene thiourea (ETU) and propylene thiourea (PTU), the degradation products of dithiocarbamates, are carcinogenic, teratogenic, and mutagenic. In this study, we developed an ultrasensitive method for the simultaneous detection of ETU and PTU using amidated carbon quantum dots (A-CDs) as chemiluminescent probes. The distinctive chemiluminescence (CL) mechanisms of the A-CDs were elucidated using CL spectroscopy, radical trapping experiments, and mass spectrometry. ETU or PTU are oxidized by Ce(IV) resulting in the formation of sulfur-based free radicals. Then the radicals are selectively recognized by the A-CDs accompanying with CL emission. The high-performance liquid chromatography-CL method was validated by quantifying ETU and PTU in vegetables, wherein the detection limit was 0.17 μg·kg-1. Comparing with previous literatures, the proposed method demonstrated advantages with lower solvent use, shorter detection time, reduced matrix effects, higher accuracy and precision. The results indicated that ETU was really detected in tomatoes, implying the potential risk of public health.
2025-06-01NEUROSCIENCE
Perinatal thyroid hormone deficiency leads to oxidative stress-induced neuronal damage and activation of astrocytes in rat hippocampus: Neuroprotective effect of exercise
Article
作者: Zare, Zohreh ; Mohammadi, Moslem ; Zarbakhsh, Sam
Thyroid hormones play a crucial role in proper brain development. This study examined the effects of developmental thyroid hormone deficiency on neuronal survival, glial fibrillary acidic protein (GFAP)-positive cells, and oxidative stress biomarkers in the hippocampus of congenital hypothyroid rats. The effectiveness of treadmill exercise in attenuating oxidative stress-induced neuronal damage and astrocyte activation was also evaluated. Pregnant Wistar rats in the hypothyroid group received propylthiouracil in their drinking water from gestational day 6 until weaning, while control dams received only tap water. Then, male offspring from both groups were further divided into two sub-groups: with or without four weeks of treadmill exercise. After sacrifice, the right hemispheres were processed for cresyl violet staining and immunohistochemistry, while the left hippocampi were used for biochemical assays. Results showed a reduced number of neurons and an increased number of GFAP-positive cells in the CA1 region of hypothyroid rats, with no significant changes in the CA3 region. Additionally, congenital hypothyroidism was associated with increased malondialdehyde levels, decreased glutathione levels, and reduced superoxide dismutase and catalase activity in the hippocampus. Treadmill exercise reduced astrocyte activation and protected neurons by inhibiting oxidative stress. Collectively, our results indicate that congenital thyroid hormone deficiency triggers astrocyte activation and compromises neuronal survival in the CA1 region by inducing oxidative stress. Exercise may serve as a beneficial supplementary treatment for attenuating oxidative stress-induced neuronal damage in congenital hypothyroidism.
2025-06-01JOURNAL OF MOLECULAR STRUCTURE
Synthesis, antimicrobial activity, molecular docking and molecular dynamics studies of novel bioactive compounds derived from propylthiouracil
作者: Mady, Mohamed F. ; Sayed, Mostafa ; Tolba, Mahmoud S. ; Hassan, Mohammad H. A. ; Hamed, Mahmoud M. ; El-Rashedy, Ahmed A. ; El-Dean, Adel M. Kamal ; Ahmed, Mostafa
Propylthiouracil (PTU) and its derivatives exhibit a wide range of biol. activities, making them valuable compounds in pharmacol. and medicinal chem.In the present work some new heterocyclic compounds (2-9) were synthesized through multi steps using propylthiouracil (PTU) 1 as starting material.The claimed chem. structures of all new synthesized compounds were elucidated by spectral anal. including FTIR, NMR and Mass spectroscopy.Furthermore, the antimicrobial activity for all synthesized compounds were investigated against different strains of bacteria and fungi.The results suggested that compounds 3, 5, 6a, 6b, 6c, 7b demonstrate pos. results against the Fluconazole" as the antifungal pos. control, while compounds 5, 6a 6c, 8 show pos. results against Cefotaxime" as the antibacterial pos. control.Moreover, mol. dynamic simulations revealed that compound 5 demonstrated significant interactions with essential residues of the binding site, resulting in a stable complex throughout the entire simulation run.
100 项与 丙硫氧嘧啶 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 格雷夫斯病 | 美国 | 1947-07-28 | |
| 毒性多结节性甲状腺肿 | 美国 | 1947-07-28 | |
| 甲状腺功能亢进症 | 加拿大 | 1945-12-31 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | - | Propylthiouracil (PTU) | 廠壓壓製鑰積鑰蓋淵鹹(遞鑰憲鬱夢襯餘艱蓋鹹) = 襯選範築壓觸鬱願齋積 鹽鏇遞積築鏇鬱鏇齋製 (觸遞鏇遞膚鬱鑰觸鏇構 ) | - | 2024-01-01 | ||
Methimazole (MMI) | 廠壓壓製鑰積鑰蓋淵鹹(遞鑰憲鬱夢襯餘艱蓋鹹) = 憲醖壓範積衊範觸獵願 鹽鏇遞積築鏇鬱鏇齋製 (觸遞鏇遞膚鬱鑰觸鏇構 ) | ||||||
N/A | - | Methimazole 40 mg every 12 hours | 顧繭構築淵顧襯糧壓蓋(壓窪憲衊網壓鏇製遞積) = 顧憲壓衊積夢鑰鬱願製 鑰壓壓鏇選窪壓夢鑰願 (顧糧醖憲糧襯膚膚鹹鬱 ) 更多 | - | 2023-10-05 | ||
PTU 200 mg every 4 hours | 醖簾獵範蓋淵廠築網構(積壓壓網襯鑰餘鑰鏇鏇) = 遞觸夢艱衊鏇鏇襯鑰廠 壓糧鹹襯鑰餘積製廠獵 (鑰憲遞襯選醖鹹網窪鏇 ) 更多 | ||||||
N/A | - | 網鬱顧鹹範範醖襯範鬱(膚窪壓齋醖鏇鑰鬱衊築) = 餘觸窪鬱廠壓觸鑰遞鹹 醖醖範鬱築製餘窪願餘 (積積遞齋鑰夢鑰艱夢範 ) 更多 | - | 2021-05-03 | |||
N/A | 格雷夫斯病 一线 | 398 | Antithyroid Drugs (Guideline concordant care) | 廠築繭築鏇製齋鬱顧廠(淵壓蓋衊餘觸製願襯遞) = 窪廠築襯築構襯醖夢膚 顧壓襯遞構窪簾蓋鹽衊 (顧艱淵齋醖夢鬱製觸網 ) 更多 | - | 2021-05-03 | |
Antithyroid Drugs (Non-guideline concordant care) | 廠築繭築鏇製齋鬱顧廠(淵壓蓋衊餘觸製願襯遞) = 窪鹹鏇簾鏇顧選網艱積 顧壓襯遞構窪簾蓋鹽衊 (顧艱淵齋醖夢鬱製觸網 ) 更多 | ||||||
N/A | - | 173 | Control (no PTU) | 襯壓蓋範衊繭觸願鹽顧(鬱網憲鬱鹽鑰鏇糧醖獵) = 範憲觸齋顧獵淵窪選憲 鏇襯齋夢獵餘獵襯願顧 (憲築艱製鹽醖夢醖鏇製 ) 更多 | 不佳 | 2018-05-23 | |
PTU pretreatment | 襯壓蓋範衊繭觸願鹽顧(鬱網憲鬱鹽鑰鏇糧醖獵) = 廠構餘鏇遞顧築鑰齋淵 鏇襯齋夢獵餘獵襯願顧 (憲築艱製鹽醖夢醖鏇製 ) 更多 | ||||||
N/A | 抗中性粒细胞胞质抗体相关性血管炎 MPO-ANCA | - | Propylthiouracil (PTU) | 鹹鑰艱糧衊製餘鹽製糧(憲廠範願構襯積糧憲繭) = 網鑰艱鏇壓鹽醖範餘製 鹽齋積積衊夢繭鏇積範 (襯餘衊觸齋願齋願糧憲 ) | 积极 | 2016-11-15 | |
Pulse dose steroids, plasma exchange, and immunotherapy | 鹹鑰艱糧衊製餘鹽製糧(憲廠範願構襯積糧憲繭) = 觸廠築憲願製憲糧襯遞 鹽齋積積衊夢繭鏇積範 (襯餘衊觸齋願齋願糧憲 ) |
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