预约演示
更新于：2025-08-06
Propylthiouracil
丙硫氧嘧啶
更新于：2025-08-06
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 加拿大 (1945-12-31), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C7H10N2OS |
InChIKeyKNAHARQHSZJURB-UHFFFAOYSA-N |
CAS号51-52-5 |
关联
15
项与 丙硫氧嘧啶 相关的临床试验CTR20244420
丙硫氧嘧啶片（规格：50mg）在中国健康受试者中空腹及餐后单次给药的一项单中心、随机、开放、两制剂、两序列、两周期交叉的生物等效性研究
CTRI/2024/04/065884
To Evaluate taste sensitivity to 6 N Propylthiouracil as a screening system to classify children of age 6 to 12 years for caries risk - A cross sectional study - NIL
NCT05762146
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Ischaemic STROKE (REPO-STROKE IIa)
100 项与 丙硫氧嘧啶 相关的临床结果
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100 项与 丙硫氧嘧啶 相关的转化医学
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100 项与 丙硫氧嘧啶 相关的专利（医药）
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6,653
项与 丙硫氧嘧啶 相关的文献（医药）2025-08-01AQUATIC TOXICOLOGY
Artificial intelligence (AI)-driven morphological assessment of zebrafish larvae for developmental toxicity chemical screening
Article
作者: Shah, Ruchir ; Hsieh, Jui-Hua ; Ryan, Kristen ; Merrick, Alex ; Tandon, Arpit ; Green, Adrian J ; Elmore, Rebecca ; Howard, Brian E ; Shockley, Keith
Screening chemicals using the zebrafish embryo developmental toxicity assay requires visual assessment of larval morphological changes based on images by experienced screeners. The process is time-consuming and prone to subjectivity. However, deep learning models trained using labeled image data offer a more objective and efficient alternative. As part of the Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) project, which aims to provide a scientific basis for programmatic decisions on the routine use of zebrafish in toxicological evaluations, we developed deep-learning classification and segmentation models to support image-based assessments. Using labeled SEAZIT image data from embryos exposed to various chemicals for 5 days, we trained classification models to detect 20 distinct types of larval morphological changes. We also developed segmentation models to identify and measure larval regions of interest. In a baseline binary classification task distinguishing normal embryos from those with any morphological change, our multi-view convolutional neural network (MVCNN) achieved an F1 score of 0.88, demonstrating strong overall performance. Among classifiers for specific morphological changes, eight achieved F1 scores above 0.70. Grouping related abnormalities further improved performance, with five out of seven grouped classifiers reaching F1 scores near 0.80. Segmentation models for most of the regions of interest (9 out of 11) have an Intersection over Union (IoU) score of at least 0.80. Together, these models facilitate rapid, standardized and reliable evaluation of larval morphological changes in zebrafish images, reducing the need for subjective manual review and enhancing reproducibility in development toxicity screening.
2025-08-01Endocrine Metabolic & Immune Disorders-Drug Targets
Cardiovascular Findings and Effects of Caffeine on Experimental Hypothyroidism
Article
作者: Ozmen, Ozlem ; Yuksel, Duygu
Background::
Thyroid hormone deficiencies can disrupt organ functions, significantly
impacting the cardiovascular system. Recently, the effects of thyroid hormones on the heart
have garnered increased attention. However, most studies are conducted on humans using clinical
data, while cellular-level and experimental studies remain limited.
Objective::
This study aimed to investigate the cardiovascular implications of hypothyroidism
and evaluate the impact of caffeine on cardiac health in rats induced with hypothyroidism using
propylthiouracil (PTU).
Methods::
The study involved 60 rats divided into six groups. Group 1 served as the untreated
control. Group 2 received PTU for two months to induce hypothyroidism. Group 3 received
PTU for one month, followed by caffeine for one month. Group 4 received caffeine for two
months. Group 5 received both PTU and caffeine simultaneously for two months. Group 6 received
PTU for one month, followed by one month under normal conditions.
Results::
During necropsy, normal thyroid glands were observed in Groups 1, 4, and 6, enlarged
thyroids in Group 2, and smaller thyroids in Groups 3 and 5. Microscopic examination revealed
varying thyroid histologies: Group 2 showed significant epithelial cell proliferation and absent
colloid, while Groups 3, 5, and 6 had altered yet colloid-containing acini. Macroscopic inspection
of hearts appeared normal across all groups. However, histopathological examination revealed
significant hyperemia and microhemorrhages in Group 2, contrasting with normal findings
in other groups. Immunohistochemical analysis indicated reduced cardiac troponin expression
in Group 2, while other groups maintained prominent expression. Additionally, Group 2
displayed increased serum TSH levels and decreased T3 and T4 levels.
Conclusions::
The findings suggest that administering caffeine alongside or after PTU treatment
in rats with experimentally induced hypothyroidism may ameliorate thyroid and cardiac irregularities.
This study indicates caffeine's potential in mitigating the adverse effects of hypothyroidism
on thyroid and heart health.
2025-08-01FOOD CHEMISTRY
Amide carbon quantum dots as chemiluminescent probes for the real-time quantitative detection of the carcinogen ethylene thiourea and its homologs in vegetables
Article
作者: Wei, Lijun ; Zhang, Guowen ; Zhou, Bixiao ; Cai, Mengdie ; Cheng, Xianglei ; Wang, Xinyu
Ethylene thiourea (ETU) and propylene thiourea (PTU), the degradation products of dithiocarbamates, are carcinogenic, teratogenic, and mutagenic. In this study, we developed an ultrasensitive method for the simultaneous detection of ETU and PTU using amidated carbon quantum dots (A-CDs) as chemiluminescent probes. The distinctive chemiluminescence (CL) mechanisms of the A-CDs were elucidated using CL spectroscopy, radical trapping experiments, and mass spectrometry. ETU or PTU are oxidized by Ce(IV) resulting in the formation of sulfur-based free radicals. Then the radicals are selectively recognized by the A-CDs accompanying with CL emission. The high-performance liquid chromatography-CL method was validated by quantifying ETU and PTU in vegetables, wherein the detection limit was 0.17 μg·kg-1. Comparing with previous literatures, the proposed method demonstrated advantages with lower solvent use, shorter detection time, reduced matrix effects, higher accuracy and precision. The results indicated that ETU was really detected in tomatoes, implying the potential risk of public health.
100 项与 丙硫氧嘧啶 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 格雷夫斯病 | 美国 | 1947-07-28 | |
| 毒性多结节性甲状腺肿 | 美国 | 1947-07-28 | |
| 甲状腺功能亢进症 | 加拿大 | 1945-12-31 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | - | Propylthiouracil (PTU) | 鬱齋膚網鑰壓鹽鏇壓範(鹽鬱範構襯衊鏇鏇憲顧) = 繭鹽膚淵鹹築鹽網淵壓 襯選範簾淵膚顧鹽簾積 (願鏇鬱夢廠願膚夢範壓 ) | - | 2024-01-01 | ||
Methimazole (MMI) | 鬱齋膚網鑰壓鹽鏇壓範(鹽鬱範構襯衊鏇鏇憲顧) = 願糧窪糧壓艱選廠憲夢 襯選範簾淵膚顧鹽簾積 (願鏇鬱夢廠願膚夢範壓 ) |
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