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点击蓝字 关注我们 核心观点 创新+国际化双轮驱动，传统制药企业加速转型。 公司深耕重组蛋白药物三十余年，赛若金、依普定、白特喜等自有产品构成经营基本盘；近年来公司围绕“创新+国际化”战略持续升级，形成“自有商业化产品+引进产品+自研创新管线”的梯队化产品矩阵。2025年公司实现营业收入15.34亿元，同比增长9.0%；归母净利润1.56亿元，同比增长394.2%，业绩修复逐步兑现，费用优化带动盈利能力改善。 海外商业化平台进入兑现期，“全球选品+全球覆盖”打开增量空间。 公司较早布局国际化，销售及注册区域已覆盖欧盟、巴西、菲律宾、印度尼西亚等五大洲70多个国家和地区，并在德国、巴西、墨西哥、新加坡、哥伦比亚、埃及、越南等地设立区域化运营节点。依托海外注册、准入、渠道和本地化推广能力，公司出海模式由自有产品出口升级为承接国内优质仿制药、生物类似药和特色制剂出海的平台化商业化模式。引进产品已在70余个国家和地区提交约150项注册申请，白蛋白紫杉醇、贝伐珠单抗、英夫利西单抗等品种注册及商业化持续推进，海外业务有望进入滚雪球式放量阶段。 研发投入持续加码，差异化创新管线打开长期空间。 公司依托“3KX”研发技术平台，围绕KX-FUSION蛋白药物、KX-BODY抗体药物及K’Exosome递送平台布局创新管线，覆盖肿瘤、自身免疫、眼科、抗病毒等方向。重点管线中，GB18聚焦GDF-15靶点及肿瘤恶病质方向，有望受益于恶病质高未满足需求及海外同靶点临床PoC验证；GB12通过IL-4Rα/IL-31Rα双通路阻断，切入特应性皮炎“抗炎+止痒”核心需求；GB24围绕TL1A/LIGHT通路布局IBD抗炎及抗纤维化方向；GB10则以VEGF-Trap+Ang-2 VHH融合蛋白探索眼底病长效双靶治疗。公司创新管线虽仍处早期阶段，但差异化设计明确，长期成长空间有望逐步打开。 投资建议：预计2026-2028年营业收入分别为16.45/18.44/ 21.67亿元，归母净利润分别为1.76/1.90/2.16亿元，对应PE分别为22.89/21.18/18.66倍。考虑到自有产品现金流基础稳定、合作商业化进入放量阶段，同时创新药管线具备中长期弹性，给予“买入”评级。 风险提示：商业化推广不及预期，海外出口增长不及预期等。 盈利预测与估值表 目录 报告正文 1. 公司概况 1.1. 发展历程：深耕生物制药三十载，“创新+国际化”引领未来       科兴制药是一家研发、生产、销售一体化的创新型国际化生物制药企业。公司专注于重组蛋白、多功能抗体、靶向递送疗法，聚焦抗肿瘤、自身免疫、抗病毒等治疗领域，围绕未被满足的临床需求，打造新型蛋白、新型抗体、核酸药物等前沿生物技术平台，开发精准治疗及新型靶向递送药物，坚持“创新+国际化”双轮驱动的平台型发展模式，致力于成为高品质生物药领导者，服务全球患者。       重组蛋白领域先行者，“创新+国际化”驱动转型。1989年，公司前身“深圳科兴生物工程公司”成立，成为国内最早开展重组蛋白研发与产业化的企业之一。1996年，赛若金（人干扰素α1b）获批上市，开创国内基因工程药物市场先河。随后，依普定（人促红素注射液）于1998年获批上市，白特喜（人粒细胞刺激因子注射液）于1999年获批，常乐康（酪酸梭菌二联活菌）于2001年获批，奠定了公司在细分领域的领先地位。2008年，正中集团开始收购，经过战略梳理和团队重整，建立了稳固的国内外市场基础。至2020年底，科兴制药成功登陆科创板（股票代码688136.SH），明确提出“创新+国际化”双轮驱动的发展方向。       创新引领未来，海外商业化及自研创新管线同步布局。近年来，公司持续加大创新药研发投入，推进创新管线建设，并在生物类似药及原研创新药领域取得多项成果。通过引进产品、海外商业化及自研创新管线布局，科兴制药正稳步向国际化生物制药平台型公司转型，为全球患者提供高品质创新药物。 1.2. 股权结构稳定，多元激励机制助力长期发展       公司股权结构清晰稳定。实际控制人邓学勤先生通过深圳科益医药控股有限公司间接控制公司。截至2026Q1，深圳科益医药控股有限公司持有公司9962.58万股，持股比例为49.50%，为公司控股股东；邓学勤先生直接持有公司176.41万股，持股比例为0.88%。公司披露，深圳科益医药控股有限公司为邓学勤先生控制的企业，邓学勤先生为公司实际控制人，二者合计对应持股比例约50.38%，控制权结构清晰稳定。 1.3. 研发团队：核心专家牵头，研发队伍持续扩充       公司研发团队由具备国际化药企研发经验的核心专家牵头，覆盖新药发现、抗体工程、蛋白药物开发、工艺转化及注册申报等关键环节。医药研究院院长秦锁富博士拥有35年药物研发与产业化经验，曾任长春金赛药业研究院副院长、美国Allergan Inc.制药公司首席科学家，并曾在美国国立卫生研究院、日本神户大学及福井大学任职，擅长新药发现和技术平台搭建。其主导构建了公司“3KX”技术平台，累计申请发明专利超60项、授权超20项，并参与制定多项行业技术标准。公司新药研究中心负责人李会铭博士毕业于美国耶鲁大学，具备24年国际药企与学术机构经验，曾任Acceleron Pharma首席科学家、BMS高级研究员，主导或参与Reblozyl、Winrevair、Opdivo等重磅药物及临床阶段项目，并搭建AI驱动的KX-BODY抗体平台，具备丰富的抗体研发和蛋白类药物早期研发经验。       研发团队持续扩充，研发实力不断增强。截至2025年，公司研发人员数量为161人，较上年增加23人，占公司总人数比例提升至15.36%；其中博士研究生23人、硕士研究生84人，本科及以上学历人员占比较高，团队专业背景扎实。公司研发人员薪酬合计5327.79万元，体现出公司对研发人才体系建设的持续投入。 1.4. 产品矩阵：自有产品夯实基础，引进产品贡献增量，“3KX”平台支撑创新       公司现有产品线覆盖抗病毒、血液、消化、肿瘤、自身免疫、代谢病等多个治疗领域。自有产品方面，公司目前已有6个产品获批上市，核心品种包括赛若金、依普定、白特喜、常乐康、克癀胶囊和赛甘苏，其中赛若金、依普定、白特喜等重组蛋白药物已形成较稳定的临床应用基础和品牌认知，是公司当前经营基本盘的重要组成部分。       引进产品方面，公司依托多年海外商业化经验，持续推进“全球选品、全球覆盖”战略。通过获取海外商业化权益，将国内优质仿制药、生物类似药及特色制剂推向国际市场。截至2026Q1，公司引进产品已在70余个国家和地区提交约150项注册申请，覆盖肿瘤、自身免疫、抗病毒、代谢病等多个领域，代表产品包括白蛋白紫杉醇、贝伐珠单抗、英夫利西单抗、阿达木单抗、利拉鲁肽、司美格鲁肽、地舒单抗、阿柏西普等。其中，白蛋白紫杉醇已在欧盟等多个国家和地区实现销售，英夫利西单抗、贝伐珠单抗等品种也在多个新兴市场推进注册及商业化。该模式本质上是公司以海外注册、准入和渠道能力赋能国内药企产品出海，有望持续贡献海外增量。 自研管线方面，公司依托“3KX”研发技术平台，持续布局创新药和生物类似药管线。其中，KX-FUSION蛋白药物技术平台以“PEG修饰+Fc融合”双长效机制为核心，支撑GB05、GB06、GB08、GB-K02等蛋白药物项目；KX-BODY抗体药物技术平台涵盖FIT-BODY抗体发现、FIGHT-BODY双抗设计及FLEX-BODY多功能新型大分子技术模块，支撑GB10、GB12、GB18、GB19、GB20、GB23、GB24、GB25、GB26、GB27等抗体类创新药项目；K’Exosome药物递送技术平台则围绕工程化外泌体递送，应用于GB13等项目。 从治疗领域看，肿瘤领域创新研发重点布局GB18、GB23、GB25、GB27等项目。其中GB18聚焦GDF-15靶点和肿瘤恶病质方向；自身免疫领域布局GB12、GB19、GB20、GB24、GB26等项目，覆盖IL-4R/IL-31、BDCA2、TL1A、TL1A/LIGHT等热门靶点；抗病毒、血液及其他领域则布局GB05、GB06、GB08、GB10、GB13等项目。整体来看，公司产品矩阵兼具成熟产品现金流、引进产品海外放量弹性以及自研管线长期成长空间，产品结构正由传统重组蛋白药物逐步向国际化、多领域、平台型生物制药体系升级。2024公司在肿瘤、自身免疫、退行性疾病及核酸药物等方向持续拓展差异化管线。 1.5. 财务表现：业绩修复逐步兑现，费用优化支撑盈利改善       2025年业绩修复兑现，收入端恢复增长，利润端修复明显。2022-2025年，公司营业收入分别为13.16亿元、12.59亿元、14.07亿元、15.34亿元，2024-2025年同比增速分别为11.7%、9.0%，收入端已逐步回到增长轨道。利润端看，2022-2025年公司归母净利润分别为-0.90亿元、-1.90亿元、0.31亿元、1.56亿元，2024年实现扭亏，2025年同比增长394.2%，盈利能力显著修复。扣非归母净利润方面，2022-2025年分别为-0.97亿元、-2.01亿元、0.35亿元、0.56亿元，2025年同比增长58.4%，反映主营经营质量同步改善。2026Q1，公司实现营业收入2.81亿元，同比下降20.7%；归母净利润-0.18亿元，短期受收入确认节奏、产品结构及费用投入影响有所承压，但全年看公司收入基本盘及合作商业化品种放量逻辑仍在延续。 盈利能力显著提升，利润弹性有待释放。2025年公司销售费用率、管理费用率、研发费用率分别为37.4%、6.1%、13.0%，分别同比变动-5.0、0.0、+1.0个百分点，其中销售费用率下降是利润修复的重要驱动。2026Q1销售费用率、管理费用率、研发费用率分别为40.2%、6.3%、12.1%，单季度盈利表现受收入确认节奏、产品结构及研发投入影响有所波动。后续随着合作商业化产品放量、自有产品收入企稳及创新药研发节点推进，公司利润弹性有望逐步释放。 自有产品构成收入基本盘，合作商业化产品贡献增量。分产品看，公司传统自有品种仍是收入主要来源。2025年，依普定、赛若金、白特喜、常乐康收入分别为6.87亿元、2.69亿元、1.58亿元、1.25亿元，合计收入12.39亿元，占公司总收入比重约80.8%。其中依普定作为核心品种，受益于医保准入、指南推荐及海外注册推进，预计仍将保持稳健增长；赛若金、白特喜及常乐康则以存量市场维护和稳定贡献为主。合作商业化产品方面，2025年收入约2.95亿元，占总收入比重提升至19.2%，随着白蛋白紫杉醇、贝伐珠单抗、英夫利西单抗等品种在新兴市场持续注册及商业化推进，该板块有望成为未来收入增长的重要来源。 2. 全球选品+全球覆盖，海外商业化平台进入兑现期 2.1. 海外医药市场空间广阔，中国药企出海具备产业趋势基础 全球医药市场规模持续扩容，中国药企出海空间广阔。根据弗若斯特沙利文数据，全球医药市场规模由2018年的1.27万亿美元增长至2022年的1.50万亿美元；弗若斯特沙利文预计，2026年、2030年将分别达到1.83万亿美元和2.09万亿美元。海外市场在支付能力、药品价格体系、监管规则和疾病谱结构上与国内市场存在差异，欧美等成熟市场具备较高医疗支付水平和药品定价空间，而东南亚、拉美、中东、非洲等新兴市场则受益于人口增长、慢病负担提升、医疗可及性改善及仿制药/生物类似药需求增加，成为国内药企拓展海外业务的重要方向。 从区域结构来看，欧美市场是中国药企出海的重要高价值市场。其核心吸引力在于较强的医疗支付能力、较高的药品定价水平以及规范化的监管体系。美国仍是全球医药创新和商业化的核心市场，但近年来受贸易摩擦及供应链重构影响，中国医药产品对美出口有所波动；相比之下，欧洲市场在法规准入、质量体系认证和商业化验证方面的重要性持续提升。根据中国医药报数据，2025年我国对欧盟及英国医药出口额达269.6亿美元，同比增长11%，与欧盟及英国医药贸易额达728.5亿美元，占我国医药贸易总额的36.1%，为我国最大的医药贸易伙伴区域。根据中国医药报数据，2025年我国对美国医药出口额达170.3亿美元，同比减少10.2%，占我国医药贸易总额15.2%，美国仍为我国最大的医药贸易国。整体来看，欧美市场虽然准入门槛较高，但一旦实现注册和销售突破，有助于提升中国药企产品质量背书和国际化品牌认知。 新兴市场是中国药企出海更具可复制性的增量来源。东南亚、中东、拉美等地区人口基数较大，医疗资源供给和药品可及性仍有提升空间，同时随着居民收入提升、医保覆盖扩大及疾病谱变化，抗感染、肿瘤、代谢病及慢病管理类用药需求持续释放。根据中国医药报数据，2025年我国与东盟医药贸易额达179.4亿美元，同比增长5.1%；与共建“一带一路”国家医药贸易额达641.7亿美元，同比增长7.2%，显示新兴市场已成为中国医药产品出海的重要承接区域。相较欧美市场，新兴市场在高性价比仿制药、生物类似药及成熟治疗方案方面需求更为明确，也更适合具备注册、准入和本地渠道能力的中国药企进行平台化复制。 非洲市场仍处于医药体系建设和药品可及性提升阶段，长期增长潜力较为明确。除传染病、抗感染等基础用药需求外，随着城市化推进和慢病负担上升，肿瘤、糖尿病、心血管等治疗领域的用药需求也在逐步释放。对于中国药企而言，非洲市场更强调产品可及性、价格优势和稳定供应能力，适合以成熟仿制药、生物类似药和基础治疗药物切入，并通过多国注册经验和本地渠道资源实现长期布局。 2.2. 海外商业化闭环，平台化出海能力持续兑现 中国药企出海的底层逻辑从早期单一产品出口，逐步演变为围绕注册、准入、渠道和本地化运营的系统性能力输出。在此背景下，科兴制药已逐步形成“全球选品、全球覆盖”的海外商业化平台。公司较早启动国际化进程，早于2000年即实现海外销售，经过二十余年海外注册、准入及渠道建设积累，目前销售及注册区域已覆盖欧盟、巴西、菲律宾、印度尼西亚等五大洲70多个国家和地区，其中已实现对人口过亿新兴国家市场的全面覆盖。        在海外组织和本地化能力方面，公司已逐步搭建覆盖重点区域的运营网络。根据公司管理层材料，公司已在德国、巴西、墨西哥、新加坡、哥伦比亚、埃及及越南设立附属公司或分支机构，作为辐射欧洲、拉美、东南亚、中东北非等市场的战略枢纽。药品出海并非简单出口销售，而是需要完成目标市场注册申报、GMP审计、市场准入、渠道建设及本地化推广等多环节工作。公司通过本地化团队和区域枢纽提升对当地监管、渠道和终端市场的响应能力，为后续多产品、多国家同步推进注册和销售提供组织支撑。 在此基础上，公司出海模式进一步从自有产品出口升级为“全球选品+全球覆盖”的海外商业化平台。通过与国内药企合作，取得优质仿制药、生物类似药及特色制剂的海外商业化权益，并利用自身海外注册和商业化能力推动产品进入国际市场。该模式本质上是以科兴既有海外体系承接国内药企产品出海需求，形成从“产品出口”到“平台化商业化运营”的升级。 2.2. 引进产品注册持续推进，海外商业化进入滚雪球阶段       在海外商业化平台搭建完成后，公司出海业务的核心观察点转向产品注册和销售兑现。公司引进产品已从早期签约储备阶段，逐步进入多国注册受理、获批上市和商业化放量阶段。公司选品原则聚焦高技术含量、高市场价值、高国际注册水准及可快速商业化的产品，截至2026Q1已与24家企业合作，取得27个产品海外商业化权益，并同步推进数十个国家的逾百项注册申请。 白蛋白紫杉醇是公司引进产品中最具代表性的率先兑现品种。该产品可用于转移性乳腺癌、非小细胞肺癌、转移性胰腺癌等多种肿瘤，临床应用基础较广。截至2026Q1，Apexelsin已实现35个国家市场准入，横跨欧洲、亚洲及南美洲；根据公司2025年年报，截至2025年上半年其在国内同类产品出口量中占比47.7%，排名第二。欧洲白蛋白紫杉醇市场亦具备较好增长空间，2024年市场规模约7亿美元，预计2030年增长至14亿美元，CAGR为12.2%。因此，白蛋白紫杉醇不仅验证了公司进入欧洲法规市场的能力，也成为公司海外收入增长的重要牵引品种。 除白蛋白紫杉醇外，公司多个引进品种的注册及获批进展正在形成后续梯队。贝伐珠单抗已在秘鲁、印度尼西亚、巴基斯坦及孟加拉国获批，并在巴西、马来西亚、菲律宾等近20个国家和地区获得受理；英夫利西单抗已在尼日利亚、巴基斯坦、哥伦比亚、印度尼西亚、玻利维亚获批，并在巴西、智利、墨西哥等20多个国家和地区获得受理；索拉非尼已在埃及、秘鲁获批，阿达木单抗、利拉鲁肽、碳酸司维拉姆等产品亦在多个国家递交申请。多个品种同步推进，有助于公司海外业务从单品驱动逐步转向多产品接力。 从产品结构看，公司引进品种多数对应已被验证的成熟靶点或成熟治疗方案。因此，产品具备较明确的海外临床需求和参照市场，更适合作为海外平台模式下的首批放量资产。肿瘤领域产品既包括白蛋白紫杉醇、艾立布林等化疗及微管抑制剂，也包括贝伐珠单抗、曲妥珠单抗等生物类似药，以及索拉非尼、奈拉替尼、哌柏西利、奥拉帕利等小分子靶向药，可覆盖乳腺癌、非小细胞肺癌、胰腺癌、结直肠癌等多个高发癌种；自免领域的英夫利西单抗、阿达木单抗则对应TNF-α通路，在类风湿关节炎、炎症性肠病、银屑病等慢病治疗中具备成熟应用基础；代谢病领域的利拉鲁肽、司美格鲁肽则受益于全球糖尿病及体重管理需求增长。随着白蛋白紫杉醇率先跑通欧洲及新兴市场销售，后续贝伐珠单抗、英夫利西单抗、阿达木单抗等产品若持续获批并进入放量阶段，公司海外收入有望从单一品种贡献，逐步转向多品种、多区域驱动。 3.研发投入持续加码，差异化创新管线打开长期空间 3.1. 研发投入与团队建设持续加强，推进创新管线布局       公司近年来持续向创新驱动型药企转型，研发投入保持高强度。2022-2025年，公司研发投入（包括资本化及费用化研发投入）分别为1.93亿元、3.45亿元、1.99亿元和2.51亿元，2025年同比增长26.38%；2026Q1单季度研发投入（包括资本化及费用化研发投入）为5052万元，同比增长20.5%。研发投入的恢复增长，主要服务于公司创新药管线临床推进、核心技术平台建设及海外注册研发支持等方向。从投入节奏看，公司已经从传统重组蛋白产品的改良和生产工艺优化，逐步转向创新抗体、长效蛋白及新型递送平台相关项目的系统性开发。 研发团队方面，公司已形成由资深科学家牵头、硕博人才为核心的研发组织体系。根据2025年报，公司研发人员数量为161人，较上期增加23人。学历结构上，公司研发团队中博士研究生23人、硕士研究生84人，硕博合计107人，占研发人员比例约66%；年龄结构上，30—40岁研发人员为113人，是研发团队主体，体现出公司研发队伍兼具专业基础和成长活力。研发团队扩充与高学历人才储备，为公司多条创新药管线同步推进提供了人力支撑。       公司在研管线围绕高临床需求领域展开，形成“临床后期品种+早期创新管线”布局。截至目前，公司共有15条在研产品管线，其中包括12款创新药，2款管线已进入临床III期、4款在临床I/II期，另有多款处于IND/临床前阶段。从技术平台看，公司在研项目主要依托KX-FUSION蛋白药物技术平台和KX-BODY抗体药物技术平台推进，前者侧重于长效蛋白药物和改良型生物制品开发，后者则支撑公司在双抗、多功能抗体及肿瘤、自免创新药方向的布局。整体来看，公司研发管线已从传统重组蛋白产品延展至创新抗体、长效蛋白及新型递送等方向，创新属性逐步增强。 创新药临床后期项目方面，GB05和GB06是公司当前进度较靠前的两条管线。GB05为人干扰素α1b突变体吸入溶液，拟用于小儿RSV下呼吸道感染，采用雾化吸入给药方式，具备局部给药浓度高、全身暴露较低、患儿依从性较好的特点，目前已在中国启动III期临床，并获得美国FDA IND批准，同时于2025年被CDE纳入突破性治疗品种名单。GB06为生长激素受体相关生物类似药，拟用于儿童生长激素缺乏症，目前处于中国临床III期阶段。两款临床后期产品一方面有望为公司中期产品接续提供支撑，另一方面也体现公司在蛋白药物长效化、剂型改良及差异化临床应用场景上的研发积累。 3.2. GB18：GDF-15 单抗，恶病质未满足需求高 3.2.1. 肿瘤恶病质高发且缺乏有效靶向药，临床需求明确 肿瘤恶病质高发且治疗手段有限，机制型靶向干预存在明确临床空白。肿瘤恶病质是晚期恶性肿瘤常见并发症之一，主要表现为非自主性体重下降、食欲减退、骨骼肌消耗、活动能力下降及全身代谢紊乱，不仅显著影响患者生活质量，也会降低抗肿瘤治疗耐受性，并与较差的生存结局相关。据弗若斯特沙利文数据，约 60%–80% 的癌症患者会发展为恶病质，约 20% 的癌症患者直接死于恶病质及其并发症，而非肿瘤本身。 现阶段，中国肿瘤恶病质临床管理仍以营养支持、孕激素治疗、物理治疗及综合康复计划为主，整体疗效有限，难以从疾病机制层面逆转体重下降和肌肉消耗进程；海外虽已有 GHSR 激动剂阿那莫林在日本获批，可通过刺激食欲中枢改善食欲和体重，但其对肌力及功能终点改善有限，FDA 和 EMA 尚未批准其上市。 从市场空间看，根据弗若斯特沙利文数据，中国癌症恶病质相关药物市场预计由2019年的29亿元增长至2024 年的63亿元，并有望于2030年达到132亿元，2019—2024年及2024—2030年 CAGR 分别为 17.0% 和 13.3%。在中美尚无针对肿瘤恶病质靶向药物获批、现有治疗更多停留于支持和对症干预的背景下，能够从机制层面改善体重、肌肉功能及活动能力的创新药物具备较高开发价值。 3.2.2.全球恶病质创新药仍处早期，GDF-15/GFRAL通路凭借临床PoC与机制优势率先突围 全球恶病质创新药管线仍处早期，GDF-15/GFRAL 通路临床验证基础相对领先。从全球在研格局看，癌症恶病质药物开发仍主要集中于食欲调控、能量代谢及炎症消耗相关通路，包括 GHSR、GDF-15/GFRAL、MC3R/MC4R 等方向。其中，传统 GHSR 激动剂更多聚焦食欲和体重改善，而GDF-15/GFRAL 通路通过调节食欲抑制、体重下降和能量代谢失衡，已成为当前机制验证基础较强的方向。 辉瑞 Ponsegromab 是全球进展最快的GDF-15单抗之一。目前已在GDF-15升高的癌症恶病质患者中取得II期积极数据，并启动后续IIb/Ⅲ期临床研究，为同靶点药物开发提供了临床PoC。相比之下，除Ponsegromab外，多数恶病质创新药仍处于 I/II 期阶段。 GDF-15 通过中枢食欲调控与外周代谢重编程共同驱动恶病质进展，并可能参与肿瘤免疫抑制。GDF-15（Growth differentiation factor 15）又称 MIC-1，属于 TGF-β 超家族成员，是一种在组织损伤、炎症、肿瘤及治疗应激状态下显著升高的分泌型细胞因子。生理状态下，GDF-15可参与食欲、体重和能量代谢调节；在肿瘤微环境中，肿瘤细胞可分泌GDF-15，并经循环作用于脑干后区（area postrema, AP）及孤束核（nucleus tractus solitarius, NTS）中表达的GFRAL受体，进一步募集RET共受体并激活下游信号通路，从而诱导食欲下降、恶心、体重降低等恶病质相关症状。同时，GDF-15-GFRAL 信号可增强交感神经输出，影响脂肪组织、肝脏和骨骼肌代谢，促进脂解、糖异生和蛋白分解，最终导致脂肪丢失、肌肉容量下降、体能下降和体重减轻。 除代谢作用外，GDF-15还可能通过旁分泌方式作用于肿瘤微环境。GDF-15抑制树突状细胞成熟及CD8+ T细胞浸润和活化，并与MDSC、Treg等免疫抑制细胞相关因子共同促成免疫逃逸。因此，GDF-15靶向治疗的潜在价值不止于改善食欲和体重，更在于能从上游阻断恶病质相关的中枢—外周代谢轴，并抑制潜在的免疫逃逸信号，从而改善患者体能和免疫治疗耐受性。 辉瑞 Ponsegromab II期结果验证GDF-15通路具备临床转化基础。Ponsegromab是辉瑞开发的抗GDF-15单抗，其II期随机双盲研究纳入187例癌症恶病质且血清GDF-15升高的患者，主要覆盖非小细胞肺癌、胰腺癌和结直肠癌，采用100mg、200mg、400mg或安慰剂每4周皮下注射一次、共治疗12周。 研究结果显示，Ponsegromab各剂量组均较安慰剂实现更高体重增长。100mg、200mg 和400mg组相较安慰剂的中位体重差异分别为1.22kg、1.92kg和2.81kg，呈剂量相关趋势；400mg组还在食欲/恶病质症状及数字化活动能力指标上观察到改善，且不良事件发生率与安慰剂相近。基于该研究，GDF-15抑制已完成从机制假设到临床PoC的关键验证，说明该通路不仅能够影响体重，也具备向症状和活动能力改善转化的潜力。辉瑞目前已进一步启动Ponsegromab联合一线化疗用于转移性胰腺导管腺癌合并恶病质患者的IIb/III期研究，进一步强化GDF-15靶点在恶病质治疗中的验证地位。 3.2.3. GB18：VHH-Fc 结构，临床前试验验证体重与肌肉改善潜力 GB18 是科兴制药布局癌症恶病质的GDF-15 单抗，采用 VHH-Fc 融合结构。GB18-06由人源化抗GDF-15纳米抗体与人IgG1 Fc片段融合而成，分子量约80kDa，在保留Fc端半衰期优势的同时，具备纳米抗体分子量较小、稳定性较好、溶解度较高和工程化开发便利等特点。临床前研究显示，GB18-06能够特异性结合多物种GDF-15，并在配体-受体阻断实验及细胞功能实验中抑制GDF-15-GFRAL-RET 介导的 ERK、AKT 下游磷酸化信号，体外中和活性与同靶点对照抗体处于可比水平。       从药效维度看，GB18 的临床前数据不止停留在体重恢复，而是进一步延伸至肌肉组织和活动能力改善。在HT-1080人纤维肉瘤、Renca小鼠肾癌、MC38小鼠结肠癌等多种肿瘤恶病质模型中，GB18-06均可改善肿瘤诱导的体重下降；在 HT-1080模型中，GB18-06进一步提高腓肠肌重量、附睾脂肪重量及肌纤维横截面积，提示其对恶病质相关组织消耗具有改善潜力。相较单纯体重增加，肌肉组织改善更贴近恶病质药物未来临床价值判断，也是GB18后续临床验证中值得重点关注的方向。       从给药方式看，VHH-Fc结构为GB18的高浓度皮下和低频给药提供了基础。临床前研究显示，GB18-06在制剂筛选中可浓缩至150mg/mL以上，并在高温、光照、氧化、pH 和反复冻融等压力条件下保持较好的纯度、体外活性和抗原结合能力；食蟹猴皮下注射给药后半衰期约166.7小时，支持其后续向低频皮下注射方案开发。考虑恶病质患者多处于晚期肿瘤治疗阶段，体能状态较差，若GB18后续能够在人体中验证安全性、PK 暴露、免疫原性及高浓度皮下注射可行性，其用药便利性和依从性有望构成重要差异化。 3.3. GB12：IL-4Rα/IL-31Rα双通路阻断，切入特应性皮炎“抗炎+止痒”核心需求 3.3.1. 特应性皮炎患者基数庞大，靶向创新药推动市场持续扩容 特应性皮炎（Atopic Dermatitis，AD）是一类慢性、复发性炎症性皮肤病。主要临床表现为湿疹样皮损、皮肤屏障受损及持续性瘙痒，可伴随睡眠障碍和生活质量下降。既往治疗以外用糖皮质激素、外用钙调磷酸酶抑制剂、口服抗组胺药、系统性免疫抑制剂及糖皮质激素等为主，但在中重度患者的长期疾病控制、持续止痒和安全性管理方面仍存在局限。2024年特应性皮炎药物专家共识指出，近年来生物制剂及多种小分子药物陆续获批用于特应性皮炎治疗，治疗体系正从传统对症和广谱免疫抑制，逐步向靶向炎症通路、改善瘙痒和长期维持管理升级。 流行病学上，特应性皮炎在儿童及婴幼儿中更高发。中国2020版诊疗指南显示，发达国家儿童特应性皮炎患病率可达10%~20%；我国1~7岁儿童患病率由2002年的2.78%提升至2014年的12.94%，1~12个月婴儿患病率高达30.48%，显示儿童疾病负担较重且患病率呈上升趋势。市场空间方面，弗若斯特沙利文数据显示，中国特应性皮炎患者人数由2020年的6740万人增至2024年的7290万人，预计2028年达到7750万人；同期中国特应性皮炎治疗市场规模由2020年的约43亿元增长至2024年的110亿元，预计2028年达到297亿元，对应2024—2028年CAGR为28.1%。整体来看，特应性皮炎市场兼具大患者基数和较快扩容潜力，后续增长主要来自诊疗认知提升、中重度患者治疗需求释放以及创新药物渗透率提升。 3.3.1. 特应性皮炎患者基数庞大，靶向创新药推动市场持续扩容 特应性皮炎发病以2型炎症反应和瘙痒—搔抓循环为核心。过敏原刺激后，抗原递呈细胞可诱导T细胞向Th2细胞分化，并释放IL-4、IL-13等炎症因子，推动IgE升高、炎症细胞募集、上皮增生及皮肤屏障受损，是中重度特应性皮炎皮损反复和疾病迁延的病理基础。IL-4Rα作为IL-4/IL-13信号通路的关键受体亚基，位于特应性皮炎炎症反应的核心环节，因此成为已验证的控炎靶点。 除炎症通路外，瘙痒也是特应性皮炎患者疾病负担的重要来源。IL-31主要由Th2细胞等免疫细胞分泌，可通过IL-31Rα相关受体复合物激活感觉神经通路，诱发瘙痒并进一步导致搔抓、屏障破坏和炎症加重。由此看，特应性皮炎治疗不仅需要控制炎症和皮损，也需要缓解瘙痒、减少搔抓带来的疾病循环。IL-4Rα/IL-31Rα双通路阻断的机制基础在于：一端抑制Th2炎症反应，另一端干预IL-31介导的瘙痒信号，从而覆盖特应性皮炎治疗中“炎症”和“瘙痒”两类核心病理环节。 IL-4Rα通路已由Dupixent完成百亿级大单品验证。Dupixent由赛诺菲与再生元共同开发，通过阻断IL-4Rα同时抑制IL-4和IL-13信号，2017年获FDA批准上市后，适应症持续拓展至特应性皮炎、哮喘等多项2型炎症相关疾病。根据赛诺菲2025年年报，Dupixent 2025年全球销售额达157.14亿欧元；其持续放量验证了IL-4Rα通路在2型炎症疾病中的临床价值和商业潜力。但与此同时，Dupixent在特应性皮炎治疗中仍存在一定眼部不良反应问题。临床研究汇总显示，Dupixent单药治疗16周后结膜炎发生率为8.4%，高于安慰剂组的2.3%；在两项Dupixent联合外用糖皮质激素治疗的研究中，结膜炎发生率分别达到17.9%和22.1%，均高于对照组。眼部不良反应可能增加额外疾病负担并影响部分患者长期依从性，后续围绕IL-4Rα通路进行机制升级仍具备明确临床意义。 3.3.3.GB12：双靶点阻断兼顾控炎与止痒，差异化设计提升临床应用潜力 GB12为科兴制药自研IL-4Rα/IL-31Rα双特异性抗体，聚焦特应性皮炎。GB12同时覆盖特应性皮炎治疗中的两类核心病理环节：一方面通过阻断IL-4Rα，抑制IL-4/IL-13介导的Th2炎症反应，从而降低IgE生成、炎症因子释放及皮肤屏障损伤；另一方面通过阻断IL-31Rα，干预IL-31介导的神经瘙痒通路，减少瘙痒和搔抓所导致的炎症放大。该双通路设计有望在维持控炎疗效的同时强化止痒效果，并在理论上减少对高强度IL-4Rα抑制的依赖，从而降低IL-4Rα相关眼部不良反应风险，更契合中重度特应性皮炎患者对长期疗效和用药耐受性的综合需求。       公开体外数据验证GB12系列具备IL4Rα/IL31Rα双通路阻断能力。科兴团队在 Antibody Therapeutics发表的研究中披露，GB12采用IgG-scFv 双抗结构，以 IL4Rα 抗体为 IgG 主体，并在重链 C 端连接 IL31Rα scFv，从而同时靶向 IL4Rα 和 IL31Rα；设计上通过调整 IL31Rα scFv 的 VL-VH 顺序并引入 VH44-VL100 二硫键提升 scFv 稳定性。体外桥联ELISA 显示，GB12-09可同时结合 hIL4Rα 和 hIL31Rα；细胞功能实验中，GB12-09可有效阻断IL4、IL13及IL31信号，其中对 IL4/IL13的抑制效果与IL4Rα单抗相近，并可抑制IL31依赖的细胞增殖。由此看，公开体外数据支持GB12系列通过IL4Rα/IL31Rα双靶点设计，同时覆盖特应性皮炎中Th2炎症和瘙痒信号两类核心病理环节。       IL-4Rα/IL-31相关特应性皮炎双抗仍处早期开发阶段，全球资产数量有限。NM26曾获强生收购并推进至临床中期，但后续因疗效不足终止，显示该机制虽具备BD价值，仍需临床数据验证增量获益；目前GB12处于临床前阶段，若后续IND及早期临床顺利推进，有望在低拥挤度赛道中形成差异化布局。 3.4. GB24：TL1A/LIGHT双靶点布局，探索IBD抗炎与抗纤维化联合干预 3.4.1. IBD患者基数持续扩容，市场规模持续扩大 炎症性肠病（Inflammatory Bowel Disease，IBD）是一组慢性或缓解-复发性的肠道炎症性疾病。IBD主要包括溃疡性结肠炎（Ulcerative Colitis，UC）和克罗恩病（Crohn’s Disease，CD）。UC通常表现为从直肠起始、连续累及结肠黏膜的弥漫性炎症，并可形成糜烂或溃疡；CD则可累及从口腔到肛门的任意消化道部位，病变常呈非连续分布，并具有全层炎症、肉芽肿及瘘管等特征。 全球IBD患者规模持续扩容，市场规模持续扩大。Lancet Gastroenterol Hepatol的一项系统性分析显示，1990—2017年全球IBD患病人数由约370万人增至超过680万人，增长85.1%；中国虽仍低于欧美成熟市场，但发病率上升更快，1990—2019年总人群粗发病率由1.45/10万人升至3.62/10万人，标化发病率由1.47/10万人升至3.01/10万人。市场规模上，2024年全球IBD治疗市场规模为221.4亿美元，预计2030年增至277.3亿美元，2024—2030年CAGR为3.8%。 IBD兼具患者规模扩容、长期慢病管理和先进疗法持续迭代三重属性。市场增长不只来自新增患者，更来自中重度患者、生物制剂经治患者及长期维持治疗场景下仍未满足的临床需求。 3.4.2. 现有疗法持续迭代但仍存在不足，TL1A成为IBD新一代机制突破方向 IBD现有治疗已形成多机制并行格局。以中重度UC为例，美国胃肠病学会（AGA）2024年指南已将整合素抑制剂、JAK抑制剂、S1P调节剂、IL-12/23及IL-23相关抗体等先进疗法纳入推荐，代表药物包括乌帕替尼、英夫利西单抗、乌司奴单抗、托法替布、戈利木单抗、巴瑞替尼等。IBD治疗已从传统抗炎/免疫抑制逐步进入生物制剂与小分子靶向药并行阶段。 现有疗法仍难以完全满足长期治疗需求。以抗TNF药物为例，其虽是IBD治疗中应用最成熟的生物制剂之一，但仍存在原发无应答和继发失应答问题：文献显示，约三分之一接受抗TNF-α治疗的IBD患者为原发无应答，接近一半初始应答患者后续可能出现继发无应答，提示现有生物制剂在缓解深度和疗效持续性上仍存在提升空间；JAK抑制剂等小分子药物虽为经治患者提供新选择，但其严重心血管事件、肿瘤、血栓等安全性风险受到FDA黑框警告提示。整体来看，IBD治疗仍需要在疗效持续性和长期安全性之间取得更优平衡，新机制药物具备明确补位空间。 TL1A有望成为IBD新一代热门靶点。TL1A全称为肿瘤坏死因子样配体1A（Tumor necrosis factor-like ligand 1A），属于TNF超家族成员；其主要受体DR3全称为死亡受体3（Death receptor 3），属于TNF受体超家族。TL1A与DR3结合后，可放大T细胞相关免疫反应，促进Th1/Th17炎症通路活化，并参与肠道黏膜炎症维持。近年来研究进一步显示，TL1A/DR3轴不仅与免疫激活相关，还与上皮屏障功能障碍、基质细胞活化、细胞外基质重塑及肠道纤维化过程相关，因此被认为是连接“炎症—组织损伤—纤维化进展”的关键调节通路。 临床端，TL1A靶点已获得早期疗效验证。抗TL1A单抗tulisokibart在中重度UC II期研究中达到主要终点：治疗12周时，tulisokibart组临床缓解率为26%，显著高于安慰剂组的1%；同时，tulisokibart组内镜改善率为37%，亦显著高于安慰剂组的6%。此外，tulisokibart在临床应答、组织学改善、组织学-内镜黏膜改善、黏膜愈合及IBDQ应答等关键次要终点上均较安慰剂组显示改善，提示TL1A通路阻断不仅可改善临床症状，也具备推动肠黏膜炎症改善的潜力，初步验证了TL1A作为IBD治疗靶点的可行性。 TL1A赛道热度高，相关资产受MNC青睐。2023年，默沙东以约108亿美元收购Prometheus Biosciences，获得tulisokibar权益；同年，赛诺菲/梯瓦围绕duvakitug达成最高15亿美元合作，罗氏以71亿美元预付款收购Telavant并获得RVT-3101权益，艾伯维以1.5亿美元首付款、最高15.6亿美元里程碑引进明济生物TL1A抗体FG-M701；2025年，赛诺菲进一步获得Earendil Labs两款TL1A双抗HXN-1002（TL1A×α4β7）和HXN-1003（TL1A×IL-23p19）全球独家权利。MNC频繁交易显示，TL1A已从靶点验证进入资产争夺阶段，双抗及下一代组合机制正成为MNC布局重点。 3.4.3.GB20/GB24：单抗验证TL1A通路，双抗延伸IBD抗炎与纤维化干预空间 公司在IBD方向布局GB20和GB24两条TL1A相关管线，形成“单抗切入+双抗差异化”的产品组合。其中，GB20为TL1A单抗；GB24则为TL1A/LIGHT双特异性抗体，在TL1A抗炎机制基础上进一步引入LIGHT相关通路，定位于同时覆盖肠道炎症维持与慢性炎症后的组织重塑、纤维化过程。 GB24的差异化主要来自LIGHT靶点的引入。LIGHT又称肿瘤坏死因子超家族成员14（TNF superfamily member 14），可由粒细胞、巨噬细胞等炎症细胞信号诱导，并作用于上皮细胞、平滑肌细胞和成纤维细胞等结构细胞，促进IL-8、collagen、fibronectin等炎症及纤维化因子表达。在IBD中，LIGHT通路可能参与慢性炎症后的成纤维细胞活化、细胞外基质沉积和肠壁纤维化进展。因此，LIGHT通路为GB24在TL1A抗炎基础上进一步覆盖组织重塑和纤维化过程提供机制支撑。 竞争格局上，TL1A双/多抗研发整体仍处早期，为新崛起的蓝海市场。GB24选择TL1A/LIGHT组合切入IBD，机制上突出“抗炎+抗纤维化”，在早期TL1A双抗赛道中具备差异化定位。TL1A / LIGHT双抗目前仅科兴及Virtici在研，且均处于临床前阶段。 3.5. GB24：TL1A/LIGHT双靶点布局，探索IBD抗炎与抗纤维化联合干预 3.5.1. IBD患者基数持续扩容，市场规模持续扩大 眼底血管增生性疾病病程长、易复发，持续进展可导致不可逆视力损伤。主要包括新生血管性年龄相关性黄斑变性（nAMD）、糖尿病视网膜病变/糖尿病黄斑水肿（DR/DME）及视网膜静脉阻塞（RVO）等。弗若斯特沙利文数据显示，2024年中国眼底血管增生疾病患者人数超过4,000万，且随人口老龄化仍在持续上升；DataBridge预测，到2030年全球眼科医疗市场总规模将达1,026亿美元，其中糖尿病视网膜病变、黄斑变性和年龄相关性黄斑变性市场容量预计超过300亿美元。 抗VEGF药物为标准治疗方案，但频繁注射与疗效不足仍是核心痛点。目前眼底血管增生性疾病的一线治疗以玻璃体腔内注射抗VEGF药物为主。VEGF即血管内皮生长因子，可促进血管内皮细胞增殖、迁移和新生血管形成，并增加血管通透性；在nAMD、DME、RVO等疾病中，VEGF过度表达会诱发脉络膜或视网膜异常新生血管、黄斑水肿及渗漏，是视力下降的重要病理基础。抗VEGF药物通过抑制异常血管生成和渗漏，改善视网膜水肿及视力预后。 患者依从性成为临床应用主要痛点。由于眼底疾病具有慢性、复发性特征，患者往往需要长期随访和多次玻璃体腔注射，治疗负担较重，依从性容易下降；同时，部分患者对单一VEGF抑制应答不足，仍存在水肿残留、渗漏复发或视力改善有限等问题。因此，延长给药间隔、提升血管稳定性控制，并通过VEGF/Ang-2等多通路干预改善长期疗效，成为眼底病治疗的重要升级方向。 3.5.2. Faricimab验证VEGF/Ang-2双靶点眼科治疗路径 Faricimab（商品名VABYSMO）是罗氏开发的VEGF-A/Ang-2双特异性抗体，已获批用于nAMD、DME及RVO等眼底疾病。除VEGF-A 驱动异常血管新生和渗漏外，Ang-2是Tie-2血管稳定通路的重要调节因子，在眼底病变中上调后可削弱血管屏障、增加血管对 VEGF信号的敏感性，并加重渗漏和炎症反应。Faricimab通过同时抑VEGF-A和Ang-2，在抗VEGF控制新生血管的基础上，进一步强化血管稳定性和渗漏控制，为后续双靶药物提供了机制参照。       Faricimab的优势主要体现为疗效不低于标准抗 VEGF 药物，同时支持更长给药间隔。在nAMD III期研究中，Faricimab最长可按16周给药，48周最佳矫正视力改善（BCVA）约+5.8/+6.6个ETDRS 字母，与阿柏西普q8w的+5.1/+6.6个字母相当；RVO研究中，Faricimab 24周视力改善同样不劣于阿柏西普，并在黄斑渗漏消失比例上显示更优趋势。相较于标准抗VEGF药物，Faricimab在维持疗效基础上，通过双靶机制实现更长效、更好的渗漏控制。 商业化层面，Faricimab获批后快速放量。罗氏年报显示，Faricimab 2025年全球销售额达到41.02亿瑞士法郎，同比增12%，已成为罗氏眼科管线的核心增长品种。相比之下，传统VEGF单靶代表药物阿柏西普仍具备较大市场体量，但正面临双靶长效药物、高剂量长效剂型及生物类似药的竞争压力；再生元披露，2025年其阿柏西普产品线中，普通规格EYLEA与高剂量长效规格EYLEA HD在美国合计销售额为44亿美元，同比下降27%，显示眼底病市场竞争正加速向长效化和给药便利性升级。 3.5.3. GB10：VEGF-Trap+Ang-2 VHH融合蛋白，探索眼底病长效双靶治疗       GB10 是公司自主开发的VEGF/Ang-2 双靶点抗体融合蛋白，聚焦眼底血管增生性疾病的长效治疗。与Faricimab采用VEGF-A/Ang-2的1+1双特异性抗体设计不同，GB10采用VEGF-Trap+Ang-2 VHH的2+2对称融合蛋白结构。其中，VEGF-Trap可覆盖VEGF-A，VEGF-B和PlGF等VEGF家族相关配体，较单纯抗VEGF-A抑制范围更广；Ang-2 VHH结构小、易融合，有利于形成稳定的双靶分子。该设计使 GB10 可同时干预异常血管生成和血管稳定性破坏，为高浓度长效制剂开发提供基础。      临床前数据为GB10长效化开发提供初步证据支撑。研究论文显示，GB10制剂浓度达到140mg/mL，高于Faricimab的120mg/mL；兔眼玻璃体药代研究中，GB10半衰期为59.4h，长于Faricimab的39.6h，提示其具备提高单次给药暴露、延长眼内作用时间的潜力。动物试验方面，GB10在激光诱导的猴 CNV模型及兔RNV模型中均显示出对眼底异常新生血管的抑制作用。       竞争格局方面，同类产品竞争仍相对有限。罗氏Faricimab是唯一已获FDA及NMPA批准的 VEGF/Ang-2双抗；中国目前共有8条同类管线，除 XMVA09、EXG202、Y400 处于 I/II 期外，其余多处于I期，尚未出现上市品种。GB10 已于 2026 年 5 月完成 I 期临床首例受试者入组给药，适应症为 nAMD；其 140mg/mL 高浓度制剂预期实现每 4 个月给药一次。GB10有望凭借VEGF-Trap+Ang-2 VHH的结构差异化、高浓度制剂及长效给药潜力，在VEGF/Ang-2双靶赛道中形成独特竞争优势。 4. 盈利预测与投资评级 4.1. 盈利预测与关键假设 基于公司现有产品矩阵、海外注册推进节奏及合作商业化品种放量情况，我们预计公司2026-2028年营业收入分别为16.45/18.44/21.67亿元，同比增长7.2%/12.1%/17.5%；考虑合作商业化产品收入占比提升，公司综合毛利率分别为64.1%/62.0%/60.4%；归母净利润分别为1.76/1.90/2.16亿元，同比增长13.3%/8.0%/13.5%。 4.1.1.自有产品业务 公司自有产品主要包括依普定、赛若金、白特喜和常乐康，四大品类均具备较长销售历史和稳定临床使用基础，是公司收入和利润的核心基本盘。其中，依普定为公司核心自有品种，受益于医保准入、临床需求稳定及海外注册推进，预计 2026-2028 年收入分别为 7.35/7.94/8.73 亿元，同比增长 7.0%/8.0%/10.0%；赛若金作为成熟干扰素品种，存量需求基础稳定，但市场增长弹性相对有限，预计 2026-2028 年收入分别为 2.29/2.06/2.16 亿元；白特喜和常乐康以存量市场维护和稳定贡献为主，预计 2026-2028 年收入分别为 1.58/1.61/1.68 亿元和 1.25/1.26/1.30 亿元。       我们采用FCFF法对公司进行估值。估值参数方面，假设无风险收益率为1.8%，市场预期收益率为11.0%。考虑到公司仍处于创新药商业化早期，历史股价波动受临床数据、板块情绪及风险偏好影响较大，单纯基于短期历史收益率测算得到的β值可能难以充分反映公司与市场整体的长期波动相关性，因此我们结合历史测算结果及A股创新药行业可比公司情况，取β值为1.01。公司为生物医药高新技术企业，所得税率为15%，计算得到股权资本成本Ke为11.09%，加权平均资本成本WACC为10.52%。考虑到公司核心产品已进入商业化兑现阶段，且后续管线仍具备较大适应症拓展和海外商业化潜力，我们假设模型预测期为5年，过渡期为5年，过渡期增长率为5.0%，永续增长率为2.0%。基于FCFF模型，公司股权价值为245.45亿元，对应目标价为52.77元/股，首次覆盖，给予“买入”评级。 4.1.2.合作商业化业务 合作商业化产品是公司未来三年收入增长的主要来源。公司依托海外注册及商业化能力，围绕肿瘤、自免、代谢等领域布局白蛋白紫杉醇、贝伐珠单抗、英夫利西单抗、阿达木单抗、利拉鲁肽、索拉非尼等多个产品。随着相关品种在新兴市场持续获批、递交注册及商业化放量，该板块收入占比有望持续提升。 2025年，公司合作商业化产品收入约2.95亿元，我们预计2026-2028年收入分别为3.98/5.57/7.80亿元，同比增长35%/40%/40.0%。毛利率方面，由于合作商业化产品通常采用引进及代理销售模式，毛利率低于传统自有品种；但随着收入规模扩大和渠道效率提升，预计该板块毛利率逐步提升至2028年的30.0%。整体看，合作商业化业务将成为公司收入增长的核心变量，但其占比提升也将对综合毛利率形成一定摊薄。 4.2. 投资评级       公司以依普定、赛若金、白特喜、常乐康等自有产品构建稳定收入基本盘，并通过合作商业化业务打开海外市场增量空间。短期看，合作商业化品种在新兴市场注册及销售推进有望驱动收入增长；中长期看，公司围绕GDF-15、VEGF/ANG-2、TL1A 等前沿靶点布局创新药管线，后续临床数据读出及潜在海外授权顺利推进，有望进一步打开估值弹性。 我们预计公司2026-2028年营业收入分别为16.45/18.44/21.67亿元，归母净利润分别为1.76/1.90/2.16亿元，对应PE分别为22.89/21.18/18.66倍。考虑到公司自有产品现金流基础稳定、合作商业化业务进入放量阶段，同时创新药管线具备中长期弹性，给予“买入”评级。 5. 风险提示 商业化推广不及预期。公司核心产品包括白蛋白紫杉醇、英夫利西单抗等，若集采、医保准入、学术推广或终端放量节奏低于预期，以及新产品商业化进展不及预期，将影响公司收入增长和盈利能力； 海外出口增长不及预期。公司持续推进白蛋白紫杉醇等制剂国际化布局，若海外注册审批、市场准入、客户拓展、订单交付或国际贸易环境变化导致出口放量低于预期，将影响海外业务收入增长及国际化战略推进； 创新管线研发及对外授权不及预期。公司积极布局GB18等创新生物药管线，若临床研发、注册审批、BD授权合作或后续商业化进展低于预期，相关产品价值兑现节奏可能受到影响，并对公司长期成长性产生一定影响。 附：盈利预测表 团队介绍 吴明华 首席分析师。厦门大学硕士，历任上市公司区域负责人、长城证券医药行业首席分析师，拥有交叉领域工作经验，2025年每市菁英镑医药生物行业第3名，2025年三季度每市菁英榜医药生物行业第1名，2024年四季度每市菁英榜医药生物行业第3名，2022年金牛分析师医药组第3名。证书编号：S0550525110002 薛路熹 医药分析师。本硕博毕业于复旦大学。本科期间开始进行基础研究，具备临床轮转经验，获临床医学博士学位，通过CPA会计、财管等四门专业阶段考试，兼具医药专业积淀与财务分析素养。 主要研究方向：创新药 隋栋庭 医药研究员，四川大学生物科学学士，香港中文大学（深圳）会计学硕士。 主要研究方向：创新药及创新产业链 刘震宇 医药研究员。南开大学生物学本科，清华大学生物学博士，师从中科院院士。在生命科学领域发表多篇顶刊论文，具备2年产业工作经历，在早期研发、项目孵化及BD（商务拓展）领域积累了较多经验。 主要研究方向：创新药 重要声明 证券研究报告 《科兴制药(688136)：三十载制药积淀，创新出海迈入收获期》 对外发布时间 2026年6月30日 报告发布机构 东北证券股份有限公司(已获中国证监会许可的证券投资咨询业务资格) 本报告分析师 吴明华S0550525110002 研究员承诺 本人具有中国证券业协会授予的证券投资咨询执业资格或相当的专业胜任能力，在执业过程中恪守独立诚信、勤勉尽职、谨慎客观、公平公正的原则，独立、客观地出具本报告。本报告反映了本人的研究观点，不曾因，不因，也将不会因本报告中的具体推荐意见或观点而直接或间接接收到任何形式的报酬。 特别声明 《证券期货投资者适当性管理办法》、《证券经营机构投资者适当性管理实施指引（试行）》已于2017年7月1日 起正式实施。因本研究报告涉及股票相关内容，仅面向东北证券客户中的专业投资者及风险承受能力为稳健型、积极型、激进型的普通投资者。若您并非上述类型的投资者，请取消阅读，请勿收藏、接收或使用本研究报告中的任何信息。 因此受限于访问权限的设置，若给您造成不便，烦请见谅！感谢您给予的理解与配合。 免责声明 东北证券股份有限公司（以下简称东北证券）具备中国证监会批准的证券投资咨询业务资格。 本报告由东北证券向专业投资者客户及风险承受能力为稳健型、积极型、激进型的普通投资者客户（以下统称客户）提供，除非另有说明，所有本报告的版权属于东北证券。未经东北证券事先书面授权许可，任何机构和个人不得以任何形式翻版、复制和发布，亦不得作为诉讼、仲裁、传媒及任何单位或个人引用的证明或依据，不得用于未经允许的其它任何用途。如引用、刊发，需注明出处为东北证券研究院，且不得对本报告进行有悖原意的引用、删节和修改。 本报告是基于本公司认为可靠的已公开信息，但本公司不保证信息的准确性或完整性。本报告所载的资料、工具、意见及推测只提供给客户作参考之用，并非作为或被视为出售或购买证券或其他投资标的的邀请或向他人作出邀请。在任何情况下，本报告中的信息或所表述的意见并不构成对任何人的投资建议。在任何情况下，本公司不对任何人因使用本报告中的任何内容所引致的任何损失负任何责任。 东北证券在法律允许的情况下可参与、投资或持有本报告涉及的证券或进行证券交易，或向本报告涉及的公司提供或争取提供包括投资银行业务在内的服务或业务支持。东北证券可能与本报告涉及的公司之间存在业务关系，并无需事先或在获得业务关系后通知客户。 东北证券版权所有并保留一切权利。

BMC Medicine [Jour] AND 24[volume] AND 1[issue]（first half of the year） 生物医学中心 - 医学 24卷 1期（上半年） https://link.springer.com/journal/12916/volumes-and-issues/24-1 369 articles in this issue Impact of a real-time automatic quality control system for magnetically controlled capsule gastroscopy: a multicenter randomized controlled trial 磁控胶囊胃镜实时自动质量控制系统的效果：一项多中心随机对照试验 Xiaoya WangDawei ShenZhen Li Research 02 May 2026 Article: 369 Lipid levels and risk-stratified management gaps of dyslipidemia in China 中国血脂水平及血脂异常风险分层管理差距 Long ZhangXu LiuJianping Li Research 02 May 2026 Article: 368 Medicine price and affordability in China and selected ASEAN countries: a cross-country comparison with forward-looking implications for regional pooled procurement 中国与部分东盟国家的药品价格和可负担性：对区域集中采购前瞻性影响的跨国比较 Zhuangqi LiShuting ZhangBao Liu Research 02 May 2026 Article: 367 Dementia risk by metabolic health and obesity in two prospective cohorts 两项前瞻性队列研究中代谢健康和肥胖对痴呆风险的影响 Martin NakashElsa Ojalehto LindforsIda K. Karlsson Research 19 June 2026 Article: 366 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Maternal B-vitamin status modifies the risk of congenital heart disease in offspring associated with prenatal persistent organic pollutants exposure 母体B族维生素状况会改变胎儿在宫内持续暴露于有机污染物时先天性心脏病的患病风险 Sainan LiHai LinLinlin Wang Research 04 May 2026 Article: 365 Obesity-derived metabolites modulate anti-tumor immunity in the tumor microenvironment: from mechanisms to clinical applications 肥胖衍生的代谢产物在肿瘤微环境中调节抗肿瘤免疫：从机制到临床应用 Yihang CaiJunyi JinXiaoying Li Review 06 May 2026 Article: 364 Part of 1 collection:Tumor microenvironment in cancer therapy 所属专题合集：癌症治疗中的肿瘤微环境 Rational use of expensive medicines in the Netherlands: strategies to improve effectiveness and reduce burden on patients and society – a narrative review 荷兰高价药品的合理使用：提高疗效、减轻患者和社会负担的策略——一项叙述性综述 Bart M.F. PenninxSander W. TasCarla E.M. Hollak Review 30 April 2026 Article: 363 NMR-based serum metabolite and lipoprotein profiling for endometriosis across clinically relevant and physiological comparator settings: assessment of diagnostic utility and exploratory biological signals 基于核磁共振（NMR）的血清代谢物和脂蛋白谱分析在子宫内膜异位症的临床相关和生理对照情况中的应用：诊断效用的评估和探索性生物信号的发现 Sisi DengAndré KochChristoph Trautwein Research 17 June 2026 Article: 362 Changes in olfactory function in children and adolescents with obesity following an inpatient weight loss program: a longitudinal study 住院减肥计划后肥胖儿童和青少年嗅觉功能的变化：一项纵向研究 Bea KlosHelene SauerIsabelle Mack Research 17 June 2026 Article: 361 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减肥干预及其对健康的影响 The neuroimmune axis in breast cancer: from mechanistic insights to clinical applications 乳腺癌中的神经免疫轴：从机制研究到临床应用 Yimao WuKaiyu ZhangMeng-Yao Li Review 30 April 2026 Article: 360 A biologically informed framework for instrument selection in dietary Mendelian randomization using chemosensory genetics 基于化学感觉遗传学的饮食孟德尔随机化工具选择生物学框架 Liang-Dar HwangCailu LinPaule V. Joseph Research 01 June 2026 Article: 359 Efficacy and safety of cyclosporine plus luspatercept versus cyclosporine in newly diagnosed non-transfusion-dependent non-severe aplastic anemia: A prospective randomized trial 环孢素联合卢帕塞普特与单用环孢素治疗新发非输血依赖型非重型再生障碍性贫血的疗效和安全性：一项前瞻性随机试验 Zhuxin ZhangQinglin HuBing Han Research 29 April 2026 Article: 358 Dietary intake and epigenetic aging in an African population: food groups, dietary patterns, and plant-based diets in the RODAM study 非洲人群的膳食摄入与表观遗传衰老：RODAM研究中的食物组、膳食模式与植物性饮食 Naomi C.S. AuwerdaMuhau. M. MungambaFelix P. Chilunga Research 28 April 2026 Article: 357 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Mitoxantrone hydrochloride liposome (Lipo-MIT) combined with capecitabine in HER2-negative advanced breast cancer: a dose-escalation, phase I study 米托蒽醌盐酸盐脂质体（Lipo-MIT）联合卡培他滨治疗HER2阴性晚期乳腺癌：一项剂量递增Ⅰ期研究 Jiaxuan LiuMingxia JiangQiao Li Research 28 April 2026 Article: 356 Familial healthy aging and longevity: the role of spouses 家族健康衰老与长寿：配偶的作用 Søren NetraAngéline GalvinKaare Christensen Research 28 April 2026 Article: 355 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Peripheral blood biomarkers RCAN1, Clusterin, RAGE, and malondialdehyde for early diagnosis and progression of Alzheimer’s disease 外周血生物标志物RCAN1、Clusterin、RAGE和丙二醛用于阿尔茨海默病的早期诊断与进展监测 Aurora Román-DomínguezCristina Mas-BarguesJosé Viña Research 27 April 2026 Article: 354 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Palliative care for the people without medical insurance in Germany: an empirical ethical approach 德国无医疗保险人群的姑息治疗：一种实证伦理方法 Matthias ZimmerAntonia Sahm Research 11 June 2026 Article: 353 Part of 1 collection:Palliative care and medicine 所属专题合集：姑息治疗与姑息医学 Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study 妊娠期母体因素与微生物衍生的细胞外囊泡特征的相关性：一项临床队列研究 Jenni TurunenKaisu KyröTerhi Ruuska-Loewald Research 28 May 2026 Article: 352 Prenatal computed tomography (CT) and risk of congenital heart disease and cerebral palsy: A nationwide mother–child paired cohort study 产前计算机断层扫描（CT）与先天性心脏病及脑瘫风险：一项全国性母子配对队列研究 Tae Wook KangJihye HeoDanbee Kang Research 27 April 2026 Article: 351 Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease 治疗性TG2抑制可逆转乳糜泻的系统性多组学失调 Valeriia DotsenkoHana Hien Leon behalf of the CEC-3 Investigators Research 24 April 2026 Article: 350 Adulthood stressful life events as predictors of incident cardiovascular disease: insights from two prospective cohorts 成年期应激性生活事件作为心血管疾病新发预测因子：来自两项前瞻性队列的见解 Shuang WuSiqi LyuGregory Y. H. Lip Research 24 April 2026 Article: 349 Camrelizumab plus apatinib for immune checkpoint inhibitor-naive patients with metastatic clear cell renal cell carcinoma after first-line tyrosine kinase inhibitor treatment failure: a single-arm phase 2 trial 卡瑞利珠单抗联合阿帕替尼用于免疫检查点抑制剂初治转移性透明细胞肾细胞癌一线酪氨酸激酶抑制剂治疗失败后：一项单臂Ⅱ期试验 Xiuyu CaiXia ZhengPei Dong Research 24 April 2026 Article: 348 Introducing the need for a consensus-based framework for protocol modifications to improve trial trustworthiness 提出建立基于共识的方案修改框架以提升临床试验可信度的必要性 Cora BurgwinkelManon GicquelClara Locher Debate 24 April 2026 Article: 347 Modelling the epidemic dynamics of HPV among women in China and optimization of ongoing cervical cancer elimination strategies 中国女性人群HPV流行动力学建模及宫颈癌消除策略优化 Yuwei LiYi-Fan LinJianxin Zhen Research 22 April 2026 Article: 346 Multiparameter concept-based interpretable model for early breast cancer diagnosis and structured reporting: a multi-center, multi-reader, radiologist-in-the-loop study 基于多参数概念的可解释模型用于早期乳腺癌诊断与结构化报告：一项多中心、多读者、放射科医师参与的研究 Jiao QuYang LiuSu Lui Research 23 April 2026 Article: 345 Blood-based DNA methylation marker model for short-term and long-term lung cancer risk prediction 基于血液DNA甲基化标志物模型的肺癌短期与长期风险预测 Megha BhardwajYi-Qian SunHermann Brenner Research 06 June 2026 Article: 344 Integrated serum proteomic and liver genomic analyses identify molecular signatures associated with metabolic dysfunction-associated steatotic liver disease: a multi-cohort study 整合血清蛋白质组学与肝脏基因组学分析鉴定与代谢功能障碍相关脂肪性肝病相关的分子特征：一项多队列研究 Jinjian XuWanglong GouYu-ming Chen Research 17 April 2026 Article: 343 Predicting amyotrophic lateral sclerosis stage based on multi-parameter ultrasound: development and validation of an interpretable machine learning model 基于多参数超声预测肌萎缩侧索硬化症分期：可解释机器学习模型的构建与验证 Tianhua YangYing WangGaoyi Yang Research 22 April 2026 Article: 342 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与更新 Duration of anti-seizure medicines started for acute symptomatic seizures due to acute meningitis: a systematic review and meta-analysis 急性脑膜炎所致急性症状性发作的抗癫痫药物起始疗程：一项系统综述与荟萃分析 Manya PrasadAmit KumarTarun Dua Research 22 April 2026 Article: 341 Part of 1 collection:Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述集 Prenatal exposure to flood and risk of low birth weight: a multi-country study from 36 African countries 产前遭遇洪水与低出生体重风险：来自36个非洲国家的多国研究 Qian LiQian LiFengchao Liang Research 21 April 2026 Article: 340 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Sunshine duration and episodes of mental disorders and the inverse effect modification by ambient temperature 日照时长与精神障碍发作及环境温度的逆效应修饰 Lijun BaiJuan ChenShaowei Wu Research 21 April 2026 Article: 339 The role of continuous glucose monitoring for diagnosis of gestational diabetes: exploring the potential 持续葡萄糖监测在妊娠糖尿病诊断中的作用：潜力探索 M. CrowleyC. NewmanF. P. Dunne Review 21 April 2026 Article: 338 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠糖尿病的诊断与治疗 Pre-diagnostic biomarkers and risk of stress-related disorders: a cohort study based on electronic health records 应激相关障碍诊断前生物标志物与风险：一项基于电子健康记录的队列 Anna A. PeltolaEsha KhanJake Lin Research 01 June 2026 Article: 337 Epigenome-wide analysis of DNA-methylation signatures following climate-related disasters 气候相关灾害后DNA甲基化信号的全表观基因组分析 Wenzhong HuangRongbin XuYuming Guo Research 20 April 2026 Article: 336 Part of 1 collection:Climate change and human health 所属专题合集：其后变化与人类健康 Redeemed prescription medicines to measure quality of life of patients with long-term conditions: a national cross-sectional study 通过已兑换的处方药衡量慢性病患者生活质量：一项全国性横断面研究 Henrik Hedegaard Pliess LarsenVolkert SiersmaAnne Holm Research 20 April 2026 Article: 335 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 属于专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Viral shedding dynamics in coxsackievirus A6 hand, foot, and mouth disease: a prospective, individual-level analysis 柯萨奇病毒A6型手足口病的病毒排毒动态：一项前瞻性个体水平分析 Jiale MengYue ChengLu Long Research 18 April 2026 Article: 334 Mental health and wellbeing interventions for uniformed service personnel: a mixed methods systematic review 军警人员心理健康与福祉干预措施：一项混合方法系统综述 Jessica EatonHolly EllardAlan Simpson Research 17 April 2026 Article: 333 WISE-Therapy (What’s Important: Schedule and Engage) and bouldering psychotherapy for depression: A randomized clinical trial WISE-Therapy（智慧疗法）（重要之事：安排与参与）与抱石心理治疗用于抑郁症：一项随机临床试验 Johannes KornhuberPiotr LewczukKatharina Luttenberger Research 27 May 2026 Article: 332 Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention 握力减弱与类风湿关节炎患者运动皮层萎缩相关：一项包含手部运动干预的横断面研究 Amanda L GustafssonRolf A HeckemannCaroline Wasén Research 26 May 2026 Article: 331 Interpretable multimodal PET/CT-EHR fusion via mixture-of-experts for prognostic stratification in mantle cell lymphoma: a multicenter study 基于专家混合模型的可解释性多模态PET/CT-HER（电子健康记录）融合在套细胞淋巴瘤预后分层中的应用：一项多中心研究 Chong JiangZitong ZhangRong Tian Research 16 April 2026 Article: 330 Non-invasive diagnosis strategy integrating PSMA PET/CT and mpMRI for patients with suspected prostate cancer: a multi-center study 整合PSMA PET/CT与多参数MRI的无创诊断策略用于疑似前列腺癌患者：一项多中心研究 Yuhang WangYongxiang TangYi Cai Research 16 April 2026 Article: 329 Clinical benefit of tenecteplase despite failed recanalization in late-window ischemic stroke: a post hoc analysis of the TRACE-3 trial 晚期窗口缺血性卒中中即使再通失败，替奈普酶仍具临床获益：TRACE-3试验的事后分析 Zhengzhao LuZiran WangYongjun Wang Research 16 April 2026 Article: 328 Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study 婴儿皮层下脑容量与母亲肥胖及糖尿病相关：一项大型多队列人类研究 Ann M. AlexJerod M. RasmussenENIGMA-ORIGINs working group Research 16 April 2026 Article: 327 Cost-effectiveness of prehabilitation for elderly (pre-)frail patients prior to elective surgery compared to standard care - an economic evaluation from a societal perspective 择期手术前老年（衰弱前期/）衰弱患者预康复与标准护理的成本效益比较——一项基于社会视角的经济学评估 Tanja RombeyHelene EckhardtLukas Schöner Research 21 May 2026 Article: 326 Frozen melanoma tissues yield extracellular vesicles with preserved diagnostic and immunogenic properties 冷冻黑色素瘤组织可获得具有保存完好的诊断和免疫特性的细胞外囊泡 Daniele D´ArrigoKyong-Su ParkRossella Crescitelli Research 21 May 2026 Article: 325 Mechanisms underlying immunodynamics of layered defenses elicited by mRNA vaccination in children 儿童mRNA疫苗接种所引发的分层防御免疫动力学的潜在机制 Yiyu LiaoHoong Kai ChuaKeisuke Ejima Research 15 April 2026 Article: 324 Epigenetic aging markers in the association between frailty and mortality among U.S. adults 美国成年人虚弱与死亡率相关性中的表观遗传衰老标志物 May A. BeydounNicole Noren HootenAlan B. Zonderman Research 15 April 2026 Article: 323 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Evolution with age of the relationship between sex and post-COVID symptoms: a population-based cohort study 性别与新冠后遗症症状关系随年龄的演变：一项基于人群的队列研究 Anne PastorelloCécile Vuillermozfor the EpiCov study group Research 14 April 2026 Article: 322 Bowel cancer care in individuals with an intellectual disability: a population-based cohort study of symptoms, diagnostic pathways, treatment and survival 智力障碍个体的肠癌护理：症状、诊断路径、治疗及生存的基于人群的队列研究 Oliver John KennedyUmesh ChauhanDarren Mark Ashcroft Research 20 May 2026 Article: 321 Association of antiviral use for influenza among non-severe cases with subsequent hospitalization and mortality 非重症流感病例使用抗病毒药物与后续住院及死亡的关系 Taito KitanoShinya TsuzukiSayaka Yoshida Research 06 April 2026 Article: 320 Social and digital engagement associated with reduced depressive symptoms in adults aged 50 and older: a multi-country cohort study 社交及数字互动与50岁及以上成年人抑郁症状减少的关系：一项多国队列研究 Yaping WangLiyuan TaoJue Liu Research 07 April 2026 Article: 319 Fat-soluble vitamin deficiency in children with neurodevelopmental disorders: a cross-sectional study 神经发育障碍儿童脂溶性维生素缺乏：一项横断面研究 Jingjing RaoXiaomei WangChangzhen Li Research 08 April 2026 Article: 318 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA) 巴尔的摩老龄化纵向研究（BLSA）中骨骼肌与心肌的纵向关联 Jie Jun WongFei GaoAngela S. Koh Research 06 April 2026 Article: 317 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study 早期重复经颅磁刺激预防老年患者慢性术后疼痛：一项随机临床子研究 Wei-Wei ZhouZhi YangChao-Chao Zhong Research 06 April 2026 Article: 316 Part of 1 collection:Neuromodulation in brain functional disorders 所属专题合集：脑功能障碍中的神经调控 Clinical epidemiology and risk prediction of unsuccessful treatment outcomes in pulmonary tuberculosis with diabetes mellitus 合并糖尿病的肺结核治疗失败结局的临床流行病学与风险预测 Ping LiFeilong LuJunjun Jiang Research 25 March 2026 Article: 315 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Spatiotemporal patterns of climate-sensitive vector-borne diseases in Bangladesh: leveraging machine learning and spatial regression for intervention strategies 孟加拉国气候敏感型虫媒传染病的时空格局：利用机器学习与空间回归制定干预策略 Md. Siddikur RahmanMd. Abu Bokkor ShiddikArman Hossain Chowdhury Research 13 April 2026 Article: 314 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 The association of pregnancy complications/risk factors with the development of cancer in women: an umbrella review 妊娠并发症/危险因素与女性癌症发生的关系：一项伞状综述 Jemma HealeyMegha SinghMairead Black Research 13 April 2026 Article: 313 Synergistic effects of obesity and type 2 diabetes on adiposity-related cancer risk across age strata 肥胖与2型糖尿病对不同年龄层肥胖相关癌症风险的协同效应 Alex E. HenneyMegan HeagueDaniel J. Cuthbertson Research 13 April 2026 Article: 312 Acute COVID-19 severity and impaired cognitive function up to 32months after diagnosis: an observational study 急性新冠严重程度与确诊后长达32个月的认知功能损害：一项观察性研究 Ingibjörg MagnúsdóttirAnders B. NygaardUnnur Anna Valdimarsdóttir Research 11 April 2026 Article: 311 Maternal macronutrient intake and gestational diabetes: systematic review of prospective observational studies and dose-response meta-analyses 孕产妇宏量营养素摄入与妊娠期糖尿病：前瞻性观察研究的系统综述及剂量反应荟萃分析 Cameron D. YoungMichael G. GarrattAndrew N. Reynolds Research 11 April 2026 Article: 310 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠期糖尿病的诊断与管理 Global, regional, and national burden of colorectal cancer attributable to central obesity: a population attributable fraction analysis 中心性肥胖所致结直肠癌的全球、区域及国家负担：人群归因分数分析 Daniele PiovaniGisella FiglioliStefanos Bonovas Research 10 April 2026 Article: 309 Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study 评估首段尿液中DNA甲基化标志物及扩展型HPV基因分型在HPV阳性女性中检测高级别宫颈病变的价值：一项横断面研究 Mette TranbergSeverien Van KeerRenske Steenbergen Research 10 April 2026 Article: 308 Targeted long-read genomic and epigenomic profiling enhances timely comprehensive variant discovery in hypotonia and muscle weakness 靶向长读长基因组与表观基因组测序提升低张力与肌无力的全面变异及时发现 Eman AbuijlanShruti SinhaAhmad Abou Tayoun Research 08 April 2026 Article: 307 Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions 靶向肺疾病中的免疫衰老：机制洞察与临床干预 Yin ZhangXianzhe YuFengming Luo Review 08 April 2026 Article: 306 Apolipoprotein C3 drives adverse cardiac remodeling in ischemic heart failure 载脂蛋白C3促进缺血性心力衰竭中的不良心脏重塑 Yufei HanYixue ZhaoXunde Xian Research 09 April 2026 Article: 305 Part of 1 collection:Cardiac immunity and inflammation 所属专题合集：心脏免疫与炎症 Causal modeling of school aversion in psychiatrically referred adolescents: a DoWhy-based analysis 转诊精神病科的青少年厌学情绪的因果模型：基于DoWhy的分析 Mengmeng ZhangXin MaMeijuan Wang Research 09 April 2026 Article: 304 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Aperiodic and periodic neural activity during sleep in autism spectrum disorders 自闭症谱系障碍睡眠中的非周期性和周期性神经活动 Noemi MazzoniEva-Maria KurzAndrea Caria Research 18 March 2026 Article: 303 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Association and mediating pathways between intergenerational educational mobility and depressive symptoms: findings from high- and middle-income countries 代际教育流动性与抑郁症状之间的关联及中介路径：来自高收入和中等收入国家的发现 Yingchao ZengSimu HuangChihua Li Research 02 April 2026 Article: 302 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Scoping review on the prioritisation of high-consequence infectious pathogens for research preparedness and response to health emergencies 关于优先研究高后果性感染病原体以应对突发卫生事件的研究准备与响应的范围综述 Nicolas PulikHolly SadlerAlice Norton Research 01 April 2026 Article: 301 Serum uric acid levels among children and adolescents in China: percentile reference values and national prevalence estimates of hyperuricemia 中国儿童和青少年血清尿酸水平：高尿酸血症的百分位参考值和全国患病率估计 Qianrang ZhuXin’nan ZongMin Zhao Research 31 March 2026 Article: 300 Waist circumference and grip strength and their joint relations to type 2 diabetes incidence in UK Biobank 腰围和握力及其与英国生物银行中2型糖尿病发病风险的联合关系 Johanna WirlerMichael J. SteinMichael F. Leitzmann Research 07 May 2026 Article: 299 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Targeting cardiomyocyte-derived extracellular vesicle miR-574-5p protects against cognitive impairment induced by ischemia–reperfusion 靶向心肌细胞衍生的外泌体miR-574-5p可预防缺血再灌注引起的认知障碍 Erya ChenXiaoyu ZhuChan Chen Research 19 March 2026 Article: 298 Motor-related reorganization in left inferior frontal gyrus after subcortical stroke: neurochemical basis and response to targeted neuromodulation 皮层下卒中后左侧额下回的运动相关重组：神经化学基础及靶向神经调控的反应 Wenjun HongYaxi WangZhiyong Zhao Research 27 March 2026 Article: 297 Part of 1 collection:Neuromodulation in brain functional disorders 所属专题合集：脑功能疾病中的神经调控 Association between ambient temperature and childhood vaccination coverage in low- and middle-income countries 中低收入国家环境温度与儿童疫苗接种覆盖率之间的关联 Hongqiu ZhengYixiang ZhuZhiyuan Hou Research 11 March 2026 Article: 296 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss 肌萎缩侧索硬化症奖赏回路白质改变：基于纤维束的食欲减退研究 Jeryn ChangHarry LipscombeThomas B. Shaw Research 27 March 2026 Article: 295 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 The adverse effects associated with tirzepatide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis 替西帕肽在心血管事件风险增加患者中的不良反应：一项系统综述与荟萃分析及试验序贯分析 Christina Dam Bjerregaard SillassenPascal FaltermeierJanus Christian Jakobsen Research 27 March 2026 Article: 294 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减肥干预措施及其健康影响 Age-related genomic characterization and therapeutic targets in Chinese breast cancer: insights from prospective targeted sequencing and clinical data analysis 中国乳腺癌年龄相关基因组特征及治疗靶点：前瞻性靶向测序与临床数据分析的见解 Xin-Yi SuiXiao-Qing SongLei Fan Research 27 March 2026 Article: 293 Impact of the family cohesion-centered frailty intervention on older gastric cancer patients: a non-randomized controlled trial 以家庭凝聚力为中心的衰弱干预对老年胃癌患者的影响：一项非随机对照试验 Yinning GuoYimeng ChenQin Xu Research 27 March 2026 Article: 292 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症临床试验 Perceptions of HPV vaccination: a qualitative study with adolescents, parents, school staff, and pharmacists 对HPV疫苗接种的看法：一项针对青少年、家长、学校工作人员和药剂师的定性研究 Laurène HoutinLucia RomoClémence Brun Research 26 March 2026 Article: 291 Risk classification of internet gaming disorder based on neurobiological subtyping from impulsivity-linked resting-state functional connectivity: a longitudinal design study 基于冲动性相关静息态功能连接神经生物学亚型的网络游戏障碍风险分类：一项纵向设计研究 Xinwen WenJiahao ZhaoKai Yuan Research 26 March 2026 Article: 290 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Trainee-delivered school-based intervention with guided narrative writing for adolescent anxiety and depression: a cluster randomized controlled trial 由受训者实施的、基于学校的、以引导性叙事写作为干预手段的青少年焦虑和抑郁干预：一项整群随机对照试验 Yixuan WangMuyang LiYinyin Zang Research 26 March 2026 Article: 289 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Nourishing future generations: the critical role of healthy school lunches and strategic food procurement 滋养未来一代：健康学校午餐和战略性食品采购的关键作用 Aurora Perez-CornagoCarmen Piernas Comment 05 May 2026 Article: 288 Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury 多组学分析揭示人类骨骼肌损伤后肌无力的性别特异性病因 Alexander R. KeebleAllison M. OwenChristopher S. Fry Research 26 March 2026 Article: 287 Public health impact of catch-up vaccination or additional booster doses with pre-erythrocytic malaria vaccine R21/Matrix-M: a modelling study 使用红细胞前期疟疾疫苗R21/Matrix-M进行追赶接种或额外加强接种的公共卫生影响：一项建模研究 Kelly McCainHillary M. TopazianAzra C. Ghani Research 25 March 2026 Article: 286 A digital-health multidomain lifestyle management framework and its associations with cardiometabolic health: a real-world observational study 数字健康多领域生活方式管理框架及其与心脏代谢健康的关联：一项现实观察性研究 Han XiaoKexin DingDafang Chen Research 25 March 2026 Article: 285 Bilateral sequential accelerated theta-burst stimulation for treatment-resistant depression: an open-label randomized controlled trial 双侧序贯加速θ波爆发刺激治疗难治性抑郁症：一项开放标签随机对照试验 Xingxing LiEnze TangDongsheng Zhou Research 25 March 2026 Article: 284 Part of 1 collection:Neuromodulation in brain functional disorders 所属专题合集：脑功能疾病中的神经调控 Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders SPG7和AFG3L2基因突变双基因遗传导致运动神经元和小脑疾病 Mehrdad A. EstiarEric YuZiv Gan-Or Research 24 March 2026 Article: 283 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新颖动态 Social isolation and 59 common health conditions: insights from observational and genetics analyses 社交孤立与59种常见健康状况：观察性研究与遗传学分析的见解 Sizhi AiQiqi WuYannis Yan Liang Research 23 March 2026 Article: 282 Clustering depression subgroups based on dorsolateral prefrontal-subgenual anterior cingulate cortex peak functional connectivity reveals different symptom profiles and TMS treatment outcomes 基于背外侧前额叶-膝下前扣带回皮层峰值功能连接性的抑郁亚组聚类分析揭示了不同的症状特征和经颅磁刺激（TMS）治疗结果 Gai KongSirui WangYingying Tang Research 23 March 2026 Article: 281 Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours 人类遗传学有力证据支持成纤维细胞生长因子21（FGF21）对减少饮酒行为的因果效应 Héléne T. CronjéSile HuDipender Gill Research 23 March 2026 Article: 280 Artificial intelligence-based prediction of fetal hypoxia: a multicenter model development and nationwide AI-human comparison 基于人工智能的胎儿缺氧预测：多中心模型开发及全国范围的人工智能与人类对比 Suiwen LinXiaodan DiBin Liu Research 21 March 2026 Article: 279 Efficacy and long-term engagement of a WeChat-integrated modality versus a traditional quitline on smoking cessation in China: a randomised controlled trial 微信整合模式与传统戒烟热线在中国戒烟中的疗效及长期参与度：一项随机对照试验 Shuilian ChuDi ZhangLirong Liang Research 21 March 2026 Article: 278 A culturally-safe primary care intervention for migrant/refugee women suffering domestic violence and abuse: HARMONY—a pragmatic cluster randomised controlled trial 针对遭受家庭暴力和虐待的移民/难民妇女的文化安全初级护理干预措施：HARMONY——一项实用性整群随机对照试验 Angela J. TaftFelicity YoungGene Feder Research 21 March 2026 Article: 277 Development, integration, retention, and career progression of physician associates/assistants in UK NHS hospitals and clinical teams: a multiple-case qualitative study 英国国家医疗服务体系（NHS）医院及临床团队中医师助理/协理医师的发展、整合、留任及职业晋升：一项多案例定性研究 Yingxi ZhaoRhys SwainstonThe ROADMAP-PA collaborator group Research 20 April 2026 Article: 276 Compound climate extreme events and associated health impacts: a scoping review 复合气候极端事件及其相关健康影响：一项范围性综述 Shifali MathewsCaitlin WalkerJaime Madrigano Research 20 March 2026 Article: 275 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Smoking history, eligibility for lung cancer screening and risk of death by lung cancer or other causes -- a longitudinal, time-variable analysis of the EPIC-Heidelberg cohort 吸烟史、肺癌筛查资格以及死于肺癌或其他原因的风险——对EPIC-海德堡队列的纵向、时变分析 Yue ChenSrimanti DuttaRudolf Kaaks Research 28 April 2026 Article: 274 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Cortical functional hierarchy disruption following subcortical stroke 皮质功能层级在皮层下卒中后的破坏 Ke WuGang LiuGaolang Gong Research 19 March 2026 Article: 273 Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization 利用孟德尔随机化方法表征遗传易感性对自身免疫性疾病患者妊娠结局的影响 Elisabeth AitonNancy S. McBrideMaria Carolina Borges Research 19 March 2026 Article: 272 Dystrophin-gene mutation location influences severity of electroretinogram defects in mouse models of Duchenne muscular dystrophy 杜氏肌营养不良症小鼠模型中，肌营养不良蛋白基因突变位置对视网膜电图缺陷严重程度的影响 André Maurício Passos LiberMirella BarboniCyrille Vaillend Research 25 April 2026 Article: 271 Personalizing the treatment of head and neck cancer in vitro: The 3D-OTC model 体外个性化治疗头颈部肿瘤：三维器官芯片（3D-OTC）模型 Fabian StögbauerTobias WeiserBarbara Wollenberg Research 25 April 2026 Article: 270 Part of 1 collection:Organoids: connecting molecular insights and clinical practice 所属专题合集：类器官：连接分子见解与临床实践 Risk factor profiles for infections in individuals with type 2 diabetes: a prospective cohort study 2型糖尿病患者感染的风险因素特征：一项前瞻性队列研究 Han-Cheng YuJi-Juan ZhangYun-Fei Liao Research 18 March 2026 Article: 269 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Cause-specific years of life lost attributable to non-optimal body mass index by county, sex, race, and ethnicity in the USA, 2000–2019: a systematic analysis of health disparities 2000-2019年美国按县、性别、种族和民族划分的非最佳体重指数导致的特定原因寿命损失年数：一项关于健康差异的系统分析 GBD US Health Disparities CollaboratorsFarah MouhannaLaura Dwyer-Lindgren Research 18 March 2026 Article: 268 Global and regional prevalence, burden, and risk factors for MASLD in children and adolescents aged 5 to 24years: a systematic review, meta-analysis, and modeling study 全球和区域5至24岁儿童和青少年代谢相关脂肪性肝病（MASLD）的患病率、负担及风险因素：一项系统综述、荟萃分析和建模研究 Yunfei LiuShan CaiSusan M. Sawyer Research 18 March 2026 Article: 267 Relative leukocyte telomere length and the risk of lung cancer progression in individuals with pulmonary nodules 相对白细胞端粒长度与肺结节患者肺癌进展风险的关系 Yuanyuan WuDong SunFeifei Cheng Research 18 March 2026 Article: 266 Effects of Tai Chi combined with transcranial direct current stimulation on pain in knee osteoarthritis: a randomized controlled neuroimaging trial 太极拳结合经颅直流电刺激对膝骨关节炎疼痛的影响：一项随机对照神经影像学试验 Xuefeng LiuTong TangJing Tao Research 17 March 2026 Article: 265 DNA hypermethylation of choline kinases drives blockage of choline-phosphatidylcholine biosynthesis: lipidomic biomarkers and epigenetic insights of hepatic steatosis induced by arsenic 胆碱激酶DNA高甲基化驱动胆碱-磷脂酰胆碱生物合成受阻：砷诱导的肝脂肪变性的脂质组学生物标志物及表观遗传学见解 Qiwen FuQi WangLu Ma Research 17 March 2026 Article: 264 Dynamics of Mpox epidemics by the interplay of COVID-19 pandemic in Africa 非洲猴痘（Mpox）流行与新冠肺炎（COVID-19）大流行相互作用下的猴痘流行病学动态 Oyewole K. OyedeleNifarta P. AndrewAlash’le Abimiku Research 17 March 2026 Article: 263 Part of 1 collection:Mpox: Epidemiology, prevention, and treatment 所属专题合集：猴痘：流行病学、预防和治疗 SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection SPP1高表达成纤维性巨噬细胞介导保护性纤维化重塑并促进高血压相关主动脉夹层的血管稳定性 Shuai ZhaoXiumeng HuaJiangping Song Research 16 March 2026 Article: 262 Longitudinal associations between body fat mass and cardiovascular outcomes among Chinese children: mediation by cardiometabolic risk factors 中国儿童身体脂肪量与心血管结局之间的纵向关联：通过心脏代谢风险因素的中介作用 Hui YangQin LiuBo Xi Research 16 March 2026 Article: 261 The timing of the commencement of pulmonary rehabilitation in hospitalized patients with acute exacerbation of COPD: a systematic review and network meta-analysis 住院慢性阻塞性肺疾病急性加重患者开始肺康复治疗的时机：一项系统综述和网络荟萃分析 Peilin JiaHailong ZhangLongyu Wang Research 16 March 2026 Article: 260 Correction: Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study 更正：膀胱癌流行病学和营养决定因素（BLEND）国际研究中蔬菜摄入量与膀胱癌风险的关系 Evan Yi-Wen YuAnke WesseliusMaurice P. Zeegers Correction 22 April 2026 Article: 259 Comparative efficacy of neoadjuvant short-course versus long-course radiotherapy-based regimens with or without immunotherapy for locally advanced pMMR rectal cancer: a systematic review and network meta-analysis 基于放疗的新辅助短疗程与长疗程治疗方案（联合或不联合免疫治疗）对局部晚期错配修复功能正常（pMMR）型直肠癌的疗效比较：一项系统综述与网状荟萃分析 Liqing LiXiaoyao MengTingshi Su Research 14 March 2026 Article: 258 Association between bariatric surgery and long-term ability to perform household tasks in the Swedish Obese Subjects study: a controlled prospective cohort study 瑞典肥胖受试者研究：减肥手术与长期从事家务能力之间的关联——一项对照前瞻性队列研究 Petra BrembeckJohanna C. Andersson-AssarssonPer-Arne Svensson Research 18 April 2026 Article: 257 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减重干预措施及其健康影响 The role of male foetal sex on maternal and neonatal outcomes in pregnancies complicated by gestational diabetes—secondary analysis of a randomised placebo controlled clinical trial of metformin in gestational diabetes (EMERGE) 男性胎儿性别对妊娠期糖尿病合并妊娠的母婴预后的影响——妊娠期糖尿病二甲双胍随机对照安慰剂临床试验（EMERGE）的二次分析 Christine NewmanAlberto Alvarez-IglesiasFidelma Dunne Research 12 March 2026 Article: 256 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠期糖尿病的诊断与管理 Downregulated lysyl oxidase in plasma extracellular vesicles: a biomarker linked to brain metastasis risk in lung adenocarcinoma 血浆细胞外囊泡中赖氨酰氧化酶表达下调：与肺腺癌脑转移风险相关的生物标志物 Jing LiYu PeiYi Liu Research 12 March 2026 Article: 255 The influence of age-dependent susceptibility on RSV transmission dynamics and immunisation population-level impact 年龄依赖性易感性对呼吸道合胞病毒（RSV）传播动力学及免疫接种人群层面影响的研究 Chenkai ZhaoYuhe ZhangHarish Nair Research 11 March 2026 Article: 254 A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress 一株人源拟杆菌属菌株可减轻社会挫败诱导应激大鼠模型的抑郁样行为 Marisol I. DothardMariaelena CaboniPhilip Strandwitz Research 10 March 2026 Article: 253 Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing 童年和成年期的不良事件均与衰老的分子、临床和功能标志物相关 Monica AasThole H HoppenJulian Mutz Research 28 April 2026 Article: 252 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Genetic predisposition to high BMI, ultra-processed food consumptions in childhood, and adiposity in young adulthood: a 17-year prospective cohort study of 3061 individuals 高BMI遗传易感性、儿童期超加工食品摄入与成年早期肥胖：一项对3061例个体进行的为期17年的前瞻性队列研究 Ziyi ZhouQiaosen ChenFrederick K. Ho Research 16 April 2026 Article: 251 Enhanced predictive performance of artificial intelligence in individualized ovarian stimulation of in vitro fertilization: a retrospective cohort study 人工智能在体外受精个体化卵巢刺激中的预测性能提升：一项回顾性队列研究 Guiquan WangMinyue TangYimin Zhu Research 10 March 2026 Article: 250 PCDSOS: a novel clinical predictive tool for screening primary ciliary dyskinesia in adult bronchiectasis patients—a multicenter derivation and external validation study PCDSOS：一种用于筛查成人支气管扩张症患者原发性纤毛运动障碍的新型临床预测工具——一项多中心推导及外部验证研究 Wangji ZhouLin WangXinlun Tian Research 10 March 2026 Article: 249 Detection rate and mutational landscape in extracranial arteriovenous malformations: a cohort study 颅外动静脉畸形的检出率及突变谱：一项队列研究 Vanessa F. SchmidtDenny Schanzefor the APOLLON Investigators Research 16 April 2026 Article: 248 Kinetics of antibodies and risk of respiratory syncytial virus infection: a longitudinal cohort in Taizhou City, eastern China 抗体动力学与呼吸道合胞病毒感染风险：中国东部台州市的一项纵向队列研究 Qiang WangDavid HodgsonWeibing Wang Research 09 March 2026 Article: 247 Cell therapy strategies for organ regeneration 器官再生的细胞治疗策略 L. PapamichailL. J. W. van der LaanM. J. Hoogduijn Review 25 February 2026 Article: 246 Transcutaneous spinal cord stimulation combined with robot-assisted gait training to improve mobility and balance in spinal cord injury: intramuscular electromyography as a biomarker for functional recovery 经皮脊髓电刺激联合机器人辅助步态训练改善脊髓损伤患者的行动能力和平衡能力：肌内肌电图作为功能恢复的生物标志物 Abdul RashadHe XijingMuhammad Asif Registered Report 09 March 2026 Article: 245 Neoadjuvant camrelizumab combined with radiotherapy as a chemotherapy-sparing approach for resectable locally advanced esophageal squamous cell carcinoma: a phase II clinical trial (ESOCORT-NIRT) 新辅助卡瑞利珠单抗联合放疗作为可切除局部晚期食管鳞癌的免化疗方案：一项II期临床试验（ESOCORT-NIRT） Maohui ChenYizhou HuangBin Zheng Research 09 March 2026 Article: 244 FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy FLASH放疗在保持抗肿瘤疗效的同时维持全身及组织稳态 Giulia FuriniEduarda Mota da SilvaMargherita Maffei Research 26 February 2026 Article: 243 fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial 功能磁共振成像引导的V1区靶向重复经颅磁刺激改善青少年及青年双相情感障碍患者的抑郁症状：一项双盲随机对照试验 Xudong ZhaoHetong ZhouMinmin Wang Research 07 March 2026 Article: 242 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童及青少年精神病学 Impairment of brain short association fibers across clinical stages in amyotrophic lateral sclerosis: a new biomarker mirroring disease progression 肌萎缩侧索硬化症临床各阶段脑短联结纤维受损情况：一种反映疾病进展的新型生物标志物 Nao-Xin HuangZi-Wei CaiHua-Jun Chen Research 06 March 2026 Article: 241 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Social frailty and the risk of progression from health to physical, psychological, and cognitive multimorbidity: a prospective multi-cohort study 社会脆弱性与从健康状态进展至身体、心理及认知多病共存状态的风险：一项前瞻性多队列研究 Yaguan ZhouHtet Lin HtunYi Guo Research 06 March 2026 Article: 240 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用 Association between early life constituent-specific PM2.5 exposure and child development and the moderating role of greenness: a nationwide study in China 中国全国范围内早期生命特定成分PM2.5暴露与儿童发育的关联及绿地调节作用的研究 Ruili LiXiaoguo ZhengXiaoning Lei Research 06 March 2026 Article: 239 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童及青少年精神病学 Intravenous thrombolysis versus standard medical therapy in minor stroke patients with large vessel severe stenosis or occlusion: a systematic review and meta-analysis 静脉溶栓与标准药物治疗轻型卒中合并大血管重度狭窄或闭塞患者的系统综述与荟萃分析 Tianhao ZhangLin TongZhigang Liang Research 06 March 2026 Article: 238 Long-term risk of offspring type 1 and type 2 diabetes following maternal gestational diabetes mellitus: a nationwide birth cohort study with 10-year follow-up 母亲妊娠期糖尿病后子女患1型和2型糖尿病的长期风险：一项为期10年随访的全国出生队列研究 Joon Ho MoonHan Na JungSung Hee Choi Research 06 March 2026 Article: 237 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠期糖尿病的诊断与治疗 Parental income in childhood and health outcomes across age groups: a register-based study from Norway 童年期父母收入与各年龄段健康结局：一项基于挪威登记数据的研究 Bjørn-Atle RemeHans Fredrik SundeJonathan Wörn Research 06 March 2026 Article: 236 AI-based quality control was associated with improved fetal ultrasound image quality in low-resource settings: a real-world multicenter study from West China 基于人工智能的质量控制可改善低资源环境下胎儿超声图像质量：一项来自中国西部的现实多中心研究 Jianxin ZhaoYao TangYong Huang Research 06 March 2026 Article: 235 Reply to: Intraoperative use of sodium oxybate to prevent post-operative delirium in older patients undergoing major orthopedic surgery 回复：术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄 Meiying CuiHang XuePing Zhao Matters Arising 13 April 2026 Article: 234 Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis 无假设的循环代谢组学评估为肌萎缩侧索硬化症中能量底物可用性的细胞特异性作用提供见解 Elham AlhathliJohnathan Cooper-KnockPamela J. Shaw Research 06 March 2026 Article: 233 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Intraoperative use of sodium oxybate to prevent postoperative delirium in older patients undergoing major orthopedic surgery 术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄 Fu-Shan XueDan-Feng WangXiao-Chun Zheng Matters Arising 13 April 2026 Article: 232 Statin therapy and stroke risk in patients with hypercholesterolaemia: a population-based longitudinal study using electronic health records in South London 他汀类药物治疗与高胆固醇血症患者卒中风险：一项基于南伦敦电子健康记录的纵向人群研究 Marc DelordAbdel Douiri Research 05 March 2026 Article: 231 Thermal ablation versus hepatectomy for solitary colorectal liver metastases up to 5 cm: a multicenter target trial emulation on safety, efficacy, and cost-effectiveness 热消融与肝切除术治疗直径达5厘米的孤立性结直肠癌肝转移：一项关于安全性、疗效及成本效益的多中心目标试验模拟研究 Jianming LiLu LiPing Liang Research 05 March 2026 Article: 230 Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetes 为何高胰岛素血症不利于减重：来自1型糖尿病的见解 Stephan MartinKerstin KempfHubert Kolb Debate 10 April 2026 Article: 229 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减重干预措施及其健康影响 Interventions to prevent and treat multiple long-term conditions and their consequences across the life course: concepts and definitions 预防和治疗多种长期疾病及其在生命周期中后果的干预措施：概念与定义 Miles D. WithamGuruprasad P. AithalThe Multiple Long-Term Conditions Cross-NIHR Collaboration Interventions and Prevention Workstream Forum 10 April 2026 Article: 228 Effectiveness of nirmatrelvir/ritonavir and molnupiravir on post-COVID diabetes risk among an older adult cohort: a target trial emulation study 奈玛特韦/利托那韦和莫努匹韦对老年人群新冠后糖尿病风险的影响：一项目标试验模拟研究 Zihao GuoYuchen WeiKa Chun Chong Research 17 March 2026 Article: 227 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与传染病 Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS 瑞典基于人群的队列研究AMORIS中铁缺乏与痴呆风险的证据 Mozhu DingAlexandra WennbergKarin Modig Research 08 April 2026 Article: 226 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Effects of ultrasound-guided stellate ganglion block in poststroke bulbar palsy: a double-blind placebo-controlled trial 超声引导下星状神经节阻滞对脑卒中后球麻痹的影响：一项双盲安慰剂对照试验 Hongji ZengWeihong ZhangXi Zeng Research 04 March 2026 Article: 225 Dual-utility ctDNA in diffuse large B-cell lymphoma: integrated genotyping unveils minimal residual disease dynamics and subtype-specific clonal evolution 双用途循环肿瘤DNA在弥漫性大B细胞淋巴瘤中的应用：整合基因分型揭示微小残留病灶动态变化及亚型特异性克隆演变 Jin-Hua LiangYi-Fan WuWei Xu Research 04 March 2026 Article: 224 Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2pathogenic variant carriers: a prospective cohort study BRCA1和BRCA2致病性变异携带者患非乳腺、非卵巢癌的风险：一项前瞻性队列研究 Ruotong YangRobert J. MacInnisShuai Li Research 04 March 2026 Article: 223 Cardiovascular outcomes of intensive blood pressure control in patients with and without metabolic dysfunction-associated fatty liver disease: post hoc analysis of the CRHCP trial 在伴有和不伴有代谢功能障碍相关脂肪性肝病的患者中，强化血压控制的心血管预后：CRHCP试验的事后分析 Songyue LiuYangzhi YinXiaofan Guo Research 04 March 2026 Article: 222 The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations 慢性阻塞性肺疾病和吸入性糖皮质激素在心血管-肾脏-代谢人群主要不良心血管事件中的作用 Anne E. IoannidesEmily L. GraulJennifer K. Quint Research 04 March 2026 Article: 221 Ethnic differences in the burden of cardiovascular disease risk factors among adult residents of London: the TOGETHER study 伦敦成年居民心血管疾病风险因素负担的种族差异：TOGETHER研究 Fotios BarkasMalo DirouKausik K. Ray Research 03 March 2026 Article: 220 Development of a novel prognostic assessment tool for recurrent respiratory papillomatosis 复发性呼吸道乳头瘤病新型预后评估工具的开发 Satoshi YamadaTaro IkegamiKiyoshi Misawa Research 16 April 2026 Article: 219 Response to: Matters Arising in relation to “Evaluating agreement between individual nutrition randomised controlled trials and cohort studies – a meta-epidemiological study” 针对“评估个体营养随机对照试验与队列研究之间的一致性——一项元流行病学研究”的相关问题探讨 Julia StadelmaierGina BantleLukas Schwingshackl Matters Arising 09 April 2026 Article: 218 Concordance between nutritional cohorts and randomized trials: biological confirmation or statistical consequence? A re-analysis of Stadelmaier et al. 营养队列研究与随机试验之间的一致性：生物学证实还是统计学结果？对Stadelmaier等人的研究再分析 Matthew CalkinsIsaac NúñezAdrian Soto-Mota Matters Arising 09 April 2026 Article: 217 Multimorbidity patterns and 15-year trajectories of physical performance: a population-based study 多病共存模式与15年身体机能变化轨迹：一项基于人群的研究 Francesco PalmeseDavide Liborio VetranoFederico Triolo Research 25 March 2026 Article: 216 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 The need for clinical studies assessing whether weight loss improves functional outcome after stroke in diabetes 评估减肥是否改善糖尿病患者中风后功能预后的临床研究需求 Ellen VercalsterenMichael V. MazyaCesare Patrone Debate 24 March 2026 Article: 215 Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice 靶向STE20型激酶MST3可改善小鼠代谢功能障碍相关脂肪性肝炎，且不影响肝细胞癌的发展 Jingjing ZhangXiangdong GongyeMargit Mahlapuu Research 24 March 2026 Article: 214 Multimorbidity patterns and the subsequent risk of albuminuria: findings from the Stockholm Creatinine Measurements (SCREAM) project 多病共存模式与后续白蛋白尿风险：来自斯德哥尔摩肌酐测量（SCREAM）项目的研究结果 Giorgi BeridzePatrick B. MarkJuan-Jesus Carrero Research 24 March 2026 Article: 213 Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma 胶质母细胞瘤神经元微环境中髓系来源的免疫抑制对嵌合抗原受体T细胞的影响 Junyi ZhangJasmin von EhrYahaya A. Yabo Research 13 March 2026 Article: 212 Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization 基因预测的白细胞介素-6和肿瘤坏死因子信号通路与结直肠癌患者死亡率之间的关联：一项双样本孟德尔随机化研究 Martina BoukaKatharina NimptschTobias Pischon Research 06 March 2026 Article: 211 Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS 血管生成素样系统紊乱将肌萎缩侧索硬化症中的脂质稳态与下丘脑功能障碍关联起来 Sruthi Sankari KrishnamurthyAdriana Zardini BuzattoFrancesco Roselli Research 03 March 2026 Article: 210 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Day+30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML 移植后第30天通过高灵敏度PCR-NGS检测微小残留FLT3-ITD可预测急性髓系白血病（AML）复发风险并指导移植后维持治疗 Shan JiangDan FengErlie Jiang Research 03 March 2026 Article: 209 Early childhood weight gain and alanine aminotransferase at age 8: an adjunct study of the Japan Environment and Children’s Study 幼儿期体重增长与8岁时丙氨酸氨基转移酶水平：日本环境与儿童研究的一项辅助研究 Naw Awn J-PKeiko YamasakiNarufumi Suganuma Research 03 March 2026 Article: 208 Anti-CD19 chimeric antigen receptor T-cell therapy for relapsed or refractory Philadelphia chromosome-positive B cell acute lymphoblastic leukemia: a multicenter retrospective study 抗CD19嵌合抗原受体T细胞疗法治疗复发或难治性费城染色体阳性B细胞急性淋巴细胞白血病：一项多中心回顾性研究 Jinglei YuFengmei SongGuoqing Wei Research 03 March 2026 Article: 207 Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics 通过单细胞和空间转录组学鉴定人类卵巢皮质中的冷敏感生态位及可靶向的FOS/AP-1程序 Fanghao GuoDi SunWen Li Research 03 March 2026 Article: 206 Neoadjuvant camrelizumab combined with metronomic chemotherapy in patients with advanced esophageal squamous cell carcinoma: a pilot randomized phase 2 trial 卡瑞利珠单抗联合节拍化疗新辅助治疗晚期食管鳞状细胞癌：一项随机2期初步试验 Zhiming ChenWenshuai LiJie Liu Research 03 March 2026 Article: 205 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症临床试验 Vericiguat for endothelial dysfunction and CRT response in non-responders: the VERCET prospective observational study 维利西呱治疗无反应者的内皮功能障碍和心脏再同步化治疗（CRT）反应：VERCET前瞻性观察研究 Celestino SarduLudovica Vittoria MarfellaRaffaele Marfella Research 03 March 2026 Article: 204 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病和心律失常 Assessment of antibody responses to Anopheles SG6-P1 and Aedes N-term 34kDa salivary peptides: a randomised human-challenge trial of controlled exposures to vector bites 评估针对按蚊SG6-P1和伊蚊N端34 kDa唾液肽的抗体反应：一项对媒介叮咬进行可控暴露的随机人体挑战试验 Victor ChaumeauEllen A. KearneyFreya J. I. Fowkes Research 02 March 2026 Article: 203 Is random biopsy necessary for normal esophageal mucosa during chromoendoscopy? Evidence from a population-based cohort study 在色素内镜检查过程中，对于正常食管黏膜是否有必要进行随机活检？一项基于人群的队列研究证据 Wenlei YangMengfei LiuYang Ke Research 02 March 2026 Article: 202 Sinusoidal cell–derived biomarker scores predict diagnosis and prognosis in chronic liver disease 窦状隙细胞来源的生物标志物评分可预测慢性肝病的诊断和预后 Sergi Guixé-MuntetAnabel Fernández-IglesiasJordi Gracia-Sancho Research 28 February 2026 Article: 201 Anticholinergic drug burden and incident cardiovascular events: a population-based study 抗胆碱能药物负担与新发心血管事件：一项基于人群的研究 Nanbo ZhuMaria EriksdotterHong Xu Research 28 February 2026 Article: 200 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study 从儿童期到成年期体重指数（BMI）变化对亚临床心血管结局影响的敏感期：一项为期36年的前瞻性队列研究 Hui YangTongshuai GuoJianjun Mu Research 27 February 2026 Article: 199 Feasibility and preliminary efficacy of an art-making program to manage fear of cancer recurrence (AM-I-FCR) in lung cancer patients: a randomized controlled pilot study 艺术创作项目（AM-I-FCR）管理肺癌患者对癌症复发恐惧的可行性与初步疗效：一项随机对照试点研究 Jialing LinZhixuan KangFeifei Huang Research 27 February 2026 Article: 198 Unveiling disparities in lung cancer care: a joint spatio-temporal analysis of multidisciplinary meeting presentation, supportive care screening, and diagnostic timeliness in Victoria 揭示肺癌诊疗差异：维多利亚州多学科会诊展示、支持性护理筛查及诊断及时性的联合时空分析 Getayeneh Antehunegn TesemaRob G. StirlingArul Earnest Research 27 February 2026 Article: 197 Transcriptome-based high-frequency recurrence index predicts frequent recurrence in non-muscle-invasive bladder cancer after Bacillus Calmette-Guérin therapy 基于转录组的高频复发指数可预测卡介苗治疗后非肌层浸润性膀胱癌的频繁复发情况 Seung-Woo BaekYoung Joon ByunSeok Joong Yun Research 27 February 2026 Article: 196 Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study 出生体重对健康老龄化的终身影响及后续途径：一项孟德尔随机化研究 Lijie KongChun DouTiange Wang Research 25 February 2026 Article: 195 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Routine inflammatory indices modify clonal hematopoiesis-related prognostic risk in patients undergoing percutaneous coronary intervention: a real-world cohort study 常规炎症指标改变接受经皮冠状动脉介入治疗患者的克隆性造血相关预后风险：一项现实队列研究 Xuxiang ShenYing SongXiangfeng Lu Research 25 February 2026 Article: 194 Health experiences and outcomes of autistic and non-autistic adults with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder 自闭症和非自闭症成年孤独症患者及非孤独症患者中患有高迁移率埃勒斯-丹洛斯综合征和高迁移率谱系障碍者的健康体验和预后 Catherine J. CromptonThemis N. EfthimiouKathryn M. Berg Research 25 February 2026 Article: 193 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Effects of non-pharmacological interventions on sleep quality in older adults: a systematic review and network meta-analysis of randomized controlled trials 非药物干预措施对老年人睡眠质量影响：基于随机对照试验的系统综述和网络荟萃分析 Jia SongHeng DongShangfeng Tang Research 25 February 2026 Article: 192 Cortical excitability mapping stratifies neurobiological subtypes of schizophrenia with genetic and molecular signatures 皮质兴奋性映射对具有遗传和分子特征的精神分裂症神经生物学亚型进行分层 Sixuan GuoYu ZhaoQiyong Gong Research 25 February 2026 Article: 191 Minimum 18-week chemotherapy improves survival in locally advanced rectal cancer after neoadjuvant radiotherapy: a post hoc analysis of the STELLAR trial 新辅助放疗后局部晚期直肠癌患者接受至少18周化疗可改善生存率：STELLAR试验的事后分析 Tongzhen XuHuiying MaJing Jin Research 25 February 2026 Article: 190 Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria 在莫桑比克患疟疾的儿童中，蠕虫共感染可减轻临床、寄生虫学和免疫学转归 Inocência CuambaRebeca SantanoCarlota Dobaño Research 31 March 2026 Article: 189 Effectiveness of group-based art interventions for late-life depression: a systematic review and meta-analysis of randomized controlled trials 团体艺术干预对老年抑郁症的疗效：一项针对随机对照试验的系统综述和荟萃分析 Mohamad AzhdarlooRaziyeh AtaeiAbouzar Nazari Research 24 February 2026 Article: 188 The associations of consultant sex on herding‑like prescribing behaviour: evidence from a web-based experiment with female primary care physicians in England 顾问性别对从众式处方行为的影响：来自一项针对英格兰女性初级保健医生的网络实验的证据 Sandro Tiziano StoffelMatthias SchwenkglenksBerna Cennet Özdemir Research 24 February 2026 Article: 187 Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients 三羧酸循环代谢物指数预测急性心肌梗死患者的不良预后 Ye WangPengyan WuBo Yu Research 24 February 2026 Article: 186 Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids 靶向癌症干细胞可预测腹水来源的卵巢癌类器官的反应并逆转化疗耐药性 Xiaoli ZhangWen ZhangHuiqin Guo Research 24 February 2026 Article: 185 Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk 青少年神经对压力的易感性：一项使用抑郁风险多连接组评分进行的纵向研究 Yuan LiuMeijuan LiJie Li Research 24 February 2026 Article: 184 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Classification of ALS molecular subtypes: a literature review on machine learning applications and their clinical value 肌萎缩侧索硬化症分子亚型分类：机器学习应用及其临床价值的文献综述 John K. JammalEsteban A. GomezAlfredo Iacoangeli Review 23 February 2026 Article: 183 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Can we protect refugee children from mental health problems?— a scoping review of modifiable factors to inform preventive interventions 我们能否保护难民儿童免受心理健康问题困扰？——一项旨在为预防性干预提供信息的可改变因素的范围性综述 Rita GonçalvesM J MarquesSónia Dias Research 23 February 2026 Article: 182 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 The Trial Bank initiative to promote trustworthy living evidence for medication safety (PROMISE) of children: design and pilot validation 促进儿童用药安全可信实时证据（PROMISE）的试验库计划：设计与初步验证 Chang XuSuhail A. DoiPROMISE Collaborative Research Network Research 21 February 2026 Article: 181 Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania 液体活检是否为诊断坦桑尼亚儿童和青年成人伯基特淋巴瘤的一种具有成本效益的方法？一项卫生经济学评估 Jingjing JiangLiz MorrellAI-REAL Consortium Research 21 February 2026 Article: 180 The influence of immunohistochemistry-based subtypes on overall survival in breast cancer spine metastases: a systematic review and meta-analysis 基于免疫组织化学的亚型对乳腺癌脊柱转移总生存期的影响：一项系统综述和荟萃分析 Fon-Yih TsuangYun-Heng LiChung Liang Chai Research 21 February 2026 Article: 179 Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children 产前接触母体哮喘及哮喘药物与神经发育结局的关系：一项针对179,024例儿童的人群队列研究 Lama A. ShakhshirSarjit SinghMichael Fleming Research 20 February 2026 Article: 178 First-in-human phase 1/2a study of T3011, an oncolytic HSV expressing IL-12 and PD-1 antibody, administered via intratumoral (IT) injection as monotherapy in advanced solid tumors, including recurrent or metastatic HNSCC T3011（一种表达IL-12和PD-1抗体的溶瘤性单纯疱疹病毒）首次人体1/2a期研究：通过瘤内（IT）注射作为单一疗法治疗包括复发或转移性头颈部鳞状细胞癌在内的晚期实体瘤 Dongmei JiWenmin FuXichun Hu Research 20 February 2026 Article: 177 Expanding access to cerebrovascular imaging with routine MRI for pre-surgical assessment of intracranial tumor patients: an AI model development and multi-center validation study 利用常规MRI扩大脑血管成像在颅内肿瘤患者术前评估中的应用范围：一项人工智能模型开发与多中心验证研究 Chaoyue ChenZhouyang HuangJianguo Xu Research 20 February 2026 Article: 176 Changing landscape of physical fitness and urban–rural inequalities: evidence from 1.2 million children and adolescents over 20 years of urbanization 20年城市化进程中120万例儿童和青少年体质健康状况及城乡差异的变化 Shan CaiJiaxin LiYi Song Research 19 February 2026 Article: 175 Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis 抗糖尿病前期药物在糖尿病前期患者中的疗效和安全性：一项贝叶斯网状荟萃分析 Yike WuZihan WangGuo Ma Research 19 February 2026 Article: 174 Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders Yuefeng YuChenyi WanNingjian Wang 意义未明的克隆性造血与新发精神障碍风险 Research 18 February 2026 Article: 173 Spatial characterization of intrahepatic fat deposition across steatotic liver disease subcategories: a multicenter study 脂肪性肝病各亚类中肝内脂肪沉积的空间特征：一项多中心研究 Yan-Ci ZhaoMin WangFeng Chen Research 18 February 2026 Article: 172 Pregnancy outcomes among medically complex populations with high risk of pregnancy mortality in Virginia: a retrospective observational study 弗吉尼亚州妊娠死亡高风险医学复杂人群的妊娠结局：一项回顾性观察研究 Michael J. GreenLauren G. AndersonJonas J. Swartz Research 18 February 2026 Article: 171 Maternal amino acid metabolites during pregnancy and preterm birth: results from two prospective cohort studies 孕期母体氨基酸代谢物与早产的关系：两项前瞻性队列研究的结果 Jingnan ChenYidan DongJu-Sheng Zheng Research 18 February 2026 Article: 170 Correction: Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications 更正：停用抗肥胖药物后体重的变化轨迹 Han WuWenjia YangLinong Ji Correction 25 March 2026 Article: 169 Physical activity patterns and cardiovascular disease risk in adults with overweight or obesity: a prospective cohort study 超重或肥胖成人身体活动模式与心血管疾病风险：一项前瞻性队列研究 Kai MuYanan QiaoBo Xi Research 16 February 2026 Article: 168 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减肥干预措施及其对健康的影响 Maternal migraine and offspring ADHD: triangulating the evidence 母亲偏头痛与后代多动症（ADHD）：多方证据综合分析 Yaxin LuoChristina DardaniEvie Stergiakouli Research 14 February 2026 Article: 167 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson’s disease 靶向NLRP3的自主性小干扰RNA（siRNA）递送系统：在帕金森病中的潜在意义 Lishan LinZhizong LiZhong Pei Research 12 February 2026 Article: 166 Lay descriptions of painful temporomandibular disorders—an international consensus proposal for Global Burden of Disease estimates 颞下颌关节紊乱病疼痛的通俗描述——全球疾病负担评估的国际共识提案 A. LövgrenP. LivP. Svensson Research 17 March 2026 Article: 165 Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study 可溶性肿瘤坏死因子受体1与tau蛋白病变、脑萎缩及认知功能下降的关联：一项纵向研究 Yutong ZhangLulu SunAlzheimer’s Disease Neuroimaging Initiative Research 11 February 2026 Article: 164 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Particulate matter and respiratory health in middle-aged and older adults: disentangling size-fractionated and constituent-specific effects under China’s clean-air policies 颗粒物与中老年人呼吸系统健康的关系：厘清中国净化空气政策下不同粒径及成分的特定影响 Yujing ChenZhaoyan LiuYu-ming Chen Research 11 February 2026 Article: 163 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Clinical impact and cost-effectiveness of vaccinating infants and adolescents against invasive meningococcal B disease in the Netherlands 荷兰为婴儿和青少年接种针对侵袭性脑膜炎球菌B病的疫苗的临床影响和成本效益 Thomas OttenMirjam KnolAnneke Steens Research 10 February 2026 Article: 162 Association between trajectories of sleep quality and postpartum depression: a group-based trajectory model and computer-simulated network analysis 睡眠质量轨迹与产后抑郁之间的关联：基于组别的轨迹模型和计算机模拟网络分析 Xiaoxiao MeiJinzhou YuZengjie Ye Research 10 February 2026 Article: 161 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Understanding Japan’s mortality advantage: a comparison of mortality in independent and dependent older adults in Japan and Sweden 解读日本在死亡率方面的优势：日本与瑞典独立生活及依赖他人生活老年人的死亡率比较 Shunsuke MurataMarcus EbelingKarin Modig Research 23 March 2026 Article: 160 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用 The Young Adult Sleep model: an evolving causal loop diagram of mental health dynamics 青年睡眠模型：心理健康动态演变的因果环路图 Jeroen F. UlemanRushd F. M. Al-ShamaNaja Hulvej Rod Research 16 March 2026 Article: 159 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma 基于抑瘤素M配体的CAR-T疗法对骨肉瘤显示出强大的抗肿瘤活性 Daniel FeinbergVinayak UppinReshmi Parameswaran Research 17 March 2026 Article: 158 Antimicrobial catheters coated with poly-L-lysine for the prevention of bacteriuria in adults requiring short-term catheterization: a multicenter randomized controlled trial 涂有聚-L-赖氨酸的抗菌导管预防短期导尿成人患者菌尿症：一项多中心随机对照试验 Xinfei LiJun LiuKai Zhang Research 09 February 2026 Article: 157 Penpulimab in combination with lenalidomide and R-GemOx regimen (R2-GemOx-PD1i) in relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm, phase 2 trial 派安普利单抗联合来那度胺和R-GemOx方案（R2-GemOx-PD1i）治疗复发或难治性弥漫性大B细胞淋巴瘤：一项多中心、单臂、2期试验 Jin-Hua LiangTong-Yao XingWei Xu Research 09 February 2026 Article: 156 Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus 数字孪生大脑揭示耳鸣异常脑动力学状态特异性刺激靶点 Jiaqi ZhangShuting HanTianzi Jiang Research 10 February 2026 Article: 155 The case for mandatory reporting to enable targets for healthy and environmentally sustainable food: means, motive and opportunity 强制报告实现健康且环境可持续食物目标的理由：方法、动机和机会 Rachel PecheyLauren BandySusan A. Jebb Debate 10 February 2026 Article: 154 Genetic insights into radiomic and proteomic changes under β1-blockers treatment in hypertensive heart disease and hypertrophic cardiomyopathy β1受体阻滞剂治疗高血压性心脏病和肥厚型心肌病时放射组学和蛋白质组学变化的遗传学见解 Zhe ChenYifan TangKai Xie Research 09 February 2026 Article: 153 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病与心律失常 Optimizing drug-resistant tuberculosis diagnosis: cost-effectiveness of rapid molecular and phenotypic assays in South Africa 优化耐药结核病诊断：南非快速分子和表型检测方法的成本效益分析 Ginenus FekaduTadesse TolossaWai Kit Ming Research 09 February 2026 Article: 152 Maternal smoking based on pre-birth health examination and risk of neurodevelopmental disorders in offspring: insights from a Korean mother–child cohort 基于产前健康检查探讨母亲吸烟与后代神经发育障碍风险的关系：来自韩国母婴队列研究的见解 Chan Soon ParkMoonyoung JangJun-Bean Park Research 11 March 2026 Article: 151 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Effects of ablation versus drug therapy on clinical outcomes and quality of life by frailty status in atrial fibrillation: a post hoc analysis of the CABANA trial 根据衰弱状态分析消融术与药物治疗对心房颤动患者临床预后和生活质量的影响：CABANA试验的事后分析 Lili WangYanguang LiYunlong Wang Research 07 February 2026 Article: 150 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病与心律失常 Quantifying lifetime risk for 1,401 infectious diseases across the diabetes spectrum using a Bayesian approach 采用贝叶斯方法量化糖尿病全病程中1401种传染病的终生风险 Boomer B. OlsenMartin Tristani-FirouziEdgar Javier Hernandez Research 07 February 2026 Article: 149 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与传染病 Risk assessment of asthma and allergic rhinitis in atopic dermatitis patients treated with biologics and JAK inhibitors: a systematic review and network meta-analysis of randomized controlled trials 对接受生物制剂和JAK抑制剂治疗的特应性皮炎患者罹患哮喘和过敏性鼻炎的风险评估：一项针对随机对照试验的系统综述和网络荟萃分析 Liling ZengTong ZhouJing Li Research 07 February 2026 Article: 148 Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma 布林西多福韦（brincidofovir）在外周T细胞和NK/T细胞淋巴瘤中的临床前活性 Jason Yongsheng ChanElizabeth Chun Yong LeeChoon Kiat Ong Research 06 February 2026 Article: 147 Genetic risk factors modulate the association between physical activity and colorectal cancer 遗传风险因素调节身体活动与结直肠癌之间的关联 Anita R. PeoplesMireia Obón-SantacanaVictor Moreno Research 05 February 2026 Article: 146 A neuroimaging biomarker for disease staging in clinically diagnosed Alzheimer’s disease 临床诊断阿尔茨海默病的疾病分期神经影像学标志物 Zhuangzhuang LiShaozhen YanYong Liu Research 05 February 2026 Article: 145 Association of GLP-1 receptor agonists with herpes risks in diabetes mellitus: a target trial emulation 胰高血糖素样肽-1（GLP-1）受体激动剂与糖尿病中疱疹风险的关联：一项目标试验模拟研究 Chi-Hsien HuangI-Hui ChiangJames Cheng-Chung Wei Research 31 December 2025 Article: 144 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial 局部晚期胃癌联合胸腺肽的新辅助免疫化疗：一项前瞻性临床试验 Hao XuFengyuan LiZekuan Xu Research 26 February 2026 Article: 143 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症的临床试验 Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis 临床医生在临床复查中检测急性脑膜炎后遗症：一项系统综述和荟萃分析 Luisa F. AlvizCarla Y. KimKiran T. Thakur Research 28 February 2026 Article: 142 Part of 1 collection:Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述合集 ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics ISG15驱动的免疫调节与乳腺癌转移中的肿瘤进展：来自单细胞和空间转录组学的见解 Hua ShaoHanlu TangYongqing Xu Research 04 February 2026 Article: 141 Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk 评估家族史和多基因风险评分对心代谢疾病风险的影响 Ebuka OnyenobiKnightess OyiboSally N. Adebamowo Research 03 February 2026 Article: 140 Social networking site use, depressive and anxiety symptoms in adolescents: evidence from a longitudinal cohort study (SCAMP) 社交网站使用与青少年抑郁和焦虑症状：来自纵向队列研究（SCAMP）的证据 Chen ShenBraulio M. Girela-SerranoMireille B. Toledano Research 03 February 2026 Article: 139 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel 使用经验证的三蛋白血清生物标志物组合进行早孕期自发性早产预测 Qiong LuoJuan WeiXuefeng B. Ling Research 02 February 2026 Article: 138 Household cannabis cessation and adolescent mental health outcomes in a prospective cohort study 一项前瞻性队列研究中家庭大麻戒断与青少年心理健康预后的关系 Ming WangYixiang XuFei Li Research 02 February 2026 Article: 137 Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies 所属专题合集：精神活性物质：娱乐性药物重新利用为新型疗法 Objective assessment of long-term impact of COVID-19 on multiple sensory functions 客观评估新冠肺炎对多种感觉功能的长期影响 Ahmad OdehVeronica L. FormanekKai Zhao Research 27 February 2026 Article: 136 Detection of hearing loss by formal audiological testing after acute infectious meningitis: a global systematic review and meta-analysis 急性感染性脑膜炎后通过正式听力检测诊断听力损失：一项全球系统综述和荟萃分析 Luisa F. AlvizCarla Y. KimKiran T. Thakur Review 28 February 2026 Article: 135 Part of 1 collection: Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述合集 Serological evidence of substantial respiratory syncytial virus infection burden among older adults residing in Swedish long-term care facilities 血清学证据表明，居住在瑞典长期护理机构中的老年人存在沉重的呼吸道合胞病毒感染负担 Preeti MoarChristoffer GranvikMattias N. E. Forsell Research 24 February 2026 Article: 134 Association of parental education with offspring psychiatric diagnoses, violent crimes, and suicidal behavior: a nationwide Swedish quasi-experimental study 父母受教育程度与后代精神疾病诊断、暴力犯罪和自杀行为之间的关联：一项瑞典全国范围的准实验研究 Mengping ZhouHenrik LarssonErik Pettersson Research 26 February 2026 Article: 133 Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis 外部验证的痴呆风险预测模型的鉴别性能：一项系统综述和荟萃分析 Blossom C. M. StephanJacob BrainMario Siervo Research 02 February 2026 Article: 132 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study 静脉注射大剂量硒预防铂敏感复发性卵巢癌化疗所致周围神经病变的有效性和安全性：一项3期、双盲、平行组、随机对照试点研究 Ga Won YimKyung Hee HanHee Seung Kim Research 02 February 2026 Article: 131 Time for change in implementation research and practice 实施研究和实践中变革的时机已到 Mike EnglishJacob McKnightSebastian Fuller Debate 02 February 2026 Article: 130 CardioMetAge estimates cardiometabolic aging and predicts disease outcomes CardioMetAge可评估心脏代谢年龄并预测疾病结局 Yucan LiXinming XuKelin Xu Research 31 January 2026 Article: 129 Disproportionate climate burden of rising temperatures on low birth weight in Pakistan 气温上升给巴基斯坦低出生体重儿带来的不成比例的气候负担 Syeda H. FatimaCorey J. A. BradshawZohra S. Lassi Research 31 January 2026 Article: 128 Part of 1 collection: Climate change and human health 所属专题：气候变化与人类健康 Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy 利用靶向CD3ε、EpCaM和4-1BB的三特异性T细胞衔接器增强溶瘤病毒疗法：临床前评估及对癌症免疫疗法的启示 Zhongyi DongHaoyu ZhangZizhen Zhang Research 30 January 2026 Article: 127 Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma 靶向降解BCL-XL与吉西他滨联用对胆管癌具有协同治疗作用 Qinghua ZengYan ZhangYonghan He Research 30 January 2026 Article: 126 Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4 DNA甲基化与高血压及血压的关联：来自KORA F4/FF4的7年纵向研究 Liye LaiAngelina Shin Yee JongMelanie Waldenberger Research 04 February 2026 Article: 125 Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis 精神活性物质使用与泛癌症的共享遗传结构：来自大规模全基因组跨性状分析的见解 Jiahang SongPengzhu LiOlivier Gires Research 05 February 2026 Article: 124 Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies 所属专题：精神活性物质：作为新型疗法的娱乐性药物再利用 Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children 宫内暴露于母体糖尿病与儿童患癫痫风险的关系：一项针对230万儿童的全国队列研究 Muhammad Zakir HossinMartina PerssonNeda Razaz Research 14 February 2026 Article: 123 ADHD and adherence to antihypertensive medication treatment: a multinational cohort study 多动症与坚持抗高血压药物治疗的关系：一项多国队列研究 Honghui YaoYiling ZhouZheng Chang Research 20 February 2026 Article: 122 How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project 重新加入长期减肥计划的效果如何？5年和10年磁共振成像评估的随访干预试验（FIT）项目 Hadar KleinDafna PachterIris Shai Research 30 January 2026 Article: 121 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减肥干预措施及其对健康的影响 Correction: Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings 更正：精神分裂症患者及其未受影响兄弟姐妹的脑状态动态与工作记忆 Feiwen WangJie YangLena Palaniyappan Correction 20 February 2026 Article: 120 Ocular light and optical radiation exposure as a modifiable environmental determinant of health: expert consensus on research gaps and priorities 作为可改变的环境健康决定因素的眼睛光暴露和光学辐射暴露：关于研究空白和优先事项的专家共识 Manuel SpitschanAnna M. BillerJohannes Zauner Guideline 29 January 2026 Article: 119 Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study 青少年饮食模式与神经心理功能：一项横断面和纵向研究 Alexios ManidisNicolas Ayala-AldanaJordi Julvez Research 29 January 2026 Article: 118 Part of 1 collection: Child and adolescent psychiatry 所属专题：儿童与青少年精神病学 Factors impacting the delivery of contextualized care in serious illness: a focus group study with healthcare professionals 影响危重症患者情境化护理实施的因素：一项针对医疗保健专业人员的焦点小组研究 Linda ModderkolkYvonne SchoonAnne B. Wichmann Research 29 January 2026 Article: 117 Part of 1 collection: Palliative care and medicine 所属专题：姑息治疗与医学 Early interventions for first onset of symptoms of mental health conditions: an umbrella review of systematic reviews 针对心理健康问题首次出现症状的早期干预措施：一项系统综述的伞式评价 Jasmine LeePhoebe BarnettSonia Johnson Research 29 January 2026 Article: 116 Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone 局灶性癫痫发作间期脑电图信号中嵌入的谐波模式：对致痫区的新见解 Lingli HuLingqi YeShuang Wang Research 28 January 2026 Article: 115 Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题合集：癫痫：发作预防、治疗和流行病学 Effects of aerobic or resistance exercise on sleep and cancer-related fatigue in patients with breast cancer during or after neoadjuvant chemotherapy: a 3-arm randomized controlled trial 有氧运动或抗阻运动对新辅助化疗期间或之后乳腺癌患者睡眠和癌症相关疲劳的影响：一项三臂随机对照试验 Alexander HaussmannMartina E. SchmidtKaren Steindorf Research 28 January 2026 Article: 114 Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis 中性粒细胞甲基丙二酸通过激活IL-6信号通路介导的中性粒细胞胞外诱捕网形成（NETosis），促进心肌梗死后微血栓形成和不良心脏重构 Yige LiuJiaxin WangShaohong Fang Research 28 January 2026 Article: 113 Statistical approaches to analyse the combined effect of seven air pollutants and breast cancer risk: a case–control study nested in the French E3N-Generations cohort 分析七种空气污染物联合作用与乳腺癌风险关系的统计方法：一项嵌套于法国E3N-Generations队列的病例对照研究 Camille GiampiccoloBéatrice FerversAmina Amadou Research 28 January 2026 Article: 112 Part of 1 collection: Carcinogens and human health 所属专题合集：致癌物与人类健康 Is behaviour change communication guidance for general practice healthcare professionals evidence based? A systematic review 针对全科医疗保健专业人员的行为改变沟通指导是否具有循证依据？一项系统综述 Anika Schwarze-ChintapatlaJonathan Livingstone-BanksCharlotte Albury Research 16 February 2026 Article: 111 Patient-centred postpartum care provision: virtual delivery, tiered escalation, and tensions between efficiency, preference, and clinical concern 以患者为中心的产后护理服务提供：虚拟服务模式、分级转诊机制，以及效率、患者偏好与临床关切之间的矛盾 Sergio A. SilverioJulia R. B. BrownEmma L. Duncan Research 24 February 2026 Article: 110 Ethical dilemmas in climate change and healthcare delivery: a cross-sectional survey of US patient perspectives 气候变化与医疗服务中的伦理困境：一项针对美国患者观点的横断面调查 Andrew HantelEmily SenayGregory A. Abel Research 27 January 2026 Article: 109 Part of 1 collection: Climate change and human health 所属专题：气候变化与人类健康 Inetetamab plus camrelizumab and utidelone for pretreated HER2-positive advanced breast cancer: a prospective, single-arm, phase 2 study 伊尼妥单抗联合卡瑞利珠单抗和优替德隆治疗既往接受过治疗的HER2阳性晚期乳腺癌：一项前瞻性、单臂、2期研究 Huimin LvTao SunMin Yan Research 27 January 2026 Article: 108 Potential of earlier primary care health checks for prevention of cardiovascular events in younger age groups: population-based study in the United Kingdom 早期初级保健健康检查对预防年轻人群心血管事件的潜力：英国一项基于人群的研究 Catherine A. ScottLinxin LiPeter M. Rothwell Research 24 January 2026 Article: 107 Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis 盐替代品对血压、心血管事件和死亡率影响的比较：一项系统综述和网络荟萃分析 Honghao LaiGihad NesrallahBradley C. Johnston Research 23 January 2026 Article: 106 Association of short-term exposure to ambient air pollutants with liver function and mediation by fasting insulin: evidence from a rural cohort in China 短期暴露于环境空气污染物与肝功能的关系及空腹胰岛素的中介作用：来自中国农村队列研究的证据 Mengxin WangAogang ZhangWeidong Wu Research 23 January 2026 Article: 105 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Adjuvant tislelizumab, lenvatinib, and capecitabine for resected biliary tract cancer: a prospective phase II trial 辅助治疗：替雷利珠单抗、仑伐替尼和卡培他滨用于可切除的胆道癌：一项前瞻性II期试验 Yun FengNing ZhangLu Wang Research 23 January 2026 Article: 104 Comparative effectiveness of sleeve gastrectomy and semaglutide for weight loss and metabolic outcomes: a prospective non-randomized study 袖状胃切除术与司美格鲁肽对减重及代谢结局的疗效比较：一项前瞻性非随机研究 Yutung YenQian ZhangYi Chen Research 22 January 2026 Article: 103 Part of 1 collection:Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响 Impact of sex on outcomes in patients treated with drug-coated balloons versus drug-eluting stents for de novo coronary artery lesions: Insights from the REC-CAGEFREE I trial 性别对接受药物涂层球囊与药物洗脱支架治疗的新发冠状动脉病变患者预后的影响：来自REC-CAGEFREE I试验的见解 Ping WangJingyu ZhouLing Tao Research 22 January 2026 Article: 102 Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models 通过多基因风险评分和时间事件模型评估哮喘与抑郁的共病情况 Xueting WangJun HeRenato Polimanti Research 22 January 2026 Article: 101 Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition 严重营养不良儿童出院后持续存在的免疫、凝血和心脏功能失调与后期死亡率相关 Brenda KamauEvans O. MudiboJames M. Njunge Research 22 January 2026 Article: 100 Correction: Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022 更正：计算机辅助口头尸检：对比大型语言模型与医生为2019 - 2022年塞拉利昂6939例死亡分配病因的情况 Richard WenAnteneh Tesfaye AssalifRashid Ansumana Correction 14 February 2026 Article: 99 Characteristics of parks associated with depression in women only: a cross-sectional study of 329,363 adults 仅与女性抑郁相关的公园特征：一项针对329,363名成年人的横断面研究 Jonathan R. OlsenNatalie NichollsRichard Mitchell Research 21 January 2026 Article: 98 Weight change mediates the effect of lifestyle intervention on postpartum diabetes in women with prior gestational diabetes: a secondary analysis of a randomized clinical trial 在生活方式干预对既往妊娠期糖尿病女性产后糖尿病影响中，体重变化的中介作用：一项随机临床试验的二次分析 Weiqin LiHuikun LiuGang Hu Research 21 January 2026 Article: 97 Part of 1 collection: Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与治疗 Global drivers of heart failure attributable to atrial fibrillation/flutter: insights fromJoinpoint regression, age-period-cohort analysis, and future projections from the GBD 2021 Study 心房颤动/扑动所致心力衰竭的全球驱动因素：来自折点回归、年龄-时期-队列分析以及2021年GBD（全球疾病负担）研究未来预测的见解 Jing ChenZhu LiGregory Y. H. Lip Research 20 January 2026 Article: 96 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Overdiagnosis of gestational diabetes mellitus during Ramadan: a retrospective population-based study in Catalonia, Spain 斋月期间妊娠期糖尿病的过度诊断：西班牙加泰罗尼亚地区一项基于人群的回顾性研究 Marta CarrascoBogdan VlachoMarta Hernández Research 20 January 2026 Article: 95 Part of 1 collection: Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与管理 Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England 为何当前基于风险因素的方法在预测死胎方面存在不足：英格兰初产妇全国队列研究 A. HowellB. ThilaganathanTommy’s National Centre for Maternity Improvement Research 22 January 2026 Article: 94 Pay-it-forward intervention increased pneumococcal vaccine uptake among older adults in China: a randomized controlled trial 爱心传递干预措施提高了中国老年人肺炎球菌疫苗的接种率：一项随机对照试验 Jiao QinChunxing TaoBingyu Liang Research 19 January 2026 Article: 93 The impact of e-cigarette taxation: a systematic review and meta-analysis on usage, pricing strategies, and public health implications 电子烟税收的影响：针对使用情况、定价策略和公共卫生影响开展的系统综述和荟萃分析 Quan WangZheng ZhuLi Yang Research 17 January 2026 Article: 92 Safety and preliminary efficacy results of IBI389, an anti-Claudin18.2×CD3 bispecific antibody, in patients with solid tumors and gastric or gastro-esophageal tumors: a phase 1 dose escalation and expansion study 抗Claudin18.2×CD3双特异性抗体IBI389在实体瘤及胃或胃食管肿瘤患者中的安全性与初步疗效结果：一项1期剂量递增与扩展研究 Xiaoyu LiRuihong DaiFeng Bi Research 16 January 2026 Article: 91 Part of 1 collection: Clinical trials for gastrointestinal cancer 所属专题：胃肠道癌症临床试验 Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study 比较非癌症疼痛使用阿片类药物者发生谵妄的风险：一项回顾性队列研究 Carlos Raul Ramirez MedinaMark LuntMeghna Jani Research 31 January 2026 Article: 90 Association between preoperative interruption of antiplatelet therapy and postoperative thrombotic risk after minimally invasive surgery for abdominopelvic cancer in patients treated with P2Y12 inhibitors 接受P2Y12抑制剂治疗的患者行腹部盆腔癌症微创手术时，术前中断抗血小板治疗与术后血栓形成风险之间的关联 Masashi KubotaSatomi YoshidaKoji Kawakami Research 16 January 2026 Article: 89 Comparative outcomes of distal ureterectomy vs. radical nephroureterectomy in high-risk distal ureteral urothelial carcinoma: a two-center cohort study in Northern and Southern China 高危远端输尿管尿路上皮癌患者行远端输尿管切除术与根治性肾输尿管切除术的疗效比较：中国北方和南方两家中心的队列研究 Junyi XieZhenhua LiuWei Yu Research 16 January 2026 Article: 88 Co-occurrence patterns and related risk factors of dementia and Parkinson’s disease among older adults across 204 countries and territories: a spatial correspondence and systematic analysis 204个国家和地区老年人痴呆症与帕金森病共现模式及相关危险因素：空间对应与系统分析 Weiyang ChenMin DuJue Liu Research 15 January 2026 Article: 87 Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study 肌萎缩侧索硬化症加速脑衰老及其预后关联：一项队列研究 Chenhao FangJiaoting JinShuoqiu Gan Research 15 January 2026 Article: 86 Part of 1 collection: Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题：肌萎缩侧索硬化症：最新进展与新动态 The clinical effects and cortical mechanism of rTMS in poststroke lateropulsion: a randomized controlled trial 重复经颅磁刺激（rTMS）对脑卒中后侧方倾倒的临床效果及皮质机制：一项随机对照试验 Lijiao MengRaymond C. C. TsangQuan Wei Research 14 January 2026 Article: 85 5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice 中脑背侧缝际核谷氨酸能神经元中的5-HT2C受体调控小鼠疼痛与焦虑共病 Qi ZhangLi XieRiyue Jiang Research 13 January 2026 Article: 84 The clinical landscape of POLE-mutant colorectal cancer: a retrospective analysis of real-world outcome POLE突变型结直肠癌的临床现状：一项现实结局的回顾性分析 Ting XuXuhui ZhangJian Li Research 13 January 2026 Article: 83 The efficacy and safety of duloxetine in treating refractory chronic cough: a randomized clinical trial 度洛西汀治疗难治性慢性咳嗽的有效性和安全性：一项随机临床试验 Shengyuan WangHeng WuXianghuai Xu Research 13 January 2026 Article: 82 Impact of diagnosis to ablation time on clinical outcomes in patients with atrial fibrillation: post hoc analysis of the CABANA trial 心房颤动患者从诊断到消融的时间对临床预后的影响：CABANA试验的事后分析 Manlin ZhaoYang ChenGregory Y. H. Lip Research 12 January 2026 Article: 81 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Elevated maternal pre-transfer serum lipid peroxidation is associated with implantation failure and early pregnancy loss 母体转运前血清脂质过氧化水平升高与着床失败和早期流产相关 Zhangwei JiaJunxiang RenJunhao Yan Research 12 January 2026 Article: 80 Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer 幽门螺杆菌感染对肠道和肿瘤内微生物组的影响及其与胃肠道癌症免疫治疗反应的关联 Keren JiaYang ChenLin Shen Research 12 January 2026 Article: 79 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物组：人类疾病的新疗法 SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis SGLT-2抑制剂在2型糖尿病合并代偿性肝硬化患者中的应用及其对肝脏相关预后和死亡率的影响 Tien-Shin ChouDaniel Hsiang-Te TsaiEdward Chia-Cheng Lai Research 12 January 2026 Article: 78 Extrapolating from trials to clinic: a predictive model defining the boundaries of benefit for multiple sclerosis therapies in real-world populations based on systematic review 从试验外推至临床：基于系统综述构建预测模型，界定多发性硬化症疗法在现实人群中的获益边界 Bibiana BielekovaTianxia WuMichael Calcagni Research 10 January 2026 Article: 77 A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data 利用最少患者数据早期预测坏死性软组织感染A组链球菌病因的验证模型 Sonja KatzJaco SuijkerEdoardo Saccenti Research 10 January 2026 Article: 76 Trends in lipid-lowering therapies in acute coronary syndromes after Chinese new insurance policy: a real-world analysis 中国新医保政策实施后急性冠状动脉综合征患者降脂治疗趋势：一项现实情况分析 Xin ZhaoShujing WuJunbo Ge Research 09 January 2026 Article: 75 Fragmented healthcare and effective maternal coverage in Mexico, 2009–2023 2009-2023年墨西哥医疗体系碎片化与有效孕产妇医疗保障 Edson Serván-MoriDiego Cerecero-GarcíaOctavio Gómez-Dantés Research 09 January 2026 Article: 74 Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models 昼夜节律紊乱与心血管疾病：基于动物模型机制证据的系统综述与荟萃分析 Mrinal K. DasEvi De RyckJohanna Samulin Erdem Research 09 January 2026 Article: 73 Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults 衰弱进展：多重共病组合模式在老年人衰弱状态转变及死亡风险预测中的作用 Rafael Ogaz-GonzálezQian ZouEva Corpeleijn Research 08 January 2026 Article: 72 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials 益生菌补充剂对健康人群肠道微生物群多样性的影响：一项针对随机对照试验的系统综述和荟萃分析 Anna Júlia ÉliásKincső Csepke Földvári-NagyLászló Földvári-Nagy Research 07 January 2026 Article: 71 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物群：人类疾病的新疗法 Pain and high-impact pain in community-dwelling older adults in Australia and relation to sociodemographic and health-related factors, including physical disability, psychological distress, and quality of life 澳大利亚社区居住老年人的疼痛及重度疼痛情况，及其与社会人口统计学因素和健康相关因素（包括身体残疾、心理困扰和生活质量）的关系 Grace JoshySaman Khalatbari-SoltaniEmily Banks Research 22 January 2026 Article: 70 Mortality and morbidity burden associated with smoking: evidence from a 1.6 million cohort in Hong Kong 与吸烟相关的死亡率和发病率负担：来自香港160万人队列研究的证据 Boyuan WangTingting ChenEric Yuk Fai Wan Research 06 January 2026 Article: 69 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Association between long-term extreme high temperature and mortality: a 9-million prospective cohort study 长期极端高温与死亡率之间的关系：一项900万人的前瞻性队列研究 Bo YinQi HuangKuiying Gu Research 06 January 2026 Article: 68 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach 利用网络毒理学和分子对接方法揭示氨甲环酸诱发癫痫的神经毒性机制 Tianyang ChenDalong LiuXiangYang Leng Research 03 January 2026 Article: 67 Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题：癫痫：癫痫发作的预防、治疗和流行病学 Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study Trop2免疫正电子发射断层扫描/计算机断层扫描（PET/CT）成像在前列腺癌中的应用：一项概念验证性转化研究 Xingru LongShuxian AnDawei Jiang Research 31 December 2025 Article: 66 Methylmalonate accumulation contributes to myocardial vulnerability post-reperfusion: a novel therapeutic target and prognostic biomarker 甲基丙二酸蓄积促进再灌注后心肌脆弱性：一种新型治疗靶点和预后生物标志物 Shanjie WangJunChen GuoShaohong Fang Research 31 December 2025 Article: 65 Prophylactic effect of intraoperative sodium oxybate on postoperative delirium in older patients undergoing major orthopedic surgery: a randomized clinical trial 术中羟丁酸钠对接受大型骨科手术的老年患者术后谵妄的预防作用：一项随机临床试验 Meiying CuiHang XuePing Zhao Research 31 December 2025 Article: 64 Part of 1 collection:Psychoactives: Recreational drugs repurposed as novel therapies 所属专题：精神活性物质：将娱乐性药物重新用于新型疗法 Prevalence of hysterectomy in urban China and associations between metabolic disorders and hysterectomy: a multicenter population-based study involving over 9 million women 中国城市子宫切除术的流行情况以及代谢紊乱与子宫切除术之间的关系：一项涉及超过900万女性的多中心人群基础研究 Yanrui BiYuan MaYing Gao Research 30 December 2025 Article: 63 Sex differences in cardiac risk and kidney function: serum creatinine versus cystatin C 心脏风险和肾功能方面的性别差异：血清肌酐与胱抑素C的对比 Nicole L. De La MataJames A. HedleyJennifer S. Lees Research 30 December 2025 Article: 62 The association of post-conization pregnancy with subsequent cervical lesions: evidence from a nationwide cohort in Sweden 锥切术后妊娠与后续宫颈病变的关联：来自瑞典全国队列研究的证据 Huan YiJimiao HuangJianguang Ji Research 29 December 2025 Article: 61 Tibial periosteal distraction for ischemic leg ulcers: animal and clinical cohort study 胫骨骨膜牵张术治疗缺血性下肢溃疡：动物及临床队列研究 Peilin ZhouWenqiang WangQikai Hua Research 28 December 2025 Article: 60 Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study 卡瑞利珠单抗联合紫杉醇和奈达铂对不可切除的晚期食管鳞癌的术前转化治疗：一项2期研究 Jinhong ZhuJinfeng ZhangJianqun Ma Research 28 December 2025 Article: 59 Clustering of cardiometabolic risk factors, physical activity, digital exclusion, and depressive symptoms trajectories in adults aged 50years and older: findings from two prospective cohort studies 50岁及以上成年人心血管代谢风险因素聚集、身体活动、数字排斥及抑郁症状轨迹：两项前瞻性队列研究的发现 Xiaosheng DongJiaqiang XiaoChengchao Zhou Research 28 December 2025 Article: 58 Eligibility of real-world patients for aspirin primary prevention trials in cardiovascular disease 现实中符合心血管疾病阿司匹林一级预防试验资格的患者情况 Michael HolderDaniel R. MoralesBruce Guthrie Research 27 January 2026 Article: 57 Polygenic risk score-guided personalized osteoporosis screening: a population-based study 基于多基因风险评分指导的个性化骨质疏松症筛查：一项基于人群的研究 Dongxue WangWen SunJianguang Ji Research 14 January 2026 Article: 56 Urea cycle modulation by combined SGLT2 inhibitors and metformin SGLT2抑制剂与二甲双胍联合用药对尿素循环的调节作用 Makoto HaradaJonathan AdamRui Wang-Sattler Research 08 January 2026 Article: 55 Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study VCP抑制剂ML240在大型动物及人视网膜外植体中的安全性和神经保护功效：一项临床前离体研究 Ana-Cristina Almansa-GarcíaAngela ArmentoBlanca Arango-Gonzalez Research 10 January 2026 Article: 54 Impact of an eight-week isocaloric vegan dietary intervention on hemogram parameters and lymphocyte subsets: a randomized-controlled trial 为期八周的等热量纯素饮食干预对血细胞参数和淋巴细胞亚群的影响：一项随机对照试验 Julian HerterFrieda StübingMaximilian Andreas Storz Research 10 January 2026 Article: 53 Association between psychosocial factors and adverse effects of light-to-moderate ambient heat in patients with chronic diseases: results of the prospective cohort study CLIMATE-II 社会心理因素与轻至中度环境热对慢性病患者不良影响之间的关联：前瞻性队列研究CLIMATE-II的结果 Ingmar SchäferValentina PauckeDagmar Lühmann Research 15 January 2026 Article: 52 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Maternal infection during pregnancy and the risk of childhood cancer: a systematic review and meta-analysis 孕期母体感染与儿童期患癌风险：一项系统综述和荟萃分析 Loviisa MulanjeLara Kim BrackmannRajini Nagrani Research 14 January 2026 Article: 51 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Supplementary biomarker testing in molecular tumor boards increases actionable therapy recommendations: a prospective real-world study of 658 patients 分子肿瘤委员会中的补充生物标志物检测增加了可采取治疗措施的建议：一项针对658例患者的前瞻性真实世界研究 Alexander ScheiterSimon MellinKirsten Utpatel Research 14 January 2026 Article: 50 Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022 计算机辅助口头尸检：对比大型语言模型与医生对塞拉利昂2019 - 2022年6939例死亡原因的判定 Richard WenAnteneh Tesfaye AssalifRashid Ansumana Research 24 December 2025 Article: 49 Loss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank Y染色体缺失及其在男性肌萎缩侧索硬化症中的影响：来自英国生物银行的研究见解 Wei-Ming SuQing-Qing DuanYong-Ping Chen Research 24 December 2025 Article: 48 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题：肌萎缩侧索硬化症：最新进展与新动态 Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner 产前脂多糖暴露通过调节间充质成纤维细胞以时间和剂量依赖性方式来影响早期肺部发育 Ying DongStefan HadzicSaverio Bellusci Research 22 December 2025 Article: 47 Life course socioeconomic trajectories and chronic disease risk in later life among 30,055 older adults across 27 European countries (the SHARE study) 27个欧洲国家30,055名老年人生命历程中的社会经济轨迹与晚年慢性疾病风险（基于SHARE研究） Taymara C. AbreuJoline W. J. BeulensJoreintje D. Mackenbach Research 20 December 2025 Article: 46 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学与风险因素的作用 Validation of a novel patient-reported measure of the burden of digital care in diabetes 由糖尿病患者报告的数字化护理负担新型测评工具的验证 Misk Al ZahidyJennifer L. RidgewayVictor M. Montori Research 20 December 2025 Article: 45 Determinants of long-term SARS-CoV-2 immune responses in asymptomatic-to-moderate COVID-19 patients in sub-Saharan Africa 撒哈拉以南非洲地区无症状至中度 COVID-19 患者长期 SARS-CoV-2 免疫应答的决定因素 Víctor L. de RiojaOdin GoovaertsGemma Moncunill Research 14 January 2026 Article: 44 Camrelizumab and apatinib in Chinese patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid cancer: an exploratory open-label, single-arm trial 卡瑞利珠单抗联合阿帕替尼治疗中国局灶性晚期或转移性放射性碘难治性分化型甲状腺癌：一项探索性开放标签单臂试验 Xin ZhangDi SunYansong Lin Research 18 December 2025 Article: 43 Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial 地中海饮食的尿液多酚特征与心血管疾病风险较低相关：PREDIMED 试验 Inés Domínguez-LópezPolina GalkinaRosa M. Lamuela-Raventós Research 18 December 2025 Article: 42 Meta-analysis and external validation of a risk model for gastrointestinal bleeding after percutaneous coronary intervention 经皮冠状动脉介入治疗后胃肠道出血风险模型的荟萃分析及外部验证 Hualong MaCong PengQiaohong Yang Research 18 December 2025 Article: 41 DNA methylation-based clocks, tobacco smoking, and lung cancer risk 基于DNA甲基化的生物钟、烟草吸烟与肺癌风险 Ricardo Cortez Cardoso PenhaJustina Ucheojor OnwukaMattias Johansson Research 17 December 2025 Article: 40 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70years old 认知功能未受损的70岁老年人基于人口的队列中，与大脑灰质模式相关的风险和保护因素 Giulia LorenzonAnna MarsegliaEric Westman Research 17 December 2025 Article: 39 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学和风险因素的作用 Street view-derived city built environment and vulnerability to temperature extremes: a nationally representative population-based cohort study 基于街景图像的城市建成环境与极端温度脆弱性：一项全国代表性人口队列研究 Wanzhou WangChao YangLuxia Zhang Research 16 December 2025 Article: 38 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity 针对病毒变异株的灭活严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）疫苗加强针可维持保护性体液免疫和细胞免疫 Constanza MéndezLinmar Rodríguez-GuilarteSusan M. Bueno Research 15 December 2025 Article: 37 Dapagliflozin alleviates sunitinib-induced cardiotoxicity through AMPKα-PPARα axis and enhances the sensitivity of renal cell carcinoma to sunitinib 达格列净通过AMPKα-PPARα轴减轻舒尼替尼诱导的心脏毒性，并增强肾细胞癌对舒尼替尼的敏感性 Shi-yu HuangMin HuLei Wang Research 15 December 2025 Article: 36 Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study 新诊断癫痫患者言语流畅性缺陷背后的网络功能障碍：一项静息态功能磁共振成像功能连接研究 Fangzhou LiuPing JiangLing Liu Research 13 December 2025 Article: 35 Part of 1 collection:Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题：癫痫：癫痫发作的预防、治疗和流行病学 Long-term quality of life in non-epithelial ovarian cancer survivors: TMRG-GINECO-Vivrovaire rare tumors case–control study 基于广西新生儿地中海贫血基因组图谱计划开展的家庭三联体/四联体分析 Coraline DubotIsabelle Ray-CoquardFlorence Joly Research 12 December 2025 Article: 34 Family trios/quartets analysis based on the Newborn Genomic Atlas for Thalassemia project in Guangxi 非上皮性卵巢癌幸存者的长期生活质量：TMRG-GINECO-Vivrovaire罕见肿瘤病例对照研究 Wei WeiChunrong GuiBaoheng Gui Research 12 December 2025 Article: 33 Hyperuricemic persons use more analgesics than normouricemic—is asymptomatic hyperuricemia really asymptomatic? 高尿酸血症患者比血尿酸正常者使用更多镇痛药——无症状性高尿酸血症真的“无症状”吗？ Janis TimsansJenni Emilia KauppiMarkku Kauppi Research 11 December 2025 Article: 32 Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses 社会孤立、孤独感与多系统医学病症：全表型组关联分析及疾病轨迹研究 Tingshan DuanZhi CaoChenjie Xu Research 10 December 2025 Article: 31 Digital marketing techniques within online food retail platforms: a scoping review 在线食品零售平台中的数字营销技巧：一项范围综述 Adyya GuptaCatherine E. HugginsAnna Peeters Research 10 December 2025 Article: 30 Dramatic increases in redundant publications in the Generative AI era 生成式人工智能时代冗余出版物数量急剧增加 Danny MaupinTulsi SuchakMatt Spick Research 09 December 2025 Article: 29 Cardiovascular risk burden and guideline-recommended lipid and blood pressure goals in an Italian Cohort: findings from the HUMTELEMED web-based platform 意大利人群心血管风险负担及指南推荐的血脂和血压目标达成情况：HUMTELEMED网络平台的发现 Matteo LandolfoAlessandro GezziRiccardo Sarzani Research 09 December 2025 Article: 28 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial Janus激酶1/2抑制剂KL130008治疗活动性类风湿关节炎的有效性和安全性：一项随机、双盲、安慰剂对照的II期试验 Yue ChengHonghu TangYi Liu Research 09 December 2025 Article: 27 Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants 子宫内膜癌的风险分层：英国生物银行129,829名参与者中多基因风险评分和体重指数的独立及联合效应 Xuemin WangLaure DossusTracy A. O’Mara Research 10 February 2026 Article: 26 Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice 孕期摄入益生菌及纯母乳喂养初乳与新生儿黄疸风险降低相关 Bekalu Kassie AlemuChi Chiu WangYao Wang Research 08 December 2025 Article: 25 Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures 绝经后女性脂肪肝具有独特的血清细胞外囊泡蛋白质组特征 Patrick PirrotteBrooke LovellJohanna K. DiStefano Research 07 December 2025 Article: 24 Global, regional, and national temporal trends in the prevalence of environmental heat and cold exposure among older adults aged 60–99 years, 1990–2021: an age-period-cohort analysis based on the Global Burden of Disease Study 2021 基于2021年全球疾病负担研究，对1990 - 2021年60 - 99岁老年人环境热暴露和冷暴露患病率的全球、区域和国家时间趋势分析：一项基于年龄 - 时期 - 队列模型的分析 Shenghao XuJing WangJianlin Xiao Research 07 December 2025 Article: 23 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models 亲环蛋白B缺乏可增强心肌能量合成，并在临床前模型中预防心力衰竭 Xiao ZongXierenayi TudiRong Tao Research 07 December 2025 Article: 22 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Normobaric hyperoxia for intracerebral hemorrhage: a randomized clinical trial 常压高氧治疗脑出血：一项随机临床试验 Zhiying ChenJiayue DingRan Meng Research 07 December 2025 Article: 21 Nationwide trends in pediatric hospitalizations for eating disorders in France between 2013 and 2022: a retrospective study using the national health insurance database Emmanuelle LogeaisFrançoise TroussierLilia Khendek 2013 - 2022年法国因进食障碍住院的儿科患者全国趋势：一项使用国家健康保险数据库的回顾性研究 Research 05 December 2025 Article: 20 Part of 1 collection:Child and adolescent psychiatry 所属专题：儿童与青少年精神病学 Self-management of vaginal pessaries for pelvic organ prolapse: multi-method process evaluation, linked to the TOPSY randomised controlled trial 盆腔器官脱垂阴道子宫托自我管理：与TOPSY随机对照试验相关的多方法过程评估 Carol BuggeMelanie Dembinskythe TOPSY team Research 05 December 2025 Article: 19 Large-scale plasma proteomics reveals bidirectional associations between sleep patterns and inflammatory bowel disease: a prospective cohort study 大规模血浆蛋白质组学研究揭示睡眠模式与炎症性肠病之间的双向关联：一项前瞻性队列研究 Kaixing LeYaru LiuZhigang Liu Research 05 December 2025 Article: 18 Association between socioeconomic status and diabetic retinopathy in individuals with type 1 diabetes: a systematic review and meta-analysis 1型糖尿病患者社会经济地位与糖尿病视网膜病变之间的关联：一项系统综述和荟萃分析 Fernando Sebastian-VallesSergio Núñez de Arenas-ArroyoJulia Martínez-Alfonso Review 05 December 2025 Article: 17 Patterns of disparity: age and socioeconomic differences in women’s smoking and quitting outcomes in Great Britain 差异模式：英国女性吸烟及戒烟结局的年龄和社会经济差异 Sarah E. JacksonCaitlin NotleySharon Cox Research 10 February 2026 Article: 16 Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression SWI/SNF复合体中的基因组致病性改变通过下调STING表达损害中国KRAS突变型非小细胞肺癌患者的免疫治疗效果 Lingling GaoJie JiangXuchao Zhang Research 03 December 2025 Article: 15 Residential radon exposure and incident myocardial infarction and stroke risks in the All of Us Research Program “我们所有人”研究项目中住宅氡暴露与心肌梗死和卒中发病风险的关系 Jiajun LuoZhihao JinBriseis Aschebrook-Kilfoy Research 03 December 2025 Article: 14 Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias 用于延缓神经退行性变的地中海饮食-终止高血压膳食疗法干预措施（MIND）与心血管疾病及心律失常的关系 Pei QinFrederick K. HoJill P. Pell Research02 December 2025 Article: 13 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population KoMethylNet：基于神经网络分析DNA甲基化数据的新型表观遗传时钟及韩国人群的表观遗传年龄加速研究 Dabin YunKwangyeon OhNan Song Research 03 December 2025 Article: 12 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants 睡眠与体力活动的权衡与痴呆风险：英国生物样本库参与者的一项前瞻性队列研究 Stephanie YiallourouLachlan CribbMatthew P. Pase Research 03 December 2025 Article: 11 Part of 1 collection: Sleep and mental health 所属专题：睡眠与心理健康 Integration of gut microbiome and lipid metabolism reveals the anti-cancer effects of pentadecanoic acid on bladder cancer 肠道微生物组与脂质代谢的整合揭示十五烷酸对膀胱癌的抗癌作用 Ya-Ting ChenJing SuiEvan Yi-Wen Yu Research 03 December 2025 Article: 10 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物群：人类疾病的新疗法 A social determinants-based county-level cardiovascular mortality index to identify high-risk counties in the USA 基于社会决定因素的美国县级心血管疾病死亡率指数，用于识别高风险县 Anqi ZhuBibhas ChakrabortyTazeen H. Jafar Research 02 December 2025 Article: 9 HIV infection and immunosenescence: challenges and intervention strategies HIV感染与免疫衰老：挑战与干预策略 Junyan JinQianqian XuBin Su Review 02 December 2025 Article: 8 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学与风险因素的作用 Machine learning-based prediction of short-term outcomes in aneurysmal subarachnoid hemorrhage: a multicenter study integrating clinical and inflammatory indicators 基于机器学习的动脉瘤性蛛网膜下腔出血短期预后预测：一项整合临床与炎症指标的多中心研究 Weichong ZhouCong PengHui Shi Research 29 November 2025 Article: 7 The effectiveness and safety of a mobile application-based self-regulation intervention to support weight loss among adults living with obesity: a large-scale pragmatic randomised controlled trial 基于移动应用程序的自我调节干预措施在支持肥胖成年人减重方面的有效性与安全性：一项大规模实用性随机对照试验 Paul DoodyGina M. WrenPaul Aveyard Research 29 November 2025 Article: 6 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响 Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults 脂肪堆积（肥胖程度）与首次确诊精神疾病的关系：一项基于1000万英国成年人的队列研究 Xue DongPaul AveyardMin Gao Research 29 November 2025 Article: 5 Efficacy of standard care versus acoustic therapy on acute tinnitus in idiopathic sudden sensorineural hearing loss: a randomized controlled trial 标准治疗与声治疗对特发性突发性感音神经性听力损失伴急性耳鸣的疗效对比：一项随机对照试验 Xinyi WangKe QiuYu Zhao Research 28 November 2025  Article: 4 Trends and socio-economic inequalities in overweight- and obesity-related premature cardiovascular disease mortality in Australia 澳大利亚超重与肥胖相关过早心血管疾病死亡的趋势及社会经济不平等状况 Tim Adair Research 29 January 2026 Article: 3 Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study 评估孕期母体血压对围产期健康的影响：一项广角孟德尔随机化研究 Fernanda Morales-BersteinAna Gonçalves-SoaresMaria-Carolina Borges Research 14 January 2026 Article: 2 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与管理 Prevalence of use and interest in using glucagon-like peptide-1 receptor agonists for weight loss: a population study in Great Britain 胰高血糖素样肽-1受体激动剂用于减重的使用率及使用意愿：一项针对英国人群的研究 Sarah E. JacksonJamie BrownLion Shahab Research 08 January 2026 Article: 1 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响