A Randomized, Double-blind, Placebo-Controlled, Phase 3 Study of Olezarsen (ISIS 678354) in Patients With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), or With Severe Hypertriglyceridemia

The purpose of the study is to evaluate the effect of olezarsen on percent change in fasting triglyceride (TG) levels compared to placebo in participants with hypertriglyceridemia and atherosclerotic cardiovascular disease, or with severe hypertriglyceridemia.

开始日期2022-11-21

申办/合作机构

Ionis Pharmaceuticals, Inc.

NCT05579860

/ Completed临床1期

A Single-Dose, Randomized, Open-Label, Two-Period Crossover, Bioequivalence Study Comparing Two Subcutaneous Formulations: Vial and Autoinjector (AI) With Olezarsen, at Two Dose Levels, in Healthy Adult Participants

The purpose of the study is to assess the bioequivalence of olezarsen between 2 subcutaneous (SC) formulations [(autoinjector (AI) and vial] at 2 dose levels in healthy adult participants.

开始日期2022-10-05

申办/合作机构

Ionis Pharmaceuticals, Inc.

NCT05552326

/ Completed临床3期

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients With Severe Hypertriglyceridemia

The purpose of this study is to evaluate the efficacy of olezarsen as compared to placebo on the percent change in fasting triglycerides (TG) from baseline.

开始日期2022-08-31

申办/合作机构

Ionis Pharmaceuticals, Inc.

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100 项与奥莱扎森相关的转化医学

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100 项与奥莱扎森相关的专利（医药）

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项与奥莱扎森相关的文献（医药）

2026-02-20·JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Approach to the Adult Patient with Chylomicronemia

Review

作者: Hegele, Robert A

Abstract:

Chylomicronemia, defined by fasting triglycerides ≥10 mmol/L (≥885 mg/dL), has diverse etiologies. When clinical features such as abdominal pain, lipemia retinalis, eruptive xanthomas, hepatosplenomegaly, pancreatitis, or visibly lipemic plasma accompany the biochemical disturbance, the condition is called chylomicronemia syndrome. Subtypes include rare monogenic familial chylomicronemia syndrome (FCS), the more common multifactorial chylomicronemia syndrome (MCS), autoimmune chylomicronemia, and lipodystrophy-associated chylomicronemia. Patients are at risk for acute pancreatitis and sometimes atherosclerotic cardiovascular disease. Accurate diagnosis includes medical history, physical exam, laboratory testing (including plasma apolipoprotein B and the ratio of triglyceride to total cholesterol), clinical scoring systems, as well as selective use of genetic testing when FCS is suspected. In adults, the overwhelming majority of patients with chylomicronemia have MCS and not FCS. Treatment centers on dietary fat restriction, total alcohol avoidance, management of secondary factors, and traditional triglyceride-lowering therapies such as fibrates and omega-3 fatty acids. Acute pancreatitis management requires stabilization, analgesia, supportive care, and preventive management of hypertriglyceridemia. Emerging RNA-based therapies targeting apolipoprotein C-III (eg, volanesorsen, olezarsen, and plozasiran) offer transformative potential for FCS and for some refractory patients with other chylomicronemia subtypes. A multidisciplinary approach—integrating clinical, biochemical, and genetic assessment—guides therapy and reduces pancreatitis risk.

2026-02-01·Journal of Clinical Lipidology

Olezarsen reduces all-cause health services utilization and improves the treatment experience of patients with familial chylomicronemia syndrome

Article

作者: Mejia Herrera, Catalina ; Tsimikas, Sotirios ; Baum, Seth J ; Ann, Quratul ; Vera-Llonch, Montserrat ; Stroes, Erik S G ; Sikora Kessler, Asia ; Paparrodopoulos, Spyros ; Xia, Shuting ; Alexander, Veronica J ; Karwatowska-Prokopczuk, Ewa

BACKGROUND:

Familial chylomicronemia syndrome (FCS) is a rare genetic disorder associated with extreme hypertriglyceridemia and high risk of acute pancreatitis. Olezarsen-an antisense oligonucleotide targeting hepatic apolipoprotein C3 (APOC3) messenger RNA-reduces triglycerides and may decrease pancreatitis risk. Olezarsen 80 mg once monthly is approved in the United States as an adjunct to diet to reduce triglycerides in adults with FCS.

OBJECTIVE:

To assess the effect of olezarsen on all-cause healthcare resource utilization (HCRU) and overall experience of patients with genetically identified FCS enrolled in the Balance trial (NCT04568434).

METHODS:

Prespecified exploratory endpoints included yearly all-cause hospitalization, total inpatient days, and emergency room visits for patients treated with olezarsen (80 or 50 mg) vs placebo, as well as Patient Global Impression of Change (PGIC). Ad hoc outcomes included length of hospital stay, intensive care unit (ICU) admissions, reasons for HCRU, and all-cause HCRU according to patients' history of acute pancreatitis and for individual olezarsen doses vs placebo.

RESULTS:

Treatment with olezarsen vs placebo for 1 year was associated with an 84% reduction in all-cause hospitalizations (mean rate ratio [95% CI], 0.16 [0.05, 0.50]), 6.3 fewer total inpatient days (95% CI, -11.09, -1.53), better PGIC scores, shorter length of stay, and numerically fewer ICU admissions. Acute pancreatitis was the most frequent cause of hospitalization. Reduction in all-cause inpatient service utilization was consistent for individual dose groups and in patients with a history of acute pancreatitis.

CONCLUSION:

In the Balance study, olezarsen reduced all-cause inpatient service utilization and improved the experience of patients with FCS.

2026-01-29·NEW ENGLAND JOURNAL OF MEDICINE

Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk

Article

作者: Cohen, Hofit ; Nicholls, Stephen J. ; Kiss, Robert Gabor ; Bergmark, Brian A. ; Goudev, Assen ; Tsimikas, Sotirios ; Zimerman, Andre ; Xia, Shuting ; Murphy, Sabina A. ; Blom, Dirk ; Sabatine, Marc S. ; Kang, Yu Mi ; Goldberg, Anne C. ; Weinland, Julia ; Moura, Filipe A. ; Li, Dan ; Moulin, Philippe ; Gaudet, Daniel ; Vrablik, Michal ; Alexander, Veronica J. ; Marston, Nicholas A. ; Stroes, Erik S.G. ; Goodrich, Erica L. ; Zhang, Shuanglu ; Charng, Min-Ji ; Giugliano, Robert P. ; Nordestgaard, Børge G. ; Banach, Maciej ; Badimon, Lina ; Prohaska, Thomas A. ; Waldman, Elaine

BACKGROUND:

Patients with severe hypertriglyceridemia have an increased risk of acute pancreatitis. The efficacy and safety of olezarsen, an antisense oligonucleotide targeting apolipoprotein C-III messenger RNA, have not been established in this population.

METHODS:

We conducted two double-blind, randomized, placebo-controlled trials (CORE-TIMI 72a and CORE2-TIMI 72b). Patients with severe hypertriglyceridemia were assigned in a 1:1:1 ratio to receive olezarsen at a dose of 50 mg, olezarsen at a dose of 80 mg, or placebo monthly for 12 months. The primary outcome was the percent change in the triglyceride level at 6 months, reported as the difference between each olezarsen dose group and the placebo group (placebo-adjusted change). Secondary lipid outcomes included the percent change in the triglyceride level at 12 months and in apolipoprotein C-III, remnant cholesterol, and non-high-density lipoprotein (non-HDL) cholesterol at 6 months and 12 months. Acute pancreatitis events were assessed across both trials.

RESULTS:

A total of 1061 patients were included in the primary analysis (617 in the CORE-TIMI 72a trial and 444 in the CORE2-TIMI 72b trial). At 6 months, the placebo-adjusted least-squares mean change from baseline in the triglyceride level was -62.9 percentage points in the olezarsen 50-mg group and -72.2 percentage points in the olezarsen 80-mg group in the CORE-TIMI 72a trial and was -49.2 percentage points in the olezarsen 50-mg group and -54.5 percentage points in the olezarsen 80-mg group in the CORE2-TIMI 72b trial (P<0.001 for all comparisons of olezarsen with placebo). Decreases in the levels of triglycerides, apolipoprotein C-III, remnant cholesterol, and non-HDL cholesterol were greater with olezarsen than with placebo (P<0.001 for all comparisons). The incidence of acute pancreatitis was lower with olezarsen than with placebo (mean rate ratio, 0.15; 95% confidence interval, 0.05 to 0.40; P<0.001). The incidence of any adverse events appeared to be similar across trial groups. Elevations in liver-enzyme levels and thrombocytopenia (platelet count, <100,000 per microliter) were more common with the 80-mg dose of olezarsen, and a dose-dependent increase in the hepatic fat fraction was noted.

CONCLUSIONS:

Among patients with severe hypertriglyceridemia, treatment with olezarsen led to a significantly greater reduction in the triglyceride level at 6 months and in the incidence of acute pancreatitis than placebo. (Funded by Ionis Pharmaceuticals; CORE-TIMI 72a and CORE2-TIMI 72b ClinicalTrials.gov numbers, NCT05079919 and NCT05552326.).

315

项与奥莱扎森相关的新闻（医药）

2026-03-31

·PRNewswire

EMA validates indication extension application for Tryngolza® (olezarsen) for the treatment of severe hypertriglyceridemia (sHTG)

March 30, 2026 -- Sobi® (STO: SOBI) today announced that the European Medicines Agency (EMA) has validated an indication extension application for Tryngolza® (olezarsen) for the treatment of adult patients with severe hypertriglyceridemia (sHTG) ≥880 mg/dL (≥10 mmol/L). Patients with elevated triglyceride levels have substantially higher risks of all-cause mortality, atherosclerotic cardiovascular events, and acute pancreatitis[1]. The submission is supported by results from the pivotal Phase 3 CORE and CORE2 studies, which were published in the New England Journal of Medicine in 2025[2]. "Tryngolza is the only pharmacological therapy to demonstrate a reduction in the risk of acute pancreatitis in patients with severe hypertriglyceridemia. If approved, it could offer an important therapeutic option to help prevent this life-threatening condition, which can place a significant burden on patients due to frequent hospitalisations, intensive treatment, persistent symptoms and reduced quality of life," said Lydia Abad-Franch, MD, Head of R&D and Medical Affairs and Chief Medical Officer at Sobi. "Sobi's marketing authorisation application reflects the growing body of clinical evidence supporting Tryngolza and our commitment to improving treatment options for people living with sHTG." Olezarsen is developed by Ionis Pharmaceuticals. Sobi and Ionis entered into a licence agreement under which Sobi has exclusive rights to commercialise Tryngolza in ex-U.S. geographies except Canada and China. Tryngolza® (olezarsen) was approved in the European Union in September 2025 as an adjunct to diet for the treatment of adult patients with genetically confirmed familial chylomicronemia syndrome (FCS). Severe hypertriglyceridemia (sHTG) is defined by severely high triglycerides ≥500 mg/dL (≥5,65 mmol/L) and triglyceride levels ≥880 mg/dL (≥10 mmol/L) are often associated with the increased accumulation of chylomicrons in the blood and with an increased risk of acute pancreatitis and other morbidities. Considered a medical emergency, acute pancreatitis causes debilitating abdominal pain that often requires prolonged hospitalisation, can lead to permanent organ damage and can become life-threatening. Preventing the first attack is key. Current standard of care therapies for sHTG and lifestyle modifications (such as diet and exercise) do not sufficiently or consistently lower triglyceride levels or reduce the risks in all patients. Approximately 2 million people are living with sHTG in the EU5, including approximately 700,000 with TG levels ≥880 mg/dL (≥10 mmol/L). CORE (NCT05079919; n=617) and CORE2 (NCT05552326; n=446), conducted with The TIMI Study Group, are Phase 3 global, multicentre, randomised, double-blind, placebo-controlled trials investigating the safety and efficacy of olezarsen for severe hypertriglyceridemia (sHTG). Participants aged 18 and older with triglyceride levels ≥500 mg/dL (≥5.65 mmol/L) were enrolled. Participants were required to be on standard of care therapies for elevated triglycerides. At baseline, 43% of participants had fasting triglycerides ≥880 mg/dL (≥10 mmol/L). Participants were randomised to receive 50 mg or 80 mg of olezarsen or placebo every 4 weeks via subcutaneous injection for 12 months. The primary endpoint was the percent change from baseline in fasting triglycerides at six months compared to placebo. Olezarsen is an RNA-targeted medicine being evaluated for the treatment of sHTG. Olezarsen is designed to lower the body's production of apoC-III, a protein produced in the liver that regulates triglyceride metabolism in the blood. Olezarsen is approved in the U.S., Canada, and the European Union as TRYNGOLZA® for adults with familial chylomicronemia syndrome (FCS). Sobi® is a global biopharma company unlocking the potential of breakthrough innovations, transforming everyday life for people living with rare diseases. Sobi has approximately 1,900 employees across Europe, North America, the Middle East, Asia and Australia. In 2025 revenue amounted to SEK 28 billion. Sobi's share (STO:SOBI) is listed on Nasdaq Stockholm. [1] Ginsberg et al. Eur Heart J. 2021;42(47):4791-4806. [2] Marston, Nicholas A et al. "Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk." The New England journal of medicine vol. 394,5 (2026): 429-441. doi:10.1056/NEJMoa2512761 The content above comes from the network. if any infringement, please contact us to modify.

引进/卖出上市批准临床结果

2026-03-31

·CVDAILY

全球糖尿病速递（第090期）｜GLP-1 RA与减重手术、咖啡摄入时间与胰岛素抵抗、VO2peak决定因素、司美格鲁肽1...

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放截至03月31日15点59分，近期共有 497 本期刊发布了 1131 篇文章，其中糖尿病相关的文章共 339 篇，覆盖 32 个领域的内容。中国专家参与发表的文章有 86 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。今日头条 Headlines 01 EHJ-QCCO IF: 04.600 GLP-1受体激动剂与减重手术在患有肥厚型心肌病的肥胖患者中的结局比较：一项多中心倾向匹配分析 Mahmoud, Ahmed K, Awad, Kamal, Sheashaa, Hesham, Kandil, Omneya, Farina, Juan M, Ibrahim, Ramzi, etc. 一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。一项多中心倾向匹配分析对比了GLP-1受体激动剂（GLP-1 RA）与减重手术（BS）在患有肥厚型心肌病（HCM）的肥胖患者中的结局差异。研究纳入5002例符合条件的患者，经1:1倾向匹配后每组955例，平均年龄54±13岁，70%为女性，基线体重指数（BMI）均为40.0 kg/m²。研究将患者分为两组，一组为从未接受过减重手术的GLP-1 RA使用者，另一组为从未使用过GLP-1 RA的减重手术患者，通过倾向匹配平衡人口统计学特征、合并症及用药情况。随访24个月，评估全因死亡率、急性心力衰竭（HF）住院、心律失常、BMI变化及心血管症状等指标。结果显示，与减重手术相比，GLP-1 RA治疗在全因死亡率和心力衰竭事件方面表现更优。具体数据显示，GLP-1 RA组全因死亡率为2.0%，显著低于BS组的4.4%（HR=0.46，95%CI 0.27-0.80，P=0.004）；HF住院率GLP-1 RA组为8.7%，低于BS组的14.0%（HR=0.60，95%CI 0.46-0.79，P<0.001）。此外，GLP-1 RA组复合心血管结局发生率（10.7%）显著低于BS组（17.2%）（HR=0.60，95%CI 0.47-0.77，P<0.001）。 BMI变化方面，BS组平均降低4.0 kg/m²，高于GLP-1 RA组的2.6 kg/m²（P<0.001）。但两组在心律失常和心血管症状发生率上无显著差异。研究结论指出，在患有肥厚型心肌病的肥胖患者中，GLP-1 RA治疗与减重手术相比，全因死亡率和心力衰竭事件风险更低。未来研究需进一步验证这一发现。本文由韩玉莲编辑扫描二维码查看源文 EHJ-QCCO | Ahead of Print. 10.1093/ehjqcco/qcag051 02 Frontiers in immunology IF: 05.900 早晨咖啡摄入时间及其与胰岛素抵抗的关联：来自人类和动物实验的证据 Liu, Peiyan, Yao, Guixiang, Wu, Yixia, Zhou, Qi, etc. 近日，一项发表于Frontiers in Immunology的研究通过对美国国家健康与营养检查调查（NHANES）2005-2018年数据的二次分析及小鼠实验，揭示了咖啡摄入时间对胰岛素抵抗的关键影响。研究发现，早晨集中摄入咖啡（如上午4:00-11:59 AM）与胰岛素抵抗（通过甘油三酯-葡萄糖指数（TyG）、代谢性胰岛素抵抗指数（METS-IR）、甘油三酯/高密度脂蛋白胆固醇比值（TG/HDL-C）三个指标验证）呈线性负相关，而全天分散摄入咖啡则呈J形关联。进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。进一步动物实验表明，早晨咖啡摄入可降低高脂饮食诱导的小鼠血糖、胰岛素水平，增强葡萄糖耐受性，并通过抑制促炎因子（如IL-1β、IL-6）改善代谢健康。此外，研究证实炎症因子（白细胞计数、中性粒细胞/淋巴细胞比值）在该关联中起部分中介作用。这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。这一发现提示，咖啡摄入时间可能是影响代谢健康的关键因素，早晨集中摄入咖啡或为改善胰岛素抵抗的潜在策略。本文由韩玉莲编辑扫描二维码查看源文 Frontiers in immunology | Volume 17, Issue 10.3389/fimmu.2026.1775412 03 EJPC IF: 07.500 2型糖尿病成人对有氧运动训练的最大摄氧量峰值（VO2peak）反应性决定因素：PROTECTION研究 Michielsen, Matthijs, Gojevic, Tin, Bekhuis, Youri, Claes, Jomme, Machado, Felipe, Claessen, Guido, etc. European Journal of Preventive Cardiology在线发表的PROTECTION研究表明，26周中等强度骑行计划可显著改善2型糖尿病（T2D）成人的心肺功能（最大摄氧量峰值VO2peak），但个体反应差异显著，脂肪质量和胰岛素抵抗是关键预测因素。该研究纳入108例T2D成人参与26周监督下的中等强度骑行训练（3次/周），最终88例完成全程（平均年龄59.8±9.2岁，64%为男性）。结果显示，VO2peak平均提升3.6±2.5 mL/kg/min（增幅17%）。分组分析发现，与无反应者相比，高反应者的脂肪质量更低、胰岛素抵抗更小，且基线体能（心肺功能）也较低。研究通过单变量和多变量LASSO回归分析，识别出影响VO2peak变化的关键因素：女性性别、吸烟、人体测量指标（如体重/体脂）、胰岛素抵抗及β受体阻滞剂或GLP-1受体激动剂的使用与VO2peak改善负相关；而肺功能、肌肉力量和血红蛋白水平与之正相关。多变量模型进一步证实，脂肪质量（%）和胰岛素抵抗是决定VO2peak反应性的核心基线因素。研究结论指出，26周中等强度骑行能有效提升T2D成人的心肺功能，但个体反应差异较大。建议在糖尿病（前期）诊断后尽早开展运动干预，并结合改善身体成分的措施，以增强心肺功能的提升效果。本文由韩玉莲编辑扫描二维码查看源文 EJPC | Ahead of Print. 10.1093/eurjpc/zwag150 04 Diabetes, obesity & metabolism IF: 05.700 司美格鲁肽1.7 mg用于青少年肥胖治疗的有效性、安全性和药代动力学：基于模型的药物开发方法 Strathe, Anders, Bomberg, Eric M, Jensch, Garrit, Kildegaard, Jonas, Harder-Lauridsen, Nina M, Weghuber, Daniel, etc. 本研究采用基于模型的药物开发方法（MIDD），结合青少年STEP TEENS 3期研究（N=201）和成人STEP研究（约3100名参与者）数据，分析1.7 mg司美格鲁肽在青少年肥胖治疗中的有效性、安全性和药代动力学特征。研究目的是探索青少年肥胖治疗的低剂量选择，评估1.7 mg剂量与成人及2.4 mg剂量的比较效果。方法上，研究整合了不同剂量（0.25-2.4 mg）的浓度-时间曲线模型，通过模拟分析青少年与成人的药代动力学（PK）参数差异，同时计算BMI变化百分比，估算达成≥5%、≥10%、≥15% BMI降低的比例，并根据暴露量预测胃肠道不良事件（AE）发生率。主要协变量分析显示体重是影响司美格鲁肽暴露量的关键因素。结果显示，青少年与成人在68周内的司美格鲁肽浓度模拟值相似，表明青少年无需调整剂量即可维持稳定暴露水平。1.7 mg剂量组青少年的平均BMI变化为-15.2%，与2.4mg剂量组（-17.4%）相当，且显著优于安慰剂（P<0.01）。预设BMI降低阈值（≥5%、≥10%、≥15%）的达成比例在青少年、成人及不同剂量组间均无显著差异，胃肠道不良事件发生率也与剂量和人群特征无关。该研究证实，药代动力学/药效学（PK/PD）和安全性模型证实1.7 mg司美格鲁肽在青少年中具有与成人及2.4m g剂量相当的暴露量、耐受性及BMI降低效果，这些结果支持2024年11月Wegovy标签批准1.7 mg剂量用于≥12岁青少年肥胖治疗，无需额外开展青少年1.7 mg安慰剂对照试验。本文由韩玉莲编辑扫描二维码查看源文 Diabetes, obesity & metabolism | Ahead of Print. 10.1111/dom.70678 中国发表（86） China Eur J Med Chem IF: 05.900Ahead of Print.No.01Synthesis, and pharmacological evaluation of iminoguanidine derivatives: Identification of FuBIG showing protective effects against diabetic neuroinflammation with a favorable lactate metabolism profile咪唑胍衍生物的合成及药理学评价：具有良好乳酸代谢谱的FuBIG对糖尿病神经炎症的保护作用DOI: 10.1016/j.ejmech.2026.118792 Br J Clin Pharmacol IF: 03.000Ahead of Print.No.02Comment on 'Renoprotective effects of dapagliflozin in diabetic patients with chronic kidney disease: A retrospective observational study'评论《达格列净对慢性肾脏病糖尿病患者的肾脏保护作用：一项回顾性观察研究》DOI: 10.1002/bcp.70546 Renal failure IF: 03.000Volume 48, Issue 1No.03Hirsutine mitigates high glucose-induced cell injury via autophagy activation and NRF2/GPX4-mediated ferroptosis inhibition汉防己甲素通过激活自噬和NRF2/GPX4介导的铁死亡抑制减轻高糖诱导的细胞损伤DOI: 10.1080/0886022X.2026.2637325 Scientific reports IF: 03.900Ahead of Print.No.04Non-linear associations between red blood cell distribution width/serum albumin ratio with diabetic kidney disease: results from two nationwide studies in the United States and China红细胞分布宽度/血清白蛋白比率与糖尿病肾病的非线性关联：中美两项全国性研究结果DOI: 10.1038/s41598-026-45999-9 Renal failure IF: 03.000Volume 48, Issue 1No.05ADAMTS13 ameliorates diabetic nephropathy by Nrf2/GPX4/eNOS signaling pathwayADAMTS13通过Nrf2/GPX4/eNOS信号通路改善糖尿病肾病DOI: 10.1080/0886022X.2026.2646089 Cellular signalling IF: 03.700Ahead of Print.No.06E3 ubiquitin ligases and deubiquitinases: Promising therapeutic targets for diabetic kidney diseaseE3泛素连接酶和去泛素化酶：糖尿病肾病的潜在治疗靶点DOI: 10.1016/j.cellsig.2026.112513 Int J Nurs Pract IF: 02.000Volume 32, Issue 2No.07Prevalence of Subthreshold Depression in Patients With Diabetes Mellitus: Systematic Review and Meta-Analysis糖尿病患者阈下抑郁的患病率：系统综述与荟萃分析DOI: 10.1111/ijn.70135 International journal of obesity IF: 03.800Ahead of Print.No.08Genetic evidence for the association between schizophrenia and obesity精神分裂症与肥胖关联的遗传证据DOI: 10.1038/s41366-026-02059-6 Zhonghua yixue zazhiVolume 106, Issue 12No.09[Gender differences in comorbidity characteristics among patients with sudden sensorineural hearing loss]突发性神经性耳聋患者合并症特征的性别差异DOI: 10.3760/cma.j.cn112137-20251128-03115 Scientific reports IF: 03.900Ahead of Print.No.10The association of TyG-BMI with MAFLD and liver fibrosis: a cross-sectional study甘油三酯-血糖-体重指数（TyG-BMI）与代谢相关脂肪肝疾病（MAFLD）及肝纤维化的关联：一项横断面研究DOI: 10.1038/s41598-026-46378-0 Acta pharmacologica Sinica IF: 08.400Ahead of Print.No.11Transcutaneous allicin oleogel restores energy homeostasis for obesity treatment经皮大蒜素油凝胶恢复能量稳态以治疗肥胖DOI: 10.1038/s41401-026-01768-y J Int Med Res IF: 01.500Volume 54, Issue 3No.12Serum high-density lipoprotein partially mediates the inverted L-shaped association between estimated glucose disposal rate and risk of kidney stones: A cross-sectional study from National Health and Nutrition Examination Survey血清高密度脂蛋白部分介导估计葡萄糖利用率与肾结石风险的倒L形关联：来自美国国家健康与营养检查调查的横断面研究DOI: 10.1177/03000605261431933 PloS one IF: 02.600Volume 21, Issue 3No.13Osteoarthritis in older adults: A global health challenge and the role of high BMI in shaping disease trends老年人骨关节炎：全球健康挑战及高体重指数对疾病趋势的影响DOI: 10.1371/journal.pone.0344284 Circulation IF: 38.600Volume 153, Issue 13No.14Response by Gao et al to Letter Regarding Article, "G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice"高等人对《G蛋白偶联受体激酶3通过直接磷酸化人及小鼠大麻素受体2加重糖尿病心脏损伤》一文相关来信的回应DOI: 10.1161/CIRCULATIONAHA.125.079055 Gut : IF: 25.800Volume 75, Issue 3No.15Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes两步临床护理路径预测2型糖尿病患者代谢功能障碍相关脂肪性肝病的晚期肝纤维化及长期结局DOI: 10.1136/gutjnl-2025-337506 International immunopharmacology IF: 04.700Ahead of Print.No.16The TGFB1-Wnt/β-catenin axis programs a neuroprotective IGF1(+) microglial state during epileptogenesisTGFB1-Wnt/β-catenin轴在癫痫发生过程中编程神经保护性IGF1(+)小胶质细胞状态DOI: 10.1016/j.intimp.2026.116579 Circulation IF: 38.600Volume 153, Issue 13No.17Letter by Wu et al Regarding Article, "G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice"G蛋白偶联受体激酶3通过直接磷酸化人类和小鼠的大麻素受体2加重糖尿病心脏损伤DOI: 10.1161/CIRCULATIONAHA.125.077325 PeerJ IF: 02.400Volume 14, Issue No.18Impact of EV administration on murine hematology and metabolism小鼠中同源和异源细胞外囊泡给药对代谢和免疫反应的影响DOI: 10.7717/peerj.20952 J Hepatocell Carcinoma IF: 03.400Volume 13, Issue No.19"WBC-HBP Dissociation" Unveils Occult Xanthogranulomatous Inflammation Mimicking Hepatocellular Carcinoma in Diabetic Patients白细胞-肝素结合蛋白解离现象揭示糖尿病患者中类似肝细胞癌的隐匿性黄肉芽肿性炎症DOI: 10.2147/JHC.S596910 Front Cell Dev Biol IF: 04.300Volume 14, Issue No.20A metabolic-inflammatory burden phenotype associated with urinary glucose in colorectal cancer尿糖作为结直肠癌风险分层的代谢-炎症负担标志物DOI: 10.3389/fcell.2026.1797508 Clin Cosmet Investig Dent IF: 01.800Volume 18, Issue No.21Periodontitis Phenotypes and Treatment Outcomes Following Combined Periodontal and Orthodontic Therapy: A Cohort Study联合牙周和正畸治疗后牙周炎表型及治疗效果：一项队列研究DOI: 10.2147/CCIDE.S592473 Infection and drug resistance IF: 02.900Volume 19, Issue No.22Sepsis Caused by Clostridium Perfringens in an Elderly Female Patient with Breast Cancer: A Case Report恶性乳腺癌患者中的产气荚膜梭菌败血症：病例报告及文献综述DOI: 10.2147/IDR.S560686 Materials today bio IF: 10.200Volume 38, Issue No.23Procyanidin capsules attenuate PI3K/AKT-mediated mitochondrial dysfunction and accelerate skin wound healing in diabetic mice原花青素胶囊通过激活PI3K/AKT信号通路促进糖尿病皮肤伤口愈合DOI: 10.1016/j.mtbio.2026.103029 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.24Effectiveness and safety of Chinese traditional medicine Ulcer Ointment for skin ulcers: a systematic review and meta-analysis of randomized controlled trials溃疡软膏（UO）治疗皮肤溃疡的随机对照试验荟萃分析DOI: 10.3389/fphar.2026.1764562 Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.25Atractylenolide III improves ovarian dysfunction and endometrial receptivity in a PCOS rat model by regulating Cybb-mediated oxidative stress苍术酮III通过调节Cybb介导的氧化应激改善PCOS大鼠模型中的卵巢功能障碍和子宫内膜容受性DOI: 10.1007/s00210-026-05264-2 Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.26Exploiting eNOS activation to achieve tumor vascular normalization via endothelial transcytosis of lipid nanoparticles利用脂质纳米颗粒经内皮细胞胞吞转运激活eNOS以实现肿瘤血管正常化DOI: 10.1016/j.apsb.2025.11.040 Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.27Single-cell RNA sequencing-guided drug discovery to alleviate radiotherapy-induced esophageal toxicity单细胞RNA测序指导药物发现以减轻放疗诱导的食管毒性DOI: 10.1016/j.apsb.2025.12.038 Frontiers in reproductive health IF: 02.900Volume 7, Issue No.28The role and underlying mechanisms of Qi Gong Wan in enhancing the endometrial receptivity of a rat model with polycystic ovary syndrome七公丸（QGW）对多囊卵巢综合征诱导胰岛素抵抗（PCOS-IR）大鼠模型子宫内膜容受性的影响DOI: 10.3389/frph.2025.1733583 ACS Appl Mater Interfaces IF: 08.200Ahead of Print.No.29Injectable Dual-Cross-Linked Hydrogels Enabling Sequential Drug Release for Synergistic Periodontitis Therapy可注射双交联水凝胶实现顺序药物释放用于协同牙周炎治疗DOI: 10.1021/acsami.6c01751 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.30Impaired awareness of hypoglycemia: can structured education address this persistent challenge?低血糖感知障碍：结构化教育能否解决这一长期挑战？DOI: 10.3389/fendo.2026.1722045 iScience IF: 04.100Volume 29, Issue 4No.31An implantable dual-chamber capsule with three release modes for site-specific delivery and enhanced therapeutic efficacy具有三种释放模式的可植入双腔胶囊，用于定点给药并增强治疗有效性DOI: 10.1016/j.isci.2026.115099 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.32Molecular mechanisms and preclinical evidence of natural products in diabetic osteoporosis: a review天然产物作为糖尿病性骨质疏松症的多靶点调节剂：一篇叙事性综述DOI: 10.3389/fendo.2026.1793925 Frontiers in public health IF: 03.400Volume 14, Issue No.33Confronting the economic burden of diabetes: Can TCM DRG payment reform in China offer a viable solution? Insights from empirical research in Western ChinaDRG支付改革是否降低了中西医结合医院糖尿病患者的住院费用？来自中国西部一项间断时间序列分析的证据DOI: 10.3389/fpubh.2026.1792742 Int J Nanomedicine IF: 06.500Volume 21, Issue No.34Antimicrobial Hydrogel for Diabetic Wound Treatment用于糖尿病伤口治疗的抗菌水凝胶DOI: 10.2147/IJN.S572181 FCVM IF: 02.900Volume 13, Issue No.35Mitochondrial dysfunction in diabetic cardiomyopathy: a review of pathogenic mechanisms and therapeutic strategies糖尿病心肌病中的线粒体功能障碍：病理生理学、治疗策略及未来方向的综合综述DOI: 10.3389/fcvm.2026.1751243 Aging cell IF: 07.100Volume 25, Issue 4No.36Pck1 Deficiency Drives Mitochondrial Dysfunction and Cellular Senescence in AdipocytesPck1缺陷驱动脂肪细胞线粒体功能障碍和细胞衰老DOI: 10.1111/acel.70462 Gut microbes reportsVolume 2, Issue 1No.37Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice长双歧杆菌缓解高脂饮食诱导的小鼠肥胖并保护肠上皮屏障DOI: 10.1080/29933935.2025.2459599 Bioactive materials IF: 20.300Volume 62, Issue No.38Nanomaterial-driven modulation of lipid metabolism: Novel strategies toward precision obesity treatment纳米材料驱动的脂质代谢调节：精准肥胖治疗的新策略DOI: 10.1016/j.bioactmat.2026.02.057 Clinical interventions in aging IF: 03.700Volume 21, Issue No.39Dynamic versus Static Metabolic Models for Predicting ECG-Defined Cardiovascular Risk in Elderly MAFLD: A Three-Year Cohort Study动态与静态代谢模型预测老年MAFLD患者心电图定义的心血管风险：一项为期三年的队列研究DOI: 10.2147/CIA.S567520 Frontiers in nutrition IF: 05.100Volume 13, Issue No.40Gut microbiota mediates the anti-obesity effects of Gnaphalium affine methanol extract in HFD-induced obesity香青兰提取物（GAE）通过调节肠道菌群和增强代谢功能减轻高脂饮食（HFD）诱导的肥胖DOI: 10.3389/fnut.2026.1779459 Frontiers in public health IF: 03.400Volume 14, Issue No.41Prevalence and influencing factors of functional constipation in Chinese children and adolescents: a systematic review and meta-analysis中国儿童青少年功能性便秘的患病率及影响因素：一项系统综述与荟萃分析DOI: 10.3389/fpubh.2026.1776863 Frontiers in medicine IF: 03.000Volume 13, Issue No.42Subchondral H-type blood vessel formation aggravates articular cartilage degeneration through LEP-LEPR axis瘦素/瘦素受体信号通路调控骨关节炎中软骨下骨H型血管生成和关节软骨降解DOI: 10.3389/fmed.2026.1751127 Frontiers in immunology IF: 05.900Volume 17, Issue No.43Unveiling the immune microenvironment in diabetic nephropathy: from mechanisms to therapeutics糖尿病肾病中的肾脏免疫微环境：机制、调控及治疗靶点DOI: 10.3389/fimmu.2026.1750484 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.44Assessing the association of FIB-4 index with diabetic kidney disease in patients with diabetes mellitus: a cross-sectional and retrospective study utilizing NHANES and clinical dataFib-4指数作为2型糖尿病患者糖尿病肾病进展的危险因素DOI: 10.3389/fendo.2026.1800874 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.45Unveiling the TrkA-p35/CDK5 axis: a novel therapeutic target in diabetic kidney diseaseTrkA抑制剂通过ERK/EGR1/p35/CDK5信号轴减轻糖尿病肾病中的足细胞损伤DOI: 10.3389/fendo.2026.1791283 iScience IF: 04.100Volume 29, Issue 4No.46Multidimensional analysis of depression and diabetic kidney disease using GBD, NHANES, and MR抑郁与糖尿病肾病：全球负担、观察性关联及遗传因果关系的多层级分析DOI: 10.1016/j.isci.2026.115265 Journal of inflammation research IF: 04.100Volume 19, Issue No.47SIRT2 in Diabetic Kidney Disease: Multifaceted Regulatory Roles and Therapeutic ChallengesSIRT2在糖尿病肾病中的作用机制、调控网络及治疗策略DOI: 10.2147/JIR.S588949 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.48Metabolic Crosstalk in Diabetic Kidney Disease: Synergistic Effects of Glucotoxicity and Lipotoxicity糖尿病肾病中的代谢串扰：糖毒性与脂毒性的协同作用DOI: 10.2147/DMSO.S580866 Digital health IF: 03.300Volume 12, Issue No.49Diabetic peripheral neuropathy identification using enface optical coherence tomography and multi-head attention deep learning algorithm使用多头部注意力深度学习的无创性糖尿病周围神经病变识别DOI: 10.1177/20552076261436274 Naunyn Schmiedebergs Arch Pharmacol IF: 03.100Ahead of Print.No.50Temsirolimus safety evaluation: real-world adverse event analysis from the FDA adverse event reporting system database西罗莫司安全评估：来自FDA不良事件报告系统数据库的真实世界不良事件分析DOI: 10.1007/s00210-026-05233-9 Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.51Identification of a small-molecule targeting PLAGL2 DNA-binding domain inhibits extracellular matrix formation and enhances lenvatinib sensitivity in hepatocellular carcinoma靶向PLAGL2 DNA结合域的小分子抑制细胞外基质形成并增强肝细胞癌中仑法替尼敏感性DOI: 10.1016/j.apsb.2025.12.016 Frontiers in nutrition IF: 05.100Volume 13, Issue No.52One-month early time-restricted eating enhances cognition via white matter-cortical pathways in males with metabolic syndrome: evidence from TBSS and SBM analyses1个月早期限时饮食改善代谢综合征男性的代谢健康、认知功能及脑结构：基于丘脑-皮质通路视角DOI: 10.3389/fnut.2026.1753462 Frontiers in nutrition IF: 05.100Volume 13, Issue No.53Vitamin D and exercise in obesity: a neurovascular-muscle axis维生素D与运动在肥胖中的作用：神经血管-肌肉轴DOI: 10.3389/fnut.2026.1750915 Drug Des Devel Ther IF: 05.100Volume 20, Issue No.54Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential苦参碱在肝脏疾病中的作用机制与治疗潜力DOI: 10.2147/DDDT.S577265 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.55Cardiovascular Outcomes and Safety of GLP-1 Receptor Agonists in Elderly Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis2型糖尿病老年患者中胰高血糖素样肽-1受体激动剂的心血管结局和安全性：一项系统综述和荟萃分析DOI: 10.2147/DMSO.S580095 Frontiers in immunology IF: 05.900Volume 17, Issue No.56Case report: Thymoma-associated GAD65 autoimmunity: a unifying mechanism for multi-organ injury involving nervous, endocrine, and renal systems胸腺瘤相关GAD65自身免疫：一种涉及神经、内分泌和肾脏系统多器官损伤的统一机制DOI: 10.3389/fimmu.2026.1790631 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.57Children with craniopharyngioma resection had better response to recombinant human growth hormone therapy than those with idiopathic short stature儿童颅咽管瘤患者的生长激素治疗：与特发性身材矮小的比较研究DOI: 10.3389/fendo.2026.1768846 Drug Des Devel Ther IF: 05.100Volume 20, Issue No.58A Comprehensive Review on the Cardioprotective and Nephroprotective Effects of Semaglutide, and Its Therapeutic Efficacy and Mechanisms in Cardiorenal Syndrome司美格鲁肽在心肾综合征中的应用：有效性、机制及临床证据综合综述DOI: 10.2147/DDDT.S581491 Drug Des Devel Ther IF: 05.100Volume 20, Issue No.59Potential Antiarrhythmic Mechanisms of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs)胰高血糖素样肽-1受体激动剂（GLP-1RAs）与心脏心律失常：作用机制与治疗潜力DOI: 10.2147/DDDT.S579419 Front Cell Dev Biol IF: 04.300Volume 14, Issue No.60Identification of mitochondria-related key genes in type 2 diabetes mellitus and elucidation of the Zhimu-Huangbai herb Pair's mechanism: an integrated approach of bioinformatics, machine learning, and experimental validation知母-黄柏对2型糖尿病的作用：通过线粒体功能多靶点调节的分子机制DOI: 10.3389/fcell.2026.1763178 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.61Plasma R-spondin 2 levels are associated with the progression of diabetic kidney disease血浆R-脊椎蛋白2水平与糖尿病肾病的进展相关DOI: 10.3389/fendo.2026.1787296 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.62Association Between Thyroid Hormone Sensitivity and Peripheral Arterial Disease in Euthyroid Patients with Type 2 Diabetes甲状腺功能正常的2型糖尿病患者中甲状腺激素敏感性与外周动脉疾病的关系DOI: 10.2147/DMSO.S571291 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.63Thyroid Hormone Indices and Histopathological Severity of Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes: A Biopsy-Based Cross-Sectional Study甲状腺功能正常的2型糖尿病患者中甲状腺激素指标与糖尿病肾病组织病理学严重程度的关系：一项基于活检的横断面研究DOI: 10.2147/DMSO.S589576 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.64Correlation Between the Thyroid Hormone Levels and Type 2 Diabetes Mellitus in Non-Alcoholic Fatty Liver Disease非酒精性脂肪肝患者中甲状腺激素水平与2型糖尿病的关系：聚焦游离三碘甲状腺原氨酸与游离甲状腺素比值DOI: 10.2147/DMSO.S577491 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.65Emulating the LEADER trial in China: a regulatory science case study on non-interventional research在中国模拟LEADER试验：一项关于非干预性研究的监管科学案例研究DOI: 10.3389/fendo.2026.1777954 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.66Beyond the triglyceride-glucose index, the cholesterol- high-density lipoprotein -glucose index as a superior predictor for diabetes risk in patients with major adverse cardiovascular events: dual evidence from the CHARLS database and real-world data超越甘油三酯-葡萄糖指数，胆固醇-高密度脂蛋白-葡萄糖指数作为主要不良心血管事件患者糖尿病风险的更优预测指标：来自CHARLS数据库和真实世界数据的双重证据DOI: 10.3389/fendo.2026.1797342 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.67Analysis of the association between history of gestational diabetes mellitus and hypertensive disorders in a subsequent pregnancy: a retrospective cohort study妊娠期糖尿病（GDM）复发史与后续妊娠高血压疾病风险独立相关：一项大型回顾性队列研究DOI: 10.3389/fendo.2026.1736779 Frontiers in immunology IF: 05.900Volume 17, Issue No.68Timing of coffee consumption and insulin resistance: evidence from human and animal studies早晨咖啡摄入时间及其与胰岛素抵抗的关联：来自人类和动物实验的证据DOI: 10.3389/fimmu.2026.1775412 FCVM IF: 02.900Volume 13, Issue No.69From lipid dysbalance to cardiorenal decompensation: apoB/ApoA1 ratio is associated with acute cardiorenal injury in CAD patients载脂蛋白B/载脂蛋白A1比值与冠心病患者1型心肾综合征的关联DOI: 10.3389/fcvm.2026.1754713 Frontiers in oncology IF: 03.300Volume 16, Issue No.70The correlation between the triglyceride-glucose index and the odds of cervical cancer甘油三酯-葡萄糖指数与宫颈癌风险的关联研究DOI: 10.3389/fonc.2026.1766167 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.71Association between triglyceride glucose- systemic immune inflammation index and deep venous thrombosis in fresh fracture patient: a real-world retrospective study甘油三酯-葡萄糖系统性炎症指数(TyG-SII)与创伤性骨折患者术前深静脉血栓形成的单中心回顾性研究DOI: 10.3389/fendo.2026.1700809 Appl Biochem Biotechnol IF: 03.300Ahead of Print.No.72Metformin Induces Ferroptosis and Inhibits Malignant Progression in Diabetic Breast Cancer二甲双胍诱导铁死亡并抑制糖尿病乳腺癌的恶性进展DOI: 10.1007/s12010-026-05648-3 Appl Biochem Biotechnol IF: 03.300Ahead of Print.No.73BHMT Protects Against Diabetic Cataracts by Reducing Homocysteine and Counteracting Endoplasmic Reticulum Stress in Lens Epithelial CellsBHMT通过降低同型半胱氨酸并抵消晶状体上皮细胞中的内质网应激来预防糖尿病性白内障DOI: 10.1007/s12010-026-05678-x Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.74Polygenic and polysocial risk scores in post-type 2 diabetes dementia: Risk stratification and predictive modeling in the UK Biobank cohort多基因和多社会风险评分在2型糖尿病后痴呆中的应用：英国生物样本库队列中的风险分层与预测建模DOI: 10.1177/13872877261435200 Paediatr Perinat Epidemiol IF: 02.500Ahead of Print.No.75Haemoglobin Concentrations and Maternal and Neonatal Outcomes: Identifying Optimal Haemoglobin Ranges血红蛋白浓度与母婴结局：确定最佳血红蛋白范围DOI: 10.1111/ppe.70142 Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.76Liver-pancreas communication in disease and drug development代谢性疾病中的肝脏-胰腺轴：从机制到治疗DOI: 10.1016/j.apsb.2026.01.018 Acta pharmaceutica sinica B IF: 14.600Volume 16, Issue 3No.77Integrating Chinese medicine and intermittent fasting: A promising approach for treating diabetic vascular calcification整合中医药与间歇性禁食：治疗糖尿病血管钙化的有前景方法DOI: 10.1016/j.apsb.2026.01.004 Frontiers in immunology IF: 05.900Volume 17, Issue No.78Transcending risk factors: the implications of redefining diabetes as an immunometabolic disease for infectious disease studies超越风险因素：将糖尿病重新定义为免疫代谢疾病对传染病研究的意义DOI: 10.3389/fimmu.2026.1794628 Bioactive materials IF: 20.300Volume 62, Issue No.79Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair智能响应水凝胶协同介导免疫重塑-抗菌-血管生成级联反应用于糖尿病足溃疡修复DOI: 10.1016/j.bioactmat.2026.03.034 Kidney diseases IF: 03.100Volume 12, Issue 1No.80Finerenone in Chinese Patients with Chronic Kidney Disease and Type 2 Diabetes: A FIDELITY Subgroup Analysis非奈利酮用于合并2型糖尿病的慢性肾脏病中国患者：FIDELITY亚组分析DOI: 10.1159/000550850 Crit Rev Food Sci Nutr IF: 08.800Ahead of Print.No.81Exercise-derived exosomes mediate crosstalk between skeletal muscle, adipose tissue, and bone: mechanisms of inter-organ communication and tissue adaptation运动来源外泌体介导骨骼肌、脂肪组织与骨间串扰：器官间通讯及组织适应机制DOI: 10.1080/10408398.2026.2646268 Journal of proteome research IF: 03.600Ahead of Print.No.82Proteome Profiling Reveals Inflammation and Fibrosis Biomarkers in Urinary Migrasomes of Patients with Diabetic Kidney Disease蛋白质组分析揭示糖尿病肾病患者尿迁移小体中的炎症和纤维化生物标志物DOI: 10.1021/acs.jproteome.5c01073 Journal of diabetes IF: 03.700Volume 18, Issue 4No.83Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy富氢透明质酸敷料通过促进线粒体自噬改善糖尿病足溃疡DOI: 10.1111/1753-0407.70209 Advanced healthcare materials IF: 09.600Ahead of Print.No.84Specific Nanozyme-Based Cascade Catalysis Hydrogel With Oxygen-Self-Supplying and ROS-Scavenging Capacity for Efficient Diabetic Wound Healing具有供氧和清除活性氧能力的特定纳米酶基级联催化水凝胶用于高效糖尿病伤口愈合DOI: 10.1002/adhm.202505890 Food & function IF: 05.400Ahead of Print.No.85Folic acid alleviates endothelial dysfunction caused by T2DM-induced ferroptosis by activating the SIRT6/NRF2/GPX4 signaling pathway叶酸通过激活SIRT6/NRF2/GPX4信号通路减轻2型糖尿病诱导的铁死亡所致内皮功能障碍DOI: 10.1039/d5fo04381f Acta radiologica IF: 01.100Ahead of Print.No.86Association of coronary computed tomography angiography-derived plaque characteristics and brain white matter hyperintensity: an observational study冠状动脉计算机断层血管造影衍生斑块特征与脑白质高信号的关联：一项观察性研究DOI: 10.1177/02841851261421597 其他发布内容（250） More Published Articles Cardiology in Review IF: 02.300Ahead of Print.No.01Metabolic Dysfunction-Associated Steatotic Liver Disease and Atherosclerotic Cardiovascular Disease: Shared Pathophysiology, Biomarkers, and Emerging Therapeutic Strategies代谢功能障碍相关脂肪性肝病与动脉粥样硬化性心血管疾病：共同的病理生理、生物标志物及新兴治疗策略DOI: 10.1097/CRD.0000000000001259 International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.02Frailty Modifies the Predictive Capacity of the Triglyceride-Glucose Index for Coronary Heart Disease衰弱改变甘油三酯-葡萄糖（TyG）指数对冠心病的预测能力DOI: 10.1536/ihj.25-460 International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.03Unmasking Risk Behind the Obesity-Paradox Signal: Prognostic Value of CONUT Score Combined with BMI揭示肥胖悖论信号背后的风险：联合BMI的CONUT评分的预后价值DOI: 10.1536/ihj.25-603 Dysphagia IF: 03.000Ahead of Print.No.04Exploring Factors Related to Dysphagia Among Community-Dwelling Older Adults: A Scoping Review探索社区居住老年人吞咽困难相关因素：一项范围综述DOI: 10.1007/s00455-026-10950-7 Osteoporosis international IF: 05.400Ahead of Print.No.05The burden of bone disease in Duchenne muscular dystrophy: age-specific prevalence of osteoporosis and low bone density杜氏肌营养不良症中的骨病负担：骨质疏松症和骨密度低下的年龄特异性患病率DOI: 10.1007/s00198-026-07963-1 Nature methods IF: 32.100Ahead of Print.No.06Compressing the collective knowledge of ESM into a single protein language model将ESM的集体知识压缩为单一蛋白质语言模型DOI: 10.1038/s41592-026-03050-9 Nature communications IF: 15.700Ahead of Print.No.07Lipidomic analyses of large cohort studies define the role of lipid metabolism in bridging diet and cardio-metabolic health大型队列研究的脂质组学分析定义了脂质代谢在连接饮食与心脏代谢健康中的作用DOI: 10.1038/s41467-026-71133-4 Scientific reports IF: 03.900Ahead of Print.No.08Multi-scale adaptive fusion network for retinal layer and fluid segmentation in optical coherence tomography B-scans光学相干断层扫描B扫描中视网膜层和液体分割的多尺度自适应融合网络DOI: 10.1038/s41598-026-44006-5 British Medical Journal IF: 42.700Volume 392, Issue No.09The wellness inspired rise of continuous glucose monitors for people without diabetes, including those with metabolic disorders健康意识驱动下无糖尿病患者（包括代谢紊乱患者）持续血糖监测仪的兴起DOI: 10.1136/bmj.s441 Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.10Dermoscopic Features of Onychomycosis Identified by Image Analysis Using a Decision Tree Algorithm使用决策树算法的图像分析识别甲癣的皮肤镜特征DOI: 10.5826/dpc.1601a6084 Infect Genet Evol IF: 02.600Ahead of Print.No.11Prevalence of Parabacteroides distasonis in Aleppo governorate and its antibiotic susceptibility profile狄氏副拟杆菌在阿勒颇省的流行情况及其抗生素敏感性概况DOI: 10.1016/j.meegid.2026.105934 Int J Biol Macromol IF: 08.500Ahead of Print.No.12Purification and characterisation of human heart recombinant PFK-2/FBPase-2 and evaluation of its possible inhibitors for the FBPase-2 domain人心脏重组PFK-2/FBPase-2的纯化与鉴定及其FBPase-2结构域可能抑制剂的评估DOI: 10.1016/j.ijbiomac.2026.151708 J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.13EPR26-147: Uncomplicated Diabetes and Adverse In-Hospital Outcomes in Tumor Lysis Syndrome: A National Cohort AnalysisEPR26-147：单纯性糖尿病与肿瘤溶解综合征中的不良住院结局：一项全国队列分析DOI: 10.6004/jnccn.2025.7162 Die Ophthalmologie IF: 00.600Ahead of Print.No.14[Diseases of the vitreoretinal interface : What role does the vitreous body play?]玻璃体视网膜界面疾病：玻璃体扮演什么角色DOI: 10.1007/s00347-026-02427-7 Am J Ophthalmol IF: 04.200Ahead of Print.No.15Macular OCTA Biomarkers Predict Regional Retinal Nonperfusion Patterns on Ultra-Widefield Angiography in Diabetes黄斑OCTA生物标志物可预测糖尿病超宽视野血管造影中的区域性视网膜无灌注模式DOI: 10.1016/j.ajo.2026.03.031 Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.16Topical Metformin Compared with Clobetasol Propionate for Alopecia Areata: Clinical Outcomes from a Comparative Study局部二甲双胍与丙酸氯倍他索治疗斑秃的比较研究：临床结果DOI: 10.5826/dpc.1601a5941 International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.17Validation and Comparison of ASCVD Risk Score and SCORE2-Diabetes in Japanese Patients with Diabetes Mellitus日本糖尿病患者中ASCVD风险评分与SCORE2-Diabetes的验证及比较DOI: 10.1536/ihj.25-627 International Heart Journal IF: 01.300Volume 67, Issue 2, Page 107-192No.18Association between Periaortic Adipose Tissue on Computed Tomography and Aortic Vulnerable Plaques Evaluated by Non-Obstructive General Angioscopy计算机断层扫描下主动脉周脂肪组织与非阻塞性全身血管镜评估的主动脉易损斑块之间的关联DOI: 10.1536/ihj.25-672 J Natl Compr Canc Netw IF: 16.400Ahead of Print.No.19Clinically Sufficient Vitamin D Levels With Survival and Cardiovascular Outcomes in a Prospective Cohort of 3,995 Individuals Diagnosed With Invasive Breast Cancer临床充足的维生素D水平与3995例浸润性乳腺癌患者的生存及心血管结局的前瞻性队列研究DOI: 10.6004/jnccn.2025.7111 BMJ Open Diabetes Res Care IF: 04.100Volume 14, Issue 2No.20Safety and efficacy of switching from dulaglutide to tirzepatide across clinically relevant baseline characteristics in participants with T2D: subgroup analysis of SURPASS-SWITCH在具有临床相关基线特征的2型糖尿病患者中从度拉糖肽转换为替尔泊肽的安全性和有效性：SURPASS-SWITCH的亚组分析DOI: 10.1136/bmjdrc-2025-005711 Acta Anaesthesiol Scand IF: 02.000Volume 70, Issue 5No.21Effects of Continuous Versus Intermittent Glucose Monitoring in Intensive Care Unit Patients: A Systematic Review With Meta-Analysis重症监护病房患者持续血糖监测与间歇性血糖监测的影响：系统综述与荟萃分析DOI: 10.1111/aas.70226 J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.22TIP26-314: Targeting Macrophage Migration Inhibitory Factor: A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 GliomasTIP26-314：靶向巨噬细胞迁移抑制因子——西格列汀在进行性4级胶质瘤患者中的2期和药效学研究DOI: 10.6004/jnccn.2025.7219 J Hum Nutr Diet IF: 02.500Volume 39, Issue 2No.23Effects of Undernutrition and Obesity on Functional and Nutritional Outcomes After Ischaemic Stroke: A Hospital-Based Study营养不良和肥胖对缺血性卒中后功能和营养结局的影响：一项基于医院的研究DOI: 10.1111/jhn.70240 Obesity surgery IF: 03.100Ahead of Print.No.24Real-world Physical Activity and Sedentary Time Trends in Patients Undergoing Obesity Treatment: Insights From the All of Us Research Program真实世界中接受肥胖治疗的患者体力活动与久坐时间趋势：来自All of Us研究项目的见解DOI: 10.1007/s11695-026-08645-x Obesity surgery IF: 03.100Ahead of Print.No.25Resting Energy Expenditure and Metabolic Adaptation Following Sleeve Gastrectomy in Hispanic Adults with Obesity肥胖西班牙裔成年人袖状胃切除术后的静息能量消耗及代谢适应DOI: 10.1007/s11695-026-08640-2 Nature methods IF: 32.100Ahead of Print.No.26Differentiation of sphingomyelin and cholesterol by hyperspectral mid-infrared detection of single-bond vibrational modes in the fingerprint region通过指纹区单键振动模式的高光谱中红外检测鉴别鞘磷脂和胆固醇DOI: 10.1038/s41592-026-03025-w European journal of pediatrics IF: 02.600Volume 185, Issue 4No.27Machine learning to predict hospital admission at triage in paediatric emergency care: A meta-analysis机器学习在儿科急诊分诊中预测住院的荟萃分析DOI: 10.1007/s00431-026-06895-6 European journal of pediatrics IF: 02.600Volume 185, Issue 4No.28Prediabetes in children and adolescents in Israel: a large-scale retrospective cohort study以色列儿童和青少年糖尿病前期：一项大规模回顾性队列研究DOI: 10.1007/s00431-026-06893-8 Hypertension Research IF: 04.600Ahead of Print.No.29Obesity and hypertensive renal arteriosclerosis in CKD慢性肾脏病中肥胖与高血压性肾动脉硬化DOI: 10.1038/s41440-026-02613-9 Diabetes care IF: 16.600Ahead of Print.No.30Genetic Susceptibility to Diabetes Subtypes and Risk of Developing Coronary Artery Disease糖尿病亚型的遗传易感性与冠心病发病风险DOI: 10.2337/dc25-1711 Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.31Association Between E-FABP Levels, Disease Severity, and Metabolic Parameters in Hidradenitis SuppurativaE-FABP水平与化脓性汗腺炎的疾病严重程度及代谢参数之间的关联DOI: 10.5826/dpc.1601a6217 Dermatol Pract Concept IF: 02.300Volume 16, Issue 1No.32Effectiveness of Biological Therapy in Psoriasis: Real-World Evaluation of SII and SIRI as Biomarkers of Systemic Inflammation生物疗法在银屑病中的有效性：作为全身炎症生物标志物的SII和SIRI真实世界评估DOI: 10.5826/dpc.1601a5943 The French journal of urologyAhead of Print.No.33Kidney transplantation in adult candidates with obesity: guidelines by the Association Française d'Urologie and Société Francophone de Transplantation成年肥胖候选者的肾脏移植：法国泌尿外科协会和法语区移植学会指南DOI: 10.1016/j.fjurol.2026.103100 J Natl Compr Canc Netw IF: 16.400Ahead of Print.No.34Results of the AiM, PLan, and act on LIFestYles (AMPLIFY) Weight Loss Intervention Among Survivors of Obesity-Related Cancers: A Randomized Clinical Trial肥胖相关癌症幸存者减重干预（AMPLIFY研究）的结果：一项随机临床试验DOI: 10.6004/jnccn.2026.7012 J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.35EPR26-183: Global and National Estimates of Genitourinary Cancer Mortality: The Impact of Obesity and Socioeconomic StatusEPR26-183：全球和国家泌尿生殖系统癌症死亡率估计：肥胖和社会经济地位的影响DOI: 10.6004/jnccn.2025.7264 J Natl Compr Canc Netw IF: 16.400Volume 24, Issue 3.5No.36EPR26-156: The Link Between Obesity and Cancer in a Latin American Population 2018-2024: Correspondence Analysis of Oncological OutcomesEPR26-156：2018-2024年拉丁美洲人群中肥胖与癌症的关联：肿瘤学结果对应分析DOI: 10.6004/jnccn.2025.7416 PharmacoEconomics - open IF: 02.100Ahead of Print.No.37Prevalence and Healthcare Costs of Metabolic Disorders Among Individuals with Schizophrenia Following Initiation of Oral Antipsychotic Therapy口服抗精神病药物治疗后精神分裂症患者代谢紊乱的患病率及医疗费用DOI: 10.1007/s41669-026-00647-w Nature medicine IF: 50.000Ahead of Print.No.38Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990-2023: a Global Burden of Disease study1990-2023年因饮食不合理导致的缺血性心脏病的全球、区域和国家负担：一项全球疾病负担研究DOI: 10.1038/s41591-026-04250-8 Aging cell IF: 07.100Volume 25, Issue 4No.39Targeting Mitochondrial Stress Responses: Terbinafine and Miglustat as Novel Lifespan and Healthspan Modulators靶向线粒体应激反应：特比萘芬和米格司他作为新型寿命与健康跨度调节剂DOI: 10.1111/acel.70452 J Gerontol A Biol Sci Med Sci IF: 03.800Ahead of Print.No.40Time-restricted feeding improves metabolic flexibility, promotes beiging, and mitigates fibro-inflammation in the adipose tissue of aged mice时间限制喂养改善衰老小鼠脂肪组织的代谢灵活性、促进米色化并减轻纤维化炎症DOI: 10.1093/gerona/glag085 Communications medicine IF: 06.300Ahead of Print.No.41Sex-specific cardiometabolic responses during microgravity simulation in European Space Agency VIVALDI dry immersion欧洲航天局VIVALDI干浸泡模拟微重力过程中性别特异性心脏代谢反应DOI: 10.1038/s43856-026-01540-7 Scientific reports IF: 03.900Volume 16, Issue 1No.42Changes in body mass index and waist circumference as predictors of incident prediabetes: the Aichi Workers' Cohort Study体重指数和腰围变化作为新发糖尿病前期的预测因素：爱知工人队列研究DOI: 10.1038/s41598-026-45909-z Niger J Clin Pract IF: 00.700Volume 29, Issue 3No.43Circulating Adropin and Preptin Levels in Non-alcoholic Steatohepatitis and Their Relationship with Carotid Intima Media Thickness: A Cross-Sectional Study from Türkiye来自土耳其的非酒精性脂肪性肝炎患者循环阿多宾和普瑞ptin水平及其与颈动脉内膜中层厚度的关系：一项横断面研究DOI: 10.4103/njcp.njcp_509_25 Trends Endocrinol Metab IF: 12.600Ahead of Print.No.44Palmitic and oleic acids in type 2 diabetes mellitus2型糖尿病中的棕榈酸和油酸DOI: 10.1016/j.tem.2026.01.003 Curr Opin Gastroenterol IF: 02.500Volume 42, Issue 3No.45Precision medicine in steatotic liver disease脂肪性肝病的精准医学DOI: 10.1097/MOG.0000000000001165 Vitamins and hormonesVolume 131, Issue No.46Growth hormone and glycemic metabolism生长激素与血糖代谢DOI: 10.1016/bs.vh.2025.10.003 Vitamins and hormonesVolume 131, Issue No.47Acromegaly and histopathology肢端肥大症与组织病理学DOI: 10.1016/bs.vh.2025.10.007 Vitamins and hormonesVolume 131, Issue No.48GH and GnRH-gonadotropin secretion生长激素与促性腺激素释放激素-促性腺激素分泌DOI: 10.1016/bs.vh.2025.10.002 Vitamins and hormonesVolume 131, Issue No.49Gigantism巨人症DOI: 10.1016/bs.vh.2025.10.005 Vitamins and hormonesVolume 131, Issue No.50Acromegaly and clinical manifestations肢端肥大症及其临床表现DOI: 10.1016/bs.vh.2025.10.004 Vitamins and hormonesVolume 131, Issue No.51Acromegaly: Biochemical diagnosis肢端肥大症：生化诊断DOI: 10.1016/bs.vh.2026.01.002 Vitamins and hormonesVolume 131, Issue No.52Growth hormone: Synthesis and regulation生长激素：合成与调节DOI: 10.1016/bs.vh.2025.10.001 Annales d'endocrinologie IF: 02.900Ahead of Print.No.53Facts and news about growth hormone replacement therapy in adults成人生长激素替代治疗的事实与新闻DOI: 10.1016/j.ando.2026.102547 Vitamins and hormonesVolume 131, Issue No.54Acromegaly-Physiopathology and etiology肢端肥大症-病理生理学和病因学DOI: 10.1016/bs.vh.2026.01.001 Vitamins and hormonesVolume 131, Issue No.55Acromegaly and genetics肢端肥大症与遗传学DOI: 10.1016/bs.vh.2025.10.008 CMAJ IF: 11.300Volume 198, Issue 12No.56Management of brain-heart multimorbidity: a clinical practice guideline脑心共病的管理：临床实践指南DOI: 10.1503/cmaj.251137 RheumatologyAhead of Print.No.57Cardioprotective mechanisms and effects of glucagon-like peptide-1 receptor agonists in autoimmune rheumatic diseases胰高血糖素样肽-1受体激动剂在自身免疫性风湿病中的心脏保护机制及作用DOI: 10.1093/rheumatology/keag147 Am J Physiol Cell Physiol IF: 04.700Volume 330, Issue 4No.58Vagal GABAergic signaling in autonomic control of cardiometabolic function迷走神经GABA能信号在心脏代谢功能自主控制中的作用DOI: 10.1152/ajpcell.00790.2025 JMIR diabetes IF: 02.600Volume 11, Issue No.59Exploring the Needs of Health Professionals for a Type 2 Diabetes Remote Patient Monitoring Dashboard for Personalized Care: Focus Group Study探索医疗专业人员对个性化护理用2型糖尿病远程患者监测仪表板的需求：焦点小组研究DOI: 10.2196/84894 Advances in physiology education IF: 01.700Ahead of Print.No.60Exploring physiology's past to inspire learning: an engaging undergraduate experience at the University of La Réunion探索生理学的历史以激发学习：留尼汪大学的沉浸式本科学习体验DOI: 10.1152/advan.00255.2025 Kidney & Blood Pressure Research IF: 02.100Ahead of Print.No.61Overweight and Obesity are Associated with Lower Renal Blood Flow in Autosomal Dominant Polycystic Kidney Disease超重和肥胖与常染色体显性多囊肾病患者的肾血流量降低相关DOI: 10.1159/000550949 Annals of Internal Medicine IF: 15.200Ahead of Print.No.62Summary for Patients: Fluvoxamine and Metformin for Fatigue in Patients With Long COVID新冠长期患者疲劳症状治疗的氟伏沙明与二甲双胍患者摘要DOI: 10.7326/ANNALS-25-03959-PS Annals of Internal Medicine IF: 15.200Ahead of Print.No.63The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial氟伏沙明和二甲双胍对长新冠患者疲劳的作用：一项适应性随机试验DOI: 10.7326/ANNALS-25-03959 Annals of Internal Medicine IF: 15.200Ahead of Print.No.64Patient-Reported Outcomes in People With Type 2 Diabetes Escalating Dulaglutide or Switching From Dulaglutide to Tirzepatide2型糖尿病患者度拉糖肽升级或切换至替尔泊肽时的患者报告结局DOI: 10.7326/ANNALS-25-03219 Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 14No.65Fatty acid regulation of feeding in Caenorhabditis elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system秀丽隐杆线虫中脂肪酸对摄食的调节揭示了类似GLP-1的多激动剂信号系统的潜在祖先起源DOI: 10.1073/pnas.2530979123 Proc Natl Acad Sci U S A IF: 09.100Volume 123, Issue 14No.66Regulation of STK38 by autophagy governs YAP1 activity during paligenosis自噬对STK38的调控在再生过程中控制YAP1活性DOI: 10.1073/pnas.2517488123 Diabetes IF: 07.500Ahead of Print.No.67LEAP2 Reduces Ad Libitum Food Intake and Attenuates Postprandial Glucose Excursions in Men With ObesityLEAP2减少肥胖男性的自由摄食并减轻餐后血糖波动DOI: 10.2337/db25-1132 Circulation IF: 38.600Volume 153, Issue 13No.68Response by Hundemer and Vaidya to Letter Regarding Article, "Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study"Hundemer和Vaidya对文章《亚临床原发性醛固酮增多症与主要不良心血管事件：一项基于人群的纵向队列研究》的回复DOI: 10.1161/CIRCULATIONAHA.125.079057 Diabetes care IF: 16.600Ahead of Print.No.69Impact of Missing Data and Monitoring Duration on Downstream Analyses in Continuous Glucose Monitoring连续血糖监测中缺失数据和监测时长对下游分析的影响DOI: 10.2337/dc25-2935 PloS one IF: 02.600Volume 21, Issue 3No.70Testing the feasibility of blood flow restriction training to enhance the HEALTH benefits of exercise in individuals with type 2 diabetes (BOOST-HEALTH Trial): Study Protocol测试血流限制训练在增强2型糖尿病患者运动健康益处方面的可行性（BOOST-HEALTH试验）：研究方案DOI: 10.1371/journal.pone.0346176 PloS one IF: 02.600Volume 21, Issue 3No.71Psychosocial predictors of non-adherence to antihypertensive medication among Korean adults: A nationwide cross-sectional study韩国成年人降压药物不依从的心理社会预测因素：一项全国性横断面研究DOI: 10.1371/journal.pone.0345509 Diabetes care IF: 16.600Ahead of Print.No.72Screening for Diabetes and Prediabetes in Cystic Fibrosis Using a Nonfasting 50-Gram 1-Hour Oral Glucose Challenge Test囊性纤维化中使用非空腹50克1小时口服葡萄糖耐量试验筛查糖尿病和前驱糖尿病DOI: 10.2337/dc25-2806 PloS one IF: 02.600Volume 21, Issue 3No.73Temporal-spatial trends in childbirth in Ontario, Canada加拿大安大略省分娩的时空趋势DOI: 10.1371/journal.pone.0342215 PloS one IF: 02.600Volume 21, Issue 3No.74Editorial Note: Machine learning-driven Diabetes Health Tracer (DHT): Optimizing prognosis using RaSK_GraDe and RaSK_GraDeL models社论注记：机器学习驱动的糖尿病健康追踪器（DHT）：使用RaSK_GraDe和RaSK_GraDeL模型优化预后DOI: 10.1371/journal.pone.0346001 PloS one IF: 02.600Volume 21, Issue 3No.75The effect of game-based education on adherence to treatment and anxiety level in type 2 diabetics started on insulin therapy游戏化教育对开始胰岛素治疗的2型糖尿病患者的治疗依从性和焦虑水平的影响DOI: 10.1371/journal.pone.0345292 Hormone research in p?diatrics : IF: 02.700Ahead of Print.No.76T1D GRS: a tool for identifying children and adolescents with monogenic diabetesT1D GRS：一种用于识别儿童和青少年单基因糖尿病的工具DOI: 10.1159/000551615 Age and ageing IF: 07.100Volume 55, Issue 3No.77Effectiveness of non-pharmacological and pharmacological interventions in preventing delirium in older adults: a systematic review and meta-analysis of randomised controlled trials非药物和药物干预措施在预防老年人谵妄中的有效性：一项随机对照试验的系统综述和荟萃分析DOI: 10.1093/ageing/afag068 Frontiers in physiology IF: 03.400Volume 17, Issue No.78MsrB2 deficiency amplifies ECM-driven cardiac fibrosis under hypertensive stress甲硫氨酸亚砜还原酶B2（MsrB2）缺陷在高血压应激下放大细胞外基质驱动的心脏纤维化DOI: 10.3389/fphys.2026.1772933 Gut microbes reportsVolume 3, Issue 1No.79Obesity-associated gut microbiome influences diet-induced metabolic and cognitive outcomes in older adults肥胖与肠道菌群作为老年人群认知衰退的关键驱动因素：系统综述与荟萃分析DOI: 10.1080/29933935.2025.2605879 iScience IF: 04.100Volume 29, Issue 4No.80Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration累积的mtDNA突变与NADH相关呼吸的特定损伤相关联DOI: 10.1016/j.isci.2026.115184 iScience IF: 04.100Volume 29, Issue 4No.81A Novel mechanism for depot-specific leptin gene expression regulation and its persistence after weight loss脂肪库特异性瘦素基因表达调控的新机制及其减重后的持续性DOI: 10.1016/j.isci.2026.115101 Frontiers in medicine IF: 03.000Volume 13, Issue No.82Limited transferability of European-based body mass index and blood pressure polygenic scores to admixed Brazilian cohorts英国生物样本库衍生多基因风险评分在巴西队列中的有限可转移性DOI: 10.3389/fmed.2026.1771205 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.83Six-year Follow-Up of Nonpharmacological and Nonsurgical Obesity Treatments非药物和非手术肥胖治疗的六年随访DOI: 10.2147/DMSO.S590255 JCEM case reportsVolume 4, Issue 4No.84Unanticipated remission of primary hyperparathyroidism following cinacalcet西那卡塞治疗后原发性甲状旁腺功能亢进症的意外缓解DOI: 10.1210/jcemcr/luag014 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.85Continuous glucose monitoring, diabetes distress, and well-being in adults with type 1 diabetes: findings from a National Survey in Lithuania连续性葡萄糖监测、1型糖尿病患者的糖尿病困扰及幸福感：来自立陶宛全国性调查的结果DOI: 10.3389/fcdhc.2026.1708124 Preventive medicine reports IF: 02.400Volume 65, Issue No.86Sex differences in the prospective associations of long COVID with incident cardiometabolic and respiratory diseases from a population-based longitudinal study in Michigan密歇根州基于人群的纵向研究中，长期新冠与新发心血管代谢及呼吸系统疾病关联的性别差异DOI: 10.1016/j.pmedr.2026.103449 J Clin Exp Hepatol IF: 03.200Volume 16, Issue 3No.87The Association Between Genetic Polymorphism in the Receptor for Advanced Glycation End-Products and Metabolic Dysfunction-Associated Steatotic Liver Disease晚期糖基化终产物受体基因多态性与代谢功能障碍相关脂肪性肝病的关联DOI: 10.1016/j.jceh.2026.103530 Kidney medicine IF: 03.400Volume 8, Issue 4No.88Primary Care Use and Clinical Outcomes in a Prevalent Cohort of Patients Receiving Hemodialysis接受中心性血液透析的医疗保险受益人中初级医疗服务使用情况及临床结局DOI: 10.1016/j.xkme.2026.101278 In silico pharmacologyVolume 14, Issue 1No.89NMR-guided metabolomic evaluation of Aegle marmelos (L.) Correa: unveiling antihypertensive, antidiabetic, and anti-inflammatory activitiesNMR引导的木苹果代谢组学评估：揭示其抗高血压、抗糖尿病及抗炎活性DOI: 10.1007/s40203-026-00609-4 Bioinformation IF: 01.900Volume 21, Issue 12No.90Maternal obesity and its impact on pregnancy孕妇肥胖及其对妊娠的影响DOI: 10.6026/973206300214648 Bioinformation IF: 01.900Volume 21, Issue 12No.91Oral lesions in patients with systemic diseases: A hospital-based observational study系统性疾病患者的口腔病变：一项基于医院的观察性研究DOI: 10.6026/973206300214359 J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.92Evaluation of the circular RNA Pum1_0014, miRNA-146a, and miRNA-141-3p as biomarkers in PCOSPum1_0014环状RNA、miRNA-146a和miRNA-141-3p作为多囊卵巢综合征生物标志物的评估DOI: 10.1016/j.jtumed.2026.03.002 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.93Metabolic-associated steatotic liver disease in children and adolescents: a scoping review and narrative synthesis of epidemiology, risk factors, and screening approaches with emerging implications for sub-Saharan Africa撒哈拉以南非洲地区儿童代谢相关脂肪性肝病：范围综述DOI: 10.3389/fendo.2026.1784970 Int J Nanomedicine IF: 06.500Volume 21, Issue No.94Chitosan-Microcapsulated Insulin Alleviates Mesenteric Microcirculation Dysfunction via Modulating COX-2 and VCAM-1 Expression in Rats with Diabetes Mellitus [Retraction]壳聚糖微囊化胰岛素通过调节糖尿病大鼠COX-2和VCAM-1表达改善肠系膜微循环功能障碍 [撤稿]DOI: 10.2147/IJN.S599834 Acta Cardiologica Sinica IF: 01.800Volume 42, Issue 2No.95Nirmatrelvir/Ritonavir-Induced Calcium Channel Blocker Intoxication Successfully Treated by High Dose Insulin Therapy奈玛特韦/利托那韦诱导的钙通道阻滞剂中毒经大剂量胰岛素治疗成功DOI: 10.6515/ACS.202603_42(2).20251213B Br J Community NursVolume 31, Issue 4No.96Management of diabetes when comorbid with dementia痴呆合并糖尿病的管理DOI: 10.12968/bjcn.2026.0042 Curēus IF: 01.300Volume 18, Issue 2No.97Differentiated and Poorly Differentiated Thyroid Carcinoma in Ovarian Teratoma With Primary Papillary Thyroid Carcinoma: A Series of Two Case Reports卵巢畸胎瘤中合并原发性乳头状甲状腺癌的分化型和未分化型甲状腺癌：两例病例报告DOI: 10.7759/cureus.104169 Curēus IF: 01.300Volume 18, Issue 2No.98Exercise Intervention for Blood Pressure Reduction in Diabetic Patients: A Systematic Review and Meta-Analysis糖尿病患者的血压降低运动干预：一项系统综述和荟萃分析DOI: 10.7759/cureus.104244 Curēus IF: 01.300Volume 18, Issue 2No.99Clinico-Microbiological Profile of Carbapenem-Resistant Acinetobacter baumannii Isolates From Intensive Care Unit Patients and In Vitro Activity of Sulbactam-Durlobactam: A Cross-Sectional Study From Eastern India印度东部三级医院重症监护病房中碳青霉烯耐药鲍曼不动杆菌的临床及抗菌药物敏感性分析DOI: 10.7759/cureus.104172 Curēus IF: 01.300Volume 18, Issue 2No.100Intramedullary Spinal Cord Abscess With Brain Abscess Secondary to Empyema: A Report of a Rare Case继发于脓胸的髓内脊髓脓肿合并脑脓肿：一例罕见病例报告DOI: 10.7759/cureus.104151 Curēus IF: 01.300Volume 18, Issue 2No.101Assessing Mortality Prediction: Comparing the Effectiveness of the Fournier Gangrene Severity Index and the Uludag Index评估死亡率预测：比较Fournier坏疽严重度指数与Uludag指数的有效性DOI: 10.7759/cureus.104290 Curēus IF: 01.300Volume 18, Issue 2No.102Emphysematous Gastritis With Portal and Mesenteric Venous Gas Complicated by Septic Shock and Ileus: A Case Report伴有门静脉和肠系膜静脉气体的气肿性胃炎，表现为严重休克和肠梗阻：一例报告及文献综述DOI: 10.7759/cureus.104164 Frontiers in nutrition IF: 05.100Volume 13, Issue No.103Barriers and facilitators for consuming a plant-based diet in patients with knee osteoarthritis: a qualitative study膝关节骨关节炎患者食用植物性饮食的障碍与促进因素：一项定性研究DOI: 10.3389/fnut.2026.1743219 J Public Health ResVolume 15, Issue 1No.104In-hospital mortality and its predictors among adult ischemic stroke patients in public hospitals in the Harari region, Eastern Ethiopia: A retrospective cohort study埃塞俄比亚东部哈拉里市公立医院成人缺血性卒中患者的死亡率及其预测因素：一项回顾性队列研究DOI: 10.1177/22799036261433150 Kidney medicine IF: 03.400Volume 8, Issue 4No.105Outcomes and Risk Factors of Widened Difference in Estimated Glomerular Filtration Rate Based on Creatinine or Cystatin C: Adjust Model Development With More Than 300,000 UK Biobank Participants慢性肾脏病流行病学协作组（CKD-EPI）基于肌酐、胱抑素C及两者结合估算肾小球滤过率（eGFR）：英国生物样本库中的差异分析与预测价值DOI: 10.1016/j.xkme.2026.101288 Infection and drug resistance IF: 02.900Volume 19, Issue No.106Management of Diabetic Foot Infections Using Phage Therapy噬菌体疗法在糖尿病足感染中的综合综述DOI: 10.2147/IDR.S577526 Curēus IF: 01.300Volume 18, Issue 2No.107Unprovoked Deep Vein Thrombosis as a Manifestation of Cushing's Disease自发性深静脉血栓形成作为库欣病的一种表现DOI: 10.7759/cureus.104148 Farmaceuticos comunitarios IF: 00.500Volume 18, Issue 2No.108Mystery Shopper: Antibiotics for sale at flea markets in a Mexican urban area神秘购物者：墨西哥城市地区跳蚤市场中抗生素的销售情况DOI: 10.33620/FC.2173-9218.2026.16 Bioinformation IF: 01.900Volume 21, Issue 12No.109Gender differences in outcomes among patients with heart failure and preserved ejection fraction: A retrospective cohort study射血分数保留的心力衰竭患者结局中的性别差异：一项回顾性队列研究DOI: 10.6026/973206300214355 Safety and health at work IF: 02.900Volume 17, Issue 1No.110Do the Long-Term Cardiometabolic Effects of Night Shift Work Differ Between Men and Women? A 17-Year Cohort Study of the U.S. Workforce夜班工作对男女心代谢健康的长期影响是否存在差异？一项针对美国劳动力的17年队列研究DOI: 10.1016/j.shaw.2025.11.001 FCVM IF: 02.900Volume 13, Issue No.111Impact of a combined care ambulatory and home-based aerobic exercise program using wearables on anxiety and depression in patients with metabolic syndrome结合门诊和家庭有氧运动项目及远程可穿戴设备监测改善代谢综合征患者的焦虑和抑郁症状DOI: 10.3389/fcvm.2026.1798233 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.112Selective phosphoinositide 3-kinase inhibitors and implication in diabetic retinopathy as pharmacological tools磷酸肌醇3-激酶异构体选择性及定量构效关系（QSAR）在糖尿病视网膜病变药物设计中的研究DOI: 10.3389/fphar.2026.1744181 Int Med Case Rep J IF: 00.600Volume 19, Issue No.113Bilateral Superior Branch Retinal Artery Occlusions in a Patient on Pembrolizumab使用帕博利珠单抗治疗的患者出现双眼分支视网膜动脉闭塞DOI: 10.2147/IMCRJ.S584574 Frontiers in medicine IF: 03.000Volume 13, Issue No.114Diabetic retinopathy severity detection using an improved Whale optimization algorithm and convolutional Kolmogorov-Arnold network使用改进鲸鱼优化算法和卷积Kolmogorov-Arnold网络的糖尿病视网膜病变严重程度检测DOI: 10.3389/fmed.2026.1709872 Preventive medicine reports IF: 02.400Volume 65, Issue No.115Nationwide trends and geographic variations of diabetes in pregnancy in Thailand: Epidemiology, neonatal outcomes, and healthcare costs under the universal health coverage scheme (2013-2023)泰国妊娠期糖尿病全国趋势与地理变异：全民医保计划下的流行病学、新生儿结局及医疗费用（2013-2023）DOI: 10.1016/j.pmedr.2026.103452 J Diabetes Metab Disord IF: 01.600Volume 25, Issue 1No.116The transformative role of artificial intelligence in gestational diabetes mellitus: advancements in screening, management, and long-term outcome prediction人工智能在妊娠糖尿病管理中的变革性作用：筛查、管理及长期预后预测的进展DOI: 10.1007/s40200-025-01817-z Bioinformation IF: 01.900Volume 21, Issue 12No.117Prevalence of gestational diabetes using IADPSG criteria in North India: A cross-sectional study北印度地区应用IADPSG标准的妊娠糖尿病患病率：一项横断面研究DOI: 10.6026/973206300214876 Bioinformation IF: 01.900Volume 21, Issue 12No.118Impact of thyroid autoantibodies on pregnancy: A prospective cohort study甲状腺自身抗体对妊娠的影响：一项前瞻性队列研究DOI: 10.6026/973206300214749 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.119Machine Learning-Derived Predictive Risk Score for Prediabetes and Type 2 Diabetes Development in Parous WomenG4PD指数：机器学习推导的经产妇女糖尿病前期和2型糖尿病风险评分DOI: 10.2147/DMSO.S590000 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.120Prediabetes in acute coronary syndrome: an overlooked predictor of adverse outcomes糖尿病前期在急性冠脉综合征中的作用：被忽视的不良结局预测因子DOI: 10.3389/fcdhc.2026.1745724 Glob Cardiol Sci PractVolume 2025, Issue 2No.121Evaluation of electrocardiographic alterations before and after bariatric surgery重度肥胖患者减重手术前后的心电图变化DOI: 10.21542/gcsp.2025.22 J Cardiovasc Surg (Torino) IF: 01.500Ahead of Print.No.122Operative time and outcome after carotid endarterectomy for symptomatic and asymptomatic carotid stenosis: a retrospective multicenter cohort study有症状和无症状颈动脉狭窄患者颈动脉内膜切除术的手术时间与结局：一项回顾性多中心队列研究DOI: 10.23736/S0021-9509.26.13541-1 East Mediterr Health J IF: 01.900Volume 32, Issue 3No.123Association between vitamin D deficiency and metabolic syndrome among adults in Arab countries阿拉伯国家成年人维生素D缺乏与代谢综合征的关联DOI: 10.26719/2026.32.3.156 Gut microbes reportsVolume 2, Issue 1No.124Gut microbial metabolites as a convergence point between autoimmunity and solid tumors肠道微生物群在连接自身免疫性疾病与癌症中的作用DOI: 10.1080/29933935.2025.2470805 Curēus IF: 01.300Volume 18, Issue 2No.125Association of Gastrointestinal Symptoms and Psychological Issues With the Intake of Fruits, Vegetables, and Junk Food in School Children: A Community-Based Study From Melmaruvathur, Tamil Nadu, India印度泰米尔纳德邦学童中显著的胃肠道症状、心理问题及异常营养状况：一项基于社区的研究DOI: 10.7759/cureus.104262 Curēus IF: 01.300Volume 18, Issue 2No.126Racial and Gender Disparities in the Occurrence and Outcomes of Alcohol-Associated Hepatitis in Hospitalized Patients With Prior Bariatric Surgery减重手术后酒精性肝炎的结局：基于全国住院患者样本的分析DOI: 10.7759/cureus.104251 Curēus IF: 01.300Volume 18, Issue 2No.127Skin-Only Closure Versus Bogota Bag: A Comparative Study of Complete Fascial Approximation Rates皮肤仅闭合术与波哥大袋闭合术：完整筋膜近似率的对比研究DOI: 10.7759/cureus.104203 Curēus IF: 01.300Volume 18, Issue 2No.128Spectrum and Management of Anorectal Disorders: A Retrospective Analysis From the United Arab Emirates阿联酋肛门直肠疾病回顾性分析：人口统计学特征、临床表现与管理策略DOI: 10.7759/cureus.104155 JCEM case reportsVolume 4, Issue 4No.129Phenotypic heterogeneity and polygenic risk scores in a family of maturity-onset diabetes of the young青年成熟期糖尿病家族的表型异质性与多基因风险评分DOI: 10.1210/jcemcr/luag001 Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.130Obesity and Knee Arthroplasty: One Size Does Not Fit All-A Review with an Indian Perspective肥胖与膝关节置换术：一刀切并不适用——从印度视角的综述DOI: 10.1007/s43465-025-01669-y Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.131Functional Outcome of Single Bundle ACL Reconstruction with Superficial Quadriceps Tendon Graft in an Indian Cohort: A 3-Year Study印度队列中浅层股四头肌肌腱单束前交叉韧带重建的功能结果：一项为期3年的研究DOI: 10.1007/s43465-026-01750-0 Indian journal of orthopaedics IF: 01.100Volume 60, Issue 3No.132Impact of Glucagon-Like Peptide-1 Receptor Agonists on Knee Arthroplasty Outcomes胰高血糖素样肽-1受体激动剂与全膝关节置换术结局：一项系统综述和荟萃分析DOI: 10.1007/s43465-025-01646-5 Frontiers in public health IF: 03.400Volume 14, Issue No.133From gene to plate in Indonesia: a food system framework for the triple burden of malnutrition遗传创新、生物多样性与气候智能型农业：秘鲁、印度尼西亚和南非应对三重营养不良负担的系统性方法DOI: 10.3389/fpubh.2026.1755411 Curēus IF: 01.300Volume 18, Issue 3No.134Defining, Evaluating, and Managing Postoperative Respiratory Depression: An e-Delphi Study术后呼吸抑制（PORD）的共识定义与临床框架：一项电子德尔菲研究DOI: 10.7759/cureus.104612 J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.135Effectiveness of a school-based obesity control program among adolescents in Makkah: A pretest-posttest intervention study麦加青少年基于学校的肥胖控制项目的有效性：一项前测-后测干预研究DOI: 10.1016/j.jtumed.2026.03.005 J Taibah Univ Med Sci IF: 01.900Volume 21, Issue 2No.136Variations in serum ferritin levels in women with polycystic ovarian syndrome undergoing assisted reproduction接受辅助生殖治疗的多囊卵巢综合征女性血清铁蛋白水平的变化DOI: 10.1016/j.jtumed.2026.03.004 Bioinformation IF: 01.900Volume 21, Issue 12No.137Assessment of health management strategies and socioeconomic factors contributing to obesity in urban populations城市人群中健康管理策略及社会经济因素对肥胖的影响评估DOI: 10.6026/973206300215038 ArXivVolume 2026, Issue No.138Modeling Metabolic State Transitions in Obesity Using a Time-Varying Lambda-Omega Framework使用时变λ-Ω框架模拟肥胖中的代谢状态转变https://pubmed.ncbi.nlm.nih.gov/41907585 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.139The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives促黑素激动剂：从临床前失败到肥胖治疗的新兴疗法DOI: 10.3389/fendo.2026.1797586 Frontiers in physiology IF: 03.400Volume 17, Issue No.140Effects of psychophysiological stress on perceptual responses during low-volume high intensity interval exercise: insights from ACTH and cortisol in overweight-to-obese adults低容量高强度间歇运动改善超重和肥胖成人的心理生理应激及感知反应DOI: 10.3389/fphys.2026.1762153 Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 3No.141Management of Severe Buried Penis With Bilateral Hernia重度埋藏阴茎合并双侧疝的管理DOI: 10.1097/GOX.0000000000007601 FCVM IF: 02.900Volume 13, Issue No.142The impact of body composition variability on coagulation monitoring in patients on direct oral factor Xa inhibitors for treatment of venous thromboembolism生物信息指导的抗Xa治疗（BIARIVA）中的体成分与凝血监测：一项初步研究DOI: 10.3389/fcvm.2026.1773664 Acta Cardiologica Sinica IF: 01.800Volume 42, Issue 2No.143Goal Attainment Rate in Secondary Prevention in Taiwan - A Chang Gung Research Database Study台湾动脉粥样硬化性心血管疾病患者二级预防中低密度脂蛋白胆固醇目标达标率研究——基于长庚研究数据库DOI: 10.6515/ACS.202603_42(2).20251012A Expert Rev Clin Pharmacol IF: 03.000Ahead of Print.No.144Pharmacokinetics, efficacy, and safety of arsenic formulations in acute promyelocytic leukemia treatment急性早幼粒细胞白血病治疗中砷制剂的药代动力学、有效性和安全性DOI: 10.1080/17512433.2026.2652979 Kidney medicine IF: 03.400Volume 8, Issue 4No.145SGLT2 Inhibitors, Muscle Loss, and Creatinine-Based Estimated GFR: An Integrative Conceptual Review of Renoprotection基于肌酐的eGFR终点评估中肌肉质量流失对SGLT2抑制剂肾脏保护作用的影响DOI: 10.1016/j.xkme.2026.101297 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.146Safety and efficacy of tirzepatide in transplant recipients: a systematic review and meta-analysis替尔泊肽在实体器官移植受者中的安全性和有效性：一项系统综述和荟萃分析DOI: 10.3389/fphar.2026.1735987 Pediatrics international IF: 00.900Volume 68, Issue 1No.147A nonsurgical cecal slurry model for neonatal sepsis: Pathophysiological insights and therapeutic applications用于新生儿败血症的非手术盲肠浆模型：病理生理学见解与治疗应用DOI: 10.1111/ped.70381 Frontiers in reproductive health IF: 02.900Volume 8, Issue No.148Correction: The role and underlying mechanisms of Qi Gong Wan in enhancing the endometrial receptivity of a rat model with polycystic ovary syndrome修正：芪功丸在增强多囊卵巢综合征大鼠模型子宫内膜容受性中的作用及潜在机制DOI: 10.3389/frph.2026.1826232 Curēus IF: 01.300Volume 18, Issue 2No.149Exploring the Immunological Shield Hypothesis: A Population-Based Exploration of Phenotypic Divergence Between Lipedema and Celiac Disease Autoimmunity脂肪性水肿与乳糜泻：全国代表性大样本中的不同表型DOI: 10.7759/cureus.104222 Curēus IF: 01.300Volume 18, Issue 2No.150Necrobiosis Lipoidica in Pregnancy Complicated by Gestational Diabetes Mellitus: A Case Report妊娠期糖尿病合并坏死性类脂质硬化症病例报告DOI: 10.7759/cureus.104273 Curēus IF: 01.300Volume 18, Issue 2No.151Insulin Glulisine Versus Regular Human Insulin for Prednisolone-Associated Hyperglycemia Assessed by Continuous Glucose Monitoring: An Open-Label Crossover Study连续葡萄糖监测评估的赖脯胰岛素与常规人胰岛素治疗泼尼松龙相关高血糖的开放标签交叉研究DOI: 10.7759/cureus.104228 Am J Lifestyle Med IF: 01.300Ahead of Print.No.152Medication Deprescribing Practices Among Lifestyle Medicine Providers: A Cross-Sectional Survey生活方式医学临床医生在启动生活方式医学糖尿病管理后调整降糖药物的调查DOI: 10.1177/15598276261430281 Discover analyticsVolume 4, Issue 1No.153Flexible statistical approaches for modeling nonlinear relationships in diabetes prediction using splines, Bayesian kernel regression and Bayesian regression trees使用皮马印第安人数据库进行糖尿病预测的非线性统计方法比较分析DOI: 10.1007/s44257-026-00057-6 Genom PsychiatryVolume 1, Issue 4No.154Varying levels of interleukin 1 receptor antagonist (Il1rn) gene expression affect circulating leptin concentrations and fat distribution白细胞介素1受体拮抗剂（Il1rn）基因表达水平的变化影响循环瘦素浓度和脂肪分布DOI: 10.61373/gp025l.0056 Toxicon X IF: 02.800Volume 30, Issue No.155Biochemical characterisation and substrate-specific proteolytic diversity of venom metalloproteinases in African puff adders非洲黑眉蝮蛇（Bitis arietans）毒液金属蛋白酶的生化与免疫学特征DOI: 10.1016/j.toxcx.2026.100253 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.156Cumulative burden of diabetes-related complications and health-related quality of life in primary care: a cross-sectional study from Mexico墨西哥基层医疗中2型糖尿病相关并发症累积负担及健康相关生活质量研究：一项横断面研究DOI: 10.3389/fcdhc.2026.1773692 3 biotech IF: 02.900Volume 16, Issue 4No.157α-Glucosidase inhibitor: identifying key targets and mechanisms in type 2 diabetesα-葡萄糖苷酶抑制剂：识别2型糖尿病的关键靶点和机制DOI: 10.1007/s13205-026-04772-5 Frontiers in medicine IF: 03.000Volume 13, Issue No.158Skin lesions in patients treated with growth hormone and those with growth hormone excess: a current overview接受生长激素治疗患者及生长激素过多患者的皮肤表现：当前综述DOI: 10.3389/fmed.2026.1777658 Neurochemical research IF: 03.800Volume 51, Issue 2No.159Vitamin D(3) Attenuates Alzheimer's Disease-Like Pathology via Remodeling Amyloid Protein Production and Clearance Pathway in Wistar Rats维生素D₃通过重塑淀粉样蛋白产生与清除途径减轻Wistar大鼠的阿尔茨海默病样病理DOI: 10.1007/s11064-026-04721-x Tremor Other Hyperkinet Mov (N Y) IF: 02.100Volume 16, Issue No.160Paroxysmal Hemidystonia as the Presenting Manifestation of Previously Undiagnosed Diabetes Mellitus发作性偏身肌张力障碍作为既往未诊断糖尿病的首发表现DOI: 10.5334/tohm.1185 Curēus IF: 01.300Volume 18, Issue 2No.161Weight Regain After GLP-1-Based Therapy Discontinuation: Failure, Physiology, or Follow-Up GapGLP-1受体激动剂疗法停药后的体重反弹：失败、生理机制还是随访缺口DOI: 10.7759/cureus.104259 Int J Nephrol Renovasc Dis IF: 02.500Volume 19, Issue No.162Current Insights and Future Directions on the Role of GLP-1 Receptor Agonists in Chronic Kidney DiseaseGLP-1受体激动剂在慢性肾脏病中的应用现状与未来方向DOI: 10.2147/IJNRD.S522424 Plast Reconstr Surg Glob Open IF: 01.800Volume 14, Issue 3No.163The Glucagon-like Peptide-1 Receptor Agonist Era and Its Influence on Body-Contouring Referrals After Weight Loss in Appalachia胰高血糖素样肽-1受体激动剂时代及其对阿巴拉契亚地区减重后体型塑造转诊的影响DOI: 10.1097/GOX.0000000000007620 Int J Gen Med IF: 02.000Volume 19, Issue No.164Association Between Genotype and Plasma Levels of EPCR in Type 2 Diabetes Mellitus in Jazan Region, Saudi Arabia: A Case-Control Study内皮蛋白C受体（EPCR）多态性rs867186与2型糖尿病患者血浆可溶性EPCR水平及血液学参数的关联DOI: 10.2147/IJGM.S566052 Curēus IF: 01.300Volume 18, Issue 2No.165Fulminant Toxic Megacolon Without Identifiable Underlying Cause Requiring Emergent Total Colectomy: A Case Report暴发性中毒性巨结肠无明确根本病因需紧急全结肠切除一例报告DOI: 10.7759/cureus.104288 Curēus IF: 01.300Volume 18, Issue 2No.166A Rare Case of Tirzepatide-Associated Immune Thrombocytopenia替尔泊肽相关免疫性血小板减少症的罕见病例DOI: 10.7759/cureus.104281 Curēus IF: 01.300Volume 18, Issue 2No.167Drug Prescribing Patterns in Geriatric Patients With Type 2 Diabetes Mellitus at a Tertiary Care Teaching Hospital: A Cross-Sectional Study老年2型糖尿病患者在三级医院的处方模式：一项真实世界观察性研究DOI: 10.7759/cureus.104264 Curēus IF: 01.300Volume 18, Issue 2No.168X-ray Findings in a Case of Acute Osteomyelitis Following Puncture Injury: A Case Report穿刺伤后急性骨髓炎一例的X线表现：病例报告DOI: 10.7759/cureus.104291 Curēus IF: 01.300Volume 18, Issue 2No.169Where Is the Lactate Coming From? An Unusual Presentation of Persistent Lactic Acidosis乳酸从何而来？持续性乳酸酸中毒的罕见表现DOI: 10.7759/cureus.104328 Curēus IF: 01.300Volume 18, Issue 2No.170Understanding Diabetes Distress: A Study of Contributing Factors Among Adults With Type 2 Diabetes in Rural East Godavari, Andhra Pradesh印度安得拉邦农村地区2型糖尿病成年患者糖尿病困扰的患病率及相关因素DOI: 10.7759/cureus.104183 Curēus IF: 01.300Volume 18, Issue 2No.171Determinants of Left Ventricular Diastolic Dysfunction in Normotensive Patients With Type 2 Diabetes Mellitus: A Tertiary Hospital-Based Study in Ghana正常血压2型糖尿病患者左心室舒张功能障碍的决定因素：基于加纳一家三级医院的研究DOI: 10.7759/cureus.104317 J Public Health ResVolume 15, Issue 1No.172Traditional diets and cultural beliefs affecting diabetes prevention and control in Africa撒哈拉以南非洲2型糖尿病预防与控制：传统非洲饮食和以社区为中心的方法综合综述DOI: 10.1177/22799036261430965 Bioinformation IF: 01.900Volume 21, Issue 12No.173Management of type 2 diabetes mellitus using Yoga: Implications for immunological and autonomic dysfunction使用瑜伽管理2型糖尿病：对免疫和自主神经功能障碍的影响DOI: 10.6026/973206300214777 Bioinformation IF: 01.900Volume 21, Issue 12No.174Salivary and serum alkaline phosphatase as biomarkers in type 2 diabetes mellitus: Association with periodontal health and disease唾液和血清碱性磷酸酶作为2型糖尿病的生物标志物：与牙周健康和疾病的关联DOI: 10.6026/973206300214559 Bioinformation IF: 01.900Volume 21, Issue 12No.175Evaluation of antioxidant enzyme activity among Indian patients with type 2 diabetes mellitus印度2型糖尿病患者抗氧化酶活性的评估DOI: 10.6026/973206300215029 Bioinformation IF: 01.900Volume 21, Issue 12No.176Integrative management of chronic kidney disease: A case study combining siddha and modern medicine慢性肾脏病的综合管理：结合悉达（传统）医学与现代医学的案例研究DOI: 10.6026/973206300214344 Clinical ophthalmology IF: 02.200Volume 20, Issue No.177Glucagon-Like Peptide-1 Analogs Associated with a Reduced Risk of Legal Blindness in Type 2 Diabetics with Cardiovascular Risks胰高血糖素样肽-1受体激动剂降低2型糖尿病合并心血管风险因素患者的法律失明风险DOI: 10.2147/OPTH.S581826 Front Mol Biosci IF: 04.000Volume 13, Issue No.178Non-coding RNA biomarkers in resistant hypertension: a scoping review抵抗性高血压中的循环非编码RNA生物标志物：一项范围综述DOI: 10.3389/fmolb.2026.1786399 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.179Real-World Effectiveness and Safety of Imeglimin in Type 2 Diabetes: Prospective Multi-Center Study in Bangladesh伊格列净在2型糖尿病中的真实世界观察性研究——孟加拉国患者DOI: 10.2147/DMSO.S576436 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.180Significant shortening of leukocyte telomeres one year after childbirth in women with type 1 diabetes mellitus: a prospective cohort study1型糖尿病女性分娩后一年内白细胞端粒显著缩短：一项前瞻性队列研究DOI: 10.3389/fcdhc.2026.1776531 Journal of inflammation research IF: 04.100Volume 19, Issue No.181Diagnosis and Management of Comorbid Autoimmune Disorders in Children with Chronic Spontaneous Urticaria儿童慢性自发性荨麻疹患者合并自身免疫性疾病的诊断与管理DOI: 10.2147/JIR.S558731 Frontiers in veterinary science IF: 02.900Volume 13, Issue No.182Case Report: Bexagliflozin as an adjunct decongestive strategy in a cat with congestive heart failure and advanced chronic kidney disease病例报告：贝格列净作为伴充血性心力衰竭和晚期慢性肾脏病猫的辅助减充血策略DOI: 10.3389/fvets.2026.1791139 FCVM IF: 02.900Volume 12, Issue No.183Safety and efficacy of physical activity in hypertrophic cardiomyopathy patients: a systematic review and metanalysis肥厚型心肌病患者的运动：安全性和有效性的荟萃分析DOI: 10.3389/fcvm.2025.1739956 Kidney international reports IF: 05.700Volume 11, Issue 5No.184Cystatin C Confirms the Canagliflozin eGFR Slope Benefit in CANPIONE卡格列净对基于胱抑素C的估算肾小球滤过率斜率的影响DOI: 10.1016/j.ekir.2026.106374 Circulation IF: 38.600Ahead of Print.No.185Effect of APOC3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study奥雷沙恩抑制载脂蛋白C-III对冠状动脉粥样硬化的影响：Essence-TIMI 73b成像研究DOI: 10.1161/CIRCULATIONAHA.126.080012 Frontiers in nutrition IF: 05.100Volume 13, Issue No.186Potential lipid-lowering effects of Coffea arabica pulp extract product in hyperlipidemia-obese subjects: a randomized double-blind placebo-controlled trial绿原酸富集的咖啡果渣提取物改善高脂血症和肥胖成人的脂质谱：一项随机、双盲、安慰剂对照试验DOI: 10.3389/fnut.2026.1755054 Curēus IF: 01.300Volume 18, Issue 2No.187Holmes Tremor Secondary to a Brainstem Haemorrhage With Partial Symptomatic Improvement Following Levetiracetam Use左乙拉西坦使用后部分症状改善的脑干出血继发霍姆斯震颤DOI: 10.7759/cureus.104226 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.188Gabapentin CNS exposure and analgesic response are modulated by OCT2 genotype in patients with chronic neuropathic pain加巴喷丁中枢神经系统暴露和镇痛反应受慢性神经病理性疼痛患者中OCT2基因型调节DOI: 10.3389/fphar.2026.1760901 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.189GLP-1 Receptor Agonist Therapy in Older Adults with Diabetes: A Qualitative Analysis of Phase 4 ClinicalTrials.gov StudiesGLP-1受体激动剂在2型糖尿病老年患者中的应用：4期临床试验的定性分析DOI: 10.2147/DMSO.S584052 NEJM IF: 78.500Ahead of Print.No.190IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease血管内超声引导与血管造影引导在无保护左主干冠状动脉疾病中的经皮冠状动脉介入治疗比较DOI: 10.1056/NEJMoa2600440 Current obesity reports IF: 11.000Volume 15, Issue 1No.191Beyond the Scale: Setting Goals for Outcomes Beyond Weight in Evidence-based Obesity Treatment超越体重秤：在循证肥胖治疗中设定超越体重的结局目标DOI: 10.1007/s13679-026-00706-7 Rev Endocr Metab Disord IF: 08.000Ahead of Print.No.192Hypothalamus-liver talks: whispers in the language of metabolism下丘脑-肝脏对话：代谢语言中的低语DOI: 10.1007/s11154-026-10031-y J Comput Aided Mol Des IF: 03.100Volume 40, Issue 1No.193In silico and in vitro study for the limonoid isolated from Swietenia macrophylla as potential α-glucosidase inhibitor桃花心木中分离的柠檬苦素作为潜在α-葡萄糖苷酶抑制剂的计算机和体外研究DOI: 10.1007/s10822-026-00785-7 Journal of molecular modeling IF: 02.500Volume 32, Issue 4No.194Quantum modeling of Stokes-Induced Stark Fields in quercetin-ZnO nanohybrids for bias-free bioelectric repair of chronic diabetic foot ulcers槲皮素-ZnO纳米杂化物中Stokes诱导斯塔克场的量子建模用于慢性糖尿病足溃疡的无偏生物电修复DOI: 10.1007/s00894-026-06693-9 Clinical Research in Cardiology IF: 03.700Ahead of Print.No.195Impact of the invasively measured flow-gradient pattern on clinical outcomes and ventricular remodeling after transcatheter aortic valve implantation in patients with severe aortic stenosis and preserved ejection fraction射血分数保留的重度主动脉瓣狭窄患者经导管主动脉瓣置换术后，有创测量的血流梯度模式对临床终点及心室重构的影响DOI: 10.1007/s00392-026-02881-y Clinical Research in Cardiology IF: 03.700Ahead of Print.No.196Impact of residential noise pollution on early-onset myocardial infarction risk results from the DECIBEL-MI (Determination of Environmental CIty-noise's Burden, Exposure, and Link to Myocardial Infarction) study居住噪声污染对早发性心肌梗死风险的影响——DECIBEL-MI研究结果DOI: 10.1007/s00392-026-02902-w Clinical Research in Cardiology IF: 03.700Ahead of Print.No.197Impact of catheter ablation for atrial fibrillation on cardiac ventricular electrical activity: assessment of premature ventricular complex burden导管消融对心房颤动的心脏心室电活动的影响：室性早搏负荷评估DOI: 10.1007/s00392-026-02906-6 Inflammopharmacology IF: 05.300Ahead of Print.No.198Enhanced wound healing in diabetic rats using Boswellia serrata Roxb.- Zn gel: a multifunctional approach targeting inflammation, oxidative stress, and tissue regeneration使用乳香提取物-锌凝胶增强糖尿病大鼠伤口愈合：针对炎症、氧化应激和组织再生的多功能方法DOI: 10.1007/s10787-026-02214-5 Infectious diseases and therapy IF: 05.300Ahead of Print.No.199Respiratory Syncytial Virus Immunization Strategies for Older Adults in Gulf Cooperation Council Countries: Expert Consensus and Recommendations海湾合作委员会国家老年人呼吸道合胞病毒免疫策略：专家共识与建议DOI: 10.1007/s40121-026-01313-8 J Muscle Res Cell Motil IF: 01.700Volume 47, Issue 2No.200Effects of culture media glucose concentration on LHCN-M2 skeletal muscle cell viability, differentiation and metabolic phenotype: a proof-of-concept study培养基葡萄糖浓度对LHCN-M2骨骼肌细胞活力、分化及代谢表型的影响：一项概念验证研究DOI: 10.1007/s10974-026-09729-y Pancreas IF: 01.700Ahead of Print.No.201Whole Metagenomic Profiling Identifies a Gut Microbial Signature for Chronic Pancreatitis via Machine Learning全宏基因组分析通过机器学习识别慢性胰腺炎的肠道微生物特征DOI: 10.1097/MPA.0000000000002618 Kidney360 IF: 03.000Volume 7, Issue 3No.202Erosion of Immune Regulation in Diabetic Kidney Disease糖尿病肾病中免疫调节的侵蚀DOI: 10.34067/KID.0000001182 Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.203The ABOARD-RWD infrastructure: Using linked real-world data to study the diagnosis and management of dementiaABOARD-RWD基础设施：利用链接的真实世界数据研究痴呆症的诊断与管理DOI: 10.1177/13872877261429858 Alcohol and alcoholism : IF: 02.200Volume 61, Issue 3No.204Moderate-to-heavy habitual alcohol use appears to be detrimentally associated with inflammation even when accounting for diet quality in humans: findings from an observational intensive longitudinal study中度至重度习惯性饮酒即使在考虑饮食质量时也与炎症呈不利关联：一项观察性强化纵向研究的结果DOI: 10.1093/alcalc/agag015 The Journal of school health IF: 01.800Volume 96, Issue 5No.205Evaluation of the Impact of a Psychoeducational Program on Type 1 Diabetes in Italian Schools: A Pre-Post Study评估心理教育项目对意大利学校1型糖尿病的影响：一项前后测研究DOI: 10.1111/josh.70141 The Journal of rural health IF: 02.700Volume 42, Issue 2No.206Barriers to consulting for symptoms of possible colorectal cancer among rural patients in England: A cross-sectional survey英格兰农村患者对可能结直肠癌症状咨询的障碍：一项横断面调查DOI: 10.1111/jrh.70142 Advanced materials IF: 26.800Ahead of Print.No.207AI-Guided 4D Printing of Carnivorous Plants-Inspired Microneedles for Accelerated Wound HealingAI引导的4D打印受食肉植物启发的微针用于加速伤口愈合DOI: 10.1002/adma.202523665 Wound repair and regeneration IF: 03.400Volume 34, Issue 2No.208Comparative Efficacy of Platelet-Rich Plasma, Platelet-Rich Fibrin, and Conventional Therapy in Chronic Non-Healing Skin Ulcers: A Randomised Clinical Trial富血小板血浆、富血小板纤维蛋白与常规治疗在慢性难愈性皮肤溃疡中的比较有效性：一项随机临床试验DOI: 10.1111/wrr.70151 Nephrol Dial Transplant IF: 05.600Ahead of Print.No.209Better cardiorenal protection for patients with CKD and type 1 diabetes对慢性肾病合并1型糖尿病患者更好的心肾保护DOI: 10.1093/ndt/gfag076 J Am Coll Surg IF: 03.400Ahead of Print.No.210Unraveling Metabolic Syndrome解读代谢综合征DOI: 10.1097/XCS.0000000000001952 J Prim Care Community Health IF: 02.500Volume 17, Issue No.211Self-Reported Depression, Anxiety, Stress, Health-Related Quality of Life, and Diabetes Distress During a 2-Year Pedometer-Based Physical Activity Intervention in Prediabetes and Type 2 Diabetes: Secondary Outcomes of a Randomized Controlled Trial针对前驱糖尿病和2型糖尿病患者的为期2年基于计步器的体力活动干预中自我报告的抑郁、焦虑、压力、健康相关生活质量及糖尿病困扰：随机对照试验的次要结局DOI: 10.1177/21501319261434134 Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.212NBL1 Associates with Renal Phenotypes in Mice, but Partial Nbl1 Reduction Does Not Ameliorate Kidney DiseaseNBL1与小鼠肾脏表型相关，但部分Nbl1减少并不能改善肾脏疾病DOI: 10.1152/ajprenal.00465.2025 J Geriatr Psychiatry Neurol IF: 02.500Ahead of Print.No.213The Role of Posttraumatic Stress Disorder as a Risk Factor for Dementia: A Meta-Analysis创伤后应激障碍作为痴呆风险因素的作用：一项荟萃分析DOI: 10.1177/08919887261435186 Pancreas IF: 01.700Ahead of Print.No.214Longitudinal Study of Comorbidities and Clinical Outcomes in Persons With Pancreatic Disease Using Electronic Health Records使用电子健康记录对胰腺疾病患者的合并症及临床结局进行纵向研究DOI: 10.1097/MPA.0000000000002636 East Mediterr Health J IF: 01.900Volume 32, Issue 3No.215The urgency of addressing the physical inactivity crisis in the Eastern Mediterranean Region解决东地中海地区体力不活动危机的紧迫性DOI: 10.26719/2026.32.3.127 Gut microbes reportsVolume 2, Issue 1No.216Alterations in gut microbiota characteristics along a type 2 diabetes risk gradient linked with family history与家族史相关的2型糖尿病风险梯度中肠道菌群组成DOI: 10.1080/29933935.2025.2527766 Gut microbes reportsVolume 2, Issue 1No.217Toxic metals impact gut microbiota and metabolic risk in five African-origin populations非洲起源个体中的有毒金属暴露、肠道微生物群与心脏代谢风险DOI: 10.1080/29933935.2025.2481442 Frontiers in big data IF: 02.300Volume 9, Issue No.218FunduScope: a human-centered, machine learning-based interactive tool for training junior ophthalmologists in diabetic retinopathy detectionFunduScope：一种以人为主导、基于机器学习的交互式工具，用于培训初级眼科医生进行糖尿病视网膜病变检测DOI: 10.3389/fdata.2026.1676922 Food Science and Biotechnology IF: 03.100Volume 35, Issue 5No.219Multifaceted role of plant polyphenols in human health: a comprehensive review植物多酚在人类健康中的多方面作用：综述DOI: 10.1007/s10068-025-01991-z Curēus IF: 01.300Volume 18, Issue 2No.220When Drainage is Not Enough in Emphysematous Pyelonephritis Complicated by Necrotizing Fasciitis: A Case Report气肿性肾盂肾炎并发坏死性筋膜炎时引流不足：一例报告DOI: 10.7759/cureus.104189 Journal of Cardiac Failure IF: 08.200Ahead of Print.No.221Fat Distribution and Postural Changes in Pulmonary Capillary Wedge Pressure in Patients with Obesity and HFpEF肥胖和射血分数保留的心力衰竭（HFpEF）患者的脂肪分布与肺毛细血管楔压的体位变化DOI: 10.1016/j.cardfail.2026.03.029 JACC: Clinical Electrophysiology IF: 07.700Ahead of Print.No.222The Liraglutide Effects in Atrial Fibrillation (LEAF) Study利拉鲁肽对心房颤动（LEAF）研究的影响DOI: 10.1016/j.jacep.2026.03.026 World journal of surgery IF: 02.500Ahead of Print.No.223Enhanced Recovery After Surgery (ERAS) Protocol for Abdominal Wall Reconstruction. A Scoping Review of Items Included in Current Protocols腹部重建术后的加速康复（ERAS）方案：当前方案中包含项目的范围综述DOI: 10.1002/wjs.70356 Diabetic medicine IF: 03.400Ahead of Print.No.224'Darkness as we face the unknown': Biopsychosocial-spiritual experiences of parents of children and young people with type 1 diabetes from the Middle East and North Africa (MENA) region面对未知的黑暗：中东和北非（MENA）地区患有1型糖尿病的儿童和青少年的父母的生物-心理-社会-精神体验DOI: 10.1111/dme.70303 Journal of neurochemistry IF: 04.000Volume 170, Issue 4No.225How Glutamate and GABA «Became» Neurotransmitters: Personal Account of a 65 Years' Voyage谷氨酸和GABA如何“成为”神经递质：一位研究者65年的历程自述DOI: 10.1111/jnc.70325 Clinical endocrinology IF: 02.400Ahead of Print.No.226Apparent Bilateral Aldosterone Suppression During Adrenal Vein Sampling: An Artefact of the Liaison Chemiluminescence Immunoassay and Other Causes Revealed by Comparisons With Another Commercial Immunoassay and Mass Spectrometry肾上腺静脉取样期间的明显双侧醛固酮抑制：Liaison化学发光免疫分析法的假象及与另一种商业免疫分析法和质谱法比较揭示的其他原因DOI: 10.1111/cen.70135 World J Biol Psychiatry IF: 03.800Ahead of Print.No.227Effect of appetite hormone dysregulation on symptom trajectory in adolescents with attention deficit hyperactivity disorder: an exploratory prospective study食欲激素失调对青少年注意力缺陷多动障碍症状轨迹的影响：一项探索性前瞻性研究DOI: 10.1080/15622975.2026.2646508 ANZ journal of surgery IF: 01.600Ahead of Print.No.228Patient Reported Outcomes After Total Pancreatectomy With Islet Autotransplantation: A Narrative Review全胰腺切除联合胰岛自体移植术后患者报告结局：一项叙事综述DOI: 10.1111/ans.70638 Ann Agric Environ Med IF: 01.200Volume 33, Issue 1No.229Multifactorial influence of type 2 diabetes on cardiovascular risk assessed by PolSCORE, SCORE2 in the age group 40-69 years2型糖尿病对40-69岁人群心血管风险的多因素影响（PolSCORE与SCORE2评估）DOI: 10.26444/aaem/205804 Pediatric obesity IF: 02.700Volume 21, Issue 4No.230Metabolic Complications and Ultrasound-Detected Liver Abnormalities in Paediatric Patients With Duchenne Muscular Dystrophy杜氏肌营养不良症患儿的代谢并发症及超声检测的肝脏异常DOI: 10.1111/ijpo.70106 Int J Soc Psychiatry IF: 02.700Ahead of Print.No.231Disordered Eating in Patients With Remission Schizophrenia: A Highly Prevalent but Largely Under-Explored Condition Despite Its Potential Relation to Psychopathology缓解期精神分裂症患者的进食障碍：一种高度流行但在很大程度上未被充分探索的疾病，尽管其可能与精神病理学相关DOI: 10.1177/00207640261424409 Gut microbes IF: 11.000Volume 18, Issue 1No.232Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction进食行为失调与针对进食障碍和食物成瘾的基于微生物群的干预措施DOI: 10.1080/19490976.2026.2647535 Pediatric obesity IF: 02.700Volume 21, Issue 4No.233Associations of Maternal Pre-Pregnancy BMI With Frontostriatal Connectivity in Young Children母亲孕前BMI与幼儿前额纹状体连接性的关联DOI: 10.1111/ijpo.70101 Medical science monitor IF: 02.100Volume 32, Issue No.234Social Attitudes Towards Public Health Interventions in Community Pharmacies in Poland: A Nationwide Cross-Sectional Survey波兰社区药房公共卫生干预措施的社会态度：全国横断面调查DOI: 10.12659/MSM.951732 Journal of neurochemistry IF: 04.000Volume 170, Issue 4No.235Cocaine-Induced Immediate-Early Gene Expression in the Nucleus Accumbens: Roles of Separate cAMP Sensors可卡因诱导伏隔核中即早基因表达：不同cAMP传感器的作用DOI: 10.1111/jnc.70374 Aust N Z J Obstet Gynaecol IF: 01.700Volume 66, Issue 2No.236Perinatal Outcomes After Sleeve Gastrectomy Compared to a Matched Control Group减重手术后妊娠的围产期结局与匹配对照组比较DOI: 10.1111/ajo.70117 Wound repair and regeneration IF: 03.400Volume 34, Issue 2No.237Autologous Blood Clot Therapy for Wounds: Investigating the Chemotactic Effect on PBMCs and Fibroblasts in Diabetes自体血凝块疗法治疗伤口：研究其对糖尿病患者外周血单核细胞和成纤维细胞的趋化作用DOI: 10.1111/wrr.70153 European journal of neurology IF: 03.900Volume 33, Issue 4No.238Subjective Memory Impairment in the General Adult Population: Associations With Early-Life Cognition, Concurrent Objective Memory, Dementia Risk Factors普通成年人群中的主观记忆障碍：与早年认知、同期客观记忆及痴呆风险因素的关联DOI: 10.1111/ene.70556 European journal of pain IF: 03.400Volume 30europeanjournalofpain, Issue 4, Page e70252-e70262No.239Short-Term Sleep Disruption Does Not Modify Responses to Experimentally Induced Knee Pain in Healthy Individuals短期睡眠中断不会改变健康个体对实验性膝关节疼痛的反应DOI: 10.1002/ejp.70260 Ann Agric Environ Med IF: 01.200Volume 33, Issue 1No.240Effect of overweight and obesity on clinical course and prognosis in patients with acute coronary syndromes超重和肥胖对急性冠脉综合征患者临床进程及预后的影响DOI: 10.26444/aaem/213894 Journal of food science IF: 03.400Volume 91, Issue 4No.241A Critical Review of Antidiabetic Properties of Tempeh From Various Substrates各种底物发酵天贝的抗糖尿病特性批判性综述DOI: 10.1111/1750-3841.71014 Clinical toxicology IF: 03.300Ahead of Print.No.242Recommendations from the Clinical Toxicology Recommendations Collaborative on the administration of activated charcoal in acute oral overdose临床毒理学推荐协作组关于急性口服过量中毒中活性炭给药的建议DOI: 10.1080/15563650.2025.2609807 Hypertension IF: 08.200Ahead of Print.No.243Dietary Sodium-Regulated Plasma SVEP1 and Inverse Salt Sensitivity饮食钠调节的血浆SVEP1与反向盐敏感性DOI: 10.1161/HYPERTENSIONAHA.125.26827 Natural product research IF: 01.600Ahead of Print.No.244Harnessing mangroves for epigenetic therapies利用红树林进行表观遗传疗法DOI: 10.1080/14786419.2026.2649921 Brain : IF: 11.700Ahead of Print.No.245Synapse-associated neuropathological markers in Alzheimer disease阿尔茨海默病中突触相关的神经病理标志物DOI: 10.1093/brain/awag117 European Journal of Immunology IF: 03.700Volume 56, Issue 4No.246Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis系统性I型干扰素阻断可减轻银屑病临床前模型中的胰岛素抵抗DOI: 10.1002/eji.70160 The FASEB journal : IF: 04.200Volume 40, Issue 7No.247Obesity Disrupts H3K4me3-Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages肥胖破坏缺氧巨噬细胞中H3K4me3介导的乳酸积累和胞葬作用DOI: 10.1096/fj.202502626R Journal of health psychology IF: 02.200Ahead of Print.No.248Technology readiness associated with insulin pump and automated insulin delivery system use in young adults with type 1 diabetes与1型糖尿病青年成年人胰岛素泵及自动化胰岛素递送系统使用相关的技术准备度DOI: 10.1177/13591053261433230 Diabetic medicine IF: 03.400Ahead of Print.No.249Exploring inequities in access to diabetes technologies among children and young people with type 1 diabetes: Perspectives of parents and young people from ethnic minority groups and low socio-economic areas探索1型糖尿病儿童和青少年获取糖尿病技术的不平等：少数族裔及低社会经济区域群体父母与青少年的视角DOI: 10.1111/dme.70304 Medeniyet medical journal IF: 01.100Volume 41, Issue 1No.250Impact of SARS-CoV-2 Infection on Diabetic Ketoacidosis in Children with Newly Diagnosed Type-1 Diabetes: A Prospective Multicenter Study严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染对新诊断1型糖尿病儿童糖尿病酮症酸中毒的影响：一项前瞻性多中心研究DOI: 10.4274/MMJ.galenos.2026.55256 211 Diabetes Mellitus(DM) 糖尿病 103 Obesity 肥胖症 70 Insulin 胰岛素 32 Type 2 diabetes mellitus(T2DM) 2型糖尿病 18 Metformin 二甲双胍 16 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 13 Metabolic Syndrome 代谢综合征 13 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 8 Semaglutide 司美格鲁肽 8 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 7 Hypoglycemic Agents 降糖药 7 Diabetic Retinopathy 糖尿病视网膜病 5 Diabetic Foot 糖尿病足 5 Liraglutide 利拉鲁肽 4 Tirzepatide 替尔泊肽 3 Dulaglutide 度拉糖肽 3 Diabetes Complications 糖尿病并发症 2 Diabetic Cardiomyopathies 糖尿病心肌病 2 gamma-Aminobutyric Acid(GABA) γ-氨基丁酸 2 Gabapentin 加巴喷丁 2 Exenatide 艾塞那肽 2 Type 1 diabetes mellitus(T1DM) 1型糖尿病 1 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 1 Sitagliptin 西他列汀 1 Albiglutide 阿必鲁肽 1 Lixisenatide 利司那肽 1 Diabetic Peripheral Neuropathy(PDN) 糖尿病周围神经病变 1 Diabetic Neuropathies 糖尿病性神经病变 1 Diabetic acidosis 糖尿病性酸中毒 1 Bexagliflozin 贝沙格列净 1 Canagliflozin 卡格列净 1 Dapagliflozin 达格列净编辑：韩玉莲审校：韩玉莲

临床结果临床3期

2026-03-27

·榕创云际

小核酸药物：生物医药黄金赛道，奇点已至迎产业新篇

生物医药领域的创新迭代，始终在为人类疾病治疗打开新的大门。近年来，小核酸药物凭借独特的基因调控机制、突破传统制药的治疗边界，成为全球生物医药研发的核心热门赛道。2025年全球小核酸药物市场规模已突破71亿美元，同比激增39.9%，多款重磅产品实现商业化爆发，而国内企业也凭借高效的研发效率和本土化优势，在全球竞速中逐步占据主动。作为新一代创新药物，小核酸药物的崛起并非偶然，其背后是底层技术的持续突破和临床价值的充分验证。今天我们就来聊聊这一生物医药领域的“潜力赛道”，用硬核数据解读，它究竟凭什么成为全球药企的必争之地，又迎来了哪些发展新机遇。技术内核：重构治疗逻辑，解锁差异化核心优势小核酸药物的核心魅力，在于其从基因层面实现疾病的精准调控，这是传统小分子、抗体药物难以企及的。简单来说，小核酸是人工化学合成的15-25个核苷酸的短核酸序列，主要通过调控mRNA的转录、翻译过程，从上游直接干预致病蛋白的生成，从源头上解决疾病问题。目前主流的小核酸药物主要包括siRNA、ASO、适配体等类型，各有独特的作用机制，比如siRNA可通过降解靶标mRNA抑制蛋白表达，ASO能调控mRNA的剪接与降解。这一特性让它突破了传统药物的“不可成药”限制，理论上可针对任意基因进行调节，为众多难治性疾病的治疗提供了新方案。更值得关注的是，小核酸药物的临床开发成功率远超行业平均，成为药企研发的“效率利器”。以RNAi领域龙头Alnylam为例，其I期到II期临床成功率达85.7%，而行业整体仅35.2%；II期到III期成功率88.9%，是行业27.4%的3倍多；累计临床转化率更是达到64.4%，是医药行业整体5.7%的11倍，这一数据直接打破了创新药研发“九死一生”的魔咒。对比小分子、抗体药物，小核酸药物的差异化优势还体现在全维度：特异性更高，能精准靶向致病基因；给药周期更长，可实现每月、每季度甚至半年一次给药，大幅提升患者依从性；生产以化学合成为主，成本适中，且免疫原性低、药物相互作用小。而GalNAc等关键递送技术的成熟，更是解决了小核酸药物的组织靶向难题，推动其从最初的肝脏靶向，逐步向脑、脂肪、肾脏等肝外靶器官拓展，为适应症的全面爆发打开了空间。历经数十年发展，小核酸药物已走过奠基、探索、突破阶段，2020年以来进入加速发展期，从实验室走向临床，再到商业化落地，技术成熟度持续提升。市场图景：商业化提速，行业迈入高增长通道随着技术的成熟和临床验证的推进，全球小核酸药物市场已进入高速增长通道，商业化成果持续落地，产业热度居高不下，数据足以印证这一赛道的潜力。从市场规模来看，全球小核酸药物市场从2019年的27亿美元增长至2024年的57亿美元，年复合增长率达16.2%；2025年更是突破71.22亿美元，同比增长39.9%，实现跨越式增长。据行业权威预测，在技术进步、新适应症获批的双重推动下，这一赛道将继续保持高增速，2029年市场规模有望突破206亿美元（2024-2029年CAGR29.4%），2034年进一步攀升至549亿美元（2029-2034年CAGR21.6%），未来十年仍将是黄金增长期。商业化落地方面，截至2026年3月，全球获批的小核酸药物已达23款（含13款ASO、7款siRNA，3款因安全性或市场竞争退市），适应症从罕见病逐步向大众慢病拓展。而2025年底，已有三款小核酸药物正式迈入“十亿美元销售俱乐部”，成为生物医药领域的新晋重磅品种：Alnylam的Amvuttra以23.14亿美元销售额登顶，同比暴涨138.31%，成为小核酸领域首款20亿美金级单品；渤健的Spinraza稳守15.47亿美元；诺华的Leqvio实现11.98亿美元销售额，同比增长58.89%，三款产品的表现直接印证了小核酸药物的临床价值和市场潜力。与此同时，全球小核酸领域的合作与交易也持续升温，成为药企布局赛道的重要方式。2025年全球小核酸领域交易金额超322.1亿美元，交易数量达46起，海外龙头药企纷纷重金押注——诺华单年就以超200亿美元通过收购、授权等方式布局小核酸资产，礼来也接连达成超30亿美元合作聚焦代谢领域。从交易主体来看，转让方中Ionis以58项交易居首，Alnylam、Arrowhead分别以20项、11项紧随其后；受让方则以诺华（15项）、渤健（13项）、阿斯利康（11项）等跨国药企为主，足见行业对小核酸药物赛道的长期看好。适应症拓展：从罕见病到大领域，治疗边界持续突破小核酸药物的发展，正经历从罕见病向大众慢病、从单一靶器官向多器官靶向的重要转变，治疗边界不断被打破，覆盖领域越来越广，而各赛道的管线布局数据，也展现出这一领域的蓬勃生机。最初，小核酸药物主要聚焦于肝脏靶向的罕见病领域，解决了部分无药可医的临床需求。而如今，凭借递送技术的突破，小核酸药物已在心血管代谢、肾病、减重、肝炎、代谢相关脂肪性肝炎（MASH）等大适应症领域实现了全面布局，成为赛道增长的核心动力，各领域管线均呈爆发式增长：心血管代谢领域：高脂血症、高血压是目前布局最火热的赛道，全球超20款高脂血症小核酸管线在研，PCSK9、ANGPTL3、AGT等靶点成药潜力显著，齐鲁、石药等国内企业多款产品已进入III期临床，与海外进度基本同步；必贝特的BEBT-701更是国内首款AGT+PCSK9双靶点siRNA，为高血压合并高血脂患者提供了全新方案。肾病领域：IgA肾病成为核心研发方向，全球超15款管线在研，靶点以CFB、C3为主，罗氏的Sefaxersen是全球首款进入III期的小核酸药物，国内舶望制药、苏州圣因等企业的II期临床布局积极，有望填补肾病治疗的临床空白。减重与MASH：作为新一代热门赛道，减重领域聚焦ALK7、INHBE靶点，全球超10款管线进入I/II期；MASH领域靶向HSD17B13、PNPLA3靶点，Arrowhead、阿斯利康等海外企业推进II期，诺和诺德、再生元布局I期，国内成都先导、圣因生物等也已紧跟步伐。肝炎领域：乙肝、丁肝是国内研发的优势赛道，全球超30款相关管线在研，其中国内企业布局超20款，葛兰素史克的贝普若韦生已提交上市申请，有望成为首款获批的乙肝小核酸药物，腾盛博药、舶望制药、瑞博生物等国内企业的II期临床也表现突出。从罕见病到大众病，从单一领域到多领域覆盖，小核酸药物的临床价值不断被挖掘，未来还将在神经退行性疾病、肿瘤等更多难治性疾病领域实现突破。全球竞速：海外龙头领跑，国内企业迎突破良机目前全球小核酸药物赛道呈现海外龙头领跑，国内企业快速追赶的竞争格局，而国内企业凭借高效的临床开发效率、自主的技术平台和丰富的管线布局，正逐步在全球赛道中占据主动，迎来发展良机，一系列重磅动作更是让行业看到了中国创新的力量。海外龙头：平台化布局，构筑技术与商业化壁垒海外头部企业凭借多年的技术积累和先发优势，已形成成熟的技术平台和丰富的产品管线，成为赛道的引领者。 Alnylam作为RNAi领域的绝对龙头，不仅坐拥Amvuttra、Leqvio等多款重磅产品，2025年产品总收入达29.87亿美元，同比增长81%，还首次实现盈利3.14亿美元；其管线覆盖心血管、代谢、罕见病等多个领域，高血压药物齐贝司兰已进入III期，未来增长潜力巨大。Ionis是ASO疗法的领军者，旗下首款FCS治疗药物TRYNGOLZA上市首年即实现1.08亿美元收入，多款药物预计2026年公布III期数据。Arrowhead则凭借独特的TRiM递送平台，实现多器官靶向，在MASH、肥胖等赛道进展显著。这些企业的核心优势在于成熟的技术平台、完善的递送系统和全球化的商业化能力。国内企业：技术突破+管线拓展，实现从跟跑到并跑国内小核酸药物研发起步虽晚，但发展速度惊人，近年来在技术平台、递送系统、临床研发等方面均实现了关键突破，部分领域已与海外并跑，核心企业的动作更是频频出圈：技术自主化：瑞博生物打造了自主的RiboGalSTAR肝靶向递送技术，推动超10款产品进入临床，其中多款进入II期；还布局了RiboOncoSTAR、RiboPepSTAR等肝外递送技术，覆盖肾、中枢神经、脂肪等靶器官，实现技术自主可控。重磅合作出海：前沿生物与GSK达成超9.63亿美元的合作，获4000万美元首付款，将两款siRNA管线产品授权其全球开发，其中一款已进入IND阶段，成为国内小核酸管线最大规模海外授权之一，彰显了国内研发的硬实力。并购加码布局：中国生物制药以12亿元人民币全资收购赫吉亚，斩获全球首个可实现“一年一针”的MVIP肝靶向平台，赫吉亚目前已有4款产品进入临床阶段、20+项目处于临床前，管线覆盖减重代谢、心脑血管、神经系统三大慢病领域，助力中国生物制药在小核酸领域实现弯道超车。临床进度同步：舶望制药依托RADS平台，管线覆盖IgA肾病、乙肝、高脂血症，多款产品进入国内II期临床，与海外进度基本同步；靖因药业、成都先导、圣因生物等企业也在高血压、减重、肾病等领域布局了多款临床管线，形成了百花齐放的格局。如今，国内企业正从技术跟随向自主创新转变，凭借本土化的临床优势、高效的研发节奏和丰富的临床需求，在全球小核酸药物竞速中逐步掌握主动权。赛道展望：平台化成趋势，创新力量迎发展新机小核酸药物的发展，正从单一药物研发向平台化、多维化迈进，递送技术的持续创新、多靶点多器官的布局、大适应症的临床突破，将成为未来赛道发展的核心方向。而随着全球市场的持续增长——2025年71亿美元的市场规模只是起点，2034年有望突破500亿美元，叠加国内技术的不断突破，小核酸药物赛道将迎来更多发展机遇。在这一赛道中，拥有自主技术平台、成熟递送系统、丰富管线布局的企业将更具竞争优势，无论是海外的Alnylam、Ionis等龙头药企，还是国内的瑞博生物、舶望制药、前沿生物等创新力量，都将在这一黄金赛道中迎来新的发展空间。同时，国内企业也将凭借本土化优势，在临床开发、商业化落地等方面持续发力，成为全球小核酸药物产业发展的重要力量。当然，小核酸药物赛道仍处于发展阶段，行业发展也面临着研发不确定性、同靶点竞争、技术迭代等挑战，目前全球销售额最高的小核酸药物尚未突破30亿美元，距离百亿美元“药王”还有不小的距离，赛道的成长仍需要时间和临床验证。但不可否认的是，作为生物医药领域的新一代创新药物，小核酸药物的临床价值和市场潜力已得到充分印证，其未来的发展值得期待。生物医药的创新，始终是为了攻克难治性疾病，为人类健康带来新的希望。小核酸药物的崛起，正是这一创新浪潮的缩影。随着技术的持续突破和产业的不断成熟，这一赛道必将迎来更多惊喜，也将为生物医药产业的发展注入新的活力。【温馨提示】：本文内容基于公开行业信息整理而成，仅作生物医药领域的科普与交流使用，不构成任何投资建议、医疗决策建议及其他商业决策依据。文中所提及的企业、技术、产品等信息，均为行业客观信息梳理，不代表对任何主体的推荐、认可或评价。任何单位或个人依据本文内容所做出的任何决策，均由其自行承担相应风险与责任。关注我，后续会持续和大家聊聊各赛道的发展趋势，一起在行业变化中，看清背后的底层逻辑～公众号私信回复：13190327，领取特斯拉机器人相关思维导图 #小核酸药物#创新药#CXO

100 项与奥莱扎森相关的药物交易

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研发状态

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适应症	国家/地区	公司	日期
高甘油三酯血症	加拿大	Ionis Pharmaceuticals, Inc.	2025-12-01
家族性乳糜微粒血症综合征	美国	Ionis Pharmaceuticals, Inc.	2024-12-19

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10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
I型高脂蛋白血症	临床3期	荷兰	Ionis Pharmaceuticals, Inc.	2020-12-21
IV型高脂蛋白血症	临床3期	荷兰	Ionis Pharmaceuticals, Inc.	2020-12-21

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临床结果

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04568434 (Balance, Pubmed \| J Clin Lipidol)	临床3期	家族性乳糜微粒血症综合征	65	Olezarsen 80 mg	構廠餘顧繭獵廠憲顧選(繭襯範鏇鏇憲襯淵願簾): RR = 0.16 (95.0% CI, 0.05 ~ 0.5) 更多	积极	2025-12-01
				Placebo
NCT05552326 \| NCT05079919 (CORE2 \| CORE2-TIMI 72b, Company_Website \| Pubmed \| N Engl J Med) 人工标引	临床3期	高甘油三酯血症	1,061	Olezarsen 50 mgOlezarsen 50 mg	積壓壓鬱膚糧製壓醖壓(鑰憲製遞構繭憲衊範繭) = The reductions were sustained through 12 months. 艱鹽築繭鬱鹽衊鹹鹽繭 (餘廠餘蓋選鬱糧選願遞 ) 达到更多	积极	2025-11-08
				OlezarsenOlezarsen 80 mg
NCT05610280 (ESSENCE-TIMI 73b, Pubmed \| N Engl J Med) 人工标引	临床3期	高甘油三酯血症	1,349	Olezarsen 50 mg	觸鑰製繭範製網窪壓顧(製鏇餘壓繭網鏇鏇壓窪) = 淵觸積窪築淵範獵觸淵餘鹽選蓋憲製鏇選餘廠 (繭憲齋鏇鬱襯糧願齋獵 )	积极	2025-10-02
				Olezarsen 80 mg	觸鑰製繭範製網窪壓顧(製鏇餘壓繭網鏇鏇壓窪) = 齋齋餘願鹽繭簾顧顧鏇餘鹽選蓋憲製鏇選餘廠 (繭憲齋鏇鬱襯糧願齋獵 )
NCT05552326 \| NCT05079919 (CORE2, Company_Website \| NEWS) 人工标引	临床3期	高甘油三酯血症	1,063	Olezarsen 80 mg (CORE study)	構範蓋製簾鑰範壓憲積(構積醖壓壓願壓鑰繭鏇) = 艱艱簾壓網鏇鑰顧襯衊構範顧遞顧顧齋觸夢獵 (獵顧糧夢糧製糧顧製鑰 ) 达到更多	积极	2025-09-02
				Olezarsen 50 mg (CORE study)	構範蓋製簾鑰範壓憲積(構積醖壓壓願壓鑰繭鏇) = 簾鑰簾淵願憲鏇範簾築構範顧遞顧顧齋觸夢獵 (獵顧糧夢糧製糧顧製鑰 ) 达到更多
NCT05610280 (ESSENCE-TIMI 73b, NEWS \| ESC2025) 人工标引	临床3期	高甘油三酯血症	1,349	Olezarsen 50 mg	憲構醖憲繭憲蓋淵膚製(膚廠衊膚築憲憲窪範鬱) = 積蓋廠壓構廠壓顧壓糧繭製選鏇醖簾淵願顧憲 (壓顧鏇積齋鏇築餘觸淵 ) 更多	积极	2025-08-31
				Olezarsen 80 mg	憲構醖憲繭憲蓋淵膚製(膚廠衊膚築憲憲窪範鬱) = 積窪構積遞鏇廠製襯衊繭製選鏇醖簾淵願顧憲 (壓顧鏇積齋鏇築餘觸淵 ) 更多
NCT05552326 \| NCT05079919 (CORE-TIMI 72a \| CORE2-TIMI 72b, Pubmed \| Am Heart J)	临床3期	高甘油三酯血症 mRNA for apolipoprotein C-III	-	Olezarsen 80 mg	餘齋築願網網選醖鬱衊(夢蓋繭壓廠壓夢繭鹽夢) = 壓簾夢糧獵膚齋製夢齋窪網壓鏇顧淵壓範鹹憲 (餘醖構遞醖簾蓋網選鹹 )	积极	2025-08-01
				Olezarsen 50 mg	餘齋築願網網選醖鬱衊(夢蓋繭壓廠壓夢繭鹽夢) = 鹽積積選遞壓鑰襯鹹繭窪網壓鏇顧淵壓範鹹憲 (餘醖構遞醖簾蓋網選鹹 )
NCT05610280 (Essence, PipelineReview) 人工标引	临床3期	高甘油三酯血症 \| 动脉粥样硬化	-	Olezarsen 50 mg	糧繭艱觸齋製淵範鹹鬱(選廠艱艱蓋艱範觸繭獵) = 夢網衊積憲繭壓廠襯膚淵齋衊範蓋積鏇鬱壓夢 (壓鏇鹽鏇壓鏇衊醖衊願 ) 达到	积极	2025-05-20
				Olezarsen 80 mg	糧繭艱觸齋製淵範鹹鬱(選廠艱艱蓋艱範觸繭獵) = 憲遞願觸製鹽艱艱鏇醖淵齋衊範蓋積鏇鬱壓夢 (壓鏇鹽鏇壓鏇衊醖衊願 ) 达到
NCT04568434 (BALANCE, CTgov)	临床3期	家族性乳糜微粒血症综合征	66	Placebo (Placebo)	餘製餘網簾廠淵窪鹹顧(艱衊鑰網鏇糧齋廠衊遞) = 獵鹹繭淵選獵願繭積構鑰範窪獵衊蓋鏇艱膚願 (膚鬱顧夢醖醖糧簾鏇積, 鑰繭窪顧觸範製獵壓獵 ~ 鹽願衊襯窪簾膚衊簾鏇) 更多	-	2025-03-06
				Olezarsen (Olezarsen 50 mg)	餘製餘網簾廠淵窪鹹顧(艱衊鑰網鏇糧齋廠衊遞) = 廠願觸窪簾鏇夢衊膚淵鑰範窪獵衊蓋鏇艱膚願 (膚鬱顧夢醖醖糧簾鏇積, 襯夢鏇膚襯壓蓋廠獵衊 ~ 觸鹹壓壓鬱觸築遞願餘) 更多
NCT04568434 (BALANCE, FDA_CDER) 人工标引	临床3期	家族性乳糜微粒血症综合征	45	TRYNGOLZA	繭鹽餘築夢獵窪艱膚鑰(網鏇鹹餘憲襯齋願膚膚) = 鏇鹹築網蓋築鏇壓膚選鹽鏇憲艱膚構壓齋壓遞 (壓繭醖範窪蓋鏇憲醖顧 ) 更多	积极	2024-12-19
				Placebo	繭鹽餘築夢獵窪艱膚鑰(網鏇鹹餘憲襯齋願膚膚) = 積選簾製壓窪夢襯蓋觸鹽鏇憲艱膚構壓齋壓遞 (壓繭醖範窪蓋鏇憲醖顧 ) 更多
Balance Trial (ENDO2024)	临床3期	家族性乳糜微粒血症综合征 apolipoprotein C-III	66	Olezarsen 80 mg	憲壓憲鹽鏇膚築繭簾廠(鹹積觸構鹹廠網齋願願) = 夢窪構壓獵顧壓獵齋積鏇鑰顧蓋壓壓艱壓遞糧 (願齋淵網醖憲範鑰窪構 ) 更多	积极	2024-06-01
				Olezarsen 50 mg	憲壓憲鹽鏇膚築繭簾廠(鹹積觸構鹹廠網齋願願) = 願積鏇襯艱窪鬱願醖衊鏇鑰顧蓋壓壓艱壓遞糧 (願齋淵網醖憲範鑰窪構 ) 更多