Olezarsen Sodium

编者按：寡核苷酸药物已成为全球新药开发的重要热点，近年来在多个领域获得快速应用。为帮助合作伙伴更高效地推动寡核苷酸药物从实验室走向临床，药明康德围绕寡核苷酸及其相关化学偶联药物构建了一体化解决方案，覆盖定制合成、共价连接、工艺开发以及CMC等关键环节，为寡核苷酸及复杂偶联药物的发现与开发提供有力支持。本文将盘点2026年第一季度寡核苷酸领域的重要进展，带您了解这一快速发展领域的最新动态与趋势。 多款疗法递交上市申请，寡核苷酸进展横跨罕见病与常见疾病 2026年第一季度，多款寡核苷酸疗法在罕见疾病领域持续取得监管突破。例如，欧盟委员会（EC）在1月批准Dawnzera（donidalorsen）在欧盟上市，用于成人及12岁以上青少年遗传性血管性水肿（HAE）反复发作的常规预防。Dawnzera是一款反义寡核苷酸配体偶联（LICA）药物，旨在通过沉默前激肽释放酶（PKK）的表达，中断导致HAE发作的相关信号通路。在OASISplus开放标签延长期研究中，用药一年后患者的总体平均月发作率降低达94%。 与此同时，Ionis Pharmaceuticals用于治疗亚历山大病（AxD）的反义寡核苷酸（ASO）疗法zilganersen（ION373）也在本季度迎来监管进展。该疗法的新药申请（NDA）已获美国FDA受理，并被授予优先审评资格，PDUFA日期为2026年9月22日。AxD是一种罕见、进行性且最终致命的神经系统疾病。研究显示，在儿童及成人AxD患者中，50 mg zilganersen在第61周时相较对照组，在主要终点10米步行测试（10MWT）评估的步行速度方面实现了具有统计学意义且临床意义明确的稳定效果（最小二乘均值差异33.3%，P=0.0412），同时展现出良好的安全性和耐受性。 在临床研究方面，Wave Life Sciences旗下ASO疗法WVE-N531在FORWARD-53 2期临床研究中也取得积极进展。数据显示，接受治疗的杜氏肌营养不良症（DMD）患者在24至48周期间，经肌肉含量校正后的肌营养不良蛋白表达水平保持稳定，平均达到7.8%。肌肉组织学分析进一步显示，肌纤维从再生阶段向成熟阶段转变，同时肌肉纤维化显著减少（24至48周期间降低28.6%；p<0.01）。该公司计划于今年向美国FDA递交新药申请，寻求WVE-N531的加速批准。 除了罕见病领域，寡核苷酸疗法在常见疾病中的应用也在不断取得突破。FDA在本季度受理Ionis旗下ASO疗法olezarsen用于治疗严重高甘油三酯血症（sHTG）的补充新药申请（sNDA），并授予优先审评资格。该申请的PDUFA日期设定为2026年6月30日。研究数据显示，olezarsen可实现最高达72%的安慰剂校正甘油三酯水平降低，同时急性胰腺炎事件减少85%，并表现出良好的安全性和耐受性。此外，近90%接受olezarsen治疗的患者甘油三酯水平降至500 mg/dL以下，低于急性胰腺炎的风险阈值。这些结果表明，该疗法不仅能够显著降低甘油三酯水平，也有望降低与严重高甘油三酯血症相关的临床风险。 在疫苗领域，Moderna也在推进其mRNA技术平台的应用。该公司在2月与美国FDA就其季节性流感疫苗候选产品mRNA-1010的修订申报策略达成共识。根据更新后的计划，Moderna将为50至64岁成年人申请完全批准，并为65岁及以上成年人寻求加速批准。在提交修订申请后，FDA已正式受理该生物制品许可申请（BLA），并设定2026年8月5日为目标审评完成日期。mRNA-1010是一款基于mRNA技术的季节性流感疫苗，旨在针对流感A型和B型多种毒株提供更广泛且更高效的免疫保护。 在肝炎领域，寡核苷酸疗法也迎来新的监管进展。日本厚生劳动省（MHLW）已受理Ionis与GSK联合开发的潜在“first-in-class”ASO疗法bepirovirsen的新药申请，用于治疗成人慢性乙型肝炎（CHB）。这是该疗法在全球范围内首次向监管机构递交上市申请。Bepirovirsen是一种具有三重作用机制的ASO疗法，可识别并靶向乙肝病毒的遗传成分（即RNA），从而帮助患者免疫系统重新获得对病毒感染的控制能力。研究显示，与单纯标准治疗相比，bepirovirsen联合标准治疗在所有预设层级终点中均实现更高的功能性治愈率，且差异具有统计学意义和临床意义。 与此同时，Wave Life Sciences还公布了其长效GalNAc修饰siRNA疗法WVE-007在INLIGHT首次人体试验（1期部分）的最新数据。随访6个月结果显示，单次240 mg给药即可持续改善超重或肥胖患者的身体成分结构，在减少脂肪的同时实现肌肉保留。此外，WVE-007还能够持续、剂量依赖性地抑制血清靶蛋白水平，这一效应至少可维持7个月，为每年一次或两次给药提供了依据。 另一家企业Tangram Therapeutics则在本季度完成其主打候选药物TGM-312的1/2期临床试验首例受试者给药。TGM-312是一种基于Tangram专有RNAi化学平台GalOmic开发的GalNAc-siRNA疗法，旨在特异性沉默肝细胞中的一个新靶点基因，用于治疗代谢功能障碍相关脂肪性肝炎（MASH）。该药物有望实现每季度一次的皮下给药，从而提升患者的用药便利性。 多家大药企达成上亿美元寡核苷酸疗法合作 在产业合作方面，多家大型制药企业在本季度达成多项规模可观的寡核苷酸合作交易。今年2月，罗氏（Roche）旗下基因泰克（Genentech）与圣因生物（SanegeneBio）达成全球研发合作与许可协议，双方将基于圣因生物专有的RNA干扰（RNAi）药物研发平台共同推进一款RNAi疗法的开发。根据协议条款，圣因生物将获得2亿美元首付款，并有权收取开发和销售里程碑付款，总金额最高可达15亿美元。该公司平台整合了新型药物化学修饰与递送技术，其中包括具有组织选择性的LEAD肝外递送技术，可支持多个疾病领域具有“best-in-class”或“first-in-class”潜力的RNAi药物开发。 同月，Madrigal Pharmaceuticals也与瑞博生物及其子公司Ribocure Pharmaceuticals达成最高达44亿美元的全球独家许可协议。双方将基于瑞博生物的肝靶向RiboGalSTAR平台，共同开发6款针对MASH的创新siRNA疗法。此外，GSK与前沿生物（Frontier Biotechnologies）也达成超过10亿美元的合作。根据协议，GSK将获得两款siRNA管线产品在全球范围内的独家开发、生产及商业化权利，其中一款候选药物已进入新药临床试验申请（IND）阶段，另一款仍处于临床前研究阶段。 与此同时，礼来（Eli Lilly and Company）也与Orna Therapeutics达成收购协议，交易金额最高可达24亿美元。Orna正在推进其细胞疗法平台，该平台基于工程化环状RNA，并结合新型脂质纳米颗粒技术，使患者自身能够在体内生成具有治疗作用的免疫细胞，从而靶向疾病的根本机制。Orna的主打项目为ORN-252，这是一款即将进入临床试验的体内CD19靶向嵌合抗原受体T细胞（CAR-T）疗法，拟用于治疗由B细胞驱动的自身免疫性疾病。 由以上进展可以发现，本季度多项大型交易均围绕siRNA疗法展开。而在siRNA药物快速发展的背景下，如何通过体外研究准确预测其体内代谢行为，是核酸药物研发中的关键科学挑战之一。由于siRNA在体内主要经历核酸酶介导的逐步降解，其代谢过程高度依赖生物环境差异，传统体外模型往往难以真实反映体内代谢路径，进而影响候选分子的评价与开发效率。为满足客户的持续需求，药明康德DMPK团队通过系统性研究与方法论优化，建立了能够显著提升体外-体内相关性（IVIVC）的siRNA代谢评价体系，为体外模型预测能力提供了坚实的科学基础。  基于对代表性GalNAc偶联siRNA药物inclisiran的深入研究，团队系统比较了多种体外模型在模拟体内血液与肝脏代谢方面的表现，包括血清、不同抗凝条件下的血浆、肝匀浆、S9组分、tritosomes及贴壁肝细胞等模型，并结合体内数据验证其预测能力。研究结果表明，经肝素抗凝处理的血浆与血清能够较好模拟体内血液中的核酸酶代谢，而在肝脏代谢方面，特定pH条件下的肝匀浆、tritosomes以及优化培养条件下的肝细胞模型可有效重现体内代谢特征，从而显著提升体外研究对体内结果的预测准确性。此外，研究还发现实验条件如缓冲体系与pH值对代谢结果具有关键影响，强调了针对siRNA分子特性进行模型优化的重要性。  药明康德DMPK团队已经构建了涵盖血液、亚细胞组分及细胞模型的多层级体外代谢研究平台，可系统解析siRNA在循环系统与靶组织中的降解路径及代谢特征，并支持跨物种比较以提高临床转化可靠性。通过将机制研究与标准化实验流程相结合，该能力帮助研发团队更早识别代谢风险、优化分子设计策略，并降低从体外研究到体内验证过程中的不确定性，为siRNA药物高效迈向临床开发提供关键支撑。 Multiple Billion-Dollar siRNA Partnerships and Regulatory Breakthroughs Signal New Progress in Oligonucleotide Therapies  Editor’s Note: Oligonucleotide therapeutics have become a major focus of global drug development and have seen rapid adoption in recent years across multiple therapeutic areas. To help partners more efficiently advance oligonucleotide drugs from the laboratory to the clinic, WuXi AppTec has built an integrated solution centered on oligonucleotides and related chemically conjugated modalities. This solution covers key stages including custom synthesis, covalent conjugation, process development, and CMC, providing strong support for the discovery and development of oligonucleotides and complex conjugated drugs. This article reviews major developments in the oligonucleotide field in the first quarter of 2026 and highlights the latest trends in this rapidly evolving area. Multiple Therapies File for Approval as Oligonucleotide Advances Span Rare and Common Diseases In the first quarter of 2026, several oligonucleotide therapies continued to achieve regulatory breakthroughs in rare diseases. For example, in January the European Commission approved Dawnzera (donidalorsen) in the European Union for routine prevention of recurrent attacks of hereditary angioedema (HAE) in adults and adolescents aged 12 years and older. Dawnzera is a ligand-conjugated antisense oligonucleotide (LICA) designed to interrupt signaling pathways that trigger HAE attacks by silencing the expression of prekallikrein (PKK). In the OASISplus open-label extension study, the overall average monthly attack rate decreased by 94% after one year of treatment. Meanwhile, an antisense oligonucleotide (ASO) therapy developed by Ionis Pharmaceuticals for Alexander disease (AxD), zilganersen (ION373), also reached an important regulatory milestone this quarter. Its New Drug Application (NDA) has been accepted by the U.S. Food and Drug Administration and granted Priority Review, with a PDUFA date set for September 22, 2026. AxD is a rare, progressive, and ultimately fatal neurological disease. Studies showed that in both pediatric and adult AxD patients, 50 mg zilganersen demonstrated a statistically and clinically meaningful stabilization in walking speed at Week 61 as measured by the 10-meter walk test (10MWT) compared with the control group (least squares mean difference 33.3%, P=0.0412), while also showing good safety and tolerability. In clinical development, the ASO therapy WVE-N531 from Wave Life Sciences also reported positive progress in the Phase 2 FORWARD-53 study. Data showed that in patients with Duchenne muscular dystrophy (DMD), dystrophin expression adjusted for muscle content remained stable at an average of 7.8% between Weeks 24 and 48. Histological analyses further demonstrated that muscle fibers transitioned from regeneration to maturation, while muscle fibrosis significantly decreased (28.6% reduction from Weeks 24 to 48; p<0.01). The company plans to submit an NDA to the U.S. FDA this year seeking accelerated approval for WVE-N531. Beyond rare diseases, oligonucleotide therapies are also making progress in more common conditions. The FDA accepted a supplemental New Drug Application (sNDA) this quarter for the Ionis ASO therapy olezarsen for the treatment of severe hypertriglyceridemia (sHTG), granting Priority Review. The PDUFA date is set for June 30, 2026. Data show that olezarsen achieved up to a 72% placebo-adjusted reduction in triglyceride levels, while reducing acute pancreatitis events by 85% and demonstrating favorable safety and tolerability. Additionally, nearly 90% of patients receiving olezarsen achieved triglyceride levels below 500 mg/dL, which is lower than the risk threshold for acute pancreatitis. These findings suggest that the therapy not only significantly lowers triglycerides but may also reduce clinical risks associated with sHTG. In the vaccine field, Moderna is also advancing applications of its mRNA technology platform. In February, the company reached agreement with the U.S. FDA on a revised regulatory submission strategy for its seasonal influenza vaccine candidate mRNA-1010. Under the updated plan, Moderna will seek full approval for adults aged 50 to 64 and accelerated approval for adults aged 65 and older. Following submission of the revised application, the FDA accepted the Biologics License Application (BLA) and set a target review completion date of August 5, 2026. mRNA-1010 is an mRNA-based seasonal influenza vaccine designed to provide broader and more effective immune protection against multiple influenza A and B strains. In the hepatitis field, oligonucleotide therapies have also achieved regulatory progress. The Ministry of Health, Labour and Welfare in Japan has accepted the NDA for the potential first-in-class ASO therapy bepirovirsen, jointly developed by Ionis and GSK, for the treatment of adults with chronic hepatitis B (CHB). This marks the first global regulatory filing for the therapy. Bepirovirsen is an ASO therapy with a triple mechanism of action that recognizes and targets the genetic components (RNA) of the hepatitis B virus, potentially enabling patients’ immune systems to regain control over the infection. Studies showed that compared with standard of care alone, bepirovirsen combined with standard therapy achieved higher functional cure rates across all prespecified hierarchical endpoints, with statistically and clinically significant differences. Wave Life Sciences also reported new data from the first-in-human trial (Phase 1 portion) of its long-acting GalNAc-modified siRNA therapy WVE-007 in the INLIGHT study. Six-month follow-up results showed that a single 240 mg dose produced sustained improvements in body composition in overweight or obese individuals, reducing fat while preserving muscle mass. In addition, WVE-007 produced sustained, dose-dependent suppression of serum target protein levels for at least seven months, supporting potential once- or twice-yearly dosing. Another company, Tangram Therapeutics, completed first patient dosing in the Phase 1/2 clinical trial of its lead candidate TGM-312 this quarter. TGM-312 is a GalNAc-siRNA therapy developed using Tangram’s proprietary RNAi chemistry platform GalOmic, designed to specifically silence a novel target gene in hepatocytes for the treatment of metabolic dysfunction-associated steatohepatitis (MASH). The drug may enable once-quarterly subcutaneous dosing, improving treatment convenience for patients. Multiple Large Pharmaceutical Companies Announce Billion-Dollar Oligonucleotide Partnerships In terms of industry collaboration, several major pharmaceutical companies entered large oligonucleotide-focused deals this quarter. In February, Roche subsidiary Genentech signed a global research collaboration and license agreement with SanegeneBio to jointly develop an RNAi therapy based on SanegeneBio’s proprietary RNAi drug discovery platform. Under the agreement, SanegeneBio will receive an upfront payment of $200 million and may earn development and commercial milestone payments totaling up to $1.5 billion. The company’s platform integrates novel chemical modification and delivery technologies, including the tissue-selective LEAD extrahepatic delivery technology, enabling the development of breakthrough RNAi drugs with potential best-in-class or first-in-class profiles across multiple disease areas. In the same month, Madrigal Pharmaceuticals signed a global exclusive licensing agreement worth up to $4.4 billion with RiboLife Science and its subsidiary Ribocure Pharmaceuticals. The companies will jointly develop six innovative siRNA therapies targeting MASH using RiboLife’s liver-targeted RiboGalSTAR platform. In addition, GSK and Frontier Biotechnologies entered a collaboration exceeding $1 billion. Under the agreement, GSK will obtain global exclusive rights to develop, manufacture, and commercialize two siRNA pipeline candidates, one of which has entered the Investigational New Drug (IND) stage while the other remains in preclinical development. Meanwhile, Eli Lilly and Company also reached an acquisition agreement with Orna Therapeutics valued at up to $2.4 billion. Orna is advancing a cell therapy platform based on engineered circular RNA combined with novel lipid nanoparticle technology, enabling patients to generate therapeutic immune cells in vivo to target the underlying mechanisms of disease. Orna’s lead program, ORN-252, is an in vivo CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy approaching clinical trials, intended for the treatment of B-cell-driven autoimmune diseases. Advancing Predictive Metabolism Research to Support siRNA Drug Development These developments show that many of the major transactions this quarter were centered around siRNA therapies. As siRNA therapeutics continue to advance rapidly, establishing reliable in vitro metabolic models has become essential for accurately predicting in vivo behavior and enabling efficient development decisions. Unlike traditional small molecules, oligonucleotides, particularly GalNAc-conjugated siRNAs, undergo complex nuclease-mediated metabolism that varies significantly across biological compartments, making conventional in vitro systems insufficient for translational prediction. To better meet clients’ need, WuXi AppTec DMPK team has developed a comprehensive framework for building and validating predictive in vitro metabolic models tailored specifically for oligonucleotide therapeutics, integrating mechanistic experimentation with translational pharmacokinetic insight.  As shown from a recent peer-reviewed study investigating the metabolism of a representative GalNAc-conjugated siRNA, WuXi AppTec scientists systematically evaluated multiple biological systems to determine which models most accurately replicate in vivo metabolism. The research demonstrated that carefully selected matrices, such as serum and heparin-anticoagulated plasma for blood metabolism, along with optimized liver homogenates, tritosomes, and plated hepatocytes for hepatic metabolism, can closely reproduce metabolite profiles observed in vivo, significantly improving in vitro–in vivo correlation (IVIVC) for oligonucleotide candidates . Importantly, the study also revealed how experimental conditions, including buffer composition and pH, influence nuclease activity and metabolic outcomes, underscoring the need for modality-specific model optimization rather than reliance on conventional assay formats.  Building upon these insights, WuXi AppTec DMPK platform incorporates a diverse panel of validated in vitro stability and metabolism systems, including plasma, tissue homogenates, subcellular fractions, and hepatocyte models, to characterize degradation pathways, metabolite formation, and compartment-specific disposition mechanisms. Cross-species evaluation strategies further support translational relevance by identifying metabolic differences between animal models and humans, helping reduce clinical uncertainty early in development.  Through the integration of mechanistic metabolism studies, advanced bioanalysis, and model validation workflows, WuXi AppTec DMPK enables developers to better predict oligonucleotide stability, optimize molecular design, and refine development strategies with greater confidence. These capabilities provide a robust scientific foundation for understanding oligonucleotide biotransformation and accelerate the progression of RNA-based therapeutics from discovery toward clinical application. 参考资料： [1] 各公司官网 免责声明：本文仅作信息交流之目的，文中观点不代表药明康德立场，亦不代表药明康德支持或反对文中观点。本文也不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。 版权说明：欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。转载授权请在「药明康德」微信公众号回复“转载”，获取转载须知。 分享，点赞，在看，聚焦全球生物医药健康创新

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放 截至04月08日15点59分，近期共有 370 本期刊发布了 691 篇文章，其中糖尿病相关的文章共 189 篇，覆盖 21 个领域的内容。中国专家参与发表的文章有 42 篇。今日，影响因子最高的文章刊登在 Nature reviews. Endocrinology (IF: 40.000) 期刊上。 今日头条 Headlines 01 PLoS medicine IF: 09.900 腹型肥胖患病率趋势对中国老年人群痴呆、心血管疾病、功能障碍及死亡率的影响：2020-2050年马尔可夫情景模拟 Zhou, Yujing, Zeng, Minrui, Chen, Yuntao, Bandosz, Piotr, Brunner, Eric, Liao, Jing, etc. 近日，一项研究通过马尔可夫情景模拟，分析了2020-2050年中国老年人群中腹型肥胖患病率趋势对痴呆、心血管疾病、功能障碍及死亡率的影响。研究指出，腹型肥胖作为可改变的共同危险因素，其患病率趋势将显著影响老年人群的疾病负担分布，为制定针对性公共卫生策略提供关键数据支持。 该研究使用2000-2015年中国健康与营养调查数据，模拟了三种腹型肥胖患病率趋势：持续增长、稳定（2015年水平）及增速减半（改善）。腹型肥胖定义为男性腰围≥90厘米、女性≥85厘米。研究针对≥65岁中国老年人，采用马尔可夫模型按性别和年份估算痴呆、心血管疾病、功能障碍及死亡率的发生情况。 在持续增长情景下，2050年相关疾病负担将显著上升：痴呆病例预计达3780万例（95%置信区间[3670万, 3890万]），功能障碍病例6810万例（[6670万, 6950万]），心血管疾病1.983亿例（[19650万, 20040万]），死亡1760万例（[1650万, 1870万]）。 与持续增长情景相比，最优和改善情景下痴呆与功能障碍负担反而增加。具体而言，最优情景下痴呆病例增加139.6万例（95%UI[589.1, 2293.9]），功能障碍增加257.06万例（[1081.0, 4024.9]）；改善情景下痴呆增加711.4万例（[589.1, 2293.9]），功能障碍增加1289.5万例（[569.5, 2034.2]）。研究认为，这一现象主要因心血管疾病死亡率降低导致风险人群寿命延长，从而扩大了痴呆和功能障碍的患病基数。 分析显示，≥80岁人群和女性受影响最为显著。心血管疾病方面，持续增长情景下2030年病例将减少，但2050年变化趋势尚不确定。 研究存在一定局限性：假设其他风险因素保持不变，且未纳入多重共病风险因素的建模分析，可能影响结果的全面性。 研究结论指出，腹型肥胖控制或可降低心血管疾病发病率和死亡率，但随着寿命延长，疾病负担将转向痴呆和功能障碍。因此，需制定综合的全生命周期公共卫生策略，以应对老年人群中痴呆及其共病的动态变化模式。 本文由 韩玉莲 编辑 扫描二维码查看源文 PLoS medicine | Ahead of Print. 10.1371/journal.pmed.1004970 02 Diabetes, obesity & metabolism IF: 05.700 替尔泊肽治疗2型糖尿病患者代谢异常的真实世界临床证据：多中心回顾性观察北海道-TZP研究 Maruyama, Fumika, Kitsunai, Hiroya, Kitao, Naoyuki, Wakabayashi, Yoshinori, Ito, Miki, Kurihara, Hiroyoshi, etc. 在线发表的多中心回顾性观察研究——北海道-TZP研究针对日本北海道地区10家医疗中心的828例2型糖尿病（T2D）患者展开分析，旨在验证替尔泊肽在真实世界临床实践中的疗效。该研究由Maruyama Fumika等多国作者联合完成，填补了此前3期临床试验仅在特定人群中开展的局限，为临床决策提供更广泛的真实世界证据支持。 研究方法显示，828例入组患者中，平均年龄为55.6±12.5岁，平均体重指数（BMI）30.6±5.8 kg/m2，提示患者群体普遍存在超重或肥胖特征。基线数据表明，81.3%的患者正在接受基于肠促胰素的药物治疗，反映了真实临床中T2D患者复杂的治疗背景。研究要求患者接受替尔泊肽治疗至少6个月，主要观察指标包括糖化血红蛋白（HbA1c）水平变化、体重变化以及因不良反应或其他临床原因导致替尔泊肽停药的情况。 在治疗效果方面，研究结果显示：替尔泊肽治疗6个月后，患者糖化血红蛋白（HbA1c）平均降低1.07%（95%置信区间[CI]-1.16~-0.98，P<0.001），体重平均减轻3.1kg（95%CI -3.4~-2.8，P<0.001）。值得注意的是，45例（占总样本5.4%）患者因不良反应、个人偏好或其他临床原因中断治疗，整体停药率低于临床预期。此外，无论患者在基线时是否接受过肠促胰素类药物治疗，替尔泊肽均能维持一致的疗效，表明其对不同治疗背景的T2D患者均适用。 研究结论指出，替尔泊肽在真实世界临床环境中对2型糖尿病患者的代谢异常（如高血糖、超重/肥胖）具有显著改善作用，且无论患者既往治疗方案如何，均能维持良好的疗效和安全性。这一发现为临床医生提供了新的治疗选择，尤其适用于合并多种治疗需求或对常规药物反应不佳的患者群体。 本文由 韩玉莲 编辑 扫描二维码查看源文 Diabetes, obesity & metabolism | Ahead of Print. 10.1111/dom.70734 03 Diabetes, obesity & metabolism IF: 05.700 1型糖尿病患者运动表现的预测因素：低血糖恐惧、血糖控制和血管健康的作用——一项回顾性横断面研究 Kooistra, Arne, van Kammen, Klaske, Bekker, Isabel, van Dijk, Peter R, Lutgers, Helen L, Dekker, Rienk, etc. 在荷兰格罗宁根大学医学中心开展的一项回顾性横断面研究中，研究人员分析了122名参与多学科康复项目的1型糖尿病成人患者，以探究运动表现降低的预测因素，重点关注低血糖恐惧、血糖控制（糖化血红蛋白HbA1c）及血管健康（微血管并发症）的作用。 1型糖尿病患者的心肺功能常受损，尽管生理决定因素已被研究，但心理障碍如低血糖恐惧等尚未得到充分探索。研究假设，糖化因素（包括HbA1c、糖尿病病程、微血管并发症）和低血糖恐惧会预测运动表现降低。 该研究为单中心回顾性分析，纳入标准为参与多学科康复项目的1型糖尿病成人。主要终点指标包括运动时的氧摄取（VO₂）、功率输出及不同通气阈值下的心率，涵盖第二通气阈值和峰值运动数据。预测变量包括年龄、性别、体重指数（BMI）、吸烟史、糖尿病病程、HbA1c、微血管并发症及低血糖恐惧量表评分，统计分析采用组间比较和逐步线性回归。 结果显示，122名参与者中位年龄33岁，76名为女性，中位HbA1c为75 mmol/mol（四分位距63-93）；106名参与者完成了低血糖恐惧调查，中位Worry评分为23.5，Behaviour评分为20.0。更高的HbA1c水平与第二通气阈值及峰值VO₂负相关（β=-0.085和β=-0.089），同时与功率输出和心率降低相关。更大的低血糖恐惧则预测第二通气阈值（β=-21.95）和峰值运动（β=-28.97）时的功率输出显著降低。微血管并发症与通气阈值处的心率降低相关，且多并发症患者的影响更强。 该研究结论表明，**低血糖恐惧**、**HbA1c**及**微血管并发症**是1型糖尿病患者运动表现降低的关键决定因素，提示需整合生理（如血糖控制）与心理（如低血糖恐惧干预）的综合干预措施。 本文由 韩玉莲 编辑 扫描二维码查看源文 Diabetes, obesity & metabolism | Ahead of Print. 10.1111/dom.70729 中国发表（42） China Scientific data IF: 06.900Ahead of Print.No.01Synthetic data Using Population Profiles for cardiOvascular Risk facTors (SUPPORT) in mainland China中国内地基于人群特征的心血管风险因素合成数据（SUPPORT）DOI: 10.1038/s41597-026-07192-5 Chung-Hua Yen K'o Tsa ChihVolume 62, Issue 4No.02[Retrospective study on the effects of femtosecond laser-assisted cataract surgery on the cornea in diabetic patients]飞秒激光辅助白内障手术对糖尿病患者角膜影响的回顾性研究DOI: 10.3760/cma.j.cn112142-20250805-00331 Biomaterials IF: 12.900Ahead of Print.No.03A single-component photocurable chitosan hydrogel mitigates inflammation and promotes angiogenesis and neurogenesis for diabetic wound healing单组分光固化壳聚糖水凝胶减轻炎症并促进血管生成和神经发生以实现糖尿病创面愈合DOI: 10.1016/j.biomaterials.2026.124161 J Psychosom Res IF: 03.300Ahead of Print.No.04Network comparative analysis of anxiety and depressive symptoms in patients with hypertension and diabetes comorbidity: A cross-sectional study高血压合并糖尿病患者焦虑和抑郁症状的网络比较分析：一项横断面研究DOI: 10.1016/j.jpsychores.2026.112649 ACS Appl Mater Interfaces IF: 08.200Ahead of Print.No.05ECN Coated with Met Can Inhibit PD-L1 Expression in Tumor Cells and Enhance Immune-Mediated Antitumor Effects in CT26 Cells包被二甲双胍的大肠杆菌Nissle 1917可抑制肿瘤细胞PD-L1表达并增强CT26细胞中免疫介导的抗肿瘤效果DOI: 10.1021/acsami.6c02414 International journal of obesity IF: 03.800Ahead of Print.No.06Risk factors and clinical nomogram for fatty pancreas in adults with obesity: a case-control study肥胖成人脂肪性胰腺的危险因素及临床列线图——一项病例对照研究DOI: 10.1038/s41366-026-02068-5 World J Mens Health IF: 04.100Ahead of Print.No.07Influence of Male Body Mass Index on Sperm Quality and In Vitro Fertilization Success Rates男性体重指数对精子质量和体外受精成功率的影响DOI: 10.5534/wjmh.250191 European journal of radiology IF: 03.300Ahead of Print.No.08Who benefits from a filter? Developing clinical prediction models for thrombus dislodgement in hospitalized patients with deep vein thrombosis: A multicenter retrospective study滤器谁受益？住院深静脉血栓患者血栓脱落的临床预测模型开发：一项多中心回顾性研究DOI: 10.1016/j.ejrad.2026.112816 Renal failure IF: 03.000Volume 48, Issue 1No.09Comparing the associations of eight surrogate markers of insulin resistance with rapid decline in kidney function and the incidence of CKD in Chinese middle-aged and elderly non-diabetic population比较八种胰岛素抵抗替代标志物与中国中老年非糖尿病人群肾功能快速下降及慢性肾脏病发生率的关联DOI: 10.1080/0886022X.2026.2633853 Zhonghua yixue zazhiVolume 106, Issue 13No.10[Correlation analysis of serum transforming growth factor-β stimulated clone 22 domain family member 4 with type 2 diabetes mellitus combined with metabolic associated fatty liver disease]血清转化生长因子-β刺激克隆22域家族成员4与2型糖尿病合并代谢相关脂肪肝的相关性分析DOI: 10.3760/cma.j.cn112137-20250827-02199 PloS one IF: 02.600Volume 21, Issue 4No.11Metformin attenuates TBHP-induced oxidative injury in human lens epithelial cells and is associated with SIRT1/FOXO1-related autophagy二甲双胍减轻叔丁基过氧化氢诱导的人晶状体上皮细胞氧化损伤并与SIRT1/FOXO1相关自噬有关DOI: 10.1371/journal.pone.0346822 PLoS medicine IF: 09.900Ahead of Print.No.12Impact of abdominal obesity prevalence trends on dementia, cardiovascular disease, functional impairment, and mortality in older Chinese adults: A Markov scenario simulation, 2020-2050腹型肥胖患病率趋势对中国老年人群痴呆、心血管疾病、功能障碍及死亡率的影响：2020-2050年马尔可夫情景模拟DOI: 10.1371/journal.pmed.1004970 Neuropeptides IF: 02.700Ahead of Print.No.13Microglial activation in diabetic neuropathic pain: Molecular trigger mechanisms, neuroimmune crosstalk, and emerging therapeutic targets糖尿病神经病理性疼痛中小胶质细胞激活：分子触发机制、神经免疫串扰及新兴治疗靶点DOI: 10.1016/j.npep.2026.102612 Journal of molecular medicine IF: 04.200Volume 104, Issue 1No.14Metformin sensitizes endometriosis to medroxyprogesterone acetate treatment through MIG-6 mediated signaling二甲双胍通过MIG-6介导的信号通路增强子宫内膜异位症对醋酸甲羟孕酮治疗的敏感性DOI: 10.1007/s00109-026-02655-z Aging Clin Exp Res IF: 03.400Ahead of Print.No.15Comparison of eight insulin resistance surrogate indices in predicting incident stroke among middle-aged and older individuals without diabetes: a nationwide prospective cohort study八种胰岛素抵抗替代指标在无糖尿病的中老年人群中预测卒中事件的全国性前瞻性队列研究比较DOI: 10.1007/s40520-026-03376-6 Apoptosis IF: 08.100Volume 31, Issue 4No.16SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic kidney diseaseSIRT1调节的线粒体自噬减轻糖尿病肾病中脂毒性诱导的铁死亡DOI: 10.1007/s10495-026-02267-5 Journal of diabetes research IF: 03.400Volume 2026, Issue 1No.17Screening Autophagy-Related DKD Biomarkers Based on Bulk RNA and Single-Cell Analysis and Uncovering Their Regulatory Mechanisms in DKD Renal Fibrosis基于批量RNA和单细胞分析筛选自噬相关DKD生物标志物并揭示其在DKD肾纤维化中的调控机制DOI: 10.1155/jdr/3768039 Food & function IF: 05.400Ahead of Print.No.18Structural activity remodeling of wheat protein peptides during simulated gastrointestinal digestion: insights into antioxidant and enzyme inhibitory functionalities小麦蛋白肽在模拟胃肠消化过程中的结构活性重塑及其抗氧化和酶抑制功能见解DOI: 10.1039/d5fo05244k J Diabetes Investig IF: 03.000Ahead of Print.No.19Factors associated with discrepancy between glycated hemoglobin and glucose management indicator糖化血红蛋白与血糖管理指标差异相关因素DOI: 10.1111/jdi.70306 Advanced science IF: 14.100Ahead of Print.No.20Lipoic Acid-Intervened Decellularized Stem Cell Spheroid-Based Injectable Granular Gel for Diabetic Tissue Regeneration硫辛酸干预的脱细胞干细胞球基可注射颗粒凝胶用于糖尿病组织再生DOI: 10.1002/advs.202521924 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.21Diabetes Mellitus and Early Antiplatelet Treatment for Minor Stroke Following Intravenous Thrombolysis: Prespecified Secondary Analysis of the EAST Trial糖尿病与静脉溶栓后小卒中的早期抗血小板治疗：EAST试验的预设次要分析DOI: 10.1111/dom.70745 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.22Differential Impact of Body Mass Index on Recurrence, Cardiac Remodelling, and Quality of Life After Atrial Fibrillation Ablation: Insights From the China-AF RegistryBMI对房颤消融术后复发、心脏重塑及生活质量的差异影响：中国房颤注册研究数据探究DOI: 10.1111/dom.70740 Clin Appl Thromb Hemost IF: 02.000Volume 32, Issue No.23Standard Modifiable Cardiovascular Risk Factors and Prognostic Outcomes in Non-Valvular Atrial Fibrillation Patients on Oral Anticoagulants可修正心血管危险因素与非瓣膜性心房颤动口服抗凝药物治疗患者的预后结局DOI: 10.1177/10760296261442055 Arh Hig Rada Toksikol IF: 01.600Volume 77, Issue 1No.24Forsythoside A attenuates metabolic dysfunction in type 2 diabetic mice by inhibiting the MAPK and activating the Nrf2 signalling pathways连翘酯苷A通过抑制MAPK和激活Nrf2信号通路改善2型糖尿病小鼠的代谢功能障碍DOI: 10.2478/aiht-2026-77-4026 Journal of endocrinology IF: 03.900Ahead of Print.No.25The Impact and Potential Mechanisms of Long Noncoding RNA ENST00000521141.1 on Human White Adipocyte Differentiation长链非编码RNA ENST00000521141.1对人白色脂肪细胞分化的影响及潜在机制DOI: 10.1530/JOE-25-0360 Pancreas IF: 01.700Ahead of Print.No.26The Effect of Different Lipid-lowering Methods on the Clinical Outcomes of Hyper-triglyceridemic Acute Pancreatitis不同降脂方法对高甘油三酯血症性急性胰腺炎临床结局的影响DOI: 10.1097/MPA.0000000000002639 Carbohydrate polymers IF: 12.500Volume 381, Issue No.27A self-healing, pH/glucose-responsive carboxymethyl chitosan and oxidized bacterial nanocellulose hydrogel for insulin and taurine delivery in diabetic wound healing用于糖尿病伤口愈合中胰岛素和牛磺酸递送的自修复pH/葡萄糖响应型羧甲基壳聚糖和氧化细菌纳米纤维素水凝胶DOI: 10.1016/j.carbpol.2026.125133 Carbohydrate polymers IF: 12.500Volume 381, Issue No.28A bio-nanocomposite hydrogel based on β-cyclodextrin and straw mushroom (Volvariella volvacea) soluble polysaccharide for the delivery of capsaicin and alleviation effect on type II diabetes mellitus一种基于β-环糊精和稻草菇（Volvariella volvacea）可溶性多糖的生物纳米复合水凝胶用于辣椒素递送及II型糖尿病缓解DOI: 10.1016/j.carbpol.2025.124857 Carbohydrate polymers IF: 12.500Volume 381, Issue No.29Advances in marine polysaccharides for the prevention and treatment of diabetes海洋多糖在糖尿病防治中的研究进展DOI: 10.1016/j.carbpol.2026.125189 Archivos espa?oles de urología IF: 00.600Volume 79, Issue 2No.30Effect of Cinacalcet Combined With Sevelamer Hydrochloride on the Incidence of Urolithiasis in Maintenance Hemodialysis Patients With Diabetic Kidney Disease西那卡塞联合盐酸司维拉姆对糖尿病肾病维持性血液透析患者尿石症发生率的影响DOI: 10.56434/j.arch.esp.urol.20267902.39 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.31Adherence to the EAT-Lancet Diet, Genetic Susceptibility and Risk of Obesity and Obesity-Related Morbidities: A Prospective Cohort Study坚持EAT-Lancet饮食、遗传易感性与肥胖及肥胖相关疾病风险：一项前瞻性队列研究DOI: 10.1111/dom.70732 J Agric Food Chem IF: 06.200Ahead of Print.No.32Combined Use of Tryptophan and Fu Brick Tea in Low Doses Promotes Weight Loss in Mice by Modulating AhR-Mediated Tryptophan Metabolism and Reshaping the Gut Microbiota低剂量色氨酸与茯砖茶联合使用通过调节AhR介导的色氨酸代谢和重塑肠道菌群促进小鼠体重减轻DOI: 10.1021/acs.jafc.6c00137 Pulmonolgy IF: 06.400Volume 32, Issue 1No.33Plasma proteomic signatures linking preserved ratio impaired spirometry to cardiometabolic diseases and multimorbidity: A longitudinal cohort study血浆蛋白质组学特征将保留比值型肺功能受损与心脏代谢疾病及共病联系起来：一项纵向队列研究DOI: 10.1080/25310429.2026.2650733 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.34Beyond Weight: Systems Biology and Precision Medicine Redefine Obesity as a Multidimensional Disease超越体重：系统生物学与精准医学将肥胖重新定义为多维疾病DOI: 10.1111/dom.70724 Archivos espa?oles de urología IF: 00.600Volume 79, Issue 2No.35Efficacy of Retrograde Intrarenal Surgery Combined with Super-Mini Percutaneous Nephrolithotomy versus that of Microchannel Percutaneous Nephrolithotomy in the Treatment of Complex Renal Stones逆行肾内手术联合超微经皮肾镜取石术与微通道经皮肾镜取石术治疗复杂性肾结石的有效性比较DOI: 10.56434/j.arch.esp.urol.20267902.33 Carbohydrate polymers IF: 12.500Volume 381, Issue No.36Retraction notice to "hUC-MSCs lyophilized powder loaded polysaccharide ulvan driven functional hydrogel for chronic diabetic wound healing" [Carbohydrate Polymers 288 (2022) 119404]关于“负载多糖褐藻糖胶的人脐带间充质干细胞冻干粉末驱动功能性水凝胶用于慢性糖尿病伤口愈合”的撤回通知DOI: 10.1016/j.carbpol.2026.125208 Journal of diabetes IF: 03.700Volume 18, Issue 4No.37Association Between Socioeconomic Status and the Prevalence of Metabolic Diseases: A Nationwide Cross-Sectional Study in China社会经济地位与代谢性疾病患病率的关联：中国全国性横断面研究DOI: 10.1111/1753-0407.70222 Carbohydrate polymers IF: 12.500Volume 381, Issue No.38Structural characterization and hypoglycemic activity of a novel pectic polysaccharide extracted from Atractylodes lancea rhizome白术根茎中新型果胶多糖的结构表征及其降血糖活性DOI: 10.1016/j.carbpol.2026.125096 Int J Biol Sci IF: 10.000Volume 22, Issue 6No.39Role of Copper Homeostasis and Cuproptosis in Cardiovascular Disease: Molecular Insights and Metabolic Perspectives铜稳态与铜凋亡在心血管疾病中的综合综述DOI: 10.7150/ijbs.126580 Br J Clin Pharmacol IF: 03.000Ahead of Print.No.40Integrating generative AI and genetic causal inference identifies metformin as a repurposing candidate for normal tension glaucoma整合生成式AI与遗传因果推断识别二甲双胍作为正常眼压性青光眼的再利用候选药物DOI: 10.1002/bcp.70537 Carbohydrate polymers IF: 12.500Volume 381, Issue No.41A spatiotemporally programmed, matrix metalloproteinase-9-responsive hyaluronic acid/polyglutamate hydrogel for accelerating chronic diabetic wound healing一种时空程序设计的、基质金属蛋白酶-9响应性透明质酸/聚谷氨酸水凝胶用于加速慢性糖尿病伤口愈合DOI: 10.1016/j.carbpol.2026.125211 Internal medicine journal IF: 01.500Ahead of Print.No.42Semaglutide for Aboriginal and Torres Strait Islander cardiovascular care: equity, cost and real-world hurdles司美格鲁肽用于原住民和托雷斯海峡岛民的心血管护理：公平性、成本及现实障碍DOI: 10.1111/imj.70387 其他发布内容（145） More Published Articles BMC infectious diseases IF: 03.000Ahead of Print.No.01UNAIDS 95-95-95 targets in older people living with HIV in urban and rural KwaZulu-Natal, South Africa南非夸祖鲁-纳塔尔省城乡地区老年HIV感染者的UNAIDS 95-95-95目标DOI: 10.1186/s12879-026-13273-y Nature reviews. Endocrinology IF: 40.000Ahead of Print.No.02Data-driven diabetes mellitus subtypes and precision care数据驱动的糖尿病亚型与精准护理DOI: 10.1038/s41574-026-01251-y Scientific reports IF: 03.900Ahead of Print.No.03Effects of aminoglycosides on macrophage viability and antimicrobial function under high-glucose exposure氨基糖苷类抗生素在高糖暴露下对巨噬细胞活力及抗菌功能的影响DOI: 10.1038/s41598-026-46905-z Molecular psychiatry IF: 10.100Ahead of Print.No.04Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank在创伤后应激障碍中可扩展的生物标志物发现：整合来自医疗系统生物样本库的基因组和表型证据DOI: 10.1038/s41380-026-03553-z Cell death and disease IF: 09.600Ahead of Print.No.05Growth hormone-releasing hormone attenuates amyloid deposition and neuroinflammation in Alzheimer's disease models生长激素释放激素减弱阿尔茨海默病模型中的淀粉样蛋白沉积和神经炎症DOI: 10.1038/s41419-026-08699-w Nutrition & diabetes IF: 05.200Ahead of Print.No.06Diabetes, hyperglycemia, and brain MRI biomarkers: results from SOL-INCA MRI study糖尿病、高血糖与脑MRI生物标志物：SOL-INCA MRI研究结果DOI: 10.1038/s41387-026-00415-z British journal of ophthalmology IF: 03.500Ahead of Print.No.07Nomogram for predicting implant exposure risk following enucleation or evisceration with vicryl-meshed hydroxyapatite implants用于预测眼球摘除或眼球内容剜出术后薇乔网羟基磷灰石植入物暴露风险的列线图DOI: 10.1136/bjo-2025-328883 BMJ Sexual & Reproductive Health IF: 02.800Ahead of Print.No.08Purchase of hormonal contraceptive methods after delivery: a population-based study from Finland产后激素避孕方法的购买：来自芬兰的基于人群的研究DOI: 10.1136/bmjsrh-2025-203105 American journal of perinatology IF: 01.200Ahead of Print.No.09Social Determinants of Health, Perceived Stress Scores, and Adverse Pregnancy Outcomes健康的社会决定因素、感知压力评分与不良妊娠结局DOI: 10.1055/a-2848-3471 Fitoterapia IF: 02.600Ahead of Print.No.10Modulation of oxidative biomarkers and carbohydrate metabolic enzyme activity byHypsizygusulmariuspolysaccharide in Streptozotocin/nicotinamide-induced diabeticratsHypsizygusulmarius多糖对链脲佐菌素/烟酰胺诱导糖尿病大鼠氧化生物标志物及碳水化合物代谢酶活性的调节作用DOI: 10.1016/j.fitote.2026.107233 Endocrinol Diabetes Metab Case Rep IF: 00.700Volume 2026, Issue 2No.11Drug cross-reactivity between methimazole and propylthiouracil causing recurrent pancreatitis in thyroid storm甲巯咪唑与丙硫氧嘧啶的药物交叉反应导致甲状腺危象中的复发性胰腺炎DOI: 10.1530/EDM-25-0135 Cell metabolism IF: 30.900Ahead of Print.No.12How to train your rodent: Recommendations for the preclinical study of exercise-induced benefits in metabolic research如何训练你的啮齿动物：代谢研究中运动诱导益处的临床前研究建议DOI: 10.1016/j.cmet.2026.03.005 Biochim Biophys Acta Mol Basis Dis IF: 04.200Ahead of Print.No.13Domain-specific mechanisms of YAP1 variants in ocular coloboma revealed by in-vitro and organoid studies通过体外和类器官研究揭示YAP1变异在眼缺损中的特异性机制DOI: 10.1016/j.bbadis.2026.168231 Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.14Letter to the editor: "Prediction of retinopathy risk: A prospective cohort study in China"致编辑信：中国视网膜病变风险预测：一项前瞻性队列研究DOI: 10.1016/j.dsx.2026.103415 Burns IF: 02.900Ahead of Print.No.15What does "PICS" mean in major burns? Persistent critical illness or post-intensive care syndrome重度烧伤中“PICS”意味着什么？持续危重症还是重症监护后综合征DOI: 10.1016/j.burns.2026.107991 Scientific reports IF: 03.900Volume 16, Issue 1No.16Correction: Clinical implications of systolic blood pressure for diabetic retinopathy across HbA1c levels in a Japanese population更正：日本人群中糖化血红蛋白水平下收缩压对糖尿病视网膜病变的临床意义DOI: 10.1038/s41598-026-47168-4 Nature communications IF: 15.700Ahead of Print.No.17FRZB-induced anti-angiogenic effect via Caveolin-1-mediated TGFβ signallingFRZB诱导的抗血管生成作用通过Caveolin-1介导的TGFβ信号传导DOI: 10.1038/s41467-026-71326-x World J Mens Health IF: 04.100Ahead of Print.No.18A Novel Glycyrrhiza korshinskyi Cultivar 'Wongam' Alleviates Benign Prostatic Hyperplasia via G1/S Checkpoint Arrest and Apoptosis: Insights from Network Pharmacology and Experimental Validation新品种甘草‘Wongam’通过G1/S期检查点阻滞和凋亡缓解良性前列腺增生——基于网络药理学和实验验证的研究DOI: 10.5534/wjmh.250315 BMC musculoskeletal disorders IF: 02.400Ahead of Print.No.19Impact of high-intensity interval training vs. moderate-intensity continuous training combined with strength training on physical and metabolic outcomes in post-bariatric surgery patients with sarcopenic obesity高强度间歇训练与结合力量训练的中等强度持续训练对减重手术后肌少症肥胖患者身体和代谢结果的影响DOI: 10.1186/s12891-026-09722-z J Clin Sleep Med IF: 02.900Volume 22, Issue 1No.20Subjective and objective measures of sleep-related function from the Cardiovascular Endpoints For Obstructive Sleep Apnea with Twelfth Cranial Nerve Stimulation (CARDIOSA-12) trial : Sleep-related functional outcomes in CARDIOSA-12CARDIOSA-12试验中阻塞性睡眠呼吸暂停患者舌下神经刺激对睡眠相关功能的主客观测量：CARDIOSA-12试验中的睡眠相关功能结局DOI: 10.1007/s44470-026-00067-x J Clin Sleep Med IF: 02.900Volume 22, Issue 1No.21The role of parenting in associations of weight status with sleep duration and timing for children with mild sleep-disordered breathing抚养方式在轻度睡眠呼吸障碍儿童体重状态与睡眠时长及时机关联中的作用DOI: 10.1007/s44470-026-00066-y Nature communications IF: 15.700Ahead of Print.No.22Daily steps offset risks of sedentary behavior in the All of Us research programAll of Us研究项目中每日步数可抵消久坐行为的风险DOI: 10.1038/s41467-026-71652-0 International wound journal IF: 02.500Volume 23, Issue 4No.23Body Mass Index: A Key Factor in Surgical Site Infections After Kidney Transplantation?体重指数：肾移植术后手术部位感染的关键因素？DOI: 10.1111/iwj.70901 BMJ open IF: 02.300Volume 16, Issue 4No.24Early-life infectious and nutritional exposures and cardiovascular risk in early adulthood in Uganda: protocol for a new round of data collection in the Entebbe Mother and Baby Study birth cohort at 21 years (EMaBS@21)乌干达成年早期早年感染和营养暴露与心血管风险：Entebbe母婴研究出生队列21岁时新一轮数据收集方案（EMaBS@21）DOI: 10.1136/bmjopen-2026-119342 BMJ Global Health IF: 06.100Volume 11, Issue 4No.25Transition of obesity in India, 2006-2021: a state-wise investigation from an equity perspective印度2006-2021年肥胖的转变：从公平视角的邦级调查DOI: 10.1136/bmjgh-2025-021325 Autoimmunity reviews IF: 08.300Ahead of Print.No.26Predicting the course: Real-world trajectories toward minimal disease activity in psoriatic arthritis预测病程：银屑病关节炎患者达到最低疾病活动度的真实世界轨迹DOI: 10.1016/j.autrev.2026.104055 Am J Hum Genet IF: 08.100Ahead of Print.No.27Neurodevelopmental copy-number variants increase risk of internalizing and cardiometabolic multimorbidity: Findings from the UK Biobank神经发育拷贝数变异增加内化和心血管代谢共病风险：来自英国生物样本库的研究结果DOI: 10.1016/j.ajhg.2026.02.021 Med IF: 11.800Ahead of Print.No.28Comparative efficacy of phase 2-3 therapies for non-cirrhotic metabolic dysfunction-associated steatohepatitis: An updated network meta-analysis非肝硬化代谢功能障碍相关脂肪性肝炎2-3期疗法的比较有效性：一项更新的网络荟萃分析DOI: 10.1016/j.medj.2026.101077 BMJ case reports IF: 00.500Volume 19, Issue 4No.29Ectopic ACTH-dependent Cushing syndrome due to mature ovarian teratoma成熟卵巢畸胎瘤导致的异位ACTH依赖性库欣综合征DOI: 10.1136/bcr-2025-271716 Journal of perinatology : IF: 02.400Ahead of Print.No.30Trends in gabapentin use in a single-center neonatal intensive care unit from 2016-20242016-2024年单中心新生儿重症监护室中加巴喷丁使用趋势DOI: 10.1038/s41372-026-02673-2 BMC endocrine disorders IF: 03.300Ahead of Print.No.31Elevated gamma glutamyl transferase levels as screening marker of stage 3-4 hepatic fibrosis in youth-onset type 2 diabetes mellitus: a retrospective chart review青年发病2型糖尿病中γ-谷氨酰转移酶水平升高作为3-4期肝纤维化的筛查标志物：一项回顾性图表审查DOI: 10.1186/s12902-026-02255-5 Scientific reports IF: 03.900Ahead of Print.No.32Early intervention with tirzepatide or semaglutide influences anti-atherosclerotic effects in ApoE knockout mice替尔泊肽或司美格鲁肽的早期干预对ApoE基因敲除小鼠的抗动脉粥样硬化作用DOI: 10.1038/s41598-026-42437-8 Endocrinol Diabetes Metab Case Rep IF: 00.700Volume 2026, Issue 2No.33A silent aggressor: disseminated histoplasmosis with laryngeal and adrenal involvement in a diabetic patient沉默的侵略者：一名糖尿病患者中播散性组织胞浆菌病伴喉和肾上腺受累DOI: 10.1530/EDM-25-0137 BMC primary care IF: 02.600Ahead of Print.No.34Implementation project protocols to address obesity and hypertension in primary care practices in a large, integrated health system大型综合医疗系统初级保健实践中解决肥胖和高血压的实施项目方案DOI: 10.1186/s12875-026-03245-1 Toxicology IF: 04.600Ahead of Print.No.35Endocrine and Metabolism Modulating Effects of Paracetamol: From In Vitro Signaling to In Vivo Metabolic Reprogramming in Male Mice对乙酰氨基酚的内分泌和代谢调节作用：从体外信号传导到雄性小鼠体内代谢重编程DOI: 10.1016/j.tox.2026.154468 Asian Pac J Cancer PrevVolume 27, Issue 4No.36Scoring System for Predicting Breast Cancer Risk Among Women in Regions with Limited Healthcare Infrastructure in Indonesia印度尼西亚医疗基础设施有限地区女性乳腺癌风险预测评分系统DOI: 10.31557/APJCP.2026.27.4.1459 Asian Pac J Cancer PrevVolume 27, Issue 4No.37Thyroid Cancer and Precancerous Morbidity After Nuclear Fallout: Long-Term Cohort Study Near the Semipalatinsk Test Site核辐射落尘后的甲状腺癌及癌前病变：塞米巴拉金斯克试验场附近长期队列研究DOI: 10.31557/APJCP.2026.27.4.1469 Arch Endocrinol Metab IF: 02.300Volume 70, Issue 3No.38Individualized aerobic session modulates key metabolic genes in liver and muscle of male offspring from obese dams个性化有氧训练调节肥胖母鼠雄性后代肝脏和肌肉中的关键代谢基因DOI: 10.20945/2359-4292-2026-0030 Food & function IF: 05.400Ahead of Print.No.39Potential antiobesity and antihepatic steatosis effects of a Capsosiphon fulvescens (maesaengi) ethanol extract: in vitro and in vivo studies囊藻（maesaengi）乙醇提取物的潜在抗肥胖和抗肝脂肪变性作用：体外和体内研究DOI: 10.1039/d5fo05258k Am J Physiol Heart Circ Physiol IF: 04.100Volume 330, Issue 4No.40Elevated asprosin in postmenopause is associated with vasculometabolic complications绝经后升高的Asprosin与血管代谢并发症相关DOI: 10.1152/ajpheart.00042.2026 Kidney360 IF: 03.000Ahead of Print.No.41Molecular Characterization of the Effect of Glucagon-Like Peptide-1 Receptor Agonist Semaglutide in the Nephrotoxic Serum Nephritis Mouse Model胰高血糖素样肽-1受体激动剂司美格鲁肽在肾毒性血清性肾炎小鼠模型中的作用分子表征DOI: 10.34067/KID.0000001067 Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.42Authors' Reply: Addressing Disparity Efficacy of Finerenone-Empagliflozin Combination in Asian Patients with Diabetic Kidney Disease作者回复：解决非奈利酮-恩格列净联合用药在亚洲糖尿病肾病患者中的差异有效性DOI: 10.2215/CJN.0000001021 Asian Pac J Cancer PrevVolume 27, Issue 4No.43Association of Green Tea Consumption and the Risk of Liver Cancer Incidence among Japanese Adults日本成年人绿茶饮用与肝癌发病风险的关联DOI: 10.31557/APJCP.2026.27.4.1313 Cardiology in Review IF: 02.300Ahead of Print.No.44Prevalence and Factors Associated With Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction: A Meta-Analysis and Meta-Regression射血分数保留的心力衰竭中肺动脉高压的患病率及相关因素：一项荟萃分析和元回归分析DOI: 10.1097/CRD.0000000000001235 Clinical laboratory IF: 00.600Volume 72, Issue 3No.45Serum Direct Bilirubin and Hemoglobin A1c Predict Cognitive Impairment After Diabetes Mellitus Combined with Cerebral Infarction血清直接胆红素和糖化血红蛋白预测糖尿病合并脑梗死患者的认知障碍DOI: 10.7754/Clin.Lab.2024.240809 Plast Reconstr Surg IF: 03.400Ahead of Print.No.46Beyond Weight Loss: Association Between Glucagon-like peptide-1 Receptor Agonist Therapy and Incidence of Facial and Oculoplastic Procedures超越减肥：胰高血糖素样肽-1受体激动剂治疗与面部及眼整形手术发生率的关联DOI: 10.1097/PRS.0000000000013108 Arch Endocrinol Metab IF: 02.300Volume 70, Issue 3No.47Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?血清MOTS-c水平及MOTS-c m.1382A>C多态性与多囊卵巢综合征相关吗DOI: 10.20945/2359-4292-2026-0031 Arch Endocrinol Metab IF: 02.300Volume 70, Issue 3No.48Tirzepatide-induced ketoacidosis with hyperglycemia in a patient without diabetes替尔泊肽诱导的无糖尿病患者高血糖酮症酸中毒DOI: 10.20945/2359-4292-2026-0028 PloS one IF: 02.600Volume 21, Issue 4No.49FAVABEAN and FALAPhyl: Open-source pipelines for scalable 16s rRNA microbiome data processing and visualizationFAVABEAN和FALAPhyl：用于可扩展16S rRNA微生物组数据处理和可视化的开源管道DOI: 10.1371/journal.pone.0331145 Pharmacology IF: 03.200Ahead of Print.No.50Efficacy and Safety of Avacopan in ANCA-Associated Vasculitis: A Meta-Analysis of Randomized Controlled TrialsAvacopan在ANCA相关血管炎中的有效性和安全性：一项随机对照试验的荟萃分析DOI: 10.1159/000551892 Journal of medicinal chemistry IF: 06.800Ahead of Print.No.51Development of Structurally Simplified, Non-azadecalin Glucocorticoid Antagonists which Demonstrate In Vivo Activity结构简化的非氮杂十氢化萘类糖皮质激素拮抗剂的开发及其体内活性验证DOI: 10.1021/acs.jmedchem.5c03567 J Minim Access Surg IF: 01.100Ahead of Print.No.52Vesicocutaneous fistula following laparoscopic transabdominal pre-peritoneal inguinal hernia repair: An unusual complication - A case report腹腔镜经腹腹膜前腹股沟疝修补术后的膀胱皮肤瘘：一种罕见并发症——病例报告DOI: 10.4103/jmas.jmas_354_25 JCI insight IF: 06.100Ahead of Print.No.53Increased transvascular retention of atherogenic lipoproteins in type 2 diabetes relates to their enhanced proteoglycan-binding2型糖尿病中致动脉粥样硬化脂蛋白的血管外渗滞留增加与其增强的蛋白聚糖结合相关DOI: 10.1172/jci.insight.177849 Anesthesiology IF: 09.100Ahead of Print.No.54Gabapentin and Opioid Prescribing Trends among Adolescents Undergoing Common Procedures: A National Retrospective Cohort Study青少年常见手术围手术期加巴喷丁与阿片类药物处方趋势：一项全国回顾性队列研究DOI: 10.1097/ALN.0000000000006079 J Labelled Comp Radiopharm IF: 00.900Volume 69, Issue 4-6No.55Synthesis of Carbon-13 and Carbon-14 Labeled BI 690517 (Vicadrostat) and Its O-Glucuronide Metabolite BI 689875碳-13和碳-14标记的BI 690517（Vicadrostat）及其O-葡萄糖醛酸代谢物BI 689875的合成DOI: 10.1002/jlcr.70026 Bull Exp Biol Med IF: 00.600Ahead of Print.No.56Expression of IL-1β in the Left-Ventricular Myocardium of Rats with Insulin-Dependent Diabetes Mellitus and Its Combination with Arterial Hypertension胰岛素依赖型糖尿病及合并动脉高血压大鼠左心室心肌中IL-1β的表达DOI: 10.1007/s10517-026-06623-y Bull Exp Biol Med IF: 00.600Ahead of Print.No.57Erythrocyte Integrity, Thymocyte Volume Regulation, and Functional State of the Heart during Ischemia/Reperfusion in Rats with Type 2 Diabetes Mellitus2型糖尿病大鼠缺血/再灌注期间红细胞完整性、胸腺细胞体积调节及心脏功能状态DOI: 10.1007/s10517-026-06626-9 Metab Syndr Relat Disord IF: 01.700Volume 24, Issue 3No.58Semaglutide-Induced Weight Loss Is the Main Determinant for the Improvement of Hepatic Biochemistry and Elastographic Repeated Measurements with FibroScan® in Patients with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease司美格鲁肽诱导的体重下降是2型糖尿病合并代谢功能障碍相关脂肪性肝病患者肝脏生化指标及弹性成像重复测量改善的主要决定因素DOI: 10.1177/15578518251409025 Diabetes IF: 07.500Ahead of Print.No.59Human iPSC-Based Modeling Identifies Epigenetic Regulation at the KCNQ1 Locus During Early Islet Development That Contributes to Lower β-Cell Mass基于人类诱导多能干细胞的建模确定KCNQ1基因座在早期胰岛发育中的表观遗传调控导致β细胞质量降低DOI: 10.2337/db25-0721 Ther Innov Regul Sci IF: 01.900Ahead of Print.No.60The Future of Biologics: Lessons from Hatch-Waxman生物药的未来：哈奇-瓦克斯曼法案的启示DOI: 10.1007/s43441-026-00961-9 Clin Exp Nephrol IF: 01.700Ahead of Print.No.61Epidemiological analysis of kidney involvement in systemic lupus erythematosus using the national database of designated intractable diseases of Japan: a cross-sectional study of renewal applicants日本指定难病数据库中系统性红斑狼疮肾脏受累的流行病学分析：续约申请者的横断面研究DOI: 10.1007/s10157-026-02863-4 CEN case reports IF: 01.000Volume 15, Issue 3No.62CART for ascites accumulation and dialysis difficulty after hepatic cyst fenestration and bilateral nephrectomy in ADPKD: a case report常染色体显性多囊肾病（ADPKD）患者肝囊肿开窗术及双侧肾切除术后腹水蓄积与透析困难的无细胞浓缩腹水回输治疗（CART）：一例报告DOI: 10.1007/s13730-026-01113-6 Bull Exp Biol Med IF: 00.600Ahead of Print.No.63Pharmacological Effects of Humic Substances and the Signaling Mechanisms of Their Implementation腐殖质的药理作用及其实施的信号机制DOI: 10.1007/s10517-026-06621-0 AgingAhead of Print.No.64Toward actionable interventions in human aging (12th ARDD meeting, 2025)迈向人类衰老的可实施干预措施（第12届ARDD会议，2025年）DOI: 10.18632/aging.206368 Molecules IF: 04.600Volume 31, Issue 7No.65RETRACTED: Nazir et al. Curative Effect of Catechin Isolated from Elaeagnus Umbellata Thunb. Berries for Diabetes and Related Complications in Streptozotocin-Induced Diabetic Rats Model. Molecules 2021, 26, 137沙枣浆果中分离出的儿茶素对链脲佐菌素诱导的糖尿病大鼠模型糖尿病及相关并发症的疗效DOI: 10.3390/molecules31071183 Food & function IF: 05.400Ahead of Print.No.66Evaluation of the underutilized Malpighia glabra L. fruits as a future functional food: nutritional composition, phenolic profile, biological activities, and synergistic effects with pharmaceutical drugs未充分利用的巴巴多斯樱桃果实作为未来功能性食品的评估：营养成分、酚类物质谱、生物活性及与药物的协同效应DOI: 10.1039/d5fo03782d Neurosurgery IF: 03.900Ahead of Print.No.67Associations Between Transsphenoidal Surgery and Neuropsychiatric Disorders for Patients With Cushing's Disease经蝶手术与库欣病患者神经精神疾病的关联DOI: 10.1227/neu.0000000000004022 Anesthesiology IF: 09.100Ahead of Print.No.68Prevalence and Risk Factors of Deep Spinal Infection after Single-Shot Epidural Injections: A Nationwide Cohort Study of 3.8 Million Pain Outpatients单次硬膜外注射后深脊柱感染的患病率和危险因素：380万疼痛门诊患者的全国队列研究DOI: 10.1097/ALN.0000000000006081 Chronic illness IF: 01.800Ahead of Print.No.69Chores and diabetes self-management in youth: Initial findings from a cross-sectional study青少年家务劳动与糖尿病自我管理：一项横断面研究的初步发现DOI: 10.1177/17423953261436466 Chronic illness IF: 01.800Ahead of Print.No.70A new chapter in diabetes education: Qualitative reflections on type 5 diabetes recognition and response糖尿病教育的新篇章：关于5型糖尿病识别与应对的质性反思DOI: 10.1177/17423953261436468 Pharmacoepidemiol Drug Saf IF: 02.400Volume 35, Issue 4No.71Pharmacotherapeutic Monitoring and Drug-Related Problems in a Group of Patients From Colombia: Cross-Sectional Study, 2023-2024哥伦比亚一组患者的药物治疗监测与药物相关问题：2023-2024年横断面研究DOI: 10.1002/pds.70366 Work IF: 01.500Ahead of Print.No.72Knowledge, attitude, and practice of allied healthcare professionals about lifestyle medicine for diabetes: A cross-sectional study相关医疗专业人员对糖尿病生活方式医学的认知、态度和实践：一项横断面研究DOI: 10.1177/10519815261435992 Tropical doctor IF: 00.600Ahead of Print.No.73A case of melioidosis in Mexico: An unknown disease墨西哥一例类鼻疽病例：一种未知疾病DOI: 10.1177/00494755261439430 Journal of materials chemistry IF: 05.700Ahead of Print.No.74Blue light-activated berberine-gentamicin combination breaks down biofilms in diabetic foot ulcers蓝光激活小檗碱-庆大霉素联合可分解糖尿病足溃疡中的生物膜DOI: 10.1039/d6tb00081a Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.75Impact of Real Time, Flash and Retrospective Continuous Glucose Monitoring on Feto-Maternal Outcomes in Women With Gestational Diabetes and Pre-Gestational Diabetes: A Systematic Review and Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials实时、闪光和回顾性持续葡萄糖监测对患有妊娠糖尿病和孕前糖尿病女性的胎儿-母亲结局的影响：一项对随机对照试验进行试验序贯分析的系统综述和荟萃分析DOI: 10.1111/dom.70743 Primary care diabetes IF: 02.300Ahead of Print.No.76Long-term impact of continuous glucose monitoring on glycemic and metabolic control in type 1 diabetes: A three-year real-world evaluation持续葡萄糖监测对1型糖尿病血糖和代谢控制的长期影响：一项为期三年的真实世界评估DOI: 10.1016/j.pcd.2026.04.002 Bull Exp Biol Med IF: 00.600Ahead of Print.No.77Content of Atrial Natriuretic Peptide in Cardiomyocytes Granules of Newborn Female Rats with Type 1 Diabetes Mellitus1型糖尿病新生雌性大鼠心肌细胞颗粒中心房钠尿肽的含量DOI: 10.1007/s10517-026-06643-8 Retinal cases & brief reportsAhead of Print.No.78Macular Telangiectasia Type 2 With Bidirectional Neovascular Network黄斑毛细血管扩张症2型伴双向性新生血管网络DOI: 10.1097/ICB.0000000000001919 J Racial Ethn Health Disparities IF: 02.400Ahead of Print.No.79An Examination of African Immigrants With Overweight or Obesity: Weight, Lifestyle Behaviors, and Body Image Following Immigration对非洲移民超重或肥胖的考察：移民后的体重、生活方式行为及身体形象DOI: 10.1007/s40615-026-02954-8 Adv Clin Exp Med IF: 01.900Ahead of Print.No.80GPR149 (G protein-coupled receptor 149): Structure, signaling, and emerging roles in reproduction, metabolism, and neural functionGPR149（G蛋白偶联受体149）：结构、信号传导及在生殖、代谢和神经功能中的新兴作用DOI: 10.17219/acem/218248 Current obesity reports IF: 11.000Volume 15, Issue 1No.81Rethinking Obesity Prevention: A Call for Strategic and Operational Clarity重新思考肥胖预防：呼吁战略和操作层面的明确性DOI: 10.1007/s13679-026-00708-5 Obes Res Clin Pract IF: 02.300Ahead of Print.No.82Preoperative serum zinc status in morbid obesity patients scheduled for bariatric surgery: A cross-sectional study拟接受减重手术的病态肥胖患者术前血清锌水平：一项横断面研究DOI: 10.1016/j.orcp.2026.03.006 Obesity surgery IF: 03.100Ahead of Print.No.83Effect of Metabolic Bariatric Surgery on Cardiovascular Outcomes in People with Obesity and Pre-existing Cardiovascular Disease: A Systematic Review and Meta-Analysis代谢减重手术对肥胖及既往心血管疾病患者心血管结局的影响：一项系统综述与荟萃分析DOI: 10.1007/s11695-026-08634-0 Obesity surgery IF: 03.100Ahead of Print.No.84Weight Trajectory in Young People Undergoing Sleeve Gastrectomy: Does Age Make a Difference? A Children's Obesity Surgery Multi-Institutional Collaborative (COSMIC) Analysis接受袖状胃切除术的年轻人的体重轨迹：年龄是否有影响？一项儿童肥胖手术多机构合作（COSMIC）分析DOI: 10.1007/s11695-026-08636-y Aesthetic plastic surgery IF: 02.800Ahead of Print.No.85Preoperative GLP-1 Receptor Agonists and Thromboinflammatory Markers in Patients Undergoing Abdominoplasty: A Prospective Monocentric Study术前GLP-1受体激动剂及血栓炎症标志物在接受腹壁成形术患者中的前瞻性单中心研究DOI: 10.1007/s00266-026-05805-3 Epidemiology IF: 04.400Ahead of Print.No.86An expedited chart review process for large database studies using natural language processing and multi-wave adaptive sampling使用自然语言处理和多波自适应抽样的大型数据库研究快速图表审查流程DOI: 10.1097/EDE.0000000000001978 A&A practice IF: 00.600Volume 20, Issue 4No.87Flow-Controlled Ventilation in Laparoscopic Surgery: A Case Series腹腔镜手术中的流量控制通气：一个病例系列DOI: 10.1213/XAA.0000000000002191 J Minim Access Surg IF: 01.100Ahead of Print.No.88Efficacy of Braun anastomosis after single-anastomosis sleeve jejunal bypass in prevention of bile reflux: A retrospective study单吻合口袖状空肠旁路术后布劳恩吻合术对胆汁反流的预防效果：一项回顾性研究DOI: 10.4103/jmas.jmas_280_25 J Minim Access Surg IF: 01.100Ahead of Print.No.89Skin stapler versus subcuticular suture for port-site skin closure in patients undergoing laparoscopic sleeve gastrectomy - A registry-based retrospective study over 4 years腹腔镜袖状胃切除术中端口部位皮肤闭合：皮肤缝合器与皮下缝合对比——一项基于注册的4年回顾性研究DOI: 10.4103/jmas.jmas_136_25 Eur J Clin Invest IF: 03.600Volume 56, Issue 4No.90The emerging problem of digital and self misuse of obesity management medications: Protecting their clinical value数字和自我滥用肥胖管理药物的新兴问题：保护其临床价值DOI: 10.1111/eci.70201 Pediatric pulmonology IF: 02.300Volume 61, Issue 4No.91Asthma in Children With Melanocortin 4 Receptor (MC4R) Gene Mutation Variant: A Case Series携带黑色素皮质素4受体(MC4R)基因突变变体的儿童哮喘：一项病例系列研究DOI: 10.1002/ppul.71611 Clinical nursing research IF: 01.800Ahead of Print.No.92Food Insecurity, Advanced Anthropometric Indices, and Central Obesity in Older Adults: Implications for Geriatric Nursing Assessments老年人食物不安全、高级人体测量指数与中心性肥胖：对老年护理评估的意义DOI: 10.1177/10547738261429356 Klin Mikrobiol Infekc LekVolume 31, Issue 4No.93[Assessing the nutritional status of treated HIV-positive individuals]接受治疗的HIV阳性个体的营养状况评估https://pubmed.ncbi.nlm.nih.gov/41944417 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.94Defining Obesity Under the Lancet Commission Criteria: Metabolic Syndrome-Anchored Body Fat Percentage Thresholds in Korean Adults基于《柳叶刀》委员会标准定义肥胖：韩国成年人以代谢综合征为锚点的体脂百分比阈值DOI: 10.1111/dom.70739 Metab Syndr Relat Disord IF: 01.700Ahead of Print.No.95Adiposity Measures Derived from Bioelectrical Impedance are Associated with Cardiometabolic Markers in Women with Polycystic Ovary Syndrome生物电阻抗法得出的肥胖测量指标与多囊卵巢综合征女性的心血管代谢指标相关DOI: 10.1177/15578518261437788 JAHA IF: 05.300Ahead of Print.No.96Characteristics of Protein Profiling and Biomarkers in Aortic Regurgitation With Heart Failure心力衰竭合并主动脉瓣反流患者中蛋白质谱及生物标志物的特征DOI: 10.1161/JAHA.125.047122 Hypertension IF: 08.200Ahead of Print.No.97Obstetric History Versus Biomarkers: Hypertension Risk Up to 15 Years Postpartum产科病史与生物标志物：产后15年高血压风险DOI: 10.1161/HYPERTENSIONAHA.125.25552 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.98Bigger Is Not Always Stronger: Citation Concentration and the Illusion of Journal Impact大不一定更强：引文集中度与期刊影响力的假象DOI: 10.1111/dom.70733 Dela J Public HealthVolume 12, Issue 1No.99Snapshot of Diabetes Risk, Risk Awareness, and Lifestyle Change Factors in Older Adults Attending Delaware Senior Centers特拉华州老年人中心参加者的糖尿病风险、生活方式行为及前驱糖尿病知识DOI: 10.32481/djph.2026.03.13 Oncoimmunology IF: 06.300Volume 15, Issue 1No.100Early local immune activation following intra-operative radiotherapy in human breast tissue术中放疗后人类乳腺组织的早期局部免疫激活DOI: 10.1080/2162402X.2026.2653318 J Korean Med Sci IF: 02.300Volume 41, Issue 12No.101The Impact of Vitamin D Deficiency and Osteoporosis on Benign Paroxysmal Positional Vertigo Recurrence: A Population-Based Study From the Korean National Health Insurance Service维生素D缺乏和骨质疏松症对良性阵发性位置性眩晕复发的影响：来自韩国国民健康保险服务的基于人群的研究DOI: 10.3346/jkms.2026.41.e99 Dela J Public HealthVolume 12, Issue 1No.102Recent Advances in Modeling and Prediction of Blood Glucose in Type 1 Diabetes1型糖尿病中的血糖预测与控制：机制、数据驱动及混合方法综合综述DOI: 10.32481/djph.2026.03.09 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.103Chronic Glycaemic Control Modulates the Relationship Between GIP and Glucagon Secretion Following Oral and Enteral Nutrients in Type 2 Diabetes慢性血糖控制调节2型糖尿病患者口服和肠内营养后GIP与胰高血糖素分泌的关系DOI: 10.1111/dom.70735 Diabetic medicine IF: 03.400Ahead of Print.No.104A consensus statement on a National Competency Framework for training and assessment of knowledge and skills in diabetes technologies, including hybrid closed loop (HCL), insulin pump systems, and continuous glucose monitoring (CGM) devices关于糖尿病技术（包括混合闭环（HCL）、胰岛素泵系统和连续葡萄糖监测（CGM）设备）知识和技能培训与评估的国家能力框架共识声明DOI: 10.1111/dme.70253 Int J Biol Sci IF: 10.000Volume 22, Issue 6No.105IGF2BP2 Deficiency in Macrophages Impairs Migration, Reprograms Metabolism, and Limits Tumor Progression巨噬细胞中IGF2BP2缺失损害迁移、重编程代谢并限制肿瘤进展DOI: 10.7150/ijbs.122142 Curēus IF: 01.300Volume 18, Issue 3No.106The Physiology, Pathophysiology, and Clinical Implications of Fluid Resuscitation in Critically Ill Patients重症患者液体复苏：当前指南、争议与临床应用DOI: 10.7759/cureus.104736 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.107Interrelationship Between Baseline HbA1c, SGLT-2 Inhibitor Use and Risk of Diabetic Ketoacidosis in Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis2型糖尿病成人患者基线糖化血红蛋白、SGLT-2抑制剂使用与糖尿病酮症酸中毒风险的相互关系：一项系统综述与荟萃分析DOI: 10.1111/dom.70728 Multiple sclerosis : IF: 05.000Ahead of Print.No.108Myelin oligodendrocyte glycoprotein antibody-associated disease and relapse risk: Effects of smoking and vascular risk factors髓鞘少突胶质细胞糖蛋白抗体相关疾病与复发风险：吸烟及血管危险因素的影响DOI: 10.1177/13524585261429292 Curēus IF: 01.300Volume 18, Issue 3No.109Post-colonoscopy Right Colon Perforation Misdiagnosed as Early Appendicitis: A Case Report结肠镜检查后右结肠穿孔误诊为早期阑尾炎：一例报告DOI: 10.7759/cureus.104779 Curēus IF: 01.300Volume 18, Issue 3No.110Hematemesis From Downhill Esophageal Varices Secondary to Superior Vena Cava Occlusion in a Patient With a Hemodialysis Catheter: A Case Report血液透析患者上腔静脉阻塞导致的下行性食管静脉曲张：一例报告DOI: 10.7759/cureus.104770 Child Neuropsychol IF: 01.900Ahead of Print.No.111The role of different components of executive function in the relationship between body mass index and dynamic balance in obese and normal children执行功能不同组成部分在肥胖与正常儿童体重指数和动态平衡关系中的作用DOI: 10.1080/09297049.2026.2648703 Circulation IF: 38.600Ahead of Print.No.112Multi-Organ Physiologic Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure with Preserved Ejection Fraction运动中的多器官生理缺陷识别射血分数保留的心力衰竭的临床和分子易感性DOI: 10.1161/CIRCULATIONAHA.125.077579 J Dev Orig Health Dis IF: 01.500Volume 17, Issue No.113Nativity differences in the body roundness index, with reference to body mass index, among Black adults in the United States: NHANES 2011-2018美国黑人成年人的出生地差异与身体圆润度指数（参照体重指数）：NHANES 2011-2018DOI: 10.1017/S204017442610052X Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.114Defining Acquired Hypothalamic Obesity: An Expert Call for Unified Diagnosis and Therapeutic Action定义后天性下丘脑肥胖：专家呼吁统一诊断与治疗行动DOI: 10.1111/dom.70725 Clinical endoscopy IF: 02.300Volume 59, Issue 2No.115Impact of glucagon-like peptide-1 receptor agonists on colonoscopy outcomes: a systematic review and meta-analysis胰高血糖素样肽-1受体激动剂对结肠镜检查结果的影响：一项系统综述和荟萃分析DOI: 10.5946/ce.2025.137 Annals of Transplantation IF: 01.400Volume 31, Issue No.116Prevalence of Obesity, Comorbidities, and Eligibility for Pre-Transplant Bariatric Surgery in 275 Patients Awaiting Kidney Transplant at a Single Center in Germany德国一家中心275名等待肾移植患者的肥胖、合并症及移植前减重手术资格患病率DOI: 10.12659/AOT.951621 Journal of orthopaedic surgery IF: 01.600Volume 34, Issue 1No.117Nerve block modality selection in total knee arthroplasty: Evaluating single-shot versus continuous catheter on postoperative patients' experience全膝关节置换术中神经阻滞方式选择：评估单次注射与持续导管对术后患者体验的影响DOI: 10.1177/10225536261440447 Endocr Metab Immune Disord Drug Targets IF: 02.000Ahead of Print.No.118Efficacy of Once-weekly Somatrogon in Children with Growth Hormone Deficiency After Switching from Daily Therapy每周一次Somatrogon在儿童生长激素缺乏症患者从每日治疗转换后的有效性DOI: 10.2174/0118715303452569260114103416 Population health management IF: 02.100Ahead of Print.No.119Chronic Care Management and Mortality Among Diabetic Patients with Multiple Chronic Conditions慢性病管理与合并多种慢性病的糖尿病患者死亡率DOI: 10.1177/19427891261437477 Circulation IF: 38.600Ahead of Print.No.120Mir147 Limits the Contribution of Non-Foamy Macrophages to AtherosclerosismiR-147限制非泡沫巨噬细胞对动脉粥样硬化的作用DOI: 10.1161/CIRCULATIONAHA.125.077821 Neurourology and urodynamics IF: 01.900Volume 45, Issue 4No.121The LURN Study-What Have We "LURN"ed So Far?LURN研究——我们至今学到了什么？DOI: 10.1002/nau.70224 Hypertension IF: 08.200Ahead of Print.No.122Blood Pressure Control and Mortality Among US Veterans美国退伍军人的血压控制与死亡率DOI: 10.1161/HYPERTENSIONAHA.125.25787 PeerJ IF: 02.400Volume 14, Issue No.123Comparison of primers for the pathogenicity factors vvhA and rpoS in Vibrio vulnificus environmental isolates from the Texas Coastal Bend region of the Gulf of Mexico墨西哥湾西部德克萨斯州海岸带地区创伤弧菌菌株的基因组分析及其对PCR检测的意义DOI: 10.7717/peerj.21027 JBMR plus IF: 02.400Volume 10, Issue 5No.124The therapeutic window: timing dentoalveolar surgery to minimize MRONJ risk in denosumab-treated osteoporotic patients骨质疏松症患者接受地舒单抗治疗时牙牙槽干预的时机对颌骨药物相关骨坏死（MRONJ）的影响DOI: 10.1093/jbmrpl/ziag038 Curēus IF: 01.300Volume 18, Issue 3No.125Clinically Symptomatic Vitamin E-Associated Peripheral Neuropathy: An Overlooked Reversible Neurological Sequela of Exocrine Insufficiency of Chronic Pancreatitis With Type 3c Diabetes临床症状性维生素E相关周围神经病变：慢性胰腺炎外分泌功能不全合并3c型糖尿病时被忽视的可逆性神经后遗症DOI: 10.7759/cureus.104766 Curēus IF: 01.300Volume 18, Issue 3No.126A Cross-Sectional Study on the Prevalence and Risk Factors of Steroid-Induced Glaucoma at a Tertiary Eye Care Hospital三级眼科医疗机构中类固醇性青光眼的患病率及危险因素横断面研究DOI: 10.7759/cureus.104759 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.127Risk Stratification of Chronic Kidney Disease in Adults Using Noninvasive Fibrosis Tests Based on the American Diabetes Association Algorithm基于美国糖尿病协会算法的非侵入性纤维化检测对成人慢性肾脏病的风险分层DOI: 10.1111/dom.70730 Medical journal of Australia IF: 08.500Volume 224, Issue 4No.128Deprescribing in Older People: A Clinical Practice Guideline Summary老年人减量停药：临床实践指南摘要DOI: 10.5694/mja2.70174 Annals of African medicine IF: 00.600Ahead of Print.No.129Diagnostic Gaps and Management Hurdles: Central Venous Catheter-related Infections in an End-stage Renal Disease Patient in Nigeria诊断缺口与管理难题：尼日利亚一名终末期肾病患者的中心静脉导管相关感染DOI: 10.4103/aam.aam_206_21 Annals of African medicine IF: 00.600Ahead of Print.No.130Study of Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in Bone Health among Postmenopausal Women绝经后女性骨健康中中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值的研究DOI: 10.4103/aam.aam_841_25 Annals of African medicine IF: 00.600Ahead of Print.No.131Clinical Utility of Using Hematological Markers of Systemic Inflammation as Surrogate Markers for Glycated Hemoglobin in Resource-limited Settings - A Prospective Observational Study在资源有限环境中使用全身性炎症血液学标志物作为糖化血红蛋白替代标志物的临床效用——一项前瞻性观察研究DOI: 10.4103/aam.aam_845_25 Psychology, health & medicine IF: 01.900Ahead of Print.No.132Physical activity is associated with depression and depressive symptoms in US adults with diabetes: a cross-sectional study体力活动与美国成年糖尿病患者的抑郁及抑郁症状相关：一项横断面研究DOI: 10.1080/13548506.2026.2645951 Channels IF: 03.200Volume 20, Issue 1No.133Role of TRPV4 channels in high glucose-induced neurotoxicity in a neuronal-like cell modelTRPV4通道在高糖诱导的类神经元细胞模型神经毒性中的作用DOI: 10.1080/19336950.2026.2654636 Curēus IF: 01.300Volume 18, Issue 3No.134The Diabetic Catalyst: A Rapid 12-Month Evolution of Hepatic Stiffness in a South Indian Cohort With Metabolic Dysfunction-Associated Steatotic Liver Disease糖尿病催化剂：南印度代谢功能障碍相关脂肪性肝病队列中肝硬度12个月的快速演变DOI: 10.7759/cureus.104756 Journal of patient experience IF: 01.800Volume 12, Issue No.135Chatbots and Diabetes: Is There Gender Bias?糖尿病与聊天机器人：是否存在性别偏见？DOI: 10.1177/23743735251380954 Annals of African medicine IF: 00.600Ahead of Print.No.136Role of Advanced Glycation End Product in the Pathogenesis of Diabetic Retinopathy晚期糖基化终产物在糖尿病视网膜病变发病机制中的作用DOI: 10.4103/aam.aam_353_25 Zh Nevrol Psikhiatr Im S S KorsakovaVolume 126, Issue 3. Vyp. 2No.137[Effects of immunological and metabolic parameters on the patient's functional outcome in the acute period of ischemic stroke]免疫学和代谢参数对缺血性卒中急性期患者功能结局的影响DOI: 10.17116/jnevro202612603228 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.138Efficacy and Safety of Olezarsen in Hypertriglyceridemia: An Updated Meta-Analysis of Randomised Controlled TrialsOlezarsen在高甘油三酯血症中的有效性和安全性：一项更新的随机对照试验荟萃分析DOI: 10.1111/dom.70716 Biomolecules & biomedicine IF: 02.200Ahead of Print.No.139Low-dose metformin in the brain: A focused review of its novel mechanism of glucose lowering in type 2 diabetes大脑中的低剂量二甲双胍：针对2型糖尿病降血糖新机制的综述DOI: 10.17305/bb.2026.14097 Curēus IF: 01.300Volume 18, Issue 3No.140Clinical and Comorbidity Profile of Clinically Diagnosed Gout in Two Tertiary Hospitals in Dubai, United Arab Emirates: A Retrospective Observational Study阿联酋迪拜两家三甲医院经临床诊断的痛风患者临床及合并症特征分析：一项回顾性观察研究DOI: 10.7759/cureus.104780 Polish Journal of Microbiology IF: 01.600Volume 75, Issue 1No.141Diabetes Mellitus and Enhanced Vulnerability to Escherichia coli Catheter-Associated Urinary Tract Infections: Integrative Clinical and Molecular Analysis糖尿病与大肠杆菌相关导管相关尿路感染易感性增强：整合临床与分子分析DOI: 10.33073/pjm-2026-010 Curēus IF: 01.300Volume 18, Issue 3No.142Assessing the Effect of Hypothyroidism on Maternal Morbidity and Pregnancy Outcome Among Pregnant Women Attending a Tertiary Care Hospital in Central India: A Prospective Study印度孕妇未控制甲状腺功能减退与母体和胎儿发病率的关联DOI: 10.7759/cureus.104741 Curēus IF: 01.300Volume 18, Issue 3No.143Machine Learning-Based Early Prediction of Gestational Diabetes Using First-Trimester Laboratory Parameters利用合成数据和机器学习的早期妊娠糖尿病预测：综合方法DOI: 10.7759/cureus.104782 Hypertension IF: 08.200Ahead of Print.No.144Adolescent Blood Pressure and Cardiovascular Disease Before Age 50 Years青少年血压与50岁前心血管疾病DOI: 10.1161/HYPERTENSIONAHA.125.26414 Ocul Immunol Inflamm IF: 02.000Ahead of Print.No.145Age-Related Differences in the Etiology and Clinical Characteristics of Uveitis in Japan: A Retrospective Comparative Study日本葡萄膜炎病因与临床特征的年龄相关差异：一项回顾性比较研究DOI: 10.1080/09273948.2026.2648128 142 Diabetes Mellitus(DM) 糖尿病 57 Obesity 肥胖症 26 Insulin 胰岛素 13 Type 2 diabetes mellitus(T2DM) 2型糖尿病 7 Metformin 二甲双胍 7 Metabolic Syndrome 代谢综合征 6 Hypoglycemic Agents 降糖药 5 Semaglutide 司美格鲁肽 5 Diabetic Retinopathy 糖尿病视网膜病 4 Tirzepatide 替尔泊肽 4 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 4 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 3 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 2 Type 1 diabetes mellitus(T1DM) 1型糖尿病 2 Empagliflozin 恩格列净 2 Diabetes Complications 糖尿病并发症 2 Diabetic acidosis 糖尿病性酸中毒 2 Gabapentin 加巴喷丁 1 Diabetic Cardiomyopathies 糖尿病心肌病 1 Diabetic Foot 糖尿病足 1 Diabetic Neuropathies 糖尿病性神经病变 编辑：韩玉莲 审校：韩玉莲