This is a prospective, single-blind, randomized parallel study to investigate whether B. subtilis could improve clinical symptoms of IBS-D patients. Patients are randomly assigned by envelope method. A senior gastroenterologist is responsible for prescribing medication. Researchers are blind to patients' medication. Participants with IBS are recruited and randomized to receive a 4-week administration of B. subtilis-based probiotics. Clinical symptoms and stool samples are collected before and after the trial.

开始日期2024-06-01

申办/合作机构

Nanjing General Hospital of Nanjing Military Command

NCT05658055 / Not yet recruiting临床4期IIT

The Effect of Probiotics With Vonoprazan-amoxicillin Dual Therapy on Gut Microbiotain After Helicobacter Pylori Eradication: A Randomized Controlled Trial

The purpose of this study is to evaluate the effect of probiotics during vonoprazan-amoxicillin dual therapy on the gut microbiota in Helicobacter pylori eradication and to investigate whether the eradication rate of H.pylori will be improved when adding probiotics

开始日期2023-06-01

申办/合作机构

南京医科大学第一附属医院

ChiCTR2000039848 / Recruiting临床4期IIT

The investigation of the effects of Medilac, lactulose and lactulose combined with Medilacon on the intestinal flora and intestinal dynamics in patients with FC

开始日期2020-10-30

申办/合作机构-

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100 项与枯草杆菌二联活菌(Hanmi Pharmaceutical Co., Ltd.) 相关的专利（医药）

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项与枯草杆菌二联活菌(Hanmi Pharmaceutical Co., Ltd.) 相关的文献（医药）

2024-12-01·Plant Physiology and Biochemistry

Unveiling contribution and fate of nitrogen with 15N techniques affected by microbial co-inoculation on field-grown maize: A novel approach to optimize N-fertilizer use efficiency

Article

作者: Heinrichs, Reges ; da Silva, Edson Cabral ; de Lima, Bruno Horschut ; Pagliari, Paulo Humberto ; Bernardes, João Victor Silva ; Teixeira Filho, Marcelo Carvalho Minhoto ; Santos, Gustavo Duprat Dos ; Jalal, Arshad ; Silva, Edson Cabral da ; Thiengo, Cassio Carlette ; Lavres, José ; Vilela, Lucila de Sousa ; Fernandes, Guilherme Carlos ; Galindo, Fernando Shintate ; Oliveira, Carlos Eduardo da Silva ; Oliveira, Carlos Eduardo Silva ; Longato, Pedro Augusto Fedato ; Soares, Deyvison de Asevedo ; Sousa Vilela, Lucila de ; Santos, Gustavo Duprat dos

The objectives of this research were to: i) develop a mechanistic understanding of the synergy between microbial co-inoculation, nitrogen (N) fertilizer, and maize plants on biological ¹⁵N fixation, and ¹⁵N-recovery from applied fertilizers; and ii) explore the mechanist effects of microbial co-inoculation on N fractionations and derivation (fertilizer, atmosphere and soil), physiological responses on water use and carboxylation efficiencies and growth by using two different isotopic techniques under field conditions. Treatments included four seed inoculations (Control, B. subtilis, A. brasilense, and the combination of B. subtilis and A. brasilense), along with five levels of N application (0-240 kg N ha^-1). Overall, the results indicate that maize co-inoculation with the above-mentioned bacteria enhanced photosynthetic efficiency leading to improved carboxylation efficiency and instantaneous water use efficiency in maize plants, likely due to an increase in net photosynthetic rate. This effect was more evident under low N availability. The findings also suggest that co-inoculation enhanced the ability of maize plants to absorb CO₂, adjust to different soil N levels, and carry out photosynthesis, which resulted in higher carbon fixation and better maize growth. The N obtained from the atmosphere resulting from inoculation ranged from 25 to 50 kg N ha^-1. Nonetheless, N application rates exceeding 186 kg N ha^-1 substantially diminished the ability of these bacteria to fix N₂. The combination of inoculation with the application of 120-180 kg N ha^-1 led to a synergistic effect resulting in the greatest N-use efficiency, -recovery and grain yield.

2024-12-01·Poultry Science

Probiotic Bacillus subtilis QST713 improved growth performance and enhanced the intestinal health of yellow-feather broilers challenged with coccidia and Clostridium perfringens

Article

作者: Ding, Xuemei ; Mu, Yadong ; Zhang, Keying ; Liu, Yangbin ; Xiao, Pan ; Peng, Huanwei ; Sun, Lu ; Zeng, Qiufeng ; Li, Shanshan ; Xuan, Yue ; Bai, Shiping ; Wang, Jianping

In this study, we investigated the effects of dietary supplementation with Bacillus subtilis (QST713) on the performance and intestinal health of yellow feather broilers under Coccidia and Clostridium perfringens (CP) challenge or CP alone. One-day-old yellow-feathered broiler roosters (n = 600) were randomly assigned to 5 groups (6 replicates with 20 roosters per replicate): the Con blank group, the CIC.p group (d24 Coccidia+d28-30 of CP challenge), the CIC.p + BS group (CIC.p +100 mg/kg B. subtilis), the C.p group (d 28-34 of CP challenge), and the C.p +BS group (C.p +100 mg/kg B. subtilis). The experiment lasted 80 d. The birds were evaluated for parameters such as average daily gain (ADG), average daily feed intake (ADFI), feed efficiency (F/G), intestinal lesion score, villus histomorphometry, intestinal tight junctions, inflammatory factors, and cecal microorganisms. The results revealed that 1) C.p. increased the F/G of broilers from 22 to 42 d (P < 0.05), whereas CIC.p. significantly decreased the 42 d and 80 d body weights (BW) and 22-42 d and 1-80 d ADG (P < 0.05) and significantly increased the 22 to 42 d and 1 to 80 d F/G (P < 0.05). The number of intestinal lesions significantly increased at 35 d and 42 d (P < 0.05). CIC.p significantly decreased the jejunum and ileum villus height (VH) and the ileum villus height/crypt depth (P < 0.05) at 35 d. The challenge significantly upregulated the expression of Claudin-1 and IL-4 mRNAs in the jejunum at 35 d and significantly downregulated the expression of IL-10 mRNA in the ileum at 35 d (P < 0.05); the number of unique OTUs in the challenge group decreased significantly after challenge treatment, and the relative abundances of Romboutsia at 35 d and Cladomyces and Lactobacillus at 42 d decreased significantly (P < 0.05). 2) Compared with the challenge groups, the addition of BS decreased the F/G of broilers from 22 to 42 d. Compared with the CIC group, the addition of BS significantly increased the F/G of broilers from 22 to 42 d. Compared with that in the CIC.p group, the addition of BS significantly increased the VH in the jejunum and ileum at 35 d (P < 0.05). Compared with the challenge groups, the BS groups presented significantly lower mRNA expression levels of Claudin-1 (P < 0.05) in the jejunum at 35 d. The Shannon and Chao indices suggested that BS increased the alpha diversity of cecum microorganisms in broilers. Dietary supplementation with B. subtilis can alleviate the damage to intestinal morphology and intestinal barrier function, as well as the altered cecal flora structure in broilers caused by Coccidia and C. perfringens infections.

2024-12-01·Poultry Science

Comprehensive efficacy of nano-formulated mixed probiotics on broiler chickens’ performance and Salmonella Typhimurium challenge

Article

作者: Mohamed, Rania I ; Omar, Anaam E. ; Dawod, Rehab E ; Khamis, Tarek ; Habaka, Manal A M ; Baz, Heba A. ; Gad, Wafaa M. ; Habaka, Manal A.M. ; Omar, Anaam E ; El-Hamid, Marwa I. Abd ; Elalfy, Eman. A. ; El-Hamid, Marwa I Abd ; Mohamed, Rania I. ; Elalfy, Eman A ; Elkenawy, Mona E ; Baz, Heba A ; Abdel-Raheem, Sherief M ; Ibrahim, Doaa ; El-Azzouny, Mona M. ; El-Azzouny, Mona M ; Dawod, Rehab E. ; Abdel-Raheem, Sherief M. ; Elkenawy, Mona E. ; Gad, Wafaa M

The increasing recognition of the potential advantages beyond nanoencapsulation of probiotics gained great attention owing to effective properties. Hence, we provided the most in-depth look into the influence of nanoformulated multi strain probiotics; BLB-NPs comprising Bacillus subtilis ATCC19659, Lactobacillus plantarum ATCC8014 and Bifidobacterium bifidum ATCC29521 on growth performance, antioxidant status and intestinal immunity supporting the defense against Salmonella Typhimurium (S. Typhimurium) challenge in broilers chickens. A total of 2,800 one-day-old male Ross 308 boiler chicks were divided into 7 groups; 1 control without additives, 3 probiotics [fed control diets mixed with B. subtilis, L. plantarum and B. bifidum (BLB) at concentrations of 1 × 10⁴ (BLBI), 1 × 10⁶ (BLBII) and 1 × 10⁸ (BLBIII) CFU /kg diet, respectively] and 3 nanoencapsulated probiotics [fed control diets supplemented with BLB loaded nanoparticles (BLB-NPs) at concentrations of 1 × 10⁴ (BLB-NPsI), 1 × 10⁶ (BLB-NPsII) and 1 × 10⁸ (BLB-NPsIII) CFU /kg diet, respectively]. All previous groups were challenged at d 22 of age with S. Typhimurium. Birds fed BLB-NPs II and III exhibited better weight gain and FCR simultaneously with upregulation in nutrients transporters genes (LAT-1, PepT-1, CAT-1 and SGLT1) even after S. Typhimurium challenge. Upregulation of immmune related genes (IL-1β, IL-6, IL-8, MyD88, NF-kB, CCL20, CXCLi2, TLR-2, TLR-4 and SOCS1) was prominently subsided in BLB-NPsIII fed group. The strengthening ability of BLB-NPs for broilers' intestinal barriers was evidenced by augmented expression of JAM, MUC-2, occludin and FABP-2 genes, diminished S. Typhimurium counts and suppressed its virulence related genes (HilA and SopD) with restored histopathological pictures of cecum. Notably, post dietary inclusion of higher levels of BLB-NPsIII, the abundance of beneficial Biofidobacterium and Lactobacillus species was dominated over harmful E. coli ones. Birds fortified with BLB-NPs displayed potent antioxidant potential signified by boosting serum and intestinal antioxidant markers alongside reducing oxidative ones. Overall, the abovementioned positive outcomes of BLB-NPs encouraged their potential application in poultry feed to attain superior performance and elicit protective immunity against S. Typhimurium infection.

项与枯草杆菌二联活菌(Hanmi Pharmaceutical Co., Ltd.) 相关的新闻（医药）

2024-07-19

·立国制药

科普知识丨夏季是腹泻高峰！这些常用中西药可应对！（附联合用药方案）

在夏季，天气闷热潮湿，然而这却给细菌滋生繁殖提供了绝佳时机，稍不注意，我们的胃肠道可能就会遭殃。因此，夏季也是腹泻的高峰期，尤其是急性腹泻。到药店买药需求帮助的急性腹泻患者也会越来越多。今天就来说说夏季腹泻的常用药和联合用药方案。治疗腹泻的常见西药通用型止泻药：蒙脱石散用于成人及儿童急、慢性腹泻。此类药本身不被吸收，药物口服后附着在肠壁，减缓肠蠕动而达到止泻效果。小贴士：在难以分辨急性腹泻的类型时，可以选用通用型的单纯止泻药如蒙脱石散。如果是有便秘者不宜使用。抗菌药物用于细菌感染性腹泻。常见药物举例：盐酸小檗碱、诺氟沙星、呋喃唑酮、环丙沙星等。口服补液盐用于治疗和预防急、慢性腹泻造成的轻度脱水。小贴士：腹泻停止后应立即停用口服补液盐。微生态制剂用于调节肠道菌群，快速构建肠道微生态平衡。常见药物举例：地衣芽孢杆菌活菌制剂、双歧杆菌活菌制剂、乳酸菌素制剂、复方胰酶散、枯草杆菌二联活菌颗粒等。治疗腹泻的常见中成药中医根据辨证将腹泻分为六种类型：肠胃湿热型、寒湿阻滞型、食滞胃肠型、脾胃虚弱型、肾阳虚衰型、肝气乘脾型等等。肠胃湿热型症状：泄泻腹痛，肛门灼热，小便黄，苔黄腻。常用中成药：香连丸、枫蓼肠胃康颗粒。联合用药举例：香连丸＋美沙拉嗪解读：联用美沙拉嗪与香连丸对溃疡性结肠炎患者进行治疗，能显著改善患者的临床症状，减轻其肠道内的炎症反应。寒湿阻滞型症状：腹泻如水，腹痛肠鸣，呕吐清水。苔薄白或白腻，脉濡。常用中成药：藿香正气丸、六合定中丸等。联合用药举例：藿香正气丸＋诺氟沙星解读：临床中治疗急性胃肠炎采用藿香正气丸联合诺氟沙星进行治疗，可有效缩减患者病程，改善治疗效果。但18岁以下患者禁用诺氟沙星，藿香正气水等含有酒精的不推荐联合西药服用。食滞胃肠型症状：腹痛，泻下秽臭，泻后痛减，吐后反快。苔厚腻，脉滑实。常用中成药：保和丸、香连化滞丸、枳实导滞丸等等。脾胃虚弱型症状：神疲乏力，大便溏薄，夹有不消化的食物，舌淡，舌体胖有齿痕。常用中成药：补脾益肠丸、补中益气丸、香砂六君丸、理中丸、固肠止泻丸、参苓白术丸（散）等。肾阳虚衰型症状：五更泄泻，泻前腹痛，泻后腹痛即止，形寒肢冷，舌淡。常用中成药：四神丸、附子理中丸、固本益肠片等等。联合用药：四神丸＋六君子汤解读：四神丸有温肾、暖脾与止泻的功效；六君子汤是调和脾胃与治疗胃肠道疾病的良药方，相合在临床中使用，效果愈佳。肝气乘脾型症状：胸胁胀闷，每因抑郁恼怒或情绪紧张则腹痛泄泻，泻后痛减。舌淡，脉弦。常用中成药：逍遥丸、柴胡舒肝丸等。联合用药：逍遥丸＋诺氟沙星胶囊解读：适用于肝气乘脾型腹泻，中西药结合，疏肝健脾，消炎止泻，但18 岁以下禁服诺氟沙星。来源：药圈网

微生物疗法

2023-01-11

·生物谷

DxVx研究所李守远所长，“微生物组项目，不止于开发”

DxVx将加快步伐推进利用微生物组（microbiome）的新项目。计划结合在诊断领域积累的经验和在国内外积累的微生物组研究能力，提供符合个人特性的差异化解决方案。 DxVx将加快步伐推进利用微生物组（microbiome）的新项目。计划结合在诊断领域积累的经验和在国内外积累的微生物组研究能力，提供符合个人特性的差异化解决方案。 DxVx微生物组研究所是新项目的主力，该研究所由李守远所长领导，李所长从1975年开始一直专注于微生物组研究工作。他是微生物组权威人士，主导了中国北京韩美药品的代表品种乳酸菌理肠剂“妈咪爱”的研发。李所长表示：“在众多标本中筛选有益的菌株并将其商业化是我和研究所的作用”，他强调：“我们利用通过独立的技术实力自行分离·开发的菌株，可以开发产品。” 该公司的微生物组项目由关联公司COREE集团启动。COREE集团是由DxVx的最大股东——韩美药品林钟润社长设立的海外技术资源投资企业。在中国北京设有中央研究所。李守远所长从2012年开始与林钟润社长结缘，并主导了年销售额达到2000亿韩元的妈咪爱成功的本地化和微生物组研究。李所长表示：“基因组检验领域的现有分子遗传研究所加上微生物组研究所，期待协同效应。”，并说道：“DxVx的基因组技术能力结合COREE集团的研究能力，将开发通过个人诊断的针对型保健品或治疗药。” DxVx的微生物组项目以新药和保健品开发双轨进行。新药开发的焦点放在脑疾病或糖尿·肥胖、呼吸器官感染病上。等开发有进展，还可以利用COREE集团的网络，在意大利等地的主要医院进行全球临床试验。李所长表示：“最早研究微生物组时，还没想到会有治疗疾病的可能性，但现在预计会有很多变化。”，并预测：“微生物组治疗药市场有可能比干细胞市场先活跃起来。” 新药开发在确认成果之前需要很长时间，风险很大。对此，DxVx将通过从明年初开始正式开展的保健品项目来进行补充，以此确保创收来源。公司在去年9月份通过收购韩国生物制药准备生产基地等，稳步准备保健品项目的扩展工作。目前设定了肠道健康和糖尿·肥胖辅助剂、呼吸器官免疫力、过敏性皮炎、女性阴道健康乳酸菌等12个类别。计划今年2月份推出呼吸器官免疫力产品，仅上半年就将推出12种产品。李所长表示：“DxVx的保健品项目的最大竞争力是一体化项目结构，即直接生产自主研发的菌株，还可以自行流通。”，并自信地说道：“不仅具备国内市场网络，而且通过COREE集团还具备了全球网络。” DxVx在去年上半年销售额达到130亿韩元，已经超过21年的年销售额。而且，连续两个季度实现营业利润顺差，成功改善了盈利结构，期待公司创立以来的最大业绩。再加上，最近通过178亿韩元规模的招商引资，还为推进新项目提供了动力。李所长表示：“DxVx也拥有从韩美药品延续到COREE集团的‘我的技术’精神。”，并强调：“既然具备了成功实现微生物组产品的商业化的最佳组织和基础，不久将会确认实现增长潜力。”

并购微生物疗法免疫疗法

2022-11-16

·蒲公英Ouryao

27个品规拟取消挂网资格、公示期截止11月22日！

转自：宁夏公共资源中心编辑：wangxinglai20042022年11月15日，宁夏公共资源中心发布了2022年终止挂网药品（第6批）通知，27个品规拟撤销挂网，公示期截止11月22日。通知原文各相关单位:根据《宁夏回族自治区药品阳光挂网实施细则(试行)(宁医保发[2021] 182号)要求,我中心组织开展了2022年终止挂网药品(第六批)审核工作,现将通过审核的药品予以公示。公示期:2022年11月16日至22日,共5个工作日。涉及品种：头孢泊肟酯片、枯草杆菌二联活菌肠溶胶囊、注射用胰激肽原酶、地塞米松磷酸钠注射液、硫酸庆大霉素注射液、苯妥英钠片、腺苷钴胺片、芎菊上清丸、氟尿嘧啶注射液、茶碱缓释片、红花注射液、黄瑞香注射液、阿莫西林克拉维酸钾干混悬剂、复方甘草酸单铵注射液、小儿消食片、硫酸沙丁胺醇口腔崩解片、注射用头孢西丁钠、生脉胶囊、骨筋丸片、双黄连胶囊、消朦胶囊、除障则海甫胶囊、地衣芽孢杆菌活菌颗粒、氨甲苯酸注射液、注射用奥美拉唑钠等；公示期内如有异议,请企业使用CA数字证书,登陆“宁夏医药采购平台”,进入主页“综合服务”,点击“申投诉管理”模块递交申投诉资料,逾期不予受理。联系方式:CA数字证书办理咨询电话: 4008600271转1宁夏医药采购平台技术支持: 0951-6891069区交易服务中心医药招标采购科: 0951-6891057扫描二维码查看原文2022年终止挂网药品（第六批）目录

带量采购核酸药物

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外链

KEGG	Wiki	ATC	Drug Bank
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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
便秘	中国	北京韩美药品有限公司	2002-06-03
腹泻	中国	北京韩美药品有限公司	2002-06-03
消化不良	中国	北京韩美药品有限公司	2002-06-03
肠炎	中国	北京韩美药品有限公司	2002-06-03