预约演示
更新于：2025-05-16
Cyclopentolate Hydrochloride
盐酸环喷托酯
更新于：2025-05-16
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1971-09-23), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H26ClNO3 |
InChIKeyRHKZVMUBMXGOLL-UHFFFAOYSA-N |
CAS号5870-29-1 |
关联
17
项与 盐酸环喷托酯 相关的临床试验TCTR20250312005
The comparative efficacy of a combination of 0.5% cyclopentolate tropicamide, and alternating instillation of 1% cyclopentolate and 1% tropicamide in Thai pediatric refraction
ChiCTR2400084750
Comparison of the effects of pupil dilation and ciliary muscle paralysis of 1% tropicamide, 0.5% tropicamide and 1% cyclopentolate
NCT06077682
Tropicamide Versus Cyclopentolate for Cycloplegic Refraction in Pediatric Patients With Esotropia: A Randomized Clinical Trial
100 项与 盐酸环喷托酯 相关的临床结果
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100 项与 盐酸环喷托酯 相关的转化医学
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100 项与 盐酸环喷托酯 相关的专利（医药）
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708
项与 盐酸环喷托酯 相关的文献（医药）2025-03-03Cureus Journal of Medical Science
A Case of Pediatric Myasthenia Revealed by Marked Eyelid Ptosis After Using Cyclopentolate Eye Drops
Article
作者: Komatsu, Kaori ; Yoshikawa, Tomoko ; Kiuchi, Yoshiaki
Pediatric myasthenia gravis (PMG), while uncommon, poses significant diagnostic challenges due to its potential impact on development and its often subtle initial symptoms, such as ptosis and diplopia. This case report details an unusual presentation of PMG in a three-year-old female, initially diagnosed with a chalazion, highlighting the complexity of diagnosing this autoimmune neuromuscular disorder in children. Despite treatment for the assumed chalazion, the child's ptosis persisted, and disparities in visual acuity between her eyes became evident. The turning point in her diagnosis came during a routine ophthalmologic assessment using cyclopentolate hydrochloride, which exacerbated her ptosis, prompting further neuromuscular investigation. This led to the detection of acetylcholine receptor antibodies and a suspected diagnosis of PMG after a repetitive nerve stimulation test. This case underscores the critical role of detailed clinical observation and the consideration of neuromuscular etiologies in children presenting with ocular symptoms. It also emphasizes the importance of integrating the observations of family members and caregivers into clinical assessments. Oftentimes, subtle symptoms noted by those close to the patient can provide crucial clues in diagnosing complex conditions like PMG. Early detection is paramount to prevent complications such as amblyopia and to initiate timely interventions, as demonstrated by the subsequent implementation of an eye patch to preserve visual function in the affected eye of the patient. This report contributes to the growing literature on the variable presentations of PMG and underlines the necessity for vigilance and a comprehensive approach in pediatric ophthalmologic evaluations to ensure that significant underlying conditions are not overlooked.
2025-03-01OPTOMETRY AND VISION SCIENCE
Comparative efficacy of tropicamide 1% and cyclopentolate 1% for cycloplegic refraction: A systematic review and meta-analysis of randomized controlled trials
Review
作者: Bist, Jeewanand ; Kandel, Sandeep ; Paudel, Nabin ; Marasini, Sanajay
BACKGROUND:
Cyclopentolate 1% is considered the drug of choice for effective cycloplegic refraction in clinical population, although tropicamide 1% is also reported to have similar effects with better tolerability.
OBJECTIVES:
The objective of this meta-analysis was to evaluate the efficacies of tropicamide 1% and cyclopentolate 1% for cycloplegic refraction.
DATA SOURCES:
MEDLINE, Embase, Scopus, and Cochrane Central Register of Controlled Trials were systematically searched for articles published until March 20, 2024.
STUDY ELIGIBILITY CRITERIA, PARTICIPANTS, AND INTERVENTIONS:
Randomized controlled trials that compared tropicamide 1% with cyclopentolate 1% in terms of differences in spherical equivalent refractive errors were included. The meta-analysis included only nonstrabismic participants with no restriction to age.
STUDY APPRAISAL AND SYNTHESIS METHOD:
The included studies were appraised using the Cochrane Risk of Bias Tool-2. The meta-analysis was conducted using the random-effects model with restricted maximum likelihood estimation method.
RESULTS:
Of 17 full-text reviews from 2555 identified studies, 4 randomized controlled trials were included in quantitative synthesis. The meta-analysis included 171 eyes of 171 participants (age range, 4 months to 50 years), in each group, with all types of refractive errors. The results showed no statistically significant differences in mean spherical equivalent refractive error values between the two groups (mean difference, −0.05; standard error, 0.16; p=0.774). There was no heterogeneity observed between the studies (I2 = 0.00%, p=0.93). The outcome did not change when only children were included in the meta-analysis (age range, 4 months to 16 years; mean difference, −0.14; standard error, 0.21; p=0.51). In the risk-of-bias assessment, generally all studies were judged to have low risk of bias, but only one was judged to have low risk of bias across all seven domains.
CONCLUSIONS:
Tropicamide 1% and cyclopentolate 1% showed similar efficacies for cycloplegic refraction in nonstrabismic children and adults. Considering patient tolerability and drug safety, it may be practical to use tropicamide 1% in routine cycloplegic refractions.
2025-01-01OPHTHALMIC AND PHYSIOLOGICAL OPTICS
Impact of proxymetacaine on the dynamics of cyclopentolate in White 6‐ to 7‐year‐olds
Article
作者: Doyle, Megan ; Harrington, Síofra ; O'Dwyer, Veronica
Abstract:
Purpose:
This study compared the efficacy of cyclopentolate hydrochloride at 10‐, 20‐ and 30‐min post‐instillation in White 6‐ to 7‐year‐olds, with and without prior instillation of proxymetacaine hydrochloride. The primary aim was to determine if accurate autorefraction values can be obtained sooner than the current standard of 30‐min post‐cycloplegia. The secondary aim was to investigate whether proxymetacaine hydrochloride enhances the efficiency of cyclopentolate.
Methods:
Participants were 112 White 6‐ to 7‐year‐olds from the Child Eye Health Study. The right eye received 0.5% proxymetacaine hydrochloride and 1.0% cyclopentolate hydrochloride, and the left eye received only 1.0% cyclopentolate hydrochloride. Non‐cycloplegic and cycloplegic refractive error (at 0, 10, 20 and 30 min) was measured using a binocular, open‐field autorefractometer. Data were analysed through paired t‐tests, concordance analysis, linear regression, equivalence testing and Bland–Altman analysis, using the 95% limits of agreement.
Results:
Mean spherical equivalent refraction (SER) (SD) in the right eye at 0‐, 10‐, 20‐ and 30‐min post‐instillation was 0.62 (1.45) D, 1.52 (1.80) D, 1.64 (1.81) D and 1.72 (1.80) D, respectively. Mean left eye SER (SD) were 0.68 (1.24) D, 1.42 (1.66) D, 1.56 (1.66) D and 1.68 (1.72) D, respectively. Bland–Altman analysis showed a high level of agreement, and equivalence testing confirmed that there was no clinically significant difference in SER at 20 and 30 min in both eyes (within ±0.50 D), with mean differences of 0.08 (0.23) D in the right eye and 0.13 (0.30) D in the left eye (p = 0.21). However, SER at 10 and 30 min were equivalent in the right eye only.
Conclusions:
Accurate autorefraction values can be obtained 20‐min post‐instillation of 1.0% cyclopentolate in white children aged 6–7 years, potentially reducing clinical testing times. Proxymetacaine pre‐instillation allows for reliable measurements as early as 10‐min post‐instillation of cyclopentolate. Further research is needed to validate these findings in non‐White populations and to determine the safe discharge time post‐proxymetacaine instillation.
100 项与 盐酸环喷托酯 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 眼部疾病 | 日本 | 1971-09-23 | |
| 睫状肌麻痹 | 美国 | - | - |
| 瞳孔散大 | 美国 | - | - |
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临床结果
临床结果
适应症
分期
评价
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N/A | 3 | (Topical Mydriasis) | 獵製壓窪艱糧蓋鹽艱範(齋製繭築構簾築網鹽憲) = 構鏇鏇襯鹽壓繭鬱憲築 糧鑰憲製鏇顧鏇餘憲衊 (憲襯淵製選觸製簾餘築, 製窪壓淵淵夢夢鹹憲夢 ~ 鹽淵獵積遞襯衊顧襯醖) 更多 | - | 2019-09-10 | ||
(Intracameral Mydriasis) | 鑰鬱窪積簾鹹繭獵醖獵 = 鹹衊製鏇簾衊構膚壓淵 齋繭遞鹽齋獵鑰簾繭壓 (糧簾衊願衊繭繭選願夢, 廠襯襯鹹鹹簾鹽鑰構鹹 ~ 鏇壓獵淵艱觸壓繭網鬱) 更多 | ||||||
N/A | 25 | 鬱製鏇繭憲遞網築繭鑰(艱憲繭鑰醖範糧顧顧襯) = Preterm infants undergoing Retinopathy of Prematurity Eye Exams (ROPEE) may experience adverse events, possibly from systemic absorption of cyclopentolate. 築築築憲醖築遞繭衊鑰 (構鑰鑰廠鏇廠艱齋憲鏇 ) 更多 | - | 2016-12-01 | |||
N/A | - | 8 | 遞鬱觸製願夢構獵構願(網糧醖鹹醖鏇鑰積構繭) = 簾窪襯膚鏇積鏇鬱鹽遞 網夢繭鑰餘蓋餘壓衊遞 (簾簾鏇築鏇衊窪願獵淵 ) 更多 | - | 2015-06-01 | ||
N/A | 1,246 | Phenylephrine 2.5% with Cyclopentolate 0.5% | 醖選醖顧遞遞鏇齋齋鹽(選構觸蓋窪鬱夢鬱夢構) = 鬱憲範襯鏇餘糧願獵鑰 鏇夢齋顧鹽顧網鹹繭齋 (襯蓋糧壓醖積願糧鏇製 ) | - | 2015-05-01 | ||
N/A | 28 | (Myopic children) | 壓選齋鑰積鑰選衊鏇襯(夢餘窪壓艱製觸餘壓鑰) = 製範齋遞鬱築鬱顧襯構 顧範願鏇壓餘顧簾齋構 (構鏇選憲蓋餘鹽築獵製 ) 更多 | - | 2013-06-01 | ||
N/A | - | 67 | 憲鏇廠鹽蓋壓齋網簾齋(壓鬱壓獵範選餘遞鹽糧) = 窪壓窪積鏇鹹夢願壓選 選膚獵顧窪鹽廠衊獵獵 (糧製艱憲鏇鑰衊窪齋簾 ) 更多 | 积极 | 2011-02-01 | ||
憲鏇廠鹽蓋壓齋網簾齋(壓鬱壓獵範選餘遞鹽糧) = 遞製糧構艱願繭選襯膚 選膚獵顧窪鹽廠衊獵獵 (糧製艱憲鏇鑰衊窪齋簾 ) 更多 | |||||||
N/A | 24 | 獵遞壓觸廠選廠夢窪顧(簾壓遞製範製艱淵選築) = 遞願窪夢艱膚醖醖獵齋 簾齋鹹簾醖構淵膚獵廠 (獵鹽網憲淵製艱膚夢衊, 0.85) 更多 | 积极 | 2008-05-01 | |||
獵遞壓觸廠選廠夢窪顧(簾壓遞製範製艱淵選築) = 襯襯鏇簾醖鏇餘齋憲醖 簾齋鹹簾醖構淵膚獵廠 (獵鹽網憲淵製艱膚夢衊, 0.85) |
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