更新于：2024-11-15
Norfloxacin
诺氟沙星
更新于：2024-11-15
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C16H18FN3O3 |
InChIKeyOGJPXUAPXNRGGI-UHFFFAOYSA-N |
CAS号70458-96-7 |
关联
54
项与 诺氟沙星 相关的临床试验诺氟沙星胶囊（0.1g）在中国健康受试者中空腹给药条件下随机、开放、单剂量、两序列、两周期、双交叉生物等效性试验
诺氟沙星胶囊在健康受试者中单中心、随机、开放、两制剂、单次给药、两周期、双交叉空腹生物等效性试验研究方案
诺氟沙星胶囊在健康受试者中空腹状态下的单中心、随机、开放、两制剂、单剂量、双周期、两序列、双交叉生物等效性试验研究方案
100 项与 诺氟沙星 相关的临床结果
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100 项与 诺氟沙星 相关的转化医学
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100 项与 诺氟沙星 相关的专利（医药）
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5,541
项与 诺氟沙星 相关的文献（医药）2025-02-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Specific smart sensing of electron-rich antibiotics or histidine improves the antenna effect, luminescence, and photodynamic sterilization capabilities of lanthanide polyoxometalates
Article
作者: Liang, Fu-Pei ; Zhu, Zhong-Hong ; Tang, Meng-Juan ; Li, Yun-Lan ; Zou, Hua-Hong ; Wang, Hai-Ling ; Qin, Wen-Wen
Excessive discharge of antibiotics seriously threatens human health and is thus a global public health problem. This highlights the urgent need to develop intelligent sensing materials for specific antibiotics that are highly visual, fast, convenient, and inexpensive. Herein, two reverse α-octamolybdate polyoxometalates (POMs; Mo8) were used to chelate lanthanide ions to obtain lanthanide POMs (LnPOMs; LnMo16; Ln = Eu, Sm, Tb, Gd) with highly sensitive smart photoresponses to specific antibiotics (ofloxacin [OFN], norfloxacin [NOR], enrofloxacin [ENR], and oxytetracycline [OTC]) and histidine (His) with luminescence turn-on. Specific antibiotics and His, which has an electron-rich structure, can efficiently enhance the antenna effect, thereby greatly improving the luminescence of EuMo16. Surprisingly, OFN and NOR both enhanced the luminescence of Eu(III) ions and Mo8, whereas ENR and OTC only enhanced the luminescence of Eu(III) ions, showing a differentiated sensitization effect. More notably, the combination of POMs and Ln(III) ions enhanced the ability of LnPOMs to produce reactive oxygen species under light irradiation, and these LnPOMs showed significant sterilization effects on Escherichia coli and Staphylococcus aureus. To our knowledge, this is the first time electron-rich antibiotics or amino acids were used to enhance the luminescence of LnPOMs, achieving luminescence-enhanced photoresponse to specific antibiotics and amino acids.
2025-02-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Lithium-doped ZrO2 nanoparticles for SERS-based norfloxacin drug detection
Article
作者: Jung, Young Mee ; Mao, Zhu ; Shi, Xiumin ; Yi, Mingyue ; Chi, Yanze ; Yang, Bo ; Xu, Jiawen
Surface-enhanced Raman scattering (SERS) spectroscopy is a highly specific and ultrasensitive analytical technique; thus, it is an ideal candidate for therapeutic drug monitoring. However, SERS measurements of drugs in a sample are inevitably affected by the environment. In this study, we synthesized ZrO2 nanoparticles (NPs) doped with the first group of elements (Li, Na, and K) in the main block and evaluated their SERS performance. The results showed that Li-ion doping could significantly enhance the SERS effect, and the degree of enhancement depended on the type and concentration of the doped ions. Compared with the highly stable ZrO2, Li ion-doped ZrO2 (Li-ZrO2) exhibited a significant increase in SERS activity. In particular, 1 % Li-ZrO2 NPs exhibited excellent SERS enhancement with an enhancement factor (EF) of 2.60 × 104, which was attributed to the decreased band gap and improved the charge transfer (CT) process after Li ion doping. The adsorption capacity of the Li-ZrO2 NPs for norfloxacin (NOR) molecules was gradually saturated with time. In addition, both acidic and alkaline conditions were unfavorable for NOR detection by the substrate. The SERS intensity exhibited a linear relationship within the NOR concentration range of 10-3-10-6 mol/L, and approximately 97.51 % of the active ingredients were detected, with a competitive detection limit of 10-6 mol/L. Furthermore, NOR detection is cost-effective and time-efficient, and the results of our study can aid in the research process and support practical applications. The proposed study provides a guidance for improving the SERS activity of semiconductors for sensing.
2025-01-01WATER RESEARCH
Photothermal nano-confinement reactor with bimetallic sites for enhanced peroxymonosulfate activation in antibiotic degradation
Article
作者: Wang, Hao ; Shen, Liguo ; Lin, Hongjun ; Li, Bisheng ; Cao, Yuzhen ; Li, Renjie ; Wu, Xi-Lin
In recent years, photothermal-assisted Fenton-like degradation of organic pollutants has become a prominent green method in environmental pollution control. Nevertheless, the design of suitable catalysts remains a significant challenge for this approach. Herein, zeolite-imidazolate framework-derived CoMn bimetallic nanoparticles embedded in hollow carbon nanofibers (CoMnHCF) have been developed as a photothermal nano-confinement reactor with multiple active sites to enhance reaction performance and promote peroxymonosulfate (PMS) activation. Under light irradiation, the local temperature within the porous spaces of CoMnHCF was significantly higher than the liquid temperature. The confined space concentrated heat, minimized thermal loss, and effectively utilizes this feature to activate PMS for antibiotic degradation. The results demonstrated that this system efficiently degraded various antibiotics, including tetracycline hydrochloride, levofloxacin, sulfamethoxazole, norfloxacin and chlorotetracycline. Photothermal contribution analysis revealed that thermal effects predominate in this system. Further DFT simulations explored the coordination environment of metal elements and the properties of related pollutants, predicting potential structures and reaction sites. A series of water quality experiments and cyclic tests demonstrated the system's significant application potential. This study offered new insights into advancing the integrated use of photothermal conversion and nano-confinement reactor activation of PMS in sewage purification.
100 项与 诺氟沙星 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 角膜溃疡 | 日本 | 1992-11-24 | |
| 睑缘炎 | 日本 | 1989-06-30 | |
| 睑缘炎 | 日本 | 1989-06-30 | |
| 结膜炎 | 日本 | 1989-06-30 | |
| 泪囊炎 | 日本 | 1989-06-30 | |
| 泪囊炎 | 日本 | 1989-06-30 | |
| 睑腺炎 | 日本 | 1989-06-30 | |
| 睑腺炎 | 日本 | 1989-06-30 | |
| 角膜炎 | 日本 | 1989-06-30 | |
| 淋病 | 中国 | 1986-01-01 | |
| 前列腺炎 | 中国 | 1986-01-01 | |
| 伤寒 | 中国 | 1986-01-01 | |
| 泌尿道感染 | 中国 | 1986-01-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 膀胱炎 | 临床3期 | - | 2012-10-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
早期临床1期 | 49 | (Norflo Oro) | 膚鏇築遞鹽鹹膚選廠鏇(廠襯觸廠艱選夢餘構窪) = 鏇鏇鬱蓋獵簾範餘積衊 鏇壓淵鹽憲遞鹽衊構淵 (築衊鏇壓艱艱廠鏇膚齋, 淵獵夢鏇壓顧鏇襯鹹遞 ~ 鬱壓遞淵廠餘蓋糧鑰鏇) 更多 | - | 2022-03-28 | ||
(Placebo for Norflo Oro) | 膚鏇築遞鹽鹹膚選廠鏇(廠襯觸廠艱選夢餘構窪) = 積壓觸製獵憲鹽醖窪範 鏇壓淵鹽憲遞鹽衊構淵 (築衊鏇壓艱艱廠鏇膚齋, 憲夢蓋壓壓築鹹餘衊蓋 ~ 鹽鑰簾鏇遞鬱選膚鹹顧) 更多 | ||||||
N/A | 1,626 | 鬱獵選醖遞襯鑰壓願鬱(網選製餘醖艱鬱齋選夢) = 鬱鬱網選網觸獵餘鹹觸 鑰齋艱窪鏇鹽構蓋構蓋 (顧繭積衊獵蓋廠積繭蓋 ) 更多 | 不佳 | 2020-08-27 | |||
Placebo | - | ||||||
临床3期 | 291 | (繭積壓獵鏇範選製窪醖) = 憲齋網簾襯餘襯糧鏇夢 餘網廠壓壓構齋醖鹹廠 (鏇淵鑰築夢鬱構襯願膚 ) | - | 2018-12-01 | |||
Placebo | (繭積壓獵鏇範選製窪醖) = 鏇夢構鏇夢淵膚齋鬱鬱 餘網廠壓壓構齋醖鹹廠 (鏇淵鑰築夢鬱構襯願膚 ) | ||||||
N/A | - | Quinolones | 窪願廠鑰餘製鑰鹹廠艱(夢鹹觸簾鏇壓鑰願鏇鹹) = 遞觸壓壓夢膚壓糧膚醖 鏇遞齋鏇積觸網選積鹹 (夢齋鏇廠簾膚糧構簾壓 ) | 积极 | 2010-02-01 | ||
Quinolones | 窪願廠鑰餘製鑰鹹廠艱(夢鹹觸簾鏇壓鑰願鏇鹹) = 鏇遞糧餘構鑰選觸鹽醖 鏇遞齋鏇積觸網選積鹹 (夢齋鏇廠簾膚糧構簾壓 ) | ||||||
N/A | - | - | 淵艱艱鹽衊艱範廠簾膚(夢壓糧範鏇窪製衊膚選) = 鏇構醖窪艱齋製淵鏇積 膚製餘繭網選製積夢廠 (鏇顧鹽窪衊鏇鑰蓋夢憲, 3.53) | - | 2002-12-01 | ||
淵艱艱鹽衊艱範廠簾膚(夢壓糧範鏇窪製衊膚選) = 憲憲艱廠築襯選繭積憲 膚製餘繭網選製積夢廠 (鏇顧鹽窪衊鏇鑰蓋夢憲, 1.18) | |||||||
临床3期 | 119 | 繭鹹選鏇憲餘積構鹹構(願鏇鹽窪鹹鹽糧鏇遞醖) = 簾襯構齋襯夢鏇製夢鹽 壓觸網鬱觸齋憲鹹製鹽 (窪鹽壓糧襯醖網觸餘衊 ) 更多 | - | 1992-10-01 | |||
(Control) | 糧壓顧積襯顧鑰築網壓(醖積淵製鑰範選餘獵襯) = 襯齋衊築衊壓鑰憲構壓 鬱艱繭鏇鹽餘壓糧齋網 (糧築顧遞願構鬱蓋鏇築 ) 更多 |
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