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更新于：2024-12-27
Norfloxacin
诺氟沙星
更新于：2024-12-27
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 日本 (1984-02-15), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H18FN3O3 |
InChIKeyOGJPXUAPXNRGGI-UHFFFAOYSA-N |
CAS号70458-96-7 |
关联
55
项与 诺氟沙星 相关的临床试验CTR20241157
诺氟沙星胶囊（0.1g）在中国健康受试者中空腹给药条件下随机、开放、单剂量、两序列、两周期、双交叉生物等效性试验
CTR20240282
诺氟沙星胶囊在健康受试者中单中心、随机、开放、两制剂、单次给药、两周期、双交叉空腹生物等效性试验研究方案
CTR20230089
诺氟沙星胶囊在健康受试者中空腹状态下的单中心、随机、开放、两制剂、单剂量、双周期、两序列、双交叉生物等效性试验研究方案
100 项与 诺氟沙星 相关的临床结果
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100 项与 诺氟沙星 相关的转化医学
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100 项与 诺氟沙星 相关的专利（医药）
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5,665
项与 诺氟沙星 相关的文献（医药）2025-03-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Electro-activated peroxymonosulfate based on hollow cubic skeleton nanoflower cathode catalyst MoSe2/cubic nanocage (CNC) for enhanced degradation of norfloxacin: Performance, mechanism, degradation pathways and toxicity
Article
作者: Fan, Zhirui ; Song, Peipei ; Liu, Jin
Recently, antibiotic wastewater pollution has become increasingly serious. In this study, a novel hollow cubic framework self-supported nanoflower-like cathode catalyst (MoSe2/CNC) based on Co Fe prussian blue analogues (CoFePBA)-derived cubic nanocage (CNC) loaded with MoSe2 was successfully prepared and utilized in an electro-activated peroxymonosulfate (PMS) system for norfloxacin (NOR) degradation. Benefit from the combined structures of MoSe2, MoC, and Co/FeNC, the electrocatalytic activity and specific surface area were greatly improved. The effects of catalyst dosage and ratio, current, PMS concentration, electrolyte type, pH, as well as initial concentration were comprehensively investigated. Under the optimal conditions, NOR and TOC removal reached 92.70% and 82.17%, respectively, which was superior to the previous studies. Additionally, ·O2- was proved to be the primary reactive species for NOR degradation.·Based on density functional theory (DFT) and intermediates analysis, NOR underwent substitution and ring-opening reactions in the piperazine ring, substitution of fluoride ions, and cleavage of the carboxyl group and tetrahydropyridine ring, ultimately converting into water, carbon dioxide, and inorganic ions. Moreover, toxicity assessment and seed germination experiments demonstrated that the toxicity of NOR and intermediates were strongly decreased by electro-activated PMS system based on MoSe2/CNC cathode. Overall, this study not only contributes to the evolution of efficient and sustainable wastewater purification technology, but also provides valuable insights into the degradation of antibiotic wastewater.
2025-03-01JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Evaluation of inhibition and eradication of bacterial biofilm by solasodin
Article
作者: da Silva, Ana Raquel Pereira ; de Alencar, Maria Anésia Sousa ; Coutinho, Henrique Douglas Melo ; Barbosa-Filho, José Maria ; Andrade-Pinheiro, Jacqueline Cosmo ; Costa, Maria do Socorro ; Paulo, Cícera Laura Roque ; Araújo, Nara Juliana Santos ; de Freitas, Thiago Sampaio
Biofilms are complex microbial structures that have a significant impact on human health, industry and the environment. These complex structures represent one of the main mechanisms of microbial resistance, and their development constitutes a serious health problem. Therefore, the aim of this study was to verify the potential for inhibition and eradication of bacterial biofilm by salosodine, which is a steroidal alkaloid sapogenin found in plants of the Solanum genus. The antibiotics gentamicin, norfloxacin, ampicillin and the antiseptic agent chlorhexidine gluconate were used as positive controls to compare the results. Solasodin showed significant results in inhibiting the formation of Enterococcus faecalis and Staphylococcus aureus biofilms at the two concentrations tested. And when comparing the effect of solasodine for the two concentrations and the effect of the antibiotic gentamicin, it was found that sapogenin showed a better percentage in inhibiting E. faecalis biofilm formation. And against Pseudomonas aeruginosa, solasodine only inhibited biofilm formation at the highest concentration compared to the control. In the biofilm eradication results, solasodine showed a significant reduction in the biomass of the S. aureus biofilm, and when compared with the percentage reduction of the antibiotics, solasodine showed a relevant result for both concentrations. Only at the lowest concentration did solasodine show a reduction in P. aeruginosa biofilm biomass, a reduction close to that of chlorhexidine gluconate. In terms of activity, solasodine has been shown to have the potential to inhibit biofilm formation. However, further tests are needed to investigate the mechanisms of action of this sapogenin on the bacterial biofilms tested.
2025-03-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
A new molecularly imprinted nanocatalytic probe for RRS determination of trace enrofloxacin based on covalent organic framework polymer
Article
作者: Wen, Guiqing ; Li, Jingjing ; Jiang, Zhiliang ; Liang, Aihui
A new nanopalladium surface molecularly imprinted covalent organic framework (MICOF) catalytic probe (Pd@TpPa) for enrofloxacin (ENR) was synthesized by molecular imprinting technology, using 1,3,5-triformylphloroglucinol (Tp) and p-phenylenediamine (Pa) as monomers, ENR as the template molecule, and palladium nanoparticles (PdNP) as the core of nanocatalytic probe. This nanoprobe not only specifically recognizes ENR but also catalyzes the cupric tartrate-glucose (GL) indicator reaction. The amino groups in TpPa replace the tartrate ions, forming a new complex with Cu2+. This new complex enhances the efficiency of GL oxidation reaction. The generated Cu2O nanoparticles exhibit strong resonance Rayleigh scattering (RRS) and absorption (Abs) peaks at 370 nm and 500 nm, respectively. The catalytic and analytical performances of metal nanoparticles including Pd, Pt, Au and Ag were studied. It was found that Pd@TpPaENR exhibited the best performance. The RRS response was linear to ENR concentration in the range of 0.01-1.5 nM, with a detection limit of 0.008 nM ENR. The method was applied to analyze river water samples, yielding recoveries of 96.9-106.6 % and precision between 2.33-8.49 %. This nanocatalytic probe-RRS analysis platform is simple, sensitive, selective, and versatile, making it applicable for the determination of norfloxacin (NOR), ofloxacin, pefloxacin, fleroxacin, and ciprofloxacin, with linear ranges of 0.02-6.0 nM, 0.04-6.0 nM, 0.04-6.0 nM, 0.1-15 nM, and 0.1-15 nM, respectively.
100 项与 诺氟沙星 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 志贺氏菌感染 | 澳大利亚 | 2001-11-13 | |
| 胃肠道感染 | 澳大利亚 | 2001-11-13 | |
| 旅行者腹泻 | 澳大利亚 | 2001-11-13 | |
| 角膜溃疡 | 日本 | 1992-11-24 | |
| 睑缘炎 | 日本 | 1989-06-30 | |
| 睑缘炎 | 日本 | 1989-06-30 | |
| 结膜炎 | 日本 | 1989-06-30 | |
| 泪囊炎 | 日本 | 1989-06-30 | |
| 泪囊炎 | 日本 | 1989-06-30 | |
| 睑腺炎 | 日本 | 1989-06-30 | |
| 睑腺炎 | 日本 | 1989-06-30 | |
| 角膜炎 | 日本 | 1989-06-30 | |
| 淋病 | 中国 | 1986-01-01 | |
| 前列腺炎 | 中国 | 1986-01-01 | |
| 沙门氏菌感染 | 中国 | 1986-01-01 | |
| 伤寒 | 中国 | 1986-01-01 | |
| 泌尿道感染 | 中国 | 1986-01-01 | |
| 感染 | 日本 | 1984-02-15 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 膀胱炎 | 临床3期 | - | 2012-10-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
早期临床1期 | 49 | (Norflo Oro) | 繭齋膚艱構範艱衊願鬱(繭襯餘憲艱鬱願襯鬱壓) = 範夢築醖醖顧觸願膚範 醖選繭醖顧獵齋鏇窪醖 (願齋膚製憲醖獵獵糧憲, 範構窪餘夢壓糧餘選積 ~ 廠襯選衊艱鹽鏇鏇鹹餘) 更多 | - | 2022-03-28 | ||
(Placebo for Norflo Oro) | 繭齋膚艱構範艱衊願鬱(繭襯餘憲艱鬱願襯鬱壓) = 窪鹹簾鏇窪鑰餘壓窪襯 醖選繭醖顧獵齋鏇窪醖 (願齋膚製憲醖獵獵糧憲, 襯齋鹹選顧構艱繭築夢 ~ 選衊遞簾窪顧積壓遞餘) 更多 | ||||||
N/A | 1,626 | 範鹹醖獵艱醖積鏇餘窪(窪鬱選餘鹹齋齋膚選憲) = 糧範淵蓋獵積鏇獵網醖 廠壓顧遞餘積範壓繭網 (願範膚衊顧齋窪憲膚夢 ) 更多 | 不佳 | 2020-08-27 | |||
Placebo | - | ||||||
临床3期 | 291 | 遞壓願淵餘憲餘齋艱遞(餘積衊範窪艱觸壓壓壓) = 餘鑰夢製顧積壓鏇願憲 願網鹽築構積鑰選窪糧 (夢鏇糧鏇繭廠範襯襯艱 ) | - | 2018-12-01 | |||
Placebo | 遞壓願淵餘憲餘齋艱遞(餘積衊範窪艱觸壓壓壓) = 構壓獵夢壓網壓壓壓蓋 願網鹽築構積鑰選窪糧 (夢鏇糧鏇繭廠範襯襯艱 ) | ||||||
临床2期 | 9 | Placebo | 製範廠蓋壓鬱艱積構憲(蓋醖鹹願簾鑰簾蓋積窪) = 網齋蓋廠憲構鬱鏇糧願 顧顧顧獵糧醖衊簾遞鏇 (積窪顧顧鹹醖壓觸網遞 ) | - | 2010-12-01 | ||
N/A | - | Quinolones (Anaphylaxis patients) | 鬱觸願鹽積簾遞膚鹹繭(膚襯淵構廠簾憲窪夢窪) = 網觸夢選憲鏇顧獵襯遞 積憲鏇鹽願獵鬱繭觸夢 (網鬱襯憲餘顧鑰蓋淵鬱 ) | 积极 | 2010-02-01 | ||
Quinolones (Urticaria patients) | 鬱觸願鹽積簾遞膚鹹繭(膚襯淵構廠簾憲窪夢窪) = 選壓窪壓獵願蓋壓壓網 積憲鏇鹽願獵鬱繭觸夢 (網鬱襯憲餘顧鑰蓋淵鬱 ) | ||||||
N/A | - | - | 膚蓋窪網選淵遞構齋鏇(鹽餘顧範顧夢築獵衊餘) = 繭憲夢齋餘範鏇繭範範 繭繭積選鬱鹽鬱範糧艱 (繭簾淵網鬱選構壓鏇廠, 3.53) | - | 2002-12-01 | ||
膚蓋窪網選淵遞構齋鏇(鹽餘顧範顧夢築獵衊餘) = 膚願艱衊繭製窪鏇壓願 繭繭積選鬱鹽鬱範糧艱 (繭簾淵網鬱選構壓鏇廠, 1.18) | |||||||
临床3期 | 119 | 鑰壓鬱觸構鏇襯餘網憲(獵鬱鏇積鏇餘選蓋壓齋) = 顧遞積簾鏇壓遞鹹繭製 顧鹹製鹽蓋廠淵顧網壓 (膚鬱鏇鑰觸鏇餘廠醖網 ) 更多 | - | 1992-10-01 | |||
(Control) | 餘艱壓廠範壓鹽糧餘築(積觸艱廠鏇範構範膚夢) = 鬱衊鬱膚糧醖憲鏇襯醖 窪鏇遞網積範觸醖願鹹 (鏇餘膚簾襯範獵廠廠選 ) 更多 |
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