预约演示
更新于：2026-06-29
Chloral Hydrate
水合氯醛
更新于：2026-06-29
概要
基本信息
原研机构- |
在研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 中国 (2019-12-30), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C2H3Cl3O2 |
InChIKeyRNFNDJAIBTYOQL-UHFFFAOYSA-N |
CAS号302-17-0 |
关联
54
项与 水合氯醛 相关的临床试验ChiCTR2600124590
Comparison of Emergence Quality Following Different Sedation Regimens for Magnetic Resonance Imaging in Infants: A Prospective Randomized Controlled Study
ChiCTR2600121358
A randomized, non-inferiority clinical trial on the safety and efficacy of midazolam oral solution combined with dexmedetomidine for sedation in children undergoing magnetic resonance imaging examinations
CTR20253105
SH081012口服用浓溶液在中国健康受试者中单中心、开放、随机、单剂量、交叉的药代动力学比较研究
100 项与 水合氯醛 相关的临床结果
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100 项与 水合氯醛 相关的转化医学
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100 项与 水合氯醛 相关的专利（医药）
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3,286
项与 水合氯醛 相关的文献（医药）2026-08-01JOURNAL OF NEUROSCIENCE METHODS
Chloral Hydrate versus Isofluorane anesthesia and their differential impact on the midbrain system
Article
作者: Grace, A A ; Hamza, A
BACKGROUND:
Isoflurane (ISO) has become one of the most commonly used anesthetics for animal surgery, has largely replaced chloral hydrate (CH). Despite this shift, the physiological consequences of these anesthetics on dopamine neuron (DA) function have not been directly compared. This is particularly relevant for DA neurons in the ventral tegmental area (VTA), a critical network involved in reward and motivation.
NEW METHOD:
In this study, we compared the electrophysiological properties of VTA DA neurons under CH and ISO anesthesia in male and female rats. Extracellular recordings were used to assess population activity, mean firing rate, and phasic burst firing across medial, central, and lateral VTA regions. Relative frequency distributions of firing rate and spikes per burst were also assessed.
RESULTS:
Measures of population activity, mean firing rate using extracellular recordings of the population, and relative frequency distributions of firing rate, as well as spikes per burst, were assessed. With either anesthetic, active neurons and firing rate distributions were comparable. The percentage of spikes fired in bursts was also similar between ISO and CH. In addition, the relative frequency of both spikes in bursts and firing rate was the same. Furthermore, the population activity and VTA subregion differences in both groups were the same.
COMPARISON WITH EXISTING METHODS:
The electrophysiological profiles of VTA dopamine neurons obtained under ISO anesthesia closely matched those recorded under CH.
CONCLUSIONS:
These findings demonstrate that CH and ISO exert comparable effects on the baseline electrophysiological properties of VTA DA in vivo.
2026-06-01BRITISH JOURNAL OF PSYCHIATRY
Drugs for anxiety: from chloral hydrate to novel therapeutics
Article
作者: Haddad, Peter M.
Summary:
Anxiety disorders are common and disabling. Current drugs have limited efficacy, notable side-effects and little innovation. This editorial briefly reviews past, current and emerging anxiolytic treatments, including psychedelic-assisted therapies, and highlights key themes. There remains a major need for improved medications to reduce disability and improve quality of life.
2026-05-01ACTA BIOCHIMICA ET BIOPHYSICA SINICA
The DNA-PKcs-primary cilia axis maintains ionizing radiation-induced senescence in tumor cells
Article
作者: Wang, Jufang ; Wei, Li ; Xie, Xiaodong ; Chen, Jiaxin ; Hua, Junrui ; Zhang, Tongshan ; Zhang, Rong ; Liu, Xiuzhu ; He, Jinpeng
Senescence is a cellular response closely associated with genotoxic stress and plays a critical role in determining cell fate following irradiation exposure. Primary cilia, which are sensory organelles on the cell surface, detect and transmit diverse signaling cues. However, the relationship between primary cilia and senescence in long-term cell fate decisions after ionizing radiation remains poorly understood. Here, we show that the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) colocalizes with centromeres during various stages of mitosis, whereas during interphase, phosphorylated DNA-PKcs (p-DNA-PKcs) is confined to the nucleus in tumor cells. Following irradiation exposure, primary cilia are formed and persistently maintained at high levels in senescent tumor cells. Inhibition of DNA-PKcs enhances primary cilia formation, whereas combined inhibition with siDNA-PKcs and irradiation reduces cilia generation. Moreover, chloral hydrate-induced primary cilia removal results in senescent cell death and decreases p-DNA-PKcs protein expression. Notably, treatment with the apoptosis inducer ABT263 also leads to increased cell death and decreased incidence of primary cilia. Inhibition of either primary cilia or DNA-PKcs further enhances the radiosensitivity of tumor cells. These findings suggest that DNA-PKcs contributes to primary cilia formation after irradiation and plays a critical role in both the induction and maintenance of cellular senescence.
100 项与 水合氯醛 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 镇静 | 中国 | 2019-12-30 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 96 | 鏇壓簾窪壓艱襯餘夢餘(觸繭窪積艱願鏇繭艱艱) = 鹽膚觸衊鬱願範衊夢顧 選窪壓醖獵獵窪餘顧獵 (憲憲積繭鬱鏇鬱簾蓋壓, -12.12 ~ -9.47) 更多 | 积极 | 2026-05-01 | |||
临床4期 | 158 | Second oral dose chloral hydrate 25 mg/kg | 築願糧選築築簾鬱淵糧(選鏇觸顧壓遞廠遞鏇範) = 艱簾顧顧蓋願遞廠鏇餘 網淵壓積網鑰構積構鑰 (餘繭繭齋夢壓醖艱鏇繭 ) | - | 2016-03-01 | ||
Intranasal dexmedetomidine 1 mcg/kg | 築願糧選築築簾鬱淵糧(選鏇觸顧壓遞廠遞鏇範) = 壓壓壓醖醖獵憲製淵觸 網淵壓積網鑰構積構鑰 (餘繭繭齋夢壓醖艱鏇繭 ) | ||||||
临床4期 | 90 | Placebo+Dexmedetomidine (Oral Placebo and Intransal Dexmedetomidine) | 襯廠夢積壓憲簾夢衊窪(鬱憲顧築糧蓋願鑰鏇構) = 願餘顧鑰積築鹽遞襯願 觸顧齋廠網鑰觸鹽鹽築 (壓壓襯獵鏇齋積餘築觸, 鏇遞衊餘獵淵積糧齋醖 ~ 顧衊夢壓製鑰淵鑰鬱積) 更多 | - | 2016-02-22 | ||
Placebo+Chloral Hydrate (Oral Chloral Hydrate and Intranasal Placebo) | 襯廠夢積壓憲簾夢衊窪(鬱憲顧築糧蓋願鑰鏇構) = 顧廠範網範衊齋構廠鹽 觸顧齋廠網鑰觸鹽鹽築 (壓壓襯獵鏇齋積餘築觸, 遞廠遞蓋淵網齋艱遞積 ~ 鹹襯製顧膚遞蓋窪襯鏇) 更多 | ||||||
临床1/2期 | - | 27 | (Therapeutic Chloral Hydrate and DCA (2A)) | 鑰餘構顧壓範鑰選製範(選鹽壓遞鏇鹽膚遞網簾) = 築蓋醖餘鹹範築襯製餘 鹹淵衊醖構構膚鹹鹽網 (憲夢獵簾鹽築鏇襯構糧, 0.40) 更多 | - | 2014-05-07 | |
(Therapeutic Chloral Hydrate (2B)) | 願膚鏇製廠蓋構蓋鹽艱(壓網窪網鏇簾醖鑰觸廠) = 醖繭遞獵築積蓋糧鏇簾 壓獵壓鏇願鬱艱淵鑰繭 (繭網醖餘顧選鹽遞鑰網, 1403) 更多 |
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