预约演示
更新于：2025-05-16
Chloral Hydrate
水合氯醛
更新于：2025-05-16
概要
基本信息
原研机构- |
在研机构 |
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 中国 (2019-12-30), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C2H3Cl3O2 |
InChIKeyRNFNDJAIBTYOQL-UHFFFAOYSA-N |
CAS号302-17-0 |
关联
33
项与 水合氯醛 相关的临床试验NCT06606899
A Comparative Study Between Efficacy of Combined Oral Melatonin With Nasal Sevoflurane Versus Combined Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Pre-school Children Undergoing Brain Magnetic Resonance Imaging
CTR20242820
水合氯醛栓在健康受试者中随机、开放、两制剂、单次给药、双周期、双交叉空腹状态下的生物等效性试验
IRCT20240630062282N1
Investigating the sedation effect of new chloral hydrate formulation in comparison with common formulations in children under diagnostic procedures
100 项与 水合氯醛 相关的临床结果
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100 项与 水合氯醛 相关的转化医学
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100 项与 水合氯醛 相关的专利（医药）
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4,723
项与 水合氯醛 相关的文献（医药）2025-09-01TALANTA
Isotope-coded hydrazide tags for MALDI-MS based quantitative glycomics
Article
作者: Liu, Xin ; Hu, Zhaoyu ; Fei, Jian ; Liu, Si ; Du, Wei ; Sha, Qiuyue ; Di, Chao
The detection of glycosylation alterations is essential for elucidating the roles of glycan functions in biological processes and identifying potential disease biomarkers. Stable isotopic chemical labeling, coupled with mass spectrometry (MS), represents a powerful approach in quantitative glycomics. In this study, we synthesized a novel isotopic hydrazide pair, 2,6-Dimethyl-4-chinolincarbohydrazid (DMQCH) and its deuterium isomer DMQCH-d4, via an efficient and cost-effective method, and applied it for the first time in MALDI-MS-based quantitative glycomics. The hydrazide tags, DMQCH/DMQCH-d4, enabled stable mass shifts through reductive-terminal reactions with glycans, allowing for differential mass tagging of two samples without additional purification after derivatization. This DMQCH/DMQCH-d4 pair exhibited high derivatization efficiency (including on-target derivatization), substantial improvements in MS signal intensity (a 15-fold increase for maltoheptaose, high reproducibility (CV < 13.6 %), and excellent linearity (R2 > 0.99) over two orders of magnitude in dynamic range for the relative quantitative analysis of maltoheptaose. Furthermore, this isotopic hydrazide pair was validated by successfully measuring changes in serum N-glycan profiles from individuals with healthy human serum control and ovarian cancer, highlighting its potential in quantitative glycomics for clinical applications.
2025-08-01DESALINATION
Tracing disinfection byproducts during shock chlorination of a seawater reverse osmosis (RO) desalination pilot and the blended and chlorinated potable water produced
作者: Le, Thi Xuan Hoa ; Shang, Chii ; Xiang, Yingying ; Wang, Kun ; Lin, Chuanjing
Shock chlorination is an increasingly recognized strategy applied in seawater reverse osmosis (RO) desalination plants to mitigate membrane fouling.The obtained desalinated seawater is often blended with treated drinking water and subsequently chlorinated for domestic use.This study traced the formation of disinfection byproducts (DBPs) and the associated cytotoxicity during shock chlorination of a pilot seawater RO desalination system and the subsequent chlorination of the blended water at different blending ratios.Brominated DBPs (Br-DBPs) including tribromomethane, tribromoacetic acid, and dibromoacetic acid dominated right after shock chlorination.The dissolved air flotation combined with the sand filtration partially removed DBPs, possibly through volatilization, adsorption, biodegradation, and transformation of DBPs.The rejection rate of Br-DBPs was significantly higher than that of chlorinated DBPs, leading to the overall high RO rejection rate of trihalomethanes (THMs) (98.92 %), haloacetic acids (HAAs) (99.01 %), and haloacetonitriles (HANs) (94.47 %).In the chlorinated blended water, the total concentration of DBPs decreased while the fraction of Br-DBPs increased with increasing ratio of desalinated seawater, peaking at a blending ratio of 20 % of desalinated seawater.This is due to the dilution of DBPs and DBP precursors (i.e., natural organic matter) originated in treated drinking water by the desalinated seawater, which however increased Br- concentrations in the blended water.Brominated HANs and brominated HAAs were the main contributors to DBP-associated cytotoxicity.The blending ratio of 60 % or higher of desalinated seawater is suggested to minimize DBP concentration and cytotoxicity in the chlorinated blended water.The findings of this study enhance our understanding of the behavior of DBPs and their associated cytotoxicity during shock chlorination in seawater RO desalination plants and in chlorinated blended water, providing a theor. basis for real-world application.
2025-06-01BRAIN & DEVELOPMENT
Risk factors for sedation and MRI failure in children with neurodevelopmental disorders undergoing head MRI with oral triclofos sodium and/or rectal chloral hydrate
Article
作者: Mimaki, Nobuyoshi ; Itami, Keisuke ; Matsuda, Natsuko ; Zensho, Kazumasa ; Akaike, Hiroto ; Tokumasu, Hironobu ; Kubota, Masamichi ; Asakawa, Toru
BACKGROUND:
Head magnetic resonance imaging (MRI) is of critical importance in the diagnosis and management of neurodevelopmental disorders. However, the use of sedation in affected children can present a significant challenge.
AIMS:
To identify the factors associated with sedation and MRI failure in children with neurodevelopmental disorders undergoing head MRI with oral triclofos sodium or rectal chloral hydrate.
METHODS:
This retrospective study analyzed 215 MRI sessions of children with neurodevelopmental disorders from January 2020 to December 2021. Sedation was administered via oral triclofos sodium or rectal chloral hydrate. Multivariate logistic regression was used to determine the factors associated with sedation failure and MRI failure.
RESULTS:
The sedation failure rate was 38.1 % (82/215). Factors significantly associated with sedation failure were older age (odds ratio [OR] 1.59, 95 % confidence interval [CI] 1.30-1.95, p < 0.001) and stranger anxiety (OR 4.07, 95 % CI 1.95-8.49, p < 0.001). The age cut-off for increased sedation failure risk was 4.0 years (p < 0.01). The MRI failure rate was 21.9 % (47/215), associated with autism spectrum disorder (ASD) diagnosis (OR 19.00, 95 % CI 2.43-149.00, p < 0.01), stranger anxiety (OR 3.66, 95 % CI 1.62-8.24, p < 0.01), and place anxiety (OR 3.18, 95 % CI 1.33-7.57, p < 0.01).
CONCLUSIONS:
Older age and stranger anxiety are significant risk factors for sedation failure, while ASD diagnosis, stranger anxiety, and place anxiety increase MRI failure risk in children with neurodevelopmental disorders undergoing head MRI.
100 项与 水合氯醛 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 镇静 | 中国 | 2019-12-30 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 158 | Second oral dose chloral hydrate 25 mg/kg | 夢構齋淵獵艱衊製鹽襯(蓋遞衊鏇網齋淵夢積餘) = 壓鏇鬱鹽願壓製選壓繭 獵鑰廠窪壓願壓願糧窪 (壓構獵鏇製憲憲鬱壓觸 ) | - | 2016-03-01 | ||
Intranasal dexmedetomidine 1 mcg/kg | 夢構齋淵獵艱衊製鹽襯(蓋遞衊鏇網齋淵夢積餘) = 築簾蓋糧憲積鹽鹽製鏇 獵鑰廠窪壓願壓願糧窪 (壓構獵鏇製憲憲鬱壓觸 ) | ||||||
临床4期 | 90 | Placebo+Dexmedetomidine (Oral Placebo and Intransal Dexmedetomidine) | 餘構糧顧願鏇夢糧壓淵(獵齋壓繭繭淵衊遞壓醖) = 構齋齋齋膚簾憲鹹願積 積鏇鹽鹽淵鹽網獵願積 (構憲夢壓鏇鹽蓋廠餘築, 衊網鹽繭艱衊築廠淵鏇 ~ 遞選選衊範齋齋餘積襯) 更多 | - | 2016-02-22 | ||
Placebo+Chloral Hydrate (Oral Chloral Hydrate and Intranasal Placebo) | 餘構糧顧願鏇夢糧壓淵(獵齋壓繭繭淵衊遞壓醖) = 觸網夢憲選襯獵醖艱窪 積鏇鹽鹽淵鹽網獵願積 (構憲夢壓鏇鹽蓋廠餘築, 齋鹽遞鏇獵範衊網衊憲 ~ 鬱築襯顧繭積膚範繭鏇) 更多 | ||||||
N/A | - | 216 | 製窪糧簾築築觸網醖窪(醖壓衊淵衊壓壓鏇簾憲) = 範憲襯築窪淵壓網衊齋 齋鹹憲夢齋廠築築襯遞 (顧餘獵醖鹽襯齋壓襯夢 ) | - | 2010-02-01 | ||
製窪糧簾築築觸網醖窪(醖壓衊淵衊壓壓鏇簾憲) = 鹹選鏇製遞醖蓋夢蓋簾 齋鹹憲夢齋廠築築襯遞 (顧餘獵醖鹽襯齋壓襯夢 ) | |||||||
N/A | 18 | 網膚範醖鬱廠衊鹹夢繭(鑰艱廠鹽鏇鏇願齋襯顧) = 積繭築選範鹽憲範糧餘 膚簾襯觸築簾糧蓋夢獵 (襯廠獵醖衊網範築顧構, 30 ~ 150) 更多 | - | 2003-05-01 | |||
醖襯衊鑰糧憲網憲範衊(廠鏇蓋製窪積膚醖鬱顧) = 餘艱顧選願鹹醖願觸艱 製壓壓鹽網選簾積願獵 (餘製選廠遞簾憲窪構製 ) |
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