The dynamics of the metastatic prostate cancer market are anticipated to change in the coming years owing to the rise in the number of companies taking interest in the development of specific drugs for mCRPC and nmCRPC along with increasing awareness and penetration of already approved prostate cancer drugs.
LAS VEGAS, Dec. 13, 2023 /PRNewswire/ -- DelveInsight's
Metastatic Prostate Cancer Market Insights report includes a comprehensive understanding of current treatment practices, metastatic prostate cancer emerging drugs, market share of individual therapies, and current and forecasted market size from 2019 to 2032, segmented into 7MM [the United States, the EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan].
Key Takeaways from the Metastatic Prostate Cancer Market Report
As per DelveInsight analysis, the total market size in the 7MM for metastatic castration-resistant prostate cancer (mCRPC) was estimated to be nearly
USD 6.4 billion in 2022, which is expected to show positive growth by 2032.
In 2022, the United States held the highest market share for mCRPC and mCSPC in the 7MM, at
63% and 61%, respectively, followed by the EU4 countries and the UK.
As per DelveInsight estimates, the total prevalent population of prostate cancer in the 7MM was nearly
8 million cases in 2022. These cases will increase during the study period, i.e., 2019–2032.
Leading metastatic prostate cancer companies such as
AstraZeneca, Merck Sharp & Dohme, Hinova Pharmaceuticals, Pfizer, Astellas Pharma, Modra Pharmaceuticals, AB Science, Eli Lilly and Company, Zr Pharma & GmbH, Bristol-Myers Squibb, Ipsen, Exelixis, Takeda, Janssen Research & Development, Tesaro, Lantheus Holdings, Kintor Pharmaceutical, MacroGenics, Daiichi Sankyo, Madison Vaccines, Novartis, Point Biopharma, Xencor,
Essa Pharma
, Telix International, Bayer, Arvinas, and others are developing novel metastatic prostate cancer drugs that can be available in the metastatic prostate cancer market in the coming years.
The promising metastatic prostate cancer therapies in the pipeline include
HC-1119, Talazoparib, Enzalutamide, Niraparib, Boosted Oral Docetaxel, Masitinib, EPI-7386, Verzenio, 177Lu-PSMA-617, Capivasertib, I-131-1095, Proxalutamide (GT0918), MGC018, DS-7300, MVI-816, ARV-110, 177Lu-PNT2002 (PNT2002), Vudalimab (XmAb20717), 177Lu-DOTA-rosopatamab (TLX591), and others.
Established therapies in the metastatic prostate cancer market include Astella/Pfizer's and Jansenn's blockbuster products XTANDI and ZYTIGA, respectively, approved for metastatic patients for over a decade now. Even though
ZYTIGA's generics have entered the US market since 2019, and the EU since late 2022, leading to a drastic decline in the revenue mainly in the US, the product is extensively being evaluated in combination with novel emerging therapies, leading to an increase in patient share on the compound abiraterone acetate. Whereas,
Jansenn's XTANDI, the biggest revenue generator in the prostate cancer market, has witnessed stable growth since 2021 owing to increased competition.
Quantitatively mCRPC pipeline seems to be quite strong, however with recent failures/terminations of several trials of certain therapies in the past year, we have mentioned the most promising ones, which include
ESSA Pharma's EPI-7386, Macrogenics, and Daiichi's anti-B7-H3 Antibody Drug Conjugates, MGC-018 and DS-7300 respectively, Arvinas, AR-targeted PROTAC protein degrader, and Point Biopharma's Radioligand therapy. Except for Point Biopharma's therapy, none of these potential players have initiated a Phase III trial, even though Arvinas is planning to opt for an accelerated approval based on its Phase II data readout.
The landscape of mHSPC has evolved tremendously in the past decades. The treatment paradigm has shifted from androgen deprivation therapy (ADT) alone to doublet combinations comprising ADT with docetaxel or an androgen receptor inhibitor, and now triplet therapy involving all three classes of agents.
Apart from
XTANDI, ZYTIGA, and ERLEADA in the mCSPC market,
Bayer's NUBEQA is another rising contender with a strong uptake in a short period. Bayer is further strategizing to increase the prescription by volume for NUBEQA by label expansion in patients who are not eligible for chemotherapy in the ARANOTE Phase III trial.
PARP inhibitors such as
AKEEGA and TALZENNA are also currently being evaluated in the mHSPC space alone and with ARIs.
Novartis' radioligand therapy,
PLUVICTO approved in 2022, has generated an unexpected revenue from the third-line mCRPC setting, further plans to expand in an earlier line in mCRPC by 2024 in the United States. The approval of PLUVICTO has also marked a crucial advancement in treating progressive mCRPC, offering improved survival rates for those with limited treatment options.
The drug had an exceptionally robust initial market performance, garnering a stronger-than-expected uptake in the US. The drug is currently being studied in the Phase III PSMAddition study to see if that triplet combination is better than ADT and an androgen receptor signaling inhibitor alone in patients with mHSPC.
Discover which therapies are expected to grab the major metastatic prostate cancer market share @
Metastatic Prostate Cancer Market Report
Metastatic Prostate Cancer Overview
Prostate cancer, a form of malignancy specific to the prostate gland within the male reproductive system, can advance to a metastatic stage, spreading from the prostate to other areas of the body. This advanced stage is often referred to as metastatic or advanced prostate cancer, commonly extending to lymph nodes or bones. Prostate cancer symptoms can differ widely among individuals. Although some men might not experience any symptoms, typical signs may include the presence of blood in the urine or semen, painful ejaculation, discomfort or a burning sensation during urination, and various other related symptoms. The primary diagnostic method involves prostate-specific antigen (PSA) testing, which detects elevated PSA levels in individuals affected by prostate cancer or other prostate-related conditions. Screening processes may also include a digital rectal exam to identify any notable prostate tumors, alongside additional methods such as prostate ultrasound and MRI scans. However, a conclusive diagnosis typically necessitates a transrectal ultrasound-guided (TRUS) prostate tissue biopsy.
Metastatic Prostate Cancer Epidemiology Segmentation
As per DelveInsight analysis, the United States had the highest number of diagnosed prostate cancer cases in 2022, with approximately
2.9 million reported cases.
In 2022, total cases of metastatic CSPC/HSPC and metastatic CRPC were around
100K and
120K, respectively, in the 7MM. These cases are expected to increase by 2032.
The metastatic prostate cancer market report proffers epidemiological analysis for the study period 2019–2032 in the 7MM segmented into:
Total Prevalent Cases of Prostate Cancer
Total Diagnosed Cases of Prostate Cancer
Age-Specific Cases of Prostate Cancer
Total Diagnosed Cases of Prostate Cancer by Clinical Stages
Total Metastatic Cases of Prostate Cancer
Total Treated Cases of mCRPC
Total Treated Cases of mCSPC
Metastatic Prostate Cancer Treatment Market
Metastatic Castration-Resistant Prostate Cancer (mCRPC) is a stage of prostate cancer that has spread to other parts of the body, such as lymph nodes or bones, and no longer responds to treatment that lowers testosterone. Despite currently approved therapeutics, mCRPC remains a terminal diagnosis with an aggressive disease course. ADT is a stalwart therapy for the initial treatment of metastatic disease. Unfortunately, most men in this situation will go on to develop mCRPC and require secondary systemic therapy. This disease state can be very challenging to treat.
Docetaxel was the only agent available for the treatment of mCRPC until 2010, which showed an increase in overall survival compared with the standard of care. It was approved in 2004 for mCRPC with prednisone. Patients failed to first-line docetaxel for many years, and no standard treatment option was approved. However, in the last few years, several drugs such as
JEVTANA, ZYTIGA, XTANDI, LYNPARZA, TALZENNA, AKEEGA, and others have received regulatory approval for mCRPC in the United States.
Most recently, PARP inhibitors have shown tremendous development in this area with AKEEGA (Janssen), followed by TALZENNA (Pfizer/Astellas Pharma) and LYNPARZA in combination (AstraZeneca/Merck) getting approved in mCRPC in 2023.
The approval of
PLUVICTO has also marked a crucial advancement in treating progressive mCRPC, offering improved survival rates for those with limited treatment options.
The drug had an exceptionally robust initial market performance, garnering a stronger-than-expected uptake in the US.
Quantitatively, the mCRPC pipeline seems to be quite strong. ADCs such as MGC018 and DS-7300 have both displayed encouraging results in clinical trials involving patients with mCRPC. However, except for Point Biopharma's therapy, none of these potential players have initiated a Phase III trial, even though Arvinas plans to opt for an accelerated approval based on its Phase II data readout.
Metastatic Castrate-Sensitive Prostate Cancer (mCSPC) is an advanced form of cancer in which cancer cells have spread from the prostate to other body areas. However, the patient is still sensitive to androgen deprivation therapy (ADT) (some mCSPC patients have never had ADT, while others may have had ADT but have recovered testicular function).
The backbone of all treatments in mCSPC is
androgen deprivation therapy (ADT) with medications that suppress the level of testosterone in the body because testosterone is the fuel for prostate cancer and gives the signals to grow and spread. Studies over the last decade have demonstrated that intensification of androgen deprivation with different treatment modalities correlates with prolongation of survival. The options for intensification include
docetaxel chemotherapy, different
androgen receptor-targeted agents, including
abiraterone acetate,
apalutamide, and
enzalutamide, and
radiation to the prostate. Most recently, the treatment paradigm for mHSPC shifted to triplet therapy,
NUBEQA
combined with ADT and chemotherapy. According to the findings presented at the ASCO GU 2023, the regimen should be considered the new standard of care for this patient population.
To know more about metastatic prostate cancer treatment guidelines, visit @
Metastatic Prostate Cancer Management
Metastatic Prostate Cancer Pipeline Therapies and Key Companies
Capivasertib (AZD 5363): AstraZeneca
Bavdegalutamide (ARV-110): Arvinas
MVI-816 (pTVG-HP): Madison Vaccines
PT-112: Phosplatin Therapeutics
HC-1119: Hinova Pharmaceuticals
OPDIVO (nivolumab): Bristol Myers Squibb
KEYTRUDA (Pembrolizumab/MK-3475): Merck
MGC018 (vobramitamab duocarmazine): MacroGenics
DS-7300: Daiichi Sankyo
Ceralasertib: AstraZeneca
Ladiratuzumab vedotin: Seagen/Merck
BMS-986218: Bristol-Myers Squibb
TAS-115: Taiho Pharmaceutical
ModraDoc006/r: Modra Pharmaceuticals
Vudalimab: Xencor
(Lu-177) - PNT2002: Point Biopharma
LNTH-1095 (MIP-1095): Lantheus Holdings
ZEN-3694: Zenith Epigenetics
EPI-7386: Essa Pharma
177Lu-DOTA-rosopatamab: Telix Pharmaceuticals
Proxalutamide: Kintor Pharmaceutical
Masitinib: AB Science
VERZENIO (Abemaciclib/LY2835219): Eli Lilly and Company
CABOMETYX (cabozantinib): Exelixis
Learn more about the FDA-approved drugs for metastatic prostate cancer @
Drugs for Metastatic Prostate Cancer Treatment
Metastatic Prostate Cancer Market Dynamics
The dynamics of the metastatic prostate cancer are expected to change in the coming years. Before 2010,
docetaxel was the primary therapeutic option for metastatic castration-resistant prostate cancer (mCRPC), demonstrating improved overall survival compared to the established standard of care. Its approval in 2004, alongside prednisone, marked a
milestone in mCRPC treatment. Following initial docetaxel therapy failure, patients faced a dearth of approved second-line treatments for numerous years. However, recent years have witnessed regulatory approvals of multiple drugs in the United States for mCRPC, transforming the treatment landscape.
Notably, medications such as
JEVTANA, ZYTIGA, XTANDI, LYNPARZA, TALZENNA, AKEEGA, and several others have gained approval. Of late, significant advancements have emerged in the realm of mCRPC, particularly with PARP inhibitors.
AKEEGA from Janssen, TALZENNA jointly developed by
Pfizer and Astellas Pharma, and the combination of
LYNPARZA by AstraZeneca and Merck garnered approval in 2023, showcasing remarkable progress in this domain.
PLUVICTO's approval is a significant leap forward in the management of progressive metastatic castration-resistant prostate cancer, bringing
improved survival rates to patients with limited treatment alternatives. The drug witnessed an exceptional and robust initial performance in the US market, exceeding expectations.
In numerical terms, the pipeline for metastatic castration-resistant prostate cancer appears robust. Antibody-drug conjugates like
MGC018 and DS-7300 have demonstrated promising outcomes in clinical trials among mCRPC patients. Nevertheless, except for
Point Biopharma's treatment, the majority of these prospective treatments have yet to commence a Phase III trial. Despite this,
Arvinas intends to pursue an expedited approval pathway leveraging its Phase II data for regulatory approval.
Scope of the
Metastatic Prostate Cancer
Market Report
Therapeutic Assessment: Metastatic Prostate Cancer current marketed and emerging therapies
Metastatic Prostate Cancer
Market Dynamics: Key Market Forecast Assumptions of Emerging Metastatic Prostate Cancer Drugs and Market Outlook
Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
Unmet Needs, KOL's views, Analyst's views, Metastatic Prostate Cancer Market Access and Reimbursement
Discover more about metastatic prostate cancer drugs in development @
Metastatic Prostate Cancer Clinical Trials
Table of Contents
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