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更新于：2025-04-17
Gatifloxacin
加替沙星
更新于：2025-04-17
概要
基本信息
药物类型 小分子化药 |
别名 1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid、Bonoq、Bonoq Uro + [99] |
作用方式 抑制剂 |
作用机制 Bacterial DNA gyrase 抑制剂(细菌DNA旋转酶 抑制剂)、Bacterial top IV抑制剂(细菌拓扑异构酶IV抑制剂) |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C38H50F2N6O11 |
InChIKeyRMJMZKDEVNTXHE-UHFFFAOYSA-N |
CAS号180200-66-2 |
关联
37
项与 加替沙星 相关的临床试验NCT03578276
Lessdrops™ Prophylactic Treatment After Routine Phacoemulsification Compared to Standard Drops Regimen
CTRI/2015/05/005781
Evaluation of efficacy of gatifloxacin (0.3%) in the treatment of non-perforated bacterial corneal ulcers
CTR20150066
加替沙星治疗化脓性中耳炎、中耳胆脂瘤和外耳道炎随机、单盲、阳性药平行对照并剂量探索、多中心Ⅱ期试验
100 项与 加替沙星 相关的临床结果
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100 项与 加替沙星 相关的转化医学
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100 项与 加替沙星 相关的专利（医药）
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4,892
项与 加替沙星 相关的文献（医药）2025-07-01SEPARATION AND PURIFICATION TECHNOLOGY
Synergistic doped and loaded strategies to modify WO3 nanoflowers for efficient photocatalytic degradation of antibiotics through reactive oxygen species regulation
作者: Li, Xiuze ; Liu, Wen ; Yang, Xudong ; Qi, Juanjuan ; Guo, Liangyan
Developing an effective and powerful photocatalyst is important to its practical application in water treatment area, like emerging contaminants removal in water.Herein, through a synergistic strategy of N-doping and carbon quantum dots (CQDs)-loading on WO3 nanoflowers, CQDs/N-WO3 was designed, which exhibited excellent photocatalytic performance due to modulated electronic structure.Both exptl. characterization and theor. calculation confirmed that the synergistic effect accelerated the electron transfer ability from O2p to W5d, thus promoting the photogenerated electron and hole separation efficiency owing to the increased W5d orbital electron d.The optimum photocatalyst achieved 100 % removal of gatifloxacin (GAT) with a high reaction rate constant (k1) of 0.055 min-1 in 60 min under simulated solar light.Moreover, quenching experiment and radical detection demonstrated that the main reactive oxygen species (ROS) changed from •OH (WO3 and N-WO3) to O•-2 (CQDs/N-WO3) for GAT removal.D. functional theory (DFT) calculation based on Fukui index further indicated the reactive sites of GAT were available for electrophilic attack.The internal mechanism was also deduced that after N doped and CQDs loaded on WO3, narrowed band gap and increased utilization of visible light were observedMoreover, the high electron d. of N sites was more conducive to hole capture, and CQDs enhanced the electron transport as electron acceptor and transporter.The synergistic strategy of doping and loading opens a new perspective for modulating the electronic structure of catalysts, and provides a reference for regulating the ROS types in Fenton-like reactions for the removal of emerging contaminants in water.
2025-06-01BIOORGANIC CHEMISTRY
Green synthesis of selenium nanoparticles, and its conjugation with antibacterial proteins for enhancing their antibacterial activity
Article
作者: Alotaibi, Khalid S ; Shindia, Ahmed ; Gaber, Ahmed ; Mourad, Amany N ; El-Saber, Mahmoud M ; Soliman, Mohamed Mohamed ; Alsharif, Abdualziz ; Elariny, Eman Y T ; Osman, Ali
This study aimed to determine the frequency of multi-drug-resistant bacteria (MDR) found in patients with urinary tract infections (UTIs) and to analyze the antibiotic resistance patterns in these patients. Additionally, Selenium nanoparticles (Se-NPs) were synthesized using eco-friendly methods and conjugated with antibacterial proteins (7S and 11S globulins) from red kidney beans to enhance their antibacterial properties. The highest percentages of resistance were found for Amikacin (AK; 43 %), Cefuroxime (CXM; 42 %), Gatifloxacin (GAT; 38 %), Clindamycin (DA; 38 %), Ciprofloxacin (CIP; 36 %), Ceftriaxone (CRO; 35 %), Cefoperazone/Sulbactam (CES; 34 %), Nitrofurantoin (F; 31 %), Piperacillin (PRL; 26 %), and Amoxicillin/Clavulanic acid (AMC; 23 %). The 10 bacterial isolates resistant to more than or equal to 80 % of selected antibiotics were chosen and then identified. All ten isolates were confirmed to be Acinetobacter spp., Klebsiella pneumoniae, and E. coli. The synthesis of Se-NPs was indicated by colour changes to ruby red and are preliminary substantiated by UV-Vis spectrum high peak absorption spectrum at 388 nm for Se-NPs, while the conjugated Se-NPs with 7S protein were 400 nm as well as Se-NPs with 11S protein were 420 nm. The TEM and DLS confirmed the formation of selenium nanoparticles of several sizes. Results showed that 11S globulin had the highest antibacterial activity of 7S globulin and isolated protein, recording the MIC at 125 μg/mL. Conjugation between Se-NPs with antibacterial proteins (protein isolates, 7S, and 11S) has MBC (125 μg/mL) and MIC (125 μg/mL) values against tested bacteria.
2025-06-01FUEL
From electric field accelerated generation of SO4-·/·OH radicals to rapid mineralization of gatifloxacin: The role of Fe@Fe-UP@NCA activated persulfate induced free radicals
作者: Chen, Dandan ; Zhu, Xuejun ; Hu, Yan ; Wu, Fenghui ; Ren, Nanqi ; Ren, Yuanchuan ; Niu, Qiang
The performance of Fe@Fe-UP@NCA catalyst for electro assisted degradation of gatifloxacin (GAT) in salt containing wastewater was studied.In order to achieve higher degradation efficiency of three dimensional electrochem. reactor (3DER), based on previous research, the Fe@Fe-UP@NCA/3DER system was assembled using high sp. surface area Fe@Fe-UP@NCA particles as particle electrodes, and the influence of operating parameters on the catalytic degradation of organic pollutants such as GAT was studied.Under the optimal process parameters, after 6 min of reaction, the removal rates of GAT, COD, and TOC obtained were 81.39 %, 71.74 %, and 55.65 %, resp.The concentration change of GAT conforms to the quasi first order kinetic equation, with a kinetic constant of 0.0887 min-1 and an energy consumption of only 71.09 kWh/kg GAT.During the catalyst regeneration cycle, it was found that after 6 cycles of degradation of GAT wastewater, the GAT removal rate only decreased by 0.26 %.In addition, XRD, SEM-EDS, FT-IR, Raman and XPS characterization showed that the rich pore structure, high sp. surface area, and abundant surface multi metal atom catalytic active sites enable peroxymonosulfate (PMS) mols. to be affected by the rich and poor electron centers on the NCA surface, decomposing to produce active components with strong catalytic oxidation performance, such as .OH and SO-4., which can achieve the fracture and mineralization of organic pollutants in a short period of time.This can be confirmed by ESR (EPR) spectroscopy.Due to the fact that the N4-Fe-O-Fe-N4 coordination (four coordination unit) center was the essential structure of Fe@Fe-UP@NCA surface metal atoms, and the unsaturated Fe coordination content was high, the degree of ligand defects was large, and the metal atoms have a higher d., thus exhibiting excellent catalytic performance.Further inference of the degradation mechanism and pathway of GAT was made through liquid chromatog.-mass spectrometry (LC-MS) assistance: under elec. field enhancement, electron migration and valence state conversion between metal ions promote PMS activation and the rapid occurrence of Fenton-like reaction, forming .OH and SO-4. that continuously attack GAT.By replacing or removing oxygen-containing functional groups, the GAT structure was broken, generating many intermediate products, and ultimately fully mineralized into inorganic substances such as CO2, H2O, NO-3 and F-.This study provides new tech. support for activating PMS to degrade organic pollutants in saline wastewater using easily recyclable catalysts.
100 项与 加替沙星 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 睑缘炎 | 日本 | 2004-09-07 | |
| 结膜炎 | 日本 | 2004-09-07 | |
| 角膜溃疡 | 日本 | 2004-09-07 | |
| 泪囊炎 | 日本 | 2004-09-07 | |
| 睑腺炎 | 日本 | 2004-09-07 | |
| 细菌性结膜炎 | 美国 | 2003-03-28 | |
| 感染 | 中国 | 2002-10-29 | |
| 急性细菌性支气管炎 | 美国 | 1999-12-17 | |
| 急性鼻窦炎 | 美国 | 1999-12-17 | |
| 慢性支气管炎 | 美国 | 1999-12-17 | |
| 社区获得性肺炎 | 美国 | 1999-12-17 | |
| 淋病 | 美国 | 1999-12-17 | |
| 肾盂肾炎 | 美国 | 1999-12-17 | |
| 泌尿道感染 | 美国 | 1999-12-17 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 中耳炎 | 临床3期 | 美国 | - | |
| 中耳胆脂瘤 | 临床2期 | 中国 | - | 2013-10-08 |
| 外耳炎 | 临床2期 | 中国 | - | 2013-10-08 |
| 化脓性中耳炎 | 临床2期 | 中国 | - | 2013-10-08 |
| 细菌性角膜炎 | 临床2期 | 美国 | 2003-10-01 | |
| 细菌性角膜炎 | 临床2期 | 印度 | 2003-10-01 | |
| 炎症 | 临床1期 | - | - | 2013-10-08 |
| 炭疽 | 临床前 | 美国 | - |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 35 | (LessDrops) | 餘鑰襯衊製鹽糧鏇積衊(襯鏇淵憲鏇繭積繭壓淵) = 夢蓋鹽憲鬱積淵齋壓糧 齋齋願襯鹽憲廠鹽顧構 (願艱構夢淵遞襯壓構膚, 8.46) 更多 | - | 2022-06-10 | ||
餘鑰襯衊製鹽糧鏇積衊(襯鏇淵憲鏇繭積繭壓淵) = 廠襯願製願積鏇夢廠艱 齋齋願襯鹽憲廠鹽顧構 (願艱構夢淵遞襯壓構膚, 4.13) 更多 | |||||||
临床3期 | - | (Standard 6-month treatment) | 遞構鬱鹽網膚築願艱夢(願選顧顧夢窪艱艱衊廠) = 膚簾網積艱壓積夢願膚 築築遞襯廠積醖衊憲鏇 (鹹願艱淵遞膚衊膚網範 ) 更多 | - | 2017-07-01 | ||
Test regimen with gatifloxacin, rifampin, and isoniazid | 遞構鬱鹽網膚築願艱夢(願選顧顧夢窪艱艱衊廠) = 壓齋製鏇夢獵衊蓋窪鏇 築築遞襯廠積醖衊憲鏇 (鹹願艱淵遞膚衊膚網範 ) 更多 | ||||||
N/A | - | 繭簾鏇簾繭蓋繭壓餘簾(齋鹽願繭鬱餘餘憲艱餘) = 選觸艱艱鏇繭膚鹽簾鬱 餘醖艱鹽選鹽鏇夢鹹鏇 (鹹壓繭憲鬱窪願齋窪夢, 0.02) | - | 2015-11-15 | |||
Polymyxin-trimethoprim | 繭簾鏇簾繭蓋繭壓餘簾(齋鹽願繭鬱餘餘憲艱餘) = 繭範膚襯願齋齋繭淵夢 餘醖艱鹽選鹽鏇夢鹹鏇 (鹹壓繭憲鬱窪願齋窪夢, 0.02) | ||||||
N/A | - | - | 衊衊選簾獵憲夢糧蓋淵(觸蓋鑰鏇築蓋觸襯構選) = 壓顧餘淵鏇鏇簾網繭糧 繭壓壓艱鹽製壓簾齋願 (壓繭淵衊選範積願夢糧 ) | - | 2015-06-01 | ||
临床4期 | 60 | 衊獵鏇鬱壓餘鬱憲淵衊 = 築鬱淵衊遞廠鑰選醖醖 糧網壓窪範醖鹹襯網夢 (積簾餘鑰糧願構糧艱構, 簾淵夢獵繭餘蓋醖願選 ~ 蓋淵蓋獵網淵網蓋網構) 更多 | - | 2015-01-29 | |||
临床3期 | 1,437 | 鑰遞網襯糧壓醖選蓋憲(選範壓醖鹹醖襯壓醖獵) = AEs were reported by 11.6% and 13.3% of patients in the gatifloxacin 0.5% and vehicle safety populations, respectively 積鹽築製鏇願衊窪壓網 (醖餘憲遞選鹽範鹽餘鬱 ) 更多 | - | 2014-12-01 | |||
Vehicle | |||||||
临床3期 | 1,836 | 4-month gatifloxacin-containing regimen | 廠願積築製鏇觸齋遞醖(積製鹽顧齋顧獵夢窪餘) = 構選蓋顧鹹蓋憲願窪簾 構觸簾鹹衊鬱觸觸簾襯 (廠獵觸築齋餘鏇觸鬱壓 ) 更多 | 不佳 | 2014-10-23 | ||
standard regimen | 廠願積築製鏇觸齋遞醖(積製鹽顧齋顧獵夢窪餘) = 遞繭醖鬱膚窪窪選憲衊 構觸簾鹹衊鬱觸觸簾襯 (廠獵觸築齋餘鏇觸鬱壓 ) 更多 | ||||||
临床4期 | - | 129 | 選築齋鹽積廠願憲鑰膚 = 衊遞壓廠襯壓壓醖齋遞 壓衊獵鬱餘鑰積窪衊糧 (廠齋顧鏇鹹選艱鹽鹽壓, 範憲構憲壓範齋網鹹範 ~ 網齋觸鹹餘願衊夢窪艱) 更多 | - | 2014-06-12 | ||
临床3期 | 169 | 製膚鹹餘觸憲築鬱鹽選(觸鏇鏇壓蓋範鑰蓋獵壓) = 築鹽壓製齋獵齋淵遞顧 鹽獵顧鹹觸簾網網觸鑰 (製製積襯鑰齋築鹽蓋艱, -90.5% ~ +61.5%) | - | 2013-09-01 | |||
N/A | 627 | 膚醖範範遞遞夢鏇糧願(願網網鑰淵範衊餘繭餘): HR = 0.81 (95% CI, 0.25 ~ 2.65), P-Value = 0.73 更多 | 不佳 | 2013-01-01 | |||
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