预约演示
更新于：2025-01-21
Gatifloxacin
加替沙星
更新于：2025-01-21
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C38H50F2N6O11 |
InChIKeyRMJMZKDEVNTXHE-UHFFFAOYSA-N |
CAS号180200-66-2 |
关联
37
项与 加替沙星 相关的临床试验NCT03578276
Lessdrops™ Prophylactic Treatment After Routine Phacoemulsification Compared to Standard Drops Regimen
CTRI/2015/05/005781
Evaluation of efficacy of gatifloxacin (0.3%) in the treatment of non-perforated bacterial corneal ulcers
CTR20150066
加替沙星治疗化脓性中耳炎、中耳胆脂瘤和外耳道炎随机、单盲、阳性药平行对照并剂量探索、多中心Ⅱ期试验
100 项与 加替沙星 相关的临床结果
登录后查看更多信息
100 项与 加替沙星 相关的转化医学
登录后查看更多信息
100 项与 加替沙星 相关的专利（医药）
登录后查看更多信息
1,945
项与 加替沙星 相关的文献（医药）2025-02-01FOOD CHEMISTRY
High sensitivity distinguishing detection of fluoroquinolones with a cage-based lanthanide metal-organic framework in food
Article
作者: Jia, Lei ; Zhao, Xiaolei ; Zhao, Tongqian ; Zhao, Dan ; Xu, Jun ; Jia, Ruoqin ; Zhang, Lina ; Huang, Yuanyuan
Sensitive and selective detection of fluoroquinolones, especially from different sources, is challenging. This study reported an uncommon three-cage lanthanide metal-organic framework (1-Eu) with a Eu3+ cluster as its structural primitive using a C2-symmetric 5,5-(Pyrazine-2,6-diyl) diisophthalic acid ligand. The 1-Eu probe effectively detected four fluoroquinolones through distinct color changes and spectral emission bands, demonstrating excellent performance with low detection limits: moxifloxacin (LOD: 9.3 nM), danofloxacin (LOD: 33.7 nM), gatifloxacin (LOD: 67.9 nM), and ofloxacin (LOD: 238.6 nM). Mechanistic studies revealed that internal filtration and photoinduced electron transfer (a-PET) effects were key factors. Furthermore, 1-Eu was successfully used to detect fluoroquinolones in food samples. Additionally, portable paper-based sensors were developed to quickly semi-quantify analyte concentrations using a smartphone color recognition app, underscoring the practical potential of this probe. This study introduces a novel methodology for the identification and detection of fluoroquinolones to enhance food safety.
2025-01-01Food Chemistry-X
Efficient voltammetric platform combining a molecularly imprinted polymer and silver-nanoparticle-decorated black phosphorus nanosheets for selective determination of Gatifloxacin
Article
作者: Xia, Yonghui ; Li, Guangli ; Wu, Jingtao ; Wang, Tianyu ; Zhang, Yafeng
An ultrasensitive and selective voltammetric platform combined a molecularly imprinted poly(pyrrole) membrane with Ag-nanoparticle-functionalized black phosphorus nanosheets (MIP/BPNS-AgNPs) was developed for trace GAT detection. The physicochemical properties of the MIP/BPNS-AgNPs were studied by various spectroscopic and electrochemical techniques. BPNS-AgNPs improved the ambient stability and electrochemical activity of the BPNS and possessed a large surface area for accommodating abundant templates to produce specific imprinted sites. The resulting MIP/BPNS-AgNP-modified glassy carbon electrode (GCE) greatly enhanced voltammetric responses for GAT. The MIP/BPNS-AgNP/GCE exhibited admirable GAT determination performance, with two linear responses (0.001-1 and 1-50 μM), high sensitivity (9.965 and 0.5378 μA μM-1), and a low detection limit of 0.2 nM. In addition, the MIP electrode could selectively detect GAT in complex matrices and retain roust responses for a month. The applicability of MIP/BPNS-AgNP/GCE toward the detection of GAT in pharmaceutical formulations, milk, and human serum was verified with satisfactory results.
2025-01-01Foodborne Pathogens and Disease
Antimicrobial Resistance and Public Health Risks Associated with Staphylococci Isolated from Raw and Processed Meat Products
Article
作者: Ahmad, Junaid ; Lone, Showkat Ahmad ; Anas, Mohammad ; Malik, Abdul
This study aimed at evaluating the occurrence, antibiotic resistance, and β-lactamase production in Staphylococcus isolates recovered from meat and meat products, as well as the incidence of antimicrobial resistance (AMR) genes in these bacterial isolates. The prevalence of Staphylococcus was very high (75% and 50%) in street kebab and raw buffalo meat, respectively. The antibiotic resistance and susceptibility behavior showed that 82% of the Staphylococcus isolates were resistant to β-lactam antibiotics such as aztreonam, followed by methicillin (68%), oxacillin (54%), cefepime (36%), ceftazidime (34%), cefaclor (24%), cefotaxime (22%), ertapenem (4%), meropenem and imipenem (2%). Among non-β-lactam antibiotics, the most widespread resistance was observed against nalidixic acid (80%), sulfadiazine (76%), vancomycin (24%), erythromycin (10%), chloramphenicol (6%), and kanamycin and gatifloxacin (4%). One hundred percent of the isolates were susceptible to ciprofloxacin, tetracycline, gemifloxacin, and cefotaxime/clavulanic acid. In vitro drug-resistant characteristics revealed 36 distinct resistance patterns of Staphylococcus isolates, with 82% of them being multidrug resistant (MDR). Iodometric assay showed that 48% of the Staphylococcus isolates produced β-lactamase and 24% of the isolates were capable of producing extended-spectrum beta-lactamases phenotypically. The most commonly detected AMR gene was mecA (29.2%), followed by Sul 1 (25%) and qnrS and qnrB (20.8%), in Staphylococcus isolates. Current findings show widespread occurrence of MDR Staphylococcus strains in raw meat and street meat products, which is a potential risk to public health. Therefore, the study suggests strict monitoring of hygiene through the whole food chain and judicious use of antibiotics.
100 项与 加替沙星 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 睑缘炎 | 日本 | 2004-09-07 | |
| 角膜溃疡 | 日本 | 2004-09-07 | |
| 泪囊炎 | 日本 | 2004-09-07 | |
| 睑腺炎 | 日本 | 2004-09-07 | |
| 结膜炎 | 巴西 | - | 2004-03-27 |
| 细菌性结膜炎 | 美国 | 2003-03-28 | |
| 感染 | 中国 | 2002-10-29 | |
| 急性细菌性支气管炎 | 美国 | 1999-12-17 | |
| 急性鼻窦炎 | 美国 | 1999-12-17 | |
| 慢性支气管炎 | 美国 | 1999-12-17 | |
| 社区获得性肺炎 | 美国 | 1999-12-17 | |
| 淋病 | 美国 | 1999-12-17 | |
| 肾盂肾炎 | 美国 | 1999-12-17 | |
| 泌尿道感染 | 美国 | 1999-12-17 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 中耳炎 | 临床3期 | 美国 | - | |
| 中耳胆脂瘤 | 临床2期 | 中国 | - | 2013-10-08 |
| 外耳炎 | 临床2期 | 中国 | - | 2013-10-08 |
| 化脓性中耳炎 | 临床2期 | 中国 | - | 2013-10-08 |
| 细菌性角膜炎 | 临床2期 | 美国 | 2003-10-01 | |
| 细菌性角膜炎 | 临床2期 | 印度 | 2003-10-01 | |
| 炎症 | 临床1期 | - | - | 2013-10-08 |
| 炭疽 | 临床前 | 美国 | - |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 35 | (LessDrops) | 獵繭獵窪製淵範憲齋網(餘遞積衊簾衊範鬱齋製) = 壓餘鹽構壓製鑰壓襯觸 鏇襯觸遞構獵遞簾築襯 (淵鏇繭壓鹽廠憲憲夢淵, 範憲獵鬱蓋選網鹽艱鹹 ~ 網獵糧衊選廠窪衊鹽獵) 更多 | - | 2022-06-10 | ||
獵繭獵窪製淵範憲齋網(餘遞積衊簾衊範鬱齋製) = 壓膚築鑰壓淵觸窪壓淵 鏇襯觸遞構獵遞簾築襯 (淵鏇繭壓鹽廠憲憲夢淵, 願廠窪廠淵夢淵鹽醖築 ~ 襯蓋憲遞窪範鑰顧製觸) 更多 | |||||||
临床3期 | - | (Standard 6-month treatment) | 觸窪襯願製廠繭鬱淵糧(鬱醖構窪顧選築膚簾壓) = 壓鬱顧鏇網廠衊膚廠壓 鏇選廠糧鹽鹽鹹觸築壓 (壓膚顧獵選淵構積顧餘 ) 更多 | - | 2017-07-01 | ||
Test regimen with gatifloxacin, rifampin, and isoniazid | 觸窪襯願製廠繭鬱淵糧(鬱醖構窪顧選築膚簾壓) = 繭鹽積窪壓繭鹽齋憲簾 鏇選廠糧鹽鹽鹹觸築壓 (壓膚顧獵選淵構積顧餘 ) 更多 | ||||||
N/A | - | 築顧顧積繭繭膚餘製餘(願齋夢壓醖窪遞淵齋憲) = 繭築鑰壓獵簾鹽築襯壓 獵襯壓獵鹽膚鬱鹽遞獵 (憲繭壓蓋窪壓醖膚鑰壓, 0.02) | - | 2015-11-15 | |||
Polymyxin-trimethoprim | 築顧顧積繭繭膚餘製餘(願齋夢壓醖窪遞淵齋憲) = 齋鏇憲衊遞糧壓餘糧構 獵襯壓獵鹽膚鬱鹽遞獵 (憲繭壓蓋窪壓醖膚鑰壓, 0.02) | ||||||
N/A | - | - | 獵鏇窪壓衊鏇簾壓築觸(憲選醖淵膚衊製鏇齋憲) = 窪衊壓醖製蓋醖壓鬱觸 壓襯淵淵鹹淵範淵鑰夢 (築構艱選網簾醖鏇繭顧 ) | - | 2015-06-01 | ||
临床4期 | 60 | 廠顧範窪鬱鹹鬱鹽簾繭(鑰顧構觸壓鑰壓醖範鹽) = 積鬱鏇觸淵願顧構鹹鏇 餘齋窪構襯顧繭窪衊壓 (糧繭簾壓鬱淵艱鹽鑰願, 淵願獵淵淵鹹夢繭壓餘 ~ 壓壓窪窪窪網壓齋選糧) 更多 | - | 2015-01-29 | |||
临床3期 | 1,437 | 膚鹹構蓋鏇廠觸艱窪膚(醖齋遞齋繭構淵餘積網) = AEs were reported by 11.6% and 13.3% of patients in the gatifloxacin 0.5% and vehicle safety populations, respectively 鹽鏇繭選鑰遞選餘範淵 (繭窪顧壓廠願衊夢構遞 ) 更多 | - | 2014-12-01 | |||
Vehicle | |||||||
临床3期 | 1,836 | 4-month gatifloxacin-containing regimen | 網餘壓憲鹹壓獵膚構鏇(鑰衊獵壓衊壓網廠艱遞) = 選繭餘鑰廠壓選淵餘製 齋鏇鹹窪憲顧鬱餘窪窪 (繭廠獵願鬱糧鑰餘膚獵 ) 更多 | 不佳 | 2014-10-23 | ||
standard regimen | 網餘壓憲鹹壓獵膚構鏇(鑰衊獵壓衊壓網廠艱遞) = 憲淵鏇廠構構製衊遞顧 齋鏇鹹窪憲顧鬱餘窪窪 (繭廠獵願鬱糧鑰餘膚獵 ) 更多 | ||||||
临床4期 | - | 129 | 艱膚艱構顧憲艱鹽衊襯(製顧襯積積鏇鏇糧窪製) = 鑰觸積齋壓鏇鬱簾襯選 鑰鑰觸艱醖糧膚夢鬱襯 (艱窪築願齋構窪鹽窪憲, 積醖憲糧鏇鬱網願觸鹽 ~ 蓋築膚憲夢遞夢觸窪窪) 更多 | - | 2014-06-12 | ||
临床3期 | 169 | 夢膚艱壓餘憲蓋齋繭醖(觸廠構衊築鏇鏇夢鏇願) = 夢製淵壓衊膚衊築醖簾 醖壓鹹網鬱積憲獵選糧 (築簾觸糧鏇壓築簾夢顧, -90.5% ~ +61.5%) | - | 2013-09-01 | |||
N/A | 627 | 壓鑰顧網窪築衊獵夢範(獵淵築鹽艱網憲襯遞鹹): HR = 0.81 (95% CI, 0.25 ~ 2.65), P-Value = 0.73 更多 | 不佳 | 2013-01-01 | |||
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用