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Novartis AG, a Swiss-based multinational pharmaceutical company, has recently presented new 5-year data on the safety and disability outcomes of its monoclonal antibody drug, Ofatumumab, for people living with relapsing multiple sclerosis (RMS). The drug targets CD20, which is found on the surface of B-lymphocytes, and works by inhibiting CD20, leading to complement-dependent cytotoxicity (CDC) effects and antibody-dependent cellular cytotoxicity (ADCC) against B-cells.
The 5-year data presented by Novartis AG showed that patients treated earlier and continuously with Kesimpta® (ofatumumab) had fewer disability worsening events and low brain volume change versus those who started on teriflunomide and were later switched to Kesimpta. A separate analysis showed that treatment with Kesimpta for up to five years was well-tolerated, with no new or increased safety risks identified.
In conclusion, the new 5-year data presented by Novartis AG on the safety and disability outcomes of Ofatumumab for RMS patients is promising. As Novartis AG continues to focus on developing innovative drugs for a variety of therapeutic areas, Ofatumumab remains a valuable treatment option for patients living with RMS.