Apexigen America, Inc.

- Marked increases in overall survival observed across soft tissue sarcoma patients - - Demonstrated improvement of median progression free survival in patients with dedifferentiated liposarcoma (DDLPS) - - DDLPS expansion cohort enrolling to inform a potential Phase 3 registration trial - SAN CARLOS, CA, USA I June 03, 2023 I Apexigen, Inc. (Nasdaq: APGN) a clinical-stage company focused on developing innovative antibody-based therapeutics for the treatment of cancer with a focus on immuno-oncology, today announced the presentation of new data from a Phase 2 investigator-sponsored trial in collaboration with Columbia University, evaluating sotigalimab (sotiga), Apexigen’s agonist antibody targeting CD40, in combination with standard-of-care doxorubicin (dox), in patients with advanced soft tissue sarcoma (STS). These data were presented in a poster presentation on June 3, 2023 at the ASCO Annual Meeting being held both virtually and in person in Chicago, IL. Sotiga combined with dox was safe and well tolerated and indicated increases in overall survival (OS) with a median OS of 35.6 months across all STS patients evaluated, which is markedly higher than the historical OS of 12.8 to 20 months of dox alone across STS subtypes. Moreover, subtype-specific analysis demonstrated improvement in median progression-free survival (mPFS) of 10.95 months in patients with dedifferentiated liposarcoma (DDLPS) which is markedly higher than the historical mPFS of 4 months in patients with DDLPS. “We are excited to present new data at ASCO from the Phase 2 trial in patients with advanced STS that supports further development of sotiga-based combinations and underscores the significant opportunity to provide patients with meaningful clinical benefit characterized by rapid, deep and durable responses with a favorable safety profile,” said Xiaodong Yang, M.D., Ph.D., Chief Executive Officer of Apexigen. “Notably, we are encouraged by the median overall survival results across sarcoma subtypes and the data demonstrating that the subgroup of patients with DDLPS treated with sotiga in combination with dox achieved a mPFS, more than double that seen historically with dox alone. We look forward to building on these impressive findings with our DDLPS expansion cohort, which will potentially inform a Phase 3 registration study in DDLPS.” Key Takeaways: The open-label, single-arm, multicenter Phase 2 trial enrolled patients with advanced STS, including DDLPS, leiomyosarcoma (LMS), and undifferentiated pleomorphic sarcoma (UPS) and treated patients with a combination of sotiga and dox. The primary endpoint was objective response rate (ORR), and secondary endpoints were progression-free survival and safety. More information about the study is available here (NCT03719430). The abstract (#11565) is accessible on the ASCO Congress portal , and additional details are provided below. About Apexigen Apexigen is a clinical-stage biopharmaceutical company focused on discovering and developing a new generation of antibody therapeutics for oncology, with an emphasis on new immuno-oncology agents designed to harness the patient’s immune system to combat and eradicate cancer. Sotigalimab and Apexigen’s other programs were discovered using Apexigen’s proprietary APXiMAB™ discovery platform. This platform has enabled Apexigen and its collaboration partners to discover and develop therapeutic antibodies against a variety of molecular targets, including targets that are difficult to drug with conventional antibody technologies. Multiple product candidates have been discovered using the APXiMAB platform, one of which is commercially available and the others are in clinical development, either internally by Apexigen or by its licensees. For more information, please visit www.apexigen.com . SOURCE: Apexigen

- Marked increases in overall survival observed across soft tissue sarcoma patients - - Demonstrated improvement of median progression free survival in patients with dedifferentiated liposarcoma (DDLPS) - - DDLPS expansion cohort enrolling to inform a potential Phase 3 registration trial - SAN CARLOS, Calif., June 03, 2023 (GLOBE NEWSWIRE) -- Apexigen, Inc. (Nasdaq: APGN) a clinical-stage company focused on developing innovative antibody-based therapeutics for the treatment of cancer with a focus on immuno-oncology, today announced the presentation of new data from a Phase 2 investigator-sponsored trial in collaboration with Columbia University, evaluating sotigalimab (sotiga), Apexigen’s agonist antibody targeting CD40, in combination with standard-of-care doxorubicin (dox), in patients with advanced soft tissue sarcoma (STS). These data were presented in a poster presentation on June 3, 2023 at the ASCO Annual Meeting being held both virtually and in person in Chicago, IL. Sotiga combined with dox was safe and well tolerated and indicated increases in overall survival (OS) with a median OS of 35.6 months across all STS patients evaluated, which is markedly higher than the historical OS of 12.8 to 20 months of dox alone across STS subtypes. Moreover, subtype-specific analysis demonstrated improvement in median progression-free survival (mPFS) of 10.95 months in patients with dedifferentiated liposarcoma (DDLPS) which is markedly higher than the historical mPFS of 4 months in patients with DDLPS. “We are excited to present new data at ASCO from the Phase 2 trial in patients with advanced STS that supports further development of sotiga-based combinations and underscores the significant opportunity to provide patients with meaningful clinical benefit characterized by rapid, deep and durable responses with a favorable safety profile,” said Xiaodong Yang, M.D., Ph.D., Chief Executive Officer of Apexigen. “Notably, we are encouraged by the median overall survival results across sarcoma subtypes and the data demonstrating that the subgroup of patients with DDLPS treated with sotiga in combination with dox achieved a mPFS, more than double that seen historically with dox alone. We look forward to building on these impressive findings with our DDLPS expansion cohort, which will potentially inform a Phase 3 registration study in DDLPS.” Key Takeaways: The open-label, single-arm, multicenter Phase 2 trial enrolled patients with advanced STS, including DDLPS, leiomyosarcoma (LMS), and undifferentiated pleomorphic sarcoma (UPS) and treated patients with a combination of sotiga and dox. The primary endpoint was objective response rate (ORR), and secondary endpoints were progression-free survival and safety. Interim results indicated marked increases in OS across STS subtypes compared to historical standard-of-care dox monotherapy with a median OS of 35.62 months (n=32), which is remarkably higher than the historical OS of 12.8 to 20 months across STS subtypes.Subtype-specific analysis demonstrated an mPFS of 10.95 months for DDLPS patients (n=9), which is remarkably higher than the historical mPFS of 4 months for standard-of-care dox in patients with DDLPS.The interim ORR observed in the trial is comparable to the ORR of single-agent doxorubicin in the STS population. Durable objective responses and stable disease have been observed beyond what might be expected from single-agent doxorubicin.Overall, sotiga combined with dox was safe and well tolerated. Grade 3/4 treatment-related adverse events (TRAEs) occurred in 56% (18/32) of patients – the most common grade 3/4 TRAEs were neutropenia (31%), febrile neutropenia (19%), and anemia (19%) and were consistent with the safety profile of doxorubicin monotherapy.3/32 (9.4%) withdrew study treatment for AEs.Cytokine release syndrome was reported in 19% of patients – all grade 1/2.There were no additive/synergistic or unexpected AEs observed with the combination. More information about the study is available here (NCT03719430). The abstract (#11565) is accessible on the ASCO Congress portal, and additional details are provided below. Title: A phase 2 trial with a safety lead-in to evaluate the addition of sotigalimab, a CD40 agonistic monoclonal antibody, to standard-of-care doxorubicin for the treatment of advanced sarcomaFormat: Poster (Bd #499)Session Title: SarcomaSession Date and Time: Saturday, June 3 from 1:15 p.m. to 4:15 p.m. CT About Apexigen Apexigen is a clinical-stage biopharmaceutical company focused on discovering and developing a new generation of antibody therapeutics for oncology, with an emphasis on new immuno-oncology agents designed to harness the patient’s immune system to combat and eradicate cancer. Sotigalimab and Apexigen’s other programs were discovered using Apexigen’s proprietary APXiMAB™ discovery platform. This platform has enabled Apexigen and its collaboration partners to discover and develop therapeutic antibodies against a variety of molecular targets, including targets that are difficult to drug with conventional antibody technologies. Multiple product candidates have been discovered using the APXiMAB platform, one of which is commercially available and the others are in clinical development, either internally by Apexigen or by its licensees. For more information, please visit www.apexigen.com. Forward-Looking Statements This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, including statements regarding Apexigen’s ability to provide innovative oncology solutions, meet the needs of patients and provide meaningful clinical benefits; the potential attributes, uses and effectiveness of its lead candidate sotigalimab; and Apexigen’s beliefs with respect to the successful development of sotigalimab. Any statements contained herein that are not statements of historical fact may be deemed to be forward-looking statements. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. The forward-looking statements contained in this press release are based on certain assumptions and analyses made by Apexigen’s management in light of their respective experience and their perception of historical trends, current conditions and expected future developments and their potential effects on Apexigen, as well as other factors they believe are appropriate in the circumstances. There can be no assurance that future developments affecting Apexigen will be those that Apexigen has anticipated. These forward-looking statements involve a number of risks, uncertainties (some of which are beyond Apexigen’s control) or other assumptions that may cause actual results or performance to be materially different from those expressed or implied by these forward-looking statements, including Apexigen’s early stages of clinical drug development, Apexigen’s ability to achieve successful clinical results with sotigalimab, Apexigen’s competitors developing and marketing products that are more effective, safer, or less expensive than Apexigen’s product candidates, delays or difficulties in the enrollment of patients in Apexigen’s clinical trials, or that Apexigen will have sufficient capital to operate as anticipated. Should one or more of these risks or uncertainties materialize, or should any of our assumptions prove incorrect, actual results may vary in material respects from those projected in these forward-looking statements. Additional factors that could cause actual results to differ are discussed under the heading “Risk Factors” and in other sections of Apexigen’s filings with the SEC, and in its current and periodic reports filed or furnished from time to time with the SEC. All forward-looking statements in this press release are made as of the date hereof, based on information available to Apexigen and Apexigen assumes no obligation to update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws. Investor Contact:Bruce MackleLifeSci Advisors+1-646-889-1200bmackle@lifesciadvisors.com Apexigen Contact:William DukeChief Financial OfficerApexigen, Inc.+1-650-931-6236ir@apexigen.com

DUBLIN, June 2, 2023 /PRNewswire/ -- The "Global Musculoskeletal Partnering 2016-2023: Deal Trends, Players and Financials" report has been added to ResearchAndMarkets.com's offering. This report provides the full collection of musculoskeletal disease deals signed between the world's pharmaceutical and biotechnology companies since 2016. Trends in musculoskeletal partnering deals Financial deal terms for headline, upfront and royalty by stage of development Musculoskeletal partnering agreement structure Musculoskeletal partnering contract documents Top musculoskeletal deals by value Most active musculoskeletal dealmakers Most of the deals included within the report occur when a licensee obtains a right or an option right to license a licensor's product or technology. More often these days these deals tend to be multi-component including both a collaborative R&D and a commercialization of outcomes element. The report takes readers through the comprehensive musculoskeletal disease deal trends, key players and top deal values allowing the understanding of how, why and under what terms companies are currently entering musculoskeletal deals. The report presents financial deal terms values for musculoskeletal deals, where available listing by overall headline values, upfront payments, milestones and royalties enabling readers to analyse and benchmark the value of current deals. Report scope The report is intended to provide the reader with an in-depth understanding and access to musculoskeletal trends and structure of deals entered into by leading companies worldwide. Global Musculoskeletal Partnering 2016 to 2023 includes: Trends in musculoskeletal dealmaking in the biopharma industry since 2016 Access to headline, upfront, milestone and royalty data Access to hundreds of musculoskeletal deal contract documents Comprehensive access to over 600 musculoskeletal deal records The leading musculoskeletal deals by value since 2016 Most active musculoskeletal dealmakers since 2016 The report includes deals for the following indications: Arthritis, Ankylosing spondylitis, Juvenile arthritis, Osteoarthritis, Psoriatic arthritis, Rheumatoid arthritis, Bone fracture, Hip, Carpel tunnel syndrome, Frozen shoulder, Gout, Knee, Meniscus damage, Muscular dystrophy, Osteoporosis, Paget's disease, Spinal muscular atrophy, Bone pain, Back pain, Muscular pain, Stiffness, Weakness, plus other musculoskeletal indications. In Global Musculoskeletal Partnering 2016 to 2023, available deals and contracts are listed by: Headline value Upfront payment value Royalty rate value Stage of development at signing Deal component type Technology type Specific therapy indication Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand. The Global Musculoskeletal Partnering 2016-2023 report provides comprehensive access to available deals and contract documents for over 600 musculoskeletal deals. Analyzing actual contract agreements allows assessment of the following: What are the precise rights granted or optioned? What is actually granted by the agreement to the partner company? What exclusivity is granted? What is the payment structure for the deal? How are the sales and payments audited? What is the deal term? How are the key terms of the agreement defined? How are IPRs handled and owned? Who is responsible for commercialization? Who is responsible for development, supply, and manufacture? How is confidentiality and publication managed? How are disputes to be resolved? Under what conditions can the deal be terminated? What happens when there is a change of ownership? What sublicensing and subcontracting provisions have been agreed? Which boilerplate clauses does the company insist upon? Which boilerplate clauses appear to differ from partner to partner or deal type to deal type? Which jurisdiction does the company insist upon for agreement law? Key Topics Covered: Chapter 1 - Introduction Chapter 2 - Trends in musculoskeletal dealmaking 2.1. Introduction 2.2. Musculoskeletal partnering over the years 2.3. Musculoskeletal partnering by deal type 2.4. Musculoskeletal partnering by industry sector 2.5. Musculoskeletal partnering by stage of development 2.6. Musculoskeletal partnering by technology type 2.7. Musculoskeletal partnering by therapeutic indication Chapter 3 -Financial deal terms for musculoskeletal partnering 3.1. Introduction 3.2. Disclosed financials terms for musculoskeletal partnering 3.3. Musculoskeletal partnering headline values 3.4. Musculoskeletal deal upfront payments 3.5. Musculoskeletal deal milestone payments 3.6. Musculoskeletal royalty rates Chapter 4 - Leading musculoskeletal deals and dealmakers 4.1. Introduction 4.2. Most active in musculoskeletal partnering 4.3. List of most active dealmakers in musculoskeletal 4.4. Top musculoskeletal deals by value Chapter 5 - Musculoskeletal contract document directory 5.1. Introduction 5.2. Musculoskeletal partnering deals where contract document available Chapter 6 - Musculoskeletal dealmaking by therapeutic target 6.1. Introduction 6.2. Deals by musculoskeletal therapeutic target Companies Mentioned 3D-Side 3SBio A2A Pharmaceuticals Aavis Pharmaceuticals Abarca Abbvie AbCellera AC Bioscience Accenture Actigraph Activbody Active Implants Adaptive Health Additive Orthopaedics Advanced Human Imaging AdventHealth Affinia Therapeutics AGC Asahi Glass AgNovos Healthcare AgomAb Therapeutics Akashi Therapeutics AKL Research and Development AlfaMed Aligos Therapeutics AliMed Alkem Laboratories Allergan AlloSource Almirall Alpine Immune Sciences Altamira Bio Altasciences Alvogen Alvotech Ambry Genetics Amedica Amend Surgical American Association of Neuromuscular & Electrodiagnostic Medicine Amgen Amneal Pharmaceuticals AMRA AMRA Medical Anagenesis Biotechnologies Analysis Group AnaMar Angelini Pharma Angers University Anika Therapeutics ANI Pharmaceuticals Antares Pharma Antibe Therapeutics Apexigen Apple Apsen Farmacutica Aptahem Aptorum Group Aralez Pharmaceuticals Aratana Therapeutics Aravive Biologics argenx ARK Crystal Arrowhead Pharmaceuticals Arthrex Arthrosi Therapeutics Artialis Asahi Kasei Ascendis Pharma AskAt Asklepios Biopharmaceutical Assertio Therapeutics Astellas Pharma AstraZeneca Athrotech Atnahs Pharma Audentes Therapeutics Aurinia Pharmaceuticals Australian Research Council Autotelic BIO Avalere Health Avanos Medical Aveta Biomics AveXis Avidity Biosciences Avion Pharmaceuticals AWB Schraubtechnik und Industriebedarf Axovant Gene Therapies Azellon Cell Therapeutics Aziyo Biologics Back-A-Line Bacterin International Baebies Bamboo Therapeutics Bauerfeind Baxalta Bayer Baylor College of Medicine Bazis NN BC Platforms Beijing Tide Pharmaceutical Benitec Biopharma Berg BGI BillionToOne Bio-Thera Solutions BioAge Labs BioCanRx Biocomposites Biogen BioGen Medical Biohaven Pharmaceuticals BioInvent BioMarin Pharmaceutical BioMed X Innovation Center BionX Medical Technologies BioPharma Forest Bioqube Ventures Bioservo Technologies Biosolution Biosplice Bioventus BioVinc Bison & Rose Blue Belt Technologies Blueprint Medicines Bodycad Boehringer Ingelheim Bone Biologics Bone Therapeutics Brickell Biotech Brigham and Women's Hospital Bristol-Myers Squibb BRM Extremities BSN Medical Burke Therapeutics c-LEcta California Institute for Biomedical Research California Institute for Regenerative Medicine Calimmune Calliditas Therapeutics Camargo Pharmaceutical Services Camber Spine Technologies Can-Fite BioPharma CANbridge Pharmaceuticals Cantargia Capricor Therapeutics Capsigen CareFirst BlueCross BlueShield Carlsmed Carna BioSciences CartiHeal Cartiva CAS Casper Pharma Catabasis Pharmaceuticals Catalyst Pharmaceuticals cbdMD Cedars-Sinai Medical Center Celgene Celltech Cellthera Pharma Cell Therapy Catapult Celltrion Cellular Biomedicine Cel Sci Centinel Spine Centogene Cerhum For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. 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