Emerson Resources, Inc.

Recent technol. improvements have made acrylics the preferred system for the aqueous enteric coating of tablets.The use of acrylic enteric emulsions in aspirin was studied.Three commonly marketed dosages of aspirin tablets (81, 325, and 500 mg) were compacted.The anal. testing results for all three dosage forms, including both those stored at room temperature and those stored under accelerated stability conditions, with and without desiccant, were within the specified criteria for passing results.The pos. results of these tests demonstrate the advances that have been made in acrylic polymers for aqueous enteric coating of tablets.

Historically, acrylic coatings were unstable and tended to agglomerate easily, making them difficult to use.Improvements in acrylic systems and the techniques used to apply them have resulted in them being widely used for aqueous enteric coatings.Acrylic resins are now more stable and can be used with glycerides as detackifiers instead of talc, making their application much easier.Color can also be incorporated into the enteric system, making a final color layer over a clear enteric film redundant.The study on the use of acrylic enteric emulsions in aspirin provides a clear indication of the improvements that have been made in these systems.The anal. testing results for all three dosage forms evaluated (81-, 325-, and 500-mg aspirin), including both those stored at room temperature and those stored under accelerated stability conditions, with and without desiccant, were within the specified criteria for passing results.The pos. results of these tests demonstrate the advances that have been made in acrylic polymers for aqueous enteric coating of tablets.