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Although many scientists have used pectin, its feasibility in terms of tablet manufacturability with a high speed machine has never been evaluated.Therefore, compactibility of different pectin types for large scale tableting operation has been evaluated.The compactibility behavior of powder pectins was studied by a compaction simulator.It was found that pectin on its own does not produce tablets of acceptable quality even at a punch velocity as low as 20 rpm (e.g. low tensile strengths, capping and lamination irresp. of applied compression force).Thus, dwell time was introduced and more hard compact was produced as relaxation time in die increases.It was concluded that frequent structural failure observed in both pectin types was due to lack of plastic deformation, poor compactibility and high elastic recovery.

Yakhak Hoechi

Antifungal activities of trans-cinnamaldehyde derivatives

作者: Jo, Gune-Hee ; Bang, Kyu-Ho ; Rhee, Young-Ha

Antifungal activities of trans-cinnamaldehyde (CA) derivatives including com. CA derivatives as well as synthesized CA derivatives against various human pathogenic fungi were investigated.Among the derivatives tested, α-chlorocinnamaldehyde, α-bromocinnamaldehyde and 7-phenyl-2,4,6-heptatrienal were more potent than CA in antifungal activity.α-Bromocinnamaldehyde was the most effective in inhibiting the growth of representative fungi of dermatomycosis with min. inhibitory concentration (MIC) of 0.61 ∼ 9.76 μg/mL.In the structure-activity relationship, introduction of the chlorine and bromine group into the C-2 of CA resulted in the decrease of MIC.Derivative with more double bonds exhibited the increase of antifungal activity against various pathogenic fungi.

Yakhak Hoechi

Screening of the antifungal activity from natural products against Candida albicans and Penicillium avellaneum

作者: Lee, Jun Sung ; Min, Byung Sun ; Bae, Ki Hwan ; Bang, Kyu Ho

For the research of antifungal active constituents from natural products, 226 plants were extracted with ether and methanol, sep., and screened antifungal activity against Candida albicans and Penicillium avellaneum cells.The results demonstrated that 30 samples showed antifungal activity in ether or methanol extracts and 17 samples in ether extracts and 20 samples in methanol extracts against C. albicans.Against P. avellaneiu, 19 samples showed antifungal activity in ether or methanol extracts and 17 samples in ether extracts and 11 samples in methanol extracts, resp.The antifungal activity of natural products against C. albicans were showed more sensitive than P. avellaneum, and the polarity of the solvent was not specific in antifungal activity.

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