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更新于：2025-08-15
Southwest Jiaotong University
更新于：2025-08-15
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肿瘤
消化系统疾病
泌尿生殖系统疾病
小分子化药
蛋白水解靶向嵌合体（PROTAC）
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公司药物应用最多的技术
靶点
公司最常开发的靶点
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原研机构 |
在研适应症 |
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ChiCTR-ROC-15007259
Working ability tests of tunnel construction workers at high-altitude conditions
100 项与 西南交通大学 相关的临床结果
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2026-02-01BIOMATERIALS
Reversible shear stress-mediated mechanoregulation of endothelial cell function in thixotropic hydrogels via L-type Ca2+ channel and focal adhesion molecules for accelerated vascularization
Article
作者: Qu, Shuxin ; Xie, Chaoming ; Jing, Tao ; Li, Sumei ; Gou, Xue ; Peng, Haodong ; Lin, Feng ; Wang, Ran ; Li, Zhongtao ; Cui, Rongwei ; Weng, Jie
Developing functional vascular networks in engineered tissues is crucial for regenerative medicine. Recently, thixotropic hydrogel has emerged as a promising approach due to their 3D-printability and force-responsive dynamics. However, their gel-sol transitions under physiological loading and subsequent mechanoregulation mechanism on vascularization remains inadequately explored. Here, the reversible shear stress induced in thixotropic hydrogels under bionic cyclic stretching (5 % strain, and 0.5, 1 or 1.5 Hz) has been demonstrated to significantly accelerate endothelial cell adhesion, migration, and angiogenesis. These dynamic mechanical responses are precisely quantified and monitored through computational simulations and specially designed experimental apparatus. Mechanistic investigations reveals that the mechanically regulated cell behavior is mediated by cell adhesion molecules and calcium signaling pathways, which can be inhibited using Talin bloker (e.g., neomycin) and L-type voltage-gated calcium channel antagonists (e.g., verapamil), respectively. Furthermore, subcutaneous implantation of thixotropic hydrogels in rats results in denser and more rapid vascularization compared to non-thixotropic hydrogels. The reversible shear stress-regulated vascularization strategy is anticipated to offer a novel and efficient approach for constructing functional blood vessels in regenerative medicine.
2026-01-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
An activatable NIR-I superoxide anion fluorescent probe selective for tracking cerebral ischemia-reperfusion injury
Article
作者: Ma, Yu ; Zhang, Lu ; Wang, Ya-Wen ; Feng, Yu-An ; Xu, Long-Zhou ; Tan, Rui ; Peng, Yu ; Xie, Chun
A series of nine near-infrared (NIR) fluorescent probes (DT-A1-DT-A8 and SWJT-37) was designed and synthesized featuring trifluoromethanesulfonate moieties as O2•- recognition groups. Through systematic testing, SWJT-37 emerged as the optimal NIR fluorescent probe, exhibiting high selectivity, remarkable sensitivity, and a 51-fold fluorescence enhancement towards O2•-. The probe demonstrated an exceptionally low detection limit (3.88 nM), surpassing most reported O2•- probes. SWJT-37 successfully enabled imaging of endogenous O2•- in HeLa and HT22 cells. More importantly, a significant increase in O2•- level was observed in a cerebral ischemia-reperfusion injury (CIRI) rat model using the probe, which indicating that SWJT-37 has been successfully applied in CIRI rat models.
2025-12-31Journal of Oral Microbiology
Sodium houttuyfonate inhibits the cariogenic virulence of
Streptococcus mutans
through the downregulation of VicRK two components pathway
Article
作者: Ren, Biao ; Yao, Lin ; Yang, Guang ; Chi, Yaqi ; Zou, Ling ; Fu, Di ; Wei, Mingying ; Wang, Ye ; Zhou, Ge
Background:
Caries is one of the most common diseases worldwide, and Streptococcus mutans is considered to be the primary cariogenic pathogen of dental caries. Sodium houttuyfonate (SH) has showed potential antibacterial effects, however, its actions and mechanisms on S. mutans and cariogenicity remain unclear and need further study.
Materials and Methods:
we investigated the effects of SH on the cariogenic ability of S. mutans, including growth, biofilm formation, exopolysaccharides (EPS) and acid productions. RNA-Seq and mutants' validation were also performed to explore the mechanisms of SH on S. mutans. The dental caries rat model was finally employed to evaluate the anti-caries capabilities of SH.
Results:
The MIC of SH against S. mutans was 64 μg/mL. SH inhibited biofilm formation and cariogenic virulence of S. mutans, including EPS and acid productions, in a dose-dependent manner. RNA-seq analysis indicated that SH significantly downregulated the VicRK pathway, a key pathway regulating biofilm formation and EPS generation. The ΔvicK, ASvicR, ΔgtfB and ΔgtfBC mutants were more sensitive to SH, while VicK and VicR overexpression strains OEvicK and OEvicR were more resistant to SH than WT strains, indicating that SH downregulated the VicRK pathway to inhibit the cariogenicity of S. mutans. SH also significantly inhibited the development of dental caries in rats without systematic toxicities. The expressions of S. mutans VicK, VicR, GtfC and GtfD genes from rat plaques were downregulated by SH.
Conclusion:
This study suggested SH inhibited the cariogenic virulence of S. mutans through the downregulation of VicRK two components pathway, thereby offering novel insights for clinical caries prevention.
100 项与 西南交通大学 相关的药物交易
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100 项与 西南交通大学 相关的转化医学
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2025年08月26日管线快照
管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期
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