预约演示
更新于：2026-04-23
Soochow University
更新于：2026-04-23
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肿瘤
其他疾病
消化系统疾病
小分子化药
单克隆抗体
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疾病领域得分
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公司药物应用最多的技术
靶点
公司最常开发的靶点
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靶点 |
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非在研适应症 |
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首次获批日期 |
靶点 |
作用机制 |
在研机构 |
原研机构 |
在研适应症 |
非在研适应症 |
最高研发阶段 |
首次获批国家/地区 |
首次获批日期 |
ChiCTR2600122787
The Effect of High-Resolution Music on Sleep and Cognitive Function of Older People with Sleep Disorders in Residential Care Homes
ChiCTR2600121916
Assessment and Latent Class Analysis of Physiological Mechanisms in Balance Deficits in Older Adults
ChiCTR2600120385
The influence of rhythmic movement intervention on the sensory integration ability and physical fitness development of healthy preschool children aged 5-6
100 项与 Soochow University 相关的临床结果
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2026-12-31ANNALS OF MEDICINE
Preoperative neutrophil-to-lymphocyte ratio and refracture risk in hip fracture patients: a propensity score-matched analysis
Article
作者: La, Rui ; Huang, Lixin ; Xu, Rui ; Wang, Shenghao ; Wu, Qian ; Zhu, Hongxia ; Zhang, Zhigang ; Xu, Wu ; Zu, Haiyue ; Zhang, Zhongtai ; He, Zhiyuan ; Ding, Wenquan ; Ding, Qingfeng ; Kong, Fanqi
BACKGROUND:
The relationship between preoperative neutrophil-to-lymphocyte ratio (NLR) and refracture risk in hip fracture patients remains unclear.
METHODS:
This retrospective study included 701 patients with hip fractures between 2018 and 2020. Multivariate logistic regression and propensity score matching (PSM) assessed the association between preoperative NLR (analysed as a continuous variable) and refracture risk, adjusting for age, sex, comorbidities, fracture characteristics and laboratory parameters. Subgroup and dose-response analyses evaluated robustness.
RESULTS:
Refracture occurred in 119 patients (16.98%). Each unit increase in NLR (as a continuous variable) was associated with 8.0% increased refracture odds (odds ratio (OR) = 1.080, 95% confidence interval (CI) = 1.019-1.144, p = 0.009). PSM confirmed this association (crude OR = 1.119, p = 0.006; adjusted OR = 1.108, p = 0.014). The association remained consistent across patient subgroups (all p for interaction > 0.05) with a linear dose-response relationship.
CONCLUSIONS:
Elevated preoperative NLR independently predicts refracture risk in hip fracture patients. This readily available biomarker may facilitate risk stratification and guide prevention strategies.
2026-12-31Gut microbes reports
Article
作者: Hernalsteens, Saartje ; Lyu, He ; Zheng, Qijun ; Chen, Xiao Dong ; Yu, Aibing
Gastrointestinal digestion shapes nutrient availability and microbial substrates in early life, yet how milk digestion products regulate probiotic-pathogen dynamics remains unclear. Using in vitro digestion products of human milk (HM), infant formula (IF), and control milk (CM), we evaluated the fermentation responses of Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis subsp. lactis BB-12 (BB-12), and Escherichia coli (E. coli) in static reactors (ST) and peristalsis-mimicking soft elastic tubular reactors (SETR). HM-derived residues selectively enhanced probiotic activity by increasing reducing-sugar utilization, acidification (ΔpH), and overall metabolic output by 110% (LGG) and 130% (BB-12), while suppressing E. coli growth by 28%. In the absence of digestive products, LGG and BB-12 declined by 0.99 and 3.19 log units, whereas E. coli increased by 0.33 log. Mechanical compression in SETR further boosted BB-12 metabolic output by 23% compared with ST. These results demonstrate that infant milk digestion products differentially regulate microbial strategies. We acknowledge that this simplified three-strain model does not capture full gut community complexity, and broader consortia studies are needed for future validation.
2026-12-31Emerging Microbes & Infections
TOR3A represses type I interferon production and limits viral clearance during respiratory syncytial virus infection
Article
作者: Zhang, Jinping ; Li, Cancheng ; Gao, Xiu ; Dai, Xiaoqiu ; Dong, Chunsheng ; Huang, Jiaqi ; Ye, Yunfei ; Xu, Xuena ; Li, Xiaoping ; Chen, Zhengrong ; Tan, Chensheng ; Hu, Jingjing ; Wang, Yufeng ; Qiao, Guodong ; Li, Jiaoyang ; Cai, Jiamin ; Xu, Fei ; Zhu, Peijie ; Hao, Chuangli ; Shao, Yu ; Yang, Yi ; Zhou, Ying ; Zhou, Ji ; Wu, Mengyun
Type I interferons (IFN-I) are essential for antiviral immunity, and precise regulation of IFN-I production is crucial to balance viral clearance and immunopathology. Here, we demonstrate that the interferon-stimulated gene TOR3A negatively regulates type I IFN signalling during respiratory syncytial virus (RSV) infection. TOR3A expression was upregulated in macrophages and RSV-infected patients, and its deficiency enhanced antiviral responses, leading to reduced viral load. Mechanistically, RSV infection induced TOR3A expression through the IFN-STAT1 pathway, which in turn suppressed IFN-I production. Furthermore, TOR3A recruited the E3 ubiquitin ligase STUB1 to mediate K48-linked ubiquitination and proteasomal degradation of RIG-I at lysine 146, thereby promoting RSV immune evasion. Our study identifies TOR3A as a novel suppressor of antiviral immunity and uncovers a mechanism by which RSV exploits host ISGs to dampen IFN-I responses, providing new insights into viral pathogenesis and potential therapeutic strategies.
100 项与 Soochow University 相关的药物交易
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100 项与 Soochow University 相关的转化医学
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