Octapharma AG

DUBLIN--( BUSINESS WIRE )--The "The Corporate Reputation of Pharma in 2023/2024 - The Patient Perspective - USA Edition - The Views of 314 USA Patient Groups" report has been added to ResearchAndMarkets.com's offering. This review contains the results of a November 2023 to late-February 2024 survey, answered by 314 US-based patient groups. The 314 respondent US patient groups specialised in a wide range of therapy areas - the largest representation (113 respondent patient groups) being cancer patient groups. The 314 stated that, collectively, they had actively supported and served some 12 million US patients during 2023/2024. Continue reading, for details about: The headline US industry-wide results of the 2023 survey. The performance of the individual pharma companies included in the 2023 US analysis. Summary of Results Industry Wide Several issues in 2023 may have influenced the opinions of US patient groups responding to the 2023 'Corporate Reputation of Pharma' survey, including: the affordability of prescription drugs, and shortages of prescription drugs. On the latter subject, drug shortages reached an all-time high in the US during the first three months of 2024 (which included the final two months of the 2023 'Corporate Reputation' survey period). The perception of the pharma industry's reputation among respondent US patient groups declined in 2023, with 57% rating the industry's reputation as "Excellent" or "Good", compared with 65% saying the same in 2022. The year before that, the COVID-affected year of 2021, had seen the industry's positive rating peak at 67%. Between 2022 and 2023, sharp declines were reported by respondent US patient groups for: the quality of pharma's patient-group relations; its provision of patient information; and its ability to improve access to medicines. And, despite pharma's commitment to involving patients more in R&D, only 35% of 2023's respondent US patient groups rated the industry "Excellent" or "Good" at this - the first such decline in five years. Key Insights: The corporate reputation of pharma in the US, 2019-2023 Percentage of respondent US patient groups stating "Excellent" or "Good" How good or bad the pharma industry was at carrying out specific activities in the US, 2023 v. 2022 % of respondent US patient groups stating "Excellent" or "Good" What US patient groups say about pricing The US runs a complex pricing-and-reimbursement system - which also happens to be in a state of considerable flux. 2023's respondent US patient groups urge all companies to be as transparent as possible, and to work with other healthcare stakeholders in supporting patients who cannot afford new medicines (and who do not qualify for federal funding). With new medicines averaging $300,000 list price in the US in 2023 - an increase of more than 35% over 20223 - the issue of pricing is likely to remain a top patient concern in the US for the foreseeable future. "Somehow, the medications are available in other countries for much less, but we are billed/paying co-pays and deductibles that far outpace the costs of other health systems. So why? Let's talk about it." - National breast-cancer patient group, USA "Think about patients, when making pipeline decisions - even in light of the IRA [Inflation Reduction Act]. Patients before profits." - National lung-cancer patient group, USA "Companies should not treat patient engagement as if they are ticking off boxes. There should be meaningful engagement, co-led by patients and community organizations, that benefits everyone, and shows commitment to the patient community. Companies should reach out early in the R&D process." - National hepatitis patient group, USA "It is extremely difficult to maintain relationships, due to constant changes of [company] employees." - National rare-disease patient groups, USA "From our limited outreach to the pharma industry, I understand that they receive many requests, and have many layers of compliance. However, it is difficult, if not impossible, to understand the best way for patient-advocacy groups to work with pharma, and retain their independence." - National skin-conditions patient group, USA Companies included in the US element of the 2023 'Corporate Reputation' survey The 37 companies featured in the US arm of the 2023 'Corporate Reputation of Pharma' survey were selected on the criteria of size of revenue, or, by request from companies or patient groups. They include: AbbVie Amgen Astellas Pharma AstraZeneca Bayer Biogen Biomarin Boehringer Ingelheim Bristol Myers Squibb Chiesi Farmaceutici CSL Behring Daiichi Sankyo Eisai Eli Lilly Ferring Gilead Sciences Grifols GSK Ipsen Janssen Lundbeck Menarini Merck & Co Merck KGaA/EMD Serono Novartis Novo Nordisk Octapharma Otsuka Pfizer PTC Therapeutics Roche/Genentech Sanofi Servier Takeda UCB Vertex ViiV Healthcare Companies are assessed on issues of importance to patient groups Individual Company Findings for the USA, 2023 - and the Fastest Risers in the Rankings, 2023 v. 2022 The top-three rankings in the US in 2023 - out of all 37 companies As assessed by respondent US patient groups familiar with the company: Servier, 1st ViiV healthcare, 2nd Amgen, 3rd The top-three rankings in the US in 2023 (out of 32 companies) As assessed by respondent US patient groups working with the company: ViiV Healthcare, 1st Servier, 2nd Gilead Sciences, 3rd The top-three rankings in the US in 2023 - out of 15 'big-pharma' companies As assessed by respondent US patient groups familiar with the company: Amgen, 1st Gilead Sciences, 2nd Pfizer, 3rd As assessed by respondent US patient groups working with the company: Gilead Sciences, 1st Amgen, 2nd Roche/Genentech, 3rd Key Insights: The companies rising the most in the upper rankings in the US (out of all 37 companies), 2023 v. 2022, as assessed by respondent US patient groups familiar with the company. The companies rising the most in the upper rankings in the US (out of 32 companies), 2023 v. 2022, as assessed by respondent US patient groups working with the company. For more information about this report visit https://www.researchandmarkets.com/r/qouqv6 About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

WEDNESDAY, Aug. 7, 2024 -- For patients with preoperative iron deficiency anemia (IDA), intravenous (IV) iron treatment is associated with a significant reduction in 30-day postoperative mortality and morbidity compared with red blood cell (RBC) transfusion, according to research published online July 22 in Anesthesia & Analgesia . Una E. Choi, from the Johns Hopkins University School of Medicine in Baltimore, and colleagues conducted a propensity score-matched retrospective cohort analysis from 2003 to 2023 to examine trends in preoperative IDA treatment among surgical patients diagnosed with IDA within three months preoperatively. A cohort of 77,179 patients with preoperative IDA who were treated with preoperative IV iron but not RBCs was compared to a cohort of 77,179 patients receiving preoperative RBCs but not IV iron. The researchers found that preoperative IV iron was associated with a lower risk for postoperative mortality and a lower risk for postoperative composite morbidity compared with RBC transfusion (relative risks, 0.63 and 0.76, respectively). IV iron was associated with higher hemoglobin in the 30-day postoperative period (10.1 ± 1.8 versus 9.4 ± 1.7 g/dL) and a reduced incidence of postoperative RBC transfusion (relative risk, 0.30) compared with RBC transfusion. "This change in practice represents a promising opportunity to continue to improve outcomes and reduce avoidable blood transfusions along with their associated costs," the authors write. One author disclosed ties to Octapharma; another author disclosed ties to Haemonetics.

PARAMUS, N.J, Aug. 1, 2024 /PRNewswire/ -- Octapharma USA, Inc. has announced the expanded approval of fibryga®, Fibrinogen (Human) Lyophilized Powder for Reconstitution, for fibrinogen replacement in bleeding patients with acquired fibrinogen deficiency (AFD) by the U.S. Food and Drug Administration (FDA). As the first and only on-demand, virus-inactivated, human plasma-derived fibrinogen concentrate option with this approval, fibryga represents a rapid and more precise option for severe bleeding scenarios than the current standard of care (cryoprecipitate). Fibrinogen plays an important role in coagulation and blood clotting in emergency and surgical settings. Fibrinogen is the first coagulation factor to drop to critically low levels during severe bleeding episodes. Rapid replenishment of fibrinogen is essential for achieving hemostasis in bleeding patients. Acquired fibrinogen deficiency (AFD) often results from severe bleeding and can impair blood clot formation, increasing the risk of ongoing hemorrhage in patients. Cryoprecipitate, which was introduced in 1964, comes with significant drawbacks, including long thawing and preparation processes, variable levels of fibrinogen, inclusion of additional coagulation-dependent components, and a higher risk of viral transmission. The approval of fibryga for AFD is a major advancement from the current standard of care. As a lyophilized powder, it can be stored at room temperature or refrigerated and can be quickly reconstituted at the point of patient care. It's precise and delivers a highly purified and consistent amount of fibrinogen for accurate treatment. "In the surgical theater, time matters. And confidence matters. This expanded FDA approval of fibryga represents a major step forward in our commitment to redefining the standard of care for patients experiencing major bleeding. It provides an important option for providers who must act urgently," said Flemming Nielsen, President, Octapharma USA, Inc. "We are proud to be the first to offer this therapeutic advancement—and a new standard of care—to hospitals, anesthesiologists, surgeons, OB/GYNs, and patients across the United States." The expanded FDA approval of fibryga was based on the FIBRES [FIBrinogen REplenishment in Surgery] study published in JAMA, which was a head-to-head, multicenter, randomized clinical trial in 735 patients, demonstrating that fibrinogen concentrate was non-inferior to cryoprecipitate and may be used instead of cryoprecipitate for the treatment of bleeding related to AFD. Fibryga has already received regulatory approval for the treatment of AFD in both the European Union in 2019 and Canada in 2020. Today's approval marks the third FDA approval received to date for fibryga. In 2017, the FDA granted an approval for acute bleeding episodes in adults and adolescents with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia. A second was received in 2020 for pediatric patients under 12 years for treatment of acute bleeding episodes in congenital fibrinogen deficiency. "The recent FDA approval is the result of years of dedicated research and development in fibrinogen replacement," commented Huub Kreuwel, Ph.D., VP of Medical Affairs at Octapharma USA, Inc. "Fibryga's expanded indication will allow practitioners and health systems to support a broader range of patients with serious bleeding complications who require fibrinogen replacement therapy." The medical community has welcomed this approval as a significant advancement in patient care for those with AFD. "This first-in-class FDA approval for fibryga, a fibrinogen concentrate with an expanded indication to treat bleeding patients urgently in need of fibrinogen replacement, is an important step toward improving patient safety and outcomes. Compared to cryoprecipitate, fibrinogen concentrate allows for targeted dosing and faster treatment of low fibrinogen in maternal hemorrhage," states John Kowalczyk, MD, and Michaela Farber, MD, MS, Division of Obstetric Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Octapharma is committed to working closely with healthcare providers and patient organizations to ensure broad access to fibryga for those who can benefit from it. For more information about the FIBRES study, please review our journal publication: Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery The FIBRES Randomized Clinical Trial Indications and Important Safety Information for fibryga Indications and Usage Fibryga is a human fibrinogen concentrate indicated for fibrinogen supplementation in bleeding patients with acquired fibrinogen deficiency and in treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia. Fibryga is not indicated for dysfibrinogenemia. Contraindications Fibryga is contraindicated in individuals who have manifested severe immediate hypersensitivity reactions, including anaphylaxis, to fibryga or its components (Sodium Citrate Dihydrate; Glycine; L-Arginine Hydrochloride). Warnings and Precautions Monitor patients for early signs of hypersensitivity or allergic reactions. If necessary, discontinue administration and institute appropriate treatment. Thrombotic events have been reported in patients receiving fibryga. Treatment with human fibrinogen concentrate has been associated with thrombosis at target plasma fibrinogen levels that were below 150 mg/dL. The thrombotic risks may be greater when the target fibrinogen plasma level is 150 mg/dL. Weigh the benefits of administration versus the risks of thrombosis. Fibryga is made from pooled human plasma. Products made from human plasma may contain infectious agents, e.g., viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. Adverse Reactions The most serious adverse reactions observed with fibryga are thromboembolic episodes and anaphylactic-type reactions. The most common adverse reactions observed in clinical studies with fibryga in acquired fibrinogen deficiency (>5% of patients) were abnormal hepatic function, acute kidney injury, anemia, atrial fibrillation, delirium and renal failure. The most common adverse reactions observed in clinical studies with fibryga in congenital fibrinogen deficiency (>5% of patients) were nausea, vomiting, pyrexia (fever) and thrombocytosis. Please see fibryga full Prescribing Information. For more information about fibryga, please visit fibrygausa.com. About Octapharma and Octapharma USA Headquartered in Lachen, Switzerland, Octapharma is one of the largest human protein manufacturers in the world, developing and producing human proteins from human plasma and human cell lines. Octapharma employs nearly 12,000 employees worldwide to support the treatment of patients in 118 countries with products across three therapeutic areas: Immunotherapy, Hematology, and Critical Care. Octapharma has seven R&D sites and five state-of-the-art manufacturing facilities in Austria, France, Germany and Sweden, and operates more than 190 plasma donation centers across Europe and the US. Octapharma has 40 years of experience in patient care. The company's American subsidiary, Octapharma USA, Inc., is located in Paramus, N.J. For more information, please visit octapharmausa.com. SOURCE Octapharma