QureBio Ltd.

SHANGHAI, Nov. 6, 2024 /PRNewswire/ -- QureBio Ltd., a clinical-stage biopharmaceutical company focusing on development of bispecific antibodies and other engineered Biopharmaceuticals for the treatment of cancer, inflammation, and other serious disorders, today announced that Phase Ⅱ Clinical Data of its Q-1802 program will be presented at SITC 39th annual meeting hold at Houston on November 8–9, 2024. The abstract will be found in 39th SITC annual meeting abstract (#1500), meanwhile the poster will be presented on November 9 at George R. Brown Convention Center level 1 exhibit Halls AB, Houston. A brief of the abstract information is shown as below: A phase II trial of bispecific antibody Q-1802 in patients with relapsed or refractory solid tumors Authors: Yakun Wang, Jifang Gong, Xiangdong Qu, Lin Shen Q-1802 can target both the tumor-specific antigen Claudin18 isoform 2 (CLDN18.2) and the immune checkpoint PD-L1. The objective response rate (ORR) is approximately 70.0% (14/20) in the 10 mg/kg group. The proportion of Grade 3 and above adverse events in the 10 mg/kg group is approximately 55%, with good safety profile. There is no adverse events above Grade 3 and Q-1802 related death. Clinical Data shows that Q-1802 has significant anti-tumor activity. About Q-1802 Q-1802, a humanized bispecific antibody, is the first FDA-approved and the first enter clinical trial Claudin18.2/PD-L1 bispecific antibody. It recruits multiple immune mechanisms to kill tumor cells, such as antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP), offering a novel therapeutic opportunity for Claudin18.2 positive solid tumors. Q-1802 exhibits high affinity and selectivity, and patients with low or high expression of CLDN18.2 can benefit from it. The molecular design of Q-1802 is rational and effective, the production process is robust with high yield. Also in this conference, QureBio revealed its T-cell engage and T cell engager enhancer platforms, which can be used to develop bispecific antibodies to treat cancer and autoimmune diseases. About QureBio Ltd. QureBio Ltd. is a clinical-stage biopharmaceutical company focusing on innovative biopharmaceuticals for urgent and unmet clinical needs, such as the treatment of refractory cancers, inflammation and other serious disorders, founded by experienced scientists from the relevant fields, QureBio Ltd. has built up a series of proprietary technologies for engineered bio-macromolecules, including innovative platforms for bi-specific and tri-specific antibodies. Founded in 2017 with seed capital from Viva Bio-Innovator, QureBio Ltd. has since received a series of funds from Jundu Investment, Watson Capital, Shenzhen Capital Group, New value Capital, Bocom Industrial Investment (Hangzhou) Equity Investment Partnership, Suzhou Oriza Holdings, Hangzhou CAPITAL GuoShun, Zhuhai Longmen Capital Management, Shanghai Pudong Kechuang Group, Shenzhen Lihe Hongxin Venture and Three Rivers Capital. QureBio Ltd. has secured a Series-B funding of nearly 200 million CNY. QureBio Ltd. engages in collaboration with partners to develop novel therapeutics for unmet medical needs and has on-going cooperation with a series of industrial partners including BRL Medicine, Precision Scientific, and Hengrui Pharmaceuticals. Contact Us: Tel: +86 21-61622561 BD: Email: [email protected] Website: Address: 1227 Zhangheng Road, Building 1st, Room 206, Pudong New Area, Shanghai Postal Code: 201203 SOURCE QureBio Ltd. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

HONG KONG, June 2, 2023 /PRNewswire/ -- Even with the ever-changing situation, technological innovation is still the most critical component for biopharmaceutical companies' long-term development. This continuous innovation keeps companies up to date and promotes the evolution of R&D and the success of commercialization. Recently, 9 of Viva's portfolio companies have achieved significant results and progress. Keep reading for more details. Triumvira to Present Phase I/II Data of TAC01-HER2 in Clinical Trial TACTIC-2 at the 2023 ASCO Annual Meeting AUSTIN, Texas and HAMILTON, ON and SOUTH SAN FRANCISCO, Calif., May 16, 2023 /PRNewswire/ -- Triumvira Immunologics, invested and incubated by Viva BioInnovator (VBI), is a clinical-stage company developing novel, targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with solid tumors. They announced that the Company will be presenting clinical data on its lead asset TAC01-HER2 for the treatment of human epidermal growth factor receptor 2 (HER2) positive solid tumors at the 2023 American Society Of Clinical Oncology (ASCO) Annual Meeting, taking place in Chicago, IL, June 2-6. The presentation by Benjamin L. Schlechter, MD, from Harvard Medical School and a Senior Physician in Gastrointestinal Oncology at the Dana-Farber Cancer Institute, will highlight updated clinical data from the ongoing Phase I/II trial of TAC01-HER2 (NCT04727151) in patients with relapsed or refractory solid tumors. AIxplorerBio Collabora ted with BioMap for IBD Synergistic Dual-Target Mining Research, and Collaborated with Baidu's PaddleHelix to Integrate Drug Efficacy Prediction Method Recently, AIxplorerBio, invested and incubated by Viva BioInnovator (VBI), announced a further collaboration with BioMap. Both parties will leverage AIxplorerBio' AIxMol® drug discovery technology platform and BioMap's AIGP platform to conduct collaborative dual-target mining research in the field of inflammatory bowel disease (IBD). The objective of this collaboration is to deepen the understanding of cellular and systemic mechanisms, with the aim of identifying more effective target combinations in the field of autoimmune diseases. Together, they will explore target combinations for IBD, aiming to provide innovative solutions for IBD treatment. Besides, since May 2022, AIxplorerBio has established a broad collaboration with Baidu's PaddleHelix in multiple areas, including de novo molecule design and optimization as well as draggability parameter predictions. In the evaluation of compounds' druggability, AIxplorerBio has target-optimized PaddleHelix's HelixADMET and integrated it into the company's AI drug discovery platform (AIxMol®). The platform has been successfully applied to the company's pipeline projects, helping the company deliver three Pre-clinical Compound Candidate (PCC) molecules in just 18 months. AIxplorerBio will continue to collaborate with industry leaders like Baidu to improve the functionality and efficiency of its AIxMol® platform to develop differentiated products more efficiently. VivaVision Announced the Completion of Over 100 million RMB in Series D2 Financing Recently, VivaVision, a company incubated and invested by Viva BioInnovator (VBI), announced the completion of Series D2 financing round over 100 million RMB. This financing round was jointly completed by V Capital, Shengze Investment, Sunbow Capital, VVB Fund and other institutions. The completion of the new financing round not only represents a significant affirmation of VivaVision's innovative achievements but also indicates positive expectations for its long-term development. The proceedings from this round will be used for the advancement of clinical trials of multiple ophthalmic innovative drugs, preclinical pipeline research and development, and the expansion of technology innovation platforms. The company is actively accelerating commercial cooperation on the mid-to-late-stage pipeline and pursuing forward-looking industrialization strategies. In addition, Dr.Erning Xia, Chief Technology Officer of VivaVision, recently participated in an exclusive interview with Haiwang Alliance. Furthermore, E-nitiate Biopharmaceuticals VivaVision's joint venture subsidiary, successfully completed QY211 Gel's first dose entry in Phase Ia healthy subjects. ABM Announces First Patient Dosed in Phase I Clinical Trial of MEK Inhibitor for Solid Tumor On May 4th, 2023, ABM Therapeutics, invested and incubated by Viva BioInnovator (VBI), announced that the first patient was successfully dosed with ABM-168, a novel small molecule MEK inhibitor, in the United States. This clinical trial will be conducted simultaneously at multiple clinical research centers in the United States. ABM-168 is a novel small molecule MEK inhibitor with high water solubility, cell and brain permeability. It has demonstrated anti-cancer efficacy in vitro in multiple cancer cell lines and in vivo in multiple xenograft animal models. Genhouse Bio H as Been S elected for the "Suzhou City List of Cultivated Potential Landmark Enterprises in the Biopharmaceutical Industry." Recently, Genhouse Bio, invested and incubated by Viva BioInnovator (VBI), is a clinical-stage biotech company focusing on the development of global next-generation anti-cancer therapeutics. Recently they have been selected for the "Suzhou City List of Cultivated Potential Landmark Enterprises in the Biopharmaceutical Industry." This recognition acknowledges Genhouse Bio's continuous innovation capability and research and development strength. Full Circles and FuseBio Awarded Innovation Awards at BCIC International Biomedical Innovation Competition Recently, the 2nd BCIC International Biomedical Innovation Competition, organized by the Boston Chinese Investment Association (BCIC),has been successfully held in Boston, USA. The event focuses on identifying high-quality early-stage biomedical projects and serves as a platform for effective communication and connection between startup companies and investors and aims to accelerate the global commercialization of technological achievements. This year's competition attracted 86 biomedical startups from around the world, and after six months of intense competition, 18 teams made it to the finals. Full Circles and FuseBio, both invested and incubated by Viva BioInnovator (VBI), achieved great success by winning the Innovation Award in this edition of the competition. Additionally, Full Circles secured the second position on the list. Technoderma Medicines Initiates TDM-105795 Androgenetic Alopecia Phase 2 Clinical Trial On April 17, 2023, PST, Technoderma Medicines, Inc. ("Technoderma"), invested and incubated by Viva BioInnovator (VBI), is a clinical stage biopharmaceutical company. Recently they were pleased to report that the Company has begun dosing patients in its Androgenetic Alopecia (AGA) Phase 2 clinical trial (NCT05802173) of topical TDM-105795 solution. Interview with Dr.Xiangdong Qu, the Founder of QureBio, in the Special Issue of Drug Hunter Recently, Dr.Xiangdong Qu, the founder of QureBio, invested and incubated by Viva BioInnovator (VBI), was jointly interviewed by the Drug Hunter and Healthcare Executive. Dr.Qu introduced the basic situation of the company, drugs in development, strategic thinking, milestone events and future strategic planning. About Triumvira Immunologics Triumvira Immunologics, Inc. ("Triumvira") is a clinical-stage company developing unique, non-gene edited, first-in-class targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with solid tumors. The company's proprietary T cell Antigen Coupler (TAC) technology is a robust and versatile platform that activates natural T cell functions differently from cell therapies such as CAR-T and engineered T cell receptor (TCR) therapies. Triumvira is headquartered in Austin, Texas with research facilities in Hamilton, Ontario, and South San Francisco, California. About AIxplorerBio AIxplorerBio is an AI-powered drug R&D biotech company. We focus on the discovery and development of new medicines for immunological and neurodegenerative diseases. We are also committed to creating a new AI-powered drug R&D paradigm to enable innovation, efficiency and precision in searching for better medicines. About VivaVision Biotech VivaVision is a clinical stage pharmaceutical company focused on best-in-class and first-in-class therapies for ocular diseases. VivaVision's current pipeline includes VVN001 for treating dry eye syndrome, VVN539 for the treatment for Glaucoma or Ocular Hypertension, and VVN461 for the treatment of non-infectious ocular inflammation of Uveitis. VivaVision is also engaged in discovery and development of novel therapies for the treatment of other anterior and posterior eye diseases. For more info, visit . About ABM Therapeutics ABM Therapeutics, a clinical-stage biopharmaceutical company with a mission to focus on small molecule research and development of novel drugs for the treatment of cancer, and on brain cancer and cancer metastases. ABM has been building a broad and robust proprietary pipeline to construct a brain medicine R&D platform. ABM's pipeline includes several programs in various stages of discovery and development, most of which have improved brain permeability to address the unmet needs of treating cancers and metastases in the brain. About Genhouse Genhouse Bio is a clinical-stage biotech company focusing on the development of global next-generation anti-cancer therapeutics, headquartered in the Suzhou Industry Park . The senior management team of Genhouse has multiple years of experience in new drug development, clinical research and corporate management. Genhouse has a clear focus on original innovation and overcoming those "undruggable" targets. About Full Circles Therapeutics Full Circles Therapeutics, formerly Stellate Biotherapeutics, is transforming viral free genome surgery platform to treat severe genetic disease and cancer worldwide. Their proprietory GATALYST platform enables insertion of any genetic sequence of any size at any location into human genome of disease relevant cells. With this disruptive technology, the company is dedicated to discover, develop, manufacture and commercialize novel curative genomic medicine for a brighter future of our patients and their families About Fuse Biotherapeutics, Inc. Fuse Biotherapeutics, Inc. is a biotechnology company that is dedicated to developing transformative immune modulating therapeutics for patients with cancer. Our therapeutic approach integrates the multiple steps of an immune response in a rational manner such that potent responses to danger are targeted without natural breaks in the system that spare healthy tissue. About Technoderma Medicines Technoderma Medicines, Inc. is a privately held clinical stage biopharmaceutical company. The Company was originally located in Jiaxing Xiuzhou Biomedicine Guoqian Park, China, and recently relocated to Chengdu Biomed Town, Chengdu, Sichuan Province, China. Its current core programs focus on development of innovative therapies for Androgenetic Alopecia, Atopic Dermatitis, Psoriasis and Lupus Erythematosus. Its "first-in-class" small molecule thyromimetic drug candidate TDM-105795 for Androgenetic Alopecia is currently in Phase 2a clinical testing. Technoderma's novel JAK1/TYK2 inhibitor TDM-180935 for Atopic Dermatitis is now in Phase 1 clinical testing. The pipeline targets dermatologic indications. About QureBio Ltd. QureBio Ltd. is a clinical-stage biopharmaceutical company focusing on innovative biopharmaceuticals for urgent and unmet clinical needs, such as the treatment of refractory cancers, inflammation and other serious disorders. Founded by experienced scientists from the relevant fields, QureBio Ltd. has built up a series of proprietary technologies for engineered bio-macromolecules, including innovative platforms for bi-specific and tri-specific antibodies. SOURCE Viva Biotech Holdings

SHANGHAI, Dec. 20, 2022 /PRNewswire/ -- QureBio Ltd., a clinical-stage biopharmaceutical company focusing on development of bispecific antibodies and other engineered Biopharmaceuticals for the treatment of cancer, inflammation, and other serious disorders, today announced that Phase Ⅰ Clinical Data of its Q-1802 program will be presented at ASCO Gastrointestinal Cancers Symposium (ASCO-GI) hold at the San Francisco and online on January 19–21, 2023. The abstract will be found in 2023 ASCO Gastrointestinal Cancers Symposium–Meeting Abstracts (#382) and a brief of the abstract information is shown as below: Interim results of a first-in-human phase 1 study of Q-1802, a CLDN18.2/PD-L1 bsABs in patients with relapsed or refractory solid tumors Authors: Yakun Wang1, Jifang Gong1, Yuping Sun2, Jian Zhang3, Yanqiao Zhang4 ,Shuqin ni2, Jie Hou5, Xiaohua Chen5, Yusheng Wang6, Qin Yu7, Xiangdong Qu8, Yejie Du8, Li Wei8, Tao Yu8, Lin Shen1 Q-1802 is a humanized bispecific antibody targets both the tumor -specific antigen CLDN18.2 and the immune checkpoint PD-L1 Q-1802 has excellent safety, tolerability Q-1802 has excellent anti-tumor activity in CLDN18.2 positive GI patients About Q-1802 Q-1802, a humanized bispecific antibody, is the first FDA-approved and the first enter clinical trial Claudin18.2/PD-L1 bispecific antibody，as well as the first to present clinical data at ASCO annual meeting. It recruits multiple immune mechanisms to kill tumor cells, offering a novel therapeutic opportunity for Claudin18.2 positive solid tumors. Q-1802 exhibits high affinity and selectivity, and patients with low or high expression of CLDN18.2 can benefit from it. The current clinical phase I data verify both superior anti-tumor activities and excellent safety profiles. The molecular design of Q-1802 is rational and effective, the production process is robust with high yield. About QureBio Ltd. QureBio Ltd. is a clinical-stage biopharmaceutical company focusing on innovative biopharmaceuticals for urgent and unmet clinical needs, such as the treatment of refractory cancers, inflammation and other serious disorders. Founded by experienced scientists from the relevant fields, QureBio Ltd. has built up a series of proprietary technologies for engineered bio-macromolecules, including innovative platforms for bi-specific and tri-specific antibodies. Founded in 2017 with seed capital from Viva Bio-Innovator, QureBio Ltd. has since received a series of funds from Jundu Investment, Watson Capital, Shenzhen Capital Group, New value Capital,Bocom Industrial Investment (Hangzhou) Equity Investment Partnership, Suzhou Oriza Holdings, Hangzhou CAPITAL GuoShun, Zhuhai Longmen Capital Management, Shanghai Pudong Kechuang Group, Shenzhen Lihe Hongxin Venture and Three Rivers Capital. QureBio Ltd. Has secured a Series-B funding of nearly 200 million CNY. QureBio Ltd. engages in collaboration with partners to develop novel therapeutics for unmet medical needsand has on-going cooperation with a series of industrial partners including BRL Medicine, Precision Scientific, and Hengrui Pharmaceuticals. Contact Us: Tel: +86 21-61622561 BD： Email: [email protected] Website: Address: Building 30, Lane 1000, Zhangheng Road, Pudong New Area, Shanghai Postal Code : 201203 SOURCE QureBio Ltd.