A review.It is found that there are many domestic production approvals in anti-emesis agents, and many domestic enterprises have been working on the production of this kind of generic drug by querying CFDA and FDA database, summarizing and analyzing the types of anti-emesis agents already on the international and domestic markets, the number of production license, sales and the applications of production registration in three years.Clin. medication is highly focused on 5-HT, receptor antagonist, the sales of which account for 98% market share of anti-emesis agents and the marketing trend has been steadily increasing.However, antiemetic market pattern will also usher in a new change and the pharmaceutical enterprises will be faced with new opportunities and challenges with NK-1 receptor antagonists as new anti-emesis being successfully marketed in recent years.Therefore, enterprises should pay attention to the risks resulting from the excessive imitation production while capturing the market.