Delving into the Latest Updates on Region Stockholm with Synapse

Disturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer's disease (AD). Lipid-lowering medications could interfere with neurodegenerative processes in AD through cholesterol metabolism or other mechanisms. The investigators aim to estimate the causal effect of statins on cognitive function measured by MMSE and to identify the mediating or modifying effect of cholesterol between statins and cognitive function in patients with Alzheimer's disease.

开始日期2025-01-01

申办/合作机构

Karolinska Institutet

[+1]

NCT06330779 / Not yet recruitingN/AIIT

Trauma-adapted Yoga in Child & Adolescent Psychiatry: A Multicenter Study.

The goal of this randomized clinical trial is to evaluate the efficacy of trauma-adapted yoga as a complementary intervention to care as usual in child and adolescents psychiatry clinics, in the population of adolescents with the diagnosis of ADHD and/or PTSD. We hypothesize that trauma-adapted yoga (TAY) is an effective non-pharmacological intervention for adolescent with ADHD and/or PTSD. Aims: (1) Validate the impact of TAY on the mental health & quality of life of adolescents with ADHD and/or PTSD. (2) Investigate the feasibility of online TAY for continued self-care. (3) Explore adolescents' experiences & parental perspectives on TAY in their treatment. (4) Explore healthcare professionals' experience on the integration of TAY into clinical practice.
Within and between group (yoga group vs waiting list) analyses will be performed.

开始日期2025-01-01

申办/合作机构

Region Stockholm

NCT06582225 / RecruitingN/AIIT

Internet-delivered Cognitive-behaviour Therapy for Obsessive- Compulsive Disorder in Children With Autism: A Randomised Controlled Trial

The purpose of this trial is to evaluate the clinical efficacy, the cost-effectiveness and the effect durability of a therapist-guided, internet-delivered cognitive-behavior therapy intervention for obsessive-compulsive disorder (OCD) in children and adolescents with autism. A process evaluation of the treatment will also be conducted.

开始日期2024-10-25

申办/合作机构

Karolinska Institutet

[+3]

100 项与 Region Stockholm 相关的临床结果

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0 项与 Region Stockholm 相关的专利（医药）

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1,898

项与 Region Stockholm 相关的文献（医药）

2024-09-03·Journal of Crohn's and Colitis

Spondyloarthritis in First-Degree Relatives and Spouses of Patients with Inflammatory Bowel Disease: A Nationwide Population-based Cohort Study from Sweden

Article

作者: Jess, Tine ; Shrestha, Sarita ; Askling, Johan ; Schoultz, Ida ; Olén, Ola ; Brand, Judith S ; Osooli, Mehdi ; Eriksson, Carl ; Montgomery, Scott ; Halfvarson, Jonas

AbstractBackground and AimsRegister-based research suggests a shared pathophysiology between inflammatory bowel disease [IBD] and spondyloarthritis [SpA], but the role of familial [genetic and environmental] factors in this shared susceptibility is largely unknown. We aimed to compare the risk of SpA in first-degree relatives [FDRs] and spouses of IBD patients with FDRs and spouses of matched, population-based, reference individuals.MethodsWe identified 147 080 FDRs and 25 945 spouses of patients with incident IBD [N = 39 203] during 2006–2016, and 1 453 429 FDRs and 258 098 spouses of matched reference individuals [N = 390 490], by linking nationwide Swedish registers and gastrointestinal biopsy data. Study participants were followed 1987–2017. Cox regression was used to estimate hazard ratios [HRs] of SpA.ResultsDuring follow-up, 2430 FDRs of IBD patients [6.5/10 000 person-years] and 17 761 FDRs of reference individuals [4.8/10 000 person-years] were diagnosed with SpA, corresponding to an HR of 1.35 [95% CI:1.29, 1.41]. In subgroup analyses, the increased risk of SpA was most pronounced in FDRs of Crohn’s disease patients [HR = 1.44; 95% CI:1.34,1.5 6] and of IBD patients aged <18 years at diagnosis [HR = 1.46; 95% CI: 1.27, 1.68]. IBD patients’ spouses also had a higher SpA rate than reference individuals’ spouses, but the difference was less pronounced [4.3 vs 3.5/10 000 person-years; HR = 1.22; 95% CI:1.09, 1.37]. No subgroup-specific risk pattern was identified among spouses.ConclusionsThe observed shared familial risks between IBD and SpA support shared genetic factors in their pathogenesis. However, spouses of IBD patients were also at increased risk for SpA, reflecting the influence of environmental exposures or similarities in health-seeking patterns.

2024-09-01·European Journal of Obstetrics & Gynecology and Reproductive Biology

On importance of consistent terminology and mutual understanding

Letter

作者: Savchenko, Julia ; Brismar Wendel, Sophia

2024-08-14·Journal of Crohn's and Colitis

The Epidemiology of Inflammatory Bowel Diseases During the COVID-19 Pandemic: Comparison of Two Nationwide Cohorts

Article

作者: Matz, Eran ; Loewenberg Weisband, Yiska ; Turner, Dan ; Ledderman, Natan ; Dotan, Iris ; Olén, Ola ; Ben-Tov, Amir ; Osooli, Mehdi ; Atia, Ohad ; Bryder, Nicklas ; Forss, Anders ; Mendelovici, Adi

AbstractBackgroundWe aimed to explore the epidemiology of inflammatory bowel diseases [IBD] in association with the COVID-19 pandemic in two countries with different lockdown policies.MethodsWe utilized nationwide IBD cohorts in Israel and Sweden to explore the incidence of IBD during the pandemic compared to 3 years prior [2017–2019]. We examined temporal trends through the presence of inflection points by Joinpoint regression analysis and reported average monthly percentage changes [AMPC].ResultsA total of 155 837 patients with IBD were included [Israel, 58 640; Sweden, 97 197]. The annual incidence of IBD was stable until 2019 in both countries but then decreased in Israel (AAPC −16.6% [95% confidence interval, CI, −19.9% to −10.0%]) and remained stable in Sweden (AAPC −3.5% [95% CI −11.6% to 3.7%]). When exploring the monthly incidence during the pandemic, in Israel the rate remained stable until November 2020 (AMPC 2.3% [95% CI −13.4% to 29.9%]) and then decreased sharply (AMPC –6.4% [95% CI –20.8% to 17.0%] until February 2021 and to −20.1% [95% CI –38.9% to –4.7%] from February 2021), while in Sweden, which had a less stringent lockdown policy, it decreased slightly until July 2020 (AMPC −3.3% [95% CI −21.6% to 20.3%]), but increased thereafter (AMPC 13.6% [95% CI –12.6% to 27.0%]). The change of incidence rate in Sweden occurred mainly in elderly-onset patients, the only population with significant restrictions during the pandemic.ConclusionThe incidence of IBD decreased during the pandemic in association with lockdowns, more so in Israel, which had more stringent policies. Future studies are needed to determine the long-term effect of the pandemic on IBD.

100 项与 Region Stockholm 相关的药物交易

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100 项与 Region Stockholm 相关的转化医学

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