Universal CAR-T cell technol. belongs to the universal T cell technol. based on gene editing in general CAR-T.It knocks out the signal receptor factor of T cell through gene editing, and produces CAR-T cell by using modified T cell from healthy volunteers; therefore it will not cause immune rejection such as graft vs. host disease(GvHD) and host vs. graft reaction(HvGR) after infusion.In animal experiments and early clin. trials, UCAR-T technol. shows significant anti-tumor effect, wide applicability and tremendous application potentials.In terms of industrialization, UCAR-T cell technol. is expected to solve the problems of high cost in designing and culturing autologous CAR-T preparations, of long preparation cycle, difficult quality control, insufficient cell quantity and expansion capacity, because of its unique features such as quality controllable, off-the-shelf, and easy for large-scale preparation, etc.This paper introduces the current research progress and existing problems of UCAR-T cells, and conducts a preliminary anal. of the existing problems, providing a reference for the fundamental research and clin. trials of UCAR-T cells.