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更新于：2026-10-05
Newish Technology (Beijing) Co., Ltd.
更新于：2026-10-05
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消化系统疾病
肿瘤
呼吸系统疾病
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CTR20254905
评价NWRD06在肝细胞癌根治术后患者中有效性和安全性的II期临床研究
NCT07324304
A Phase II Clinical Study to Evaluate the Efficacy and Safety of NWRD06 in Patients With Hepatocellular Carcinoma After Curative Resection.
NCT06741150
Safety and Efficacy Study of NWRD09 in HPV-16 Positive and HPV-16 Related Intraepithelial Neoplasia and Cervical Cancer Patients.
100 项与 诺未科技（北京）有限公司 相关的临床结果
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2022-09-21Stem cells translational medicine
Clinical Progress and Preclinical Insights Into Umbilical Cord Blood Transplantation Improvement
Review
作者: Su, XunCheng ; Xie, Huangfan ; Yao, Bing ; Sun, Zhongjie
Abstract:
The application of umbilical cord blood (UCB) as an important source of hematopoietic stem and progenitor cells (HSPCs) for hematopoietic reconstitution in the clinical context has steadily grown worldwide in the past 30 years. UCB has advantages that include rapid availability of donors, less strict HLA-matching demands, and low rates of graft-versus-host disease (GVHD) versus bone marrow (BM) and mobilized peripheral blood (PB). However, the limited number of HSPCs within a single UCB unit often leads to delayed hematopoietic engraftment, increased risk of transplant-related infection and mortality, and proneness to graft failure, thus hindering wide clinical application. Many strategies have been developed to improve UCB engraftment, most of which are based on 2 approaches: increasing the HSPC number ex vivo before transplantation and enhancing HSPC homing to the recipient BM niche after transplantation. Recently, several methods have shown promising progress in UCB engraftment improvement. Here, we review the current situations of UCB manipulation in preclinical and clinical settings and discuss challenges and future directions.
2022-06-22Stem cells translational medicine2区 · 医学
Transient Inhibition of the JNK Pathway Promotes Human Hematopoietic Stem Cell Quiescence and Engraftment
2区 · 医学
ArticleOA
作者: Guoxiong Tian ; Defang Liu ; Zhongjie Sun ; XunCheng Su ; Hailong Qi ; Huangfan Xie ; Miao Chen ; Ligong Chen ; Xiong Xiao
Abstract:
The widespread clinical application of cord blood (CB) for hematopoietic stem cell (HSC) transplantation is limited mainly by the inadequate number of hematopoietic stem and progenitor cells (HSPCs) in single CB units, which results in unsuccessful or delayed engraftment in recipients. The identification of agents to promote CB HSPC engraftment has significant therapeutic value. Here, we found that transient inhibition of the JNK pathway increased the HSC frequency in CB CD34+ cells to 13.46-fold. Mechanistic studies showed that inhibition of the JNK pathway upregulated the expression of quiescence-associated and stemness genes in HSCs, preventing HSCs from entering the cell cycle, increasing glucose uptake and accumulating reactive oxygen species (ROS). Importantly, transient inhibition of the JNK pathway during CB CD34+ cell collection also enhanced long-term HSC (LT-HSC) recovery and engraftment efficiency. Collectively, these findings suggest that transient inhibition of the JNK pathway could promote a quiescent state in HSCs by preventing cell cycle entry and metabolic activation, thus enhancing the HSC number and engraftment potential. Together, these findings improve the understanding of the regulatory mechanisms governing HSC quiescence and stemness and have the potential to improve HSC collection and transplantation.
2020-08-01Protein & cell1区 · 生物学
Memory T cells: strategies for optimizing tumor immunotherapy
1区 · 生物学
ReviewOA
作者: Sun, Zhongjie ; Liu, Qingjun ; Chen, Ligong
Abstract:
Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors. This review focuses on recent advances in efficacy against tumors, the origin, formation mechanisms of memory T cells, and the role of the gut microbiota in memory T cell formation. Furthermore, we summarize strategies to generate memory T cellsin(ex)vivothat, might be applicable in clinical practice.
2026-07-06
·搜狐新闻
2026-06-30
100 项与 诺未科技（北京）有限公司 相关的药物交易
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100 项与 诺未科技（北京）有限公司 相关的转化医学
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