Abstract:The number of patients with functional loss of bone and cartilage tissue has shown an increasing
trend. Insufficient or inappropriate conventional treatments applied for trauma, orthopedic
diseases, or other bone and cartilage-related disorders can lead to bone and cartilage damage. This
represents a worldwide public health issue and a significant economic burden. Advanced therapeutic
medicinal products (ATMPs) proposed promising alternative therapeutic modalities by application
of cell-based and tissue engineering approaches. Recently, several ATMPs have been developed
to promote bone and cartilage tissue regeneration. Fifteen ATMPs, two related to bone and 13
related to cartilage, have received regulatory approval and marketing authorization. However, four
ATMPs were withdrawn from the market for various reasons. However, ATMPs that are still on the
market have demonstrated positive results, their broad application faced limitations. The development
and standardization of methodologies will be a major challenge in the coming decades. Currently,
the number of ATMPs in clinical trials using mesenchymal stromal cells or chondrocytes indicates
a growing recognition that current ATMPs can be improved. Research on bone and cartilage
tissue regeneration continues to expand. Cell-based therapies are likely to be clinically supported by
the new ATMPs, innovative fabrication processes, and enhanced surgical approaches. In this study,
we highlighted the available ATMPs that have been used in bone and cartilage defects and discussed
their advantages and disadvantages in clinical applications.