The nutrient component of litchi rose wine and its antioxidant effect on D-galactose-induced aging mouse skin were detected. The 60 mice were randomly divided into normal group, D-galactose treatment group, vitamin C control group and low, medium and high dosage of litchi rose wine group, and the samples were analyzed after feeding for 12 wk. The results showed that litchi rose wine was rich in polyphenols, flavonoids, tannin and vitamin C, which were 0.43 g/L, 0.25 g/L, 0.12 g/L and 3.15 mg/100 mL, resp. There was no significant difference in body weight between groups after feeding 12 wk(P>0.05). The high-dose litchi rose wine(45.00 mL/kg body weight) feeding could significantly increase skin moisture,hydroxyproline and collagen content of aging mice, reduce malonaldehyde content, and glutathione peroxidase activity, and increase glutathione content,superoxide dismutase and catalase activity(P<0.05), maintain good redox homeostasis of the skin. Meanwhile, the skin oxidative damage and collagen breakdown could be inhibited by recovery expression of the genes related to antioxidant and collagen metabolism in aging mice skin.