别名 盘状结构域受体2、CD167 antigen-like family member B、CD167b + [12] |
简介 Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. |
作用机制 ABL 抑制剂 [+19] |
在研机构 |
原研机构 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2012-09-27 |
作用机制 DDR1拮抗剂 [+3] |
在研适应症 |
最高研发阶段临床1期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
作用机制 DDR1拮抗剂 [+5] |
在研机构 |
原研机构 |
在研适应症 |
最高研发阶段临床1期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2025-03-20 |
申办/合作机构 |
开始日期2024-11-01 |
申办/合作机构 Hope Medical Center [+1] |
开始日期2024-09-23 |
申办/合作机构 |