别名 过氧化物酶体增生物激活受体α、hPPAR、NR1C1 + [7] |
简介 Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. |
作用机制 PPARα激动剂 [+1] |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2024-06-10 |
作用机制 HMG-CoA reductase抑制剂 [+1] |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区 韩国 |
首次获批日期2019-04-03 |
靶点 |
作用机制 PPARα激动剂 |
原研机构 |
最高研发阶段批准上市 |
首次获批国家/地区 日本 |
首次获批日期2017-07-03 |
开始日期2024-11-01 |
申办/合作机构- |
开始日期2024-09-01 |
开始日期2024-09-01 |
申办/合作机构- |