更新于：2024-11-01

BDCA2 x GR

更新于：2024-11-01

基本信息

关联

项与 BDCA2 x GR 相关的药物

DB-2304

靶点

BDCA2 x GR

作用机制

BDCA2抑制剂 [+1]

在研机构

映恩生物制药（苏州）有限公司 [+1]

原研机构

映恩生物制药（苏州）有限公司

在研适应症

自身免疫性疾病

非在研适应症-

最高研发阶段临床1期

首次获批国家/地区-

首次获批日期1800-01-20

项与 BDCA2 x GR 相关的临床试验

NCT06625671 / Not yet recruiting临床1期

A Randomized, Double-Blind, Placebo- and Positive-Controlled, Single Ascending Dose Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DB-2304 Injection in Healthy Adult Participants

A Randomized, Double-Blind, Placebo- and Positive-Controlled, Single Ascending Dose Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of DB-2304 Injection in Healthy

开始日期2024-10-04

申办/合作机构

DualityBio Inc.初创企业

100 项与 BDCA2 x GR 相关的临床结果

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100 项与 BDCA2 x GR 相关的转化医学

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0 项与 BDCA2 x GR 相关的专利（医药）

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项与 BDCA2 x GR 相关的文献（医药）

2021-03-09·Blood Advances2区 · 医学

Transcriptomic and genomic heterogeneity in blastic plasmacytoid dendritic cell neoplasms: from ontogeny to oncogenesis

2区 · 医学

Article

作者: Ferrand, Christophe ; Jardin, Fabrice ; Renosi, Florian ; Preudhomme, Claude ; Saas, Philippe ; Asnafi, Vahid ; Colinge, Jacques ; Petrella, Tony ; Soret, Lou ; Angelot-Delettre, Fanny ; Callanan, Mary ; Adotévi, Olivier ; Harrivel, Véronique ; Macintyre, Elizabeth ; Bouyer, Sabrina ; Saussoy, Pascale ; Daguindau, Etienne ; Fuseau, Pascal ; Garnache-Ottou, Francine ; Viailly, Pierre-Julien ; Giguelay, Ambre ; Feuillard, Jean ; Roumier, Christophe ; Biichle, Sabeha ; Geffroy, Sandrine ; Deconinck, Eric ; Salaun, Véronique ; Roggy, Anne ; Cheok, Meyling

AbstractOncogenesis and ontogeny of blastic plasmacytoid dendritic cell neoplasm (BPDCN) remain uncertain, between canonical plasmacytoid dendritic cells (pDCs) and AXL+ SIGLEC6+ DCs (AS-DCs). We compared 12 BPDCN to 164 acute leukemia by Affymetrix HG-U133 Plus 2.0 arrays: BPDCN were closer to B-cell acute lymphoblastic leukemia (ALL), with enrichment in pDC, B-cell signatures, vesicular transport, deubiquitination pathways, and AS-DC signatures, but only in some cases. Importantly, 1 T-cell ALL clustered with BPDCN, with compatible morphology, immunophenotype (cCD3+ sCD3− CD123+ cTCL1+ CD304+), and genetics. Many oncogenetic pathways are deregulated in BPDCN compared with normal pDC, such as cell-cycle kinases, and importantly, the transcription factor SOX4, involved in B ontogeny, pDC ontogeny, and cancer cell invasion. High-throughput sequencing (HaloPlex) showed myeloid mutations (TET2, 62%; ASXL1, 46%; ZRSR2, 31%) associated with lymphoid mutations (IKZF1), whereas single-nucleotide polymorphism (SNP) array (Affymetrix SNP array 6.0) revealed frequent losses (mean: 9 per patient) involving key hematological oncogenes (RB1, IKZF1/2/3, ETV6, NR3C1, CDKN2A/B, TP53) and immune response genes (IFNGR, TGFB, CLEC4C, IFNA cluster). Various markers suggest an AS-DC origin, but not in all patients, and some of these abnormalities are related to the leukemogenesis process, such as the 9p deletion, leading to decreased expression of genes encoding type I interferons. In addition, the AS-DC profile is only found in a subgroup of patients. Overall, the cellular ontogenic origin of BPDCN remains to be characterized, and these results highlight the heterogeneity of BPDCN, with a risk of a diagnostic trap.

Genes3区 · 生物学

Novel Insights into Antiviral Gene Regulation of Red Swamp Crayfish, Procambarus clarkii, Infected with White Spot Syndrome Virus

3区 · 生物学

ArticleOA

作者: Zhang, Long ; Shi, Linlin ; Yi, Shaokui ; Li, Yanhe

White spot syndrome virus (WSSV), one of the major pathogens of Procambarus clarkii, has caused severe disruption to the aquaculture industry of P. clarkii in China. To reveal the gene regulatory mechanisms underlying WSSV infection, a comparative transcriptome analysis was performed among WSSV-infected susceptible individuals (GS), viral resistant individuals (GR), and a non-infected control group (GC). A total of 61,349 unigenes were assembled from nine libraries. Subsequently, 515 and 1033 unigenes exhibited significant differential expression in sensitive and resistant crayfish individuals compared to the control group (GC). Many differentially expressed genes (e.g., C-type lectin 4, Peroxinectin, Prophenoloxidase, and Serine/threonine-protein kinase) observed in GR and GS play critical roles in pathogen recognition and viral defense reactions after WSSV infection. Importantly, the glycosaminoglycan biosynthesis-chondroitin sulfate/dermatan sulfate pathway was identified to play critical roles in defense to WSSV infection for resistant crayfish individuals by upregulating the chondroitin sulfate related genes for the synthesis of WSSV-sensitive, functional chondroitin sulfate chains containing E units. Numerous genes and the key pathways identified between resistant and susceptible P. clarkii individuals provide valuable insights regarding antiviral response mechanisms of decapoda species and may help to improve the selective breeding of P. clarkii WSSV-resistance.