别名 神经氨酸酶 |
简介 Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication. |
作用机制 neuraminidase抑制剂 |
非在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 日本 |
首次获批日期2010-09-10 |
作用机制 neuraminidase抑制剂 |
在研机构 |
最高研发阶段批准上市 |
首次获批国家/地区 日本 |
首次获批日期2010-01-13 |
作用机制 neuraminidase抑制剂 |
在研机构 |
非在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 瑞士 |
首次获批日期1999-09-21 |
开始日期2024-03-15 |
申办/合作机构 |
开始日期2024-03-15 |
申办/合作机构 |
开始日期2024-01-19 |
申办/合作机构 |