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Topline GSBR-1290 Phase 2a 12-week obesity data, as well as data from formulation bridging and titration optimization study, on track for latter half of the second quarter 2024 Phase 2b study in obesity expected to begin as planned in the fourth quarter 2024 Year-end cash balance of $467.3 million expected to fund operations and key clinical milestones through 2026 SAN FRANCISCO, March 08, 2024 (GLOBE NEWSWIRE) -- Structure Therapeutics Inc. (NASDAQ: GPCR), a clinical-stage global biopharmaceutical company developing novel oral small molecule therapeutics for metabolic and cardiopulmonary diseases, today reported financial results for the fourth quarter and full year ended December 31, 2023, and highlighted recent corporate achievements. “In 2023 we demonstrated clear proof-of-concept with our lead GLP-1 receptor agonist, GSBR-1290, for obesity and type 2 diabetes. As a differentiated oral small molecule we have the scalability and manufacturing advantages to potentially meet the significant unmet need currently observed in the GLP-1 space,” said Raymond Stevens, Ph.D., Founder and CEO of Structure Therapeutics. “With a year-end cash balance of $467.3 million providing runway through the end of 2026, we are well-positioned to initiate and complete our Phase 2b trials for GSBR-1290 and accelerate development of our oral small molecule programs targeting amylin, GIP, and apelin receptors.” Recent Highlights and Upcoming Milestones GSBR-1290 for Type 2 Diabetes Mellitus (T2DM) and Obesity In December 2023, the Company reported clinically meaningful data from the Phase 2a study in T2DM demonstrating significant reductions in hemoglobin A1c (HbA1c) and weight at 12 weeks. Interim Phase 2a data from the obesity cohort demonstrated significant reduction in weight at 8 weeks. Across both cohorts, GSBR-1290 was generally well-tolerated with no treatment-related serious adverse events over 12 weeks and low study discontinuation rates due to adverse events related to study drug (2.8% in T2DM and 0% in obesity).Topline data from the obesity cohort of the Phase 2a study, including full 12-week efficacy data for 40 participants and safety and tolerability for all 64 participants. This study is fully enrolled and data are expected in the latter half of the second quarter of 2024.In preparation for later stage clinical trials, a formulation bridging and titration optimization study to evaluate capsule versus tablet pharmacokinetics (PK) and explore different titration regimens of GSBR-1290 is ongoing. This study is fully enrolled and data are expected in the latter half of the second quarter of 2024.The Company plans to initiate a global Phase 2b obesity study of GSBR-1290 in the fourth quarter of 2024.The Company plans to initiate a Phase 2 study in T2DM in the second half of 2024. GLP-1R Combination Programs: Amylin, GIPR, Apelin (APJR) Oral Small Molecule Amylin Program: The Company is developing amylin agonists for use either alone or in combination with GLP-1R agonists to treat obesity and associated diseases, and expects to select a development candidate in the second half of 2024.Oral Small Molecule GIPR Program: The Company is developing a GIPR selective agonist and GLP‑1R/GIPR combinations to treat obesity and associated diseases, and expects to select a development candidate in the first half of 2025.Oral Small Molecule Apelin Receptor (APJR) Program: The Company is evaluating its Phase 2 ready ANPA-0073, a biased agonist targeting APJR used in combination with weight loss medicines, for selective or muscle-sparing weight loss. ANPA-0073 is also being evaluated for idiopathic pulmonary fibrosis (IPF). The Company has completed a Phase 1 single-ascending and multiple-ascending dose study, in which ANPA-0073 was generally well-tolerated with no serious adverse event reported. LPA1R Program for Idiopathic Pulmonary Fibrosis (IPF) The Company is developing LTSE-2578, an oral small molecule antagonist that targets lysophosphatidic acid 1 receptor (LPA1R). Preclinical studies have demonstrated substantial anti-fibrotic activity in mouse models of fibrotic lung disease, and the Company expects to initiate a first-in-human study of LTSE-2578 in the second quarter of 2024. Corporate In 2023, the Company raised approximately $485.0 million of equity capital: $185.0 million in gross proceeds from the initial public offering in February, and $300.0 million in gross proceeds from the private placement equity financing in October. Fourth Quarter and Full Year 2023 Financial Highlights Cash Position: Cash, cash equivalents and short-term investments totaled $467.3 million at December 31, 2023. The Company expects its current cash, cash equivalents and short-term investments to fund operations and expected key clinical milestones through at least 2026. R&D Expenses: Research and development (R&D) expenses for the fourth quarter of 2023 were $20.0 million, as compared to $8.4 million for the same period in 2022. For the year ended December 31, 2023, R&D expenses were $70.1 million, as compared to $36.2 million for the full year 2022. The increase was primarily due to the advancement of the Company’s GLP-1R franchise and other research programs, clinical study activities and increases related to employee expenses, primarily due to an increase in personnel. G&A Expenses: General and administrative (G&A) expenses for the fourth quarter of 2023 were $11.0 million, as compared to $4.6 million for the same period in 2022. For the year ended December 31, 2023, G&A expenses were $32.7 million, as compared to $16.4 million for the full year 2022. The increase was primarily due to increases in professional services and employee related expenses as the Company expanded its infrastructure to drive and support the growth in its operations as a publicly-traded company. Net Loss: Net loss for the fourth quarter of 2023 totaled $24.5, with non-cash stock-based compensation expense of $2.1 million, compared to $11.9 million for the fourth quarter of 2022 with non-cash stock-based compensation expense of $0.6 million. For the year ended December 31, 2023, net loss totaled $89.6 million, with non-cash stock-based compensation expense of $8.2 million, compared to $51.3 million for the full year 2022 with non-cash stock-based compensation expense of $2.5 million. About Structure TherapeuticsStructure Therapeutics is a leading clinical-stage biopharmaceutical company focused on discovering and developing innovative oral treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Utilizing its next generation structure-based drug discovery platform, the Company has established a scientifically-driven, GPCR-targeted pipeline, featuring two wholly-owned proprietary clinical-stage small molecule compounds designed to surpass the limitations of traditional biologic and peptide therapies and be accessible to more patients around the world. For additional information, please visit www.structuretx.com. Forward Looking Statements This press release contains “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact are statements that could be deemed forward-looking statements, including, without limitation, statements concerning the Company’s future plans and prospects, the Company’s anticipated cash runway, the clinical update from Structure’s Phase 2a study of GSBR-1290 in patients with T2DM and obesity, any expectations regarding the safety, efficacy or tolerability of GSBR-1290 and other candidates under development, the ability of GSBR-1290 to treat T2DM, obesity or related indications, the planned initiation and study design of Structure’s Phase 2b studies for GSBR-1290 in patients with T2DM and obesity and the timing thereof, and first-in-human study of LTSE-2578 and the timing thereof, respectively, the selection of a development candidate for the Company’s amylin receptor agonist program and GLP-1R/GIPR program, the planned timing of the Company’s data results and continued development of GSBR-1290, amylin and next generation GLP-1R/GIPR combination candidates and expectations regarding an oral development candidate targeting GLP-1R. In addition, when or if used in this press release, the words “may,” “could,” “should,” “anticipate,” “believe,” “estimate,” “expect,” “intend,” “plan,” “predict” and similar expressions and their variants, as they relate to the Company may identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Although the Company believes the expectations reflected in such forward-looking statements are reasonable, the Company can give no assurance that such expectations will prove to be correct. Readers are cautioned that actual results, levels of activity, safety, performance or events and circumstances could differ materially from those expressed or implied in the Company’s forward-looking statements due to a variety of risks and uncertainties, which include, without limitation, risks and uncertainties related to the preliminary nature of the results due to length of the study and sample size, the risks that unblinded data is not consistent with blinded data, the Company’s ability to advance GSBR-1290, LTSE-2578, ANPA-0073 and its other therapeutic candidates, obtain regulatory approval of and ultimately commercialize the Company’s therapeutic candidates, the timing and results of preclinical and clinical trials, the impact of any data collection omissions at any of our clinical sites, the Company’s ability to fund development activities and achieve development goals, the impact of any global pandemics, inflation, supply chain issues, rising interest rates and future bank failures on the Company’s business, its ability to protect its intellectual property and other risks and uncertainties described in the Company’s filings with the Securities and Exchange Commission (SEC), including the Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2023, as filed with the SEC on November 17, 2023, and future reports the Company may file with the SEC from time to time. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management’s assumptions and estimates as of such date. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law. STRUCTURE THERAPEUTICS INC.Condensed Consolidated Statements of Operations(unaudited)(In thousands, except per share amounts) THREE MONTHS ENDED YEAR ENDED DECEMBER 31, DECEMBER 31, 2023 2022 2023 2022Operating expenses: Research and development $20,042 $8,360 $70,103 $36,193 General and administrative 10,952 4,596 32,672 16,368 Total operating expenses 30,994 12,956 102,775 52,561 Loss from operations (30,994) (12,956) (102,775) (52,561)Interest and other income (expense), net 6,179 901 13,391 1,257 Loss before provision for income taxes (24,815) (12,055) (89,384) (51,304)Provision for income taxes (312) (180) 236 17 Net loss $(24,503) $(11,875) $(89,620) $(51,321) STRUCTURE THERAPEUTICS INC.Condensed Consolidated Balance Sheet Data(unaudited)(In thousands) DECEMBER 31, 2023 2022Assets Current assets: Cash, cash equivalents and short-term investments $467,323 $90,841 Prepaid expenses and other current assets 6,285 2,248 Total current assets 473,608 93,089 Property and equipment, net 3,228 1,031 Operating right-of-use assets 5,136 262 Other non-current assets 45 3,463 Total assets $482,017 $97,845 Liabilities, redeemable convertible preferred shares and shareholders’ equity (deficit) Current liabilities: Accounts payable $4,742 $6,009 Accrued expenses and other current liabilities 18,558 6,741 Operating lease liabilities, current portion 1,440 260 Total current liabilities 24,740 13,010 Operating lease liabilities, net of current portion 4,013 — Other non-current liabilities 298 — Total liabilities 29,051 13,010 Redeemable convertible preferred shares issuable in series — 199,975 Total shareholders’ equity (deficit) 452,966 (115,140)Total liabilities, redeemable convertible preferred shares and shareholders’ equity (deficit) $482,017 $97,845 Investors:Danielle KeatleyStructure Therapeutics Inc.ir@structuretx.com Media:Dan Budwick1ABDan@1abmedia.com

2024年才走过近两个月的时间，抗衰领域已诞生一笔1.7亿美元的融资。获得融资的企业名为BioAge Labs（下文简称BioAge），是一家成立于2015年的抗衰明星公司，致力于利用AI技术开发治疗衰老和年龄相关性疾病、延长人类健康寿命的创新药物。而在该公司宣布完成D轮融资后不久，其还于近日宣布将于2024年中期启动与礼来合作的一项2期临床试验，以评估BioAge的Apelin受体（APJ）激动剂Azelaprag（BGE-105）与礼来的GLP-1R/GIPR双靶点激动剂 Tirzepatide（替尔泊肽）的联合疗法在治疗肥胖症中的疗效。并且，动脉网了解到，在试验过程中，BioAge也将在遵守相关法律法规的基础上收集受试者的衰老相关生物标志物信息，以此助力BioAge其他处于临床早期衰老管线的研发。截至目前，BioAge针对衰老问题的研究集中在3个方向，分别是代谢和肌肉衰老、大脑衰老、免疫衰老。同时，依托独有的AI药物发现平台，BioAge还拥有多条在研管线，适应症包括肥胖症、神经炎症、急性肌肉萎缩等与衰老相关的疾病。 明星团队支撑，获近3亿美元融资成立至今，BioAge已完成5轮融资，共募资近3亿美元，Andreessen Horowitz、Pear Ventures以及AME Cloud Ventures等投资者更是多轮押注，并且先后与安进和礼来达成合作。BioAge融资过程  数据来源：crunchbase官网，动脉网制图BioAge备受明星资本青睐和知名企业看重的背后，是一支从默克、罗氏、英矽智能等企业的核心团队作支撑。其联合创始人兼首席执行官Kristen Fortney博士是一位在生物信息学领域拥有超10年研究经验的创业者。她不仅获得了多伦多大学生物信息学博士学位并在斯坦福大学接受博士后培训，还成为了两个知名衰老研究机构——American Federation for Aging Research（美国老龄化研究联合会）和Ellison Medical Foundation（埃里森医学基金会）的研究员，发表论文共计18篇，研究领域包括计算药物发现、衰老生物标志物和延长人类寿命的遗传学等。此外，Kristen Fortney曾担任Insilico Medicine、Humanity、Retro Biosciences、Known Medicine等药物研发公司的顾问。值得一提的是，BioAge识别和靶向驱动衰老的分子途径的数据驱动方法正是由其主导开发。并且，与创始人相似的是，BioAge的核心团队成员也具有衰老研究和系统生物学的深厚背景——其首席运营官Eric Morgen在靶点发现、衰老、药物基因组学等领域发表了20余篇论文；担任公司首席营销官兼执行副总裁一职的Paul Rubin博士曾在MiRagen、Glaxo-Wellcome、Abbott等生物制药公司担任要职，并将10多种产品从临床开发推动至获批，其中包括第一个获批用于临床治疗哮喘的5-脂氧合酶抑制剂齐留通（Zileuton）。同时，BioAge还吸引了Peng Leong博士出任首席商务官兼脑衰老治疗领域负责人一职，Peng Leong博士此前曾在CIBC World Markets和Piper Jaffray从事医疗投资银行业务，并曾担任默克的医学业务开发主管以及Kazia Therapeutics的首席品牌官。此外，BioAge的科学顾问团队也为公司的发展保驾护航，主要成员包括抗血小板药物Aggrastat®的主要研发人George Hartman博士，曾负责罗氏抗病毒药物临床开发的Klaus Klumpp博士，以及曾在Twitter、Google、麦肯锡公司担任企业战略副总裁、产品经理的Elad Gil博士等，他们的加入为公司的核心管线推进提供了研发动力。独有AI平台：基于6550万+数据点，每年评估约20种衰老途径2019年，BioAge宣布完成2300万美元B轮融资，该轮资金推动了公司搭建基于AI技术的高通量目标识别平台，即AI药物发现平台。该平台能够在海量的数据中搜索并确定影响人类寿命的关键生物途径和药物靶点，并通过高通量生物验证、最终将潜在靶点推进临床开发阶段。但BioAge并不止步于简单的检索验证，公司期望通过集成更多的AI技术和数据库信息，将原有平台升级为一个由AI驱动，可利用大量生物数据来发现、验证更广泛的衰老途径和药物靶点的技术平台。为此，在2022年BioAge宣布与Age Labs达成合作协议，获得了对AgeLabs数据库的独家访问权，BioAge能够使用Nord-Trøndelag健康研究（HUNT）生物库样本和健康记录来识别、开发和商业化针对衰老疾病的药物靶点。值得关注的是，HUNT自1995年至今纵向收集的生物样本适用于表观遗传学、蛋白质组学和代谢组学分析。在此基础上，BioAge的AI药物发现平台可深入分析来自纵向的生物样本，识别影响健康长寿和与年龄相关性疾病的蛋白质、代谢物或分子机制，而后快速确定衰老途径中的关键靶点。经过多年创新发展，BioAge的平台目前建立在一个拥有45年长度的纵向样本和健康记录的数据库上，拥有150万多个临床数据点、6400万多个分子数据点共6550万多个数据点，每年可评估约20种衰老途径。其中，该平台的最大优势是根据纵向数据跟踪患者衰老结果，从而确定导致衰老发生的新机制和驱动因素，并在已知和新型衰老生物学的交叉点上识别全新靶点。临床前试验显示小鼠体重减轻2倍，BioAge拳头产品可实现减脂不减肌Azelaprag正是BioAge通过AI平台发现并推进研发的在研管线。2021年，BioAge与安进签订了一项全球独家许可协议，获得了该药物的开发和商业化的权利。经过2年多研发推进，Azelaprag已成为公司目前在代谢和肌肉衰老领域的重要资产Azelaprag是一款可口服或静脉注射的APJ激动剂，可用于治疗肌肉萎缩并通过提高Apelin信号活性来恢复肌肉力量和功能。其中，Apelin是一种在运动后释放的“运动因子”多肽，其内生受体APJ是一种G蛋白偶联受体，在体内多种器官细胞上表达，主要包括中枢神经系统跟心血管系统，并通过与骨骼肌、心脏和中枢神经系统的相互作用调节新陈代谢，促进肌肉再生。研究显示，当人体开始衰老时，其骨骼和肌肉质量会逐渐减少，骨折、虚弱等风险也相应增加，比如，多发于老年人群体的肌肉萎缩，对于他们来说，肌肉衰老会导致力量、活动能力和功能丧失，进而导致与年龄相关的疾病和死亡发生率的增加。数据显示，功能性肌肉减少症或与年龄相关的肌肉骨骼变化影响7%的70岁以上的老年人1。BioAge的研究也证明，人体的总体Apelin水平会随着衰老过程而逐渐下降，而Apelin水平较高的人具有更强的身体功能和更长的寿命。其临床前研究显示，Azelaprag与替尔泊肽联合使用可增加受试小鼠整体体重减轻效果，与单独使用替尔泊肽相比，Azelaprag组的受试小鼠体重减轻了2倍，并且能够将身体成分和肌肉功能恢复到可控水平。在Azelaprag的1b期临床试验中，数据显示，21名65岁及以上的健康受试者在接受Azelaprag或安慰剂输注并严格卧床休息10天后，与安慰剂相比，Azelaprag在肌肉大小、质量和蛋白质合成方面产生了统计学上的显著改善，且并未产生严重副作用，具有良好的安全性和耐受性。基于积极的临床试验数据，BioAge将与礼来合作开展一项2期临床试验，评估Azelaprag是否可以增强GLP-1药物所实现的减肥效果。作为一款防止肌肉衰老的药物，Azelaprag与GLP-1药物联合用药，将有可能减轻该类药物引起的胃肠道问题和肌肉质量损失等副作用，促进实现更健康的减肥效果，最终通过治疗肥胖有效预防或延缓多种衰老疾病进展、延长患者的健康寿命。 布局多条在研管线，探索抗衰无限可能性在AI平台的支持下，BioAge针对衰老领域中的不同适应症布局了多条在研管线，除了前文提到的核心管线Azelaprag外，还包括BGE-100。BioAge在研管线  图源：BioAge官网BGE-100是一种NLRP3（NOD样受体热蛋白结构域相关蛋白3）抑制剂，被开发用于治疗由神经炎症引起的神经退行性疾病，帮助延长患者寿命。目前，BGE-100处于临床前毒理学研究阶段，预计将于2024年年中进入临床试验。值得关注的是，BioAge还曾布局了其他两款衰老管线——BGE-175和BGE-117。其中，BGE-175是一种前列腺素D2（PGD2）DP1 受体的抑制剂，被开发用于治疗因免疫老化导致的多种疾病，实现修复老化的免疫系统的目的。BGE-117是一种缺氧诱导因子-脯氨酰羟化酶（HIF-PH）抑制剂，被开发用于治疗多种衰老疾病，从而提高老年人寿命。不过，BioAge先后在2021年放弃了BGE-175和BGE-117两项资产，将重点转至BGE-100和Azelaprag，并逐步将赛道从衰老覆盖至减肥领域。对此，Kristen Fortney表示，对代谢疾病领域的关注将同时促进公司衰老领域的业务发展，最终将促进解决衰老以及与年龄相关疾病治疗的问题。尽管创新药物研发这条路还很长，但是在未来，BioAge的在研药物也许会成为患者摆脱疾病困扰、延长健康寿命的希望。参考资料：1. Amarya S, Singh K, Sabharwal M. Ageing process and physiological changes[M]//Gerontology. IntechOpen, 2018.文|冯汝梅微信|echo822207添加时请注明：姓名-公司-职位网站、公众号等转载请联系授权：Rekkiiie近期推荐声明：动脉网所刊载内容之知识产权为动脉网及相关权利人专属所有或持有。未经许可，禁止进行转载、摘编、复制及建立镜像等任何使用。动脉网，未来医疗服务平台

引言Apelin（爱帕琳肽）是心血管稳态的关键激素，可激活Apelin受体(APLNR)，被认为是心血管疾病的一个有前景的治疗靶点。然而，通过β-抑制素途径产生的不良反应限制了其药理应用。2024年2月29日，浙江大学张岩及北京大学张岩共同通讯在Cell 在线发表题为“Structure-based design of non-hypertrophic apelin receptor modulator”的研究论文，该研究报告了与三种具有不同信号谱的激动剂结合的APLNR-Gi1复合物的冷冻电镜(cryo-EM)结构。结合功能分析，作者确定了APLNR中的“双热点”是信号偏倚的关键决定因素，指导了两种独家G蛋白偏倚激动剂WN353和WN561的合理设计。WN353-和WN561刺激的APLNR-G蛋白复合物的cryo-EM结构进一步证实了所设计的配体具有所需的姿态。病理生理实验证明，与已建立的APLNR激动剂相比，WN561对心脏肥厚的治疗效果更好，不良反应更少。该研究设计的APLNR调节剂可能促进下一代心血管药物的开发。心肌肥大的特征是心肌质量增加，是对病理性刺激(如高血压和瓣膜疾病)的适应性反应。虽然最初是有益的，但持续的肥厚可能导致疾病进一步进展并加剧心力衰竭，心力衰竭是世界上最常见和最致命的疾病之一，并且仍然无法治愈。抑制或逆转心肌肥厚和随后的不适应心肌重构是心力衰竭的主要治疗方法。心肌细胞肥大可由多种内在和外在刺激触发，包括机械应力和激素，这些刺激可通过一系列细胞膜受体被心肌细胞识别G蛋白偶联受体(GPCRs)，在启动肥厚信号通路和调节健康和患病状态下的心脏功能方面至关重要。广泛的GPCR拮抗剂已用于治疗心力衰竭，包括靶向β-肾上腺素能受体、血管紧张素II受体和醛固酮受体的拮抗剂。由于疗效不足和不良反应，只有少数治疗心血管疾病，特别是治疗心力衰竭的药物有改善生活质量、身体功能或症状的指征。因此，有必要确定新的治疗靶点和策略来对抗心力衰竭。Apelin受体APJ是一种典型的A类GPCR，在心血管系统中起着至关重要的作用。APLNR的多种生理作用包括促进心脏收缩力、增加左室卒中容量、血管舒张、促进利尿、降低体血压。apelin/APLNR系统也参与心血管疾病的病理生理，如心力衰竭和肺动脉高压，使其成为一个有希望的治疗靶点。Apelin是APLNR的内源性配体，作为平衡激动剂激活APLNR的G蛋白和β-阻滞蛋白途径。有研究提出，apelin诱导的心脏保护作用主要归因于APLNR的Gi信号传导，而APLNR的β-骤停素途径导致有害的心脏肥厚。因此，人们对开发G蛋白偏倚的APLNR激动剂作为治疗心力衰竭的潜在药物越来越感兴趣。已经发现了几种部分G蛋白偏倚的APLNR激动剂，尽管与apelin相比G蛋白活性降低，但在大鼠和人类中均表现出优越的心血管作用。特别是，MM07是一种G蛋白偏倚肽激动剂，通过用半胱氨酸取代apelin中的位置1和6而产生二硫键，而CMF-019是一种G蛋白偏倚的APLNR小分子激动剂。然而，尽管这些配体的低但保留的β-阻滞蛋白信号仍然是其安全临床应用的主要障碍，强调迫切需要开发真正的G蛋白偏向激动剂，在保持完整的G蛋白信号的同时消除β-阻滞蛋白信号活性。模式图（Credit: Cell）该研究首先用三种激动剂([Pyr1]-apelin-13(简称apelin)， MM07和CMF-019)解析了aplnn-Gi1复合物的高分辨率冷冻电镜(cryo-EM)结构。这些结构揭示了不同的配体结合特性，以及强调APLNR偏置信号的分子机制。基于这些发现，作者设计了G蛋白偏向激动剂WN353和WN561，它们几乎消除了β-阻滞蛋白活性，同时保持了G蛋白信号传导能力。解决WN353-和wn561结合的aplnn-Gi1复合物的两个冷冻电镜结构使得能够了解APLNR中偏倚信号传导的机制。体外和体内病理生理研究证实，所鉴定的G蛋白偏倚激动剂WN561在促进G蛋白信号传导心脏保护功能的同时，减少β-阻滞蛋白活性潜在的肥厚不良反应，具有良好的应用前景。原文链接https://www.cell.com/cell/abstract/S0092-8674(24)00125-9责编|探索君排版|探索君文章来源|“iNature”End往期精选围观一文读透细胞死亡(Cell Death) | 24年Cell重磅综述（长文收藏版）热文Nature | 破除传统：为何我们需要重新思考肿瘤的命名方式热文Nature | 2024年值得关注的七项技术热文Nature | 自身免疫性疾病能被治愈吗？科学家们终于看到了希望热文Nature | 癌症与神经系统的致命舞蹈