更新于：2024-11-01

DENV NS5 polymerase

更新于：2024-11-01

基本信息

别名-

简介-

关联

项与 DENV NS5 polymerase 相关的药物

Q63

靶点

DENV NS5 polymerase

作用机制

DENV NS5 polymerase抑制剂

在研机构

南方医科大学

原研机构

南方医科大学

在研适应症

登革热

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

NITD-434

靶点

DENV NS5 polymerase x RdRp

作用机制

DENV NS5 polymerase抑制剂 [+1]

在研机构

Novartis Institutes for Biomedical Research, Inc.

原研机构

Novartis Institutes for Biomedical Research, Inc.

在研适应症

登革热

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

NITD-640

靶点

DENV NS5 polymerase

作用机制

DENV NS5 polymerase抑制剂

在研机构

Novartis Institutes for Biomedical Research, Inc.

原研机构

Novartis Institutes for Biomedical Research, Inc.

在研适应症

登革热

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 DENV NS5 polymerase 相关的临床结果

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100 项与 DENV NS5 polymerase 相关的转化医学

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0 项与 DENV NS5 polymerase 相关的专利（医药）

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181

项与 DENV NS5 polymerase 相关的文献（医药）

2024-12-31·Emerging Microbes & Infections

Epidemiology and global spread of emerging tick-borne Alongshan virus

Review

作者: Gömer, André ; Janshoff, Saskia ; Lang, Arthur ; Steinmann, Eike ; Steinmann, Joerg

The emergence and spread of novel viral pathogens is a major threat to human health, particularly in the context of climate and human-induced change in land use. Alongshan virus (ALSV) is a tick-borne virus associated with human disease, which was first identified in northeast China. More recently, several studies reported the emergence of ALSV in mammalian and arthropod hosts in multiple different countries outside of Asia, and the first viral genome sequencing data has become available. ALSV is a member of the Jingmenvirus group closely related to the Flaviviridae family. Unusually, the positive-sense, single-stranded RNA genome of ALSV is segmented and consists of four distinct segments, two of which show homology with the NS3 and NS5 protein encoding regions of non-segmented flaviviruses. Transmission of arthropod-borne pathogens will likely increase in the future due to environmental change mediated by a variety of environmental and ecological factors and increasing human encroachment into wild animal habitats. In this review, we present current knowledge of global ALSV distribution and emergence patterns, highlight genetic diversity, evolution and susceptible species. Finally, we discuss the role of this emerging tick-borne virus in the context of urbanization and global health.

2024-12-11·Journal of Biomolecular Structure and Dynamics

Selected phytochemicals of Momordica charantia L. as potential anti-DENV-2 through the docking, DFT and molecular dynamic simulation

Article

作者: Ilyana Abdul Razak, Fazira ; Soliman, Mahmoud E. S. ; Roney, Miah ; Huq, A. K. M. Moyeenul ; Issahaku, Abdul Rashid ; Sapari, Suhaila ; Mohd Aluwi, Mohd Fadhlizil Fasihi ; Tajuddin, Saiful Nizam

Dengue fever is now one of the major global health concerns particularly for tropical and sub-tropical countries. However, there has been no FDA approved medication to treat dengue fever. Researchers are looking into DENV NS5 RdRp protease as a potential therapeutic target for discovering effective anti-dengue agents. The aim of this study to discover dengue virus inhibitor from a set of five compounds from Momordica charantia L. using a series of in-silico approaches. The compounds were docked into the active area of the DENV-2 NS5 RdRp protease to obtain the hit compounds. The successful compounds underwent additional testing for a study on drug-likeness similarity. Our study obtained Momordicoside-I as a lead compound which was further exposed to the Cytochrome P450 (CYP450) toxicity analysis to determine the toxicity based on docking scores and drug-likeness studies. Moreover, DFT studies were carried out to calculate the thermodynamic, molecular orbital and electrostatic potential properties for the lead compound. Moreover, the lead compound was next subjected to molecular dynamic simulation for 200 ns in order to confirm the stability of the docked complex and the binding posture discovered during docking experiment. Overall, the lead compound has demonstrated good medication like qualities, non-toxicity, and significant binding affinity towards the DENV-2 RdRp enzyme.Communicated by Ramaswamy H. Sarma.

2024-11-01·Journal of Biomolecular Structure and Dynamics

Computational evaluation of quinones of Nigella sativa L. as potential inhibitor of dengue virus NS5 methyltransferase

Article

作者: Mohd Aluwi, Mohd Fadhlizil Fasihi ; Huq, Akm Moyeenul ; Zamri, Normaiza Binti ; Tajuddin, Saiful Nizam ; Nasir, Muhammad Hassan ; Tufail, Aisha ; Dubey, Amit ; Roney, Miah

Aedes aegypti is the primary vector for the transmission of the dengue virus, which causes dengue fever, dengue hemorrhagic illness and dengue shock syndrome. There is now no antiviral medication available to treat DENV, which kills thousands of people each year and infects millions of individuals. A possible target for the creation of fresh and efficient dengue treatments is the DENV-3 NS5 MTase. So, Nigella sativa quinones were examined using in silico methods to find natural anti-DENV compounds. The in silico docking was conducted utilising the Discovery Studio software on the quinones of N. sativa and the active site of the target protein DENV-3 NS5 MTase. In addition, the druggability and pharmacokinetics of the lead compound were assessed. Dithymoquinone was comparable to the reference compound in terms of its ability to bind to the active site of target protein. Dithymoquinone met the requirements for drug likeness and Lipinski's principles, as demonstrated by the ADMET analysis and drug likeness results. The current study indicated that the dithymoquinone from N. sativa had anti-DENV activity, suggesting further drug development and dengue treatment optimisation.Communicated by Ramaswamy H. Sarma.