30S subunit

The acquisition enhances the portfolio of Aditxt in precision diagnostics and infectious disease treatment. Credit: Gorodenkoff / Shutterstock.com. Aditxt has announced a definitive agreement under which its subsidiary, Adivir, will acquire complete issued and outstanding Class A common shares of biopharmaceutical company Appili Therapeutics. The move enhances Aditxt’s portfolio and creates synergies with its existing programmes, particularly in precision diagnostics. Founded in 2015, Appili developed the Food and Drug Administration-approved LIKMEZ (ATI-1501). LIKMEZ is a reformulated version of the antibiotic metronidazole that improves patient experience and compliance by making the medication easier to swallow and better tasting. Appili licensed the manufacturing and commercialisation rights of the product in the US and other selected territories to Saptalis Pharmaceuticals. See Also: Forma Therapeutics gets grant for USP30 inhibitor compounds for medical use Dyne Therapeutics gets grant for muscle-targeting complex inhibiting DUX4 expression with oligonucleotide payload Appili is also advancing ATI-1701, a live attenuated vaccine for Francisella tularensis. The US Department of Defense has supported the ATI-1701 biodefence programme with $14m non-dilutive funding to progress the vaccine’s development. Another key asset in Appili’s portfolio is ATI-1801, a topical formulation for cutaneous leishmaniasis. The product, which contains paromomycin, offers a more patient-friendly treatment option for this painful and disfiguring disease. The acquisition will aid Aditxt in bolstering its portfolio and integrating precision diagnostics with tailored treatment strategies. The closure of the acquisition will occur in the third quarter of 2024. Aditxt co-founder, chairman and CEO Amro Albanna stated: “The acquisition of Appili would represent another step in Aditxt’s journey towards advancing promising innovations in health. “Our mission is to accelerate some of the most promising health innovations, like those developed by Appili, to reach their full potential and to have a lasting impact. “By integrating Appili’s proven expertise and diverse portfolio in the infectious disease and biodefence domain, Aditxt can substantially contribute to advancing public health solutions.”

SHANGHAI, Sept. 27, 2023 /PRNewswire/ -- Everest Medicines (HKEX 1952.HK, "Everest", or the "Company"), a biopharmaceutical company focused on the development, manufacturing and commercialization of innovative medicines and vaccines, announced today that the Taiwan Food and Drug Administration (TFDA) has approved the New Drug Application (NDA) for XERAVA® (eravacycline) for the treatment of complicated intra-abdominal infections (cIAI). "The NDA approval of XERAVA® in Taiwan marks an important step towards bringing this novel, critical therapy for complicated intra-abdominal infections and other life-threatening infections to more patients in Asia," said Rogers Yongqing Luo, Chief Executive Officer of Everest Medicines. "Following the successful commercial launch of XERAVA® in mainland China and Singapore, we will accelerate patient access to this product in more markets including Hong Kong and Taiwan." XERAVA® was approved by the National Medical Products Administration ("NMPA") of China in March 2023 and commercially launched in July. It has also been approved and commercialized in Singapore. XERAVA® has been recommended by multiple treatment guidelines in China and globally, based on its broad bacterial spectrum coverage and high potency against multidrug-resistant bacterial infections. Everest entered into an exclusive partnership agreement with TTY Biopharm (TTY) in 2022 for commercialization of XERAVA® in Taiwan. TTY is one of the largest local pharmaceutical companies in Taiwan and has led the successful commercialization of other novel anti-infective products in the region, such as Brosym (cefoperazone+sulbactam), Colistin (colimycin) and Cubicin (daptomycin). About XERAVA® (eravacycline) XERAVA® (eravacycline) is a novel, fully synthetic, broad-spectrum, fluorocycline, parenteral antibiotic of the tetracycline class that has shown broad in vitro activity against Gram-negative, Gram-positive and anaerobic pathogens that have acquired multidrug resistance (MDR) and are prevalent in China. XERAVA® is currently approved for the treatment of complicated intra-abdominal infections (cIAI) in the US, EU, UK, Singapore, mainland China, Hong Kong, and Taiwan. XERAVA® was licensed from Tetraphase Pharmaceuticals, Inc., a wholly owned subsidiary of Innoviva, Inc. About Everest Medicines Everest Medicines is a biopharmaceutical company focused on developing, manufacturing and commercializing transformative pharmaceutical products and vaccines that address critical unmet medical needs for patients in Asian markets. The management team of Everest Medicines has deep expertise and an extensive track record from both leading global pharmaceutical companies and local Chinese pharmaceutical companies in high-quality discovery, clinical development, regulatory affairs, CMC, business development and operations. Everest Medicines has built a portfolio of potentially global first-in-class or best-in-class molecules in the company's core therapeutic areas of renal diseases, infectious diseases and autoimmune disorders. For more information, please visit its website at . Forward-Looking Statements: This news release may make statements that constitute forward-looking statements, including descriptions regarding the intent, belief or current expectations of the Company or its officers with respect to the business operations and financial condition of the Company, which can be identified by terminology such as "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates," "confident" and similar statements. Such forward-looking statements are not guarantees of future performance and involve risks and uncertainties, or other factors, some of which are beyond the control of the Company and are unforeseeable. Therefore, the actual results may differ from those in the forward-looking statements as a result of various factors and assumptions, such as future changes and developments in our business, competitive environment, political, economic, legal and social conditions. The Company or any of its affiliates, directors, officers, advisors or representatives has no obligation and does not undertake to revise forward-looking statements to reflect new information, future events or circumstances after the date of this news release, except as required by law. SOURCE Everest Medicines

Everest Medicines (HKEX 1952.HK, "Everest", or the "Company"), a biopharmaceutical company focused on the development, manufacturing and commercialization of innovative medicines and vaccines, announced today that it has signed a Memorandum of Understanding ("MoU") for a strategic partnership with a subsidiary of Shanghai Pharma, SPH Keyuan Xinhua Pharmaceutical Co., Ltd. ("SPH Kyuan"). According to the MoU, Everest and SPH Kyuan will work closely to promote import and channel distribution of XERAVA (eravacycline) in China. SPH Kyuan's leading position in drug import, nationwide distribution network, and modern logistics system will help expand the scale and speed of commercialization of XERAVA to benefit patients and address urgent unmet needs in the country. XERAVA was approved by the National Medical Products Administration ("NMPA") of China for the treatment of complicated intra-abdominal infections ("cIAI") in adult patients in March 2023, and has been recommended by multiple treatment guidelines in China and globally with its broad bacterial spectrum coverage and high potency against multidrug-resistant bacterial infections. Everest plans to commercially launch XERAVA in mainland China in the third quarter of this year. "We are very excited to reach a partnership with SPH Kyuan. SPH Kyuan's rich experience in drug import and channel distribution will accelerate the delivery of XERAVA to hospitals and patients in need," said Rogers Yongqing Luo, Chief Executive Officer of Everest Medicines. "This partnership marks another step towards the successful commercialization of XERAVA, leading our pipeline with at least three more products expected to be approved in the next two years." "Everest Medicines has very promising market potential in the fields of anti-infectious and renal diseases. We are honored to reach a strategic pact with Everest around XERAVA, which will leverage the strengths of both parties," said Yu Rui, general manager of SPH Kyuan. "We look forward to continued partnership with Everest to bring more novel products to patients in need." "Drug-resistant bacteria infections is a severe problem both in China and overseas, creating both economic and healthcare burdens, and carbapenem-resistant gram-negative organisms are the focus of global attention. Due to the complex mechanism of carbapenem-resistant gram-negative organisms, it has been challenging to develop new drugs for use in clinical treatment," said Wang Hui, Deputy Director, Chief Physician at the Department of Infectious Diseases, Shanghai Jiao Tong University School of Medicine affiliated Ruijin Hospital, and Chairman-elect of Infectious Diseases Branch of Shanghai Medical Association. "Existing treatment options in China cannot meet clinical needs, and innovative drugs with broad bacterial spectrum coverage and high antibacterial potency such as XERAVA are urgently needed to cope with the challenges from drug-resistant infections". In addition to XERAVA, Everest is also actively developing other critical innovative treatment options in the infectious disease space, including taniborbactam which we plan to file for NDA in China this year for complicated urinary tract infection, and EVER206, a novel polymyxin derivative with potentially robust safety profile, which is expected to initiate phase III clinical study in the second half of this year. About XERAVA® (eravacycline) XERAVA (eravacycline) is a novel, fully synthetic, fluorocycline intravenous antibiotic for the treatment of infections caused by susceptible gram-positive , gram-negative and anaerobic pathogens including those multidrug resistant ("MDR") isolates. XERAVA is currently approved for the treatment of complicated intra-abdominal infections in the US, EU, GB, Singapore, mainland China, Hong Kong and the medicine is currently under review for cIAI in Taiwan region. XERAVA was licensed from Tetraphase Pharmaceuticals, Inc., a wholly owned subsidiary of Innoviva, Inc. About Everest Medicines Everest Medicines is a biopharmaceutical company focused on developing, manufacturing and commercializing transformative pharmaceutical products and vaccines that address critical unmet medical needs for patients in Asian markets. The management team of Everest Medicines has deep expertise and an extensive track record from both leading global pharmaceutical companies and local Chinese pharmaceutical companies in high-quality discovery, clinical development, regulatory affairs, CMC, business development and operations. Everest Medicines has built a portfolio of potentially global first-in-class or best-in-class molecules in the company's core therapeutic areas of renal diseases, infectious diseases and autoimmune disorders. For more information, please visit its website at www.everestmedicines.com. SOURCE Everest Medicines The content above comes from the network. if any infringement, please contact us to modify.